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2. Neurological disorders

Author

Manji, Hadi, primary, Connolly, Seán, additional, Kitchen, Neil, additional, Lambery, Christian, additional, and Mehta, Amrish, additional

Published
2018
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3. Neuroradiology

Author

Manji, Hadi, primary, Connolly, Seán, additional, Kitchen, Neil, additional, Lambery, Christian, additional, Mehta, Amrish, additional, and Sheikh, Faraz Tariq, additional

Published
2018
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5. Kisspeptin modulates sexual and emotional brain processing in humans

Author

Comninos, Alexander N., Wall, Matthew B., Demetriou, Lysia, Shah, Amar J., Clarke, Sophie A., Narayanaswamy, Shakunthala, Nesbitt, Alexander, Izzi-Engbeaya, Chioma, Prague, Julia K., Abbara, Ali, Ratnasabapathy, Risheka, Salem, Victoria, Nijher, Gurjinder M., Jayasena, Channa N., Tanner, Mark, Bassett, Paul, Mehta, Amrish, Rabiner, Eugenii A., Honigsperger, Christoph, Silva, Meire Ribeiro, Brandtzaeg, Ole Kristian, Lundanes, Elsa, Wilson, Steven Ray, Brown, Rachel C., Thomas, Sarah A., Bloom, Stephen R., and Dhillo, Waljit S.

Subjects
Observations, Genetic aspects, Properties, Sexual behavior -- Genetic aspects, Limbic system -- Observations, Neuropeptides -- Properties, Brain research, Sex -- Genetic aspects
Abstract

Introduction Unraveling the intrinsic links among sex, emotion, and reproduction relies on a focused exploration of putative factors. Identifying a factor that unites these fundamental components of human behavior has [...], BACKGROUND. Sex, emotion, and reproduction are fundamental and tightly entwined aspects of human behavior. At a population level in humans, both the desire for sexual stimulation and the desire to bond with a partner are important precursors to reproduction. However, the relationships between these processes are incompletely understood. The limbic brain system has key roles in sexual and emotional behaviors, and is a likely candidate system for the integration of behavior with the hormonal reproductive axis. We investigated the effects of kisspeptin, a recently identified key reproductive hormone, on limbic brain activity and behavior. METHODS. Using a combination of functional neuroimaging and hormonal and psychometric analyses, we compared the effects of kisspeptin versus vehicle administration in 29 healthy heterosexual young men. RESULTS. We demonstrated that kisspeptin administration enhanced limbic brain activity specifically in response to sexual and couple-bonding stimuli. Furthermore, kisspeptin's enhancement of limbic brain structures correlated with psychometric measures of reward, drive, mood, and sexual aversion, providing functional significance. In addition, kisspeptin administration attenuated negative mood. CONCLUSIONS. Collectively, our data provide evidence of an undescribed role for kisspeptin in integrating sexual and emotional brain processing with reproduction in humans. These results have important implications for our understanding of reproductive biology and are highly relevant to the current pharmacological development of kisspeptin as a potential therapeutic agent for patients with common disorders of reproductive function. FUNDING. National Institute for Health Research (NIHR), Wellcome Trust (Ref 080268), and the Medical Research Council (MRC).

Published
2017
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12. Neuroradiology

Author

Manji, Hadi, primary, Connolly, Seán, additional, Kitchen, Neil, additional, Lambert, Christian, additional, and Mehta, Amrish, additional

Published
2014
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13. Clinical neurophysiology

Author

Manji, Hadi, primary, Connolly, Seán, additional, Kitchen, Neil, additional, Lambery, Christian, additional, and Mehta, Amrish, additional

Published
2014
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15. Neurological emergencies

Author

Manji, Hadi, primary, Connolly, Seán, additional, Kitchen, Neil, additional, Lambery, Christian, additional, and Mehta, Amrish, additional

Published
2014
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18. Neurological disorders

Author

Manji, Hadi, primary, Connolly, Seán, additional, Kitchen, Neil, additional, Lambert, Christian, additional, and Mehta, Amrish, additional

Published
2014
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19. Neurology in medicine

Author

Manji, Hadi, primary, Connolly, Seán, additional, Kitchen, Neil, additional, Lambery, Christian, additional, and Mehta, Amrish, additional

Published
2014
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26. Oxford Handbook of Neurology

Author

Manji, Hadi, primary, Wills, Adrian, additional, Kitchen, Neil, additional, Dorward, Neil, additional, Connelly, Sean, additional, and Mehta, Amrish, additional

Published
2010
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29. Chapter 7 Neuroradiology

Author

Manji, Hadi, primary, Connolly, Sean, additional, Dorward, Neil, additional, Kitchen, Neil, additional, Mehta, Amrish, additional, and Wills, Adrian, additional

Published
2007
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30. Chapter 4 Neurological disorders

Author

Manji, Hadi, primary, Connolly, Sean, additional, Dorward, Neil, additional, Kitchen, Neil, additional, Mehta, Amrish, additional, and Wills, Adrian, additional

Published
2007
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31. Chapter 2 Neuroanatomy

Author

Manji, Hadi, primary, Connolly, Sean, additional, Dorward, Neil, additional, Kitchen, Neil, additional, Mehta, Amrish, additional, and Wills, Adrian, additional

Published
2007
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33. Chapter 5 Neurosurgery

Author

Manji, Hadi, primary, Connolly, Sean, additional, Dorward, Neil, additional, Kitchen, Neil, additional, Mehta, Amrish, additional, and Wills, Adrian, additional

Published
2007
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37. Pituitary macroadenomas: are combination antiplatelet and anticoagulant therapy contraindicated? A case report

Author

Tan Tricia MM, Caputo Carmela, Mehta Amrish, Hatfield Emma CI, Martin Niamh M, and Meeran Karim

Subjects
Medicine
Abstract

Abstract Background Pituitary apoplexy is a life-threatening endocrine emergency that is caused by haemorrhage or infarction of the pituitary gland, commonly within a pituitary adenoma. Patients classically present with headache, ophthalmoplegia, visual field defects and altered mental state, but may present with a typical symptoms such as fever and altered conscious level. Case presentation A 57-year-old female with a known pituitary macroadenoma was treated for suspected acute coronary syndrome with aspirin, clopidogrel and full dose enoxaparin. She developed a severe and sudden headache, nausea and vomiting and visual deterioration. A CT scan showed haemorrhage into the pituitary macroadenoma. She underwent neurosurgical decompression. Post-operatively her visual fields and acuity returned to baseline. She was continued on hydrocortisone and thyroxine replacement on discharge. Conclusion This case illustrates the risks of anticoagulation in a patient with a known pituitary macroadenoma, and raises the issue of whether these tumours present a relative contraindication to the use of dual antiplatelet and anticoagulation in acute coronary syndrome.

Published
2007
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39. Modulations of human resting brain connectivity by kisspeptin enhance sexual and emotional functions

Author

Comninos, Alexander N., primary, Demetriou, Lysia, additional, Wall, Matthew B., additional, Shah, Amar J., additional, Clarke, Sophie A., additional, Narayanaswamy, Shakunthala, additional, Nesbitt, Alexander, additional, Izzi-Engbeaya, Chioma, additional, Prague, Julia K., additional, Abbara, Ali, additional, Ratnasabapathy, Risheka, additional, Yang, Lisa, additional, Salem, Victoria, additional, Nijher, Gurjinder M., additional, Jayasena, Channa N., additional, Tanner, Mark, additional, Bassett, Paul, additional, Mehta, Amrish, additional, McGonigle, John, additional, Rabiner, Eugenii A., additional, Bloom, Stephen R., additional, and Dhillo, Waljit S., additional

Published
2018
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40. Clinical and biochemical characteristics of patients presenting with pituitary apoplexy

Author

Abbara, Ali, primary, Clarke, Sophie, additional, Eng, Pei Chia, additional, Milburn, James, additional, Joshi, Devavrata, additional, Comninos, Alexander N, additional, Ramli, Rozana, additional, Mehta, Amrish, additional, Jones, Brynmor, additional, Wernig, Florian, additional, Nair, Ramesh, additional, Mendoza, Nigel, additional, Sam, Amir H, additional, Hatfield, Emma, additional, Meeran, Karim, additional, Dhillo, Waljit S, additional, and Martin, Niamh M, additional

Published
2018
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42. List of Contributors

Author

Adams, Ashok, Addley, Helen, Agosto, Omar, Al Sarraf, Abdullah A., Alobeidi, Farah, Ameli-Renani, Seyed, Argyropoulou, Maria I., Arthurs, Owen, Balériaux, Danielle, Barber, Joy L., Barentsz, Jelle O., Barkhof, Frederik, Barnett, Joseph L., Barras, Christen D., Barrett, Tristan, Beale, Timothy, Beddy, Peter, Beigelman-Aubry, Catherine, Belli, Anna-Maria, Bhalla, Sanjeev, Bhattacharya, Joti Jonathan, Bogaert, Jan, Bomers, Joyce G.R., Boone, Darren, Bordonaro, Veronica, Breen, David J., Brillet, Pierre-Yves, Campbell, Robert S.D., Campion, Tom, Carey, Brian, Caroline, Dina F., Cazzato, Roberto Luigi, Chateil, Jean-François, Choudhury, Ananya, Chun, Joo-Young, Cook, Gary J.R., Copley, Susan J., Dass, Chandra, Davagnanam, Indran, Davies, A. Mark, Davies, Alun, de Rooij, Maarten, de Roos, Albert, Desai, Sujal R., Devaraj, Anand, Doran, Simon P., Easty, Marina, Evans, Andrew J., Fattori, Rossella, Fetita, Catalin I., Franquet, Tomás, Freeman, Alan H., Freeman, Susan, Gallagher, Ferdia A., Gangi, Afshin, Gibson, Robert N., Gillard, Jonathan H., Gleeson, Fergus, Godfrey, Edmund M., Goh, Vicky, Anson, Beatriz Gomez, Grainger, Andrew J., Granata, Claudio, Grenier, Philippe A., Gunny, Roxana S., Hadi, Mohammed, Hakim, Wasim, Hall, Charles B.O., Hamady, Mohamad, Hartmann, Ieneke J.C., Heaney, Roisin M., Hoskin, Peter, Hughes, Philip M., Humphries, Paul D., Jäger, H. Rolf, James, Steven L.J., James, Jonathan J., Javidan-Nejad, Cylen, Jawad, Susan, Johnson, Karl, Jones, Hefin, Jones, Brynmor P., Kapoor, Geeta, Kasthuri, Ram S., Katsanos, Konstantinos, Kavanagh, Richard G., Keeling, Aoife N., Kelly-Morland, Christian, Kenny, Lizbeth M., Kilburn-Toppin, Fleur, Kolokythas, Orpheus, Kopf, Helmut, Kremer, Stéphane, Krestan, Christian R., Kroft, Lucia J.M., Lagha, Eamon, Lalam, Radhesh, Lee, Michael J., Lomas, David J., Lovato, Luigi, MacVicar, David, Maher, Michael M., Mannelli, Lorenzo, Martin, Rachel M., Matys, Tomasz, McLaughlin, Patrick D., McNally, Eugene, Meaney, James F.M., Mehta, Amrish, Meirelles, Gustavo, Micallef, Caroline, Mistry, Alpesh, Miszkiel, Katherine, Morgan, Robert A., Mortensen, Kristian H., Moss, Jonathan G., Murray, Timothy E., Nair, Arjun, Nandra, Gurinder S., Natale, Luigi, O'Connor, Owen J., O'Connor, Philip, O'Donnell, Paul, Offiah, Amaka C., Olsen, Øystein E., Müller, Lil-Sofie Ording, O'Regan, Kevin, Owens, Catherine M., Padley, Simon P.G., Parizel, Paul M., Parkar, Nadeem, Patel, Anish, Patel, Uday, Patsch, Janina M., Pizzini, Francesca Benedetta, Plumb, Andrew, Popat, Sanjay, Power, Stephen P., Prezzi, Davide, Quail, Michael A., Rankine, James J., Ratnam, Lakshmi, Rawal, Bhavin, Reekers, Jim A., Reynolds, John H., Reznek, Rodney H., Riccabona, Michael, Rosendahl, Karen, Rottenberg, Giles, Rovira, Àlex, Rowbotham, Emma L., Russo, Vincenzo, Rutherford, Elizabeth E., Sabharwal, Tarun, Sahdev, Anju, Saifuddin, Asif, Sala, Evis, Saunders, Dawn E., Schima, Wolfgang, Scoffings, Daniel J., Screaton, Nicholas J., Sellon, Edward, Semple, Thomas R., Serrao, Eva M., Shaida, Nadeem, Shakur, Amreen, Sheikh-Bahaei, Nasim, Shepherd, Beth, Siebelink, Hans-Marc J., Silva, Mario, Singh, Jaspreet, Smith, Jan, Sundgren, Pia C., Sutherland, Tom R., Sverzellati, Nicola, Symons, Rolf, Taylor, Andrew M., Taylor, Stuart A., Thakor, Avnesh S., Thurnher, Majda M., Thust, Steffie, Toms, Andoni P., Tsakok, Maria, Tyler, Philippa, Uberoi, Raman, van den Hauwe, Luc, van Goethem, Johan W., Thielen, Thomas Van, Varghese, Sibu, Verma, Hema, Verschakelen, Johny A., Villeirs, Geert M., Vinnicombe, Sarah J., Warbey, Victoria S., Watson, Tom A., Westenberg, Jos J.M., Yadavali, Reddi Prasad, and Yamamoto, Adam Kenji

Published
2021
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43. Kisspeptin modulates resting brain activity to alter responses to negative stimuli in humans

Author

Comninos, Alexander, primary, Demetriou, Lysia, additional, Wall, Matt, additional, Shah, Amar, additional, Clarke, Sophie, additional, Narayanaswamy, Shakunthala, additional, Nesbitt, Alexander, additional, Izzi-Engbeaya, Chioma, additional, Prague, Julia, additional, Abbara, Ali, additional, Ratnasabapathy, Risheka, additional, Yang, Lisa, additional, Salem, Victoria, additional, Nijher, Monica, additional, Jayasena, Channa, additional, Tanner, Mark, additional, Bassett, Paul, additional, Mehta, Amrish, additional, Rabiner, Ilan, additional, Bloom, Stephen, additional, and Dhillo, Waljit, additional

Published
2017
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44. A challenging case of dual endocrine pathology

Author

Ramli, Rozana, primary, Steer, Keith, additional, Hatfield, Emma, additional, Mehta, Amrish, additional, Jones, Brynn, additional, Mendoza, Nigel, additional, Meeran, Karim, additional, and Martin, Niamh, additional

Published
2017
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46. Overlapping Networks Engaged during Spoken Language Production and Its Cognitive Control

Author

Geranmayeh, Fatemeh, Wise, Richard J.S., Mehta, Amrish, and Leech, Robert

Subjects
Adult, Male, Brain Mapping, Functional Neuroimaging, Brain, Articles, Middle Aged, Magnetic Resonance Imaging, Cognition, Speech Perception, Humans, Speech, Female, Nerve Net, Aged, Language
Abstract

Spoken language production is a complex brain function that relies on large-scale networks. These include domain-specific networks that mediate language-specific processes, as well as domain-general networks mediating top-down and bottom-up attentional control. Language control is thought to involve a left-lateralized fronto-temporal-parietal (FTP) system. However, these regions do not always activate for language tasks and similar regions have been implicated in nonlinguistic cognitive processes. These inconsistent findings suggest that either the left FTP is involved in multidomain cognitive control or that there are multiple spatially overlapping FTP systems. We present evidence from an fMRI study using multivariate analysis to identify spatiotemporal networks involved in spoken language production in humans. We compared spoken language production (Speech) with multiple baselines, counting (Count), nonverbal decision (Decision), and "rest," to pull apart the multiple partially overlapping networks that are involved in speech production. A left-lateralized FTP network was activated during Speech and deactivated during Count and nonverbal Decision trials, implicating it in cognitive control specific to sentential spoken language production. A mirror right-lateralized FTP network was activated in the Count and Decision trials, but not Speech. Importantly, a second overlapping left FTP network showed relative deactivation in Speech. These three networks, with distinct time courses, overlapped in the left parietal lobe. Contrary to the standard model of the left FTP as being dominant for speech, we revealed a more complex pattern within the left FTP, including at least two left FTP networks with competing functional roles, only one of which was activated in speech production.

Published
2014

48. Kisspeptin: A Novel Neuroendocrine Modulator of Sexual and Emotional Processing in Men

Author

Comninos, Alexander, primary, Wall, Matthew, additional, Demetriou, Lysia, additional, Shah, Amar, additional, Clarke, Sophie, additional, Narayanaswamy, Shakunthala, additional, Nesbitt, Alexander, additional, Izzi-Engbeaya, Chioma, additional, Prague, Julia, additional, Abbara, Ali, additional, Ratnasabapathy, Risheka, additional, Salem, Victoria, additional, Nijher, Gurjinder, additional, Jayasena, Channa, additional, Tanner, Mark, additional, Bassett, Paul, additional, Mehta, Amrish, additional, Rabiner, Eugenii, additional, Honigsperger, Christoph, additional, and Dhillo, Waljit, additional

Published
2016
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49. Managing a complex case of acromegaly - lessons to learn

Author

Lye, Yap Hsiu, primary, Hatfield, Emma, additional, Martin, Niamh, additional, Assomull, Ravi, additional, Berry, Stewart, additional, Mehta, Amrish, additional, Falconer, Alison, additional, Mendoza, Nigel, additional, Meeran, Karim, additional, and Mehta, Sanjeev, additional

Published
2016
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50. CTBRAIN MACHINE LEARNING PREDICTS STROKE THROMBOLYSIS RESULT

Author

Epton, Sarah, primary, Bentley, Paul, additional, Ganesalingam, Jeban, additional, Dias, Anomas, additional, Mahady, Kate, additional, Rinne, Paul, additional, Sharma, Pankaj, additional, Halse, Omid, additional, Mehta, Amrish, additional, and Rueckert, Daniel, additional

Published
2014
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