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3. First-in-human demonstration of floating EMG sensors and stimulators wirelessly powered and operated by volume conduction

Author

Becerra-Fajardo, Laura, Minguillon, Jesus, Krob, Marc Oliver, Rodrigues, Camila, González-Sánchez, Miguel, Megía-García, Álvaro, Galán, Carolina Redondo, Henares, Francisco Gutiérrez, Comerma, Albert, del-Ama, Antonio J., Gil-Agudo, Angel, Grandas, Francisco, Schneider-Ickert, Andreas, Barroso, Filipe Oliveira, and Ivorra, Antoni

Published
2024
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5. Pilotaje de un procedimiento de farmacovigilancia

Author

Hidalgo Sotelo T, Cuéllar Rodríguez S, Megía Arias C, Varas Doval R, Martín Gutiérrez L, and Torres Fernández A

Subjects
Farmacovigilancia, acontecimiento adverso, tarjeta amarilla., Pharmacy and materia medica, RS1-441
Abstract

El farmacéutico, como profesional especialista del medicamento, desempeña un papel central en el campo de la farmacovigilancia, especialmente si se considera que su actuación profesional cubre tanto el campo de la medicina humana como de la medicina veterinaria. Tanto en el ámbito comunitario como en el hospitalario, la disponibilidad profesional y la actuación centrada específicamente en el medicamento favorecen el cumplimiento de las obligaciones de farmacovigilancia.

Published
2009

6. First-in-human demonstration of floating EMG sensors and stimulators wirelessly powered and operated by volume conduction

Author

Laura Becerra-Fajardo, Jesus Minguillon, Marc Oliver Krob, Camila Rodrigues, Miguel González-Sánchez, Álvaro Megía-García, Carolina Redondo Galán, Francisco Gutiérrez Henares, Albert Comerma, Antonio J. del-Ama, Angel Gil-Agudo, Francisco Grandas, Andreas Schneider-Ickert, Filipe Oliveira Barroso, and Antoni Ivorra

Subjects
Wireless power transfer, Volume conduction, AIMDs, Bidirectional communications, Electromyography, Sensor, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Background Recently we reported the design and evaluation of floating semi-implantable devices that receive power from and bidirectionally communicate with an external system using coupling by volume conduction. The approach, of which the semi-implantable devices are proof-of-concept prototypes, may overcome some limitations presented by existing neuroprostheses, especially those related to implant size and deployment, as the implants avoid bulky components and can be developed as threadlike devices. Here, it is reported the first-in-human acute demonstration of these devices for electromyography (EMG) sensing and electrical stimulation. Methods A proof-of-concept device, consisting of implantable thin-film electrodes and a nonimplantable miniature electronic circuit connected to them, was deployed in the upper or lower limb of six healthy participants. Two external electrodes were strapped around the limb and were connected to the external system which delivered high frequency current bursts. Within these bursts, 13 commands were modulated to communicate with the implant. Results Four devices were deployed in the biceps brachii and the gastrocnemius medialis muscles, and the external system was able to power and communicate with them. Limitations regarding insertion and communication speed are reported. Sensing and stimulation parameters were configured from the external system. In one participant, electrical stimulation and EMG acquisition assays were performed, demonstrating the feasibility of the approach to power and communicate with the floating device. Conclusions This is the first-in-human demonstration of EMG sensors and electrical stimulators powered and operated by volume conduction. These proof-of-concept devices can be miniaturized using current microelectronic technologies, enabling fully implantable networked neuroprosthetics.

Published
2024
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7. Consumption of health resources in older people with differentiated thyroid carcinoma: a multicenter analysis

Author

Díez, Juan J., Anda, Emma, Alcazar, Victoria, Isidro, María L., Familiar, Cristina, Paja, Miguel, Martín Rojas-Marcos, Patricia, Pérez-Corral, Begoña, Navarro, Elena, Romero-Lluch, Ana R., Oleaga, Amelia, Pamplona, María J., Fernández-García, José C., Megía, Ana, Manjón-Miguélez, Laura, Sánchez-Ragnarsson, Cecilia, Iglesias, Pedro, and Sastre, Julia

Published
2023
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17. Contributions of each of the four swimming strokes to elite 200-400 individual medley swimming performance in short and long course competitions

Author

José María González-Ravé, Jesus Santos-Cerro, Patricia González-Megía, and David Pyne

Subjects
Performance, Data analysis, Swimming, Competitions, Tactics, Mentoring, Medicine, Biology (General), QH301-705.5
Abstract

Objectives The relative contribution of each of the four strokes to performance, and whether these contributions differ substantially between short course and long course competitions is unclear. To clarify these issues the aim of this study was to assess the strokes that have more influence on the performance in the 200 and 400 m IM swimming performances of elite male and female swimmers, participating in major events: Olympic Games (OG) and World Championship (WC) in short-course and long-course from 2012 to 2021. Methods Data from 1,095 swimmers (501 women and 594 men) who competed in 200 and 400-m IM were obtained with a minimum level of 800 FINA points. Linear regression modelling and classification trees were employed to quantify differences between strokes and short/long course swimming. Results Regression analysis indicated that breaststroke (β = − 0.191; p

Published
2023
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20. Exoskeleton-based training improves walking independence in incomplete spinal cord injury patients: results from a randomized controlled trial

Author

Ángel Gil-Agudo, Álvaro Megía-García, José Luis Pons, Isabel Sinovas-Alonso, Natalia Comino-Suárez, Vicente Lozano-Berrio, and Antonio J. del-Ama

Subjects
Neurological rehabilitation, Spinal cord injury, Robotic exoskeleton, Walking, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Background In recent years, ambulatory lower limb exoskeletons are being gradually introduced into the clinical practice to complement walking rehabilitation programs. However, the clinical evidence of the outcomes attained with these devices is still limited and nonconclusive. Furthermore, the user-to-robot adaptation mechanisms responsible for functional improvement are still not adequately unveiled. This study aimed to (1) assess the safety and feasibility of using the HANK exoskeleton for walking rehabilitation, and (2) investigate the effects on walking function after a training program with it. Methods A randomized controlled trial was conducted including a cohort of 23 patients with less than 1 year since injury, neurological level of injury (C2-L4) and severity (American Spinal Cord Injury Association Impairment Scale [AIS] C or D). The intervention was comprised of 15 one-hour gait training sessions with lower limb exoskeleton HANK. Safety was assessed through monitoring of adverse events, and pain and fatigue through a Visual Analogue Scale. LEMS, WISCI-II, and SCIM-III scales were assessed, along with the 10MWT, 6MWT, and the TUG walking tests (see text for acronyms). Results No major adverse events were reported. Participants in the intervention group (IG) reported 1.8 cm (SD 1.0) for pain and 3.8 (SD 1.7) for fatigue using the VAS. Statistically significant differences were observed for the WISCI-II for both the “group” factor (F = 16.75, p

Published
2023
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34. Differentiated thyroid carcinoma in the elderly: influence of age on disease-free and overall survival

Author

Díez, Juan J., Anda, Emma, Alcazar, Victoria, Isidro, María L., Familiar, Cristina, Paja, Miguel, Rojas Marcos, Patricia, Pérez-Corral, Begoña, Navarro, Elena, Romero-Lluch, Ana R., Oleaga, Amelia, Pamplona, María J., Fernández-García, José C., Megía, Ana, Manjón, Laura, Sánchez-Ragnarsson, Cecilia, Iglesias, Pedro, and Sastre, Julia

Published
2022
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35. High-speed dual color fluorescence lifetime endomicroscopy for highly-multiplexed pulmonary diagnostic applications and detection of labeled bacteria

Author

Pedretti, Ettore, Tanner, Michael G., Choudhary, Tushar R., Krstajic, Nikola, Megia--Fernandez, Alicia, Henderson, Robert K., Bradley, Mark, Thomson, Robert R., Girkin, John M., Dhaliwal, Kev, and Dalgarno, Paul A.

Subjects
Physics - Medical Physics
Abstract

We present a dual color laser scanning endomicroscope capable of fluorescence lifetime endomicroscopy at one frame per second (FPS). The scanning system uses a coherent imaging fiber with 30,000 cores. High-speed lifetime imaging is achieved by distributing the signal over an array of 1024 parallel single-photon avalanche photo--diode detectors (SPADs), minimizing detection dead time maximizing the number of photons detected per excitation pulse without photon pile--up to achieve the high frame rate. Dual color fluorescence imaging is achieved by temporally shifting the dual excitation lasers, with respect to each other, to separate the two spectrally distinct fluorescent decays. Combining the temporal encoding, to provide spectral separation, with lifetime measurements we show a one FPS, multi-channel endomicroscopy platform for clinical applications and diagnosis. We demonstrate the potential of the system by imaging smartprobe-labeled bacteria in ex vivo samples of human lung using lifetime to differentiate bacterial fluorescence from the strong background lung auto--fluorescence which was used to provide structural information.

Published
2018

36. High fidelity fibre-based physiological sensing deep in tissue

Author

Choudhary, Tushar R., Tanner, Michael G., Megia-Fernandez, Alicia, Harrington, Kerrianne, Wood, Harry A., Marshall, Adam, Zhu, Patricia, Chankeshwara, Sunay V., Choudhury, Debaditya, Monro, Graham, Ucuncu, Muhammed, Yu, Fei, Duncan, Rory R., Thomson, Robert R., Dhaliwal, Kevin, and Bradley, Mark

Subjects
Physics - Medical Physics
Abstract

Physiological sensing deep in tissue, remains a clinical challenge. Here a flexible miniaturised sensing optrode providing a platform to perform minimally invasive in vivo in situ measurements is reported. Silica microspheres covalently coupled with a high density of ratiometrically configured fluorophores were deposited into etched pits on the distal end of a 150 micron diameter multicore optical fibre. With this platform, multiplexed photonic measurements of pH and oxygen concentration with high precision in the distal alveolar space of the lung is reported. We demonstrated the phenomenon that high-density deposition of carboxyfluorescein covalently coupled to silica microspheres shows an inverse shift in fluorescence in response to varying pH. This platform delivered fast and accurate measurements, near instantaneous response time, no photobleaching, immunity to power fluctuations and a flexible architecture for addition of multiple sensors.

Published
2018

38. Effectiveness of mRNA vaccine boosters against infection with the SARS-CoV-2 omicron (B.1.1.529) variant in Spain: a nationwide cohort study

Author

Moreno, David, Méndez Díaz, Manuel, Huerta González, Ismael, Galmés Truyols, Antònia, Barreno Estévez, Ana, García Velasco, Valvanuz, Rodríguez Recio, Mª Jesús, Sacristán, José, Martínez Marcos, Montserrat, Pastor Villalba, Eliseo, Macías Ortiz, María José, García Vallejo, Ana, Sánchez Gómez, Amaya, García Pina, Rocío, Barricarte Gurea, Aurelio, Sancho Martínez, Rosa, Ochoa, Eva María, Vázquez Cantero, Mauricio, Gómez Anés, Atanasio, Pareja Megía, María Jesús, Castán, Yolanda, Fonseca Álvarez, Manuel Roberto, Salvà Fiol, Antonia, Sánchez Janáriz, Hilda, López Arce, Luz, Cisneros Martín, María Ángeles, Gibernau, Frederic Jose, Fernandez Buey, Cesar, Villatoro Bongiorno, Katja, Rubio García, Francisco Javier, Santos Guerra, Fernando, Astray Mochales, Jenaro, Francisco Verdu, Francisco Javier, García Romero, Isabel, Oriza Bernal, Rosa, Gómez Pérez, Tomás, Hijano Villegas, Salomé, Román Soto, Sergio, Gómez-Barroso, Diana, Lapeña, María Fé, Yagüe Galaup, Virgilio, Alfaro Latorre, Mercedes, Aguilera Guzmán, Marta, Crespo Sánchez-Eznarriaga, Belén, Neira León, Montserrat, Cívicos Villa, Noemí, Monge, Susana, Rojas-Benedicto, Ayelén, Olmedo, Carmen, Mazagatos, Clara, José Sierra, María, Limia, Aurora, Martín-Merino, Elisa, Larrauri, Amparo, and Hernán, Miguel A

Published
2022
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45. javis

Author

Megía, Carlos

Subjects
Ambrossi, Javi -- Actitudes, García, Macarena, Calvo, Javi -- Actitudes
Abstract

En este número javis Más allá del plural de sus nombres, y mientras celebran una década de éxito meteórico, la pareja compuesta por Javi Ambrossi y Javi Calvo regresa a [...]

Published
2023

47. Environmental factors influence cross-talk between a heat shock protein and an oxidative stress protein modification in the lizard Gallotia galloti

Author

Gilbert, Edward, primary, Žagar, Anamarija, additional, López-Darias, Marta, additional, Megía-Palma, Rodrigo, additional, Lister, Karen A., additional, Jones, Max Dolton, additional, Carretero, Miguel A., additional, Serén, Nina, additional, Beltran-Alvarez, Pedro, additional, and Valero, Katharina C. Wollenberg, additional

Published
2024
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50. Transcranial direct current stimulation combined with robotic therapy for upper and lower limb function after stroke: a systematic review and meta-analysis of randomized control trials

Author

Natalia Comino-Suárez, Juan C. Moreno, Julio Gómez-Soriano, Álvaro Megía-García, Diego Serrano-Muñoz, Julian Taylor, Mónica Alcobendas-Maestro, Ángel Gil-Agudo, Antonio J. del-Ama, and Juan Avendaño-Coy

Subjects
Transcranial direct current stimulation, tDCS, Robotic, Neuromodulation, Stroke, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Background Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation method able to modulate neuronal activity after stroke. The aim of this systematic review was to determine if tDCS combined with robotic therapy (RT) improves limb function after stroke when compared to RT alone. Methods A search for randomized controlled trials (RCTs) published prior to July 15, 2021 was performed. The main outcome was function assessed with the Fugl-Meyer motor assessment for upper extremities (FM/ue) and 10-m walking test (10MWT) for the lower limbs. As secondary outcomes, strength was assessed with the Motricity Index (MI) or Medical Research Council scale (MRC), spasticity with the modified Ashworth scale (MAS), functional independence with the Barthel Index (BI), and kinematic parameters. Results Ten studies were included for analysis (n = 368 enrolled participants). The results showed a non-significant effect for tDCS combined with RT to improve upper limb function [standardized mean difference (SMD) = − 0.12; 95% confidence interval (CI): − 0.35–0.11)]. However, a positive effect of the combined therapy was observed in the lower limb function (SMD = 0.48; 95% CI: − 0.15–1.12). Significant results favouring tDCS combined with RT were not found in strength (SMD = − 0.15; 95% CI: − 0.4–0.1), spasticity [mean difference (MD) = − 0.15; 95% CI: − 0.8–0.5)], functional independence (MD = 2.5; 95% CI: − 1.9–6.9) or velocity of movement (SMD = 0.06; 95% CI: − 0.3–0.5) with a “moderate” or “low” recommendation level according to the GRADE guidelines. Conclusions Current findings suggest that tDCS combined with RT does not improve upper limb function, strength, spasticity, functional independence or velocity of movement after stroke. However, tDCS may enhance the effects of RT alone for lower limb function. tDCS parameters and the stage or type of stroke injury could be crucial factors that determine the effectiveness of this therapy.

Published
2021
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