27 results on '"Mejía-Villatoro, Carlos"'
Search Results
2. Identification of major routes of HIV transmission throughout Mesoamerica
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Chaillon, Antoine, Avila-Ríos, Santiago, Wertheim, Joel O, Dennis, Ann, García-Morales, Claudia, Tapia-Trejo, Daniela, Mejía-Villatoro, Carlos, Pascale, Juan M, Porras-Cortés, Guillermo, Quant-Durán, Carlos J, Lorenzana, Ivette, Meza, Rita I, Palou, Elsa Y, Manzanero, Marvin, Cedillos, Rolando A, Reyes-Terán, Gustavo, Mehta, Sanjay R, and Group, the Mesoamerican Project
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Microbiology ,Biological Sciences ,Bioinformatics and Computational Biology ,Genetics ,Infectious Diseases ,Sexually Transmitted Infections ,Clinical Research ,HIV/AIDS ,Health Disparities ,2.2 Factors relating to the physical environment ,Infection ,Good Health and Well Being ,Adult ,Central America ,Female ,HIV Infections ,HIV-1 ,Humans ,Male ,Mexico ,Molecular Epidemiology ,Young Adult ,Mesoamerica ,Migration ,Network ,Clusters ,HIV ,Mesoamerican Project Group ,Bioinformatics and computational biology - Abstract
BackgroundMigration and travel are major drivers of the spread of infectious diseases. Geographic proximity and a common language facilitate travel and migration in Mesoamerica, which in turn could affect the spread of HIV in the region.Methods6092 HIV-1 subtype B partial pol sequences sampled from unique antiretroviral treatment-naïve individuals from Mexico (40.7%), Guatemala (24.4%), Honduras (19%), Panama (8.2%), Nicaragua (5.5%), Belize (1.4%), and El Salvador (0.7%) between 2011 and 2016 were included. Phylogenetic and genetic network analyses were performed to infer putative relationships between HIV sequences. The demographic and geographic associations with clustering were analyzed and viral migration patterns were inferred using the Slatkin-Maddison approach on 100 iterations of random subsets of equal number of sequences per location.ResultsA total of 1685/6088 (27.7%) of sequences linked with at least one other sequence, forming 603 putative transmission clusters (range: 2-89 individuals). Clustering individuals were significantly more likely to be younger (median age 29 vs 33years, p10 individuals, including two comprised exclusively of Guatemalans (52 and 89 individuals). Phylogenetic and migration analyses suggested that the Central and Southern regions of Mexico along with Belize were major sources of HIV throughout the region (p
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- 2017
3. Potential for immune-driven viral polymorphisms to compromise antiretroviral-based preexposure prophylaxis for prevention of HIV-1 infection
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Gatanaga, Hiroyuki, Brumme, Zabrina L, Adland, Emily, Reyes-Terán, Gustavo, Avila-Rios, Santiago, Mejía-Villatoro, Carlos R, Hayashida, Tsunefusa, Chikata, Takayuki, Van Tran, Giang, Van Nguyen, Kinh, Meza, Rita I, Palou, Elsa Y, Valenzuela-Ponce, Humberto, Pascale, Juan M, Porras-Cortés, Guillermo, Manzanero, Marvin, Lee, Guinevere Q, Martin, Jeffrey N, Carrington, Mary N, John, Mina, Mallal, Simon, Poon, Art FY, Goulder, Philip, Takiguchi, Masafumi, and Oka, Shinichi
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Medical Microbiology ,Biomedical and Clinical Sciences ,Immunology ,Prevention ,HIV/AIDS ,Sexually Transmitted Infections ,Genetics ,Infectious Diseases ,2.4 Surveillance and distribution ,Aetiology ,Infection ,Anti-Retroviral Agents ,Drug Resistance ,Viral ,Global Health ,HIV Infections ,HIV Reverse Transcriptase ,HIV-1 ,HLA-B18 Antigen ,Humans ,Immune Evasion ,Mutation ,Missense ,Polymorphism ,Genetic ,Pre-Exposure Prophylaxis ,Rilpivirine ,E138X ,escape mutation ,human leukocyte antigen-B*18 ,replication fitness ,rilpivirine ,International HIV Adaptation Collaborative ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Virology ,Biomedical and clinical sciences ,Health sciences - Abstract
ObjectiveLong-acting rilpivirine is a candidate for preexposure prophylaxis (PrEP) for prevention of HIV-1 infection. However, rilpivirine resistance mutations at reverse transcriptase codon 138 (E138X) occur naturally in a minority of HIV-1-infected persons; in particular those expressing human leukocyte antigen (HLA)-B18 where reverse transcriptase-E138X arises as an immune escape mutation. We investigate the global prevalence, B18-linkage and replicative cost of reverse transcriptase-E138X and its regional implications for rilpivirine PrEP.MethodsWe analyzed linked reverse transcriptase-E138X/HLA data from 7772 antiretroviral-naive patients from 16 cohorts spanning five continents and five HIV-1 subtypes, alongside unlinked global reverse transcriptase-E138X and HLA frequencies from public databases. E138X-containing HIV-1 variants were assessed for in-vitro replication as a surrogate of mutation stability following transmission.ResultsReverse transcriptase-E138X variants, where the most common were rilpivirine resistance-associated mutations E138A/G/K, were significantly enriched in HLA-B18-positive individuals globally (P = 3.5 × 10) and in all HIV-1 subtypes except A. Reverse transcriptase-E138X and B18 frequencies correlated positively in 16 cohorts with linked HIV/HLA genotypes (Spearman's R = 0.75; P = 7.6 × 10) and in unlinked HIV/HLA data from 43 countries (Spearman's R = 0.34, P = 0.02). Notably, reverse transcriptase-E138X frequencies approached (or exceeded) 10% in key epidemic regions (e.g. sub-Saharan Africa, Southeastern Europe) where B18 is more common. This, along with the observation that reverse transcriptase-E138X variants do not confer in-vitro replicative costs, supports their persistence, and ongoing accumulation in circulation over time.ConclusionsResults illustrate the potential for a natural immune-driven HIV-1 polymorphism to compromise antiretroviral-based prevention, particularly in key epidemic regions. Regional reverse transcriptase-E138X surveillance should be undertaken before use of rilpivirine PrEP.
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- 2017
4. Accuracy of the tuberculosis point-of-care Alere determine lipoarabinomannan antigen diagnostic test using α-mannosidase treated and untreated urine in a cohort of people living with HIV in Guatemala
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García, Juan Ignacio, Meléndez, Johanna, Álvarez, Rosa, Mejía-Chew, Carlos, Kelley, Holden V., Sidiki, Sabeen, Castillo, Alejandra, Mazariegos, Claudia, López-Téllez, Cesar, Forno, Diana, Ayala, Nancy, Balada-Llasat, Joan-Miquel, Mejía-Villatoro, Carlos Rodolfo, Wang, Shu-Hua, Torrelles, Jordi B., and Ikeda, Janet
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- 2020
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5. Improved Alere Determine Lipoarabinomannan Antigen Detection Test for the Diagnosis of Human and Bovine Tuberculosis by Manipulating Urine and Milk
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García, Juan Ignacio, Kelley, Holden V., Meléndez, Johanna, de León, Rosa Alejandra Alvarez, Castillo, Alejandra, Sidiki, Sabeen, Yusoof, Kizil A., Nunes, Elizabete, Téllez, Cesar López, Mejía-Villatoro, Carlos Rodolfo, Ikeda, Janet, García-Basteiro, Alberto L., Wang, Shu-Hua, and Torrelles, Jordi B.
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- 2019
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6. Prevalencia y patrones de farmacorresistencia transmitida del VIH en Guatemala
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Avila-Ríos, Santiago, Mejía-Villatoro, Carlos R., García-Morales, Claudia, Soto-Nava, Maribel, Escobar, Ingrid, Mendizabal, Ricardo, Girón, Amalia, García, Leticia, and Reyes-Terán, Gustavo
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- 2011
7. Staphylococcus aureus bloodstream infections in Latin America: results of a multinational prospective cohort study
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Seas, Carlos, Garcia, Coralith, Salles, Mauro J., Labarca, Jaime, Luna, Carlos, Latin American Working Group on Antimicrobial Resistance, Mejía-Villatoro, Carlos, Zurita, Jeannete, Guzmán-Blanco, Manuel, Rodrıguez-Noriega, Eduardo, Reyes, Jinnethe, Alvarez-Moreno, Carlos, Carcamo, César, Gotuzzo, Eduardo, Hidalgo, José, and Arias, César A.
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América Latina ,Bacteriemia ,Enfermedades infecciosas ,purl.org/pe-repo/ocde/ford#3.05.00 [https] - Abstract
En América Latina ocurre una heterogeneidad sustancial en la epidemiología y manejo de bacteriemia de Staphylococcus aureus. Se condujo un estudio prospectivo en 24 hospitales de nueve países de América Latina para evaluar el impacto clínico de la bacteriemia de Staphylococcus aureus.
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- 2018
8. P074 HLA class i allele frequencies and haplotype structures in HIV-infected individuals from Guatemala
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Valenzuela-Ponce, Humberto, primary, Alva-Hernández, Selma, additional, Soto-Nava, Maribel, additional, Mejía-Villatoro, Carlos, additional, Escobar-Urias, Ingrid Y., additional, Pinzón-Meza, Rodolfo, additional, Ávila-Ríos, Santiago, additional, and Reyes-Terán, Gustavo, additional
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- 2019
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9. Staphylococcus aureus bloodstream infections in Latin America: results of a multinational prospective cohort study
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Seas, Carlos, Garcia, Coralith, Costa Salles, Mauro José, Labarca, Jaime A., Luna, Carlos Marcelo, Alvarez Moreno, Carlos Arturo, Mejía-Villatoro, Carlos Rodolfo, Zurita, Jeannete, Guzmán-Blanco, Manuel, Rodríguez-Noriega, Eduardo, Reyes, Jinnethe, Arias, César A., Ćarcamo, César Paul, Gotuzzo, Eduardo H., Bruno, Didier, Efrón, Ernesto D., del Castillo, Marcelo, Dei, Sanatorio Mater, Guimarães, Thaís, Ceballos, María Elena, Domínguez, Isabel, Riedel, Gisela, Valderrama, Sandra, Gualtero, Sandra Milena, Saavedra, Carlos Humberto, Tello, Betzabé, Guerrero, Fausto, Silvestre, María Mónica, Morfin-Otero, Rayo, Alcalde, Fray Antonio, Hidalgo, José A., Hercilla, Luis, Silva, Marisela, and Guzmán, Alfonso José
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0301 basic medicine ,Male ,methicillin-resistant staphylococcus aureus infection ,bloodstream infections ,methicillin-susceptible staphylococcus aureus ,Bacteremia ,medicine.disease_cause ,Cohort Studies ,sensitivity analysis ,Epidemiology ,follow-up ,Pharmacology (medical) ,Blood culture ,Prospective Studies ,lactams ,Prospective cohort study ,Original Research ,Cross Infection ,medicine.diagnostic_test ,Middle Aged ,Staphylococcal Infections ,per protocol analysis ,Anti-Bacterial Agents ,Infectious Diseases ,Female ,epidemiology ,Cohort study ,Microbiology (medical) ,Methicillin-Resistant Staphylococcus aureus ,staphylococcus aureus ,medicine.medical_specialty ,030106 microbiology ,Estudios de cohortes ,methicillin-resistant staphylococcus aureus ,purl.org/pe-repo/ocde/ford#3.03.08 [https] ,03 medical and health sciences ,length of stay ,Vancomycin ,Internal medicine ,medicine ,Humans ,purl.org/pe-repo/ocde/ford#3.01.05 [https] ,bacteremia ,purl.org/pe-repo/ocde/ford#1.06.01 [https] ,Pharmacology ,Intention-to-treat analysis ,business.industry ,latin america ,medicine.disease ,Methicillin-resistant Staphylococcus aureus ,mortality ,prospective studies ,Surgery ,Latin America ,Blood Culture ,Relative risk ,Mortalidad ,heterogeneity ,business - Abstract
Background: Substantial heterogeneity in the epidemiology and management of Staphylococcus aureus bacteraemia (SAB) occurs in Latin America. We conducted a prospective cohort study in 24 hospitals from nine Latin American countries. Objectives: To assess the clinical impact of SAB in Latin America. Patients and methods: We evaluated differences in the 30 day attributable mortality among patients with SAB due to MRSA compared with MSSA involving 84 days of follow-up. Adjusted relative risks were calculated using a generalized linear model. Results: A total of 1030 patients were included. MRSA accounted for 44.7% of cases with a heterogeneous geographical distribution. MRSA infection was associated with higher 30 day attributable mortality [25% (78 of 312) versus 13.2% (48 of 363), adjusted RR: 1.94, 95% CI: 1.38–2.73, P
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- 2017
10. Evolutionary history and spatiotemporal dynamics of the HIV-1 subtype B epidemic in Guatemala
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Mendoza, Yaxelis, primary, García-Morales, Claudia, additional, Bello, Gonzalo, additional, Garrido-Rodríguez, Daniela, additional, Tapia-Trejo, Daniela, additional, Pascale, Juan Miguel, additional, Girón-Callejas, Amalia Carolina, additional, Mendizábal-Burastero, Ricardo, additional, Escobar-Urias, Ingrid Yessenia, additional, García-González, Blanca Leticia, additional, Navas-Castillo, Jessenia Sabrina, additional, Quintana-Galindo, María Cristina, additional, Pinzón-Meza, Rodolfo, additional, Mejía-Villatoro, Carlos Rodolfo, additional, Avila-Ríos, Santiago, additional, and Reyes-Terán, Gustavo, additional
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- 2018
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11. Optimizing resources to reduce costs to determine HIV viral load in limited resources settings
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Girón-Callejas, Amalia, primary, Mendizabal-Burastero, Ricardo, additional, Yax, Elizabeth, additional, Martínez, Axel, additional, and Mejía-Villatoro, Carlos, additional
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- 2017
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12. Identification of major routes of HIV transmission throughout Mesoamerica.
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Dennis, Ann, Dennis, Ann, García-Morales, Claudia, Tapia-Trejo, Daniela, Mejía-Villatoro, Carlos, Pascale, Juan, Porras-Cortés, Guillermo, Quant-Durán, Carlos, Lorenzana, Ivette, Meza, Rita, Palou, Elsa, Manzanero, Marvin, Cedillos, Rolando, Reyes-Terán, Gustavo, Avila-Ríos, Santiago, Wertheim, Joel, Chaillon, Antoine, Mehta, Sanjay, Dennis, Ann, Dennis, Ann, García-Morales, Claudia, Tapia-Trejo, Daniela, Mejía-Villatoro, Carlos, Pascale, Juan, Porras-Cortés, Guillermo, Quant-Durán, Carlos, Lorenzana, Ivette, Meza, Rita, Palou, Elsa, Manzanero, Marvin, Cedillos, Rolando, Reyes-Terán, Gustavo, Avila-Ríos, Santiago, Wertheim, Joel, Chaillon, Antoine, and Mehta, Sanjay
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BACKGROUND: Migration and travel are major drivers of the spread of infectious diseases. Geographic proximity and a common language facilitate travel and migration in Mesoamerica, which in turn could affect the spread of HIV in the region. METHODS: 6092 HIV-1 subtype B partial pol sequences sampled from unique antiretroviral treatment-naïve individuals from Mexico (40.7%), Guatemala (24.4%), Honduras (19%), Panama (8.2%), Nicaragua (5.5%), Belize (1.4%), and El Salvador (0.7%) between 2011 and 2016 were included. Phylogenetic and genetic network analyses were performed to infer putative relationships between HIV sequences. The demographic and geographic associations with clustering were analyzed and viral migration patterns were inferred using the Slatkin-Maddison approach on 100 iterations of random subsets of equal number of sequences per location. RESULTS: A total of 1685/6088 (27.7%) of sequences linked with at least one other sequence, forming 603 putative transmission clusters (range: 2-89 individuals). Clustering individuals were significantly more likely to be younger (median age 29 vs 33years, p<0.01) and men-who-have-sex-with-men (40.4% vs 30.3%, p<0.01). Of the 603 clusters, 30 (5%) included sequences from multiple countries with commonly observed linkages between Mexican and Honduran sequences. Eight of the 603 clusters included >10 individuals, including two comprised exclusively of Guatemalans (52 and 89 individuals). Phylogenetic and migration analyses suggested that the Central and Southern regions of Mexico along with Belize were major sources of HIV throughout the region (p<0.01) with genetic flow southward from Mexico to the other nations of Mesoamerica. We also found evidence of significant viral migration within Mexico. CONCLUSION: International clusters were infrequent, suggesting moderate migration between HIV epidemics of the different Mesoamerican countries. Nevertheless, we observed important sources of transnational HIV spread
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- 2017
13. Optimizing resources to reduce costs to determine HIV viral load in limited resources settings
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Girón-Callejas, Amalia, Mendizabal-Burastero, Ricardo, Yax, Elizabeth, Martínez, Axel, Mejía-Villatoro, Carlos, Girón-Callejas, Amalia, Mendizabal-Burastero, Ricardo, Yax, Elizabeth, Martínez, Axel, and Mejía-Villatoro, Carlos
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Introduction: HIV viral load testing is a key factor to evaluate the accomplishment of the UNAIDS target of 90% of viral suppression among people receiving antiretroviral therapy. Pooled samples are a potentially accurate and economic approach in resource-constrained settings, but efficiency can be negatively affected by high prevalence rates of virological failure.Objective: Strategies were assessed to increase the relative efficiency of pooled HIV viral load testing in resource-constrained settings.Materials and methods: We evaluated two strategies: a) plasma samples were not included in pools if patients had <12 months on antiretroviral therapy, patients had previous viral load >1,000 copies/ml, or were antiretroviral therapy naïve patients, and b) plasma pools were organized separately for first and second-line antiretroviral therapy regimens. Individual viral load tests were used to compare pooled results.Results: Negative predictive values were similar for patients on first (100.0%; 95% CI 99.5 to 100.0) and second-line antiretroviral therapy regimens (99.4%; 95% CI 96.9 to 99.9). However, the incidence of virological failure among individuals on first-line antiretroviral therapy was lower than second-line antiretroviral therapy patients (p <0.01), resulting in greater savings in laboratory tests in patients on first-line antiretroviral therapy (74.0%; 95% CI 71.0 to 76.7) compared with the group of patients on second-line antiretroviral therapy (50.9%; 95% CI 44.4 to 57.3) (p<0.01).Conclusion: Selecting the samples to be included in the pools and selecting the pools according to ART regimens are criteria that could lead to decreased spending on laboratory tests for HIV viral load determination in resource-constrained settings., Introducción. Las metas globales para controlar la epidemia de HIV contemplan que la carga viral sea indetectable en 90 % de las personas en tratamiento. El costo de la medición de la carga viral en lotes de muestras puede reducirse y, así, aumentar la cobertura cuando los recursos son limitados; sin embargo, su eficacia disminuye al aumentar la prevalencia del fracaso del tratamiento antirretroviral.Objetivo. Evaluar estrategias para disminuir la proporción de pacientes con fracaso del tratamiento anti-rretroviral en los lotes de muestras y, de esta manera, aumentar el ahorro en las pruebas de carga viral.Materiales y métodos. Las estrategias evaluadas fueron: a) la organización de los lotes de muestras según el esquema de tratamiento antirretroviral, y b) la exclusión de aquellos pacientes con antecedente reciente de fracaso del tratamiento antirretroviral, aquellos con menos de 12 meses de tratamiento antirretroviral y aquellos sin tratamiento antirretroviral previo. Los resultados de los lotes se compararon con los resultados individuales.Resultados. El valor diagnóstico negativo fue similar para los pacientes con esquema de primera línea (100,0 %; IC95% 99,5-100,0) o de segunda línea de tratamiento (99,4 %; IC95% 96,9-99,9). La incidencia del fracaso del tratamiento antirretroviral fue menor en los pacientes con tratamiento de primera línea (p<0,01), lo cual permitió un mayor ahorro en las pruebas de laboratorio en este grupo (74,0 %; IC95% 71,0-76,7) que en los pacientes con tratamiento de segunda línea (50,9 %; IC95% 44,4-57,3) (p<0,01).Conclusión. La selección de las muestras que se incluyeron en los lotes para determinar la carga viral del HIV según el tipo de esquema de tratamiento, permitió maximizar el porcentaje de ahorro en pruebas de laboratorio.
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- 2017
14. Identification of major routes of HIV transmission throughout Mesoamerica
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Chaillon, Antoine, primary, Avila-Ríos, Santiago, additional, Wertheim, Joel O., additional, Dennis, Ann, additional, García-Morales, Claudia, additional, Tapia-Trejo, Daniela, additional, Mejía-Villatoro, Carlos, additional, Pascale, Juan M., additional, Porras-Cortés, Guillermo, additional, Quant-Durán, Carlos J., additional, Lorenzana, Ivette, additional, Meza, Rita I., additional, Palou, Elsa Y., additional, Manzanero, Marvin, additional, Cedillos, Rolando A., additional, Reyes-Terán, Gustavo, additional, and Mehta, Sanjay R., additional
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- 2017
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15. Perfil de resistencia del VIH-1 a anti-retrovirales en pacientes con fallo virològico: Hospital Roosevelt-Guatemala 2008-2012
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Mendizábal-Burastero, Ricardo, Girón-Callejas, Amalia C, Rodas-Cruz, Jorge A, Pinzón, Rodolfo, Romero, M. Lisbeth, Boror, E. Marisol, and Mejía-Villatoro, Carlos R
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Anti-Retroviral Agents ,anti-retrovirales ,Mutation ,HIV-1 ,Drug Resistance ,Viral ,resistencia secundaria ,Guatemala ,VIH-1 ,mutación - Abstract
Objetivo: Evaluar el perfil de resistencia secundaria del VIH-1 a anti-retrovirales (ARV) en pacientes con fallo virológico en la clínica de atención integral más grande de Guatemala. Métodos: Uso de Stanford HIV Database para análisis de secuencias pol para perfiles de resistencia de VIH en pacientes con fallo virológico al primer esquema ARV o fallo múltiple (dos o más esquemas ARV fallidos), entre los años 2008 y 2012. Determinación de proporciones y análisis de riesgo. Resultados: Evidencia de resistencia de 83% (n: 43) en primer fallo y 75% (n: 30) en fallo múltiple. La mayor frecuencia de resistencia se presentó en los inhibidores-no-nucleosídicos (70%). Cuarenta y cuatro por ciento (n: 42) evidenció resistencia a dos familias de ARV y 4% (n: 4) a las tres familias. Pacientes con primer fallo tuvieron más riesgo de resistencia a inhibidores-nucleosídicos (OR: 3,0; IC 95% 1,29-6,98) y más riesgo de multi-resistencia (OR: 4,94; IC 95% 1,98-12,32). Mutaciones más frecuentes fueron: M184V, K103N y K65R (71, 50 y 22%, respectivamente). Setenta por ciento de los pacientes con primer fallo presentaron resistencia a al menos uno de los medicamentos utilizado como segunda línea en Guatemala (ABC/ddI/AZT). Conclusiones: El alto nivel de resistencia del VIH-1 a los ARV observada, sugiere la necesidad de modificar el actual esquema terapéutico de rescate en Guatemala y la importancia de realizar genotipificación viral en todos los pacientes con fallo al primer esquema. Objective: To assess the secondary resistance patterns of HIV-1to Anti-Retroviral Agents drugs (ART) in patients with virological failure in the main HIV care center in Guatemala. Methods: Using the Stanford HIV Database,HIV pol sequences were analyzed to obtain resistance patterns in patients with first-failure to ART or multiple-failures (2 or more regimens failed), from 2008 to 2012. Proportions and odds ratio (OR) with 95% confidence intervals (95%CI) were calculated. Results: 83% (43) in the first-failure and 75% (30) in multiple-failures had resistance. The highest frequency (70%)of resistance was found in the non-nucleoside-inhibitors ART family. 44% (42) showed resistance to two ART families and 4% (4) to the three families. First-failure patients had higher risk of nucleoside-inhibitor resistance (OR:3.0, 95%CI 1.29-6.98) and multidrug resistance (OR:4.94, 95%CI 1.98-12.32). Most frequent mutations were: M184V, K103N and K65R (71, 50 and 22%, respectively). 70% of patients with first-failure were resistant to at least one of the drugs used as second ART in Guatemala (ABC, ddI or AZT). Conclusions: The high level of HIV-1 resistance to ART observed, suggest the need to amend the current second line regimen treatments in Guatemala and the importance of viral genotyping in all patients with first-failure to ART.
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- 2013
16. Characterization and Clinical Impact of Bloodstream Infection Caused by Carbapenemase-Producing Enterobacteriaceae in Seven Latin American Countries
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Villegas, Maria Virginia, primary, Pallares, Christian J., additional, Escandón-Vargas, Kevin, additional, Hernández-Gómez, Cristhian, additional, Correa, Adriana, additional, Álvarez, Carlos, additional, Rosso, Fernando, additional, Matta, Lorena, additional, Luna, Carlos, additional, Zurita, Jeannete, additional, Mejía-Villatoro, Carlos, additional, Rodríguez-Noriega, Eduardo, additional, Seas, Carlos, additional, Cortesía, Manuel, additional, Guzmán-Suárez, Alfonso, additional, and Guzmán-Blanco, Manuel, additional
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- 2016
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17. Optimización de recursos para determinar la carga viral de HIV-1 en un país con pocos recursos.
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Girón-Callejas, Amalia, Mendizábal-Burastero, Ricardo, Yax, Elizabeth, Martínez, Axel, and Mejía-Villatoro, Carlos
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Copyright of Biomédica: Revista del Instituto Nacional de Salud is the property of Instituto Nacional de Salud of Colombia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2017
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18. O331: HIV drug resistance in treatment-naïve individuals in Mesoamerica
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Avila-Rios, Santiago, primary, García-Morales, Claudia, additional, Tapia-Trejo, Daniela, additional, Mejía-Villatoro, Carlos, additional, Pascale, Juan, additional, Porras-Cortes, Guillermo, additional, Lorenzana, Ivette, additional, Palou, Elsa, additional, Manzanero, Marvin, additional, and Reyes-Terán, Gustavo, additional
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- 2015
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19. HIV-1 Drug Resistance Surveillance in Antiretroviral Treatment-Naive Individuals from a Reference Hospital in Guatemala, 2010–2013
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Avila-Ríos, Santiago, primary, García-Morales, Claudia, additional, Garrido-Rodríguez, Daniela, additional, Tapia-Trejo, Daniela, additional, Girón-Callejas, Amalia Carolina, additional, Mendizábal-Burastero, Ricardo, additional, Escobar-Urias, Ingrid Yessenia, additional, García-González, Blanca Leticia, additional, Navas-Castillo, Sabrina, additional, Pinzón-Meza, Rodolfo, additional, Mejía-Villatoro, Carlos Rodolfo, additional, and Reyes-Terán, Gustavo, additional
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- 2015
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20. Potential for immune-driven viral polymorphisms to compromise antiretroviral-based preexposure prophylaxis for prevention of HIV-1 infection.
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Hiroyuki Gatanaga, Brumme, Zabrina L., Adland, Emily, Reyes-Terán, Gustavo, Avila-Rios, Santiago, Mejía-Villatoro, Carlos R., Tsunefusa Hayashida, Takayuki Chikata, Giang Van Tran, Kinh Van Nguyen, Meza, Rita I., Palou, Elsa Y., Gatanaga, Hiroyuki, Hayashida, Tsunefusa, Chikata, Takayuki, Van Tran, Giang, Van Nguyen, Kinh, Valenzuela-Ponce, Humberto, Pascale, Juan M, and Porras-Cortés, Guillermo
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- 2017
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21. Perfil de resistencia del VIH-1 a anti-retrovirales en pacientes con fallo virològico: Hospital Roosevelt-Guatemala 2008-2012
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Mendizábal-Burastero, Ricardo, primary, Girón-Callejas, Amalia C, additional, Rodas-Cruz, Jorge A, additional, Pinzón, Rodolfo, additional, Romero, M. Lisbeth, additional, Boror, E. Marisol, additional, and Mejía-Villatoro, Carlos R, additional
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- 2013
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22. Prevalence and patterns of HIV transmitted drug resistance in Guatemala
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Avila-Ríos, Santiago, primary, Mejía-Villatoro, Carlos R., additional, García-Morales, Claudia, additional, Soto-Nava, Maribel, additional, Escobar, Ingrid, additional, Mendizabal, Ricardo, additional, Girón, Amalia, additional, García, Leticia, additional, and Reyes-Terán, Gustavo, additional
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- 2011
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23. Factores de riesgo cardiovascular en pacientes con virus de la inmunodeficiencia humana en Guatemala.
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Roberto Mejía Chew, Carlos, Pennington Rueda, Joan, and Rodolfo Mejía Villatoro, Carlos
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CARDIOVASCULAR diseases risk factors ,HIV-positive persons ,DISEASE prevalence ,HIV infections ,HIGHLY active antiretroviral therapy - Abstract
Copyright of Revista Panamericana de Infectología is the property of Asociacion Panamericana de Infectologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2012
24. Characterization and clinical impact of bloodstream infection caused by carbapenemase-producing enterobacteriaceae in seven Latin American countries
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Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Grupo de Investigación en Enfermedades Infecciosas HUSI - PUJ, Villegas, Maria Virginia, Pallares, Christian J., Escandón-Vargas, Kevin, Hernández-Gómez, Cristhian, Correa, Adriana, Álvarez Moreno, Carlos Arturo, Rosso, Fernando, Matta, Lorena, Luna, Carlos, Zurita, Jeannete, Mejía-Villatoro, Carlos, Rodríguez-Noriega, Eduardo, Seas, Carlos, Cortesía, Manuel, Guzmán-Suárez, Alfonso, Guzmán-Blanco, Manuel, Pontificia Universidad Javeriana. Facultad de Medicina. Departamento de Medicina Interna. Grupo de Investigación en Enfermedades Infecciosas HUSI - PUJ, Villegas, Maria Virginia, Pallares, Christian J., Escandón-Vargas, Kevin, Hernández-Gómez, Cristhian, Correa, Adriana, Álvarez Moreno, Carlos Arturo, Rosso, Fernando, Matta, Lorena, Luna, Carlos, Zurita, Jeannete, Mejía-Villatoro, Carlos, Rodríguez-Noriega, Eduardo, Seas, Carlos, Cortesía, Manuel, Guzmán-Suárez, Alfonso, and Guzmán-Blanco, Manuel
25. Novel HLA class I associations with HIV-1 control in a unique genetically admixed population.
- Author
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Valenzuela-Ponce H, Alva-Hernández S, Garrido-Rodríguez D, Soto-Nava M, García-Téllez T, Escamilla-Gómez T, García-Morales C, Quiroz-Morales VS, Tapia-Trejo D, Del Arenal-Sánchez S, Prado-Galbarro FJ, Hernández-Juan R, Rodríguez-Aguirre E, Murakami-Ogasawara A, Mejía-Villatoro C, Escobar-Urias IY, Pinzón-Meza R, Pascale JM, Zaldivar Y, Porras-Cortés G, Quant-Durán C, Lorenzana I, Meza RI, Palou EY, Manzanero M, Cedillos RA, Aláez C, Brockman MA, Harrigan PR, Brumme CJ, Brumme ZL, Ávila-Ríos S, and Reyes-Terán G
- Subjects
- Adult, Canada epidemiology, Central America epidemiology, Cohort Studies, Female, Gene Frequency, Genetics, Population, Genotype, HIV Infections epidemiology, Humans, Linkage Disequilibrium, Male, Mexico epidemiology, Polymorphism, Genetic, Young Adult, HIV Infections genetics, HIV-1 isolation & purification, HLA Antigens genetics
- Abstract
Associations between HLA class I alleles and HIV progression in populations exhibiting Amerindian and Caucasian genetic admixture remain understudied. Using univariable and multivariable analyses we evaluated HLA associations with five HIV clinical parameters in 3,213 HIV clade B-infected, ART-naïve individuals from Mexico and Central America (MEX/CAM cohort). A Canadian cohort (HOMER, n = 1622) was used for comparison. As expected, HLA allele frequencies in MEX/CAM and HOMER differed markedly. In MEX/CAM, 13 HLA-A, 24 HLA-B, and 14 HLA-C alleles were significantly associated with at least one clinical parameter. These included previously described protective (e.g. B*27:05, B*57:01/02/03 and B*58:01) and risk (e.g. B*35:02) alleles, as well as novel ones (e.g. A*03:01, B*15:39 and B*39:02 identified as protective, and A*68:03/05, B*15:30, B*35:12/14, B*39:01/06, B*39:05~C*07:02, and B*40:01~C*03:04 identified as risk). Interestingly, both protective (e.g. B*39:02) and risk (e.g. B*39:01/05/06) subtypes were identified within the common and genetically diverse HLA-B*39 allele group, characteristic to Amerindian populations. While HLA-HIV associations identified in MEX and CAM separately were similar overall (Spearman's rho = 0.33, p = 0.03), region-specific associations were also noted. The identification of both canonical and novel HLA/HIV associations provides a first step towards improved understanding of HIV immune control among unique and understudied Mestizo populations.
- Published
- 2018
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26. Staphylococcus aureus bloodstream infections in Latin America: results of a multinational prospective cohort study.
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Seas C, Garcia C, Salles MJ, Labarca J, Luna C, Alvarez-Moreno C, Mejía-Villatoro C, Zurita J, Guzmán-Blanco M, Rodríguez-Noriega E, Reyes J, Arias CA, Carcamo C, and Gotuzzo E
- Subjects
- Anti-Bacterial Agents therapeutic use, Bacteremia drug therapy, Bacteremia microbiology, Blood Culture, Cohort Studies, Cross Infection drug therapy, Cross Infection microbiology, Female, Humans, Latin America epidemiology, Male, Methicillin-Resistant Staphylococcus aureus drug effects, Middle Aged, Prospective Studies, Staphylococcal Infections drug therapy, Staphylococcal Infections mortality, Vancomycin therapeutic use, Bacteremia epidemiology, Cross Infection epidemiology, Methicillin-Resistant Staphylococcus aureus isolation & purification, Staphylococcal Infections epidemiology
- Abstract
Background: Substantial heterogeneity in the epidemiology and management of Staphylococcus aureus bacteraemia (SAB) occurs in Latin America. We conducted a prospective cohort study in 24 hospitals from nine Latin American countries., Objectives: To assess the clinical impact of SAB in Latin America., Patients and Methods: We evaluated differences in the 30 day attributable mortality among patients with SAB due to MRSA compared with MSSA involving 84 days of follow-up. Adjusted relative risks were calculated using a generalized linear model., Results: A total of 1030 patients were included. MRSA accounted for 44.7% of cases with a heterogeneous geographical distribution. MRSA infection was associated with higher 30 day attributable mortality [25% (78 of 312) versus 13.2% (48 of 363), adjusted RR: 1.94, 95% CI: 1.38-2.73, P < 0.001] compared with MSSA in the multivariable analysis based on investigators' assessment, but not in a per-protocol analysis [13% (35 of 270) versus 8.1% (28 of 347), adjusted RR: 1.10, 95% CI: 0.75-1.60, P = 0.616] or in a sensitivity analysis using 30 day all-cause mortality [36% (132 of 367) versus 27.8% (123 of 442), adjusted RR: 1.09, 95% CI: 0.96-1.23, P = 0.179]. MRSA infection was not associated with increased length of hospital stay. Only 49% of MSSA bloodstream infections (BSI) received treatment with β-lactams, but appropriate definitive treatment was not associated with lower mortality (adjusted RR: 0.93, 95% CI: 0.70-1.23, P = 0.602)., Conclusions: MRSA-BSIs in Latin America are not associated with higher 30 day mortality or longer length of stay compared with MSSA. Management of MSSA-BSIs was not optimal, but appropriate definitive therapy did not appear to influence mortality., (© The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2018
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27. [Patterns of HIV-1 resistance to antiretroviral drugs in patients with virologic failure: Roosevelt Hospital, Guatemala 2008-2012].
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Mendizábal-Burastero R, Girón-Callejas AC, Rodas-Cruz JA, Pinzón R, Romero ML, Boror EM, and Mejía-Villatoro CR
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- Adult, CD4 Lymphocyte Count, Female, Genotype, Guatemala, HIV Infections drug therapy, HIV-1 genetics, Humans, Male, Retrospective Studies, Treatment Failure, Viral Load, Anti-HIV Agents therapeutic use, Drug Resistance, Viral genetics, HIV Infections virology, HIV-1 drug effects, Mutation genetics
- Abstract
Objective: To assess the secondary resistance patterns of HIV-1to Anti-Retroviral Agents drugs (ART) in patients with virological failure in the main HIV care center in Guatemala., Methods: Using the Stanford HIV Database,HIV pol sequences were analyzed to obtain resistance patterns in patients with first-failure to ART or multiple-failures (2 or more regimens failed), from 2008 to 2012. Proportions and odds ratio (OR) with 95% confidence intervals (95%CI) were calculated., Results: 83% (43) in the first-failure and 75% (30) in multiple-failures had resistance. The highest frequency (70%)of resistance was found in the non-nucleoside-inhibitors ART family. 44% (42) showed resistance to two ART families and 4% (4) to the three families. First-failure patients had higher risk of nucleoside-inhibitor resistance (OR:3.0, 95%CI 1.29-6.98) and multidrug resistance (OR:4.94, 95%CI 1.98-12.32). Most frequent mutations were: M184V, K103N and K65R (71, 50 and 22%, respectively). 70% of patients with first-failure were resistant to at least one of the drugs used as second ART in Guatemala (ABC, ddI or AZT)., Conclusions: The high level of HIV-1 resistance to ART observed, suggest the need to amend the current second line regimen treatments in Guatemala and the importance of viral genotyping in all patients with first-failure to ART.
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- 2013
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