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The agitator is a kind of general equipment that is widely used in industrial and agricultural production. It involves many fields such as petroleum, chemical industry, rubber and coatings. All of which aim at obtaining homogeneous materials, improving the service performance of materials or accelerating the reaction. Compared with the ordinary agitator, the planetary agitator has a wider agitating range. This article introduces the structure and working method of planetary wheel agitator. The mathematical model of the movement track of a point on the mixing shovel is established, an example model of planetary stirring is designed and verified by comparison between Adams software and MATLAB software. On the basis of this, the change law of motion trajectory and coverage rate is analyzed; In addition to this, the influence of speed ratio on speed distribution is analyzed by EDEM simulation, which provides reference for subsequent design improvement.

BACKGROUND Imatinib is the standard treatment for patients with gastrointestinal stromal tumors (GISTs), but there is significant variation in imatinib plasma trough concentrations (Cmin ) among patients. The imatinib Cmin distribution at different doses and the correlation of adverse reactions with Cmin in Chinese patients with GIST from a high-volume center were evaluated. METHODS From July 1, 2017 to December 31, 2018, patients who were receiving imatinib treatment for GIST were prospectively enrolled. Steady-state blood samples were obtained from patients who had received same-dose imatinib treatment for ≥1 month with good compliance. Adverse reactions were recorded during regular follow-up, and blood samples were collected 24 ± 2 hours after dosing. Liquid chromatography-tandem mass spectrometry was used to measure drug concentrations. RESULTS In total, 307 patients who received 367 dose levels were investigated. The imatinib Cmin was 1315 ± 716 ng/mL, 2117 ± 597 ng/mL, and 3844 ± 987 ng/mL in patients who were receiving imatinib 400 mg, 600 mg, and 800 mg daily, respectively. The Cmin was significantly correlated with periorbital and limb edema (P

Purpose: To explore practical experience in home care of nursing interns. Methods: The phenomenological method for qualitative research was to interview 15 nursing interns in a semi-structured way, and then the collected data were analyzed and summarized by using the Colaizzi analysis method. Results: Interviewing results showed that there were five recurring themes, including: 1) personalized care; 2) health education; 3) humanistic care; 4) solid professional foundation and sense of responsibility; 5) expanded vision. Conclusion: Through home care practice, nursing interns deepened their cognitions of nursing connotation, stimulated their love for nursing and motivation of continuous learning, and improved their sense of identity to nursing career. In general, the practice of home care had a positive impact on nursing interns.

Objective: To explore the application of “Internet plus nursing service” program under the pandemic of novel coronavirus pneumonia (NCP). Methods: Nurses of Transitional Care Department of the author’s hospital assessed and categorized adequately the patients who applied for services online and used a combination of online and offline approaches to provide nursing care to patients at home. Results: During the pandemic of novel coronavirus pneumonia from January 19th to March 31st, Transitional Care Department adopted the “Internet plus nursing service” mode to provide nursing services for 357 cases of the in home patients, which was approximately three times the number of the same period in last year. As a result of a comprehensive evaluation, 248 cases of patients’ medical care problems were solved through online educational guidance and consultation; 101 cases of patients were served by home-based services; and 8 cases of patients were recommended to receive professional medical treatment in hospital. There were no patients admitted to the hospital for reasons such as changes in their conditions through follow-up visits, and home visit nurses were in good health. Conclusion: In-home patients have greater demands for the “Internet plus nursing service” due to the pandemic of novel coronavirus pneumonia. Applying the “Internet plus nursing service” mode to serve patients can not only meet the medical needs of in-home patients, but also effectively relieve the pressure of hospital treatment. Moreover, it also reduces the risk of cross-infection by decreasing the number of staffs for mass gatherings, which plays a paramount role in control and prevention of the novel coronavirus pneumonia prevention.

6068 Background: Neoadjuvant treatment with gemcitabine plus cisplatin (GP) prior to concurrent chemoradiotherapy (CCRT) has favorable survival outcomes with acceptable toxicity in patients with locoregionally advanced nasopharyngeal carcinoma (LANPC), 10% of whom achieved complete response (CR) after neoadjuvant treatment. Immune checkpoint blockade therapy plus GP regimen has been shown to improve the survival in recurrent or metastatic NPC. We investigated the efficacy and safety of neoadjuvant treatment with GP plus tislelizumab, an anti-PD-1 monoclonal antibody, in previously untreated LANPC. Methods: In this phase II, single-armed Simon two-stage study, eligible patients are of age 18-70, with adequate haematological, renal, and hepatic function, diagnosed with staged III-IVa（AJCC 8th） non-keratinizing LANPC. Enrolled patients received intravenous gemcitabine (1000 mg/m2) on days 1 and 8, cisplatin (80 mg/m2) on day 1, and tislelizumab (200mg) on day 1 every 3 weeks for 3 cycles followed by standard CCRT. The primary endpoint was CR rate after neoadjuvant treatment, using Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 by investigator. The secondary endpoints included pathology complete response (pCR) rate, 2-year progress-free survival (PFS), overall survival (OS), locoregional failure-free survival (LRRFS), distant metastasis-free survival (DMFS), and toxicity. This study is registered with ClinicalTrials.gov, NCT04833257, all enrolled patients have finished their treatment and the follow-up is ongoing. Results: From April 14th 2021 to August 5th, 2021, a total of 63 patients (median age 46y, 74.6% male) were enrolled at Sun Yat-sen University Cancer Center. As of January 31st, 2022, the median follow-up is 7.37 months, no patients had disease progression. The CR rate after neoadjuvant treatment was 41.3% (95% CI, 28.8% to 53.8%). The ORR and pCR rate were 88.9% (95% CI, 80.9% to 96.9%) and 75.8% (95% CI, 64.8% to 86.8%), respectively. The incidence of acute treatment-related AEs (trAEs) and immune-related adverse events (irAEs) of grade 3 or 4 was 69.8% and 3.2%, respectively. All of irAEs for grade 3 or 4 were hepatotoxicity and skin rash. Long-term efficacy is awaited. Conclusions: Neoadjuvant treatment with GP plus tislelizumab achieved impressive CR rate and pCR rate with manageable toxicities. Further follow-up is needed to confirm the long-term efficacy. Clinical trial information: NCT04833257.

Acquired immune deficiency syndrome, caused by the human immunodeficiency virus (HIV), has been associated with intestinal dysbiosis, which includes an increase in the number of mucosa-associated pathobionts. In the present study, the intestinal mucosal microbiota patterns of HIV-infected patients were compared with those of healthy individuals in a population from Guangzhou, China. The gut microbiota of intestinal mucosal samples from 12 patients with HIV (transmission routes included sex and intravenous drug abuse) was compared with that of 12 healthy age- and sex-matched controls. Gut microbial communities were profiled via sequencing of the bacterial 16S ribosomal RNA genes. Dysbiosis in HIV-infected individuals was characterized by decreased α-diversity, decreased levels of Firmicutes and increased levels of Proteobacteria. Furthermore, low mean counts of Lachnoclostridium, Roseburia, Thauera, Dorea and Roseburia inulinivorans, and high mean counts of Halomonas and Shewanella bacteria, were indicated to be HIV-associated mucosal bacterial alterations. The relative abundance of Fusobacterium and Lachnoclostridium was significantly decreased, while that of Halomonas and Shewanella was significantly increased in patients with sexually transmitted HIV-infection compared with healthy controls. Alterations of the gut microbiota during HIV infection were also indicated to be associated with the route of HIV transmission. Certain bacteria may be potential biomarkers for HIV infection in patients from Guangzhou, China.

Background. No consensus exists regarding which procedures should be performed to disinfect endoscopes and working platforms after COVID-19 patients have undergone endoscopy. Methods. We analyzed the disinfection quality of endoscopes and working platforms after 11 COVID-19 patients had undergone endoscopy. Conclusions. For endoscopic preprocessing at the bedside, a key disinfection step is using a multienzyme stock solution. The nucleic acid tests for endoscopists, washers, endoscopes, and working platforms were all negative. Based on our experience with the 11 COVID-19 patients who had undergone endoscopy, we provide an endoscopic reprocessing method for the bedside endoscopic diagnosis and treatment of COVID-19 patients for reference.

// Gao Yi 1, 2, * , Li Li 3, 4, * , Meijuan Luo 5, * , Xuan He 1 , Zhimin Zou 1 , Zhengtao Gu 3, 4 and Lei Su 1, 6 1 Southern Medical University, Guangzhou, 510515, P.R. China 2 The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, P.R. China 3 Department of Intensive Care Unit, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, P.R. China 4 Department of Pathophysiology, Southern Medical University, Guangdong Provincial Key Laboratory of Shock and Microcirculation Research, Guangzhou 510515, P.R. China 5 Department of Pediatrics, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, 510180, P.R. China 6 Department of Intensive Care Unit, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, 510010, P.R. China * These authors have contributed equally to this work Correspondence to: Zhengtao Gu, email: guzhengtao@126com Lei Su, email: sulei_icu@163.com Keywords: heat stress, cathepsin B, lysosomal membrane permeabilization, mitochondrial, apoptosis Received: September 18, 2016 Accepted: December 08, 2016 Published: March 28, 2017 ABSTRACT Damage to the small intestine secondary to heat stroke is a major factor in heat stroke-related morbidity and mortality. However, the underlying mechanisms by which heat stroke causes small intestinal lesions and dysfunction remain unclear. To explore the pathogenesis of small intestinal tissue and epithelial cell injury, the SW480 cell heat stress model and the mice heat stroke model were established to mimic heat stroke. Morphologic changes in intestinal tissue and increased TUNEL-positive index were induced by heat stress in vivo . Heat stress activated the lysosomal-mitochondrial apoptotic pathway in SW480 cells, increasing intracellular reactive oxygen species and causing lysosomal membrane permeabilization with subsequent release of cathepsin B to the cytosol, mitochondrial depolarization, and cytochrome C release to cytosol. An increase in the Bax/Bcl2 ratio, caspase-9 and caspase-3 were observed. N-Acetyl-L-Cysteine was shown to inhibit ROS generation, suppress permeabilization of lysosomal membranes, decrease levels of cathepsin B and cytochrome C in the cytosol, and inhibit Bax/Bcl2 ratio, caspase-9 and caspase-3 activity both in vitro and in vivo . Mitochondrial damage was alleviated when the models were pre-treated with CA-074 Me both in vitro and in vivo , decreasing cathepsin B and cytochrome C levels in the cytosol, Bax/Bcl2 ratio, caspase-9 and caspase-3 activity. In our models, heat stress-induced apoptosis of small intestinal tissue and epithelial cells through accumulation of ROS and activation of the lysosomal–mitochondrial apoptotic pathway involved the release of cathepsin B. These findings may offer potentially pharmaceutical targets and strategies to repair intestinal injury caused by heat stroke.

In order to elucidate the influence of terroir on wine aroma compounds of Cabernet Sauvignon and Merlot varieties, aroma compounds of two monovarietal wines from the four wine grape-growing regions were investigated for the first time in this research. Aroma compounds of wine were analyzed by solid-phase microextraction with gas chromatography–mass spectrometry (SPME-GC/MS). A total of 58 volatile compounds were identified and quantified in Cabernet Sauvignon and Merlot wines. In the volatiles detected, alcohols formed the most abundant group in the aroma compounds of two monovarietal wines, followed by esters and fatty acids. Cabernet Sauvignon wines from the HBSC region had the highest levels of aroma compounds while Merlot wines had the lowest. According to their odor active values (OAV s ), ethyl octanoate, ethyl hexanoate, isoamyl acetate, ethyl acetate, 2-phenylethanol, 3-(methylthio)-1-propanol, and isoamyl alcohol were the impact odorants of two monovarietal wines, showing only quantitative but not qualitative differences in different regional wines. The shape of the OAV s for the HBSC and the HBCL regional Merlot wines is very similar. According to the data analysis of aroma compounds, the volatile compounds can be affected by “terroir” factor, further, the magnitude of the influence by the “terroir” factor on the aroma of young wine could be in relation to grape variety.

In order to study complex environmental and ecological problems of Poyang Lake it is necessary to integrate or modify various existing models including hydrological, biological, social economic and other models with GIS techniques. This paper firstly discuses the construction of digital watershed platform for Poyang Lake, which is an integrated GIS environment for spatial data pre-processing and post-processing as well as an important foundation of hydro-ecological simulation, and then presents the integrated framework of coupled hydro-ecological modeling for Poyang Lake watershed (CHEMPLW) and its main functional components. CHEMPLW includes three parts: basic geodatabase, watershed data processing tools, and hydro-ecological models, while hydro-ecological models consist of four subsystems which are socio-human subsystem, land use/cover subsystem, watershed environment subsystem and river-lake/biological subsystem. Finally the integration method using ArcObject and Visual Basic is given.