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1. Consumption of health resources in older people with differentiated thyroid carcinoma: a multicenter analysis

Author

Díez, Juan J., Anda, Emma, Alcazar, Victoria, Isidro, María L., Familiar, Cristina, Paja, Miguel, Martín Rojas-Marcos, Patricia, Pérez-Corral, Begoña, Navarro, Elena, Romero-Lluch, Ana R., Oleaga, Amelia, Pamplona, María J., Fernández-García, José C., Megía, Ana, Manjón-Miguélez, Laura, Sánchez-Ragnarsson, Cecilia, Iglesias, Pedro, and Sastre, Julia

Published
2023
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3. Differentiated thyroid carcinoma in the elderly: influence of age on disease-free and overall survival

Author

Díez, Juan J., Anda, Emma, Alcazar, Victoria, Isidro, María L., Familiar, Cristina, Paja, Miguel, Rojas Marcos, Patricia, Pérez-Corral, Begoña, Navarro, Elena, Romero-Lluch, Ana R., Oleaga, Amelia, Pamplona, María J., Fernández-García, José C., Megía, Ana, Manjón, Laura, Sánchez-Ragnarsson, Cecilia, Iglesias, Pedro, and Sastre, Julia

Published
2022
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4. Recovery of parathyroid function in patients with thyroid cancer treated by total thyroidectomy: An analysis of 685 patients with hypoparathyroidism at discharge of surgery

Author

Díez, Juan J., Anda, Emma, Sastre, Julia, Pérez-Corral, Begoña, Álvarez-Escolá, Cristina, Manjón, Laura, Paja, Miguel, Sambo, Marcel, Santiago-Fernández, Piedad, Blanco-Carrera, Concepción, Galofré, Juan C., Navarro, Elena, Zafón, Carles, Sanz, Eva, Oleaga, Amelia, Bandrés, Orosia, Donnay, Sergio, Megía, Ana, Picallo, María, Sánchez-Ragnarsson, Cecilia, Baena-Nieto, Gloria, Fernández-García, José Carlos, Lecumberri, Beatriz, Vega, Manel Sahún de la, Romero-Lluch, Ana R., and Iglesias, Pedro

Published
2021
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6. Prevalence and risk factors for hypoparathyroidism following total thyroidectomy in Spain: a multicentric and nation-wide retrospective analysis

Author

Díez, Juan J., Anda, Emma, Sastre, Julia, Pérez Corral, Begoña, Álvarez-Escolá, Cristina, Manjón, Laura, Paja, Miguel, Sambo, Marcel, Santiago Fernández, Piedad, Blanco Carrera, Concepción, Galofré, Juan C, Navarro, Elena, Zafón, Carles, Sanz, Eva, Oleaga, Amelia, Bandrés, Orosia, Donnay, Sergio, Megía, Ana, Picallo, María, Sánchez Ragnarsson, Cecilia, Baena-Nieto, Gloria, García, José Carlos Fernández, Lecumberri, Beatriz, de la Vega, Manel Sahún, Romero-Lluch, Ana R., and Iglesias, Pedro

Published
2019
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7. Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery

Author

Ejarque, Miriam, Borlaug, Marianne, Vilarrasa, Nuria, Martinez-Perez, Bruno, Llauradó, Gemma, Megía, Ana, Helland, Thomas, Gutierrez, Cristina, Serena, Carolina, Folkestad, Oddry, Nuñez-Roa, Catalina, Roche, Kelly, Casajoana, Ana, Fradera, Rosa, González-Clemente, José Miguel, López, Miguel, Mohn, Arne C., Nedrebø, Bjørn G., Nogueiras, Ruben, Mellgren, Gunnar, Fernø, Johan, Fernández-Veledo, Sonia, and Vendrell, Joan

Published
2017
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10. The Gut Microbiota Metabolite Succinate Promotes Adipose Tissue Browning in Crohn’s Disease

Author

Monfort-Ferré, Diandra, Caro, Aleidis, Menacho, Margarita, Marti-Gallostra, Marc, Espina, Beatriz, Boronat-Toscano, Albert, Núñez Roa, Catalina, Seco, Jesús, Bautista, Michelle, Espín, Eloy, Megía, Ana, Vendrell, Joan, Fernández-Veledo, Sonia, Serena, Carolina, Universitat Autònoma de Barcelona, Institut Català de la Salut, [Monfort-Ferré D, Boronat-Toscano A] Hospital Universitari de Tarragona Joan XXIII, Institut d’Investigació Sanitària Pere Virgili, Tarragona, Spain. CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain. [Caro A, Espina B] Colorectal Surgery Unit, Hospital Universitari Joan XXIII, Tarragona, Spain. [Menacho M] Digestive Unit, Hospital Universitari Joan XXIII, Tarragona, Spain. [Martí M, Espín E] Unitat de Cirurgia de Còlon i Recte, Servei de Cirurgia General, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
fenómenos microbiológicos::microbiota::microbiota intestinal [FENÓMENOS Y PROCESOS], Microbiological Phenomena::Microbiota::Gastrointestinal Microbiome [PHENOMENA AND PROCESSES], Adipose Tissue, White, Creeping fat, Succinic Acid, Gastroenterology, Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases::Crohn Disease [DISEASES], Bacteria translocation, General Medicine, Crohn, Malaltia de, Beige adipose tissue, enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::enfermedad inflamatoria intestinal::enfermedad de Crohn [ENFERMEDADES], Gastrointestinal Microbiome, Succinic acid, Teixit adipós, Tissues::Connective Tissue::Adipose Tissue [ANATOMY], SUCNR1, Crohn Disease, Adipose Tissue, Humans, Intestins - Microbiologia, tejidos::tejido conectivo::tejido adiposo [ANATOMÍA], Uncoupling Protein 1
Abstract

Succinic acid; Bacteria translocation; Beige adipose tissue Àcid succínic; Translocació de bacteris; Teixit adipós beige Ácido succínico; Translocación de bacterias; Tejido adiposo beige Background and Aims Crohn’s disease [CD] is associated with complex microbe–host interactions, involving changes in microbial communities, and gut barrier defects, leading to the translocation of microorganisms to surrounding adipose tissue [AT]. We evaluated the presence of beige AT depots in CD and questioned whether succinate and/or bacterial translocation promotes white-to-beige transition in adipocytes. Methods Visceral [VAT] and subcutaneous [SAT] AT biopsies, serum and plasma were obtained from patients with active [n = 21] or inactive [n = 12] CD, and from healthy controls [n = 15]. Adipose-derived stem cells [ASCs] and AT macrophages [ATMs] were isolated from VAT biopsies. Results Plasma succinate levels were significantly higher in patients with active CD than in controls and were intermediate in those with inactive disease. Plasma succinate correlated with the inflammatory marker high-sensitivity C-reactive protein. Expression of the succinate receptor SUCNR1 was higher in VAT, ASCs and ATMs from the active CD group than from the inactive or control groups. Succinate treatment of ASCs elevated the expression of several beige AT markers from controls and from patients with inactive disease, including uncoupling protein-1 [UCP1]. Notably, beige AT markers were prominent in ASCs from patients with active CD. Secretome profiling revealed that ASCs from patients with active disease secrete beige AT-related proteins, and co-culture assays showed that bacteria also trigger the white-to-beige switch of ASCs from patients with CD. Finally, AT depots from patients with CD exhibited a conversion from white to beige AT together with high UCP1 expression, which was corroborated by in situ thermal imaging analysis. Conclusions Succinate and bacteria trigger white-to-beige AT transition in CD. Understanding the role of beige AT in CD might aid in the development of therapeutic or diagnostic interventions. This study was supported by grants from the Spanish Ministry of Science and Innovation [PI18/00037 (Instituto de Salud Carlos III, ISCIII) to C.S.; PI17/01503 and PI20/00338 (ISCIII) to J.V. and RTI2018-093919 to S.F.-V.], co-financed by the European Regional Development Fund [ERDF] and a European Crohn’s and Colitis Organization grant to C.S. The Spanish Biomedical Research Center in Diabetes and Associated Metabolic Disorders [CIBERDEM] [CB07708/0012] is an initiative of the Instituto de Salud Carlos ISCIII acknowledges support from the ‘Ramón y Cajal’ programme from the Ministerio de Educación y Ciencia [RYC2013-13186], co-financed by the ERDF. S.F.-V. acknowledge support from the ‘Miguel Servet’ tenure track programme [CP10/00438, CPII16/0008] from the Fondo de Investigación Sanitaria, co-financed by the ERDF. D.M.-F. acknowledges support from PERIS-PFI-Salut SLT01720000021.

Published
2022

11. The ANGPTL3-4-8 Axis in Normal Gestation and in Gestational Diabetes, and Its Potential Involvement in Fetal Growth

Author

Klid, Sergiy, primary, Maymó-Masip, Elsa, additional, Algaba-Chueca, Francisco, additional, Ballesteros, Mónica, additional, Inglès-Puig, Montserrat, additional, Guarque, Albert, additional, Madeira, Ana, additional, Jareño, Carlos, additional, Vendrell, Joan, additional, Fernández-Veledo, Sonia, additional, and Megía, Ana, additional

Published
2023
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12. Consumption of health resources in older people with differentiated thyroid carcinoma: a multicenter analysis

Author

Díez, Juan J., primary, Anda, Emma, additional, Alcazar, Victoria, additional, Isidro, María L., additional, Familiar, Cristina, additional, Paja, Miguel, additional, Rojas-Marcos, Patricia Martín, additional, Pérez-Corral, Begoña, additional, Navarro, Elena, additional, Romero-Lluch, Ana R., additional, Oleaga, Amelia, additional, Pamplona, María J., additional, Fernández-García, José C., additional, Megía, Ana, additional, Manjón-Miguélez, Laura, additional, Sánchez-Ragnarsson, Cecilia, additional, Iglesias, Pedro, additional, and Sastre, Julia, additional

Published
2023
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14. Asistencia a la gestante con diabetes. Guía de práctica clínica actualizada en 2014

Author

Acosta, Domingo, Balsells, Montserrat, Ballesteros, Mónica, Bandres, Maria Orosia, Bartha, Jose Luis, Bellart, Jordi, Chico, Ana Isabel, Codina, Mercedes, Corcoy, Rosa, Cortázar, Alicia, Donnay, Sergio, González, Nieves Luisa, Goya, Maria del Mar, Herranz, Lucrecia, López, José, Megía, Ana, Moreno, Eduardo, Mozas, Juan, Ontañón, Marta, Perea, Verónica, Ramirez, Octavio, Rossell, M<ce:sup loc='post">a</ce:sup> Rosa, Rubio, José Antonio, Sancho, M<ce:sup loc='post">a</ce:sup> Antonia, Soldevila, Berta, and Vinagre, Irene

Published
2015
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15. Endocrine disruptors and Gestational Diabetes Mellitus: A pilot study of INSULIN cohort (Catalonia, Spain)

Author

Marquès, Montse, Gago-Ferrero, Pablo, Sánchez-Resino, Elena, Gil-Solsona, Ruben, Gutiérrez-Martín, Daniel, Taltavull, Núria, Inglés, Montserrat, Gómez, Raquel, Megía, Ana, Covaci, Adrian, and Domingo, José L.

Subjects
Endocrine disruptors, pregnancy, gestational diabetes mellitus, exposome, General Earth and Planetary Sciences, General Environmental Science
Abstract

BACKGROUND AND AIM: The incidence of Gestational Diabetes Mellitus (GDM) has increased in the past 20 years, and it is now diagnosed in up to 10% of all pregnancies. GDM is associated with adverse consequences like preeclampsia, birth complications, as well as with cardiometabolic diseases for both the mother and child. Many environmental factors can cause beta-cell stress, including the developmental exposure to Endocrine-Disrupting Chemicals (EDCs). The present pilot study was aimed at assessing the exposure to EDCs of pregnant women of INSULIN, a cohort of GDM built at Hospital Joan XXIII (Tarragona, Spain). METHODS: Sociodemographic, dietary and life-style determinants were linked to the occurrence of the EDCs and clinical data, including the development of GDM during pregnancy. The occurrence of BPA and 10 BPA analogues (BPF, BPS, BPAF, BPAP, BPB, BPE, BPG, BPM, BPP, BPZ), phthalates metabolites (mono-ethyl, mono-butyl and mono-methyl); parabens and their metabolites (methyl-, ethyl-, propyl- and butyl-); and flame-retardants (HBCD, TBBPA, TBP) were assessed in urine (12-week and delivery), mother serum (delivery), cord serum and/or placenta of 25 pregnant women by means of LC-QTOF. RESULTS: High detection rates of BPs, phthalate and parabens were found in urine and mother serum, but also their detection in placenta and cord serum, might be slightly related to the use of plastic and personal care products, along with the consumption of canned foodstuffs according to the results of the individual questionnaire. CONCLUSIONS: The premature state of the results does not allow identifying a potential role of a target EDC (or a mixture of EDCs) on the development of GDM. However, we can confirm the widespread presence of these EDCs in our daily life, which might become a hazard for the health of vulnerable population groups, such as pregnant women and their newborns.

Published
2022

20. Fasting Glucose for the Diagnosis of Gestational Diabetes Mellitus (GDM) during the COVID-19 Pandemic

Author

González González, Nieves Luisa, González Dávila, Enrique, Bugatto, Fernando, Vega Guedes, Begoña, Pintado Recarte, Pilar, Tascón, L., Villalba Martin, Nazaret, Plasencia, Walter, Megía, Ana, González González, Nieves Luisa, González Dávila, Enrique, Bugatto, Fernando, Vega Guedes, Begoña, Pintado Recarte, Pilar, Tascón, L., Villalba Martin, Nazaret, Plasencia, Walter, and Megía, Ana

Abstract

Background: During the COVID-19 pandemic, different non-validated tests were proposed to simplify the diagnosis of gestational diabetes (GDM). Aim: To analyse the effects of replacing the two-step approach for Early-GDM and GDM diagnosis, with a fasting plasma glucose test. Material and Methods: This is a cohort study consisting of 3200 pregnant women: 400 with Early-GDM, 800 with GDM and 2000 with Non-GDM diagnosed using the two-step approach. Using fasting plasma glucose for Early-GDM and GDM diagnosis, according to the recommendations of Spain, Australia, Italy and the UK during the pandemic, the rates of missed and new Early-GDM and GDM were calculated and perinatal outcomes were analysed. Results: Using fasting plasma glucose in the first trimester >100 mg/dL for Early-GDM diagnosis, the rates of post-COVID missed and new Early-GDM were 79.5% and 3.2%, respectively. Using fasting plasma glucose at 24–28 weeks <84 or >92, 95 or 100 mg/dL for GDM diagnosis, the rates of missed GDM were 50.4%, 78%, 82.6% and 92.4%, respectively, and 8.6%, 5.6% and 2.3% women with Non-GDM were diagnosed with new GDM. Conclusion: Fasting plasma glucose is not a good test for the diagnosis of GDM either in the first trimester or at 24–28 weeks., Depto. de Salud Pública y Materno - Infantil, Fac. de Medicina, TRUE, pub

Published
2022

22. Correction to: Prevalence and risk factors for hypoparathyroidism following total thyroidectomy in Spain: a multicentric and nation-wide retrospective analysis

Author

Díez, Juan J., Anda, Emma, Sastre, Julia, Pérez Corral, Begoña, Álvarez-Escolá, Cristina, Manjón, Laura, Paja, Miguel, Sambo, Marcel, Santiago Fernández, Piedad, Blanco Carrera, Concepción, Galofré, Juan Carlos, Navarro, Elena, Zafón, Carles, Sanz, Eva, Oleaga, Amelia, Bandrés, Orosia, Donnay, Sergio, Megía, Ana, Picallo, María, Sánchez Ragnarsson, Cecilia, Baena-Nieto, Gloria, Fernández García, José Carlos, Lecumberri, Beatriz, Sahún de la Vega, Manel, Romero-Lluch, Ana R., and Iglesias, Pedro

Published
2019
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23. Cord Blood Advanced Lipoprotein Testing Reveals an Interaction between Gestational Diabetes and Birth-Weight and Suggests a New Early Biomarker of Infant Obesity

Author

Algaba-Chueca, Francisco, primary, Maymó-Masip, Elsa, additional, Ballesteros, Mónica, additional, Guarque, Albert, additional, Majali-Martínez, Alejandro, additional, Freixes, Olga, additional, Amigó, Núria, additional, Fernández-Veledo, Sonia, additional, Vendrell, Joan, additional, and Megía, Ana, additional

Published
2022
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24. Changes in glucagon‐like peptide 1 and 2 levels in people with obesity after a diet‐induced weight‐loss intervention are related to a specific microbiota signature: A prospective cohort study

Author

Rodríguez‐Peña, M‐Mar, primary, Astiarraga, Brenno, additional, Seco, Jesus, additional, Ceperuelo‐Mallafré, Victoria, additional, Caballé, Adrià, additional, Pérez‐Brocal, Vicente, additional, Attolini, Camille Stephan‐Otto, additional, Moya, Andrés, additional, Llauradó, Gemma, additional, Megía, Ana, additional, Pellitero, Silvia, additional, Vilarrasa, Núria, additional, Fernández‐Veledo, Sonia, additional, and Vendrell, Joan, additional

Published
2021
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25. Correction: Late Recovery of Parathyroid Function after Total Thyroidectomy: A Case-Control Study

Author

Díez, Juan José, additional, Anda, Emma, additional, Sastre, Julia, additional, Corral, Begoña Pérez, additional, Álvarez-Escolá, Cristina, additional, Manjón, Laura, additional, Paja, Miguel, additional, Sambo, Marcel, additional, Fernández, Piedad Santiago, additional, Carrera, Concepción Blanco, additional, Galofré, Juan Carlos, additional, Navarro, Elena, additional, Zafón, Carles, additional, Sanz, Eva, additional, Oleaga, Amelia, additional, Bandrés, Orosia, additional, Donnay, Sergio, additional, Megía, Ana, additional, Picallo, María, additional, Ragnarsson, Cecilia Sánchez, additional, Baena-Nieto, Gloria, additional, Fernández-García, José Carlos, additional, Lecumberri, Beatriz, additional, de la Vega, Manel Sahún, additional, Romero-Lluch, Ana R., additional, and Iglesias, Pedro, additional

Published
2021
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26. Late Recovery of Parathyroid Function After Total Thyroidectomy: A Case-Control Study

Author

Díez, Juan José, additional, Anda, Emma, additional, Sastre, Julia, additional, Corral, Begoña Pérez, additional, Álvarez-Escolá, Cristina, additional, Manjón, Laura, additional, Paja, Miguel, additional, Sambo, Marcel, additional, Fernández, Piedad Santiago, additional, Carrera, Concepción Blanco, additional, Galofré, Juan Carlos, additional, Navarro, Elena, additional, Zafón, Carles, additional, Sanz, Eva, additional, Oleaga, Amelia, additional, Bandrés, Orosia, additional, Donnay, Sergio, additional, Megía, Ana, additional, Picallo, María, additional, Ragnarsson, Cecilia Sánchez, additional, Baena-Nieto, Gloria, additional, Fernández-García, José Carlos, additional, Lecumberri, Beatriz, additional, de la Vega, Manel Sahún, additional, Romero-Lluch, Ana R., additional, and Iglesias, Pedro, additional

Published
2021
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28. Gut Microbiota Metabolite Succinate Promotes Adipose Tissue Browning in Crohn's Disease.

Author

Monfort-Ferré, Diandra, Caro, Aleidis, Menacho, Margarita, Martí, Marc, Espina, Beatriz, Boronat-Toscano, Albert, Nuñez-Roa, Cati, Seco, Jesús, Bautista, Michelle, Espín, Eloy, Megía, Ana, Vendrell, Joan, Fernández-Veledo, Sonia, and Serena, Carolina

Abstract

Background and Aims Crohn's disease [CD] is associated with complex microbe–host interactions, involving changes in microbial communities, and gut barrier defects, leading to the translocation of microorganisms to surrounding adipose tissue [AT]. We evaluated the presence of beige AT depots in CD and questioned whether succinate and/or bacterial translocation promotes white-to-beige transition in adipocytes. Methods Visceral [VAT] and subcutaneous [SAT] AT biopsies, serum and plasma were obtained from patients with active [ n = 21] or inactive [ n = 12] CD, and from healthy controls [ n = 15]. Adipose-derived stem cells [ASCs] and AT macrophages [ATMs] were isolated from VAT biopsies. Results Plasma succinate levels were significantly higher in patients with active CD than in controls and were intermediate in those with inactive disease. Plasma succinate correlated with the inflammatory marker high-sensitivity C-reactive protein. Expression of the succinate receptor SUCNR1 was higher in VAT, ASCs and ATMs from the active CD group than from the inactive or control groups. Succinate treatment of ASCs elevated the expression of several beige AT markers from controls and from patients with inactive disease, including uncoupling protein-1 [UCP1]. Notably, beige AT markers were prominent in ASCs from patients with active CD. Secretome profiling revealed that ASCs from patients with active disease secrete beige AT-related proteins, and co-culture assays showed that bacteria also trigger the white-to-beige switch of ASCs from patients with CD. Finally, AT depots from patients with CD exhibited a conversion from white to beige AT together with high UCP1 expression, which was corroborated by in situ thermal imaging analysis. Conclusions Succinate and bacteria trigger white-to-beige AT transition in CD. Understanding the role of beige AT in CD might aid in the development of therapeutic or diagnostic interventions. [ABSTRACT FROM AUTHOR]

Published
2022
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30. Crohn's Disease Increases the Mesothelial Properties of Adipocyte Progenitors in the Creeping Fat

Author

Madeira, Ana, Serena, Carolina, Ejarque, Miriam, Maymó-Masip, Elsa, Millan, Monica, Navarro-Ruiz, M. Carmen, Guzmán-Ruiz, Rocío, Malagón, María M., Espin-Basany, Eloy, Martí, Marc, Menacho, Margarita, Megía, Ana, Vendrell, Joan, Fernández-Veledo, Sonia, Universitat Autònoma de Barcelona, Madeira, Ana, Serena, Carolina, Ejarque, Miriam, Maymó-Masip, Elsa, Millan, Monica, Navarro-Ruiz, M. Carmen, Guzmán-Ruiz, Rocío, Malagón, María M., Espin-Basany, Eloy, Martí, Marc, Menacho, Margarita, Megía, Ana, Vendrell, Joan, Fernández-Veledo, Sonia, and Universitat Autònoma de Barcelona

Abstract

Our understanding of the interplay between human adipose tissue and the immune system is limited. The mesothelium, an immunologically active structure, emerged as a source of visceral adipose tissue. After investigating the mesothelial properties of human visceral and subcutaneous adipose tissue and their progenitors, we explored whether the dysfunctional obese and Crohn's disease environments influence the mesothelial/mesenchymal properties of their adipocyte precursors, as well as their ability to mount an immune response. Using a tandem transcriptomic/proteomic approach, we evaluated the mesothelial and mesenchymal expression profiles in adipose tissue, both in subjects covering a wide range of body-mass indexes and in Crohn's disease patients. We also isolated adipose tissue precursors (adipose-derived stem cells, ASCs) to assess their mesothelial/mesenchymal properties, as well as their antigen-presenting features. Human visceral tissue presented a mesothelial phenotype not detected in the subcutaneous fat. Only ASCs from mesenteric adipose tissue, named creeping fat, had a significantly higher expression of the hallmark mesothelial genes mesothelin (MSLN) and Wilms' tumor suppressor gene 1 (WT1), supporting a mesothelial nature of these cells. Both lean and Crohn's disease visceral ASCs expressed equivalent surface percentages of the antigen-presenting molecules human leucocyte antigen-DR isotype (HLA-DR) and CD86. However, lean-derived ASCs were predominantly HLA-DR dim, whereas in Crohn's disease, the HLA-DR bright subpopulation was increased 3.2-fold. Importantly, the mesothelial-enriched Crohn's disease precursors activated CD4 + T-lymphocytes. Our study evidences a mesothelial signature in the creeping fat of Crohn's disease patients and its progenitor cells, the latter being able to present antigens and orchestrate an immune response

Published
2021

31. Changes in glucagon‐like peptide 1 and 2 levels in people with obesity after a diet‐induced weight‐loss intervention are related to a specific microbiota signature: A prospective cohort study

Author

Instituto de Salud Carlos III, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Generalitat Valenciana, European Commission, Rodríguez-Peña, M-Mar, Astiarraga, Brenno, Seco, Jesús, Ceperuelo-Mallafré, Victoria, Caballé, Adrià, Pérez-Brocal, Vicente, Stephan‐Otto Attolini, Camille, Moya, Andrés, Llauradó, Gemma, Megía, Ana, Pellitero, Silvia, Vilarrasa, Núria, Fernández‐Veledo, Sonia, Vendrell, Joan, Instituto de Salud Carlos III, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Generalitat Valenciana, European Commission, Rodríguez-Peña, M-Mar, Astiarraga, Brenno, Seco, Jesús, Ceperuelo-Mallafré, Victoria, Caballé, Adrià, Pérez-Brocal, Vicente, Stephan‐Otto Attolini, Camille, Moya, Andrés, Llauradó, Gemma, Megía, Ana, Pellitero, Silvia, Vilarrasa, Núria, Fernández‐Veledo, Sonia, and Vendrell, Joan

Published
2021

32. Crohn’s Disease Increases the Mesothelial Properties of Adipocyte Progenitors in the Creeping Fat

Author

Madeira, Ana, primary, Serena, Carolina, additional, Ejarque, Miriam, additional, Maymó-Masip, Elsa, additional, Millan, Monica, additional, Navarro-Ruiz, M. Carmen, additional, Guzmán-Ruiz, Rocío, additional, Malagón, María M., additional, Espin, Eloy, additional, Martí, Marc, additional, Menacho, Margarita, additional, Megía, Ana, additional, Vendrell, Joan, additional, and Fernández-Veledo, Sonia, additional

Published
2021
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36. Permanent postoperative hypoparathyroidism: an analysis of prevalence and predictive factors for adequacy of control in a cohort of 260 patients

Author

Díez, Juan J., primary, Anda, Emma, additional, Sastre, Julia, additional, Pérez Corral, Begoña, additional, Álvarez-Escolá, Cristina, additional, Manjón, Laura, additional, Paja, Miguel, additional, Sambo, Marcel, additional, Santiago Fernández, Piedad, additional, Blanco Carrera, Concepción, additional, Galofré, Juan C., additional, Navarro, Elena, additional, Zafón, Carles, additional, Sanz, Eva, additional, Oleaga, Amelia, additional, Bandrés, Orosia, additional, Donnay, Sergio, additional, Megía, Ana, additional, Picallo, María, additional, Sánchez Ragnarsson, Cecilia, additional, Baena-Nieto, Gloria, additional, Fernández-García, José Carlos, additional, Lecumberri, Beatriz, additional, Sahún de la Vega, Manel, additional, Romero-Lluch, Ana R., additional, and Iglesias, Pedro, additional

Published
2020
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37. Impaired succinate response to a mixed meal in obesity and type 2 diabetes is normalized after metabolic surgery

Author

Astiarraga, Brenno, primary, Martínez, Laia, primary, Ceperuelo-Mallafré, Victoria, primary, Llauradó, Gemma, primary, Terrón-Puig, Margarida, primary, Peña, M. Mar Rodríguez, primary, Casajoana, Anna, primary, Pellitero, Silvia, primary, Megía, Ana, primary, Vilarrasa, Núria, primary, Vendrell, Joan, primary, and Fernández-Veledo, Sonia, primary

Published
2020
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38. Gestational diabetes impacts fetal precursor cell responses with potential consequences for offspring

Author

Algaba-Chueca, Francisco, primary, Maymó-Masip, Elsa, additional, Ejarque, Miriam, additional, Ballesteros, Mónica, additional, Llauradó, Gemma, additional, López, Carlos, additional, Guarque, Albert, additional, Serena, Carolina, additional, Martínez-Guasch, Laia, additional, Gutiérrez, Cristina, additional, Bosch, Ramón, additional, Vendrell, Joan, additional, Megía, Ana, additional, and Fernández-Veledo, Sonia, additional

Published
2019
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39. Prevalence and risk factors for hypoparathyroidism following total thyroidectomy in Spain: a multicentric and nation-wide retrospective analysis

Author

Díez, Juan José, Anda, Emma, Sastre, Julia, Pérez Corral, Begoña, Álvarez-Escolá, Cristina, Manjón, Laura, Paja, Miguel, Sambo, Marcel, Santiago Fernández, Piedad, Blanco Carrera, Concepción, Galofré, J. C., Navarro-Villarán, Elena, Zafón, Carles, Sanz, Eva, Oleaga, Amelia, Bandrés, Orosia, Donnay, Sergio, Megía, Ana, Picallo, María, Sánchez Ragnarsson, Cecilia, Baena-Nieto, Gloria, Fernández-García, José C., Lecumberri, Beatriz, Sahún de la Vega, Manel, Romero-Lluch, Ana R., Iglesias, Pedro, Díez, Juan José, Anda, Emma, Sastre, Julia, Pérez Corral, Begoña, Álvarez-Escolá, Cristina, Manjón, Laura, Paja, Miguel, Sambo, Marcel, Santiago Fernández, Piedad, Blanco Carrera, Concepción, Galofré, J. C., Navarro-Villarán, Elena, Zafón, Carles, Sanz, Eva, Oleaga, Amelia, Bandrés, Orosia, Donnay, Sergio, Megía, Ana, Picallo, María, Sánchez Ragnarsson, Cecilia, Baena-Nieto, Gloria, Fernández-García, José C., Lecumberri, Beatriz, Sahún de la Vega, Manel, Romero-Lluch, Ana R., and Iglesias, Pedro

Abstract

[Purpose]: The prevalence of postoperative hypoparathyroidism has been studied in registries and in surgical series with highly variable and imprecise results. However, the frequency of this hormonal deficiency in the clinical practice of endocrinologists is not known with accuracy. We aimed to assess the prevalence and risk factors of hypoparathyroidism in patients undergoing total thyroidectomy in Spain. [Methods]: We designed a retrospective, multicentre and nation-wide protocol including all patients with total thyroidectomy who were seen in the endocrinology clinic of the participant centers from January to March 2018. Prevalence of hypoparathyroidism was evaluated at discharge of surgery, 3–6 months after surgery, 12 months after surgery and at last visit. Twenty hospitals participated in the study. [Results]: Of 1792 patients undergoing total thyroidectomy, 866 (48.3%) developed postoperative hypoparathyroidism at discharge of surgery. Most of them recover parathyroid function over time. Prevalence of hypoparathyroidism at 3–6 months, 12 months and at last visit was 22.9%, 16.7% and 14.5%, respectively. The risk of developing definitive hypoparathyroidism was related to the presence of parathyroid tissue at histology, lymph node dissection, and two-stage thyroidectomy. Patients with thyroid cancer, with higher postoperative calcium levels and treated by expert surgical teams exhibited lower risk of developing permanent hypoparathyroidism. [Conclusions]: Although most patients with postsurgical hypoparathyroidism recover parathyroid function, the prevalence of permanent disease in clinical practice is non negligible (14.5%). Postoperative calcium, extent and timing of surgery, the presence of cancer, expert surgical team, and parathyroid tissue at histology are predictors of permanent hypoparathyroidism.

Published
2019

40. SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity

Author

Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), European Commission, Instituto de Salud Carlos III, Keiran, Noelia, Ceperuelo-Mallafré, Victoria, Calvo, Enrique, Hernández-Alvarez, Maria Isabel, Ejarque, Miriam, Núñez-Roa, Catalina, Horrillo, Daniel, Maymó-Masip, Elsa, Rodríguez, M. Mar, Fradera, Rosa, Rosa, Juan Vladimir de la, Jorba, Rosa, Megía, Ana, Zorzano, Antonio, Medina, Gema, Serena, Carolina, Castrillo, Antonio, Vendrell, Joan, Fernández-Veledo, Sonia, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), European Commission, Instituto de Salud Carlos III, Keiran, Noelia, Ceperuelo-Mallafré, Victoria, Calvo, Enrique, Hernández-Alvarez, Maria Isabel, Ejarque, Miriam, Núñez-Roa, Catalina, Horrillo, Daniel, Maymó-Masip, Elsa, Rodríguez, M. Mar, Fradera, Rosa, Rosa, Juan Vladimir de la, Jorba, Rosa, Megía, Ana, Zorzano, Antonio, Medina, Gema, Serena, Carolina, Castrillo, Antonio, Vendrell, Joan, and Fernández-Veledo, Sonia

Abstract

Succinate is a signaling metabolite sensed extracellularly by succinate receptor 1 (SUNCR1). The accumulation of succinate in macrophages is known to activate a pro-inflammatory program; however, the contribution of SUCNR1 to macrophage phenotype and function has remained unclear. Here we found that activation of SUCNR1 had a critical role in the anti-inflammatory responses in macrophages. Myeloid-specific deficiency in SUCNR1 promoted a local pro-inflammatory phenotype, disrupted glucose homeostasis in mice fed a normal chow diet, exacerbated the metabolic consequences of diet-induced obesity and impaired adipose-tissue browning in response to cold exposure. Activation of SUCNR1 promoted an anti-inflammatory phenotype in macrophages and boosted the response of these cells to type 2 cytokines, including interleukin-4. Succinate decreased the expression of inflammatory markers in adipose tissue from lean human subjects but not that from obese subjects, who had lower expression of SUCNR1 in adipose-tissue-resident macrophages. Our findings highlight the importance of succinate-SUCNR1 signaling in determining macrophage polarization and assign a role to succinate in limiting inflammation.

Published
2019

41. Erratum. Preoperative Circulating Succinate Levels as a Biomarker for Diabetes Remission After Bariatric Surgery. Diabetes Care 2019;42:1956–1965

Author

Ceperuelo-Mallafré, Victoria, primary, Llauradó, Gemma, additional, Keiran, Noelia, additional, Benaiges, Ester, additional, Astiarraga, Brenno, additional, Martínez, Laia, additional, Pellitero, Silvia, additional, González-Clemente, Jose Miguel, additional, Rodríguez, Amaia, additional, Fernández-Real, José Manuel, additional, Lecube, Albert, additional, Megía, Ana, additional, Vilarrasa, Nuria, additional, Vendrell, Joan, additional, and Fernández-Veledo, Sonia, additional

Published
2019
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42. Arterial stiffness is highly correlated with the scores obtained from the Steno Type 1 Risk Engine in subjects with T1DM

Author

Llauradó, Gemma, primary, Cano, Albert, additional, Albert, Lara, additional, Ballesta, Silvia, additional, Mazarico, Isabel, additional, Luchtenberg, María-Florencia, additional, González-Sastre, Montserrat, additional, Megía, Ana, additional, Simó, Rafael, additional, Vendrell, Joan, additional, and González-Clemente, José-Miguel, additional

Published
2019
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43. Preoperative Circulating Succinate Levels as a Biomarker for Diabetes Remission After Bariatric Surgery

Author

Ceperuelo-Mallafré, Victoria, primary, Llauradó, Gemma, additional, Keiran, Noelia, additional, Benaiges, Ester, additional, Astiarraga, Brenno, additional, Martínez, Laia, additional, Pellitero, Silvia, additional, González-Clemente, Jose Miguel, additional, Rodríguez, Amaia, additional, Fernández-Real, José Manuel, additional, Lecube, Albert, additional, Megía, Ana, additional, Vilarrasa, Nuria, additional, Vendrell, Joan, additional, and Fernández-Veledo, Sonia, additional

Published
2019
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44. Mesothelial Origin of Creeping Fat Progenitors in Crohn's Disease

Author

Madeira, Ana, primary, Maymó-Masip, Elsa, additional, Serena, Carolina, additional, Millán, Mónica, additional, Navarro-Ruiz, M. Carmen, additional, Guzmán-Ruiz, Rocío, additional, Malagón, María M., additional, Megía, Ana, additional, Vendrell, Joan, additional, and Fernández-Veledo, Sonia, additional

Published
2019
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45. Impaired Succinate Response to a Mixed Meal in Obesity and Type 2 Diabetes Is Normalized After Metabolic Surgery.

Author

Astiarraga, Brenno, Martínez, Laia, Ceperuelo-Mallafré, Victoria, Llauradó, Gemma, Terrón-Puig, Margarida, Rodríguez, M. Mar, Casajoana, Anna, Pellitero, Silvia, Megía, Ana, Vilarrasa, Núria, Vendrell, Joan, and Fernández-Veledo, Sonia

Subjects
TYPE 2 diabetes, GASTRIC bypass, GLUCOSE tolerance tests, MORBID obesity, OBESITY, BARIATRIC surgery, INTRAVENOUS therapy
Abstract

Objective: To explore the meal response of circulating succinate in patients with obesity and type 2 diabetes undergoing bariatric surgery and to examine the role of gastrointestinal glucose sensing in succinate dynamics in healthy subjects.Research Design and Methods: Cohort I comprised 45 patients with morbid obesity and type 2 diabetes (BMI 39.4 ± 1.9 kg/m2) undergoing metabolic surgery. Cohort II was a confirmatory cohort of 13 patients (BMI 39.3 ± 1.4 kg/m2) undergoing gastric bypass surgery. Cohort III comprised 15 healthy subjects (BMI 26.4 ± 0.5 kg/m2). Cohorts I and II completed a 2-h mixed-meal tolerance test (MTT) before the intervention and at 1 year of follow-up, and cohort II also completed a 3-h lipid test (LT). Cohort III underwent a 3-h oral glucose tolerance test (OGTT) and an isoglycemic intravenous glucose infusion (IIGI) study.Results: In cohort I, succinate response to MTT at follow-up was greater than before the intervention (P < 0.0001). This response was confirmed in cohort II with a greater increase after 1 year of surgery (P = 0.009). By contrast, LT did not elicit a succinate response. Changes in succinate response were associated with changes in the area under the curve of glucose (r = 0.417, P < 0.0001) and insulin (r = 0.204, P = 0.002). In cohort III, glycemia, per se, stimulated a plasma succinate response (P = 0.0004), but its response was greater in the OGTT (P = 0.02; OGTT versus IIGI).Conclusions: The meal-related response of circulating succinate in patients with obesity and type 2 diabetes is recovered after metabolic surgery. [ABSTRACT FROM AUTHOR]

Published
2020
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47. Estudio descriptivo de las características del cáncer diferenciado de tiroides en Cataluña en el periodo 1998-2012. Registro CECaT

Author

Zafon, Carles, primary, Puig-Domingo, Manel, additional, Biarnés, Josefina, additional, Halperin, Irene, additional, Bella, Maria Rosa, additional, Castells, Ignasi, additional, González, Cintia, additional, Megía, Ana, additional, Santos, Lola, additional, García-Pascual, Luís, additional, Reverter, Jordi Lluís, additional, Pizarro, Eduarda, additional, and Mauricio, Dídac, additional

Published
2015
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