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31 results on '"Meghpara, Beeran"'

1. Corneal Manifestations of Metabolic Disease

Author

Syed, Zeba A., Meghpara, Beeran B., Hammersmith, Kristin M., Rapuano, Christopher J., Azar, Dimitri T., Section editor, Rosenblatt, Mark I., Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
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12. Non-Descemet stripping endothelial keratoplasty in an adolescent with aphakia and glaucoma drainage device

Author

Chung, Seung, Meghpara, Beeran, Price, Jade, and Levin, Alex

Subjects
Aphakia -- Care and treatment -- Patient outcomes, Vision disorders in children -- Care and treatment -- Patient outcomes, Glaucoma -- Care and treatment -- Patient outcomes, Cornea -- Transplantation, Health
Abstract

Byline: Seung. Chung, Beeran. Meghpara, Jade. Price, Alex. Levin We describe the case of a 14-year-old patient with secondary endothelial failure that was treated with non-Descemet stripping endothelial keratoplasty (nDSEK). [...]

Published
2022

14. Contributors

Author

Afshari, Natalie A., Agarwal, Kanika, Ahmed, Tasnia, Al-Mohtaseb, Zaina, Ayres, Brandon D., Beazer, Alex P., Brooks, Cassandra C., Chamberlain, Winston, Chen, Lauren, Ciralsky, Jessica Blair, Dhaliwal, Deepinder Kaur, Djalilian, Ali R., Donaldson, Kendall E., Farid, Marjan, Gupta, Preeya K., Jhanji, Vishal, Knezevic, Alexander, Koch, Douglas D., Lin, Amy, Mah, Francis S., Majmudar, Parag A., Majmudar, Shivani, Meghpara, Beeran B., Mittal, Aman, Moussa, Kareem, Nakatsuka, Austin S., Pflugfelder, Stephen C., Pollard, Margaret C., Rapuano, Christopher J., Rhee, Michelle K., Rosenberg, Eric, Schallhorn, Julie Marie, Seo, Kyoung Yul, Shen, Elizabeth, Smith, Ryan G., Starnes, Taylor W., Stutzman, Richard, Sundararajan, Miel, Syed, Zeba A., Tu, Elmer Y., Vaidya, Neel, Wade, Matthew, Wang, Yvonne, Xie, Kate, and Yeu, Elizabeth

Published
2025
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23. List of Contributors

Author

Abbott, Richard L., Acharya, Nisha R., Aggarwal, Shruti, Aldave, Anthony J., Alfonso, Eduardo C., Al-Mohtaseb, Zaina, Alvarenga, Lênio Souza, Alward, Wallace L.M., Ambrósio, Renato, Jr., Ang, Andrea Y., Ang, Marcus, Anwar, Mohammad, Arepalli, Sruthi, Asbell, Penny A., Bahar, Irit, Baik, Annie K., Bakshi, Shaunak K., Belin, Michael W., Benetz, Beth A., Biber, Joseph M., Boese, Erin A., Bohm, Kelley, Bonnet, Clemence, Bouchard, Charles S., Brandt, James D., Brissette, Ashley R., Brooks, Cassandra C., Burkat, Cat N., Busin, Massimo, Cameron, J. Douglas, Campos, Mauro, Cao, Danmin, Carpel, Emmett F., Cavanagh, H. Dwight, Chai, Jean S.M., Chan, Clara C., Chang, Bernard H., Chen, Jenny, Chen, Michael C., Chern, Kenneth C., Cheung, Albert Y., Chodosh, James, Choi, Michael B., Choulakian, Mazen Y., Chung, Gary, Ciolino, Joseph B., Ciralsky, Jessica B., Colby, Kathryn A., Coroneo, Minas T., Cortina, Maria Soledad, Cortés, Dennis E., Crawford, Alexandra Z., Daluvoy, Melissa B., Dantas, Paulo Elias C., Darvish-Zargar, Mahshad, Davidson, Richard S., de Freitas, Denise, Cruz, Jose de la, DeMatteo, Jennifer, Djalilian, Ali R., Donnenfeld, Eric D., Drury, Donna C., Dunbar, Grace E., Dunn, Steven P., Eagle, Ralph C., Jr., Eghrari, Allen O., Eslami, Maryam, Eslani, Medi, Ewald, Mark D., Farahani, Mina A., Farbman, Neil, Farid, Marjan, Farooq, Asim V., Feder, Robert S., Felberg, Sergio, Feng, Matthew T., Fontana, Luigi, Foulks, Gary N., Fram, Nicole R., Galor, Anat, Garg, Prashant, Garg, Sumit, Glasser, David B., Goldman, Julie, Goldstein, Debra A., Golen, Jeffrey R., Gonzales, John A., Gottsch, John D., Graue-Hernández, Enrique O., Greenstein, Steven A., Gregory, Darren G., Greiner, Mark A., Gris, Oscar, Groos, Erich B., Jr., Gruzensky, William D., Güell, Jose L., Guerra, Frederico P., Gupta, Arushi, Gupta, Nidhi, Gupta, Preeya K., Hamill, M. Bowes, Hamilton, D. Rex, Hammersmith, Kristin M., Hannush, Sadeer B., Hardten, David R., Hellman, Justin, Henriquez, Maria, Hersh, Peter S., Hofling-Lima, Ana Luisa, Holland, Edward J., Holland, Gary N., Hong, Augustine R., Honig, Marc A., Hood, Christopher T., Hoskins, Eliza N., Hou, Joshua H., Huang, Andrew J.W., Huang, David, Hui, Jennifer I., Huynh, Kyle, Iovieno, Alfonso, Ip, Matthew H., Iuorno, Joseph D., Izquierdo, Luis, Jr., Jabbehdari, Sayena, Jacobs, Deborah S., Jakobiec, Frederick A., Jeng, Bennie H., Jester, James V., Jordan, David R., Kanjee, Raageen, Karp, Carol L., Kaufman, Stephen C., Keenan, Jeremy D., Kersten, Robert C., Khanna, Rohit C., Kim, Eric J., Kim, Stella K., Kim, Terry, Kinoshita, Shigeru, Kirkness, Colin M., Klyce, Stephen D., Koch, Douglas D., Kohnen, Thomas, Koizumi, Noriko, Kook, Daniel, Kowalski, Regis P., Kruse, Friedrich E., Kumar, Priyanka, Kurji, Khaliq, Lai, Edward, Lass, Jonathan H., Le, Hong-Gam, Lee, Samuel H., Lee, W. Barry, Lemp, Michael A., Li, Jennifer Y., Li, Yan, Lietman, Thomas M., Lim, Michele C., Lin, Lily Koo, Lin, Shawn R., Lindquist, T. Peter, Lindquist, Thomas D., Lindstrom, Richard L., Ling, Jennifer, Liu, Yu-Chi, Luz, Allan, Macsai, Marian S., Mah, Francis, Mannis, Gabriel N., Mannis, Mark J., Mannis, Tova, Martinez, Carlos E., Mártonyi, Csaba L., Sainz de la Maza, Maite, McGee, Hall T., McGhee, Charles N.J., Meghpara, Beeran, Mehta, Jodhbir S., Mian, Shahzad I., Miller, Darlene, Morishige, Naoyuki, Morkin, Melina I., Morral, Mercè, Moss, Adam, Naids, Steven, Nanji, Afshan A., Neff, Kristiana D., Nehls, Sarah M., Nelson, Patrick, Nerad, Jeffrey A., Nischal, Ken K., Nishida, Teruo, Nishiwaki-Dantas, Maria Cristina, Nofal, Nour, Ofori, Daniel, Ong, Hon Shing, Palay, David A., Paranjpe, Deval R., Parikh, Mansi, Park, Jennifer, Parsons, Matthew R., Pasadhika, Sirichai, Patel, Dipika V., Pearlstein, Eric S., Pepose, Jay S., Peralta, Robert J., Perez, Victor L., Perez Velasquez, Mauricio A., Petroll, W. Matthew, Pierson, Kasey, Price, Francis W., Jr., Price, Marianne O., Probst, Louis E., Qureshi, Sana, Ramos, Sam, Rao, Gullapalli N., Rapuano, Christopher J., Redenbo, Ellen F., Reidy, James J., Reilly, Charles, Reiser, Bibiana Jin, Riau, Andri K., Riveroll-Hannush, Lorena, Rizzuti, Allison E., Robertson, Danielle M., Rojas, Mario J., Rootman, David S., Rosenbaum, James T., Rosenberg, Eric D., Roth, Bryan M., Roy, Aravind, Sadowsky, Alan E., Saika, Shizuya, Salisbury, C. Drew, Salz, James, Sandhu, Simrenjeet, Sangwan, Virender S., Santaella, Gisella, Sarnicola, Caterina, Sarnicola, Enrica, Sarnicola, Vincenzo, Schmidt, Gregory A., Schockman, Samantha L., Schteingart, Miriam T., Schwab, Ivan R., Schwam, Brian L., Schwartz, Gary S., Scorcia, Vincenzo, See, Craig, Severinsky, Boris, Shah, Kevin J., Shajari, Mehdi, Shamie, Neda, Shen, Elizabeth, Shimmura, Shigeto, Shin, Afua, Sierra, Patricia, Silas, Megan R., Skolnick, Craig A., Slomovic, Allan R., Snyder, Michael E., Song, Jonathan C., Sorkin, Nir, Sotozono, Chie, Barbosa de Sousa, Luciene, Srinivasan, Sathish, Stagner, Anna M., Starr, Christopher E., Stein, Raymond, Steinert, Roger, Stoica, Basil T.L., Straiko, Michael D., Sugar, Alan, Sugar, Joel, Ta, Christopher N., Tabbara, Khalid F., Tan, Donald T.H., C.K. Tan, Jeremy, Tausif, Hassan N., Taylor, Shabnam, Terry, Mark A., Tognon, Taíse, Tong, C. Maya, Torres-Netto, Emilio A., Traboulsi, Elias I., Trattler, William, Trinh, Tanya, Tse, David T., Tsui, Edmund, Tu, Elmer Y., Vadboncoeur, Julie, Valenzuela, Felipe A., Vargason, Caroline W., Verdier, David D., Vieira, Ana Carolina, Viriya, Elizabeth T., Vislisel, Jesse M., Vukich, John A., Wade, Matthew, Warner, Michael A., Weikert, Mitchell P., Weinstein, Jessica E., Weiss, Jayne S., Wildes, Michael, Wilhelmus, Kirk R., Williamson, Samantha, Wilson, Steven E., Yeu, Elizabeth, Yu, Charles, Zaguia, Fatma, Zhang, Lucy Y., Zhao, Hui, and Zhu, Dagny

Published
2022
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27. Cyropreserved amniotic membrane option for management of DED, NK.

Author

Meghpara, Beeran

Subjects
*TREATMENT of keratitis, *DRY eye syndromes, *AMNION, *OPHTHALMIC drugs, *CRYOPRESERVATION of organs, tissues, etc., *KERATITIS, *CORNEA, *INNERVATION
Abstract

The author discusses the management option of cyropreserved amniotic membrane for dry eye disease (DED) and neurotrophic keratitis (NK) in 2023. Topics covered include the pathogenesis interconnection of DED and NK which can help in diagnosis, both complex diseases' requirement of a layered approach to management, and the use of cryopreserved amniotic membrane (CAM) to suppress inflammation and promote corneal reinnervation. Also noted is the author's firsthand experience with CAM.

Published
2023

30. Expression of α-crystallin in the retina of human sympathetic ophthalmia.

Author

Kase S, Meghpara BB, Ishida S, and Rao NA

Subjects
Apoptosis, Humans, Immunohistochemistry, In Situ Nick-End Labeling, Ophthalmia, Sympathetic pathology, Photoreceptor Cells metabolism, alpha-Crystallin A Chain metabolism, alpha-Crystallin B Chain metabolism, alpha-Crystallins genetics, Gene Expression Regulation, Ophthalmia, Sympathetic metabolism, Retina metabolism, alpha-Crystallins metabolism
Abstract

Sympathetic ophthalmia (SO) is a bilateral, granulomatous, intraocular inflammation that occurs following a penetrating injury to one eye, and has the potential to cause blindness of both eyes. The aim of this study was to examine the expression of α-crystallin and to detect apoptotic cells in the retina of human eyes with SO. Five globes, including three with SO and two age-matched normal appearing retinae, were examined. Formalin-fixed, paraffin-embedded tissue sections were submitted to hematoxylin and eosin staining and immuno-histochemistry with anti-αA and αB-crystallin antibodies. Apoptotic cells were detected using the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) method, and double-staining immunohistochemistry was conducted together with the TUNEL reaction. In normal-appearing retina, αA-crystallin immunoreactivity was predominantly detected in the cytoplasm of photoreceptors, where αB-crystallin was less marked. In SO globes, granulomatous inflammation was noted in the choroid, whereas the retina and choriocapillaris were preserved. Immunoreactivity for αA-crystallin was detected in the retina, as well as in the cytoplasm and inner/outer photoreceptor segments. By contrast, αB-crystallin was weakly noted in the SO retina. Double-staining immuno-histochemistry revealed no TUNEL-positive photoreceptors in the retina displaying high immunoreactivity for αA-crystallin, but photoreceptor apoptosis was noted where expression of αA-crystallin was relatively low. The present study demonstrated that αA-crystallin was up-regulated in the cytoplasm of photoreceptors in the SO retina. This may play a protective role in the suppression of photoreceptor apoptosis associated with intraocular inflammation.

Published
2012
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31. Human anterior chamber angle development without cell death or macrophage involvement.

Author

Meghpara B, Li X, Nakamura H, Khan A, Bejjani BA, Lin S, and Edward DP

Subjects
Adult, Aged, Antigens, CD metabolism, Antigens, Differentiation, Myelomonocytic metabolism, Cell Death, Cell Nucleus metabolism, Fetus cytology, Fetus embryology, Fluoresceins, Humans, Immunohistochemistry, In Situ Nick-End Labeling, Indoles, Macrophages metabolism, Middle Aged, Anterior Chamber cytology, Anterior Chamber embryology, Macrophages cytology
Abstract

Purpose: The iridocorneal angle in the mammalian eye including the trabecular meshwork (TM) develops from undifferentiated mesenchyme/neural crest between the iris root and cornea. The precise mechanisms underlying anterior angle development are unclear, and the contribution of cell death and phagocytic resorption by macrophages in angle development is controversial. In this study, we examined the human anterior chamber angle during various stages of development for evidence of cell death and phagocytic resorption., Methods: Eyes from the human fetus (F) of 7, 8, 9, 10, 11, 13, 15, 18, 19, 21, 22, 23, and 27 weeks as well as eyes from 5- and 11-month-old children and donors 24, 48, and 67 years of age were obtained. Formalin-fixed and paraffin-embedded sections were examined by hematoxylin and eosin (H&E) staining. Immunohistochemistry was performed using polyclonal antibodies against CD68. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) labeling was also performed to evaluate cell death., Results: By light microscopy, the development of human angle structures appeared to progress as previously described. Histological evidence of cellular death or resorption by macrophages was not observed. Furthermore, the chamber angle tissues did not stain with CD68 at any stage of development. Few CD68 positive cells were observed in the iris stroma and the anterior ciliary body between fetal weeks 10 and 18 (F10w and F18w). TUNEL labeled nuclei were not detected in the anterior chamber angle in any fetal or infant eyes. By contrast, TUNEL positive nuclei in TM cells were observed in the examined adult donor specimens., Conclusions: The results suggest that at the time points examined, neither cell death nor phagocytic resorption with macrophages appear to play a role in the development of the human anterior chamber angle.

Published
2008

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