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166 results on '"Mei, Federico"'

5. Chest Tubes and Pleural Drainage: History and Current Status in Pleural Disease Management.

Author

Sorino, Claudio, Feller-Kopman, David, Mei, Federico, Mondoni, Michele, Agati, Sergio, Marchetti, Giampietro, and Rahman, Najib M.

Subjects
MEDICAL personnel, TECHNOLOGICAL innovations, CHEST tubes, DIGITAL technology, MEDICAL drainage, THORACOSTOMY, PNEUMOTHORAX, PLEURA diseases
Abstract

Thoracostomy and chest tube placement are key procedures in treating pleural diseases involving the accumulation of fluids (e.g., malignant effusions, serous fluid, pus, or blood) or air (pneumothorax) in the pleural cavity. Initially described by Hippocrates and refined through the centuries, chest drainage achieved a historical milestone in the 19th century with the creation of closed drainage systems to prevent the entry of air into the pleural space and reduce infection risk. The introduction of plastic materials and the Heimlich valve further revolutionized chest tube design and function. Technological advancements led to the availability of various chest tube designs (straight, angled, and pig-tail) and drainage systems, including PVC and silicone tubes with radiopaque stripes for better radiological visualization. Modern chest drainage units can incorporate smart digital systems that monitor and graphically report pleural pressure and evacuated fluid/air, improving patient outcomes. Suction application via wall systems or portable digital devices enhances drainage efficacy, although careful regulation is needed to avoid complications such as re-expansion pulmonary edema or prolonged air leak. To prevent recurrent effusion, particularly due to malignancy, pleurodesis agents can be applied through the chest tube. In cases of non-expandable lung, maintaining a long-term chest drain may be the most appropriate approach and procedures such as the placement of an indwelling pleural catheter can significantly improve quality of life. Continued innovations and rigorous training ensure that chest tube insertion remains a cornerstone of effective pleural disease management. This review provides a comprehensive overview of the historical evolution and modern advancements in pleural drainage. By addressing both current technologies and procedural outcomes, it serves as a valuable resource for healthcare professionals aiming to optimize pleural disease management and patient care. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Endoscopic view of intrapleural foreign body: fragment of catheter for extemporaneous cardiac pacing.

Author

Fantin, Alberto, additional, Castaldo, Nadia, additional, Palou, Michelangelo Schwartzbaum, additional, Viterale, Giovanni, additional, Crisafulli, Ernesto, additional, Sartori, Giulia, additional, Patrucco, Filippo, additional, Vailati, Paolo, additional, Morana, Giuseppe, additional, Mei, Federico, additional, Zuccatosta, Lina, additional, and Patruno, Vincenzo, additional

Published
2024
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8. Beyond diagnosis: a narrative review of the evolving therapeutic role of medical thoracoscopy in the management of pleural diseases

Author

Fantin, Alberto, primary, Castaldo, Nadia, additional, Palou, Michelangelo Schwartzbaum, additional, Viterale, Giovanni, additional, Crisafulli, Ernesto, additional, Sartori, Giulia, additional, Patrucco, Filippo, additional, Vailati, Paolo, additional, Morana, Giuseppe, additional, Mei, Federico, additional, Zuccatosta, Lina, additional, and Patruno, Vincenzo, additional

Published
2024
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11. Understanding Patterns of Adherence to Antifibrotic Treatment in Idiopathic Pulmonary Fibrosis: Insights from an Italian Prospective Cohort Study.

Author

Iommi, Marica, Gonnelli, Francesca, Bonifazi, Martina, Faragalli, Andrea, Mei, Federico, Pompili, Marco, Carle, Flavia, and Gesuita, Rosaria

Subjects
PATIENT compliance, COHORT analysis, DISEASE exacerbation, LONGITUDINAL method, SEQUENCE analysis, IDIOPATHIC pulmonary fibrosis
Abstract

Background: Pirfenidone and Nintedanib have significantly improved the prognosis of patients with idiopathic pulmonary fibrosis (IPF), reducing mortality risk and exacerbations. This study aimed to analyze antifibrotic treatment utilization and its association with clinical outcomes (i.e., acute exacerbation or death) during 2014–2021 in newly diagnosed IPF patients, using Healthcare Utilization Databases of the Marche Region, Italy. Methods: The first 12-month adherence to antifibrotic was estimated using the Proportion of Days Covered (PDC), defining adherence as PDC ≥ 75%. State Sequence Analysis over the initial 52 weeks of treatment was used to identify adherence patterns. The role of adherence patterns on acute exacerbations/death, adjusted by demographic, clinical features, and monthly adherence after the 52-week period (time-dependent variable), was assessed with Cox regression. Results: Among 667 new IPF cases, 296 received antifibrotic prescriptions, with 62.8% being adherent in the first year. Three antifibrotic utilization patterns emerged—high adherence (37.2%), medium adherence (42.5%), and low adherence (20.3%)—with median PDCs of 95.3%, 79.5%, and 18.6%, respectively. These patterns did not directly influence three-year mortality/exacerbation probability, but sustained adherence reduced risk over time. Conclusions: Good adherence was observed in in this population-based study, emphasizing the importance of continuous antifibrotics therapy over time to mitigate adverse outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Patient-derived organoids of malignant pleural mesothelioma

Author

Gonnelli, Francesca, primary, Volpini, Luca, additional, Monaco, Federica, additional, Tomasetti, Marco, additional, Barbisan, Francesca, additional, Goteri, Gaia, additional, Santarelli, Lory, additional, Zuccatosta, Lina, additional, and Mei, Federico, additional

Published
2023
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17. Treatment and clinical outcomes in pleural infection: preliminary results from a multi-centre study

Author

Fattori, Chiara, primary, Piergentili, Luca, additional, Bonifazi, Martina, additional, Barbisan, Francesca, additional, Goteri, Gaia, additional, Zuccatosta, Lina, additional, Di Marco Berardino, Alessandro, additional, Sediari, Michele, additional, Gonnelli, Francesca, additional, Cirilli, Laura, additional, Porcarelli, Francesco Maria, additional, Balbo, Piero Emilio, additional, Paracchini, Elena, additional, Carpagnano, Giovanna Elisiana, additional, Gasparini, Stefano, additional, Marchetti, Giampietro, additional, and Mei, Federico, additional

Published
2023
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19. Clinical characteristics of chylothorax: results from the International Collaborative Effusion database

Author

Porcel, José M., primary, Bielsa, Silvia, additional, Civit, Carmen, additional, Aujayeb, Avinash, additional, Janssen, Julius, additional, Bodtger, Uffe, additional, Fjaellegaard, Katrine, additional, Petersen, Jesper Koefod, additional, Welch, Hugh, additional, Symonds, Jenny, additional, Mitchell, Michael A., additional, Grabczak, Elżbieta Magdalena, additional, Ellayeh, Mohamed, additional, Addala, Dinesh, additional, Wrightson, John M., additional, Rahman, Najib M., additional, Munavvar, Mohammed, additional, Koegelenberg, Coenraad F.N., additional, Labarca, Gonzalo, additional, Mei, Federico, additional, Maskell, Nick, additional, and Bhatnagar, Rahul, additional

Published
2023
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20. Clinical characteristics of chylothorax: results from the International Collaborative Effusion database

Author

Porcel, José M, Bielsa, Silvia, Civit, Carmen, Aujayeb, Avinash, Janssen, Julius, Bodtger, Uffe, Fjaellegaard, Katrine, Petersen, Jesper Koefod, Welch, Hugh, Symonds, Jenny, Mitchell, Michael A, Grabczak, Elżbieta Magdalena, Ellayeh, Mohamed, Addala, Dinesh, Wrightson, John M, Rahman, Najib M, Munavvar, Mohammed, Koegelenberg, Coenraad F N, Labarca, Gonzalo, Mei, Federico, Maskell, Nick, Bhatnagar, Rahul, Porcel, José M, Bielsa, Silvia, Civit, Carmen, Aujayeb, Avinash, Janssen, Julius, Bodtger, Uffe, Fjaellegaard, Katrine, Petersen, Jesper Koefod, Welch, Hugh, Symonds, Jenny, Mitchell, Michael A, Grabczak, Elżbieta Magdalena, Ellayeh, Mohamed, Addala, Dinesh, Wrightson, John M, Rahman, Najib M, Munavvar, Mohammed, Koegelenberg, Coenraad F N, Labarca, Gonzalo, Mei, Federico, Maskell, Nick, and Bhatnagar, Rahul

Abstract

BackgroundChylothorax is an uncommon medical condition for which limited data are available regarding the contemporary aetiology, management and outcomes. The goal of this study was to better define these poorly characterised features.MethodsThe medical records of adult patients diagnosed with chylothorax at 12 centres across Europe, America and South Africa from 2009-2021 were retrospectively reviewed. Descriptive and inferential statistics were performed.Results77 patients (median age 69 years, male to female ratio 1.5) were included. Subacute dyspnoea was the most typical presenting symptom (66%). The commonest cause of chylothorax was malignancy (68.8%), with lymphoma accounting for 62% of these cases. Other aetiologies were trauma (13%), inflammatory/miscellaneous conditions (11.7%) and idiopathic cases (6.5%). At the initial thoracentesis, the pleural fluid appeared milky in 73%, was exudative in 89% and exhibited triglyceride concentrations >100 mg·dL-1 in 88%. Lymphangiography/lymphoscintigraphy were rarely ordered (3%), and demonstration of chylomicrons in pleural fluid was never ascertained. 67% of patients required interventional pleural procedures. Dietary measures were infrequently followed (36%). No patient underwent thoracic duct ligation or embolisation. Morbidity included infections (18%), and thrombosis in malignant aetiologies (16%). The 1-year mortality was 47%. Pleural fluid protein >3.5 mg·dL-1 (sub-distribution hazard ratio (SHR) 4.346) or lactate dehydrogenase -1 (SHR 10.21) increased the likelihood of effusion resolution. Pleural fluid protein ≤3.5 mg·dL-1 (HR 4.047), bilateral effusions (HR 2.749) and a history of respiratory disease (HR 2.428) negatively influenced survival.ConclusionChylothoraces have a poor prognosis and most require pleural interventions. Despite the standard recommendations, lymphatic imaging is seldom used, nor are dietary restrictions followed.

Published
2023

21. Investigation and outcomes in patients with non-specific pleuritis: Results from the International Collaborative Effusion (ICE) database

Author

Sundaralingam, Anand, primary, Aujayeb, Avinash, additional, Jackson, Karl A., additional, Pellas, Emilia I., additional, Khan, Irfan I., additional, Chohan, Muhammad T., additional, Joosten, Roos, additional, Boersma, Anton, additional, Kerkhoff, Jordy, additional, Bielsa, Silvia, additional, Porcel, Jose M., additional, Rozman, Ales, additional, Marc-Malovrh, Mateja, additional, Welch, Hugh, additional, Symonds, Jenny, additional, Anevlavis, Stavros, additional, Froudrakis, Marios, additional, Mei, Federico, additional, Zuccatosta, Lina, additional, Gasparini, Stefano, additional, Gonnelli, Francesca, additional, Dhaliwal, Inderdeep, additional, Mitchell, Michael A., additional, Fjaellegaard, Katrine, additional, Petersen, Jesper K., additional, Ellayeh, Mohamed, additional, Rahman, Najib M., additional, Burden, Tom, additional, Bodtger, Uffe, additional, Koegelenberg, Coenraad F.N., additional, Maskell, Nick A., additional, Janssen, Julius, additional, and Bhatnagar, Rahul, additional

Published
2023
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24. Additional file 2 of Effectiveness and economic impact of Dupilumab in asthma: a population-based cohort study

Author

Faverio, Paola, Ronco, Raffaella, Monzio Compagnoni, Matteo, Franchi, Matteo, Franco, Giovanni, Bonaiti, Giulia, Bonifazi, Martina, Mei, Federico, Luppi, Fabrizio, Pesci, Alberto, and Corrao, Giovanni

Abstract

Additional file 2: Table S1. Diagnostic and therapeutic (ICD-9-CM and ATC) codes used in the current study for drawing records and fields from Healthcare Utilization databases. Lombardy, Italy, 2020–2021. Table S2. Use of specific healthcare services during the 6 months after the matching date (follow-up period), during the corresponding 6 months of the prior year (baseline period) and during the 6 months preceding the matching date (wash-out period) among subjects who did not use Dupilumab and were 1:1 matched to those who used it.

Published
2023
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27. Validation of a Cytological Classification System for the Rapid On-Site Evaluation (Rose) of Pulmonary and Mediastinal Needle Aspirates

Author

Zuccatosta, Lina, primary, Rossi, Giulio, additional, Gasparini, Stefano, additional, Ferretti, Maurizio, additional, Mei, Federico, additional, Sediari, Michele, additional, Barbisan, Francesca, additional, Goteri, Gaia, additional, Corbo, Giuseppe Maria, additional, and Di Marco Berardino, Alessandro, additional

Published
2022
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28. Economic impact of anti-IL-5 agents in patients with severe eosinophilic asthma: A population-based cohort study

Author

Faverio, Paola, primary, Monzio Compagnoni, Matteo, additional, Ronco, Raffaella, additional, Franchi, Matteo, additional, Della Zoppa, Matteo, additional, Bonaiti, Giulia, additional, Bonifazi, Martina, additional, Mei, Federico, additional, Luppi, Fabrizio, additional, Pesci, Alberto, additional, and Corrao, Giovanni, additional

Published
2022
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31. Diagnostic Role of Bronchoalveolar Lavage in Patients with Suspected SARS-CoV-2 Pneumonia and Negative Upper Respiratory Tract Swab: A Systematic Review and Meta-Analysis

Author

Mei, Federico, primary, Rota, Matteo, additional, Bonifazi, Martina, additional, Zuccatosta, Lina, additional, Porcarelli, Francesco, additional, Sediari, Michele, additional, Gonnelli, Francesca, additional, Di Marco Berardino, Alessandro, additional, and Gasparini, Stefano, additional

Published
2022
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33. Economic impact of anti-IL-5 agents in patients with severe eosinophilic asthma: A population-based cohort study

Author

Faverio, P, Monzio Compagnoni, M, Ronco, R, Franchi, M, Della Zoppa, M, Bonaiti, G, Bonifazi, M, Mei, F, Luppi, F, Pesci, A, Corrao, G, Faverio, Paola, Monzio Compagnoni, Matteo, Ronco, Raffaella, Franchi, Matteo, Della Zoppa, Matteo, Bonaiti, Giulia, Bonifazi, Martina, Mei, Federico, Luppi, Fabrizio, Pesci, Alberto, Corrao, Giovanni, Faverio, P, Monzio Compagnoni, M, Ronco, R, Franchi, M, Della Zoppa, M, Bonaiti, G, Bonifazi, M, Mei, F, Luppi, F, Pesci, A, Corrao, G, Faverio, Paola, Monzio Compagnoni, Matteo, Ronco, Raffaella, Franchi, Matteo, Della Zoppa, Matteo, Bonaiti, Giulia, Bonifazi, Martina, Mei, Federico, Luppi, Fabrizio, Pesci, Alberto, and Corrao, Giovanni

Published
2022

34. Accuracy and Predictors of Success of EUS-B-FNA in the Diagnosis of Pulmonary Malignant Lesions: A Prospective Multicenter Italian Study

Author

Mondoni, Michele, Gasparini, Stefano, Varone, Francesco, Trisolini, Rocco, Mancino, Laura, Rossi, Giulio, Carlucci, Paolo, Bonifazi, Martina, Mei, Federico, Zuccatosta, Lina, Michieletto, Lucio, Pitari, Federica, Saderi, Laura, Richeldi, Luca, Centanni, Stefano, Sotgiu, Giovanni, Richeldi, Luca (ORCID:0000-0001-8594-1448), Mondoni, Michele, Gasparini, Stefano, Varone, Francesco, Trisolini, Rocco, Mancino, Laura, Rossi, Giulio, Carlucci, Paolo, Bonifazi, Martina, Mei, Federico, Zuccatosta, Lina, Michieletto, Lucio, Pitari, Federica, Saderi, Laura, Richeldi, Luca, Centanni, Stefano, Sotgiu, Giovanni, and Richeldi, Luca (ORCID:0000-0001-8594-1448)

Abstract

Background: The role of endoscopic ultrasound with bronchoscope fine-needle aspiration (EUS-B-FNA) in the diagnosis of suspected malignant pulmonary lesions adjacent to the esophagus has been poorly investigated. The aim of the present study was to assess the accuracy of EUS-B-FNA for the diagnosis and molecular profiling of paraesophageal pulmonary lesions, as well as its predictors of success. Materials and Methods: Patients who underwent EUS-B-FNA for the diagnosis of paraesophageal lesions were consecutively enrolled in four Italian centers. Demographic, clinical, procedural, pathological, and molecular characteristics of the malignant samples were collected. The primary outcome was the diagnostic accuracy for pulmonary malignancies. Secondary outcomes were diagnostic yield and predictors of success for diagnosis and molecular profiling. Results: 107 adult patients (60 [56.1%] males; median (interquartile range) age: 69 [60–70] years) were enrolled. The diagnostic accuracy of EUS-B-FNA was 95.3% in the overall cohort and 95.2% in the 99 patients with a final diagnosis of malignancy. Neither clinical nor procedural variables significantly affected the diagnostic accuracy, whereas rapid on-site evaluation (ROSE), performed by pathologists or trained pulmonologists, was a strong predictor for a complete molecular profiling (OR [95% CI]: 12.9 [1.2–137.4]; p value: 0.03). Conclusion: EUS-B-FNA is a safe and accurate method for the diagnosis of paraesophageal pulmonary lesions. The presence of ROSE is relevant for a complete molecular profiling in this selected cohort of patients with advanced lung cancer.

Published
2022

36. Accuracy and Predictors of Success of EUS-B-FNA in the Diagnosis of Pulmonary Malignant Lesions: A Prospective Multicenter Italian Study

Author

Mondoni, Michele, primary, Gasparini, Stefano, additional, Varone, Francesco, additional, Trisolini, Rocco, additional, Mancino, Laura, additional, Rossi, Giulio, additional, Carlucci, Paolo, additional, Bonifazi, Martina, additional, Mei, Federico, additional, Zuccatosta, Lina, additional, Michieletto, Lucio, additional, Pitari, Federica, additional, Saderi, Laura, additional, Richeldi, Luca, additional, Centanni, Stefano, additional, and Sotgiu, Giovanni, additional

Published
2022
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39. Predictors of worse prognosis in young adults hospitalized with COVID-19 pneumonia: a multi-center Italian study (COVID-UNDER50)

Author

Bonifazi, Martina, primary, Mei, Federico, additional, Skrami, Edlira, additional, Carle, Flavia, additional, Gasparini, Stefano, additional, Zuccatosta, Lina, additional, Di Marco Berardino, Alessandro, additional, Amico, Donatella, additional, Balestro, Elisabetta, additional, Bini, Francesco, additional, Candoli, Piero, additional, Caminati, Antonella, additional, Harari, Sergio, additional, Marchetti, Giampietro, additional, Levi, Guido, additional, Piciucchi, Sara, additional, Poletti, Venerino, additional, Ravaglia, Claudia, additional, Lococo, Sara, additional, Saetta, Marina, additional, Tomassetti, Sara, additional, Tamburrini, Mario, additional, Zuccon, Umberto, additional, Zanforlin, Alessandro, additional, and Menditto, Vincenzo, additional

Published
2021
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44. Pleuroparenchymal fibroelastosis in systemic sclerosis: prevalence and prognostic impact

Author

Bonifazi, Martina, Sverzellati, Nicola, Negri, Eva, Jacob, Joseph, Egashira, Ryoko, Moser, Joanna, Piciucchi, Sara, Mei, Federico, De Lauretis, Angelo, Visca, Dina, Goh, Nicole, Bonini, Matteo, Cirilli, Laura, La Vecchia, Carlo, Chua, Felix, Kouranos, Vasileio, Margaritopoulos, George, Kokosi, Maria, Maher, Toby M, Gasparini, Stefano, Gabrielli, Armando, Wells, Athol U, Renzoni, Elisabetta A, Bonini, Matteo (ORCID:0000-0002-3042-0765), Bonifazi, Martina, Sverzellati, Nicola, Negri, Eva, Jacob, Joseph, Egashira, Ryoko, Moser, Joanna, Piciucchi, Sara, Mei, Federico, De Lauretis, Angelo, Visca, Dina, Goh, Nicole, Bonini, Matteo, Cirilli, Laura, La Vecchia, Carlo, Chua, Felix, Kouranos, Vasileio, Margaritopoulos, George, Kokosi, Maria, Maher, Toby M, Gasparini, Stefano, Gabrielli, Armando, Wells, Athol U, Renzoni, Elisabetta A, and Bonini, Matteo (ORCID:0000-0002-3042-0765)

Published
2020

45. Predictors of Worse Prognosis in Young and Middle-Aged Adults Hospitalized with COVID-19 Pneumonia: A Multi-Center Italian Study (COVID-UNDER50)

Author

Bonifazi, Martina, primary, Mei, Federico, additional, Skrami, Edlira, additional, Latini, Lara Letizia, additional, Amico, Donatella, additional, Balestro, Elisabetta, additional, Bini, Francesco, additional, Bonifazi, Floriano, additional, Caminati, Antonella, additional, Candoli, Piero, additional, Cinti, Saverio, additional, Contucci, Susanna, additional, Di Marco Berardino, Alessandro, additional, Harari, Sergio, additional, Levi, Guido, additional, Lococo, Sara, additional, Menditto, Vincenzo, additional, Marchetti, Giampietro, additional, Piciucchi, Sara, additional, Poletti, Venerino, additional, Ravaglia, Claudia, additional, Saetta, Marina, additional, Svegliati-Baroni, Gianluca, additional, Tomassetti, Sara, additional, Tamburrini, Mario, additional, Zanforlin, Alessandro, additional, Zuccon, Umberto, additional, Zuccatosta, Lina, additional, Gasparini, Stefano, additional, and Carle, Flavia, additional

Published
2021
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49. First Detection of SARS-CoV-2 by Real-Time Reverse Transcriptase-Polymerase Chain Reaction Assay in Pleural Fluid

Author

Mei, Federico, primary, Bonifazi, Martina, additional, Menzo, Stefano, additional, Di Marco Berardino, Alessandro, additional, Sediari, Michele, additional, Paolini, Luca, additional, Re, Antonina, additional, Gonnelli, Francesca, additional, Duranti, Claudia, additional, Grilli, Martina, additional, Vennarucci, Giacomo Spurio, additional, Latini, Maria Agnese, additional, Zuccatosta, Lina, additional, and Gasparini, Stefano, additional

Published
2020
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50. Pleuroparenchymal fibroelastosis in systemic sclerosis: prevalence and prognostic impact

Author

Bonifazi, Martina, primary, Sverzellati, Nicola, additional, Negri, Eva, additional, Jacob, Joseph, additional, Egashira, Ryoko, additional, Piciucchi, Sara, additional, Mei, Federico, additional, De Lauretis, Angelo, additional, Visca, Dina, additional, Goh, Nicole, additional, Bonini, Matteo, additional, La Vecchia, Carlo, additional, Chua, Felix, additional, Kouranos, Vasileios, additional, Margaritopoulos, George, additional, Kokosi, Maria, additional, Maher, Toby M, additional, Gasparini, Stefano, additional, Gabrielli, Armando, additional, Wells, Athol U, additional, and Renzoni, Elisabetta, additional

Published
2020
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