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3. Spectrum of severity of multisystem inflammatory syndrome in children: an EHR-based cohort study from the RECOVER program

Author

Rao, Suchitra, Jing, Naimin, Liu, Xiaokang, Lorman, Vitaly, Maltenfort, Mitchell, Schuchard, Julia, Wu, Qiong, Tong, Jiayi, Razzaghi, Hanieh, Mejias, Asuncion, Lee, Grace M., Pajor, Nathan M., Schulert, Grant S., Thacker, Deepika, Jhaveri, Ravi, Christakis, Dimitri A., Bailey, L. Charles, Forrest, Christopher B., and Chen, Yong

Published
2023
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4. Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data

Author

Arruda, Eurico, Baillie, Vicky L, Chong, Debora, Crow, Rowena, Filho, Nelson Rosário, Laubscher, Marius, Madhi, Shabir A, Mrcela, Dina, Ramilo, Octavio, Roje, Damir, Stein, Renato Tetelbom, Yung, Chee Fu, Wang, Xin, Li, You, Shi, Ting, Bont, Louis J, Chu, Helen Y, Zar, Heather J, Wahi-Singh, Bhanu, Ma, Yiming, Cong, Bingbing, Sharland, Emma, Riley, Richard D, Deng, Jikui, Figueras-Aloy, Josep, Heikkinen, Terho, Jones, Marcus H, Liese, Johannes G, Markić, Joško, Mejias, Asuncion, Nunes, Marta C, Resch, Bernhard, Satav, Ashish, Yeo, Kee Thai, Simões, Eric A F, and Nair, Harish

Published
2024
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6. Differences in SARS-CoV-2 Clinical Manifestations and Disease Severity in Children and Adolescents by Infecting Variant

Author

Quintero, Ana Maria, Eisner, Mariah, Sayegh, Rouba, Wright, Tori, Ramilo, Octavio, Leber, Amy L., Wang, Huanyu, and Mejias, Asuncion

Subjects
Child health services -- Usage, Children -- Diseases, Hospital patients -- Care and treatment, Health
Abstract

SARS-CoV-2, the etiologic agent of COVID-19, rapidly spread worldwide, causing a global pandemic with major social and economic disruption. Although the effects of COVID-19 have been greater in adults, children [...]

Published
2022
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9. Contributors

Author

Abzug, Mark J., primary, Adderson, Elisabeth E., additional, Agarwal, Aastha, additional, Agwu, Allison L., additional, Albenberg, Lindsey, additional, Albert, Jonathan, additional, Alby, Kevin, additional, Aldrovandi, Grace M., additional, Allen, Upton D., additional, Alvarez-Hernndez, Gerardo, additional, Ampofo, Krow, additional, Anderson, Evan J., additional, Appiah, Grace D., additional, Ardura, Monica I., additional, Arnon, Stephen S., additional, Aronson, Naomi E., additional, Arvin, Ann M., additional, Ashkenazi, Shai, additional, Ashkenazi-Hoffnung, Liat, additional, Asturias, Edwin J., additional, Aukstuolis, Kestutis, additional, Badalyan, Vahe, additional, Baker, Carol J., additional, Balakrishnan, Karthik, additional, Barnett, Elizabeth D., additional, Bechtel, Kirsten, additional, Benitz, William E., additional, Berkovich, Rachel, additional, Berman, David M., additional, Bialek, Stephanie R., additional, Bijker, Else M., additional, Bizzarro, Matthew J., additional, Bloch, Karen C., additional, Bocchini, Joseph A., additional, Boyce, Thomas G., additional, Bradley, John S., additional, Bratcher, Denise F., additional, Braverman, Paula K., additional, Brook, Itzhak, additional, Brown, Kevin Edward, additional, Bryant, Kristina P., additional, Camacho-Gonzalez, Andres F., additional, Caete-Gibas, Connie F., additional, Cantey, Joseph B., additional, Cantey, Paul, additional, Cardemil, Cristina V., additional, Caserta, Mary T., additional, Castagnini, Luis A., additional, Cataldi, Jessica R., additional, Chadwick, Ellen Gould, additional, Chancey, Rebecca J., additional, Cherry, Cara C., additional, Chiang, Silvia S., additional, Choi, Mary, additional, Christenson, John C., additional, Coffin, Susan E., additional, Cohn, Amanda, additional, Contopoulos-Ioannidis, Despina G., additional, Conway, James H., additional, Cortese, Margaret M., additional, Creech, C. Buddy, additional, Crews, Jonathan D., additional, Curtis, Donna, additional, Curtis, Nigel, additional, Danziger-Isakov, Lara A., additional, Darville, Toni, additional, Dasch, Gregory A., additional, Daskalaki, Irini, additional, Davies, H. Dele, additional, Dawood, Fatimah S., additional, Day, J. Christopher, additional, Teresa de la Morena, M., additional, DeMuri, Gregory P., additional, Despommier, Dickson D., additional, Dodson, Daniel S., additional, Dolgner, Stephen J., additional, Dunn, Clinton, additional, Dyal, Jonathan, additional, Edwards, Kathryn M., additional, Edwards, Morven S., additional, Eichenfield, Dawn Z., additional, Eichenfield, Lawrence F., additional, Elston, Dirk M., additional, Emerson, Beth, additional, Enane, Leslie A., additional, Ephros, Moshe, additional, Erdem, Guliz, additional, Eremeeva, Marina E., additional, Esposito, Douglas H., additional, Farley, Monica M., additional, Feingold, Anat R., additional, Feja, Kristina N., additional, Finn, Adam, additional, Fischer, Marc, additional, Fisher, Brian T., additional, Fisher, Randall G., additional, Flynn, Patricia Michele, additional, Foster, Monique A., additional, Fox, LeAnne M., additional, Frank, Michael M., additional, Fredrick, Douglas R., additional, Frenck, Robert W., additional, Gaensbauer, James, additional, Gans, Hayley A., additional, Gauthier, Gregory M., additional, Gavigan, Patrick, additional, Gerber, Jeffrey S., additional, Gernez, Yael, additional, Gigliotti, Francis, additional, Gilger, Mark A., additional, Glaser, Carol A., additional, Gould, Jane M., additional, Graziano, James, additional, Green, Amanda M., additional, Green, Michael, additional, Griffin, Daniel, additional, Griffin, Patricia M., additional, Griffith, David C., additional, Gupta, Piyush, additional, Gutelius, Bruce J., additional, Gutman, Julie R., additional, Hall, Aron J., additional, Hamdy, Rana F., additional, Han, Jin-Young, additional, Handy, Lori K., additional, Hanisch, Benjamin, additional, Harper, Marvin B., additional, Harris, Aaron M., additional, Harrison, Christopher J., additional, Haslam, David B., additional, Haston, Julia C., additional, Hawkes, Sarah.J., additional, Heald-Sargent, Taylor, additional, Hendley, J. Owen, additional, Hersh, Adam L., additional, Hilinski, Joseph A., additional, Hills, Susan L., additional, Hong, David K., additional, Hotez, Peter J., additional, Hsu, Katherine K., additional, Huang, Felicia Scaggs, additional, Hunstad, David A., additional, Hunt, W. Garrett, additional, Hwang, Loris Y., additional, Ilboudo, Christelle M., additional, Jaggi, Preeti, additional, Jean, Sophonie, additional, Jhaveri, Ravi, additional, Jirk-Pomajbkov, Kateina, additional, Kadry, Nadia A., additional, Kamb, Mary L., additional, Kapadia, Ronak K., additional, Katz, Ben Z., additional, Katz, Sophie E., additional, Kaur, Ishminder, additional, Kersh, Gilbert J., additional, Khan, Muhammad Ali, additional, Khurana, Ananta, additional, Kimberlin, David W., additional, Klein, Bruce, additional, Kobayashi, Miwako, additional, Kociolek, Larry K., additional, Koh, Andrew Y., additional, Kotloff, Karen L., additional, Kroger, Andrew T., additional, Kronman, Matthew P., additional, Lalor, Leah, additional, Lauren, Christine T., additional, Leber, Amy, additional, Leshem, Eyal, additional, Lewis, David B., additional, Livingston, Robyn A., additional, Llata, Eloisa, additional, Lloyd, Kevin, additional, Loh, Katrina, additional, Long, Sarah S., additional, Lopman, Benjamin A., additional, Lucero, Yalda C., additional, Lugo, Debra J., additional, Lujn-Zilbermann, Jorge, additional, Maldonado, Yvonne A., additional, Manaloor, John J., additional, Manthiram, Kalpana, additional, Martin, Stacey W., additional, Mathew, Roshni, additional, Mazzulli, Tony, additional, McFarland, Elizabeth J., additional, McGann, Kathleen A., additional, McNamara, Lucy A., additional, Meislich, Debrah, additional, Meissner, H. Cody, additional, Mejias, Asuncion, additional, Mertsola, Jussi, additional, Messacar, Kevin, additional, Mhaissen, Mohammad Nael, additional, Michaels, Marian G., additional, Miller, Melissa B., additional, Miller-Handley, Hilary, additional, Mintz, Eric, additional, Mohan, Parvathi, additional, Montgomery, Susan P., additional, Montoya, Jose G., additional, Moorman, Anne C., additional, Moro, Pedro L., additional, Moscicki, Anna-Barbara, additional, Muller, William J., additional, Myers, Angela L., additional, Nadel, Simon, additional, Nayak, Jennifer Lynn, additional, Neely, Michael Noel, additional, Neil, Karen P., additional, Nelson, Christina A., additional, Nelson, Noele P., additional, Nichols, Megin, additional, Nicholson, William, additional, Nopper, Amy Jo, additional, Norton, Laura E., additional, Ochoa, Theresa J., additional, Olarte, Liset, additional, Onarecker, Timothy R., additional, Orenstein, Walter A., additional, ORyan, Miguel, additional, Otto, William R., additional, Ouellette, Christopher P., additional, Paddock, Christopher D., additional, Palazzi, Debra L., additional, Panuganti, Suresh Kumar, additional, Pappas, Diane E., additional, Paret, Michal, additional, Pastula, Daniel M., additional, Patterson, Thomas F., additional, Petersen, Brett W., additional, Petrosyan, Mikael, additional, Pickering, Larry K., additional, Pindyck, Talia, additional, Pinninti, Swetha, additional, Pittet, Laure F., additional, Planet, Paul J., additional, Pollard, Andrew J., additional, Posfay-Barbe, Klara M., additional, Poulsen, Casper S., additional, Poutanen, Susan M., additional, Powers, Ann M., additional, Prasanphanich, Nina Salinger, additional, Pritt, Bobbi S., additional, Prober, Charles G., additional, Puar, Neha, additional, Quilter, Laura A.S., additional, Ramilo, Octavio, additional, Rao, Suchitra, additional, Ratner, Adam J., additional, Rawstron, Sarah A., additional, Read, Jennifer S., additional, Relich, Ryan F., additional, Reller, Megan E., additional, Robinson, Candice L., additional, Romero, Jos R., additional, Rosen, David A., additional, Ross, Shannon A., additional, Rours, G. Ingrid J.G., additional, Rowe, Peter C., additional, Rowley, Anne H., additional, Rubin, Lorry G., additional, Ryan, Edward T., additional, Sacharok, Alexandra, additional, Sandora, Thomas J., additional, Sapp, Sarah G.H., additional, Sardana, Kabir, additional, Sauberan, Jason B., additional, Schaffzin, Joshua K., additional, Schillie, Sarah, additional, Schuster, Jennifer E., additional, Schwartz, Kevin L., additional, Sederdahl, Bethany K., additional, Serpa-Alvarez, Jose, additional, Shah, Kara N., additional, Shah, Samir S., additional, Shaikh, Nader, additional, Shane, Andi L., additional, Shapiro, Eugene D., additional, Shaw, Jana, additional, Shetty, Avinash K., additional, Shope, Timothy R., additional, Dairiki Shortliffe, Linda M., additional, Shulman, Stanford T., additional, Shust, Gail F., additional, Siberry, George Kelly, additional, Siegel, Jane D., additional, Siegel, Robert David, additional, Simonsen, Kari A., additional, Singh, Upinder, additional, Smith, Christiana, additional, Smith, Lauren L., additional, Song, Eunkyung, additional, Souder, Emily, additional, Spearman, Paul, additional, St. Geme, Joseph W., additional, Staat, Mary Allen, additional, Staples, J. Erin, additional, Starke, Jeffrey R., additional, Statler, Victoria A., additional, Steinbach, William J., additional, Stensvold, Christen Rune, additional, Stokes, Erin K., additional, Stoner, Bradley P., additional, Storch, Gregory A., additional, Straily, Anne, additional, Sullivan, Kathleen E., additional, Swanson, Douglas S., additional, Tanz, Robert R., additional, Taormina, Gillian, additional, Tate, Jacqueline E., additional, Taveras, Jeanette, additional, Tebruegge, Marc, additional, Teshale, Eyasu H., additional, Thompson, George R., additional, Thompson-Stone, Robert, additional, Thomsen, Isaac, additional, Thomson, Richard B., additional, Thorell, Emily A., additional, Tien, Vivian, additional, Tobin, Nicole H., additional, Toltzis, Philip, additional, Treat, James, additional, Troy, Stephanie B., additional, Van Dvke, Russell B., additional, Vaz, Louise Elaine, additional, Vijayan, Vini, additional, Vodzak, Jennifer, additional, Wagner, Thor A., additional, Wald, Ellen R., additional, Wallihan, Rebecca, additional, Wang, Huanyu, additional, Wangu, Zoon, additional, Washam, Matthew, additional, Waters, Valerie, additional, Watson, Joshua R., additional, Weatherhead, Jill E., additional, Weinberg, Geoffrey A., additional, Weng, Mark K., additional, Wiederhold, Nathan P., additional, Wiesenfeld, Harold C., additional, Williams, Cydni, additional, Williams, John V., additional, Willoughby, Rodney E., additional, Wittler, Robert R., additional, Wood, James B., additional, Woods, Charles Reece, additional, Workowski, Kimberly A., additional, Wright, Terry W., additional, Wu, Hsi-Yang, additional, Xu, Huan, additional, Yagupsky, Pablo, additional, Yi, Jumi, additional, Yoder, Jonathan, additional, Young, Edward J., additional, Zaenglein, Andrea L., additional, Zimmermann, Petra, additional, and Zong, Wenjing, additional

Published
2023
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11. Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape

Author

Mazur, Natalie I, Terstappen, Jonne, Baral, Ranju, Bardají, Azucena, Beutels, Philippe, Buchholz, Ursula J, Cohen, Cheryl, Crowe, James E, Jr, Cutland, Clare L, Eckert, Linda, Feikin, Daniel, Fitzpatrick, Tiffany, Fong, Youyi, Graham, Barney S, Heikkinen, Terho, Higgins, Deborah, Hirve, Siddhivinayak, Klugman, Keith P, Kragten-Tabatabaie, Leyla, Lemey, Philippe, Libster, Romina, Löwensteyn, Yvette, Mejias, Asuncion, Munoz, Flor M, Munywoki, Patrick K, Mwananyanda, Lawrence, Nair, Harish, Nunes, Marta C, Ramilo, Octavio, Richmond, Peter, Ruckwardt, Tracy J, Sande, Charles, Srikantiah, Padmini, Thacker, Naveen, Waldstein, Kody A, Weinberger, Dan, Wildenbeest, Joanne, Wiseman, Dexter, Zar, Heather J, Zambon, Maria, and Bont, Louis

Published
2023
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13. EHR-based Case Identification of Pediatric Long COVID: A Report from the RECOVER EHR Cohort

Author

Botdorf, Morgan, primary, Dickinson, Kimberley, additional, Lorman, Vitaly, additional, Razzaghi, Hanieh, additional, Marchesani, Nicole, additional, Rao, Suchitra, additional, Rogerson, Colin, additional, Higginbotham, Miranda, additional, Mejias, Asuncion, additional, Salyakina, Daria, additional, Thacker, Deepika, additional, Dandachi, Dima, additional, Christakis, Dimitri A, additional, Taylor, Emily, additional, Schwenk, Hayden, additional, Morizono, Hiroki, additional, Cogen, Jonathan, additional, Pajor, Nate M, additional, Jhaveri, Ravi, additional, Forrest, Christopher B., additional, and Bailey, L. Charles, additional

Published
2024
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14. A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike

Author

Lu, Mijia, Dravid, Piyush, Zhang, Yuexiu, Trivedi, Sheetal, Li, Anzhong, Harder, Olivia, KC, Mahesh, Chaiwatpongsakorn, Supranee, Zani, Ashley, Kenney, Adam, Zeng, Cong, Cai, Chuanxi, Ye, Chengjin, Liang, Xueya, Shimamura, Masako, Liu, Shan-Lu, Mejias, Asuncion, Ramilo, Octavio, Boyaka, Prosper N., Qiu, Jianming, Martinez-Sobrido, Luis, Yount, Jacob S., Peeples, Mark E., Kapoor, Amit, Niewiesk, Stefan, and Li, Jianrong

Published
2021

15. The interdependence between rhinovirus cycle threshold values, viral co‐detections, and clinical disease severity in children with and without comorbidities.

Author

Sánchez Códez, María Isabel, Benavente Fernández, Isabel, Moyer, Katherine, Leber, Amy L., Ramilo, Octavio, and Mejias, Asuncion

Abstract

Rhinoviruses (RVs) are a leading cause of acute respiratory infections (ARI) in children. The relationship between RV viral loads (VL), RV/viral‐co‐detections and disease severity, is incompletely understood. We studied children and adolescents ≤21 years with RV‐ARI that were identified as inpatients or outpatients using a PCR panel from 2011‐2013. RV VL were stratified according to cycle threshold (CT) values in high (≤25), intermediate (26‐32) and low (>32). Adjusted analyses were performed to assess the role RV VL and RV/viral codetections on hospital admission, oxygen requirement, PICU care, and length of stay. Of 1,899 children with RV‐ARI, 78% had chronic comorbidities and 24% RV/viral co‐detections. Single RV vs RV/viral co‐detections was associated with higher VL (24.74 vs 26.62 CT; p = 0.001) and older age (14.9 vs 9.5 months; p = 0.0001). Frequency of RV/viral co‐detections were inversely proportional to RV loads: 32% with low; 28% with intermediate, and 19% with high VL, p = 0.0001. Underlying conditions were independently associated with all clinical outcomes, high VL with PICU care, and single RV‐ARI with higher odds of hospitalization. In summary, single RV vs RV/viral co‐detections were associated with higher VL and older age. Underlying diseases, rather than RV loads or RV/viral co‐detections, consistently predicted worse clinical outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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16. RSV Prevention Within Reach for Older Infants and Toddlers: The Role of Active Immunization.

Author

Mejias, Asuncion and Ramilo, Octavio

Subjects
*PREVENTION of infectious disease transmission, *THERAPEUTIC use of monoclonal antibodies, *IMMUNIZATION, *VACCINE development, *RESPIRATORY syncytial virus, *INTRANASAL administration, *RESPIRATORY syncytial virus infections, *VIRAL vaccines, *RECOMBINANT proteins, *VACCINE immunogenicity, *COVID-19 pandemic, *CHILDREN
Abstract

This review article will summarize the vaccines and monoclonal antibodies currently under evaluation for the prevention of RSV disease in older infants, toddlers and young children. We will review the rationale for passive protection during the first months of life, and the role of active immunization afterwards, either with live attenuated, protein-based or mRNA vaccines. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Whole blood transcriptional profiles as a prognostic tool in complete and incomplete Kawasaki Disease

Author

Jaggi, Preeti, Mejias, Asuncion, Xu, Zhaohui, Yin, Han, Moore-Clingenpeel, Melissa, Smith, Bennett, Burns, Jane C, Tremoulet, Adriana H, Jordan-Villegas, Alejandro, Chaussabel, Damien, Texter, Karen, Pascual, Virginia, and Ramilo, Octavio

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Genetics, Pediatric, Prevention, Adenoviridae, Child, Child, Preschool, Female, Gene Expression Profiling, Humans, Longitudinal Studies, Male, Mucocutaneous Lymph Node Syndrome, Prognosis, Retrospective Studies, General Science & Technology
Abstract

BackgroundEarly identification of children with Kawasaki Disease (KD) is key for timely initiation of intravenous immunoglobulin (IVIG) therapy. However, the diagnosis of the disease remains challenging, especially in children with an incomplete presentation (inKD). Moreover, we currently lack objective tools for identification of non-response (NR) to IVIG.MethodsChildren with KD were enrolled and samples obtained before IVIG treatment and sequentially at 24 h and 4-6 weeks post-IVIG in a subset of patients. We also enrolled children with other febrile illnesses [adenovirus (AdV); group A streptococcus (GAS)] and healthy controls (HC) for comparative analyses. Blood transcriptional profiles were analyzed to define: a) the cKD and inKD biosignature, b) compare the KD signature with other febrile illnesses and, c) identify biomarkers predictive of clinical outcomes.ResultsWe identified a cKD biosignature (n = 39; HC, n = 16) that was validated in two additional cohorts of children with cKD (n = 37; HC, n = 20) and inKD (n = 13; HC, n = 8) and was characterized by overexpression of inflammation, platelets, apoptosis and neutrophil genes, and underexpression of T and NK cell genes. Classifier genes discriminated KD from adenovirus with higher sensitivity and specificity (92% and 100%, respectively) than for GAS (75% and 87%, respectively). We identified a genomic score (MDTH) that was higher at baseline in IVIG-NR [median 12,290 vs. 5,572 in responders, p = 0.009] and independently predicted IVIG-NR.ConclusionA reproducible biosignature from KD patients was identified, and was similar in children with cKD and inKD. A genomic score allowed early identification of children at higher risk for non-response to IVIG.

Published
2018

20. Whole-Blood Gene Expression Profile After Hypoxic-Ischemic Encephalopathy

Author

Montaldo, Paolo, primary, Burgod, Constance, additional, Herberg, Jethro A., additional, Kaforou, Myrsini, additional, Cunnington, Aubrey J., additional, Mejias, Asuncion, additional, Cirillo, Grazia, additional, Miraglia Del Giudice, Emanuele, additional, Capristo, Carlo, additional, Bandiya, Prathik, additional, Kamalaratnam, Chinnathambi N., additional, Chandramohan, Rema, additional, Manerkar, Swati, additional, Rodrigo, Ranmali, additional, Sumanasena, Samanmali, additional, Krishnan, Vaisakh, additional, Pant, Stuti, additional, Shankaran, Seetha, additional, and Thayyil, Sudhin, additional

Published
2024
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22. Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data

Author

Wang, Xin, primary, Li, You, additional, Shi, Ting, additional, Bont, Louis J, additional, Chu, Helen Y, additional, Zar, Heather J, additional, Wahi-Singh, Bhanu, additional, Ma, Yiming, additional, Cong, Bingbing, additional, Sharland, Emma, additional, Riley, Richard D, additional, Deng, Jikui, additional, Figueras-Aloy, Josep, additional, Heikkinen, Terho, additional, Jones, Marcus H, additional, Liese, Johannes G, additional, Markić, Joško, additional, Mejias, Asuncion, additional, Nunes, Marta C, additional, Resch, Bernhard, additional, Satav, Ashish, additional, Yeo, Kee Thai, additional, Simões, Eric A F, additional, Nair, Harish, additional, Arruda, Eurico, additional, Baillie, Vicky L, additional, Chong, Debora, additional, Crow, Rowena, additional, Filho, Nelson Rosário, additional, Laubscher, Marius, additional, Madhi, Shabir A, additional, Mrcela, Dina, additional, Ramilo, Octavio, additional, Roje, Damir, additional, Stein, Renato Tetelbom, additional, and Yung, Chee Fu, additional

Published
2024
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24. Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series

Author

Thorburn, Kentigern, Nunes, Marta, Chawana, Richard, Madhi, Shabir A., Vittuci, Anna C., Bassat, Quique, Bardají, Azucena, Goka, Edward, Roglić, Srđan, Paes, Bosco, Elliott, LouAnn, Oshitani, Hitoshi, Lupisan, Socorro, Gentile, Angela, Lucion, María Florencia, Spaeder, Michael C., Butt, Warwick, Thompson, Jenny, Mejias, Asuncion, Ramilo, Octavio, Fasce, Rodrigo A., Werner, Marta, Hijano, Diego R., Allison, Kim J., Pires, Márcia Rosane, de-Paris, Fernanda, Chakhunashvili, Giorgi, Karseladze, Irakli, Otieno, Grieven P., Nokes, D. James, Scheuerman, Oded, Prais, Dario, Amad, Mohammed Al, Serouri, Abdul Wahed Al, Ali, Asad, Yousafzai, Mohammad Tahir, Bruno, Alfredo, de Mora, Domenica, Ojeda, Jenny, Dbaibo, Ghassan, Hanna-Wakim, Rima, Papaevangelou, Vassiliki, Kartisouni, Elpiniki, Cohen, Cheryl, Walaza, Sibongile, Linssen, Rosalie S., Chi, Hsin, Eşki, Aykut, Demir, Esen, Saha, Senjuti, Saha, Samir K, Sochet, Anthony A., Teppa-Sanchez, Beatriz E., Ravindranath, Thyyar M., Baird, J. Scott, Morris, Shaun K., Wong, Waison, Breiman, Robert F., Gurley, Emily S., Arifeen, Shams El, Assefa, Nega, Scott, J. Anthony G., Onyango, Dickens, Kotloff, Karen L., Sow, Samba O., Mandomando, Inacio, Ogbuanu, Ikechukwu U., Jambai, Amara, Kendirli, Tanil, Botan, Edin, Rubio, Franco Díaz, Serra, Alberto, Martinez, Luis, Pedroso, Luis, Menta, Soledad, Pardo, Rosalba, Donoso, Alejandro, Mahmood, Syed Faisal, Khan, Naveera, Löwensteyn, Yvette N, Nair, Harish, Nunes, Marta C, van Roessel, Ichelle, Vernooij, Femke S, Willemsen, Joukje, Bont, Louis J, and Mazur, Natalie I

Published
2021
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29. Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger

Author

Mahajan, Prashant, Kuppermann, Nathan, Mejias, Asuncion, Suarez, Nicolas, Chaussabel, Damien, Casper, T Charles, Smith, Bennett, Alpern, Elizabeth R, Anders, Jennifer, Atabaki, Shireen M, Bennett, Jonathan E, Blumberg, Stephen, Bonsu, Bema, Borgialli, Dominic, Brayer, Anne, Browne, Lorin, Cohen, Daniel M, Crain, Ellen F, Cruz, Andrea T, Dayan, Peter S, Gattu, Rajender, Greenberg, Richard, Hoyle, John D, Jaffe, David M, Levine, Deborah A, Lillis, Kathleen, Linakis, James G, Muenzer, Jared, Nigrovic, Lise E, Powell, Elizabeth C, Rogers, Alexander J, Roosevelt, Genie, Ruddy, Richard M, Saunders, Mary, Tunik, Michael G, Tzimenatos, Leah, Vitale, Melissa, Dean, J Michael, and Ramilo, Octavio

Subjects
Genetics, Infectious Diseases, Pediatric, Clinical Research, Infant Mortality, Infection, Bacteremia, Bacterial Infections, Biomarkers, Case-Control Studies, Diagnostic Tests, Routine, Emergency Service, Hospital, Female, Fever, Genetic Markers, Humans, Infant, Infant, Newborn, Male, Meningitis, Bacterial, Microarray Analysis, Prospective Studies, RNA, Statistics, Nonparametric, Urinary Tract Infections, Pediatric Emergency Care Applied Research Network, Medical and Health Sciences, General & Internal Medicine
Abstract

ImportanceYoung febrile infants are at substantial risk of serious bacterial infections; however, the current culture-based diagnosis has limitations. Analysis of host expression patterns ("RNA biosignatures") in response to infections may provide an alternative diagnostic approach.ObjectiveTo assess whether RNA biosignatures can distinguish febrile infants aged 60 days or younger with and without serious bacterial infections.Design, setting, and participantsProspective observational study involving a convenience sample of febrile infants 60 days or younger evaluated for fever (temperature >38° C) in 22 emergency departments from December 2008 to December 2010 who underwent laboratory evaluations including blood cultures. A random sample of infants with and without bacterial infections was selected for RNA biosignature analysis. Afebrile healthy infants served as controls. Blood samples were collected for cultures and RNA biosignatures. Bioinformatics tools were applied to define RNA biosignatures to classify febrile infants by infection type.ExposureRNA biosignatures compared with cultures for discriminating febrile infants with and without bacterial infections and infants with bacteremia from those without bacterial infections.Main outcomes and measuresBacterial infection confirmed by culture. Performance of RNA biosignatures was compared with routine laboratory screening tests and Yale Observation Scale (YOS) scores.ResultsOf 1883 febrile infants (median age, 37 days; 55.7% boys), RNA biosignatures were measured in 279 randomly selected infants (89 with bacterial infections-including 32 with bacteremia and 15 with urinary tract infections-and 190 without bacterial infections), and 19 afebrile healthy infants. Sixty-six classifier genes were identified that distinguished infants with and without bacterial infections in the test set with 87% (95% CI, 73%-95%) sensitivity and 89% (95% CI, 81%-93%) specificity. Ten classifier genes distinguished infants with bacteremia from those without bacterial infections in the test set with 94% (95% CI, 70%-100%) sensitivity and 95% (95% CI, 88%-98%) specificity. The incremental C statistic for the RNA biosignatures over the YOS score was 0.37 (95% CI, 0.30-0.43).Conclusions and relevanceIn this preliminary study, RNA biosignatures were defined to distinguish febrile infants aged 60 days or younger with vs without bacterial infections. Further research with larger populations is needed to refine and validate the estimates of test accuracy and to assess the clinical utility of RNA biosignatures in practice.

Published
2016

33. 1621. "False-Positive" Cytomegalovirus (CMV) Screening Tests in Neonates: A Real Dilemma!

Author

Lewald, Zachery S, primary, Crisan, Rachelle, additional, Pifer, Traci, additional, De Alba Romero, Conception, additional, Shimamura, Masako, additional, Mejias, Asuncion, additional, Medoro, Alexandra Katherine, additional, Salamon, Doug P, additional, Wang, Huanyu, additional, Leber, Amy, additional, Findlen, Ursula M, additional, Adunka, Oliver, additional, Malhotra, M D S, additional, and Sanchez, Pablo J, additional

Published
2023
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35. 1624. SARS-CoV-2 Maternal Vaccination Induces More Efficient Placental Antibody Transfer to Newborns than SARS-CoV-2 Infection During Pregnancy

Author

Latorre, Leire Pérez, primary, Cohen, Shira H, additional, Rodriguez-Molino, Paula, additional, Kim, Hannah, additional, Eisner, Mariah, additional, Pifer, Traci, additional, Rijal, Manish, additional, Xu, Zhaohui, additional, Costantine, Maged M, additional, Rood, Kara, additional, Abdelwahab, Mahmoud, additional, Reyes, Osvaldo, additional, DeAntonio, Rodrigo, additional, Saez-Llorens, Xavier, additional, Mertz, Sara, additional, Ye, Fang, additional, Jones, Desiree, additional, Bartholomew, Anna, additional, Peeples, Mark E, additional, Sanchez, Pablo J, additional, Mejias, Asuncion, additional, and Ramilo, Octavio, additional

Published
2023
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36. Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data

Author

Altman, Matthew C., Rinchai, Darawan, Baldwin, Nicole, Toufiq, Mohammed, Whalen, Elizabeth, Garand, Mathieu, Syed Ahamed Kabeer, Basirudeen, Alfaki, Mohamed, Presnell, Scott R., Khaenam, Prasong, Ayllón-Benítez, Aaron, Mougin, Fleur, Thébault, Patricia, Chiche, Laurent, Jourde-Chiche, Noemie, Phillips, J. Theodore, Klintmalm, Goran, O’Garra, Anne, Berry, Matthew, Bloom, Chloe, Wilkinson, Robert J., Graham, Christine M., Lipman, Marc, Lertmemongkolchai, Ganjana, Bedognetti, Davide, Thiebaut, Rodolphe, Kheradmand, Farrah, Mejias, Asuncion, Ramilo, Octavio, Palucka, Karolina, Pascual, Virginia, Banchereau, Jacques, and Chaussabel, Damien

Published
2021
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37. Molecular and Clinical Comparison of Enterovirus D68 Outbreaks among Hospitalized Children, Ohio, USA, 2014 and 2018

Author

Wang, Huanyu, Diaz, Alejandro, Moyer, Katherine, Mele-Casas, Maria, Ara-Montojo, Maria Fatima, Torrus, Isabel, McCoy, Karen, Mejias, Asuncion, and Leber, Amy L.

Subjects
Hospital patients -- Comparative analysis, Respiratory tract diseases -- Comparative analysis, Infection -- Comparative analysis, Pediatrics -- Comparative analysis, Phylogeny -- Comparative analysis, Hospital admission and discharge, Pediatric intensive care, Neurologic manifestations, Health, Nationwide Children's Hospital
Abstract

Enterovirus D68 (EV-D68) was originally identified in 1962 in children with severe respiratory tract infections in California, USA (1). The virus shares biological features with enteroviruses and rhinoviruses and was [...]

Published
2019
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38. Mapping systemic lupus erythematosus heterogeneity at the single-cell level

Author

Nehar-Belaid, Djamel, Hong, Seunghee, Marches, Radu, Chen, Guo, Bolisetty, Mohan, Baisch, Jeanine, Walters, Lynnette, Punaro, Marilynn, Rossi, Robert J., Chung, Cheng-Han, Huynh, Richie P., Singh, Prashant, Flynn, William F., Tabanor-Gayle, Joy-Ann, Kuchipudi, Navya, Mejias, Asuncion, Collet, Magalie A., Lucido, Anna Lisa, Palucka, Karolina, Robson, Paul, Lakshminarayanan, Santhanam, Ramilo, Octavio, Wright, Tracey, Pascual, Virginia, and Banchereau, Jacques F.

Published
2020
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39. RNA Transcriptional Biosignature Analysis for Identifying Febrile Infants With Serious Bacterial Infections in the Emergency Department

Author

Mahajan, Prashant, Kuppermann, Nathan, Suarez, Nicolas, Mejias, Asuncion, Casper, Charlie, Dean, J Michael, and Ramilo, Octavio

Subjects
Emergency Care, Health Services, Biotechnology, Clinical Research, Pediatric, Genetics, Infection, Bacterial Infections, Biomarkers, Cohort Studies, Emergency Service, Hospital, Feasibility Studies, Female, Fever, Humans, Infant, Infant, Newborn, Male, Microarray Analysis, Prospective Studies, RNA, febrile infant, serious bacterial infection, RNA transcriptional profiles, microarray, Febrile Infant Working Group for the Pediatric Emergency Care Applied Research Network, Paediatrics and Reproductive Medicine, Emergency & Critical Care Medicine
Abstract

ObjectivesTo develop the infrastructure and demonstrate the feasibility of conducting microarray-based RNA transcriptional profile analyses for the diagnosis of serious bacterial infections in febrile infants 60 days and younger in a multicenter pediatric emergency research network.MethodsWe designed a prospective multicenter cohort study with the aim of enrolling more than 4000 febrile infants 60 days and younger. To ensure success of conducting complex genomic studies in emergency department (ED) settings, we established an infrastructure within the Pediatric Emergency Care Applied Research Network, including 21 sites, to evaluate RNA transcriptional profiles in young febrile infants. We developed a comprehensive manual of operations and trained site investigators to obtain and process blood samples for RNA extraction and genomic analyses. We created standard operating procedures for blood sample collection, processing, storage, shipping, and analyses. We planned to prospectively identify, enroll, and collect 1 mL blood samples for genomic analyses from eligible patients to identify logistical issues with study procedures. Finally, we planned to batch blood samples and determined RNA quantity and quality at the central microarray laboratory and organized data analysis with the Pediatric Emergency Care Applied Research Network data coordinating center. Below we report on establishment of the infrastructure and the feasibility success in the first year based on the enrollment of a limited number of patients.ResultsWe successfully established the infrastructure at 21 EDs. Over the first 5 months we enrolled 79% (74 of 94) of eligible febrile infants. We were able to obtain and ship 1 mL of blood from 74% (55 of 74) of enrolled participants, with at least 1 sample per participating ED. The 55 samples were shipped and evaluated at the microarray laboratory, and 95% (52 of 55) of blood samples were of adequate quality and contained sufficient RNA for expression analysis.ConclusionsIt is possible to create a robust infrastructure to conduct genomic studies in young febrile infants in the context of a multicenter pediatric ED research setting. The sufficient quantity and high quality of RNA obtained suggests that whole blood transcriptional profile analysis for the diagnostic evaluation of young febrile infants can be successfully performed in this setting.

Published
2015

44. Clinical Phenotype of Respiratory Syncytial Virus Bronchiolitis before and during the Coronavirus Disease 2019 Pandemic.

Author

Rodríguez-Fernández, Rosa, González-Martínez, Felipe, Perez-Moreno, Jimena, González-Sánchez, María Isabel, de la Mata Navazo, Sara, Toledo del Castillo, Blanca, Saavedra Lozano, Jesus, Voltas Espinosa, Lucia, Manso Perez, Sara, Miñarro Berlanga, María, Mejias, Asuncion, and Ramilo, Octavio

Subjects
COVID-19, SCIENTIFIC observation, OXYGEN, AGE distribution, RETROSPECTIVE studies, ACQUISITION of data, SEASONS, COMPARATIVE studies, BRONCHIOLE diseases, SYMPTOMS, MEDICAL records, DESCRIPTIVE statistics, RESEARCH funding, RESPIRATORY syncytial virus infections, SOCIODEMOGRAPHIC factors, COVID-19 pandemic, PHENOTYPES, HOSPITAL care of children, CHILDREN
Abstract

Objective The main objective of this report was to comprehensively analyze the clinical characteristics of children hospitalized with respiratory syncytial virus (RSV) infections in 2021 during the coronavirus disease 2019 (COVID-19) pandemic and to compare them with those in the five previous RSV seasons. We hypothesized that the clinical and demographic features of children hospitalized with RSV infection in 2021 were different from those hospitalized in previous respiratory seasons. Study Design In this retrospective observational study, children younger than 2 years hospitalized with RSV bronchiolitis from January 1, 2015, to December 31, 2021, at the Department of Pediatrics of the Hospital Gregorio Marañón, Madrid, Spain, were included. We compared the clinical characteristics of children hospitalized with RSV bronchiolitis in the five seasons before the COVID-19 pandemic and during the subsequent off-seasonal surge of RSV infections. Results We found a significant reduction in hospitalizations for RSV bronchiolitis during the usual winter epidemic period due to the COVID-19 pandemic. Children hospitalized with RSV infection in 2021, during the COVID-19 pandemic, were older than children hospitalized in the prepandemic period (2015–2020; 4.0 [1.6–9.2] vs. 3 [1.5–6.5] months; p < 0.01). We also found shorter duration of oxygen days during the COVID-19 period compared with previous respiratory seasons (3 [2–5] vs. 4 [2–6] days; p = 0.02). Conclusion The COVID-19 pandemic modified the RSV seasonality with a significant reduction in RSV hospitalizations during the expected 2020–2021 season and a reappearance of RSV 7 months later than expected. We also found changes in the median age of children with RSV bronchiolitis during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic compared with the prepandemic RSV seasons and shorter duration of oxygen days suggesting a modest reduction in disease severity. We hypothesize that this observation reflects the lack of RSV circulation in the previous months (April 2020-March 2021), with a larger pool of vulnerable infants that had not been previously infected. Key Points The COVID-19 pandemic shifted RSV seasonality. RSV children hospitalized during the pandemic were older. Modest reduction in disease severity was observed during the pandemic. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Impact of SARS-CoV-2 Infection on Disease Trajectory in Youth with T1D: An EHR-Based Cohort Study from the RECOVER Program

Author

Prahalad, Priya, primary, Lorman, Vitaly, additional, Wu, Qiong, additional, Razzaghi, Hanieh, additional, Chen, Yong, additional, Pajor, Nathan, additional, Case, Abigail, additional, Bose-Brill, Seuli, additional, Block, Jason, additional, Patel, Payal B., additional, Rao, Suchitra, additional, Mejias, Asuncion, additional, Forrest, Christopher B., additional, Bailey, L. Charles, additional, Jhaveri, Ravi, additional, Thacker, Deepika, additional, Christakis, Dimitri A., additional, Lee, Grace M., additional, and Consortium, on behalf of the RECOVER, additional

Published
2023
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47. Differential host responses within the upper respiratory tract and peripheral blood of children and adults with SARS-CoV-2 infection

Author

Hurst, Jillian H, primary, Mohan, Aditya, additional, Dalapati, Trisha, additional, George, Ian A., additional, Aquino, Jhoanna N., additional, Lugo, Debra J., additional, Pfeiffer, Trevor S., additional, Rodriguez, Javier, additional, Rotta, Alexandre T., additional, Turner, Nicholas A., additional, Burke, Thomas W., additional, McClain, Micah T, additional, Henao, Ricardo, additional, DeMarco, C. Todd, additional, Louzao, Raul, additional, Denny, Thomas N., additional, Walsh, Kyle M., additional, Xu, Zhaohui, additional, Mejias, Asuncion, additional, Ramilo, Octavio, additional, Woods, Christopher W., additional, and Kelly, Matthew S, additional

Published
2023
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48. Respiratory Syncytial Virus Seasonality : A Global Overview

Author

Obando-Pacheco, Pablo, Justicia-Grande, Antonio José, Rivero-Calle, Irene, Rodríguez-Tenreiro, Carmen, Sly, Peter, Ramilo, Octavio, Mejías, Asunción, Baraldi, Eugenio, Papadopoulos, Nikolaos G., Nair, Harish, Nunes, Marta C., Kragten-Tabatabaie, Leyla, Heikkinen, Terho, Greenough, Anne, Stein, Renato T., Manzoni, Paolo, Bont, Louis, and Martinón-Torres, Federico

Published
2018

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