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In the face of the global COVID-19 pandemic, the over-the-top service of new generic media continues its unbelievable flight. The availability of content, easy access to various shows, ease of use, and continuity of shows require users to subscribe to OTT video streaming. This study aims to pinpoint the factors that show the consequences & growth of OTT over the traditional medium and the effect of the consequences of the OTT platform on gender & occupation. With a sample size of 200, the data was gathered from primary sources utilizing convenience sampling and a semi-structured questionnaire. The data was analyzed by using factor analysis & ANOVA. Two main factors used in were Consequences of OTT (Factor 1) and OTT growth over traditional medium (Factor 2). The variations in factors 1 & 2 were 42.59 & 15.49 respectively. As per factor analysis, factor 1 was the most important and the Cronbach alpha values of 0.852 and 0.807 respectively, reveal the reliability of the two factors. Also, Analysis of Variance (ANOVA) shows that gender & occupation have a significant effect on the consequences of the OTT platform. The online consumption of content was also found to have several negative effects on the life style of the respondents.

A high capacitance of 1039 F g−1 for Co3O4 as compared to 527 F g−1 for CoFe2O4 along with a capacity retention of 86% for up to GCD 5000 cycles, confirm it's potential to be used as an electrode for practical energy storage devices.

In this study extent of impact that urban women leaders can assert in urban local political dynamics was analyzed. The study sought to gain an insight into what impact their political representation and leadership styles had on the affiliated self-governing institutions and grassroot governance in last 75 years of Independence. This study thus presents an exhaustive review of the studies of how the urban grassroots were empowered with imbibing gender equality at grassroots through increasing political representation and leadership of women, the challenges further and suggest a direction for future developments. Based on the analysis, now is the present to focus on women's leadership in decision making institutions from mere representation or allegiance to women's empowerment for a logical concatenation. Having more women leaders with transformational leadership style in urban self-governing institutions will have a ripple effect on not only improving grassroot democracies but also bridging the gender gap to meet the sustainable developmental goal gender equality target by 2030, by imbibing inclusivity and shifting focus towards issues of priority and social development. Further, a theoretical and practical implications of the results are discussed. Directions for future studies could focus on the development of motivators to empower urban women leaders in urban India.

Background: The term "hyperglycemia" is derived from the Greek hyper (top) + glykys (sugar/sugar) + haima (blood). Extra sugar varies from one hundred and twenty-five mg / dL and is faster and more noticeable than one hundred and eighty mg / metric unit a couple of hours after meals. The patient has decreased resistance to aldohexose, or prediabetes, with rapid plasma aldohexose 100 mg / dL one hundred and twenty-five mg / dL. The patient is diagnosed with diabetes mellitus, more noticeable than one hundred and twenty-five mg / metric dose units. As long as the symptom is not treated, it will create a variety of dangerous complications that include pain in the care, kidneys, nerves, heart, and vascular structure. Objectives: To define the number of children in the past to assess whether symptoms have been given or not and whether this is often associated with a PIM pair difficulty index. Methods: Recurrent analysis, patients between one month and fifteen years The World Health Organization recognizes care for septic shock, between the month of the Gregorian calendar 2008 and Oct 2010. -aldohexose> 126 mg / dl. Patients were diagnosed according to age, gender, illness, and glucose levels when treated, 24, forty-eight, and seventy-two hrs Results: Out of 25 patients, 16 PF had symptoms, one patient had a glucose level> 200 mg /dl, and only one patient needed a hypoglycemic agent, usually between seventy-two hours and admission. Conclusions: The World Health Organization's gift of septic shock occurs at a lower rate, and people have developed the World Health Organization, a self-administered gift of traditional blood sugar levels of 72 hours while not requiring hypoglycemic agent administration. Patients with symptoms had a higher mortality rate of PIM pairs, thus increasing mortality.

Cyclin dependent kinase 2 (CDK2) is an established target protein for therapeutic intervention in various diseases, including cancer. Reported inhibitors of CDK2 target the ATP-binding pocket to inhibit the kinase activity. Many small molecule CDK2 inhibitors have been discovered and their crystal structure with CDK2 or CDK2/Cyclin A complex have been published. NU6140 is a CDK2 inhibitor with moderate potency and selectivity. Herein we report the co-crystal structure determination of NU6140 in complex with CDK2 and confirmation of the binding using various biophysical methods. Our data shows that NU6140 bind to CDK2 with a Kd of 800 nM as determined by SPR and stabilizes the protein against thermal denaturation (ΔTm- 5 ℃). The co-crystal structure determined in our study shows that NU6140 binds in the ATP binding pocket as expected for this class of compounds and interacts with Leu83 and Glu81 with regular hydrogen bonds and with Asp145 via water mediated H-bond. Based on these data, we propose structural modifications of NU6140 to introduce new interactions with CDK2 that can improve its potency while retaining the selectivity.

Partial unilateral lentiginosis (PUL) is a rare pigmentary disorder that is characterized by multiple clustered lentigens on a normal skin in a segmental pattern with a sharp demarcation at the midline. Heterochromia is a condition of the eye in which there is variation in iris colour of one or both eyes. There has been multiple associations of PUL and has also been associated with ocular involvement but has never been associated with heterochromia. Herein we report an undocumented association of PUL with central heterochromia.

OBJECTIVES: To assess the role of sialendoscopy as a diagnostic modality and in managing cases of non-neoplastic parotid gland diseases. Secondly, to provide descriptive analysis of intraoperative findings. METHODS: The patients of chronic parotid sialadenitis who presented with complaints of recurrent unilateral or bilateral parotid swelling and pain were included in the study. All patients underwent sialendoscopy, and the findings were noted. Intervention was carried out in the same sitting like dilatation of stenosis, stone removal by basket, combined approach, flushing of mucoid flakes, etc. Failed cases were worked up with radiological investigation and managed accordingly. RESULTS: Two hundred and forty-one cases of parotid sialadenitis who underwent sialendoscopy between 2012 and 2018 were included. Diagnostic sialendoscopy was achieved in 100% cases, while intervention was successful in 96.7% (233/241) cases after the first procedure. On diagnostic sialendoscopy, ductal stenosis was the most common pathology present in 177 (73.4%) patients followed by stones (12%) and debris (11.6%). All cases of stenosis were serially dilated with increasing sizes of sialendoscopes followed by stenting in 75% of the cases. The diagnosis of juvenile recurrent parotitis was confirmed in 17 children (mean age 5.6 years) with consistent clinical history and sialendoscopic findings of stenosis along with pale ductal mucosa. There were 18 cases where ductal perforation was seen. One case showed multiple hyperdense foci in bilateral parotid gland along with multiple strictures that underwent repeat sialendoscopy, but the symptoms did not resolve, and finally the patient underwent bilateral superficial parotidectomy. CONCLUSION: Sialendoscopy is a safe and highly effective modality in managing non-neoplastic parotid gland disorders with low complication rates and resulted in gland preservation in the vast majority of patients. Therefore, it can be concluded that sialendoscopy is the diagnostic and therapeutic modality of choice for parotid obstructive sialadenitis.

In this paper a natural question which arise to study the graphical aspect of split $$(n+t)$$ -color partitions, is answered by introducing a new class of lattice paths, called split lattice paths. A direct bijection between split $$(n+t)$$ -color partitions and split lattice paths is proved. This new combinatorial object is applied to give new combinatorial interpretations of two basic functions of Gordon-McIntosh. Some generalized q-series are also discussed. We further explore these paths by providing combinatorial interpretations of some Rogers-Ramanujan type identities which reveal their rich structure and great potential for further research.

Five mock theta functions of S. Ramanujan are combinatorially interpreted by means of certain associated lattice path functions and antihook differences. These results provide new combinatorial interpretations of five mock theta functions of Ramanujan. Using a bijection between the associated lattice path functions and the $(n+t)$-color partitions and then between the associated lattice path functions and the weighted lattice path functions, we extend the works by Agarwal and Agarwal and Rana to five new 3-way combinatorial identities. These results are further extended to 4-way combinatorial identities by using bijection between the $(n+t)$-color partitions and the partitions with certain antihook differences. These interesting results present elegant combinatorial links between Ramanujan's mock theta functions, $(n+t)$-color partitions, weighted lattice paths, associated lattice paths, and antihook differences.

The aim of this paper is to present our experience with intraoral approach for submandibular gland excision in terms of effectiveness and safety in patients with chronic sialadenitis. This is a prospective study carried out from November, 2016 to April, 2018 analyzing 13 patients of chronic sialadenitis. The indication of intraoral approach was either failed attempt to remove the stone endoscopically, chronic sialadenitis or benign tumor. The surgical triangle was used as the landmark for hilar area and gland was dissected close to the capsule and removed via intraoral incision and preserving the sublingual gland. We were successfully able to remove the submandibular gland via intraoral approach in 10 cases. Two patients had to undergo transcervical gland excision and one patient refused for transcervical approach. Intraoral excision of submandibular gland is a safe and viable approach to be utilized in carefully selected patients. The major advantages being avoidance of transcervical scar and of injury to marginal mandibular branch of facial nerve.

The calcium chalcogenides belong to an important class of semiconductor materials. It comprises a large band gap which enables its use in applications of luminescent devices, so they are of technological and scientific interest. These compounds are found in NaCl (B1) and CsCl (B2) crystallographic phase. In the current work, structural properties of calcium chalcogenides have been studied to understand their phase stability. Here, these properties are computed by applying the plane wave pseudopotential method employing a generalized gradient approximation (GGA) of the density functional theory (DFT). In addition to this an effort is also made to plot the phonon density of state (PDOS) and phonon dispersion spectra of this compound to understand the phonon behavior and are compared with other calculated results.

The present study was conducted to investigate the factors influencing food ordering on Zomato in Hisar region of Haryana. A survey was conducted on 100 respondents by using questionnaire as research instrument through online mode. Pie charts were plotted for studying behavior of demographic characters and bar diagrams were used for finding the influence of factors under study. The validity & reliability of a questionnaire measuring an attitude and attitude related aspects was tested with exploratory factor analysis and Cronbach’s alpha The factor analysis with thirteen observed variables (i.e., survey question responses) that was summarized in terms of two factors with Cronbach alpha values .930 & .902. Cronbach alpha for both the factors was greater than 0.9, hence questionnaire was reliable and strength of factor 1 was more with higher value of Cronbach alpha. It is concluded that offers, price, quality of food and delivery charges was effective variables with high factor loading.

With the rapid advancement in technology, penetration of smart phones and increase in levels of affordable internet facilities resulted in the rise of OTT media services. OTT platforms gives freedom to their users to watch T.V. series, movies, etc.at their own convenience. The study was conducted to find out the factors influencing consumer’s choice of streaming OTT platforms. Convenience sampling technique was used for the study and response from 200 respondents (students, working people/ staff, homemakers and entrepreneurs), was collected in Hisar city, through semi-structured questionnaire. The variations in the factors (Growth, Benefits of OTT, Integrated marketing and communication) were 41.321, 6.621, 5.977, and 5.378 per cent, respectively. As per factor analysis, all four factors were most important that influenced consumers’ choice of streaming OTT services, and the Cronbach alpha values were 0.844, 0.812, 0.798, and 0.629, respectively.

In the last few decades, varieties of semiconductors have been explored for electronic and thermoelectric applications. As a result of these motivations, the current research work investigates the structural, electronic, vibrational, elastic, mechanical, thermodynamic, and thermoelectric properties of two quaternary Heuslers (QHs), namely LiHfCoGe and LiHfCoSn (both of which are semiconducting in nature), within the computational framework of DensityFunctional Theory (DFT) and Boltzmann transport equations. Both alloys display the p-type semiconductivity, dynamical stability and crystallize in the FCC cubic structure within F-43 m space group. The high Seebeck coefficient values pronounce an excellent and fundamental thermoelectric character. The large melting points expose their scope in the high-temperature regions. However, all of the thermoelectric characteristics are also measured in terms of the estimated relaxation time using deformation potential theory. Even though the figure of merit (ZT) is in the middle of the pack yet better than many compounds of the same sort. The impact of spin–orbit coupling on the thermoelectric characteristics is also examined. The practical utilization of the materials can be evaluated from the elastic and mechanical properties that are favorable in manufacturing efficient and reliable Thermoelectric Modules at high-temperatures.

We give the generating function of split$(n+t)$-colour partitions and obtain an analogue of Euler’s identity for split$n$-colour partitions. We derive a combinatorial relation between the number of restricted split$n$-colour partitions and the function$\unicode[STIX]{x1D70E}_{k}(\unicode[STIX]{x1D707})=\sum _{d|\unicode[STIX]{x1D707}}d^{k}$. We introduce a new class of split perfect partitions with$d(a)$copies of each part$a$and extend the work of Agarwal and Subbarao [‘Some properties of perfect partitions’,Indian J. Pure Appl. Math 22(9) (1991), 737–743].

To compare median change in morning peak expiratory flow rate (PEFR) and clinical asthma control in children receiving total daily dosage of inhaled budesonide administered either as once-daily or divided twice-daily dose. It was a randomized, parallel group, open label, noninferiority trial on 80 children aged 5–12 y with mild or moderate well-controlled asthma. Baseline parameters were recorded and subjects received inhaled budesonide either as once-daily or divided twice-daily dose. Primary outcome was median change in morning PEFR. Secondary outcomes included median change in evening and diurnal variation in PEFR, asthma symptom control as per Global Initiative for Asthma, 2017 and Asthma Control Questionnaire, and spirometric measurements taken at the clinic. The median [interquartile range (IQR)] increase in morning PEFR was more in children receiving once-daily as compared to those receiving twice-daily inhaled budesonide (by 6:00 L/min; IQR: −44.00–63.00 L/min vs. 4:00 L/min; IQR: −67.50–67.50 L/min, p 0.222; 95% CI: −1.37 to 19.08). Other spirometric variables and symptoms scores were also nonsignificant except median change in evening PEFR which was in favor of twice-daily regimen. Once-daily administration of inhaled budesonide is noninferior to twice-daily administration of equivalent daily dosage of inhaled budesonide.

In the present work we explore the electronic, vibrational and thermoelectric properties of new Li based quaternary Heusler compound LiYNiSn that is recently proposed by Jiangang He et.al. [Chem. Mater. 30 (2018) 4978] which is based on the 18-electron rule. Here the theoretical calculations are performed within the approach of density functional theory and semi classical Boltzmann transport equations with the constant relaxation time approximation. The band gap of the proposed compound is 0.38 eV that is in agreement with the available results in literature. The Seebeck coefficient and the Figure of Merit (ZT) are calculated at the three different temperatures (300K, 600K and 700K) with respect to the chemical potential (μ). The maximum ZT recorded is 0.14 at 700 K temperature. The compound is reported first time as the thermoelectric material and can be beneficial in the experimental research of thermoelectrical materials.

A simple and template-free one-pot solvothermal method is developed to grow hierarchical mesoporous Li3VO4 (HM-Li3VO4) on graphene oxide (GO). The growth of nutshell-shaped Li3VO4 on GO with nutshell sizes ranging from 2 micrometres to sub-micrometre levels and a multimodal mesopore hierarchy lead to enhanced electrical and ionic conductivity of HM-Li3VO4-GO as compared to that of HM-Li3VO4 or non-porous solid-state prepared Li3VO4 alone. The composite material shows a charge capacity of 559 mAh g−1 at 0.1 C for the first cycle and a discharge capacity of 414 mAh g−1 at 0.5 C in the second cycle between 0.2 and 3 V. Furthermore, discharge capacity of 374 mAh g−1 achieved at 0.5 C in the fifth cycle is comparable or superior to those reported for other Li3VO4 samples with similar carbon contents. The superior anode performance is attributed to its mesopore hierarchy and attachment with GO.

BackgroundColonoscopy screenings are the most valuable tool in preventing colorectal mortalities. The traditional technique uses air-insufflation, but water-infusion is a newer colonoscopy technique which is rapidly becoming standard of care, as it may decrease patient discomfort and the need for analgesics and anesthetics. Research is still ongoing as to the comparability of detection rates between the two techniques. The purpose of this study was to determine if training residents in underwater colonoscopies is more effective than training them in traditional air-insufflation colonoscopies.MethodsThis study was a retrospective, single-institution study that compared the patient-related and procedure-related variables of 183 colonoscopies performed by two cohorts of physicians. In the first cohort, the gastroenterologist with a resident trainee performed an air colonoscopy. In the second, the gastroenterologist and resident trainee performed an underwater colonoscopy.ResultsFor patient-related variables, there was no significant difference in age, previous abdominal surgeries, or bowel preparation. There were more females in the underwater group, which is significant as females tend to be harder to scope due to the increased tortuosity of their colon. For procedural outcomes, there was no significant difference in adenoma detection rate, cecal intubation rate, or procedural complications (hypotension, bradycardia). On average, the water colonoscopies required less midazolam and fentanyl, although they did have a longer procedural time.ConclusionsOverall, these findings suggest that training residents in underwater colonoscopies may increase patient comfort and decrease complications with comparable success rates.

Immunoglobulin G4-related disease (IgG4-RD) is a chronic multisystem immune-mediated disease. Histologically, it presents as infiltration with IgG4-secreting plasma cells affecting many organs such as the pancreas, lacrimal glands, salivary glands, kidneys, and arteries, resulting in chronic fibrosis and scarring within the tissue which over time forms into a mass. It is a slow-growing process that usually remains indolent until it causes a mass effect or tissue infiltration. Our patient was found to have a pancreatic mass on imaging concerning pancreatic neoplastic lesions. He subsequently underwent biopsy for histology/pathology and IgG4 levels, which led to our diagnosis of IgG4-RD. Imaging, blood tests, and, most importantly, histopathological features of the involved organ are important in determining the diagnosis. This is important as a treatment plan will be based on the given diagnosis, and patients with IgG4-RD respond very well to systemic steroid therapy.

Antiperovskite materials have wide range of applications because of their unusual technological applications. An analysis of structural and electronic properties of Ca3PbO in cubic inverse perovskite phase has been made using first principle density functional theory (DFT). Exchange and correlation effects are taken into account by a generalized gradient approximation (GGA). The structural properties including the lattice constant, the bulk modulus and the pressure derivative of bulk modulus are calculated. The results of our calculations are in good agreement with other experimental and theoretical results. In addition to this, the band gap is also computed by plotting electronic band structure.

The structural, elastic and mechanical properties of HfO2 in cubic phase have been calculated by using first principle density functional theory (DFT). We have employed the plane wave pseudo-potential method within a generalized gradient approximation (GGA) to compute all these properties. The exchange correlation function chosen is norm conserving Perdew–Burke–Ernzerhof (PBE) functional. The present calculated results are in good agreement with other theoretical and experimental results. Beside all this, ductility of crystal is also proved by calculating Cauchy’s pressure and Pugh’s index (B/G). Moreover, the vibrational properties of c-HfO2 are investigated by plotting phonon dispersion curve and phonon density of states (PDOS) for the first time.

Heusler compounds are a tuneable class of material with a cubic crystal structure that can serve as a platform to study the topological phase of a material. These materials have numerous technological and scientific applications. So, in the present work, the mechanical, thermodynamical, and thermoelectric properties of LaAuPb in the topological phase have been reported by using density functional theory and Boltzmann transport theory. LaAuPb is mechanically stable, and the Poisson ratio reveals its ductile nature. The specific heat of the proposed compound at room temperature is 73.94 J K−1 mol−1 at constant volume. Debye’s temperature is estimated to be 188.64 K. Moreover, the lattice thermal conductivity of the compound is 14.64 W mK−1 and 3.66 W mK−1 at 300 K and 1200 K, respectively. The good thermoelectric response of LaAuPb can be confirmed by its high value of the figure of merit (0.46) at 1200 K. Hence, it is a potential material for thermoelectric applications. This work will help future researchers to better understand the stability, nature, and behavior of LaAuPb in material fabrication.

The objective of this study is to analyze oncological outcomes for treatment of Tis and T1 glottic squamous cell carcinoma after transoral laser microsurgery. This study is retrospective analysis of previously untreated, suspected lesion of glottis, staged cT1a and cT1b squamous cell carcinoma in a tertiary care hospital and 53 patients were included in the study. End points for analysis were local control, overall and disease specific survival rates. The local control, ultimate local control with laser alone, 3-year overall survival, 3-year disease specific survival and organ preservation rates were 86.7, 90.5, 92.4, 98.1 and 98.1% respectively. The involvement of anterior commissure did not show any significant impact on local control or survival. TLM is safe and effective treatment of early glottis cancer, associated with less morbidity and a high percentage of local control, survival and organ preservation rates.

Background: The impact of COVID-19 on healthcare services has resulted in significant changes in day to day practice in order to reduce the virus transmission and protect the public and the healthcare professionals. Rhinologists are at higher risk of contracting the virus as they are regularly exposed to the aerosols generated during out-patient and surgical procedures. The aim of the survey was to identify the impact of COVID-19 on various aspects of rhinology practice and the changes instituted to mitigate the risks.Methods: An anonymous email survey was developed and circulated among otolaryngologists from around the world. Results: A total of 162 responses from 44 countries were included in the analysis. 63% of the respondents attended only emergent, urgent and time sensitive cases in the outpatient setting with introduction of various screening methods. Over 88% respondents were carrying out aerosol-generating procedures (AGPs) in their rhinology clinics. 67.39% respondents had not operated on any COVID-19 positive patient at the completion of the survey. Preoperative COVID testing and self-solation protocols differed as per the local hospital policy. 16 rhinologists reported a member of their team becoming positive after AGPs and 9 becoming positive after being involved in surgical procedures. Online teaching sessions were the most preferred (74.38%) mode of continued medical teaching/ training around the world.Conclusions: Data analysis revealed that most rhinologists followed the suggested guidelines by various ear, nose and throat (ENT) national organisations like ENTUK, the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) etc. in their practice and also provided insight into some of the deficiencies which need improvement as the pandemic continues to affect the global practice.

CD73 is a cell surface ectoenzyme, which is overexpressed in many types of human and mouse cancers. CD73 is the primary enzymatic producer of immunosuppressive adenosine in the tumor microenvironment, and high CD73 expression is associated with significantly poorer prognosis in several tumor types. Inhibition of either adenosine generation or signaling by inhibiting CD73 have been shown to be effective therapeutic approaches. Here we sought to discover and develop novel and orally bioavailable small molecule inhibitors that target CD73. Aurigene's non-nucleotide small molecule exhibit potent inhibition of CD73 in respective biochemical and cellular assays. High potency translated into rescue of AMP induced repression of IFN-Υ and IL-2 in human PBMCs. Lead compounds exhibited desirable drug-like properties including solubility, Caco2 permeability, lack of CYP inhibition and excellent oral pharmacokinetic exposure. In summary, we have identified small molecule inhibitors with good drug like properties, which showed good in vitro potency and excellent PK. Evaluation of these lead compounds in syngeneic tumor model along with in vivo toxicity studies are currently under way. Citation Format: Chandregowda Venkateshappa, Kishore Narayanan, Prasath Kothandaraman, Garima Priyadarshani, Rashmi Nair, Megha Goyal, Vijay Kamal Ahuja, Sagar Dadhania, AB Aravind, DS Samiulla, Girish Daginakkatte, Thomas Antony, Kavitha Nellore, Sunil Panigrahi, Dinesh Chikkanna, Susanta Samajdar, Murali Ramachandra. Novel, potent and orally bioavailable small molecule CD73 inhibitors for cancer immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1713.

Background: SMARCA2 (BRM) and SMARCA4 (BRG1) are two mutually exclusive DNA-dependent ATPases of the SWI/SNF complex, which function in mobilizing nucleosomes to regulate transcription, DNA replication/repair and chromosome dynamics. SMARCA4 is known to be mutated in number of cancers lacking targetable oncogenes, with SMARCA4-mutant patient population representing 10%-20% of NSCLC, 100% small cell ovarian cancer (hypercalcemic type), 28% skin cancer, 16% glioma and 14% colon cancer. Genetic studies have established the necessity of SMARCA2 for survival of tumor cells lacking SMARCA4. Although genetic silencing of SMARCA2 leads to potent anti-proliferative activity in SMARCA4-deficient cancer cell lines, pharmacological studies with a probe capable of binding to SMARCA2 and SMARCA4 bromodomains have failed to recapitulate such anti-proliferative effects. This prompted us to evaluate targeted protein degradation as an alternate approach to target SMARCA4 altered cancers. Methods and Results: A variety of hetero bi-functional molecules were synthesized by conjugating selective SMARCA2/4 bromodomain inhibitors with either VHL or CRBN E3-ligase specific ligands. Rational design approach guided by our proprietary ternary complex modeling algorithm, ALMOND (ALgorithm for MOdeling Neosubstrate Degraders) resulted in the identification of highly selective SMARCA2 degraders. The lead compound, AU-19820 showed > 10000-fold selectivity for SMARCA2 degradation versus other homologous proteins in tested cell lines. AU-19820 demonstrated potent anti-proliferative activity in SMARCA4 mutant but not in SMARCA2/4 proficient cell lines. This compound displayed favorable IV PK profile in rodents along with clean CYP profile. Additionally, the lead compound exhibited significant tumor growth inhibition in RERF-LC-A1 (SMARCA4 mutant lung cancer) xenograft model when dosed via i.v. route. Efficacious exposures were well tolerated with excellent tumor penetration. The compound also demonstrated moderate oral bioavailability in mouse. Efforts are in progress to improve this further by SAR modifications and exploiting prodrug approach. Conclusions: Potent and extremely selective SMARCA2 protein degraders were identified by conjugating SMARCA2/4 inhibitors with known VHL or CRBN ligands. SMARCA2 vs SMARCA4 selectivity handles have been very well explored with expandable SAR. Lead compound also displayed a synthetic lethality phenotype in SMARCA4 mutant cancer models while sparing SMARCA2/4 proficient ones. Further optimization of the oral bioavailability and evaluation of efficacy through oral route as well as intermittent IV dosing are planned. Citation Format: Chandrasekhar Abbineni, Leena Khare Satyam, Bilash Kuila, Ashok Ettam, Khaji Abdul Rawoof, Sreevidya MR, Sandeep Vitthal Dukare, Suraj T. Gore, Rakesh P. Nankar, Vijay Kamal Ahuja, Charamanna KB, Megha Goyal, Kiran Aithal, Samiulla DS, Subhendu Mukherjee, Thomas Antony, Sanjeev Giri, Shekar Chelur, Kavitha Nellore, Girish Daginakatte, Murali Ramachandra, Susanta Samajdar. Orally bioavailable SMARCA2 degraders with exceptional selectivity and potency [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1144.