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Tailored reaction of Schiff base ligands with palladium(II) chloride and imidazole afford three complexes of formula [Pd(II)(L)(imdz)2]Cl, which are L = 2-((E)-(p-lylimino)methyl)-6-methoxyphenol (complex 1), 2-methoxy- -6-((E)-(phenylimine)methyl)phenol (complex 2) and 2-((E)-(4-chlorophenylimino) methyl)-6-methoxyphenol (complex 3). Compounds were characterized with elemental analysis, molar conductance, electronic spectroscopy, ESI-MS, FT-IR, TGA, 1H-NMR and 13C-NMR. Molecular structure and different quantum chemical parameters were calculated using the B3LYP basis set of density functional theory with the standard 6-311+G (d, 2p) level. The catalytic potential of 1-3 was examined over Heck-Mizoroki reaction and found in order of 1 > 2 > 3.

In this study, a dinucleating spacer incorporating two 2-aminopyridine units has been used to prepare seven novel dinuclear compounds. These molecules were characterized by elemental analyses, conductivity measurements, magnetic susceptibility, FT-IR, FAB-Mass, electronic, 1H and 13C{1H}NMR spectral studies. The complex [{trans,mer-RuCl2(DMSO)3}2(μ-5,5'-methylenebis(2-aminopyridine))].2DMSO, 2 was also characterized through 1H-1H COSY NMR. There are mainly three different formulations; [{cis,fac-RuCl2(SO)3}2(μ-MBAP)].2SO; [{trans,mer-RuCl2(SO)3}2(μ-MBAP)].2SO and [{trans-RuCl4(SO)}2(μ-MBAP)]2- [X]2+; where SO = DMSO / TMSO; MBAP = 5,5'-methylenebis(2-aminopyridine) and [X]+ = [(DMSO)2H]+, Na+ or [(TMSO)H]+. The coordination was found through cyclic nitrogen of pyridine ring in octahedral environment for both metal centers. The chemical behivour of [{cis,fac-RuCl2(DMSO)3}2(μ-5,5'-methylenebis(2-aminopyridine))].2DMSO, 1 and 2 in aqueous solution with respect to time was observed by conductivity measurements and UV-vis spectrophotometer. All complexes were found to possess prominent antibacterial activity against Escherichia coli in comparison to Chloramphenicol and Gatifloxacin.

Drug resistance in pathogens is a growing global health problem. The development of new drugs is a risky, time-consuming, and expensive process, since only a few got final approval. Organometallic compounds attracted attention due to their promising anticancer activities. In this study, four cyclometallates containing ruthenium and rhodium ions were synthesized from two phenolic azo ligands. These molecules were characterized by elemental analyses, molar conductance measurements, magnetic susceptibility, FT-IR, mass, electronic,1H,13C{1H}, and31P{1H} NMR spectral studies. The general formula for the complexes istrans-[M(PPh3)2(Cl)(L)], where M = Rh or Ru, PPh3 = triphenylphosphine, and L = phenolic azo ligand. All the complexes possess prominent antibacterial activity againstEscherichia coliandMycobacterium tuberculosisas compared to market drugs. The interactions of rhodium derivatives with plasma–protein were also studied. Cyclometalation of a pendant aromatic ring is an example of C–H bond activation. Organometallic compounds were biologically potent and may be helpful for pharmaceutical industries for biological targets. [ABSTRACT FROM PUBLISHER]

Six complexes of Zn(II), Cd(II) and Hg(II) with sulphur containing Schiff base ligand, 1,4-bis((1 H-pyrrol-2-yl)methylene)thiosemicarbazide in 1:1 and 1:2 ratio has been synthesized. Complexes were characterized by molar conductance measurement, elemental analyses, FT-IR, 1H-NMR, and FAB/ESI-Mass. The complexes were used as a single source precursor for the synthesis of ZnS/CdS/HgS nanoparticles by their thermal decomposition in the presence of different surfactants. The precursor: surfactant ratio and temperature plays important role in determining the size of the nanoparticles. The size and morphology of nanoparticles has been ascertained by UV-Vis spectroscopy, XRD measurements and Transmission Electron Microscopy (TEM). Schiff base, complexes and nanoparticles were tested for antibacterial activity and MIC values against E. coli. The complexes were found more potent than the corresponding Schiff bases and nanoparticles. [ABSTRACT FROM AUTHOR]