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138 results on '"Meivelu, Moovendhan"'

17. Acrylamide exposure: Dietary risks of oral carcinoma in non-smokers

Author

Gokul Sudhakaran, Kuppusamy Sathishkumar, and Meivelu Moovendhan

Subjects
Acrylamide, Cancer, Diet, Smoking, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Acrylamide, classified as a probable human carcinogen, is primarily found in plant-derived foods like potatoes, grains, and coffee, with heightened formation during high-temperature cooking. Exposure occurs through food and cigarette smoke. Rodent studies indicate an increased cancer risk, with acrylamide converting into glycidamide, causing DNA damage. Its hydrophilic nature allows penetration into various body tissues. Though evidence linking dietary acrylamide intake to head and neck cancer risk is inconclusive, potential exceptions exist. Further research, particularly on non-smokers, is recommended. Minimizing exposure via dietary and cooking modifications is crucial. Additional studies on human acrylamide and oral cancer risk are needed for effective public health strategies.

Published
2024
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35. Anticancer Activity of Rhizophora mucronata Leaves Extract on Sprague–Dawley Rats: In Vivo Model

Author

Asbin Mary X, Syed Ali Mohamed Yacoob, Anuradha Venkatraman, Ruban Packiasamy, Meivelu Moovendhan, Murugesan Gnanadesigan, and Yogananth Nagarajan

Subjects
Toxicology. Poisons, RA1190-1270
Abstract

Medicinal plants are now used to treat cancer due to the presence of bioactive compounds. Apart from the plants, mangroves also possess rich bioactive compounds with high medicinal activity. Based on the ethnobotanical attributes of Rhizophora mucronata, we are keen to work with its anticancer activity. The aim of the study is to assess the anticancer activity of methanolic extract of Rhizophora mucronata leaves against breast cancer. Its safety profile for anticancer investigations was therefore confirmed through an acute toxicity assessment. In accordance with OECD guiding principles, the study was approved to evaluate the toxicity, including acute and subacute effects and anticancer activities of methanolic extract of Rhizophora mucronata leaves on Sprague–Dawley rats. In acute toxicity trials, the dose of 1000 mg/kg body weight was determined to be safe and nontoxic even at high dose levels and did not result in any indicators of toxicity or death in the tested groups compared to controls for 14 days. In contrast, rats in a subacute toxicity study were given consistent doses of 100 mg/kg, 200 mg/kg, and 300 mg/kg for a total of 28 days along with a control group. Haematological, biochemical, and histological tests conducted in advance revealed that methanolic extract of Rhizophora mucronata leaves (MERML) at repeated doses of 200 mg/kg and 300 mg/kg was normal and had no significant effects on the treated groups. Rhizophora mucronata extract (250 mg/kg) was successfully used in in vivo trials to stop the growth of breast cancer cells in groups that had been given DMBA. Based on these findings, it has been concluded that methanolic extract of Rhizophora mucronata leaves (MERML) was safe at both higher and lower dosages and could be assessed for pharmacological study.

Published
2023
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45. Chitosan nanocomposite as an effective carrier of potential herbicidal metabolites for noteworthy phytotoxic effect against major aquatic invasive weed water hyacinth (Eichhornia crassipes)

Author

S Karthick Raja Namasivayam, U Karthika Pandian, Vani Chava, R S Arvind Bharani, M Kavisri, and Meivelu Moovendhan

Subjects
Structural Biology, General Medicine, Molecular Biology, Biochemistry
Abstract

In this current work, the herbicidal activity of fungal metabolites stacked chitosan nanocomposite against significant aquatic invasive weed Eichhornia crassipes (water hyacinth) was examined. Herbicidal metabolites from the fungal strain Allophoma oligotrophica were extracted and purified under standard condition. Altered ionic gelation technique was received for the amalgamation of chitosan nanocomposite fabricated with herbicidal metabolites. Synthesized nanocomposite incited checked herbicidal impact on the leaflets of water hyacinth. Synthesized nanocomposite induced marked herbicidal effect on the tested leaflets of water hyacinth. Necrotic development on the tested leaflets at earlier incubation period followed by progressive enhancement of necrotic lesion reveals the noteworthy herbicidal activity of the synthesized nanocomposite. Parenchymal, mesenchymal tissue disintegration, reduction of total chlorophyll content, elevated anti oxidative enzymes and changes in qualitative protein profiling of tested leaflets reveals the nanocomposite induced noteworthy morphometric and functional effects. Effect of solvents on the release profile demonstrates that ethyl acetate treatment brought about controlled or sustained release of metabolites. No sign of toxic effect on the zebra fish embryonic developmental stages revealed biocompatibility of the nanocomposite.

Published
2023

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