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Your search keyword '"Megha Tawate"' showing total 13 results
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13 results on '"Megha Tawate"'

2. Clinical Dose Preparation of [177Lu]Lu-DOTA-Pertuzumab Using Medium Specific Activity [177Lu]LuCl3 for Radioimmunotherapy of Breast and Epithelial Ovarian Cancers, with HER2 Receptor Overexpression

Author

Sreeja Raj Menon, Arpit Mitra, Avik Chakraborty, Megha Tawate, Sudeep Sahu, Sutapa Rakshit, Sujay Gaikwad, Geetanjali Dhotre, Archana Damle, and Sharmila Banerjee

Subjects
Pharmacology, Cancer Research, Oncology, Radiology, Nuclear Medicine and imaging, General Medicine
Published
2022
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3. Automated radiochemical synthesis of pharmaceutical grade [ 18 F]FLT using 3‐N‐Boc‐5′‐O‐dimethoxytrityl‐3′‐O‐nosyl‐thymidine precursor and its Sep‐Pak® purification employing selective elution from reversed phase

Author

Arpit Mitra, Avik Chakraborty, Trupti Upadhye, Megha Tawate, Sangita Lad, Sudeep Sahu, Chinagandham Rajesh, Swati Bagul, Yogita Pawar, Mukti Kant Ray, and Sharmila Banerjee

Subjects
Organic Chemistry, Drug Discovery, Radiology, Nuclear Medicine and imaging, Biochemistry, Spectroscopy, Analytical Chemistry
Published
2022
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4. Therapeutic Multidose Preparation of a Ready-to-Use 177Lu-PSMA-617 Using Carrier Added Lutetium-177 in a Hospital Radiopharmacy and Its Clinical Efficacy

Author

Sudip Sahoo, Sharmila Banerjee, Sangita Lad, Arpit Mitra, Sujay Gaikwad, Sutapa Rakshit, Hemant Shimpi, Megha Tawate, Sandip Basu, and Avik Chakraborty

Subjects
Pharmacology, Oncology, Cancer Research, medicine.medical_specialty, 177Lu-PSMA-617, business.industry, General Medicine, Prostate carcinoma, urologic and male genital diseases, Clinical study, Internal medicine, medicine, Ready to use, Radiology, Nuclear Medicine and imaging, Clinical efficacy, business, Membrane antigen
Abstract

Introduction: [177Lu]Lu-prostate-specific membrane antigen (PSMA)-617 has emerged as a promising radiopharmaceutical for targeting PSMA in metastatic castrate-resistant prostate carcinoma (mCRPC). ...

Published
2021
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5. On the production of pharmaceutical grade indium-111-chloride in the medical cyclotron from natural cadmium target and its use in formulation of diagnostic patient dose of 111In-pentetreotide for imaging somatostatin receptor overexpression

Author

Megha Tawate, Avik Chakraborty, Kanchan Kushwaha, Arpit Mitra, Milan Kumar Dey, Biju Keshavkumar, Ashis K. Satpati, Sangita Lad, Rahul Bhoite, Sharmila Banerjee, and Trupti Upadhye

Subjects
Cadmium, Chemistry, Somatostatin receptor, Health, Toxicology and Mutagenesis, Radiochemistry, Cyclotron, Public Health, Environmental and Occupational Health, chemistry.chemical_element, 010403 inorganic & nuclear chemistry, 01 natural sciences, Pollution, Chloride, 0104 chemical sciences, Analytical Chemistry, law.invention, Column chromatography, Nuclear Energy and Engineering, law, 111In-Pentetreotide, medicine, Radiology, Nuclear Medicine and imaging, Patient dose, Spectroscopy, Indium, medicine.drug
Abstract

A prototype, semi-automated, indigenous solid-target assembly has been developed to produce clinical grade 111InCl3 from natCd targets. Fluka Monte Carlo code was used to estimate the optimum proton energy range for 111Cd(p,n)111In production route and suitable decay time to get high specific-activity of 111In. The radiochemical purification and separation have been optimized using column chromatography separation method. The quality of 111InCl3 has been established by radiolabeling of Pentetreotide yielding 111In-Pentetreotide, in acceptable radiochemical purity (RCP), with expected biological efficacy in in-vitro and in-vivo models. Pre-clinical translation of 111InCl3 in formulation of 111In-Pentetreotide adds support toward its use as a clinical grade radiochemical.

Published
2021
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6. On the Separation of Yttrium-90 from High-Level Liquid Waste: Purification to Clinical-Grade Radiochemical Precursor, Clinical Translation in Formulation of90Y-DOTATATE Patient Dose

Author

Sharmila Banerjee, Arpit Mitra, Megha Tawate, Trupti Upadhye, Sudip Sahoo, Sangita Lad, Sujay Gaikwad, Rahul V. Parghane, Poonam Jagesia, Avik Chakraborty, Sreeja Menon, P.S. Dhami, and Sandip Basu

Subjects
Pharmacology, Cancer Research, Materials science, Radiochemistry, 90Y-DOTATATE, chemistry.chemical_element, Clinical grade, General Medicine, Yttrium, Liquid waste, Oncology, chemistry, Radiology, Nuclear Medicine and imaging, Patient dose, Control parameters
Abstract

Introduction: The quality control parameters of in-house-produced 90Y-Acetate from high-level liquid waste (HLLW) using supported liquid membrane (SLM) technology were validated and compared with t...

Published
2021
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7. Clinical Dose Preparation of [

Author

Sreeja Raj, Menon, Arpit, Mitra, Avik, Chakraborty, Megha, Tawate, Sudeep, Sahu, Sutapa, Rakshit, Sujay, Gaikwad, Geetanjali, Dhotre, Archana, Damle, and Sharmila, Banerjee

Subjects
Ovarian Neoplasms, Radioisotopes, Receptor, ErbB-2, Breast Neoplasms, Carcinoma, Ovarian Epithelial, Lutetium, Radioimmunotherapy, Trastuzumab, Antibodies, Monoclonal, Humanized, Heterocyclic Compounds, 1-Ring, Mice, Animals, Humans, Female, Tissue Distribution, Radiopharmaceuticals
Published
2022

8. Automated radiochemical synthesis of pharmaceutical grade [

Author

Arpit, Mitra, Avik, Chakraborty, Trupti, Upadhye, Megha, Tawate, Sangita, Lad, Sudeep, Sahu, Chinagandham, Rajesh, Swati, Bagul, Yogita, Pawar, Mukti Kant, Ray, and Sharmila, Banerjee

Subjects
Receptors, Cell Surface, Dideoxynucleosides, Mice, Inbred C57BL, Mice, Pharmaceutical Preparations, Immunoglobulin G, Neoplasms, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Animals, Tissue Distribution, Rabbits, Radiopharmaceuticals, Thymidine
Abstract

Pharmaceutical grade 3'-deoxy-3'-[

Published
2022

10. Therapeutic Multidose Preparation of a Ready-to-Use

Author

Avik, Chakraborty, Arpit, Mitra, Megha, Tawate, Sudip, Sahoo, Sangita, Lad, Sutapa, Rakshit, Sujay, Gaikwad, Sandip, Basu, Hemant, Shimpi, and Sharmila, Banerjee

Subjects
Glutamate Carboxypeptidase II, Male, Radioisotopes, Mice, Nude, Dose-Response Relationship, Radiation, Radiotherapy Dosage, Dipeptides, Lutetium, Prostate-Specific Antigen, Xenograft Model Antitumor Assays, Heterocyclic Compounds, 1-Ring, Mice, Prostatic Neoplasms, Castration-Resistant, Clinical Protocols, Cell Line, Tumor, Antigens, Surface, Animals, Humans, Tissue Distribution, Neoplasm Metastasis, Radiopharmaceuticals
Published
2021

11. In vitro study of 177Lu-DOTA-Trastuzumab and 177Lu-DOTA-Pertuzumab for evaluation of binding affinity towards human cell lines with differential expression of HER-2 receptor

Author

Megha Tawate, Avik Chakraborty, Arpit Mitra, Sangeeta Lad, Sujay Gaikwad, Sudeep Sahu, Trupti Upadhye, Sutapa Rakshit, Sreeja Menon, Mukti Kant Ray, Archana Damle, and Sharmila Banerjee

Subjects
Cancer Research, Molecular Medicine, Radiology, Nuclear Medicine and imaging
Published
2022
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