Author: "Mei, Y." - Searchworks@Jio Institute Digital Library Search Results

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4,176 results on '"Mei, Y."'

1. Search for fractionally charged particles with CUORE

Author: CUORE Collaboration, Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Cao, J., Capelli, S., Capelli, C., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Copello, S., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Moore, M. N., Napolitano, T., Nastasi, M., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Oregui, B. T., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Pottebaum, E. G., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Schmidt, B., Sharma, V., Singh, V., Sisti, M., Speller, D., Stark, P., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, A., Torres, J. A., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.
Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: The Cryogenic Underground Observatory for Rare Events (CUORE) is a detector array comprised by 988 5$\;$cm$\times$5$\;$cm$\times$5$\;$cm TeO$_2$ crystals held below 20 mK, primarily searching for neutrinoless double-beta decay in $^{130}$Te. Unprecedented in size amongst cryogenic calorimetric experiments, CUORE provides a promising setting for the study of exotic through-going particles. Using the first tonne-year of CUORE's exposure, we perform a search for hypothesized fractionally charged particles (FCPs), which are well-motivated by various Standard Model extensions and would have suppressed interactions with matter. No excess of FCP candidate tracks is observed over background, setting leading limits on the underground FCP flux with charges between $e/24-e/5$ at 90\% confidence level. Using the low background environment and segmented geometry of CUORE, we establish the sensitivity of tonne-scale sub-Kelvin detectors to diverse signatures of new physics., Comment: 7 pages, 5 figures
Published: 2024

2. Data-driven background model for the CUORE experiment

Author: CUORE Collaboration, Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Cao, J., Capelli, S., Capelli, C., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Moore, M. N., Napolitano, T., Nastasi, M., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Oregui, B. T., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Ponce, I., Pottebaum, E. G., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Schmidt, B., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A, Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.
Subjects: Nuclear Experiment, Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract: We present the model we developed to reconstruct the CUORE radioactive background based on the analysis of an experimental exposure of 1038.4 kg yr. The data reconstruction relies on a simultaneous Bayesian fit applied to energy spectra over a broad energy range. The high granularity of the CUORE detector, together with the large exposure and extended stable operations, allow for an in-depth exploration of both spatial and time dependence of backgrounds. We achieve high sensitivity to both bulk and surface activities of the materials of the setup, detecting levels as low as 10 nBq kg$^{-1}$ and 0.1 nBq cm$^{-2}$, respectively. We compare the contamination levels we extract from the background model with prior radio-assay data, which informs future background risk mitigation strategies. The results of this background model play a crucial role in constructing the background budget for the CUPID experiment as it will exploit the same CUORE infrastructure.
Published: 2024

3. With or without $\nu$? Hunting for the seed of the matter-antimatter asymmetry

Author: CUORE Collaboration, Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Cao, J., Capelli, S., Capelli, C., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Moore, M. N., Napolitano, T., Nastasi, M., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Oregui, B. T., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Ponce, I., Pottebaum, E. G., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Schmidt, B., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A, Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.
Subjects: Nuclear Experiment
Abstract: The matter-antimatter asymmetry underlines the incompleteness of the current understanding of particle physics. Neutrinoless double-beta ($0\nu \beta\beta$) decay may help explain this asymmetry, while unveiling the Majorana nature of the neutrino. The CUORE experiment searches for $0\nu \beta\beta$ decay of $^{130}$Te using a tonne-scale cryogenic calorimeter operated at milli-kelvin temperatures. We report no evidence for $0\nu \beta\beta$ decay and place a lower limit on the half-life of T$_{1/2}$ $>$ 3.8 $\times$ 10$^{25}$ years (90% C.I.) with over 2 tonne$\cdot$year TeO$_2$ exposure. The tools and techniques developed for this result and the 5 year stable operation of nearly 1000 detectors demonstrate the infrastructure for a next-generation experiment capable of searching for $0\nu \beta\beta$ decay across multiple isotopes.
Published: 2024

4. First operation of a multi-channel Q-Pix prototype: measuring transverse electron diffusion in a gas time projection chamber

Author: Hoch, N, Seidel, O, Chirayath, VA, Enriquez, AB, Gramellini, E, Guenette, R, Jaidee, IW, Keefe, K, Kohani, S, Kubota, S, Mahdy, H, McDonald, AD, Mei, Y, Miao, P, Newcomer, FM, Nygren, D, Parmaksiz, I, Rooks, M, Tzoka, I, Wei, W-Z, Asaadi, J, and Battat, JBR
Subjects: Nuclear and Plasma Physics, Synchrotrons and Accelerators, Physical Sciences, Bioengineering, Engineering, Nuclear & Particles Physics, Physical sciences
Abstract: Abstract: We report measurements of the transverse diffusion of electrons in P-10 gas (90% Ar, 10% CH4) in a laboratory-scale time projection chamber (TPC) utilizing a novel pixelated signal capture and digitization technique known as Q-Pix. The Q-Pix method incorporates a precision switched integrating transimpedance amplifier whose output is compared to a threshold voltage. Upon reaching the threshold, a comparator sends a 'reset' signal, initiating a discharge of the integrating capacitor. The time difference between successive resets is inversely proportional to the average current at the pixel in that time interval, and the number of resets is directly proportional to the total collected charge. We developed a 16-channel Q-Pix prototype fabricated from commercial off-the-shelf components and coupled them to 16 concentric annular anode electrodes to measure the spatial extent of the electron swarm that reaches the anode after drifting through the uniform field of the TPC. The swarm is produced at a gold photocathode using pulsed UV light. The measured transverse diffusion agrees with simulations in PyBoltz across a range of operating pressures (200–1500 Torr). These results demonstrate that a Q-Pix readout can successfully reconstruct the ionization topology in a TPC.
Published: 2024

5. Analysis of the microbial diverisity and the mechanism of simultaneous nitrification and denitrification in high nitrogen environments

Author: Zhang, X. Y., Zeng, Y. W., Tao, R. D., Zhang, M., Zheng, M. M., Qu, M. J., and Mei, Y. J.
Published: 2024
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6. Erratum: Measurement of the 2νββ Decay Half-Life of Te130 with CUORE [Phys. Rev. Lett. 126, 171801 (2021)]

Author: Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Chiesa, D, Clemenza, M, Copello, S, Cosmelli, C, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Davis, CJ, Dell’Oro, S, Di Domizio, S, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Ligi, C, Ma, L, G., Y, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moggi, N, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O’Donnell, T, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Rosenfeld, C, Rusconi, C, Sakai, M, Sangiorgio, S, Schmidt, B, Scielzo, ND, Sharma, V, Singh, V, Sisti, M, Speller, D, Surukuchi, PT, and Taffarello, L
Subjects: Nuclear and Plasma Physics, Physical Sciences, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract: This corrects the article DOI: 10.1103/PhysRevLett.126.171801.
Published: 2023

7. NvDEx-100 Conceptual Design Report

Author: Cao, X., Chang, Y., Chen, K., Ciuffoli, E., Duan, L., Fang, D., Gao, C., Ghorui, S. K., Hu, P., Hu, Q., Huang, S., Huang, Z., Lang, L., Li, Y., Li, Z., Liang, T., Liu, J., Lu, C., Mai, F., Mei, Y., Qiu, H., Sun, X., Tang, X., Wang, H., Wang, Q., Xiao, L., Xiao, M., Xin, J., Xu, N., Yang, P., Yang, Y., Yang, Z., Yu, Z., Zhang, D., Zhang, J., Zhao, C., and Zhu, D.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Observing nuclear neutrinoless double beta (0vbb) decay would be a revolutionary result in particle physics. Observing such a decay would prove that the neutrinos are their own antiparticles, help to study the absolute mass of neutrinos, explore the origin of their mass, and may explain the matter-antimatter asymmetry in our universe by lepton number violation. We propose developing a time projection chamber (TPC) using high-pressure 82SeF6 gas and top-metal silicon sensors for read-out in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of 82Se, called the NvDEx experiment. Besides being located at CJPL with the world's thickest rock shielding, NvDEx combines the advantages of the high Qbb (2.996 MeV) of 82Se and the TPC's ability to distinguish signal and background events using their different topological characteristics. This makes NvDEx unique, with great potential for low-background and high-sensitivity 0vbb searches. NvDEx-100, a NvDEx experiment phase with 100 kg of SeF6 gas, is being built, with plans to complete installation at CJPL by 2025. This report introduces 0vbb physics, the NvDEx concept and its advantages, and the schematic design of NvDEx-100, its subsystems, and background and sensitivity estimation.
Published: 2023
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8. A first test of CUPID prototypal light detectors with NTD-Ge sensors in a pulse-tube cryostat

Author: CUPID collaboration, Alfonso, K., Armatol, A., Augier, C., Avignone III, F. T., Azzolini, O., Balata, M., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Berest, V., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Campani, A., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dabagov, S., Dafinei, I., Danevich, F. A., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompé, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Lefevre, M., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mas, Ph., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J. A., Schmidt, B., Sharma, V., Shlegel, V. N., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: CUPID is a next-generation bolometric experiment aiming at searching for neutrinoless double-beta decay with ~250 kg of isotopic mass of $^{100}$Mo. It will operate at $\sim$10 mK in a cryostat currently hosting a similar-scale bolometric array for the CUORE experiment at the Gran Sasso National Laboratory (Italy). CUPID will be based on large-volume scintillating bolometers consisting of $^{100}$Mo-enriched Li$_2$MoO$_4$ crystals, facing thin Ge-wafer-based bolometric light detectors. In the CUPID design, the detector structure is novel and needs to be validated. In particular, the CUORE cryostat presents a high level of mechanical vibrations due to the use of pulse tubes and the effect of vibrations on the detector performance must be investigated. In this paper we report the first test of the CUPID-design bolometric light detectors with NTD-Ge sensors in a dilution refrigerator equipped with a pulse tube in an above-ground lab. Light detectors are characterized in terms of sensitivity, energy resolution, pulse time constants, and noise power spectrum. Despite the challenging noisy environment due to pulse-tube-induced vibrations, we demonstrate that all the four tested light detectors comply with the CUPID goal in terms of intrinsic energy resolution of 100 eV RMS baseline noise. Indeed, we have measured 70--90 eV RMS for the four devices, which show an excellent reproducibility. We have also obtained outstanding energy resolutions at the 356 keV line from a $^{133}$Ba source with one light detector achieving 0.71(5) keV FWHM, which is -- to our knowledge -- the best ever obtained when compared to $\gamma$ detectors of any technology in this energy range., Comment: Prepared for submission to JINST; 16 pages, 7 figures, and 1 table
Published: 2023
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9. Twelve-crystal prototype of Li$_2$MoO$_4$ scintillating bolometers for CUPID and CROSS experiments

Author: CUPID, collaborations, CROSS, Alfonso, K., Armatol, A., Augier, C., Avignone III, F. T., Azzolini, O., Balata, M., Bandac, I. C., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Berest, V., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Calvo-Mozota, J. M., Camilleri, J., Campani, A., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dabagov, S., Dafinei, I., Danevich, F. A., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompé, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Girola, M., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Ianni, A., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Lefevre, M., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marrache-Kikuchi, C. A., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mas, Ph., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J. A., Schmidt, B., Sharma, V., Shlegel, V. N., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J. A., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: An array of twelve 0.28 kg lithium molybdate (LMO) low-temperature bolometers equipped with 16 bolometric Ge light detectors, aiming at optimization of detector structure for CROSS and CUPID double-beta decay experiments, was constructed and tested in a low-background pulse-tube-based cryostat at the Canfranc underground laboratory in Spain. Performance of the scintillating bolometers was studied depending on the size of phonon NTD-Ge sensors glued to both LMO and Ge absorbers, shape of the Ge light detectors (circular vs. square, from two suppliers), in different light collection conditions (with and without reflector, with aluminum coated LMO crystal surface). The scintillating bolometer array was operated over 8 months in the low-background conditions that allowed to probe a very low, $\mu$Bq/kg, level of the LMO crystals radioactive contamination by $^{228}$Th and $^{226}$Ra., Comment: Prepared for submission to JINST; 23 pages, 9 figures, and 4 tables
Published: 2023
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10. Consequence severity-probability importance measure for fault tree analysis

Author: Lau, Mei Y., Liu, Yunmei, and Kaber, David B.
Published: 2024
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11. Percutaneous Transforaminal Endoscopic Discectomy for Adjacent Segment Disease versus Lumbar Disc Herniation in Elderly Patients

Author: Yuan S, Lu X, Zang L, Mei Y, Fan N, and Du P
Subjects: adjacent segment degeneration, percutaneous transforaminal endoscopic discectomy, clinical outcomes, geriatric patients, minimally invasive, Medicine (General), R5-920
Abstract: Shuo Yuan,&ast; Xuanyu Lu,&ast; Lei Zang, Yuqi Mei, Ning Fan, Peng Du Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100043, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lei Zang, Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, 5 JingYuan Road, Shijingshan District, Beijing, 100043, People’s Republic of China, Email zanglei@ccmu.edu.cnPurpose: Percutaneous transforaminal endoscopic discectomy (PTED) was used as a minimally invasive treatment option for lumbar disc herniation (LDH). However, studies focusing on the clinical outcomes of PTED for elderly patients with adjacent segment disease (ASD) were limited. This study aims to compare the clinical outcomes of PTED between ASD and LDH in elderly patients.Patients and Methods: This retrospective study enrolled 39 patients with ASD and 39 patients with LDH. Both groups had undergone PTED in Beijing Chaoyang Hospital from July 4, 2016 to July 30, 2021. Visual analog scale for back pain (VAS-BP) and leg pain (VAS-LP) and Oswestry disability index (ODI) were used to value the clinical outcomes of patients preoperatively, immediately postoperatively, 12, and 24 months postoperatively, and at final follow-up. Patients’ satisfaction was evaluated based on the MacNab criteria.Results: All operations were completed. The excellent or good clinical outcomes at final follow-up was demonstrated by 87.15% (34/39) and 89.74% (35/39) in ASD and non-ASD patients, respectively. Clinical improvement was observed immediately postoperatively in both groups and sustained stability during the postoperative follow-up. The ASD group demonstrated significantly longer hospital stays (p = 0.02) and operative time (p < 0.01) than the non-ASD group.Conclusion: PTED is an effective and minimally invasive treatment option for revision surgery of ASD, especially for elderly patients. However, the long-term prognosis of PTED treating ASD still needs further exploration.Keywords: adjacent segment degeneration, percutaneous transforaminal endoscopic discectomy, clinical outcomes, geriatric patients, minimally invasive
Published: 2024

12. Neutrinoless Double Beta Decay

Author: Adams, C., Alfonso, K., Andreoiu, C., Angelico, E., Arnquist, I. J., Asaadi, J. A. A., Avignone, F. T., Axani, S. N., Barabash, A. S., Barbeau, P. S., Baudis, L., Bellini, F., Beretta, M., Bhatta, T., Biancacci, V., Biassoni, M., Bossio, E., Breur, P. A., Brodsky, J. P., Brofferio, C., Brown, E., Brugnera, R., Brunner, T., Burlac, N., Caden, E., Calgaro, S., Cao, G. F., Cao, L., Capelli, C., Cardani, L., Fernandez, R. Castillo, Cattadori, C. M., Chana, B., Chernyak, D., Christofferson, C. D., Chu, P. -H., Church, E., Cirigliano, V., Collister, R., Comellato, T., Dalmasson, J., D'Andrea, V., Daniels, T., Darroch, L., Decowski, M. P., Demarteau, M., Peixoto, S. De Meireles, Detwiler, J. A., DeVoe, R. G., Di Domizio, S., Di Marco, N., di Vacri, M. L., Dolinski, M. J., Efremenko, Yu., Elbeltagi, M., Elliott, S. R., Engel, J., Fabris, L., Fairbank, W. M., Farine, J., Febbraro, M., Figueroa-Feliciano, E., Fields, D. E., Formaggio, J. A., Foust, B. T., Franke, B., Fu, Y., Fujikawa, B. K., Gallacher, D., Gallina, G., Garfagnini, A., Gingras, C., Gironi, L., Giuliani, A., Gold, M., Gornea, R., Grant, C., Gratta, G., Green, M. P., Grinyer, G. F., Gruszko, J., Guan, Y., Guinn, I. S., Guiseppe, V. E., Gutierrez, T. D., Hansen, E. V., Hardy, C. A., Hauptman, J., Heffner, M., Heeger, K. M., Henning, R., Hergert, H., Aguilar, D. Hervas, Hodak, R., Holt, J. D., Hoppe, E. W., Horoi, M., Huang, H. Z., Inoue, K., Jamil, A., Jochum, J., Jones, B. J. P., Kaizer, J., Karapetrov, G., Kharusi, S. Al, Kidd, M. F., Kishimoto, Y., Klein, J. R., Kolomensky, Yu. G., Kontul, I., Kornoukhov, V. N., Krause, P., Krucken, R., Kumar, K. S., Lang, K., Leach, K. G., Lenardo, B. G., Leonhardt, A., Li, A., Li, G., Li, Z., Licciardi, C., Lindsay, R., Lippi, I., Liu, J., Macko, M., MacLellan, R., Macolino, C., Majidi, S., Mamedov, F., Masbou, J., Massarczyk, R., Mastbaum, A. T., Mayer, D., Mazumdar, A., Mei, D. M., Mei, Y., Meijer, S. J., Mereghetti, E., Mertens, S., Mistry, K., Mitsui, T., Moore, D. C., Morella, M., Nattress, J. T., Neuberger, M., Ngwadla, X. E., Nones, C., Novosad, V., Nygren, D. R., Ondze, J. C. Nzobadila, O'Donnell, T., Gann, G. D. Orebi, Orrell, J. L., Ortega, G. S., Ouellet, J. L., Overman, C., Pagani, L., Palusova, V., Para, A., Pavan, M., Perna, A., Pertoldi, L., Pettus, W., Piepke, A., Piseri, P., Pocar, A., Povinec, P., Psihas, F., Pullia, A., Radford, D. C., Ramonnye, G. J, Rasiwala, H., Redchuk, M., Riboldi, S., Richardson, G., Rielage, K., Rogers, L., Rowson, P. C., Rukhadze, E., Saakyan, R., Sada, C., Salamanna, G., Salamida, F., Saldanha, R., Salvat, D. J., Sangiorgio, S., Schaper, D. C., Schoenert, S., Schwarz, M., Schwartz, S. E., Shitov, Y., Simkovic, F., Singh, V., Slavickova, M., Sousa, A. C., Spadoni, F. L., Speller, D. H., Stekl, I., Sumathi, R. R., Surukuchi, P. T., Tayloe, R., Tornow, W., Torres, J. A., Totev, T. I., Triambak, S., Tyuka, O. A., Vasilyev, S. I., Velazquez, M., Viel, S., Vogl, C., von Strum, K., Wang, Q., Waters, D., Watkins, S. L., Watts, M., Wei, W. -Z., Welliver, B., Wen, Liangjian, Wichoski, U., Wilde, S., Wilkerson, J. F., Winslow, L., Wiseman, C., Wu, X., Xu, W., Yang, H., Yang, L., Yu, C. H., Zeman, J., Zennamo, J., and Zuzel, G.
Subjects: Nuclear Experiment, Nuclear Theory
Abstract: This White Paper, prepared for the Fundamental Symmetries, Neutrons, and Neutrinos Town Meeting related to the 2023 Nuclear Physics Long Range Plan, makes the case for double beta decay as a critical component of the future nuclear physics program. The major experimental collaborations and many theorists have endorsed this white paper., Comment: white paper submitted for the Fundamental Symmetries, Neutrons, and Neutrinos Town Meeting in support of the US Nuclear Physics Long Range Planning Process
Published: 2022

13. ATHENA Detector Proposal -- A Totally Hermetic Electron Nucleus Apparatus proposed for IP6 at the Electron-Ion Collider

Author: ATHENA Collaboration, Adam, J., Adamczyk, L., Agrawal, N., Aidala, C., Akers, W., Alekseev, M., Allen, M. M., Ameli, F., Angerami, A., Antonioli, P., Apadula, N. J., Aprahamian, A., Armstrong, W., Arratia, M., Arrington, J. R., Asaturyan, A., Aschenauer, E. C., Augsten, K., Aune, S., Bailey, K., Baldanza, C., Bansal, M., Barbosa, F., Barion, L., Barish, K., Battaglieri, M., Bazilevsky, A., Behera, N. K., Berdnikov, V., Bernauer, J., Berriaud, C., Bhasin, A., Bhattacharya, D. S., Bielcik, J., Bielcikova, J., Bissolotti, C., Boeglin, W., Bondì, M., Borri, M., Bossu, F., Bouyjou, F., Brandenburg, J. D., Bressan, A., Brooks, M., Bueltmann, S. L., Byer, D., Caines, H., Sanchez, M. Calderon de la Barca, Calvelli, V., Camsonne, A., Cappelli, L., Capua, M., Castro, M., Cavazza, D., Cebra, D., Celentano, A., Chakaberia, I., Chan, B., Chang, W., Chartier, M., Chatterjee, C., Chen, D., Chen, J., Chen, K., Chen, Z., Chetri, H., Chiarusi, T., Chiosso, M., Chu, X., Chwastowski, J. J., Cicala, G., Cisbani, E., Cline, E., Cloet, I., Colella, D., Contalbrigo, M., Contin, G., Corliss, R., Corrales-Morales, Y., Crafts, J., Crawford, C., Cruz-Torres, R., D'Ago, D., D'Angelo, A., D'Hose, N., Dainton, J., Torre, S. Dalla, Dasgupta, S. S., Dash, S., Dashyan, N., Datta, J., Daugherity, M., De Vita, R., Deconinck, W., Defurne, M., Dehmelt, K., Del Dotto, A., Delcarro, F., Dellacasa, G., Demiroglu, Z. S., Deptuch, G. W., Desai, V., Deshpande, A., Devereaux, K., Dhillon, R., Di Salvo, R., Dilks, C., Dixit, D., Dobbs, S., Dong, X., Drachenberg, J., Drees, A., Dupre, R., Durham, M., Dzhygadlo, R., Fassi, L. El, Elia, D., Epple, E., Esha, R., Evdokimov, O., Eyser, O., Falchieri, D., Fan, W., Fantini, A., Fatemi, R., Fazio, S., Fegan, S., Filippi, A., Fox, H., Francisco, A., Freeze, A., Furletov, S., Furletova, Y., Gal, C., Gardner, S., Garg, P., Gaskell, D., Gates, K., Gericke, M. T. W., Geurts, F., Ghosh, C., Giacalone, M., Giacomini, F., Gilchrist, S., Glazier, D., Gnanvo, K., Gonella, L., Greiner, L. C., Guerrini, N., Guo, L., Gupta, A., Gupta, R., Guryn, W., He, X., Hemmick, T., Heppelmann, S., Higinbotham, D., Hoballah, M., Hoghmrtsyan, A., Hohlmann, M., Horn, T., Hornidge, D., Huang, H. Z., Hyde, C. E., Iapozzuto, P., Idzik, M., Jacak, B. V., Jadhav, M., Jain, S., Jena, C., Jentsch, A., Ji, Y., Ji, Z., Jia, J., Jones, P. G., Jones, R. W. I., Joosten, S., Joshi, S., Kabir, L., Kalicy, G., Karyan, G., Kashyap, V. K. S., Kawall, D., Ke, H., Kelsey, M., Kim, J., Kiryluk, J., Kiselev, A., Klein, S. R., Klest, H., Kochar, V., Korsch, W., Kosarzewski, L., Kotzinian, A., Krizek, F., Kumar, A., Kumar, K. S., Kumar, L., Kumar, R., Kumar, S., Kunnath, A., Kushawaha, N., Lacey, R., Lai, Y. S., Lalwani, K., Landgraf, J., Lanza, L., Lattuada, D., Lavinsky, M., Lee, J. H., Lee, S. H., Lemmon, R., Lestone, A., Lewis, N., Li, H., Li, S., Li, W., Li, X., Liang, X., Ligonzo, T., Lin, T., Liu, J., Liu, K., Liu, M., Livingston, K., Liyanage, N., Ljubicic, T., Long, O., Lukow, N., Ma, Y., Mammei, J., Mammoliti, F., Mamo, K., Mandjavidze, I., Maple, S., Marchand, D., Margotti, A., Markert, C., Markowitz, P., Marshall, T., Martin, A., Marukyan, H., Mastroserio, A., Mathew, S., Mayilyan, S., Mayri, C., McEneaney, M., Mei, Y., Meng, L., Meot, F., Metcalfe, J., Meziani, Z. -E., Mihir, P., Milton, R., Mirabella, A., Mirazita, M., Mkrtchyan, A., Mkrtchyan, H., Mohanty, B., Mondal, M., Morreale, A., Movsisyan, A., Muenstermann, D., Mukherjee, A., Camacho, C. Munoz, Murray, M. J., Mustafa, H., Myska, M., Nachman, B. P., Nagai, K., Naik, R., Naim, J. P., Nam, J., Nandi, B., Nappi, E., Nasim, Md., Neff, D., Neiret, D., Newman, P. R., Nguyen, M., Niccolai, S., Nie, M., Noferini, F., Norman, J., Noto, F., Nunes, A. S., O'Connor, T., Odyniec, G., Okorokov, V. A., Osipenko, M., Page, B., Palatchi, C., Palmer, D., Palni, P., Pandey, S., Panzieri, D., Park, S., Paschke, K., Pastore, C., Patra, R. N., Paul, A., Paul, S., Pecar, C., Peck, A., Pegg, I., Pellegrino, C., Peng, C., Pentchev, L., Perrino, R., Piotrzkowski, K., Polakovic, T., Ploskon, M., Posik, M., Prasad, S., Preghenella, R., Priens, S., Prifti, E., Przybycien, M., Pujahari, P., Quintero, A., Radici, M., Radhakrishnan, S. K., Rahman, S., Rathi, S., Raue, B., Reed, R., Reimer, P., Reinhold, J., Renner, E., Rignanese, L., Ripani, M., Rizzo, A., Romanov, D., Roy, A., Rubini, N., Ruspa, M., Ruan, L., Sabatie, F., Sadhukhan, S., Sahoo, N., Sahu, P., Samuel, D., Sarkar, A., Sarsour, M., Schmidke, W., Schmookler, B., Schwarz, C., Schwiening, J., Scott, M., Sedgwick, I., Segreti, M., Sekula, S., Seto, R., Shah, N., Shahinyan, A., Sharma, D., Sharma, N., Sichtermann, E. P., Signori, A., Singh, A., Singh, B. K., Singh, S. N., Smirnov, N., Sokhan, D., Soltz, R., Sondheim, W., Spinali, S., Stacchi, F., Staszewski, R., Stepanov, P., Strazzi, S., Stroe, I. R., Sun, X., Surrow, B., Sweger, Z., Symons, T. J., Tadevosyan, V., Tang, A., Tassi, E., Teodorescu, L., Tessarotto, F., Thomas, D., Thomas, J. H., Toll, T., Tomasek, L., Torales-Acosta, F., Tribedy, P., Triloki, Tripathi, V., Trotta, R., Trzebiński, M., Trzeciak, B. A., Tsai, O., Tu, Z., Turrisi, R., Tuve, C., Ullrich, T., Urciuoli, G. M., Valentini, A., Vallarino, S., Vandenbroucke, M., Vanek, J., Vino, G., Volpe, G., Voskanyan, H., Vossen, A., Voutier, E., Wang, G., Wang, Y., Watts, D., Wickramaarachchi, N., Wilson, F., Wong, C. -P., Wu, X., Wu, Y., Xie, J., Xu, Q. -H., Xu, Z., Xu, Z. W., Yang, C., Yang, Q., Yang, Y., Ye, Z., Yi, L., Yin, Z., Yurov, M., Zachariou, N., Zhang, J., Zhang, Y., Zhang, Z., Zhao, Y., Zhao, Y. X., Zhao, Z., Zheng, L., and Zurek, M.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract: ATHENA has been designed as a general purpose detector capable of delivering the full scientific scope of the Electron-Ion Collider. Careful technology choices provide fine tracking and momentum resolution, high performance electromagnetic and hadronic calorimetry, hadron identification over a wide kinematic range, and near-complete hermeticity. This article describes the detector design and its expected performance in the most relevant physics channels. It includes an evaluation of detector technology choices, the technical challenges to realizing the detector and the R&D required to meet those challenges.
Published: 2022

14. Status and prospects of discovery of 0??? decay with the CUORE detector

Author: Adams, DQ, Alduino, C, Alfonso, K, Avignone, FTIII, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Capelli, C, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D'Addabbo, A, Dafinei, I, Del Corso, F, Dell'Oro, S, Di Domizio, S, Di Lorenzo, S, Dompe, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gianvecchio, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Kowalski, R, Ligi, C, Liu, R, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O'Donnell, T, Olmi, M, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Ponce, I, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, and Rosenfeld, C
Subjects: Astronomy & Astrophysics, Geophysics, Particle and high energy physics
Abstract: In this contribution we present the achievements of the CUORE experiment so far. It is the first tonne-scale bolometric detector and it is in stable data taking since 2018. We reached to collect about 1800 kg×yr of exposure of which more than 1 ton×year have been analysed. The CUORE detector is meant to search for the neutrinoless double β decay (0νββ) of the 130Te isotope. This is a beyond Standard Model process which could establish the nature of the neutrino to be Dirac or a Majorana particle. It is an alternative mode of the two-neutrinos double β decay, a rare decay which have been precisely measured by CUORE in the 130Te. We found no evidence of the 0νββ and we set a Bayesian lower limit of 2.2 ×1025yr on its half-life. The expertise achieved by CUORE set a milestone for any future bolometric detector, including CUPID, which is the planned next generation experiment searching for 0νββ with scintillating bolometers.
Published: 2023

15. Solid State Detectors and Tracking for Snowmass

Author: Affolder, A., Apresyan, A., Worm, S., Albrow, M., Ally, D., Ambrose, D., Anderssen, E., Apadula, N., Asenov, P., Armstrong, W., Artuso, M., Barbier, A., Barletta, P., Bauerdick, L., Berry, D., Bomben, M., Boscardin, M., Brau, J., Brooks, W., Breidenbach, M., Buckley, J., Cairo, V., Caputo, R., Carpenter, L., Centis-Vignali, M., Cerullo, M., Collu, A., Chlebana, F., Dalla-Betta, G. -F., Demarteau, M., Deptuch, G., Di Petrillo, K., D'Amen, G., Dragone, A., Fourches, N. T., Garcia-Sciveres, M., Giacomini, G., Gingu, C., Graf, N., Grace, C., Griso, S., Greiner, L., Haber, C., Haller, G., Harris, K., Heim, T., Heinz, U., Heller, R., Hedges, M. T., Herbst, R., Hoeferkamp, M. R., Holmes, T., Holland, S. E., Hsu, S. -C., Islam, R., Jadhav, M., Jindariani, S., Joosten, S., Jung, A., Karmarkar, S., Kenney, C., Kierans, C., Kim, J., Kim, S., Klein, S., Koshy, A., Krizka, K., Lai, A., Lee, L., Linssen, L., Lipton, R., Liu, T., Madrid, C., Mahajan, T., Markiewicz, T., Markovic, B., Mazza, S., Mazziotta, M., Mei, Y., Merkel, P., Metcalfe, J., Meziani, Z. -E., Minns, A., Moscatelli, F., Murat, P., Muth, J., Nachman, B., Nahn, S., Narain, M., Narayanan, E. A., Nelson, T., Nielsen, J., Oktyabrsky, S., Ott, J., Palomo, F. R., Passeri, D., Patti, R., Peltola, T., Pena, C., Peng, C., Renard, C., Reimer, P., Rogan, C., Rota, L., Sadrozinski, H., Segal, J., Schwartzman, A., Schumm, B., Scott, M., Seidel, S., Seiden, A., Sekely, B., Shi, X., Sichtermann, E., Sinev, N., Sonneveld, J., Spiegel, L., Steinhebel, A., Strom, D., Sultan, D. M. S., Sumant, A., Tokranov, V., Tricoli, A., Trischuk, W., Tumasyan, A., Uplegger, L., Vernieri, C., Wang, H., Wagenknecht, P., Weber, H., Xie, S., Yakimov, M., Ye, Z., Young, C., and Zurek, M.
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract: Tracking detectors are of vital importance for collider-based high energy physics (HEP) experiments. The primary purpose of tracking detectors is the precise reconstruction of charged particle trajectories and the reconstruction of secondary vertices. The performance requirements from the community posed by the future collider experiments require an evolution of tracking systems, necessitating the development of new techniques, materials and technologies in order to fully exploit their physics potential. In this article we summarize the discussions and conclusions of the 2022 Snowmass Instrumentation Frontier subgroup on Solid State and Tracking Detectors (Snowmass IF03)., Comment: for the Snowmass Instrumentation Frontier Solid State Detector and Tracking community
Published: 2022

16. The Dual Angiogenesis Effects via Nrf2/HO-1 Signaling Pathway of Melatonin Nanocomposite Scaffold on Promoting Diabetic Bone Defect Repair

Author: Chen T, Wu Z, Hou Q, Mei Y, Yang K, Xu J, and Wang L
Subjects: diabetic bone defect, melatonin, nrf2/ho-1 signaling pathway, dual angiogenesis effects, 3d printing, Medicine (General), R5-920
Abstract: Tingting Chen,1 Zimei Wu,1,2 Qiaodan Hou,1 Yixin Mei,1 Kunkun Yang,1 Jing Xu,3 Lin Wang1,3 1School of Medicine, Southern University of Science and Technology, Shenzhen, People’s Republic of China; 2Department of Orthopedic Surgery, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, People’s Republic of China; 3Southern University of Science and Technology Hospital, Shenzhen, People’s Republic of ChinaCorrespondence: Lin Wang, Email wangl7@sustech.edu.cnPurpose: Given the escalating prevalence of diabetes, the demand for specific bone graft materials is increasing, owing to the greater tendency towards bone defects and more difficult defect repair resulting from diabetic bone disease (DBD). Melatonin (MT), which is known for its potent antioxidant properties, has been shown to stimulate both osteogenesis and angiogenesis.Methods: MT was formulated into MT@PLGA nanoparticles (NPs), mixed with sodium alginate (SA) hydrogel, and contained within a 3D printing polycaprolactone/β-Tricalcium phosphate (PCL/β-TCP) scaffold. The osteogenic capacity of the MT nanocomposite scaffold under diabetic conditions was demonstrated via in vitro and in vivo studies and the underlying mechanisms were investigated.Results: Physicochemical characterization experiments confirmed the successful fabrication of the MT nanocomposite scaffold, which can achieve long-lasting sustained release of MT. The in vitro and in vivo studies demonstrated that the MT nanocomposite scaffold exhibited enhanced osteogenic capacity, which was elucidated by the dual angiogenesis effects activated through the NF-E2–related factor 2/Heme oxygenase 1 (Nrf2/HO-1) signaling pathway, including the enhancement of antioxidant enzyme activity to reduce the oxidative stress damage of vascular endothelial cells (VECs) and directly stimulating vascular endothelial growth factor (VEGF) production, which reversed the angiogenesis-osteogenesis uncoupling and promoted osteogenesis under diabetic conditions.Conclusion: This study demonstrated the research prospective and clinical implications of the MT nanocomposite scaffold as a novel bone graft for treating bone defect and enhancing bone fusion in diabetic individuals. Keywords: diabetic bone defect, melatonin, Nrf2/HO-1 signaling pathway, dual angiogenesis effects, 3D printing
Published: 2024

17. An Energy-dependent Electro-thermal Response Model of CUORE Cryogenic Calorimeter

Author: CUORE Collaboration, Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Canonica, L., Cao, X. G., Capelli, S., Capelli, C., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Copello, S., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Huang, R. G., Huang, H. Z., Johnston, J., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Li, M., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Sangiorgio, S., Schmidt, B., Scielzo, N. D., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Terranova, F., Tomei, C., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Wang, B. S., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: The Cryogenic Underground Observatory for Rare Events (CUORE) is the most sensitive experiment searching for neutrinoless double-beta decay ($0\nu\beta\beta$) in $^{130}\text{Te}$. CUORE uses a cryogenic array of 988 TeO$_2$ calorimeters operated at $\sim$10 mK with a total mass of 741 kg. To further increase the sensitivity, the detector response must be well understood. Here, we present a non-linear thermal model for the CUORE experiment on a detector-by-detector basis. We have examined both equilibrium and dynamic electro-thermal models of detectors by numerically fitting non-linear differential equations to the detector data of a subset of CUORE channels which are well characterized and representative of all channels. We demonstrate that the hot-electron effect and electric-field dependence of resistance in NTD-Ge thermistors alone are inadequate to describe our detectors' energy dependent pulse shapes. We introduce an empirical second-order correction factor in the exponential temperature dependence of the thermistor, which produces excellent agreement with energy-dependent pulse shape data up to 6 MeV. We also present a noise analysis using the fitted thermal parameters and show that the intrinsic thermal noise is negligible compared to the observed noise for our detectors., Comment: 34 pages, 14 figures, 6 tables
Published: 2022

18. New direct limit on neutrinoless double beta decay half-life of $^{128}$Te with CUORE

Author: Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Canonica, L., Cao, X. G., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Copello, S., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Huang, R. G., Huang, H. Z., Johnston, J., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Ligi, C., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Sangiorgio, S., Schmidt, B., Scielzo, N. D., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Terranova, F., Tomei, C., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Wang, B. S., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.
Subjects: Nuclear Experiment
Abstract: The Cryogenic Underground Observatory for Rare Events (CUORE) at Laboratori Nazionali del Gran Sasso of INFN in Italy is an experiment searching for neutrinoless double beta (0$\nu\beta\beta$) decay. Its main goal is to investigate this decay in $^{130}$Te, but its ton-scale mass and low background make CUORE sensitive to other rare processes as well. In this work, we present our first results on the search for \nbb decay of $^{128}$Te, the Te isotope with the second highest natural isotopic abundance. We find no evidence for this decay, and using a Bayesian analysis we set a lower limit on the $^{128}$Te \nbb decay half-life of T$_{1/2} > 3.6 \times 10^{24}$ yr (90\% CI). This represents the most stringent limit on the half-life of this isotope, improving by over a factor 30 the previous direct search results, and exceeding those from geochemical experiments for the first time.
Published: 2022
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19. Latest Results from the CUORE Experiment

Author: Nutini, I, Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Dell’Oro, S, Domizio, SD, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, YG, Kowalski, R, Ligi, C, Liu, R, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moggi, N, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, O’Donnell, T, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Rosenfeld, C, Rusconi, C, Sakai, M, Sangiorgio, S, Schmidt, B, Scielzo, ND, and Sharma, V
Subjects: Mathematical Physics, Classical Physics, Condensed Matter Physics, General Physics, Classical physics, Condensed matter physics
Abstract: The Cryogenic Underground Observatory for Rare Events (CUORE) is the first cryogenic experiment searching for 0 νββ decay that has been able to reach the one-tonne mass scale. The detector, located at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy, consists of an array of 988 TeO 2 crystals arranged in a compact cylindrical structure of 19 towers. CUORE began its first physics data run in 2017 at a base temperature of about 10 mK and in April 2021 released its 3 rd result of the search for 0 νββ, corresponding to a tonne-year of TeO 2 exposure. This is the largest amount of data ever acquired with a solid state detector and the most sensitive measurement of 0 νββ decay in 130Te ever conducted. We present the current status of CUORE search for 0 νββ with the updated statistics of one tonne-yr. We finally give an update of the CUORE background model and the measurement of the 130Te 2 νββ decay half-life and decay to excited states of 130Xe , studies performed using an exposure of 300.7 kg yr.
Published: 2022

20. Expected sensitivity to 128Te neutrinoless double beta decay with the CUORE TeO2 cryogenic bolometers

Author: Dompè, V, Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Dell’Oro, S, Di Domizio, S, Di Lorenzo, S, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Kowalski, R, Ligi, C, Liu, R, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moggi, N, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O’Donnell, T, Olmi, M, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, Rosenfeld, C, Rusconi, C, Sakai, M, and Sangiorgio, S
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Neutrinoless double beta decay, Tellurium, 128-Te, Cryogenic bolometers, Mathematical Physics, Classical Physics, Condensed Matter Physics, General Physics, Classical physics, Condensed matter physics
Abstract: The CUORE experiment is a ton-scale array of TeO 2 cryogenic bolometers located at the underground Laboratori Nazionali del Gran Sasso of Istituto Nazionale di Fisica Nucleare (INFN), in Italy. The CUORE detector consists of 988 crystals operated as source and detector at a base temperature of ∼ 10 mK. Such cryogenic temperature is reached and maintained by means of a custom built cryogen-free dilution cryostat, designed with the aim of minimizing the vibrational noise and the environmental radioactivity. The primary goal of CUORE is the search for neutrinoless double beta decay of 130Te , but thanks to its large target mass and ultra-low background it is suitable for the study of other rare processes as well, such as the neutrinoless double beta decay of 128Te. This tellurium isotope is an attractive candidate for the search of this process, due to its high natural isotopic abundance of 31.75%. The transition energy at (866.7 ± 0.7) keV lies in a highly populated region of the energy spectrum, dominated by the contribution of the two-neutrino double beta decay of 130Te. As the first ton-scale infrastructure operating cryogenic TeO 2 bolometers in stable conditions, CUORE is able to achieve a factor > 10 higher sensitivity to the neutrinoless double beta decay of this isotope with respect to past direct experiments.
Published: 2022

21. New Direct Limit on Neutrinoless Double Beta Decay Half-Life of Te128 with CUORE

Author: Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Capelli, C, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Del Corso, F, Dell’Oro, S, Di Domizio, S, Di Lorenzo, S, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gianvecchio, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Kowalski, R, Liu, R, Ma, L, G., Y, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O’Donnell, T, Olmi, M, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, Rosenfeld, C, Sangiorgio, S, and Schmidt, B
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Half-Life, Bayes Theorem, Granisetron, CUORE Collaboration, Mathematical Sciences, Engineering, General Physics, Mathematical sciences, Physical sciences
Abstract: The Cryogenic Underground Observatory for Rare Events (CUORE) at Laboratori Nazionali del Gran Sasso of INFN in Italy is an experiment searching for neutrinoless double beta (0νββ) decay. Its main goal is to investigate this decay in ^{130}Te, but its ton-scale mass and low background make CUORE sensitive to other rare processes as well. In this Letter, we present our first results on the search for 0νββ decay of ^{128}Te, the Te isotope with the second highest natural isotopic abundance. We find no evidence for this decay, and using a Bayesian analysis we set a lower limit on the ^{128}Te 0νββ decay half-life of T_{1/2}>3.6×10^{24} yr (90% CI). This represents the most stringent limit on the half-life of this isotope, improving by over a factor of 30 the previous direct search results, and exceeding those from geochemical experiments for the first time.
Published: 2022

22. An energy-dependent electro-thermal response model of CUORE cryogenic calorimeter

Author: Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Capelli, C, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D'Addabbo, A, Dafinei, I, Del Corso, F, Dell'Oro, S, Di Domizio, S, Di Lorenzo, S, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gianvecchio, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Kowalski, R, Li, M, Liu, R, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O'Donnell, T, Olmi, M, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, Rosenfeld, C, and Sangiorgio, S
Subjects: Nuclear and Plasma Physics, Synchrotrons and Accelerators, Physical Sciences, Cryogenic detectors, Detector modelling and simulations I (interaction of radiation with matter, interaction of photons with matter, interaction of hadrons with matter etc), Double-beta decay detectors, Engineering, Nuclear & Particles Physics, Physical sciences
Abstract: The Cryogenic Underground Observatory for Rare Events (CUORE) is the most sensitive experiment searching for neutrinoless double-beta decay (0νββ) in 130Te. CUORE uses a cryogenic array of 988 TeO2 calorimeters operated at ∼10 mK with a total mass of 741 kg. To further increase the sensitivity, the detector response must be well understood. Here, we present a non-linear thermal model for the CUORE experiment on a detector-by-detector basis. We have examined both equilibrium and dynamic electro-thermal models of detectors by numerically fitting non-linear differential equations to the detector data of a subset of CUORE channels which are well characterized and representative of all channels. We demonstrate that the hot-electron effect and electric-field dependence of resistance in NTD-Ge thermistors alone are inadequate to describe our detectors' energy-dependent pulse shapes. We introduce an empirical second-order correction factor in the exponential temperature dependence of the thermistor, which produces excellent agreement with energy-dependent pulse shape data up to 6 MeV. We also present a noise analysis using the fitted thermal parameters and show that the intrinsic thermal noise is negligible compared to the observed noise for our detectors.
Published: 2022

23. Enhanced low-energy supernova burst detection in large liquid argon time projection chambers enabled by Q-Pix

Author: Kubota, S., Ho, J., McDonald, A. D., Tata, N., Asaadi, J., Guenette, R., Battat, J. B. R., Braga, D., Demarteau, M., Djurcic, Z., Febbraro, M., Gramellini, E., Kohani, S., Mauger, C., Mei, Y., Newcomer, F. M., Nishimura, K., Nygren, D., Van Berg, R., Varner, G. S., and Woodworth, K.
Subjects: High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract: The detection of neutrinos from core-collapse supernovae may reveal important process features as well as neutrino properties. The detection of supernova neutrinos is one of the main science drivers for future kiloton-scale neutrino detectors based on liquid argon. Here we show that for such detectors the intrinsically 3D readout in Q-Pix offers numerous advantages relative to a wire-based readout, such as higher reconstruction efficiency, lower energy threshold, considerably lower data rates, and potential pointing information., Comment: 20 pages, 19 figures, 4 tables; accepted by Physical Review D
Published: 2022
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24. Snowmass 2021 White Paper: The Selena Neutrino Experiment

Author: Chavarria, A. E., Galbiati, C., Hernandez-Molinero, B., Ianni, Al., Li, X., Mei, Y., Montanino, D., Ni, X., Garay, C. Peña, Piers, A., and Wang, H.
Subjects: Physics - Instrumentation and Detectors
Abstract: Imaging devices made from an ionization target layer of amorphous selenium (aSe) coupled to a silicon complementary metal-oxide-semiconductor (CMOS) active pixel array for charge readout are a promising technology for neutrino physics. The high spatial resolution in a solid-state target provides unparalleled rejection of backgrounds from natural radioactivity in the search for neutrinoless $\beta\beta$ decay and for electron neutrino ($\nu_e$) spectroscopy with $^{82}$Se. In this white paper, we summarize the broad scientific program of a large imaging detector with a 10-ton target of $^{82}$Se. We review the detector technology, and outline the ongoing research program to realize this experiment., Comment: Contribution to Snowmass 2021
Published: 2022

25. Search for Neutrinoless $\beta^+EC$ Decay of $^{120}$Te with CUORE

Author: Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Canonica, L., Cao, X. G., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Copello, S., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Del Corso, F., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Huang, R. G., Huang, H. Z., Johnston, J., Keppel, G., Kolomensky, Yu. G., Kowalski, R., Ligi, C., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rosenfeld, C., Sakai, M., Sangiorgio, S., Schmidt, B., Scielzo, N. D., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Terranova, F., Tomei, C., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Wang, B. S., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.
Subjects: Nuclear Experiment
Abstract: CUORE is a large scale cryogenic experiment searching for neutrinoless double beta decay ($0\nu\beta\beta$) in $^{130}$Te. The CUORE detector is made of natural tellurium, providing the possibility of rare event searches on isotopes other than $^{130}$Te. In this work we describe a search for neutrinoless positron emitting electron capture ($0\nu\beta^+EC$) decay in $^{120}$Te with a total TeO$_2$ exposure of 355.7 kg $\cdot$ yr, corresponding to 0.2405 kg $\cdot$ yr of $^{120}$Te. Albeit $0 \nu \beta\beta$ with two final state electrons represents the most promising channel, the emission of a positron and two 511-keV $\gamma$s make $0\nu\beta^+EC$ decay signature extremely clear. To fully exploit the potential offered by the detector modularity we include events with different topology and perform a simultaneous fit of five selected signal signatures. Using blinded data we extract a median exclusion sensitivity of $3.4 \cdot 10^{22}$ yr at 90% Credibility Interval (C.I.). After unblinding we find no evidence of $0\nu\beta^+EC$ signal and set a 90% C.I. Bayesian lower limit of $2.9 \cdot 10^{22}$ yr on $^{120}$Te half-life. This result improves by an order of magnitude the existing limit from the combined analysis of CUORE-0 and Cuoricino.
Published: 2022
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26. Toward CUPID-1T

Author: Armatol, A., Augier, C., Avignone III, F. T., Azzolini, O., Balata, M., Ballen, K., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dabagov, S., Dafinei, I., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D., Helis, D. L., Huang, H. Z., Huang, R. G., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mauri, B., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J., Schmidt, B., Sharma, V., Shlegel, V., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.
Subjects: Nuclear Experiment
Abstract: Current experiments to search for broken lepton-number symmetry through the observation of neutrinoless double-beta decay ($0\mathrm{\nu\beta\beta}$) provide the most stringent limits on the Majorana nature of neutrinos and the effective Majorana neutrino mass ($m_{\beta\beta}$). The next-generation experiments will focus on the sensitivity to the $0\mathrm{\nu\beta\beta}$ half-life of $\mathcal{O}(10^{27}$--$10^{28}$~years$)$ and $m_{\beta\beta}\lesssim15$~meV, which would provide complete coverage of the so-called Inverted Ordering region of the neutrino mass parameter space. By taking advantage of recent technological breakthroughs, new, future calorimetric experiments at the 1-ton scale can increase the sensitivity by at least another order of magnitude, exploring the large fraction of the parameter space that corresponds to the Normal neutrino mass ordering. In case of a discovery, such experiments could provide important insights toward a new understanding of the mechanism of $0\mathrm{\nu\beta\beta}$. We present here a series of projects underway that will provide advancements in background reduction, cryogenic readout, and physics searches beyond $0\mathrm{\nu\beta\beta}$, all moving toward the next-to-next generation CUPID-1T detector., Comment: contribution to Snowmass 2021
Published: 2022

27. Recoil imaging for directional detection of dark matter, neutrinos, and physics beyond the Standard Model

Author: O'Hare, C. A. J., Loomba, D., Altenmüller, K., Álvarez-Pol, H., Amaro, F. D., Araújo, H. M., Sierra, D. Aristizabal, Asaadi, J., Attié, D., Aune, S., Awe, C., Ayyad, Y., Baracchini, E., Barbeau, P., Battat, J. B. R., Bell, N. F., Biasuzzi, B., Bignell, L. J., Boehm, C., Bolognino, I., Brunbauer, F. M., Caamaño, M., Cabo, C., Caratelli, D., Carmona, J. M., Castel, J. F., Cebrián, S., Cogollos, C., Collison, D., Costa, E., Dafni, T., Dastgiri, F., Deaconu, C., De Romeri, V., Desch, K., Dho, G., Di Giambattista, F., Díez-Ibáñez, D., D'Imperio, G., Dutta, B., Eldridge, C., Elliott, S. R., Ezeribe, A. C., Fava, A., Felkl, T., Fernández-Domínguez, B., Ribas, E. Ferrer, Flöthner, K. J., Froehlich, M., Galán, J., Galindo, J., García, F., Pascual, J. A. García, Gelli, B. P., Ghrear, M., Giomataris, Y., Gnanvo, K., Gramellini, E., Di Cortona, G. Grilli, Hall-Wilton, R., Harton, J., Hedges, S., Higashino, S., Hill, G., Holanda, P. C., Ikeda, T., Irastorza, I. G., Jackson, P., Janssens, D., Jones, B., Kaminski, J., Katsioulas, I., Kelly, K., Kemmerich, N., Kemp, E., Korandla, H. B., Kraus, H., Lackner, A., Lane, G. J., Lewis, P. M., Lisowska, M., Luzón, G., Lynch, W. A., Maccarrone, G., Mack, K. J., Majewski, P. A., Mano, R. D. P., Margalejo, C., Markoff, D., Marley, T., Marques, D. J. G., Massarczyk, R., Mazzitelli, G., McCabe, C., McKie, L. J., McLean, A. G., McNamara, P. C., Mei, Y., Messina, A., Mills, A. F., Mirallas, H., Miuchi, K., Monteiro, C. M. B., Mosbech, M. R., Muller, H., da Luz, H. Natal, Nakamura, K. D., Natochii, A., Neep, T., Newstead, J. L., Nikolopoulos, K., Obis, L., Oliveri, E., Orlandini, G., de Solórzano, A. Ortiz, von Oy, J., Papaevangelou, T., Pérez, O., Perez-Gonzalez, Y. F., Pfeiffer, D., Phan, N. S., Piacentini, S., Olloqui, E. Picatoste, Pinci, D., Popescu, S., Prajapati, A., Queiroz, F. S., Raaf, J. L., Resnati, F., Ropelewski, L., Roque, R. C., Ruiz-Choliz, E., Rusu, A., Ruz, J., Samarati, J., Santos, E. M., Santos, J. M. F. dos, Sauli, F., Scharenberg, L., Schiffer, T., Schmidt, S., Scholberg, K., Schott, M., Schueler, J., Segui, L., Sekiya, H., Sengupta, D., Slavkovska, Z., Snowden-Ifft, D., Soffitta, P., van Stenis, M., Spooner, N. J. C., Strigari, L., Stuchbery, A. E., Sun, X., Torelli, S., Tilly, E. G., Thomas, A. W., Thorpe, T. N., Urquijo, P., Utrobičić, A., Vahsen, S. E., Veenhof, R., Vogel, J. K., Williams, A. G., Wood, M. H., and Zettlemoyer, J.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract: Recoil imaging entails the detection of spatially resolved ionization tracks generated by particle interactions. This is a highly sought-after capability in many classes of detector, with broad applications across particle and astroparticle physics. However, at low energies, where ionization signatures are small in size, recoil imaging only seems to be a practical goal for micro-pattern gas detectors. This white paper outlines the physics case for recoil imaging, and puts forward a decadal plan to advance towards the directional detection of low-energy recoils with sensitivity and resolution close to fundamental performance limits. The science case covered includes: the discovery of dark matter into the neutrino fog, directional detection of sub-MeV solar neutrinos, the precision study of coherent-elastic neutrino-nucleus scattering, the detection of solar axions, the measurement of the Migdal effect, X-ray polarimetry, and several other applied physics goals. We also outline the R&D programs necessary to test concepts that are crucial to advance detector performance towards their fundamental limit: single primary electron sensitivity with full 3D spatial resolution at the $\sim$100 micron-scale. These advancements include: the use of negative ion drift, electron counting with high-definition electronic readout, time projection chambers with optical readout, and the possibility for nuclear recoil tracking in high-density gases such as argon. We also discuss the readout and electronics systems needed to scale-up such detectors to the ton-scale and beyond., Comment: 77 pages, 20 figures. Submitted to the Proceedings of the US Community Study on the Future of Particle Physics (Snowmass 2021)
Published: 2022

28. Optimization of the first CUPID detector module

Author: CUPID collaboration, Armatol, A., Augier, C., Avignone III, F. T., Azzolini, O., Balata, M., Ballen, K., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Beretta, M., Bettelli, M., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Capelli, C., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chang, C., Chiesa, D., Clemenza, M., Colantoni, I., Copello, S., Craft, E., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dabagov, S., Dafinei, I., Danevich, F. A., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Di Lorenzo, S., Dixon, T., Dompè, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Foggetta, L., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gallas, A., Gascon, J., Ghislandi, S., Giachero, A., Gianvecchio, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Grant, C., Gras, P., Guillaumon, P. V., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Huang, R. G., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Kowalski, R., Langford, T., Lefevre, M ., Liu, R., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mas, Ph., Mauri, B., Mayer, D., Mazzitelli, G., Mei, Y., Milana, S., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Olmi, M., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pattavina, L., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polischuk, O. G., Ponce, I., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Ressa, A., Rizzoli, R., Rosenfeld, C., Rosier, P., Scarpaci, J., Schmidt, B., Sharma, V., Shlegel, V., Singh, V., Sisti, M., Slocum, P., Speller, D., Surukuchi, P. T., Taffarello, L., Tomei, C., Torres, J., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Wang, R., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Umatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: CUPID will be a next generation experiment searching for the neutrinoless double $\beta$ decay, whose discovery would establish the Majorana nature of the neutrino. Based on the experience achieved with the CUORE experiment, presently taking data at LNGS, CUPID aims to reach a background free environment by means of scintillating Li$_{2}$$^{100}$MoO$_4$ crystals coupled to light detectors. Indeed, the simultaneous heat and light detection allows us to reject the dominant background of $\alpha$ particles, as proven by the CUPID-0 and CUPID-Mo demonstrators. In this work we present the results of the first test of the CUPID baseline module. In particular, we propose a new optimized detector structure and light sensors design to enhance the engineering and the light collection, respectively. We characterized the heat detectors, achieving an energy resolution of (5.9 $\pm$ 0.2) keV FWHM at the $Q$-value of $^{100}$Mo (about 3034 keV). We studied the light collection of the baseline CUPID design with respect to an alternative configuration which features gravity-assisted light detectors' mounting. In both cases we obtained an improvement in the light collection with respect to past measures and we validated the particle identification capability of the detector, which ensures an $\alpha$ particle rejection higher than 99.9%, fully satisfying the requirements for CUPID., Comment: 10 pages, 5 figures
Published: 2022

29. Search for neutrinoless β+EC decay of Te120 with CUORE

Author: Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, C, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D'Addabbo, A, Dafinei, I, Del Corso, F, Dell'Oro, S, Di Domizio, S, Di Lorenzo, S, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gianvecchio, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Kowalski, R, Ligi, C, Liu, R, Ma, L, G., Y, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O'Donnell, T, Olmi, M, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, Rosenfeld, C, and Sakai, M
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Synchrotrons and Accelerators, Physical Sciences, Cardiovascular, Nuclear and plasma physics
Abstract: The Cryogenic Underground Observatory for Rare Events (CUORE) is a large-scale cryogenic experiment searching for neutrinoless double-beta decay (0νββ) in Te130. The CUORE detector is made of natural tellurium, providing the possibility of rare event searches on isotopes other than Te130. In this work we describe a search for neutrinoless positron-emitting electron capture (β+EC) decay in Te120 with a total TeO2 exposure of 355.7 kg yr, corresponding to 0.2405 kg yr of Te120. Albeit 0νββ with two final-state electrons represents the most promising channel, the emission of a positron and two 511-keV γ's make 0νβ+EC decay signature extremely clear. To fully exploit the potential offered by the detector modularity we include events with different topology and perform a simultaneous fit of five selected signal signatures. Using blinded data we extract a median exclusion sensitivity of 3.4×1022 yr at 90% credibility interval (C.I.). After unblinding we find no evidence of 0νβ+EC signal and set a 90% C.I. Bayesian lower limit of 2.9×1022 yr on Te120 half-life. This result improves by an order of magnitude the existing limit from the combined analysis of CUORE-0 and Cuoricino.
Published: 2022

30. Search for Majorana neutrinos exploiting millikelvin cryogenics with CUORE

Author: Adams, DQ, Alduino, C, Alfonso, K, Avignone, FTIII, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D'Addabbo, A, Dafinei, I, Dell'Oro, S, Di Domizio, S, Dompe, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Ligi, C, Liu, R, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moggi, N, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O'Donnell, T, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Rosenfeld, C, Rusconi, C, Sakai, M, Sangiorgio, S, Schmidt, B, Scielzo, ND, Sharma, V, Singh, V, Sisti, M, and Speller, D
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, CUORE Collaboration, nucl-ex, General Science & Technology
Abstract: The possibility that neutrinos may be their own antiparticles, unique among the known fundamental particles, arises from the symmetric theory of fermions proposed by Ettore Majorana in 19371. Given the profound consequences of such Majorana neutrinos, among which is a potential explanation for the matter-antimatter asymmetry of the universe via leptogenesis2, the Majorana nature of neutrinos commands intense experimental scrutiny globally; one of the primary experimental probes is neutrinoless double beta (0νββ) decay. Here we show results from the search for 0νββ decay of 130Te, using the latest advanced cryogenic calorimeters with the CUORE experiment3. CUORE, operating just 10 millikelvin above absolute zero, has pushed the state of the art on three frontiers: the sheer mass held at such ultralow temperatures, operational longevity, and the low levels of ionizing radiation emanating from the cryogenic infrastructure. We find no evidence for 0νββ decay and set a lower bound of the process half-life as 2.2 × 1025 years at a 90 per cent credibility interval. We discuss potential applications of the advances made with CUORE to other fields such as direct dark matter, neutrino and nuclear physics searches and large-scale quantum computing, which can benefit from sustained operation of large payloads in a low-radioactivity, ultralow-temperature cryogenic environment.
Published: 2022

31. Development of a direct-sampling RF receiver for precision beam charge measurements in the MOLLER experiment

Author: Mei, Y, Li, S, Arrington, J, Camilleri, J, Cuda, A, Egelhoff, J, Kolomensky, Yu G, and Sichtermann, EP
Subjects: Nuclear and Plasma Physics, Synchrotrons and Accelerators, Physical Sciences, Good Health and Well Being, Beam-line instrumentation (beam position and profile monitors, beam-intensity monitors, bunch length monitors), Microwave radiometers, Digital signal processing, Engineering, Nuclear & Particles Physics, Physical sciences
Abstract: We have developed and tested a direct-sampling RF receiver capable of measuring the amplitude of a 1497 MHz sinusoidal beam signal in 0.5 ms integration windows with a relative uncertainty of better than 10 parts per million. The receiver is intended for measuring signals from beam current monitoring cavities on the beamline of the Continuous Electron Beam Accelerator Facility (CEBAF) at Jefferson Lab. The beam signal strength, frequency, and integration window fulfill the thus far unmet requirements of the upcoming MOLLER experiment to measure the beam charge for different helicity states.
Published: 2022

32. CUORE Opens the Door to Tonne-scale Cryogenics Experiments

Author: CUORE Collaboration, Adams, D. Q., Alduino, C., Alessandria, F., Alfonso, K., Andreotti, E., Avignone III, F. T., Azzolini, O., Balata, M., Bandac, I., Banks, T. I., Bari, G., Barucci, M., Beeman, J. W., Bellini, F., Benato, G., Beretta, M., Bersani, A., Biare, D., Biassoni, M., Bragazzi, F., Branca, A., Brofferio, C., Bryant, A., Buccheri, A., Bucci, C., Bulfon, C., Camacho, A., Camilleri, J., Caminata, A., Campani, A., Canonica, L., Cao, X. G., Capelli, S., Capodiferro, M., Cappelli, L., Cardani, L., Cariello, M., Carniti, P., Carrettoni, M., Casali, N., Cassina, L., Celi, E., Cereseto, R., Ceruti, G., Chiarini, A., Chiesa, D., Chott, N., Clemenza, M., Conventi, D., Copello, S., Cosmelli, C., Cremonesi, O., Crescentini, C., Creswick, R. J., Cushman, J. S., D'Addabbo, A., D'Aguanno, D., Dafinei, I., Datskov, V., Davis, C. J., Del Corso, F., Dell'Oro, S., Deninno, M. M., Di Domizio, S., Dompè, V., Di Vacri, M. L., Di Paolo, L., Drobizhev, A., Ejzak, L., Faccini, R., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Gaigher, R., Ghislandi, S., Giachero, A., Gironi, L., Giuliani, A., Gladstone, L., Goett, J., Gorla, P., Gotti, C., Guandalini, C., Guerzoni, M., Guetti, M., Gutierrez, T. D., Haller, E. E., Han, K., Hansen, E. V., Heeger, K. M., Hennings-Yeomans, R., Hickerson, K. P., Huang, R. G., Huang, H. Z., Iannone, M., Ioannucci, L., Johnston, J., Kadel, R., Keppel, G., Kogler, L., Kolomensky, Yu. G., Leder, A., Ligi, C., Lim, K. E., Liu, R., Ma, L., Ma, Y. G., Maiano, C., Maino, M., Marini, L., Martinez, M., Amaya, C. Martinez, Maruyama, R. H., Mayer, D., Mazza, R., Mei, Y., Moggi, N., Morganti, S., Mosteiro, P. J., Nagorny, S. S., Napolitano, T., Nastasi, M., Nikkel, J., Nisi, S., Nones, C., Norman, E. B., Novati, V., Nucciotti, A., Nutini, I., O'Donnell, T., Olcese, M., Olivieri, E., Orio, F., Orlandi, D., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Palmieri, V., Pattavina, L., Pavan, M., Pedretti, M., Pedrotta, R., Pelosi, A., Perego, M., Pessina, G., Pettinacci, V., Piperno, G., Pira, C., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Quitadamo, S., Reindl, F., Rimondi, F., Risegari, L., Rosenfeld, C., Rossi, C., Rusconi, C., Sakai, M., Sala, E., Salvioni, C., Sangiorgio, S., Santone, D., Schaeffer, D., Schmidt, B., Schmidt, J., Scielzo, N. D., Sharma, V., Singh, V., Sisti, M., Smith, A. R., Speller, D., Stivanello, F., Surukuchi, P. T., Taffarello, L., Tatananni, L., Tenconi, M., Terranova, F., Tessaro, M., Tomei, C., Ventura, G., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Wallig, J., Wang, B. S., Wang, H. W., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Wise, T., Zanotti, L., Zarra, C., Zhang, G. Q., Zhu, B. X., Zimmermann, S., and Zucchelli, S.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: The past few decades have seen major developments in the design and operation of cryogenic particle detectors. This technology offers an extremely good energy resolution - comparable to semiconductor detectors - and a wide choice of target materials, making low temperature calorimetric detectors ideal for a variety of particle physics applications. Rare event searches have continued to require ever greater exposures, which has driven them to ever larger cryogenic detectors, with the CUORE experiment being the first to reach a tonne-scale, mK-cooled, experimental mass. CUORE, designed to search for neutrinoless double beta decay, has been operational since 2017 at a temperature of about 10 mK. This result has been attained by the use of an unprecedentedly large cryogenic infrastructure called the CUORE cryostat: conceived, designed and commissioned for this purpose. In this article the main characteristics and features of the cryogenic facility developed for the CUORE experiment are highlighted. A brief introduction of the evolution of the field and of the past cryogenic facilities are given. The motivation behind the design and development of the CUORE cryogenic facility is detailed as are the steps taken toward realization, commissioning, and operation of the CUORE cryostat. The major challenges overcome by the collaboration and the solutions implemented throughout the building of the cryogenic facility will be discussed along with the potential improvements for future facilities. The success of CUORE has opened the door to a new generation of large-scale cryogenic facilities in numerous fields of science. Broader implications of the incredible feat achieved by the CUORE collaboration on the future cryogenic facilities in various fields ranging from neutrino and dark matter experiments to quantum computing will be examined., Comment: 45 pages, 14 figures
Published: 2021
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33. Downregulation of lncRNA ANRIL Suppresses Growth and Metastasis in Human Osteosarcoma Cells [Retraction]

Author: Guan H, Mei Y, Mi Y, Li C, Sun X, Zhao X, Liu J, Cao W, Li Y, and Wang Y
Subjects: osteosarcoma, anril, proliferation, invasion, apoptosis, long noncoding rna, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract: Guan H, Mei Y, Mi Y, et al. Onco Targets Ther. 2018;11:4893-4899. We, the Editor and Publisher of the journal OncoTargets and Therapy have retracted the published article. Following publication of the article, concerns were raised about the duplication of images from Figure 4 with images from an unrelated article. Specifically, The images for Figure 4B, NC and si-ANRIL, have been duplicated with images for Figure 2C, NC and miR-183, 48h, respectively from Sun X, Xu Y, Zhang S, et al. (2018). MicroRNA‑183 suppresses the vitality, invasion and migration of human osteosarcoma cells by targeting metastasis‑associated protein 110.3892/etm.2021.10947. Experimental and Therapeutic Medicine. 2018;15:5058-5064. https://doi.org/10.3892/etm.2018.6068. In addition, the images for Figure 4A, NC and si-ANRIL, 0h and 4A, Blank and NC, 12h, have been duplicated. The corresponding author did not respond to our queries and was unable to provide a satisfactory explanation for how the images came to be duplicated or provide satisfactory original data for the study. As verifying the validity of published work is core to the integrity of the scholarly record, the Publisher and Editor requested to retract the article and the corresponding author was notified of this. We have been informed in our decision-making by our editorial policies and COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.
Published: 2024

34. Latest results from the CUORE experiment

Author: Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Capelli, C, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D'Addabbo, A, Dafinei, I, Dell'Oro, S, Di Domizio, S, Di Lorenzo, S, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Ghislandi, S, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, YG, Kowalski, R, Ligi, C, Liu, R, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O'Donnell, T, Olmi, M, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Quitadamo, S, Ressa, A, Rosenfeld, C, Rusconi, C, Sakai, M, and Sangiorgio, S
Abstract: The CUORE experiment is searching for the neutrinoless double β decay of the 130Te using cryogenic calorimeters. The CUORE detector consists of 988 TeO2 crystals packed in 19 towers and placed in a cryogenic facility with a base temperature of 10 mK. Crystals are enriched in the isotope 130Te which is the candidate for the neutrinoless double β decay. It is taking data since 2017 at the Laboratori Nazionali del Gran Sasso in Italy. Such a long operation of a bolometric experiment in stable condition has no precedent: by reaching 1 tonne-year of exposure CUORE set a fundamental milestone for any future experiment using this technology. The CUORE collaboration investigated the neutrinoless double β decay of 130Te exploiting the updated 1 tonne-year of statistics, setting a limit of 2.2 × 1025 yr at the 90% of credibility interval on the half-life, with a median sensitivity of 2.8 × 1025 yr.
Published: 2022

35. New results from the CUORE experiment

Author: Nutini, I, Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT, Azzolini, O, Bari, G, Bellini, F, Benato, G, Beretta, M, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Dell’Oro, S, Di Domizio, S, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Ligi, C, Ma, L, G., Y, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moggi, N, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, O’Donnell, T, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Rosenfeld, C, Rusconi, C, Sakai, M, Sangiorgio, S, Schmidt, B, Scielzo, ND, Sharma, V, Singh, V, Sisti, M, Speller, D, and Surukuchi, PT
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Neutrinoless double beta decay, two-neutrino double beta decay, background model, cryogenic detectors, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Nuclear & Particles Physics, Astronomical sciences, Nuclear and plasma physics, Particle and high energy physics
Abstract: The Cryogenic Underground Observatory for Rare Events (CUORE) is the first bolometric experiment searching for neutrino-less double-beta (0νββ) decay that has been able to reach the one-ton scale. The detector, located at the Laboratori Nazionali del Gran Sasso in Italy, consists of an array of 988 TeO2 crystals arranged in a compact cylindrical structure of 19 towers. Following the completion of the detector construction in August 2016, CUORE began its first physics data run in 2017 at a base temperature of about 10 mK. Following multiple optimization campaigns in 2018, CUORE is currently in stable operating mode. In 2019, CUORE released its second result of the search for 0νββ corresponding to a TeO2 exposure of 372.5 kgyr and a median exclusion sensitivity to a 130Te 0νββ decay half-life of 1.7 1025 yr. We find no evidence for 0νββ decay and set a 90% C.I. Bayesian lower limit of 3.2 1025 yr on the 130Te 0νββ decay half-life. We present the current status of CUORE's search for 0νββ. We give an update of the CUORE background model and the measurement of the 130Te two neutrino double-beta (2νββ) decay half-life. Eventually, we show the preliminary results on half-life limits from the analysis of 130Te 0νββ and 2νββ decay to the first 0+ excited state of 130Xe.
Published: 2022

36. Search for Majorana neutrinos exploiting millikelvin cryogenics with CUORE

Author: Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Beretta, M., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Canonica, L., Cao, X. G., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Copello, S., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Dell'Oro, S., Di Domizio, S., Dompe', V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Giachero, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Huang, R. G., Huang, H. Z., Johnston, J., Keppel, G., Kolomensky, Yu. G., Ligi, C., Liu, R., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Moggi, N., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Rosenfeld, C., Rusconi, C., Sakai, M., Sangiorgio, S., Schmidt, B., Scielzo, N. D., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Terranova, F., Tomei, C., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Wang, B. S., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.
Subjects: Nuclear Experiment
Abstract: The possibility that neutrinos may be their own antiparticles, unique among the known fundamental particles, arises from the symmetric theory of fermions proposed by Ettore Majorana in 1937. Given the profound consequences of such Majorana neutrinos, among which is a potential explanation for the matter-antimatter asymmetry of the universe via leptogenesis, the Majorana nature of neutrinos commands intense experimental scrutiny globally; one of the primary experimental probes is neutrinoless double beta ($0 \nu \beta \beta$) decay. Here we show results from the search for $0 \nu \beta \beta$ decay of $^{130}$Te, using the latest advanced cryogenic calorimeters with the CUORE experiment. CUORE, operating just 10 millikelvin above absolute zero, has pushed the state of the art on three frontiers: the sheer mass held at such ultra-low temperatures, operational longevity, and the low levels of ionising radiation emanating from the cryogenic infrastructure. We find no evidence for $0 \nu \beta \beta$ decay and set a lower bound of $T_{1/2}^{0 \nu} > 2.2 \times 10^{25}$ years at a 90% credibility interval. We discuss potential applications of the advances made with CUORE to other fields such as direct dark matter, neutrino and nuclear physics searches and large-scale quantum computing, which can benefit from sustained operation of large payloads in a low-radioactivity, ultra-low temperature cryogenic environment.
Published: 2021
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37. Nondestructive Testing of Medium Manganese Steel Based on Barkhausen

Author: Mei, Y. Q., Pei, J. S., Zhu, B., Zhang, Y. S., Xiao, Shengxiong, Editor-in-Chief, Bassir, David, Series Editor, Gao, Bingbing, Series Editor, Jiang, Yongchao, Series Editor, Li, Jia, Series Editor, Mazumdar, Sayantan, Series Editor, Sun, Qijun, Series Editor, Tang, Juntao, Series Editor, Xiong, Chuanyin, Series Editor, Xu, Hexiu, Series Editor, Yang, Jun, Series Editor, Zhang, Yisheng, editor, and Ma, Mingtu, editor
Published: 2023
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38. Establishment and Validation of a Nomogram Prediction Model for the Severe Acute Pancreatitis

Author: Li B, Wu W, Liu A, Feng L, Mei Y, Tan L, Zhang C, and Tian Y
Subjects: acute pancreatitis, prediction model, risk factor, nomogram, decision curve analysis, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Bo Li,1 Weiqing Wu,1 Aijun Liu,1 Lifeng Feng,1 Bin Li,1 Yong Mei,1 Li Tan,1 Chaoyang Zhang,2 Yangtao Tian1 1Department of Pancreatic Surgery, Shangluo Center Hospital, Shangluo, Shaanxi, 726000, People’s Republic of China; 2Department of Ultrasound Medicine, Shangluo Center Hospital, Shangluo, Shaanxi, 726000, People’s Republic of ChinaCorrespondence: Yangtao Tian, Department of Pancreatic Surgery, Shangluo Center Hospital, 37 Shangyang, Shangzhou, Shangluo, Shaanxi, 726000, People’s Republic of China, Email 928763821@qq.comBackground: Severe acute pancreatitis (SAP) can progress to lung and kidney dysfunction, and blood clotting within 48 hours of its onset, and is associated with a high mortality rate. The aim of this study was to establish a reliable diagnostic prediction model for the early stage of severe pancreatitis.Methods: The clinical data of patients diagnosed with acute pancreatitis from October 2017 to June 2022 at the Shangluo Central Hospital were collected. The risk factors were screened by least absolute shrinkage and selection operator (LASSO) regression analysis. A novel nomogram model was then established by multivariable logistic regression analysis.Results: The data of 436 patients with acute pancreatitis, 45 (10.3%) patients had progressed to SAP. Through univariate and LASSO regression analyses, the neutrophils (P < 0.001), albumin (P < 0.001), blood glucose (P < 0.001), serum calcium (P < 0.001), serum creatinine (P < 0.001), blood urea nitrogen (P < 0.001) and procalcitonin (P = 0.005) were identified as independent predictive factors for SAP. The nomogram built on the basis of these factors predicted SAP with sensitivity of 0.733, specificity of 0.9, positive predictive value of 0.458 and negative predictive value of 0.967. Furthermore, the concordance index of the nomogram reached 0.889 (95% CI, 0.837– 0.941), and the area under the curve (AUC) in receiver operating characteristic curve (ROC) analysis was significantly higher than that of the APACHEII and ABISAP scoring systems. The established model was validated by plotting the clinical decision curve analysis (DCA) and clinical impact curve (CIC).Conclusion: We established a nomogram to predict the progression of early acute pancreatitis to SAP with high discrimination and accuracy.Keywords: acute pancreatitis, prediction model, risk factor, nomogram, decision curve analysis
Published: 2023

39. IL-2/JES6-1 Antibody Complex Expands the Maternal T-Regulatory Cell Pool and Alleviates Fetal Loss in Abortion-Prone Mice

Author: Foyle, Kerrie L., Chin, Peck Y., Merkwirth, Carsten, Wilson, Jasmine, Hosking, Shanna L., Green, Ella S., Chong, Mei Y., Zhang, Bihong, Moldenhauer, Lachlan M., Ferguson, Greg D., Morris, Gerald P., Karras, James G., Care, Alison S., and Robertson, Sarah A.
Published: 2024
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40. Search for Double-Beta Decay of $\mathrm{^{130}Te}$ to the $0^+$ States of $\mathrm{^{130}Xe}$ with CUORE

Author: CUORE Collaboration, Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Branca, M. Biassoni A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Canonica, L., Cao, X. G., Capelli, S., Cappelli, L., Cardani, L., Casali, P. Carniti N., Celi, E., Copello, D. Chiesa M. Clemenza S., Cosmelli, C., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Davis, C. J., Di Domizio, S. Dell'Oro S., Dompè, V., Fang, D. Q., Fantini, G., Ferri, M. Faverzani E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Giachero, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Gutierrez, T. D., Han, K., Heeger, K. M., Huang, R. G., Huang, H. Z., Johnston, J., Keppel, G., Kolomensky, Yu. G., Ligi, C., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Moggi, N., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Rosenfeld, C., Rusconi, C., Sakai, M., Sangiorgio, S., Schmidt, B., Scielzo, N. D., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Terranova, F., Tomei, C., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Wang, B. S., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.
Subjects: Nuclear Experiment
Abstract: The CUORE experiment is a large bolometric array searching for the lepton number violating neutrino-less double beta decay ($0\nu\beta\beta$) in the isotope $\mathrm{^{130}Te}$. In this work we present the latest results on two searches for the double beta decay (DBD) of $\mathrm{^{130}Te}$ to the first $0^{+}_2$ excited state of $\mathrm{^{130}Xe}$: the $0\nu\beta\beta$ decay and the Standard Model-allowed two-neutrinos double beta decay ($2\nu\beta\beta$). Both searches are based on a 372.5 kg$\times$yr TeO$_2$ exposure. The de-excitation gamma rays emitted by the excited Xe nucleus in the final state yield a unique signature, which can be searched for with low background by studying coincident events in two or more bolometers. The closely packed arrangement of the CUORE crystals constitutes a significant advantage in this regard. The median limit setting sensitivities at 90\% Credible Interval (C.I.) of the given searches were estimated as $\mathrm{S^{0\nu}_{1/2} = 5.6 \times 10^{24} \: \mathrm{yr}}$ for the ${0\nu\beta\beta}$ decay and $\mathrm{S^{2\nu}_{1/2} = 2.1 \times 10^{24} \: \mathrm{yr}}$ for the ${2\nu\beta\beta}$ decay. No significant evidence for either of the decay modes was observed and a Bayesian lower bound at $90\%$ C.I. on the decay half lives is obtained as: $\mathrm{(T_{1/2})^{0\nu}_{0^+_2} > 5.9 \times 10^{24} \: \mathrm{yr}}$ for the $0\nu\beta\beta$ mode and $\mathrm{(T_{1/2})^{2\nu}_{0^+_2} > 1.3 \times 10^{24} \: \mathrm{yr}}$ for the $2\nu\beta\beta$ mode. These represent the most stringent limits on the DBD of $^{130}$Te to excited states and improve by a factor $\sim5$ the previous results on this process., Comment: 13 pages, 6 figures
Published: 2021
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41. Optimization of a single module of CUPID

Author: Ressa, Alberto, Armatol, A, Armengaud, E, Armstrong, W, Augier, C, Avignone, FT, Azzolini, O, Barabash, A, Bari, G, Barresi, A, Baudin, D, Bellini, F, Benato, G, Beretta, M, Bergé, L, Biassoni, M, Billard, J, Boldrini, V, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Cazes, A, Celi, E, Chang, A, Chapellier, M, Charrier, A, Chiesa, D, Clemenza, M, Colantoni, I, Collamati, F, Copello, S, Cremonesi, O, Creswick, RJ, Cruciani, A, Addabbo, A D’, Imperio, G D’, Dafinei, I, Danevich, FA, de Combarieu, M, De Jesus, M, de Marcillac, P, Dell’Oro, S, Di Domizio, S, Dompè, V, Drobizhev, A, Dumoulin, L, Fantini, G, Faverzani, M, Ferri, E, Ferri, F, Ferroni, F, Figueroa-Feliciano, E, Formaggio, J, Franceschi, A, Fu, C, Fu, S, Fujikawa, BK, Gascon, J, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gras, P, Gros, M, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Helis, BL, Huang, HZ, Huang, RG, Imbert, L, Johnston, J, Juillard, A, Karapetrov, G, Keppel, G, Khalife, H, Kobychev, VV, Kolomensky, Yu G, Konovalov, S, Liu, Y, Loaiza, P, Ma, L, Madhukuttan, M, Mancarella, F, Mariam, R, Marini, L, Marnieros, S, Martinez, M, Maruyama, RH, Mauri, B, Mayer, D, and Mei, Y
Subjects: Atomic, Molecular, Nuclear, Particle and Plasma Physics, Condensed Matter Physics, Other Physical Sciences
Abstract: CUPID is the next generation experiment which will use scintillating cryogenic calorimeters to search for the neutrinoless double β decay. This unobserved process would shed light on the nature of the neutrino, which up to our knowledge could be a Majorana or a Dirac particle, and would give us an important hint to explain the lack of antimatter in the universe. This ambitious search needs a detector with unique characteristics such as an extremely low background level and an excellent energy resolution. CUPID is now in advanced R&D state to optimize the detector design in order to completely exploit the potentialities of scintillating cryogenic calorimeters. In the following I will describe the test performed at the LNGS (Laboratori Nazionali del Gran Sasso) of a single module of the future CUPID detector. In this contribution we present the performance obtained with a novel assembly concept, proving that it matches the requirements for CUPID.
Published: 2021

42. Measurement of the 2$\nu\beta\beta$ Decay Half-life of $^{130}$Te with CUORE

Author: CUORE Collaboration, Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Canonica, L., Cao, X. G., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Chiesa, D., Clemenza, M., Copello, S., Cosmelli, C., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Davis, C. J., Dell'Oro, S., Di Domizio, S., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Giachero, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Gutierrez, T. D., Han, K., Heeger, K. M., Huang, R. G., Huang, H. Z., Johnston, J., Keppel, G., Kolomensky, Yu. G., Ligi, C., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Moggi, N., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Rosenfeld, C., Rusconi, C., Sakai, M., Sangiorgio, S., Schmidt, B., Scielzo, N. D., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Terranova, F., Tomei, C., Vetter, K. J., Vignati, M., Wagaarachchi, S. L., Wang, B. S., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.
Subjects: Nuclear Experiment, J.2
Abstract: We measured two-neutrino double beta decay of $^{130}$Te using an exposure of 300.7 kg$\cdot$yr accumulated with the CUORE detector. Using a Bayesian analysis to fit simulated spectra to experimental data, it was possible to disentangle all the major background sources and precisely measure the two-neutrino contribution. The half-life is in agreement with past measurements with a strongly reduced uncertainty: $T^{2\nu}_{1/2} = 7.71^{+0.08}_{-0.06}\mathrm{(stat.)}^{+0.12}_{-0.15}\mathrm{(syst.)}\times10^{20}$ yr. This measurement is the most precise determination of the $^{130}$Te 2$\nu\beta\beta$ decay half-life to date., Comment: Published in PRL
Published: 2020
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43. A CUPID Li$_{2}$$^{100}$MoO$_4$ scintillating bolometer tested in the CROSS underground facility

Author: The CUPID Interest Group, Armatol, A., Armengaud, E., Armstrong, W., Augier, C., Avignone III, F. T., Azzolini, O., Bandac, I. C., Barabash, A. S., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Beretta, M., Bergé, L., Bourgeois, Ch., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Calvo-Mozota, J. M., Camilleri, J., Candela, A., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Cazes, A., Celi, E., Chang, C., Chapellier, M., Charrier, A., Chiesa, D., Clemenza, M., Colantoni, I., Collamati, F., Copello, S., Cova, F., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dafinei, I., Danevich, F. A., de Combarieu, M., De Deo, M., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Dompe, V., Drobizhev, A., Dumoulin, L., Fantini, G., Fasoli, M., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gascon, J., Giachero, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Gras, P., Gros, M., Guerard, E., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Huang, R. G., Ianni, A., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S. I., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Mariam, R., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mauri, B., Mayer, D., Mei, Y., Milana, S., Misiak, D., Napolitano, T., Nastasi, M., Navick, X. -F., Nikkel, J., Nipoti, R., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivier, G., Olivieri, E., Oriol, C., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pari, P., Pattavina, L., Paul, B., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polakovic, T., Polischuk, O. G., Pozzi, S., Previtali, E., Puiu, A., Ressa, A., Reynet, D., Rizzoli, R., Rosenfeld, C., Sanglard, V., Scarpaci, J. A., Schmidt, B., Sharma, V., Shlegel, V. N., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Tellier, O., Tomei, C., Tretyak, V. I., Tsymbaliuk, A., Vedda, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Yumatov, V. I., Zarytskyy, M. M., Zhang, J., Zolotarova, A. S., and Zucchelli, S.
Subjects: Physics - Instrumentation and Detectors
Abstract: A scintillating bolometer based on a large cubic Li$_{2}$$^{100}$MoO$_4$ crystal (45 mm side) and a Ge wafer (scintillation detector) has been operated in the CROSS cryogenic facility at the Canfranc underground laboratory in Spain. The dual-readout detector is a prototype of the technology that will be used in the next-generation $0\nu2\beta$ experiment CUPID. The measurements were performed at 18 and 12 mK temperature in a pulse tube dilution refrigerator. This setup utilizes the same technology as the CUORE cryostat that will host CUPID and so represents an accurate estimation of the expected performance. The Li$_{2}$$^{100}$MoO$_4$ bolometer shows a high energy resolution of 6 keV FWHM at the 2615 keV $\gamma$ line. The detection of scintillation light for each event triggered by the Li$_{2}$$^{100}$MoO$_4$ bolometer allowed for a full separation ($\sim$8$\sigma$) between $\gamma$($\beta$) and $\alpha$ events above 2 MeV. The Li$_{2}$$^{100}$MoO$_4$ crystal also shows a high internal radiopurity with $^{228}$Th and $^{226}$Ra activities of less than 3 and 8 $\mu$Bq/kg, respectively. Taking also into account the advantage of a more compact and massive detector array, which can be made of cubic-shaped crystals (compared to the cylindrical ones), this test demonstrates the great potential of cubic Li$_{2}$$^{100}$MoO$_4$ scintillating bolometers for high-sensitivity searches for the $^{100}$Mo $0\nu2\beta$ decay in CROSS and CUPID projects., Comment: 19 pages, 7 figures, 1 table
Published: 2020
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44. Characterization of cubic Li$_{2}$$^{100}$MoO$_4$ crystals for the CUPID experiment

Author: Armatol, A., Armengaud, E., Armstrong, W., Augier, C., Avignone III, F. T., Azzolini, O., Barabash, A., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Beretta, M., Bergè, L., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Cazes, A., Celi, E., Chang, C., Chapellier, M., Charrier, A., Chiesa, D., Clemenza, M., Colantoni, I., Collamati, F., Copello, S., Cova, F., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dafinei, I., Danevich, F. A., de Combarieu, M., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Dompé, V., Drobizhev, A., Dumoulin, L., Fantini, G., Fasoli, M., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gascon, J., Giachero, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Gras, P., Gros, M., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Huang, R. G., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Mariam, R., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mauri, B., Mayer, D., Mei, Y., Milana, S., Misiak, D., Napolitano, T., Nastasi, M., Navick, X. F., Nikkel, J., Nipoti, R., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Oriol, C., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pari, P., Pattavina, L., Paul, B., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polakovic, T., Polischuk, O. G., Pozzi, S., Previtali, E., Puiu, A., Ressa, A., Rizzoli, R., Rosenfeld, C., Rusconi, C., Sanglard, V., Scarpaci, J. A., Schmidt, B., Sharma, V., Shlegel, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Tellier, O., Tomei, C., Tretyak, V. I., Tsymbaliuk, A., Vedda, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Yumatov, V., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: The CUPID Collaboration is designing a tonne-scale, background-free detector to search for double beta decay with sufficient sensitivity to fully explore the parameter space corresponding to the inverted neutrino mass hierarchy scenario. One of the CUPID demonstrators, CUPID-Mo, has proved the potential of enriched Li$_{2}$$^{100}$MoO$_4$ crystals as suitable detectors for neutrinoless double beta decay search. In this work, we characterised cubic crystals that, compared to the cylindrical crystals used by CUPID-Mo, are more appealing for the construction of tightly packed arrays. We measured an average energy resolution of (6.7$\pm$0.6) keV FWHM in the region of interest, approaching the CUPID target of 5 keV FWHM. We assessed the identification of $\alpha$ particles with and without a reflecting foil that enhances the scintillation light collection efficiency, proving that the baseline design of CUPID already ensures a complete suppression of this $\alpha$-induced background contribution. We also used the collected data to validate a Monte Carlo simulation modelling the light collection efficiency, which will enable further optimisations of the detector.
Published: 2020

45. Novel technique for the study of pile-up events in cryogenic bolometers

Author: Armatol, A., Armengaud, E., Armstrong, W., Augier, C., Avignone III, F. T., Azzolini, O., Barabash, A., Bari, G., Barresi, A., Baudin, D., Bellini, F., Benato, G., Beretta, M., Bergé, L., Biassoni, M., Billard, J., Boldrini, V., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Cazes, A., Celi, E., Chang, C., Chapellier, M., Charrier, A., Chiesa, D., Clemenza, M., Colantoni, I., Collamati, F., Copello, S., Cremonesi, O., Creswick, R. J., Cruciani, A., D'Addabbo, A., D'Imperio, G., Dafinei, I., Danevich, F. A., de Combarieu, M., De Jesus, M., de Marcillac, P., Dell'Oro, S., Di Domizio, S., Dompè, V., Drobizhev, A., Dumoulin, L., Fantini, G., Faverzani, M., Ferri, E., Ferri, F., Ferroni, F., Figueroa-Feliciano, E., Formaggio, J., Franceschi, A., Fu, C., Fu, S., Fujikawa, B. K., Gascon, J., Giachero, A., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Gras, P., Gros, M., Gutierrez, T. D., Han, K., Hansen, E. V., Heeger, K. M., Helis, D. L., Huang, H. Z., Huang, R. G., Imbert, L., Johnston, J., Juillard, A., Karapetrov, G., Keppel, G., Khalife, H., Kobychev, V. V., Kolomensky, Yu. G., Konovalov, S., Liu, Y., Loaiza, P., Ma, L., Madhukuttan, M., Mancarella, F., Mariam, R., Marini, L., Marnieros, S., Martinez, M., Maruyama, R. H., Mauri, B., Mayer, D., Mei, Y., Milana, S., Misiak, D., Napolitano, T., Nastasi, M., Navick, X. F., Nikkel, J., Nipoti, R., Nisi, S., Nones, C., Norman, E. B., Novosad, V., Nutini, I., O'Donnell, T., Olivieri, E., Oriol, C., Ouellet, J. L., Pagan, S., Pagliarone, C., Pagnanini, L., Pari, P., Pattavina, L., Paul, B., Pavan, M., Peng, H., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Poda, D. V., Polakovic, T., Polischuk, O. G., Pozzi, S., Previtali, E., Puiu, A., Ressa, A., Rizzoli, R., Rosenfeld, C., Rusconi, C., Sanglard, V., Scarpaci, J., Schmidt, B., Sharma, V., Shlegel, V., Singh, V., Sisti, M., Speller, D., Surukuchi, P. T., Taffarello, L., Tellier, O., Tomei, C., Tretyak, V. I., Tsymbaliuk, A., Velazquez, M., Vetter, K. J., Wagaarachchi, S. L., Wang, G., Wang, L., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Xue, M., Yan, L., Yang, J., Yefremenko, V., Yumatov, V., Zarytskyy, M. M., Zhang, J., Zolotarova, A., and Zucchelli, S.
Subjects: Physics - Instrumentation and Detectors
Abstract: Precise characterization of detector time resolution is of crucial importance for next-generation cryogenic-bolometer experiments searching for neutrinoless double-beta decay, such as CUPID, in order to reject background due to pile-up of two-neutrino double-beta decay events. In this paper, we describe a technique developed to study the pile-up rejection capability of cryogenic bolometers. Our approach, which consists of producing controlled pile-up events with a programmable waveform generator, has the benefit that we can reliably and reproducibly control the time separation and relative energy of the individual components of the generated pile-up events. The resulting data allow us to optimize and benchmark analysis strategies to discriminate between individual and pile-up pulses. We describe a test of this technique performed with a small array of detectors at the Laboratori Nazionali del Gran Sasso, in Italy; we obtain a 90% rejection efficiency against pulser-generated pile-up events with rise time of ~15ms down to time separation between the individual events of about 2ms.
Published: 2020
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46. New results from the CUORE experiment

Author: Giachero, A., Adams, D. Q., Alduino, C., Alfonso, K., Avignone III, F. T., Azzolini, O., Bari, G., Bellini, F., Benato, G., Biassoni, M., Branca, A., Brofferio, C., Bucci, C., Camilleri, J., Caminata, A., Campani, A., Canonica, L., Cao, X. G., Capelli, S., Cappelli, L., Cardani, L., Carniti, P., Casali, N., Celi, E., Chiesa, D., Clemenza, M., Copello, S., Cosmelli, C., Cremonesi, O., Creswick, R. J., D'Addabbo, A., Dafinei, I., Davis, C. J., Dell'Oro, S., Di Domizio, S., Dompè, V., Fang, D. Q., Fantini, G., Faverzani, M., Ferri, E., Ferroni, F., Fiorini, E., Franceschi, M. A., Freedman, S. J., Fu, S. H., Fujikawa, B. K., Gironi, L., Giuliani, A., Gorla, P., Gotti, C., Gutierrez, T. D., Han, K., Heeger, K. M., Huang, R. G., Huang, H. Z., Johnston, J., Keppel, G., Kolomensky, Yu. G., Ligi, C., Ma, L., Ma, Y. G., Marini, L., Maruyama, R. H., Mayer, D., Mei, Y., Moggi, N., Morganti, S., Napolitano, T., Nastasi, M., Nikkel, J., Nones, C., Norman, E. B., Nucciotti, A., Nutini, I., O'Donnell, T., Ouellet, J. L., Pagan, S., Pagliarone, C. E., Pagnanini, L., Pallavicini, M., Pattavina, L., Pavan, M., Pessina, G., Pettinacci, V., Pira, C., Pirro, S., Pozzi, S., Previtali, E., Puiu, A., Rosenfeld, C., Rusconi, C., Sakai, M., Sangiorgio, S., Schmidt, B., Scielzo, N. D., Sharma, V., Singh, V., Sisti, M., Speller, D., Surukuch, P. T., Taffarello, L., Terranova, F., Tomei, C., Vetter, K., Vignati, M., Wagaarachchi, S. L., Wang, B. S., Welliver, B., Wilson, J., Wilson, K., Winslow, L. A., Zimmermann, S., and Zucchelli, S.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: The Cryogenic Underground Observatory for Rare Events (CUORE) is the first cryogenic experiment searching for neutrinoless double-beta ($0\nu\beta\beta$) decay that has been able to reach the one-ton scale. The detector, located at the Laboratori Nazionali del Gran Sasso in Italy, consists of an array of 988 TeO$_2$ crystals arranged in a compact cylindrical structure of 19 towers. Following the completion of the detector construction in August 2016, CUORE began its first physics data run in 2017 at a base temperature of about 10 mK. Following multiple optimization campaigns in 2018, CUORE is currently in stable operating mode. In 2019, CUORE released its 2\textsuperscript{nd} result of the search for $0\nu\beta\beta$ with a TeO$_2$ exposure of 372.5 kg$\cdot$yr and a median exclusion sensitivity to a $^{130}$Te $0\nu\beta\beta$ decay half-life of $1.7\cdot 10^{25}$ yr. We find no evidence for $0\nu\beta\beta$ decay and set a 90\% C.I. (credibility interval) Bayesian lower limit of $3.2\cdot 10^{25}$ yr on the $^{130}$Te $0\nu\beta\beta$ decay half-life. In this work, we present the current status of CUORE's search for $0\nu\beta\beta$, as well as review the detector performance. Finally, we give an update of the CUORE background model and the measurement of the $^{130}$Te two neutrino double-beta ($2\nu\beta\beta$) decay half-life., Comment: Proceeding of 40th International Conference on High Energy physics (ICHEP2020), July 28 - August 6, 2020, Prague, Czech Republic (virtual meeting). arXiv admin note: text overlap with arXiv:1905.07667
Published: 2020

47. Novel technique for the study of pileup events in cryogenic bolometers

Author: Armatol, A, Armengaud, E, Armstrong, W, Augier, C, Avignone, FT, Azzolini, O, Barabash, A, Bari, G, Barresi, A, Baudin, D, Bellini, F, Benato, G, Beretta, M, Bergé, L, Biassoni, M, Billard, J, Boldrini, V, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Cazes, A, Celi, E, Chang, C, Chapellier, M, Charrier, A, Chiesa, D, Clemenza, M, Colantoni, I, Collamati, F, Copello, S, Cremonesi, O, Creswick, RJ, Cruciani, A, D'Addabbo, A, D'Imperio, G, Dafinei, I, Danevich, FA, de Combarieu, M, De Jesus, M, de Marcillac, P, Dell'Oro, S, Di Domizio, S, Dompè, V, Drobizhev, A, Dumoulin, L, Fantini, G, Faverzani, M, Ferri, E, Ferri, F, Ferroni, F, Figueroa-Feliciano, E, Formaggio, J, Franceschi, A, Fu, C, Fu, S, Fujikawa, BK, Gascon, J, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gras, P, Gros, M, Gutierrez, TD, Han, K, Hansen, EV, Heeger, KM, Helis, DL, Huang, HZ, Huang, RG, Imbert, L, Johnston, J, Juillard, A, Karapetrov, G, Keppel, G, Khalife, H, Kobychev, VV, Kolomensky, Yu G, Konovalov, S, Liu, Y, Loaiza, P, Ma, L, Madhukuttan, M, Mancarella, F, Mariam, R, Marini, L, Marnieros, S, Martinez, M, Maruyama, RH, Mauri, B, Mayer, D, Mei, Y, and Milana, S
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Nuclear and plasma physics
Abstract: Precise characterization of detector time resolution is of crucial importance for next-generation cryogenic-bolometer experiments searching for neutrinoless double-beta decay, such as CUPID, in order to reject background due to pileup of two-neutrino double-beta decay events. In this paper, we describe a technique developed to study the pileup rejection capability of cryogenic bolometers. Our approach, which consists of producing controlled pileup events with a programmable wave-form generator, has the benefit that we can reliably and reproducibly control the time separation and relative energy of the individual components of the generated pileup events. The resulting data allow us to optimize and benchmark analysis strategies to discriminate between individual and pileup pulses. We describe a test of this technique performed with a small array of detectors at the Laboratori Nazionali del Gran Sasso, in Italy; we obtain a 90% rejection efficiency against pulser-generated pileup events with rise time of ∼15ms down to time separation between the individual events of about 2ms.
Published: 2021

48. Search for double-beta decay of 130Te to the 0+ states of 130Xe with CUORE

Author: Adams, DQ, Alduino, C, Alfonso, K, Avignone, FT III, Azzolini, O, Bari, G, Bellini, F, Benato, G, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cosmelli, C, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Davis, CJ, Dell’Oro, S, Domizio, S Di, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, Yu G, Ligi, C, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moggi, N, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O’Donnell, T, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Rosenfeld, C, Rusconi, C, Sakai, M, Sangiorgio, S, Schmidt, B, Scielzo, ND, Sharma, V, Singh, V, Sisti, M, Speller, D, and Surukuchi, PT
Subjects: Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Astronomical sciences, Atomic, molecular and optical physics, Particle and high energy physics
Abstract: The CUORE experiment is a large bolometric array searching for the lepton number violating neutrino-less double beta decay (0 νββ) in the isotope 130Te. In this work we present the latest results on two searches for the double beta decay (DBD) of 130Te to the first 02+ excited state of 130Xe : the 0 νββ decay and the Standard Model-allowed two-neutrinos double beta decay (2 νββ). Both searches are based on a 372.5 kg× yr TeO2 exposure. The de-excitation gamma rays emitted by the excited Xe nucleus in the final state yield a unique signature, which can be searched for with low background by studying coincident events in two or more bolometers. The closely packed arrangement of the CUORE crystals constitutes a significant advantage in this regard. The median limit setting sensitivities at 90% Credible Interval (C.I.) of the given searches were estimated as S1/20ν=5.6×1024yr for the 0 νββ decay and S1/22ν=2.1×1024yr for the 2 νββ decay. No significant evidence for either of the decay modes was observed and a Bayesian lower bound at 90 % C.I. on the decay half lives is obtained as: (T1/2)02+0ν>5.9×1024yr for the 0 νββ mode and (T1/2)02+2ν>1.3×1024yr for the 2 νββ mode. These represent the most stringent limits on the DBD of 130Te to excited states and improve by a factor ∼ 5 the previous results on this process.
Published: 2021

49. Search for double-beta decay of 130Te to the 0 + states of 130Xe with CUORE

Author: Adams, DQ, Alduino, C, Alfonso, K, Avignone, FTI, Azzolini, O, Bari, G, Bellini, F, Benato, G, Biassoni, M, Branca, A, Brofferio, C, Bucci, C, Camilleri, J, Caminata, A, Campani, A, Canonica, L, Cao, XG, Capelli, S, Cappelli, L, Cardani, L, Carniti, P, Casali, N, Celi, E, Chiesa, D, Clemenza, M, Copello, S, Cosmelli, C, Cremonesi, O, Creswick, RJ, D’Addabbo, A, Dafinei, I, Davis, CJ, Dell’Oro, S, Domizio, SD, Dompè, V, Fang, DQ, Fantini, G, Faverzani, M, Ferri, E, Ferroni, F, Fiorini, E, Franceschi, MA, Freedman, SJ, Fu, SH, Fujikawa, BK, Giachero, A, Gironi, L, Giuliani, A, Gorla, P, Gotti, C, Gutierrez, TD, Han, K, Heeger, KM, Huang, RG, Huang, HZ, Johnston, J, Keppel, G, Kolomensky, YG, Ligi, C, Ma, L, Ma, YG, Marini, L, Maruyama, RH, Mayer, D, Mei, Y, Moggi, N, Morganti, S, Napolitano, T, Nastasi, M, Nikkel, J, Nones, C, Norman, EB, Nucciotti, A, Nutini, I, O’Donnell, T, Ouellet, JL, Pagan, S, Pagliarone, CE, Pagnanini, L, Pallavicini, M, Pattavina, L, Pavan, M, Pessina, G, Pettinacci, V, Pira, C, Pirro, S, Pozzi, S, Previtali, E, Puiu, A, Rosenfeld, C, Rusconi, C, Sakai, M, Sangiorgio, S, Schmidt, B, Scielzo, ND, Sharma, V, Singh, V, Sisti, M, Speller, D, and Surukuchi, PT
Subjects: Nuclear & Particles Physics, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics
Abstract: The CUORE experiment is a large bolometric array searching for the lepton number violating neutrino-less double beta decay (0 νββ) in the isotope 130Te. In this work we present the latest results on two searches for the double beta decay (DBD) of 130Te to the first 02+ excited state of 130Xe : the 0 νββ decay and the Standard Model-allowed two-neutrinos double beta decay (2 νββ). Both searches are based on a 372.5 kg× yr TeO2 exposure. The de-excitation gamma rays emitted by the excited Xe nucleus in the final state yield a unique signature, which can be searched for with low background by studying coincident events in two or more bolometers. The closely packed arrangement of the CUORE crystals constitutes a significant advantage in this regard. The median limit setting sensitivities at 90% Credible Interval (C.I.) of the given searches were estimated as S1/20ν=5.6×1024yr for the 0 νββ decay and S1/22ν=2.1×1024yr for the 2 νββ decay. No significant evidence for either of the decay modes was observed and a Bayesian lower bound at 90 % C.I. on the decay half lives is obtained as: (T1/2)02+0ν>5.9×1024yr for the 0 νββ mode and (T1/2)02+2ν>1.3×1024yr for the 2 νββ mode. These represent the most stringent limits on the DBD of 130Te to excited states and improve by a factor ∼ 5 the previous results on this process.
Published: 2021

50. Psoriasis and Leprosy: An Arcane Relationship

Author: Ge G, Shang J, Gan T, Chen Z, Pan C, Mei Y, Long S, Wu A, and Wang H
Subjects: psoriasis, leprosy, th17 cell, macrophage, il-17a, clec4e, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract: Gai Ge,1 Jingzhe Shang,2,3 Tian Gan,1 Zhiming Chen,1 Chun Pan,1 Youming Mei,1 Siyu Long,4 Aiping Wu,2,3 Hongsheng Wang1,5,6 1Laboratory of Mycobacteria, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, People’s Republic of China; 2Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China; 3Suzhou Institute of Systems Medicine, Suzhou, People’s Republic of China; 4Department of Dermatology, Beijing Chao-Yang Hospital & Capital Medical University, Beijing, People’s Republic of China; 5National Center for Sexually Transmitted Disease and Leprosy Control, China Centers for Disease Control and Prevention, Nanjing, People’s Republic of China; 6Centre for Global Health, School of Public Health, Nanjing Medical University, Nanjing, People’s Republic of ChinaCorrespondence: Hongsheng Wang, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 12 Jiang-wang-miao Street, Nanjing, Jiangsu Province, People’s Republic of China, Tel/Fax +86 258 5478953, Email whs33@vip.sina.comPurpose: Psoriasis (Ps) and leprosy are chronic inflammatory skin disorders, characterised by enhanced innate and adaptive immunity. Ps and leprosy rarely coexist. The molecular immune mechanism of the Ps and leprosy rarely coexistence is unclear.Patients and Methods: RNA-sequencing (RNA-seq) was performed on 20 patients with Ps, 5 adults with lepromatous leprosy (L-lep), and 5 patients with tuberculoid leprosy (T-lep) to analyse the differentially expressed genes (DEGs) between them. Moreover, the biological mechanism of Ps and leprosy was explored by Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Gene Ontology (GO) analysis, Gene Set Enrichment Analysis analysis, and protein–protein interaction (PPI) analyses. Finally, 13 DEGs of 10 skin biopsies of Ps patients, 6 samples of L-lep patients, 6 samples of T-lep patients and 5 healthy controls were confirmed by quantitative real-time polymerase chain reaction (qRT-PCR).Results: The PPI network was constructed and primarily associated with immune response, IL-17 signalling, and Toll-like receptor pathway between Ps and leprosy. Th17 markers (interleukin (IL)- 19, IL-20, IL-36A, IL-36G, IL-22, IL-17A, and lipocalin-2 (LCN2) had higher expression in Ps than in L-lep and T-lep, whereas macrophage biomarkers (CLEC4E and TREM2), SPP1, and dendritic cell (DC)-related hallmarks (ITGAX) and TNF-a had significantly lower expression across Ps and T-lep than in L-lep.Conclusion: To put it simply, Ps patients with IL-17A, IL-19, IL-20, IL-36A, IL-36G, and IL-22 in conjunction with LCN2 with up-graduated expression might be not susceptible to L-lep. However, high levels of CLEC4E, TREM2, and SPP1 in L-lep patients indicated that they unlikely suffered from Ps.Keywords: psoriasis, leprosy, Th17 cell, macrophage, IL-17A, CLEC4E
Published: 2023

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