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Byline: Sumit. Mehndiratta Phenytoin is a commonly used antiepileptic medication in the pediatric age group, but it has a narrow therapeutic range. Various adverse effects have been reported commonly. We [...]

The prevalence of hepatitis C virus (HCV) infection in Pediatric patients with lymphoproliferative diseases has most commonly been reported with B cell Non-Hodgkin lymphoma. Case studies have reported the requirement of dose reduction or suspension of chemotherapy in 80% of Pediatric ALL cases who are anti-HCV positive owing to hepatotoxicity. The standard of care anti HCV therapy in children aged 3-17 years had been peginterferon and ribavirin for 48 weeks. FDA approved pan-genotypic, anti- HCV regimen, sofosbuvir/velpatasvir [SOF/VEL], for the Pediatric population >6yrs of age or >17 kg body weight in March 2020. We herein report a case of an HCV infected Pediatric B cell ALL patient who was treated with SOF/VEL concomitantly with an intensive chemotherapy regimen. Child tolerated the full dose chemotherapy along with antivirals for 12 weeks and was in morphological remission with sustained virological response. [ABSTRACT FROM AUTHOR]

Byline: T. Abiramalatha, Sumit. Mehndiratta, Krishnan. Rajeshwari, Anand. Dubey Sir, Piperazine citrate is used as a vermifuge in pediatric practice. Various neurotoxic side effects of piperazine have been reported in [...]

Byline: Hema. Mittal, Sumit. Mehndiratta, Jaya. Kaushik, Tushar. Godbole Sir, De Sanctis-Cacchione syndrome (DSC) (MIM #278800) is a rare autosomal recessive disorder with a gene map locus of 10q11, originally [...]

Byline: Sumit. Mehndiratta, Krishnan. Rajeshwari, Anand. Dubey Sir, Guillain-Barré syndrome (GBS) is a rare complication of typhoid fever and only a few such cases have been reported in the pediatric [...]

Dengue fever has classically been described as a disease of children and young adults. Infants are naturally protected by virtue of maternally derived immunoglobulins, especially in endemic countries. The resurgence of dengue, coupled with the availability of early and sensitive diagnostic methods and a high degree of clinical suspicion, has led to an increasing number of infants being diagnosed. There is a wide spectrum of clinical manifestations, particularly in infancy. Here we describe three cases presenting with diverse clinical features, their subsequent management and outcome. [ABSTRACT FROM AUTHOR]

Alexander disease (AD) is an autosomal dominant leukodystrophy which predominantly affects infants and children. The infantile form comprises the most common form of AD. It presents before two years of age and characterized by macrocephaly, psychomotor regression, spasticity, pyramidal sign, ataxia and seizures. The diagnosis is based on magnetic resonance imaging (MRI) findings and confirmed by Glial fibrillary acidic protein (GFAP) gene molecular testing. We report an Indian case with normal head circumference. [ABSTRACT FROM AUTHOR]