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Your search keyword '"Melanie Bloschies"' showing total 2 results
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2 results on '"Melanie Bloschies"'

1. Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype

Author

Michael Peitz, Tamara Bechler, Catrin Cornelia Thiele, Monika Veltel, Melanie Bloschies, Klaus Fliessbach, Alfredo Ramirez, and Oliver Brüstle

Subjects
Biology (General), QH301-705.5
Abstract

Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE ε4/ε4 allele.

Published
2018
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2. Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype

Author

Klaus Fliessbach, Oliver Brüstle, Catrin Cornelia Thiele, Monika Veltel, Michael Peitz, Alfredo Ramirez, Melanie Bloschies, and Tamara Bechler

Subjects
Male, 0301 basic medicine, Apolipoprotein E4, metabolism [Blood Cells], genetics [Alzheimer Disease], pathology [Alzheimer Disease], 0302 clinical medicine, neurodegenerative disease, Genotype, iPS cell line, Cellular Reprogramming Techniques, Vector (molecular biology), Induced pluripotent stem cell, lcsh:QH301-705.5, genetics [Apolipoprotein E4], Aged, 80 and over, diagnosis [Alzheimer Disease], General Medicine, genetics [Transcription Factors], Alzheimer's disease, pathology [Induced Pluripotent Stem Cells], 3. Good health, metabolism [Induced Pluripotent Stem Cells], pathology [Blood Cells], KLF4, embryonic structures, Reprogramming, metabolism [Alzheimer Disease], APOE, Induced Pluripotent Stem Cells, Biology, Polymorphism, Single Nucleotide, biosynthesis [Transcription Factors], Kruppel-Like Factor 4, 03 medical and health sciences, metabolism [Apolipoprotein E4], SOX2, Alzheimer Disease, ddc:570, Humans, SNP, Allele, Blood Cells, Cell Biology, 030104 developmental biology, lcsh:Biology (General), genotyping, Immunology, 030217 neurology & neurosurgery, Transcription Factors, Developmental Biology, dementia
Abstract

Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE ε4/ε4 allele.

Published
2018
Full Text
View/download PDF

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