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Introduction: Recombinant human erythropoietin (rHuEpo) administration enhances oxygen carrying capacity and performance at sea level. It remains unknown whether similar effects would be observed in chronic altitude-adapted endurance runners. The aim of this study was to assess the effects of rHuEpo on hematological and performance parameters in chronic altitude-adapted endurance runners as compared to sea level athletes. Methods: Twenty well-trained Kenyan endurance runners (KEN) living and training at approximately 2150 m received rHuEpo injections of 50 IU·kg−1 body mass every 2 d for 4 wk and responses compared with another cohort (SCO) that underwent an identical protocol at sea level. Blood samples were obtained at baseline, during rHuEpo administration and 4 wk after the final injection. A maximal oxygen uptake (V˙O2max) test and 3000-m time trial was performed before, immediately after and 4 wk after the final rHuEpo injection. Results: Hematocrit (HCT) and hemoglobin concentration (HGB) were higher in KEN compared to SCO before rHuEpo but similar at the end of administration. Before rHuEpo administration, KEN had higher V˙O2max and faster time trial performance compared to SCO. After rHuEpo administration, there was a similar increase in V˙O2max and time trial performance in both cohorts; most effects of rHuEpo were maintained 4 wk after the final rHuEpo injection in both cohorts. Conclusions: Four weeks of rHuEpo increased the HGB and HCT of Kenyan endurance runners to a lesser extent than in SCO (~17% vs ~10%, respectively) and these alterations were associated with similar improvements in running performance immediately after the rHuEpo administration (~5%) and 4 wk after rHuEpo (~3%). [ABSTRACT FROM AUTHOR]

Introduction: Fasting, the voluntary abstention from all restricted foods, is a feature of many religions, and the putative health benefits have attracted both scientific and popular interest. There is no clear understanding that religious fasting has great effects on metabolic syndrome. There is little data available that provides information concerning Ethiopian Orthodox Christians fasting influence on metabolic syndrome indices and serum electrolytes to date. To determine the effect of 'Abiy tsom' (lent fasting) of Ethiopian Orthodox Christians on metabolic syndrome indices and serum electrolytes in Addis Ababa, Ethiopia. Methods: 88 Study subjects were included conveniently who were followers of Ethiopian Orthodox Christianity faith and fasting "lent" and longitudinal cross-sectional study design was employed. Data were collected twice, the first during last week of the fasting months and the second during the last week of two months' time after returning to usual diet. The data and sample were collected, analyzed, interpreted and was displayed by using descriptive and analytical statistical methods. Results: Our study found that Ethiopian Orthodox lent fasting had clear and significant effects on Anthropometric measurements, systolic blood pressure, lipid profiles, and Urea. It was also found that this fasting decreased the levels of Calcium and Chloride ions while Serum sodium and potassium were influenced insignificantly. Conclusion: Ethiopian Orthodox Christians lent fasting is beneficial for weight loss and fighting metabolic syndrome. [ABSTRACT FROM AUTHOR]