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11 results on '"Meessen, J.M.T.A."'

1. Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls

Author

Beekman, M., Suchiman, H.E.D., Deelen, J., Amin, N., Beulens, J.W., van der Bom, J.A., Bomer, N., Demirkan, A., van Hilten, J.A., Meessen, J.M.T.A., Pool, R., Moed, M.H., Fu, J., Onderwater, G.L.J., Rutters, F., So-Osman, C., van der Flier, W.M., van der Heijden, A.A.W.A., van der Spek, A., Asselbergs, F.W., Boersma, E., Elders, P.M., Geleijnse, J.M., Ikram, M.A., Kloppenburg, M., Meulenbelt, I., Mooijaart, S.P., Nelissen, R.G.H.H., Netea, M.G., Penninx, B.W.J.H., Stehouwer, C.D.A., Teunissen, C.E., Terwindt, G.M., ’t Hart, L.M., van den Maagdenberg, A.M.J.M., van der Harst, P., van der Horst, I.C.C., van der Kallen, C.J.H., van Greevenbroek, M.M.J., van Spil, W.E., Wijmenga, C., Zwinderman, A.H., Zhernikova, A., Jukema, J.W., Sattar, N., Bot, Mariska, Milaneschi, Yuri, Al-Shehri, Tahani, Amin, Najaf, Garmaeva, Sanzhima, Onderwater, Gerrit L.J., Pool, Rene, Thesing, Carisha S., Vijfhuizen, Lisanne S., Vogelzangs, Nicole, Arts, Ilja C.W., Demirkan, Ayse, van Duijn, Cornelia, van Greevenbroek, Marleen, van der Kallen, Carla J.H., Köhler, Sebastian, Ligthart, Lannie, van den Maagdenberg, Arn M.J.M., Mook-Kanamori, Dennis O., de Mutsert, Renée, Tiemeier, Henning, Schram, Miranda T., Stehouwer, Coen D.A., Terwindt, Gisela M., Willems van Dijk, Ko, Fu, Jingyuan, Zhernakova, Alexandra, Beekman, Marian, Slagboom, P. Eline, Boomsma, Dorret I., and Penninx, Brenda W.J.H.

Published
2020
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2. Higher thyroid stimulating hormone leads to cardiovascular disease and an unfavorable lipid profile: EVidence from multi-cohort Mendelian randomization and metabolomic profiling

Author

Van Vliet, N.A., primary, Bos, M.M., additional, Thesing, C.S., additional, Chaker, L., additional, Pietzner, M., additional, Houtman, E., additional, Neville, M.J., additional, Li-Gao, R., additional, Trompet, S., additional, Mustafa, R., additional, Ahmadizar, F., additional, Beekman, M., additional, Bot, M., additional, Budde, K., additional, Christodoulides, C., additional, Dehghan, A., additional, Delles, C., additional, Elliott, P., additional, Evangelou, M., additional, Gao, H., additional, Ghanbari, M., additional, Van Herwaarden, A.E., additional, Ikram, M.A., additional, Jaeger, M., additional, Jukema, J.W., additional, Karaman, I., additional, Karpe, F., additional, Kloppenburg, M., additional, Meessen, J.M.T.A., additional, Meulenbelt, I., additional, Milaneschi, Y., additional, Mooijaart, S.P., additional, Mook-Kanamori, D.O., additional, Netea, M.G., additional, Netea-Maier, R.T., additional, Peeters, R.P., additional, Penninx, B.W.J.H., additional, Sattar, N., additional, Slagboom, P.E., additional, Suchiman, H.E.D., additional, Völzke, H., additional, Van Dijk, K. Willems, additional, and Noordam, R., additional

Published
2021
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3. Correction to: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies (vol 11, 39, 2020)

Author

Hagenbeek, F.A., Pool, R., Dongen, J. van, Draisma, H.M., Hottenga, J.J., Willemsen, G., Abdellaoui, A., Fedko, I.O., Braber, A. den, Visser, P.J., Geus, E.J.C.N. de, Duijn, C.M. van, Harms, A.C., Bartels, M., Nivard, M.G., Boomsma, D.I., Hankemeier, T., Beulens, J.W., Rutters, F., Flier, W.M. van der, Hart, L.M., Bom, J.A. van der, Kloppenburg, M., Harst, P. van der, Bomer, N., Hilten, J.A. van, So-Osman, C., Meessen, J.M.T.A., Fu, J., Wijmenga, C., Zhernikova, A., Slofstra, M., Swertz, M., Onderwater, G.L.J., Terwindt, G.M., Heijden, A.A.W.A. van der, Asselbergs, F.W., Boersma, E., Elders, P.M., Geleijnse, J.M., Ikram, M.A., Mooijaart, S.P., Nelissen, R.G.H.H., Netea, M.G., Penninx, B.W.J.H., Stehouwer, C.D.A., Kallen, C.J.H. van der, Greevenbroek, M.M.J. van, Teunissen, C.E., Maagdenberg, A.M.J.M. van den, Spil, W.E. van, Zwinderman, A.H., Jukema, J.W., Mei, H., Akker, E.B. van den, Deelen, J., Horst I.C.C. van der, Reinders M.J.T., and Abdel Abdellaoui

Abstract

Correction to: Nature Communications https://doi.org/10.1038/s41467-019-13770-6, published online 7 January 2020.The original version of the Supplementary Information associated with this Article included an incorrect Supplementary Data 1 file, in which additional delimiters were included in the first column for a number of rows, resulting in column shifts for some of these rows. The HTML has been updated to include a corrected version of Supplementary Data 1; the original incorrect version of Supplementary Data 1 can be found as Supplementary Information associated with this Correction.

Published
2020

4. Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

Author

Hagenbeek, F.A., Pool, R., Dongen, J. van, Draisma, H.H.M., Hottenga, J.J., Willemsen, G., Abdellaoui, A., Fedko, I.O., Braber, A. den, Visser, P.J., Geus, E.J.C.N. de, Dijk, K.W. van, Verhoeven, A., Suchiman, H.E., Beekman, M., Slagboom, P.E., Duijn, C.M. van, Harms, A.C., Hankemeier, T., Bartels, M., Nivard, M.G., Boomsma, D.I., Wolf, J.J.H.B., Cats, D., Amin, N., Beulens, J.W., Bom, J.A. van der, Bomer, N., Demirkan, A., Hilten, J.A. van, Meessen, J.M.T.A., Moed, M.H., Fu, J., Onderwater, G.L.J., Rutters, F., So-Osman, C., Flier, W.M. van der, Heijden, A.A.W.A. van der, Spek, A. van der, Asselbergs, F.W., Boersma, E., Elders, P.M., Geleijnse, J.M., Ikram, M.A., Kloppenburg, M., Meulenbelt, I., Mooijaart, S.P., Nelissen, R.G.H.H., Netea, M.G., Penninx, B.W.J.H., Stehouwer, C.D.A., Teunissen, C.E., Terwindt, G.M., Hart, L.M. 't, Maagdenberg, A.M.J.M. van den, Harst, P. van der, Horst, I.C.C. van der, Kallen, C.J.H. van der, Greevenbroek, M.M.J. van, Spil, W.E. van, Wijmenga, C., Zwinderman, A.H., Zhernikova, A., Jukema, J.W., Mei, H., Slofstra, M., Swertz, M., Akker, E.B. van den, Deelen, J., Reinders, M.J.T., BBMRI Metabolomics Consortium, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Cardiovascular Centre (CVC), Center for Liver, Digestive and Metabolic Diseases (CLDM), Neurology, Epidemiology and Data Science, ACS - Heart failure & arrhythmias, APH - Health Behaviors & Chronic Diseases, General practice, APH - Methodology, Amsterdam Reproduction & Development (AR&D), APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Psychiatry, Laboratory Medicine, Other Research, APH - Aging & Later Life, APH - Personalized Medicine, APH - Digital Health, ACS - Diabetes & metabolism, Adult Psychiatry, Epidemiology, Cardiology, Radiology & Nuclear Medicine, Biological Psychology, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3), Interne Geneeskunde, MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Endocrinologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Hematologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Reumatologie (9), and RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome

Subjects
Netherlands Twin Register (NTR), 0301 basic medicine, SELECTION, Quantitative trait loci, Nutrition and Disease, DATABASE, Metabolite, Science, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], General Physics and Astronomy, Genome-wide association study, VARIANCE-ESTIMATION, Biology, Quantitative trait locus, GENOTYPE IMPUTATION, METABOLOMICS, BIOBANK, Genome-wide association studies, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Metabolomics, All institutes and research themes of the Radboud University Medical Center, Missing heritability problem, MISSING HERITABILITY, Voeding en Ziekte, Genetic variation, Life Science, NETHERLANDS TWIN REGISTER, lcsh:Science, VLAG, Genetics, Multidisciplinary, General Chemistry, Heritability, Genetic architecture, 030104 developmental biology, chemistry, Lipidomics, lcsh:Q, 030217 neurology & neurosurgery
Abstract

Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes. We perform a review of all genome-wide association and (exome-) sequencing studies published between November 2008 and October 2018, and identify >800 class-specific metabolite loci associated with metabolite levels. In a twin-family cohort (N = 5117), these metabolite loci are leveraged to simultaneously estimate total heritability (h2total), and the proportion of heritability captured by known metabolite loci (h2Metabolite-hits) for 309 lipids and 52 organic acids. Our study reveals significant differences in h2Metabolite-hits among different classes of lipids and organic acids. Furthermore, phosphatidylcholines with a high degree of unsaturation have higher h2Metabolite-hits estimates than phosphatidylcholines with low degrees of unsaturation. This study highlights the importance of common genetic variants for metabolite levels, and elucidates the genetic architecture of metabolite classes., Blood metabolite levels are under the influence of environmental and genetic factors. Here, Hagenbeek et al. perform heritability estimations for metabolite measures and determine the contribution of known metabolite loci to metabolite levels using data from 40 genome-wide association studies.

Published
2020

5. Serum fatty acid chain length associates with prevalent symptomatic end-stage osteoarthritis, independent of BMI

Author

Meessen, J.M.T.A., Saberi-Hosnijeh, F., Bomer, N. (Nils), den Hollander, W, Bom, J.G., van Hilten, J.A., Spil, W.E. (Willem) van, So-Osman, C. (Cynthia), Uitterlinden, A.G. (André), Kloppenburg, M. (Margreet), Nelissen, R.G.H.H. (Rob), Duijn, C.M., Slagboom, PE, Meurs, J.B.J. (Joyce) van, Meulenbelt, I. (Ingrid), Meessen, J.M.T.A., Saberi-Hosnijeh, F., Bomer, N. (Nils), den Hollander, W, Bom, J.G., van Hilten, J.A., Spil, W.E. (Willem) van, So-Osman, C. (Cynthia), Uitterlinden, A.G. (André), Kloppenburg, M. (Margreet), Nelissen, R.G.H.H. (Rob), Duijn, C.M., Slagboom, PE, Meurs, J.B.J. (Joyce) van, and Meulenbelt, I. (Ingrid)

Published
2020
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6. Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies (Nature Communications, (2020), 11, 1, (39), 10.1038/s41467-019-13770-6)

Author

Hagenbeek, F.A. (Fiona A.), Pool, R. (Reńe), Dongen, J. (Jenny) van, Draisma, G. (Gerrit), Hottenga, J.J. (Jouke Jan), Willemsen, G. (Gonneke), Abdellaoui, A. (Abdel), Fedko, I.O. (Iryna O.), Braber, A. (Anouk) den, Visser, P. (Pim), Geus, E.J.C. (Eco) de, Willems van Dijk, K. (Ko), Verhoeven, A. (Aswin), Suchiman, H.E. (H. Eka), Beekman, M. (Marian), Slagboom, P.E. (Eline), Duijn, C.M. (Cornelia) van, Barkey Wolf, J.J.H. (J. J.H.), Cats, D. (D.), Amin, N. (N.), Beulens, J.W.J. (Joline), van der Bom, J.A. (J. A.), Bomer, N. (Nils), Demirkan, A. (Ayşe), van Hilten, J.A. (J. A.), Meessen, J.M.T.A. (J. M.T.A.), Moed, H. (Heleen), Fu, J. (J.), Onderwater, G.L.J. (G. L.J.), Rutters, F. (F.), So-Osman, C. (Cynthia), van der Flier, W.M. (W. M.), Heijden, A.A.W.A. (Amber A. W.) van der, Spek, A. (Ashley) van der, Asselbergs, F.W. (F. W.), Boersma, H. (Eric), Elders, P.M. (P. M.), Geleijnse, J.M. (J. M.), Ikram, M.A. (Arfan), Kloppenburg, M. (Margreet), Meulenbelt, I. (I.), Mooijaart, S.P. (Simon), Nelissen, R.G.H.H. (Rob), Netea, M.G. (Mihai), Penninx, B.W.J.H. (Brenda), Stehouwer, C.D.A. (C. D.A.), Teunissen, C.E. (Charlotte), Terwindt, G.M. (G. M.), ‘t Hart, L.M. (L. M.), van den Maagdenberg, A.M.J.M. (A. M.J.M.), Harst, P. (Pim) van der, van der Horst, I.C.C. (I. C.C.), Kallen, C.J. van der, van Greevenbroek, M.M.J. (M. M.J.), Spil, W.E. (Willem) van, Wijmenga, C. (Cisca), Zwinderman, A.H. (Ailko), Zhernikova, A. (A.), Jukema, J.W. (Jan Wouter), Mei, H. (H.), Slofstra, M. (M.), Swertz, M. (M.), Akker, E.B. (Erik) van den, Deelen, J. (Joris), Reinders, M.J.T. (M. J.T.), Harms, A.C. (Amy), Hankemeier, T. (Thomas), Bartels, M. (Meike), Nivard, M. (Michel), Boomsma, D.I. (Dorret), Hagenbeek, F.A. (Fiona A.), Pool, R. (Reńe), Dongen, J. (Jenny) van, Draisma, G. (Gerrit), Hottenga, J.J. (Jouke Jan), Willemsen, G. (Gonneke), Abdellaoui, A. (Abdel), Fedko, I.O. (Iryna O.), Braber, A. (Anouk) den, Visser, P. (Pim), Geus, E.J.C. (Eco) de, Willems van Dijk, K. (Ko), Verhoeven, A. (Aswin), Suchiman, H.E. (H. Eka), Beekman, M. (Marian), Slagboom, P.E. (Eline), Duijn, C.M. (Cornelia) van, Barkey Wolf, J.J.H. (J. J.H.), Cats, D. (D.), Amin, N. (N.), Beulens, J.W.J. (Joline), van der Bom, J.A. (J. A.), Bomer, N. (Nils), Demirkan, A. (Ayşe), van Hilten, J.A. (J. A.), Meessen, J.M.T.A. (J. M.T.A.), Moed, H. (Heleen), Fu, J. (J.), Onderwater, G.L.J. (G. L.J.), Rutters, F. (F.), So-Osman, C. (Cynthia), van der Flier, W.M. (W. M.), Heijden, A.A.W.A. (Amber A. W.) van der, Spek, A. (Ashley) van der, Asselbergs, F.W. (F. W.), Boersma, H. (Eric), Elders, P.M. (P. M.), Geleijnse, J.M. (J. M.), Ikram, M.A. (Arfan), Kloppenburg, M. (Margreet), Meulenbelt, I. (I.), Mooijaart, S.P. (Simon), Nelissen, R.G.H.H. (Rob), Netea, M.G. (Mihai), Penninx, B.W.J.H. (Brenda), Stehouwer, C.D.A. (C. D.A.), Teunissen, C.E. (Charlotte), Terwindt, G.M. (G. M.), ‘t Hart, L.M. (L. M.), van den Maagdenberg, A.M.J.M. (A. M.J.M.), Harst, P. (Pim) van der, van der Horst, I.C.C. (I. C.C.), Kallen, C.J. van der, van Greevenbroek, M.M.J. (M. M.J.), Spil, W.E. (Willem) van, Wijmenga, C. (Cisca), Zwinderman, A.H. (Ailko), Zhernikova, A. (A.), Jukema, J.W. (Jan Wouter), Mei, H. (H.), Slofstra, M. (M.), Swertz, M. (M.), Akker, E.B. (Erik) van den, Deelen, J. (Joris), Reinders, M.J.T. (M. J.T.), Harms, A.C. (Amy), Hankemeier, T. (Thomas), Bartels, M. (Meike), Nivard, M. (Michel), and Boomsma, D.I. (Dorret)

Abstract

The original version of the Supplementary Information associated with this Article included an incorrect Supplementary Data 1 file, in which additional delimiters were included in the first column for a number of rows, resulting in column shifts for some of these rows. The HTML has been updated to include a corrected version of Supplementary Data 1; the original incorrect version of Supplementary Data 1 can be found as Supplementary Information associated with this Correction. In addition, the original version of this Article contained an error in the author affiliations. An affiliation of Abdel Abdellaoui with Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands was inadvertently omitted. This has now been corrected in both the PDF and HTML versions of the Article.

Published
2020
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7. Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

Author

Hagenbeek, F.A. (Fiona A.), Pool, R. (Reńe), Dongen, J. (Jenny) van, Draisma, G. (Gerrit), Hottenga, J.J. (Jouke Jan), Willemsen, G. (Gonneke), Abdellaoui, A. (Abdel), Fedko, I.O. (Iryna O.), Braber, A. (Anouk) den, Visser, P.J. (Pieter Jelle), de Geus, E.J.C.N. (Eco J. C. N.), Willems van Dijk, K. (Ko), Verhoeven, A. (Aswin), Suchiman, H.E. (H. Eka), Beekman, M. (Marian), Slagboom, P.E. (Eline), Duijn, C.M. (Cornelia) van, Barkey Wolf, J.J.H. (J. J.H.), Cats, D. (D.), Amin, N. (N.), Beulens, J.W.J. (Joline), van der Bom, J.A. (J. A.), Bomer, N. (Nils), Demirkan, A. (Ayşe), van Hilten, J.A. (J. A.), Meessen, J.M.T.A. (J. M.T.A.), Moed, H. (Heleen), Fu, J. (J.), Onderwater, G.L.J. (G. L.J.), Rutters, F. (F.), So-Osman, C. (Cynthia), Flier, W.M. (Wiesje) van der, Heijden, A.A.W.A. (Amber A. W.) van der, Spek, A. (Ashley) van der, Asselbergs, F.W. (F. W.), Boersma, H. (Eric), Elders, P.M. (P. M.), Geleijnse, J.M. (Marianne), Ikram, M.A. (Arfan), Kloppenburg, M. (Margreet), Meulenbelt, I. (I.), Mooijaart, S.P. (Simon), Nelissen, R.G.H.H. (Rob), Netea, M.G. (Mihai), Penninx, B.W.J.H. (Brenda), Stehouwer, C.D. (Coen), Teunissen, C.E. (Charlotte), Terwindt, G.M. (Gisela), ‘t Hart, L.M. (L. M.), Maagdenberg, A.M.J.M. (Arn), Harst, P. (Pim) van der, van der Horst, I.C.C. (I. C.C.), Kallen, C.J. van der, van Greevenbroek, M.M.J. (M. M.J.), Spil, W.E. (Willem) van, Wijmenga, C. (C.), Zwinderman, A.H. (A. H.), Zhernikova, A. (A.), Jukema, J.W. (Jan Wouter), Mei, H. (H.), Slofstra, M. (M.), Swertz, M. (M.), Akker, E.B. (Erik) van den, Deelen, J. (Joris), Reinders, M.J.T. (M. J.T.), Harms, A.C. (Amy C.), Hankemeier, T. (Thomas), Bartels, M. (Meike), Nivard, M. (Michel), Boomsma, D.I. (Dorret), Hagenbeek, F.A. (Fiona A.), Pool, R. (Reńe), Dongen, J. (Jenny) van, Draisma, G. (Gerrit), Hottenga, J.J. (Jouke Jan), Willemsen, G. (Gonneke), Abdellaoui, A. (Abdel), Fedko, I.O. (Iryna O.), Braber, A. (Anouk) den, Visser, P.J. (Pieter Jelle), de Geus, E.J.C.N. (Eco J. C. N.), Willems van Dijk, K. (Ko), Verhoeven, A. (Aswin), Suchiman, H.E. (H. Eka), Beekman, M. (Marian), Slagboom, P.E. (Eline), Duijn, C.M. (Cornelia) van, Barkey Wolf, J.J.H. (J. J.H.), Cats, D. (D.), Amin, N. (N.), Beulens, J.W.J. (Joline), van der Bom, J.A. (J. A.), Bomer, N. (Nils), Demirkan, A. (Ayşe), van Hilten, J.A. (J. A.), Meessen, J.M.T.A. (J. M.T.A.), Moed, H. (Heleen), Fu, J. (J.), Onderwater, G.L.J. (G. L.J.), Rutters, F. (F.), So-Osman, C. (Cynthia), Flier, W.M. (Wiesje) van der, Heijden, A.A.W.A. (Amber A. W.) van der, Spek, A. (Ashley) van der, Asselbergs, F.W. (F. W.), Boersma, H. (Eric), Elders, P.M. (P. M.), Geleijnse, J.M. (Marianne), Ikram, M.A. (Arfan), Kloppenburg, M. (Margreet), Meulenbelt, I. (I.), Mooijaart, S.P. (Simon), Nelissen, R.G.H.H. (Rob), Netea, M.G. (Mihai), Penninx, B.W.J.H. (Brenda), Stehouwer, C.D. (Coen), Teunissen, C.E. (Charlotte), Terwindt, G.M. (Gisela), ‘t Hart, L.M. (L. M.), Maagdenberg, A.M.J.M. (Arn), Harst, P. (Pim) van der, van der Horst, I.C.C. (I. C.C.), Kallen, C.J. van der, van Greevenbroek, M.M.J. (M. M.J.), Spil, W.E. (Willem) van, Wijmenga, C. (C.), Zwinderman, A.H. (A. H.), Zhernikova, A. (A.), Jukema, J.W. (Jan Wouter), Mei, H. (H.), Slofstra, M. (M.), Swertz, M. (M.), Akker, E.B. (Erik) van den, Deelen, J. (Joris), Reinders, M.J.T. (M. J.T.), Harms, A.C. (Amy C.), Hankemeier, T. (Thomas), Bartels, M. (Meike), Nivard, M. (Michel), and Boomsma, D.I. (Dorret)

Abstract

Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes. We perform a review of all genome-wide association and (exome-) sequencing studies published between November 2008 and October 2018, and identify >800 class-specific metabolite loci associated with metabolite levels. In a twin-family cohort (N = 5117), these metabolite loci are leveraged to simultaneously estimate total heritability (h2 total), and the proportion of heritability captured by known metabolite loci (h2 Metabolite-hits) for 309 lipids and 5

Published
2020
Full Text
View/download PDF

8. Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

Author

Hagenbeek, Fiona A., Pool, René, van Dongen, Jenny, Draisma, Harmen H.M., Hottenga, Jouke Jan, Willemsen, Gonneke, Abdellaoui, Abdel, Fedko, Iryna O., den Braber, Anouk, Visser, Pieter Jelle, de Geus, Eco J.C.N., Willems van Dijk, Ko, Verhoeven, Aswin, Suchiman, H.E., Beekman, Marian, Slagboom, Eline P., van Duijn, Cornelia M., Barkey Wolf, J.J.H., Cats, D., Amin, N., Beulens, J.W., van der Bom, J.A., Bomer, N., Demirkan, A., van Hilten, J.A., Meessen, J.M.T.A., Moed, M.H., Fu, J., Onderwater, G.L.J., Rutters, F., So-Osman, C., van der Flier, W.M., van der Heijden, A.A.W.A., van der Spek, A., Asselbergs, F.W., Boersma, E., Elders, P.M., Geleijnse, J.M., Ikram, M.A., Kloppenburg, M., Meulenbelt, I., Mooijaart, S.P., Nelissen, R.G.H.H., Netea, M.G., Penninx, B.W.J.H., Stehouwer, C.D.A., Teunissen, C.E., Terwindt, G.M., Jukema, J.W., Reinders, M.J.T., Hagenbeek, Fiona A., Pool, René, van Dongen, Jenny, Draisma, Harmen H.M., Hottenga, Jouke Jan, Willemsen, Gonneke, Abdellaoui, Abdel, Fedko, Iryna O., den Braber, Anouk, Visser, Pieter Jelle, de Geus, Eco J.C.N., Willems van Dijk, Ko, Verhoeven, Aswin, Suchiman, H.E., Beekman, Marian, Slagboom, Eline P., van Duijn, Cornelia M., Barkey Wolf, J.J.H., Cats, D., Amin, N., Beulens, J.W., van der Bom, J.A., Bomer, N., Demirkan, A., van Hilten, J.A., Meessen, J.M.T.A., Moed, M.H., Fu, J., Onderwater, G.L.J., Rutters, F., So-Osman, C., van der Flier, W.M., van der Heijden, A.A.W.A., van der Spek, A., Asselbergs, F.W., Boersma, E., Elders, P.M., Geleijnse, J.M., Ikram, M.A., Kloppenburg, M., Meulenbelt, I., Mooijaart, S.P., Nelissen, R.G.H.H., Netea, M.G., Penninx, B.W.J.H., Stehouwer, C.D.A., Teunissen, C.E., Terwindt, G.M., Jukema, J.W., and Reinders, M.J.T.

Abstract

Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes. We perform a review of all genome-wide association and (exome-) sequencing studies published between November 2008 and October 2018, and identify >800 class-specific metabolite loci associated with metabolite levels. In a twin-family cohort (N = 5117), these metabolite loci are leveraged to simultaneously estimate total heritability (h2 total), and the proportion of heritability captured by known metabolite loci (h2 Metabolite-hits) for 309 lipids and 52 organic acids. Our study reveals significant differences in h2 Metabolite-hits among different classes of lipids and organic acids. Furthermore, phosphatidylcholines with a high degree of unsaturation have higher h2 Metabolite-hits estimates than phosphatidylcholines with low degrees of unsaturation. This study highlights the importance of common genetic variants for metabolite levels, and elucidates the genetic architecture of metabolite classes.

Published
2020

9. Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls

Author

Bot, Mariska, primary, Milaneschi, Yuri, additional, Al-Shehri, Tahani, additional, Amin, Najaf, additional, Garmaeva, Sanzhima, additional, Onderwater, Gerrit L.J., additional, Pool, Rene, additional, Thesing, Carisha S., additional, Vijfhuizen, Lisanne S., additional, Vogelzangs, Nicole, additional, Arts, Ilja C.W., additional, Demirkan, Ayse, additional, van Duijn, Cornelia, additional, van Greevenbroek, Marleen, additional, van der Kallen, Carla J.H., additional, Köhler, Sebastian, additional, Ligthart, Lannie, additional, van den Maagdenberg, Arn M.J.M., additional, Mook-Kanamori, Dennis O., additional, de Mutsert, Renée, additional, Tiemeier, Henning, additional, Schram, Miranda T., additional, Stehouwer, Coen D.A., additional, Terwindt, Gisela M., additional, Willems van Dijk, Ko, additional, Fu, Jingyuan, additional, Zhernakova, Alexandra, additional, Beekman, Marian, additional, Slagboom, P. Eline, additional, Boomsma, Dorret I., additional, Penninx, Brenda W.J.H., additional, Beekman, M., additional, Suchiman, H.E.D., additional, Deelen, J., additional, Amin, N., additional, Beulens, J.W., additional, van der Bom, J.A., additional, Bomer, N., additional, Demirkan, A., additional, van Hilten, J.A., additional, Meessen, J.M.T.A., additional, Pool, R., additional, Moed, M.H., additional, Fu, J., additional, Onderwater, G.L.J., additional, Rutters, F., additional, So-Osman, C., additional, van der Flier, W.M., additional, van der Heijden, A.A.W.A., additional, van der Spek, A., additional, Asselbergs, F.W., additional, Boersma, E., additional, Elders, P.M., additional, Geleijnse, J.M., additional, Ikram, M.A., additional, Kloppenburg, M., additional, Meulenbelt, I., additional, Mooijaart, S.P., additional, Nelissen, R.G.H.H., additional, Netea, M.G., additional, Penninx, B.W.J.H., additional, Stehouwer, C.D.A., additional, Teunissen, C.E., additional, Terwindt, G.M., additional, ’t Hart, L.M., additional, van den Maagdenberg, A.M.J.M., additional, van der Harst, P., additional, van der Horst, I.C.C., additional, van der Kallen, C.J.H., additional, van Greevenbroek, M.M.J., additional, van Spil, W.E., additional, Wijmenga, C., additional, Zwinderman, A.H., additional, Zhernikova, A., additional, Jukema, J.W., additional, and Sattar, N., additional

Published
2020
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10. Outcome of osteoarthritis and arthroplasty from patient perspective to molecular profiling

Author

Meessen, J.M.T.A., Nelissen, R.G.H.H., Slagboom, P.E., Vliet Vlieland, T.P.M., Gussekloo, J., Verhaar, J.A.N., Willems, H.C., and Leiden University

Subjects
osteoarthritis, disability, arthoplasty, patient perspective, metabolomics, Patient reported outcome measures
Abstract

With increasing life expectancy, the incidence and burden of osteoarthritis on society increases. Currently, no treatment for end-stage symptomatic osteoarthritis is available and when symptoms become too severe arthroplasty surgery will be performed, replacing the affected joint with a prosthesis. Although replacement surgery of the hip or knee is safe and commonly performed, up to 20% of the patients are unsatisfied with the outcome. The exact reasons for this dissatisfaction are unknown but may vary from the type of surgical procedure itself, expectancy of the outcome surgery to the patient’s preoperative state of overall metabolic health. We aimed to evaluate some of these aspects related to outcome, from patient perspectives to molecular profiling (e.g. metabolic health). Characteristics of different nature were included: material of prosthesis, physical activity, questionnaires, clinical measures and metabolomics. This holistic approach enables the assessment of more patient specific targets such as advices on treatment modalities. Ultimately, selection of patients, both from a patient’s as well as orthopaedic surgeon’s perspective, will be optimised for the best intervention for the patient. Since osteoarthritis is the major driver for performing arthroplasty, the conclusion of this thesis will spark future studies into OA and its overall effect on disability.

Published
2019

11. Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis

Author

Panoutsopoulou, K., Thiagarajah, S., Zengini, E., Day-Williams, A.G., Ramos, Y.F.M., Meessen, J.M.T.A., Huetink, K., Nelissen, R.G.H.H., Southam, L., Rayner, N.W., Doherty, M., Meulenbelt, I., Zeggini, E., Wilkinson, J.M., and ArcOGEN Consortium

Abstract

OBJECTIVE: Osteoarthritis (OA) has a strong genetic component but the success of previous genome-wide association studies (GWAS) has been restricted due to insufficient sample sizes and phenotype heterogeneity. Our aim was to examine the effect of clinically relevant endophenotyping according to site of maximal joint space narrowing (maxJSN) and bone remodelling response on GWAS signal detection in hip OA. METHODS: A stratified GWAS meta-analysis was conducted in 2118 radiographically defined hip OA cases and 6500 population-based controls. Signals were followed up by analysing differential expression of proximal genes for bone remodelling endophenotypes in 33 pairs of macroscopically intact and OA-affected cartilage. RESULTS: We report suggestive evidence (p0.05). STT3B was significantly upregulated in OA-affected versus intact cartilage, particularly in the analysis of hypertrophic and normotrophic compared with atrophic bone remodelling pattern (p=4.2×10(-4)). CONCLUSIONS: Our findings demonstrate that stratification of OA cases into more homogeneous endophenotypes can identify genes of potential functional importance otherwise obscured by disease heterogeneity.

Published
2017

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