Search

Your search keyword '"Mehrotra, Sanjana"' showing total 194 results
Start Over Author "Mehrotra, Sanjana"
194 results on '"Mehrotra, Sanjana"'

6. A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC

Author

Darragh, Laurel B., Knitz, Michael M., Hu, Junxiao, Clambey, Eric T., Backus, Jennifer, Dumit, Andrew, Samedi, Von, Bubak, Andrew, Greene, Casey, Waxweiler, Timothy, Mehrotra, Sanjana, Bhatia, Shilpa, Gadwa, Jacob, Bickett, Thomas, Piper, Miles, Fakhoury, Kareem, Liu, Arthur, Petit, Joshua, Bowles, Daniel, Thaker, Ashesh, Atiyeh, Kimberly, Goddard, Julie, Hoyer, Robert, Van Bokhoven, Adrie, Jordan, Kimberly, Jimeno, Antonio, D’Alessandro, Angelo, Raben, David, McDermott, Jessica D., and Karam, Sana D.

Published
2022
Full Text
View/download PDF

11. Author Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC

Author

Darragh, Laurel B., Knitz, Michael M., Hu, Junxiao, Clambey, Eric T., Backus, Jennifer, Dumit, Andrew, Samedi, Von, Bubak, Andrew, Greene, Casey, Waxweiler, Timothy, Mehrotra, Sanjana, Bhatia, Shilpa, Gadwa, Jacob, Bickett, Thomas, Piper, Miles, Fakhoury, Kareem, Liu, Arthur, Petit, Joshua, Bowles, Daniel, Thaker, Ashesh, Atiyeh, Kimberly, Goddard, Julie, Hoyer, Robert, Van Bokhoven, Adrie, Jordan, Kimberly, Jimeno, Antonio, D’Alessandro, Angelo, Raben, David, McDermott, Jessica D., and Karam, Sana D.

Published
2023
Full Text
View/download PDF

16. RAD51 135G>C polymorphism in esophageal cancer and meta-analysis in gastrointestinal tract cancers

Author

Bali, Jagmohan, Sambyal, Vasudha, Guleria, Kamlesh, Mehrotra, Sanjana, Singh, Neeti, Uppal, Manjit, Manjari, Mridu, and Sudan, Meena

Subjects
Oncology, Experimental, Gastrointestinal cancer -- Genetic aspects -- Risk factors -- Development and progression, Single nucleotide polymorphisms -- Research, Cancer -- Research, Esophageal cancer -- Genetic aspects -- Risk factors -- Development and progression, Health
Abstract

Byline: Jagmohan. Bali, Vasudha. Sambyal, Kamlesh. Guleria, Sanjana. Mehrotra, Neeti. Singh, Manjit. Uppal, Mridu. Manjari, Meena. Sudan Background: A functional single-nucleotide polymorphism (SNP), 135G>C in the 5'UTR of the RAD51 [...]

Published
2022

17. Suboptimal Agreement Among Cytopathologists in Diagnosis of Malignancy Based on Endoscopic Ultrasound Needle Aspirates of Solid Pancreatic Lesions: A Validation Study

Author

Marshall, Carrie, Mounzer, Rawad, Hall, Matt, Simon, Violette, Centeno, Barbara, Dennis, Katie, Dhillon, Jasreman, Fan, Fang, Khazai, Laila, Klapman, Jason, Komanduri, Srinadh, Lin, Xiaoqi, Lu, David, Mehrotra, Sanjana, Muthusamy, V. Raman, Nayar, Ritu, Paintal, Ajit, Rao, Jianyu, Sams, Sharon, Shah, Janak, Watson, Rabindra, Rastogi, Amit, and Wani, Sachin

Published
2018
Full Text
View/download PDF

18. Author Correction: A phase I/Ib trial and biological correlate analysis of neoadjuvant SBRT with single-dose durvalumab in HPV-unrelated locally advanced HNSCC

Author

Darragh, Laurel B., primary, Knitz, Michael M., additional, Hu, Junxiao, additional, Clambey, Eric T., additional, Backus, Jennifer, additional, Dumit, Andrew, additional, Samedi, Von, additional, Bubak, Andrew, additional, Greene, Casey, additional, Waxweiler, Timothy, additional, Mehrotra, Sanjana, additional, Bhatia, Shilpa, additional, Gadwa, Jacob, additional, Bickett, Thomas, additional, Piper, Miles, additional, Fakhoury, Kareem, additional, Liu, Arthur, additional, Petit, Joshua, additional, Bowles, Daniel, additional, Thaker, Ashesh, additional, Atiyeh, Kimberly, additional, Goddard, Julie, additional, Hoyer, Robert, additional, Van Bokhoven, Adrie, additional, Jordan, Kimberly, additional, Jimeno, Antonio, additional, D’Alessandro, Angelo, additional, Raben, David, additional, McDermott, Jessica D., additional, and Karam, Sana D., additional

Published
2022
Full Text
View/download PDF

23. Common variants in the HLA-DRB1–HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis

Author

Fakiola, Michaela, Strange, Amy, Cordell, Heather J, Miller, E Nancy, Pirinen, Matti, Su, Zhan, Mishra, Anshuman, Mehrotra, Sanjana, Monteiro, Gloria R, Band, Gavin, Bellenguez, Céline, Dronov, Serge, Edkins, Sarah, Freeman, Colin, Giannoulatou, Eleni, Gray, Emma, Hunt, Sarah E, Lacerda, Henio G, Langford, Cordelia, Pearson, Richard, Pontes, Núbia N, Rai, Madhukar, Singh, Shri P, Smith, Linda, Sousa, Olivia, Vukcevic, Damjan, Bramon, Elvira, Brown, Matthew A, Casas, Juan P, Corvin, Aiden, Duncanson, Audrey, Jankowski, Janusz, Markus, Hugh S, Mathew, Christopher G, Palmer, Colin N A, Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J, Trembath, Richard C, Viswanathan, Ananth C, Wood, Nicholas W, Wilson, Mary E, Deloukas, Panos, Peltonen, Leena, Christiansen, Frank, Witt, Campbell, Jeronimo, Selma M B, Sundar, Shyam, Spencer, Chris C A, Blackwell, Jenefer M, and Donnelly, Peter

Published
2013
Full Text
View/download PDF

35. Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India

Author

Mehrotra Sanjana, Fakiola Michaela, Oommen Joyce, Jamieson Sarra E, Mishra Anshuman, Sudarshan Medhavi, Tiwary Puja, Rani Deepa, Thangaraj Kumarasamy, Rai Madhukar, Sundar Shyam, and Blackwell Jenefer M

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background IL8RA and IL8RB, encoded by CXCR1 and CXCR2, are receptors for interleukin (IL)-8 and other CXC chemokines involved in chemotaxis and activation of polymorphonuclear neutrophils (PMN). Variants at CXCR1 and CXCR2 have been associated with susceptibility to cutaneous and mucocutaneous leishmaniasis in Brazil. Here we investigate the role of CXCR1/CXCR2 in visceral leishmaniasis (VL) in India. Methods Three single nucleotide polymorphisms (SNPs) (rs4674259, rs2234671, rs3138060) that tag linkage disequilibrium blocks across CXCR1/CXCR2 were genotyped in primary family-based (313 cases; 176 nuclear families; 836 individuals) and replication (941 cases; 992 controls) samples. Family- and population-based analyses were performed to look for association between CXCR1/CXCR2 variants and VL. Quantitative RT/PCR was used to compare CXCR1/CXCR2 expression in mRNA from paired splenic aspirates taken before and after treatment from 19 VL patients. Results Family-based analysis using FBAT showed association between VL and SNPs CXCR1_rs2234671 (Z-score = 2.935, P = 0.003) and CXCR1_rs3138060 (Z-score = 2.22, P = 0.026), but not with CXCR2_rs4674259. Logistic regression analysis of the case-control data under an additive model of inheritance showed association between VL and SNPs CXCR2_rs4674259 (OR = 1.15, 95%CI = 1.01-1.31, P = 0.027) and CXCR1_rs3138060 (OR = 1.25, 95%CI = 1.02-1.53, P = 0.028), but not with CXCR1_rs2234671. The 3-locus haplotype T_G_C across these SNPs was shown to be the risk haplotype in both family- (TRANSMIT; P = 0.014) and population- (OR = 1.16, P = 0.028) samples (combined P = 0.002). CXCR2, but not CXCR1, expression was down regulated in pre-treatment compared to post-treatment splenic aspirates (P = 0.021). Conclusions This well-powered primary and replication genetic study, together with functional analysis of gene expression, implicate CXCR2 in determining outcome of VL in India.

Published
2011
Full Text
View/download PDF

36. No evidence for association between SLC11A1 and visceral leishmaniasis in India

Author

Fakiola Michaela, Jamieson Sarra E, Tiwary Puja, Sudharshan Medhavi, Mishra Anshuman, Oommen Joyce, Mehrotra Sanjana, Rani Deepa, Thangaraj Kumarasamy, Rai Madhukar, Sundar Shyam, and Blackwell Jenefer M

Subjects
SLC11A1, visceral leishmaniasis, genetic susceptibility, Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background SLC11A1 has pleiotropic effects on macrophage function and remains a strong candidate for infectious disease susceptibility. 5' and/or 3' polymorphisms have been associated with tuberculosis, leprosy, and visceral leishmaniasis (VL). Most studies undertaken to date were under-powered, and none has been replicated within a population. Association with tuberculosis has replicated variably across populations. Here we investigate SLC11A1 and VL in India. Methods Nine polymorphisms (rs34448891, rs7573065, rs2276631, rs3731865, rs17221959, rs2279015, rs17235409, rs17235416, rs17229009) that tag linkage disequilibrium blocks across SLC11A1 were genotyped in primary family-based (313 cases; 176 families) and replication (941 cases; 992 controls) samples. Family- and population-based analyses were performed to look for association between SLC11A1 variants and VL. Quantitative RT/PCR was used to compare SLC11A1 expression in mRNA from paired splenic aspirates taken before and after treatment from 24 VL patients carrying different genotypes at the functional promoter GTn polymorphism (rs34448891). Results No associations were observed between VL and polymorphisms at SLC11A1 that were either robust to correction for multiple testing or replicated across primary and replication samples. No differences in expression of SLC11A1 were observed when comparing pre- and post-treatment samples, or between individuals carrying different genotypes at the GTn repeat. Conclusions This is the first well-powered study of SLC11A1 as a candidate for VL, which we conclude does not have a major role in regulating VL susceptibility in India.

Published
2011
Full Text
View/download PDF

37. Neutrophils and Visceral Leishmaniasis: Impact on innate immune response and cross‐talks with macrophages and dendritic cells.

Author

Kupani, Manu, Pandey, Rajeev K., and Mehrotra, Sanjana

Subjects
VISCERAL leishmaniasis, DENDRITIC cells, IMMUNE response, MACROPHAGES, CUTANEOUS leishmaniasis, NEUTROPHILS
Abstract

Neutrophils with their array of microbicidal activities are the first innate immune cells to guard against infection. They are also most crucial for the host's initial defense against Leishmania parasites which cause clinically diverse diseases ranging from self‐healing cutaneous leishmaniasis (CL) to a more severe visceral form, visceral leishmaniasis (VL). Neutrophils are recruited in large numbers at the infection site after bite of sandfly, which is the vector for the disease. The initial interaction of neutrophils with the parasites may modulate the subsequent innate and adaptive immune responses and hence affect the disease outcome. The purpose of this review is to comprehensively appraise the role of neutrophils during the early stages of Leishmania infection with a focus on the visceral form of the disease. In the past decade, new insights regarding the role of neutrophils in VL have surfaced which have been extensively elaborated in the present review. In addition, since much of the information regarding neutrophil–Leishmania early interaction has accumulated through studies on mouse models of CL, these studies are also revisited. We begin by reviewing the factors which drive the recruitment of neutrophils at the site of injection by the sandfly. We then discuss the studies delineating the molecular mechanisms involved in the uptake of the Leishmania parasite by neutrophils and how the parasite subverts their microbicidal functions. In the end, the interaction of infected neutrophils with macrophages and dendritic cells is summarized. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

41. 113 Predictors of Interobserver Variability (Iov) Among Cytopathologists (Cyps) Evaluating Pancreatic Endoscopic Ultrasound-Guided Fine Needle Aspiration (EUS-FNA) Cytology Specimens: A Multicenter Validation Study

Author

Mounzer, Rawad, primary, Marshall, Carrie B., additional, Hall, Matt, additional, Simon, Violette C., additional, Centeno, Barbara A., additional, Dennis, Katie, additional, Dhillon, Jasreman, additional, Fan, Fang, additional, Khazai, Laila, additional, Klapman, Jason B., additional, Komanduri, Sri, additional, Lin, Xiaoqi, additional, Lu, David, additional, Mehrotra, Sanjana, additional, Muthusamy, V. Raman, additional, Nayar, Ritu, additional, Paintal, Ajit, additional, Rao, Jianyu, additional, Sams, Sharon, additional, Shah, Janak N., additional, Tynan, Timothy M., additional, Watson, Rabindra R., additional, Rastogi, Amit, additional, and Wani, Sachin B., additional

Published
2017
Full Text
View/download PDF

43. Suboptimal Interobserver Agreement (IOA) Amongt Cytopathologists (CYPS) for Pancreatic Endoscopic Ultrasound Fine Needle Aspiration (EUS-FNA) Cytology Specimens: a Multicenter Validation Study

Author

Wani, Sachin B., primary, Mounzer, Rawad, additional, Hall, Matt, additional, Simon, Violette C., additional, Centeno, Barbara A., additional, Dennis, Katie, additional, Dhillon, Jasreman, additional, Fan, Fang, additional, Khazai, Laila, additional, Klapman, Jason B., additional, Komanduri, Sri, additional, Lin, Xiaoqi, additional, Lu, David, additional, Mehrotra, Sanjana, additional, Raman Muthusamy, V., additional, Nayar, Ritu, additional, Paintal, Ajit, additional, Rao, Jianyu, additional, Sams, Sharon, additional, Shah, Janak N., additional, Tynan, Timothy M., additional, Watson, Rabindra R., additional, Rastogi, Amit, additional, and Marshall, Carrie B., additional

Published
2017
Full Text
View/download PDF

46. Interobserver agreement among cytopathologists in the evaluation of pancreatic endoscopic ultrasound-guided fine needle aspiration cytology specimens

Author

Mounzer, Rawad, additional, Yen, Roy, additional, Marshall, Carrie, additional, Sams, Sharon, additional, Mehrotra, Sanjana, additional, Said, Mohamed, additional, Obuch, Joshua, additional, Brauer, Brian, additional, Attwell, Augustin, additional, Fukami, Norio, additional, Shah, Raj, additional, Amateau, Stuart, additional, Hall, Matthew, additional, Hosford, Lindsay, additional, Wilson, Robert, additional, Rastogi, Amit, additional, and Wani, Sachin, additional

Published
2016
Full Text
View/download PDF

47. Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis

Author

LeishGEN Consortium, Wellcome Trust Case Control Consortium 2, Fakiola, Michaela, Strange, Amy, Cordell, Heather J, Miller, E Nancy, Pirinen, Matti, Su, Zhan, Mishra, Anshuman, Mehrotra, Sanjana, Monteiro, Gloria R, Band, Gavin, Bellenguez, Céline, Dronov, Serge, Edkins, Sarah, Freeman, Colin, Giannoulatou, Eleni, Gray, Emma, Hunt, Sarah E, Lacerda, Henio G, Langford, Cordelia, Pearson, Richard, Pontes, Núbia N, Rai, Madhukar, Singh, Shri P, Smith, Linda, Sousa, Olivia, Vukcevic, Damjan, Bramon, Elvira, Brown, Matthew A, Casas, Juan P, Corvin, Aiden, Duncanson, Audrey, Jankowski, Janusz, Markus, Hugh S, Mathew, Christopher G, Palmer, Colin NA, Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J, Trembath, Richard C, Viswanathan, Ananth C, Wood, Nicholas W, Wilson, Mary E, Deloukas, Panos, Peltonen, Leena, Christiansen, Frank, Witt, Campbell, Jeronimo, Selma MB, Sundar, Shyam, Spencer, Chris CA, Blackwell, Jenefer M, and Donnelly, Peter

Abstract

To identify susceptibility loci for visceral leishmaniasis, we undertook genome-wide association studies in two populations: 989 cases and 1,089 controls from India and 357 cases in 308 Brazilian families (1,970 individuals). The HLA-DRB1-HLA-DQA1 locus was the only region to show strong evidence of association in both populations. Replication at this region was undertaken in a second Indian population comprising 941 cases and 990 controls, and combined analysis across the three cohorts for rs9271858 at this locus showed P(combined) = 2.76 × 10(-17) and odds ratio (OR) = 1.41, 95% confidence interval (CI) = 1.30-1.52. A conditional analysis provided evidence for multiple associations within the HLA-DRB1-HLA-DQA1 region, and a model in which risk differed between three groups of haplotypes better explained the signal and was significant in the Indian discovery and replication cohorts. In conclusion, the HLA-DRB1-HLA-DQA1 HLA class II region contributes to visceral leishmaniasis susceptibility in India and Brazil, suggesting shared genetic risk factors for visceral leishmaniasis that cross the epidemiological divides of geography and parasite species.

Published
2013

48. Tu1620 Variable Interobserver Agreement (IOA) Among Cytopathologists (CyPs) in the Evaluation of Pancreatic Endoscopic Ultrasound-Guided Fine Needle Aspiration (EUS-FNA) Cytology Specimens

Author

Mounzer, Rawad, primary, Yen, Roy D., additional, Marshall, Carrie, additional, Sams, Sharon B., additional, Mehrotra, Sanjana, additional, Said, Sherif, additional, Hall, Matthew, additional, Hosford, Lindsay, additional, Rastogi, Amit, additional, and Wani, Sachin, additional

Published
2015
Full Text
View/download PDF

49. Tu1938 Predictors of Interobserver Variability (IOV) Among Cytopatologists (CyPs) in the Diagnosis of Pancreatic Endoscopic Ultrasound-Guided Fine Needle Aspiration (EUS-FNA) Cytology Specimens

Author

Mounzer, Rawad, primary, Yen, Roy D., additional, Marshall, Carrie, additional, Sams, Sharon B., additional, Mehrotra, Sanjana, additional, Said, Sherif, additional, Hall, Matthew, additional, Hosford, Lindsay, additional, Rastogi, Amit, additional, and Wani, Sachin, additional

Published
2015
Full Text
View/download PDF

50. Su1257 - Suboptimal Interobserver Agreement (IOA) Amongt Cytopathologists (CYPS) for Pancreatic Endoscopic Ultrasound Fine Needle Aspiration (EUS-FNA) Cytology Specimens: a Multicenter Validation Study

Author

Wani, Sachin B., Mounzer, Rawad, Hall, Matt, Simon, Violette C., Centeno, Barbara A., Dennis, Katie, Dhillon, Jasreman, Fan, Fang, Khazai, Laila, Klapman, Jason B., Komanduri, Sri, Lin, Xiaoqi, Lu, David, Mehrotra, Sanjana, Raman Muthusamy, V., Nayar, Ritu, Paintal, Ajit, Rao, Jianyu, Sams, Sharon, Shah, Janak N., Tynan, Timothy M., Watson, Rabindra R., Rastogi, Amit, and Marshall, Carrie B.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results