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10. Federal clinical guidelines for diagnosis, treatment and prevention of osteoporosis

Author

Belaya, Zh. E., primary, Belova, K. Yu., additional, Biryukova, E. V., additional, Dedov, I. I., additional, Dzeranova, L. K., additional, Drapkina, O. M., additional, Dreval, A. V., additional, Dubovitskaya, T. A., additional, Dudinskaya, E. N., additional, Ershova, O. B., additional, Zagorodniy, N. V., additional, Ilyukhina, O. B., additional, Kanis, J. A., additional, Kryukova, I. V., additional, Lesnyak, O. M., additional, Mamedova, E. O., additional, Marchenkova, L. A., additional, Mel’nichenko, G. A., additional, Nikankina, L. V., additional, Nikitinskaya, O. A., additional, Petryaikin, A. V., additional, Pigarova, E. A., additional, Rodionova, S. S., additional, Rozhinskaya, L. Ya., additional, Skripnikova, I. A., additional, Tarbaeva, N. V., additional, Tkacheva, O. N., additional, Toroptsova, N. V., additional, Farba, L. Ya., additional, Tsoriev, T. T., additional, Chernova, T. O., additional, Yureneva, S. V., additional, and Yakushevskaya, O. V., additional

Published
2021
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16. Glucose metabolism and incretins level in morbidly obese patients and in patients after biliopancreatic diversion performed for morbid obesity

Author

Mel'nichenko G A, Dedov I I, Mazurina N, Yashkov Yu I, A V Il'in, Troshina E A, and Ogneva N A

Subjects
gip, medicine.medical_specialty, obesity, Physiology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, QD415-436, Hypoglycemia, Glucagon, Biochemistry, Impaired glucose tolerance, Endocrinology, Insulin resistance, Internal medicine, Diabetes mellitus, biliopancreatic diversion, Internal Medicine, medicine, QP1-981, Nutrition and Dietetics, business.industry, Insulin, Public Health, Environmental and Occupational Health, glp-1, medicine.disease, Impaired fasting glucose, Postprandial, hypoglycemia, glucagon, business, hormones, hormone substitutes, and hormone antagonists
Abstract

We’ve studied a carbohydrate metabolism in morbidly obese (MO) patients and the patients after bariatric surgery. The patients of the 1st group had BMI40 (n=22) and no history of diabetes mellitus. Patients after biliopancreatic diversion (BPD) performed for MO were included in the 2nd group (n=23). The 3rd group was a control group of normal weight healthy subjects (n=22). Blood glucose levels, insulin, GLP-1, GIP and glucagon during the OGTT (with 75 g of glucose) at 0, 30, 60 and 120 minutes were measured in all patients. In MO group fasting glucose levels were the highest. Impaired glucose metabolism was revealed in 68.2% of patients (n=10). Impaired fasting glucose (IFG) was diagnosed in 4 cases (18.2%), impaired glucose tolerance (IGT) in 11 patients (50%). In the BPD postprandial blood glucose levels (120 min) were lower if compared to the other groups. In 4 individuals (17.4%) we found postprandial hypoglycemia (2.8 mmol/l). Patients of the MO group had the highest fasting insulin levels and HOMA-IR (p0.001). The maximum of insulin concentration was seen on minute 30 of the OGTT in the 2nd and 3rd groups, and it was significantly higher in the post-bariatric patients (p=0.026). In MO group the maximum of the plasma insulin levels were on the 60th minute and were still elevated after 120 minutes. Fasting and stimulated (on the 30th minute) levels of GLP-1 were significantly higher after BPD (р=0.037 and p=0.022 at 0 and 30 min, respectively). Morbidly obese patients had higher fasting and stimulated GIP. Fasting glucagon concentrations were similar in the surgical and control groups, while the people with MO had higher initial levels of glucagon (p=0.013) and it was not suppressed during the OGTT (p=0.076). Glucose intolerance and insulin resistance incidence was higher in MO patients. Hyperglucagonemia, increased GIP and decreased GLP-1 levels are observed in MO patients. Stimulated plasma insulin and GLP-1 concentrations were significantly increased in patients who underwent BPD, and may cause postprandial hypoglycemia.

Published
2014

19. Metabolic complications of endogenous Cushing: patient selection for screening

Author

Dzeranova L K, Dragunova N, Marova E I, Rozhinskaya L Y, Molitvoslovova N N, Dedov I I, Mel'nichenko G A, Belaya Zh E, Arapova S D, and Zenkova T S

Subjects
endocrine system, medicine.medical_specialty, Physiology, Endocrinology, Diabetes and Metabolism, Population, QD415-436, cortisol, Biochemistry, Gastroenterology, Endocrinology, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, QP1-981, Adrenal adenoma, complications of hypercortisolism, education, acth, education.field_of_study, Nutrition and Dietetics, business.industry, cushing's disease, Public Health, Environmental and Occupational Health, Muscle weakness, Cushing's disease, medicine.disease, endogenous hypercortisolism, Amenorrhea, medicine.symptom, Metabolic syndrome, business, Weight gain, hormones, hormone substitutes, and hormone antagonists
Abstract

Aims: this study evaluates the most common associations of symptoms and complications in patients with Cushing’s syndrome (CS) in order to choose a potential population to be screened for CS and estimates the diagnostic accuracy of first line screening tests (cortisol, ACTH) to differentiate ACTH-ectopic CS from Cushing’s disease. Materials and Methods: The clinical data of 259 patients with proven CS during 2001–2011 was analyzed. The clinical presentations of 197 patients (159 Cushing’s disease, 28 ACTH-ectopic CS and 10 cases of benign cortisol-secreting adrenal adenoma) were compared according to the cause of hypercortisolism. ROC-analysis was performed to estimate the diagnostic accuracy of the first line tests (cortisol, ACTH) to suggest ACTH-ectopic CS. A threshold for the test with the highest area under the curves was chosen based on the maximum sum of the sensitivity and specificity. Results: The most frequent complaints were related to fatigue, muscle weakness, weight gain and changes in appearance (facial plethora and fullness, striae). Among the complications of CS the most frequent were being overweight or obese (71%), hypertension (63%), dislipoproteinemia (41%), low traumatic fractures (43%) and steroid-induced diabetes (31%). In women, 16% were older than 50, in those who were younger amenorrhea was registered in 43%. The patients with ACTH-ectopic CS had higher rate of low traumatic fractures (p=0.04), increased serum late-night cortisol, 24 hours urinary free cortisol, morning and evening ACTH and lower levels of potassium (p0.01 for all parameters). Plasma late-night ACTH measurements showed the highest AUC (0,811 (95% CI 0,712–0,909)) to differentiate ACTH-ectopic CS from Cushing’s disease. A cut off value of 108.9 pg/ml for late-night ACTH yielded a sensitivity of 60,7% and a specificity of 79%. Conclusions: patients with a coexistence of obesity, muscle weakness, fatigue, some components of metabolic syndrome and especially low traumatic fractures should be screened for CS. High plasma late night ACTH values in patients with proven CS value suggest ACTH-ectopic syndrome.

Published
2013

23. Ozhirenie u podrostkov v Rossii

Author

Taranushenko T E, Chebotnikova T, Chernyak I Yu, Zaykova I O, Mel'nichenko G A, Smetanina S A, Mikhaylova E G, Vorob'eva V A, Dedov I I, Buydina T A, Suplotova L A, Panfilova V N, Yanovskaya M E, Shalennaya I G, Kovarenko M A, Oorzhak U S, Sergeeva N E, Kiseleva N G, Vikhareva M, Savel'eva L, Esayan R M, Butrova S A, P'yankova E Yu, Bodaveli O, Kamshilova K A, and Kharitonova N E

Subjects
Nutrition and Dietetics, Endocrinology, business.industry, Physiology, Endocrinology, Diabetes and Metabolism, Public Health, Environmental and Occupational Health, Internal Medicine, Medicine, QP1-981, QD415-436, business, Biochemistry
Abstract

Исследование выполнено при поддержке фармацевтической компании «Ф. Хоффман-Ля Рош Лтд».

Published
2006

24. Zhirovaya tkan' kak endokrinnyy organ

Author

Dedov I I, Mel'nichenko G A, and Butrova S A

Subjects
Nutrition and Dietetics, Endocrinology, Physiology, business.industry, Endocrinology, Diabetes and Metabolism, Public Health, Environmental and Occupational Health, Internal Medicine, QP1-981, Medicine, QD415-436, business, Biochemistry
Published
2006

26. Statiny v lechenii dislipidemii pri sakharnom diabete 2 tipa

Author

Irina Vladimirovna Glinkina and Mel'nichenko G A

Subjects
Nutrition and Dietetics, Endocrinology, Physiology, Endocrinology, Diabetes and Metabolism, Public Health, Environmental and Occupational Health, Internal Medicine, QP1-981, QD415-436, Biochemistry
Published
2005

40. The role of prolactin gradient and normalized ACTH/prolactin ratio in the improvement of sensitivity and specificity of selective blood sampling from inferior petrosal sinuses for differential diagnostics of ACTH-dependent hypercorticism

Author

Belaia, Zh E, primary, Rozhinskaia, L Ia, additional, Mel'nichenko, G A, additional, Sitkin, I I, additional, Dzeranova, L K, additional, Marova, E I, additional, Vaks, V V, additional, Vorontsov, A V, additional, Il'in, A V, additional, Kolesnikova, G S, additional, and Dedov, I I, additional

Published
2013
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42. Medullary Thyroid Cancer: Management Guidelines

Author

Abdulkhabirova, F M, primary, Bel'tsevich, D G, additional, Vanushko, V E, additional, Dedov, I I, additional, Kuznetsov, N S, additional, Mel'nichenko, G A, additional, Platonova, N M, additional, Rumyantsev, P O, additional, Troshina, E A, additional, Tyul'pakov, A N, additional, Fadeev, V V, additional, Kropotov, M A, additional, Lyubchenko, L N, additional, Mudunov, A M, additional, Podvyaznikov, S O, additional, Polyakov, V G, additional, Romanov, I S, additional, Subramanian, S, additional, Tyulyandin, S A, additional, Brzhezovskiy, V Zh, additional, Abrosimov, A Yu, additional, Il'in, A A, additional, Isaev, P A, additional, Medvedev, V S, additional, Rumyantseva, U V, additional, Ol'shanskiy, V O, additional, Reshetov, I V, additional, Makhson, A N, additional, Bondarenko, V O, additional, Vetshev, P S, additional, Zaletaev, D V, additional, Ivanov, Yu V, additional, Kozhanov, L G, additional, Soldatov, I V, additional, Kharnas, S S, additional, Barchuk, A S, additional, Bershteyn, L M, additional, Sleptsov, I V, additional, Chernikov, R A, additional, Bubnov, A N, additional, Grineva, E N, additional, Manikhas, G M, additional, Romanchishen, A F, additional, Korenev, S V, additional, Vikhlyanov, I V, additional, Gashchenko, A D, additional, Dvornichenko, V V, additional, Kiyaev, A V, additional, Privalov, V A, additional, Yaytsev, S V, additional, Svetitskiy, P V, additional, Khasanov, R Sh, additional, Tsvetaev, V A, additional, Choynzonov, E L, additional, and Shevchenko, S P, additional

Published
2013
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47. Medullary Thyroid Cancer: Management Guidelines

Author

Abdulkhabirova, F M, primary, Bel'tsevich, D G, additional, Vanushko, V E, additional, Dedov, I I, additional, Kuznetsov, N S, additional, Mel'nichenko, G A, additional, Platonova, N M, additional, Rumyantsev, P O, additional, Troshina, E A, additional, Tyul'pakov, A N, additional, Fadeev, V V, additional, Abrosimov, A Yu, additional, Il'in, A A, additional, Isaev, P A, additional, Medvedev, V S, additional, Rumyantseva, U V, additional, Brzhezovskiy, V Zh, additional, Kropotov, M A, additional, Lyubchenko, L N, additional, Podvyaznikov, S O, additional, Polyakov, V G, additional, Romanov, I S, additional, Subramanian, S, additional, Tyulyandin, S A, additional, Ol'shanskiy, V O, additional, Reshetov, I V, additional, Makhson, A N, additional, Bondarenko, V O, additional, Vetshev, P S, additional, Glezerov, E A, additional, Zaletaev, D V, additional, Ivanov, Yu V, additional, Kozhanov, L G, additional, Soldatov, I V, additional, Kharnas, S S, additional, Barchuk, A S, additional, Bershteyn, L M, additional, Bubnov, A N, additional, Sleptsov, I V, additional, Chernikov, R A, additional, Grineva, E N, additional, Manikhas, G M, additional, Romanchishen, A F, additional, Korenev, S V, additional, Vikhlyanov, I V, additional, Gashchenko, A D, additional, Dvornichenko, V V, additional, Kiyaev, A V, additional, Privalov, V A, additional, Yaytsev, S V, additional, Svetitskiy, P V, additional, Khasanov, R Sh, additional, Tsvetaev, V A, additional, Choynzonov, E L, additional, and Shevchenko, S P, additional

Published
2012
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