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Your search keyword '"Meerovich, I G"' showing total 29 results
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29 results on '"Meerovich, I G"'

9. Study of level and selectivity of liposomal form of photosensitiser hydroxyaluminium tetra-3-phenylthiophthalocyanine accumulation on transplantable mice tumor models at different ways of transplantation

Author

Meerovich, G. A., primary, Borisova, L. M., additional, Bud’Ko, A. P., additional, Kiseleva, M. P., additional, Nikolaeva, L. L., additional, Meerovich, I. G., additional, Lantsova, A. V., additional, Chernova, S. V., additional, and Oborotova, N. A., additional

Published
2017
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10. Prospects for multimodal imaging of biological tissues using fluorescence imaging

Author

Tuchina, D K, Meerovich, I G, Sindeeva, O A, Zherdeva, V V, Kazachkina, N I, Solov'ev, I D, Savitsky, A P, Bogdanov, A A, and Tuchin, V V

Abstract

We investigate skin optical clearing in laboratory animals ex vivo and in vivo by means of low-molecular-weight paramagnetic contrast agents used in magnetic resonance imaging (MRI) and a radiopaque agent used in computed tomography (CT) to increase the sounding depth and image contrast in the methods of fluorescence laser imaging and optical coherence tomography (OCT). The diffusion coefficients of the MRI agents Gadovist®, Magnevist®, and Dotarem®, which are widely used in medicine, and the Visipaque®CT agent in ex vivo mouse skin, are determined from the collimated transmission spectra. MRI agents Gadovist®and Magnevist®provide the greatest optical clearing (optical transmission) of the skin, which allowed: 1) an almost 19-fold increase in transmission at 540 nm and a 7 - 8-fold increase in transmission in the NIR region from 750 to 900 nm; 2) a noticeable improvement in OCT images of skin architecture; and 3) a 5-fold increase in the ratio of fluorescence intensity to background using TagRFP-red fluorescent marker protein expressed in a tumour, after application to the skin of animals in vivo for 15 min. The obtained results are important for multimodal imaging of tumours, namely, when combining laser fluorescence and OCT methods with MRI and CT, since the contrast agents under study can simultaneously enhance the contrast of several imaging methods.

Published
2021
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16. In vivo evaluation of accumulation of sensitizers for oncological diagnostics and therapy using the method of diffuse reflectance spectroscopy

Author

Meerovich, I. G., primary, Stratonnikov, A. A., additional, Ryabova, A. V., additional, Meerovich, G. A., additional, Oborotova, N. A., additional, Brandis, A., additional, Lukyanets, E. A., additional, Kaliya, O. L., additional, Bendel, P., additional, Loschenov, V. B., additional, Scherz, A., additional, and Baryshnikov, A. Y., additional

Published
2005
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28. [Study of optical absorption of sensitizers in vivo].

Author

Meerovich IG, Stratonnikov AA, Riabova AV, Meerovich GA, Oborotova NA, Smirnova ZS, Kubasova IIu, Brandis A, Luk'ianets EA, Kaliia OL, Bendel' P, Loshchenov VB, Sherts A, Vorozhtsov GN, and Baryshnikov AIu

Subjects
Equipment Design, Fluorescence, Humans, Magnetic Resonance Imaging, Radiation-Sensitizing Agents administration & dosage, Models, Biological, Radiation-Sensitizing Agents pharmacology, Spectrum Analysis instrumentation, Tomography, Optical Coherence methods
Abstract

The subject of the paper is study of optical absorption of sensitizers in biological tissue. The study shows that absorbance can be used as a tool that allows studying biodistribution of sensitizers and their interaction with tissue in vivo. The article presents a simple technique of determining biological tissue absorption in vivo, and discusses the results of experimental animal studies of some sensitizers.

Published
2005

29. [Synthesis of phthalocyanine conjugates with monoclonal antibodies in AOT/n-octane reversed micelles and in water-organic solvent mixtures].

Author

Matveeva EG, Meerovich IG, and Savitskiĭ AP

Subjects
Aluminum chemistry, Ascorbic Acid chemistry, Cobalt chemistry, Dioctyl Sulfosuccinic Acid chemistry, Immunoconjugates isolation & purification, Micelles, Octanes chemistry, Ovalbumin, Oxidation-Reduction, Solvents chemistry, Spectrometry, Fluorescence, Water chemistry, Antibodies, Monoclonal chemistry, Immunoconjugates chemistry, Indoles chemistry, Organometallic Compounds chemistry
Abstract

Conjugates of cobalt and aluminum phthalocyanines with monoclonal antibodies were synthesized using an AOT/n-octane reversed micellar system or water-organic mixtures with a low content of organic solvent as media. The effect of the degree of hydration of the micelles and the concentration of phthalocyanines on the composition of conjugates was studied. The immune activity of the resulting conjugates in comparison to that of native antibodies was evaluated. The catalytic activity of free cobalt phthalocyanines and their antibody conjugates was studied in the reaction of ascorbic acid oxidation.

Published
1998

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