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An aneurysm is an abnormal bulge or ballooning in the wall of a blood vessel and aneurysm ruptures may lead to sudden death. Aneurysms of the extracranial carotid arteries are uncommon vascular lesions and atherosclerosis is considered a common cause. The rupture of a nontraumatic, uninfected carotid aneurysm is an exceedingly rare event, with only a handful of cases documented in the scientific literature. The present case report is that of the sudden death of a person due to the rupture of a previously undiagnosed carotid aneurysm. The case has been presented considering its rarity.

Guillain-Barré syndrome (GBS) is a rare autoimmune, acute fulminant polyradiculoneuropathy. Incidence is between 1- 4 cases per 100,000 per year. It can affect age groups such as both young and old. The distribution depending on age-specificity appears to be bimodal, and has high rates in young adults as well as the elderly. Mostly manifests as rapidly evolving areflexic motor paralysis with a usual ascending type of paralysis. Autonomic involvement is common with usual manifestations of loss of vasomotor control such as BP fluctuations, postural hypotension, and arrhythmias. Deep tendon reflexes are diminished or disappear in the first few days of disease onset. Several cases have been reported with descending type of paralysis, but they were patients of Miller Fischer syndrome variant of GBS. Only 15% of the cases were reported regarding descending type of paralysis in AIDP variant of GBS. Our patient presented with unusual descending paralysis, starting with the upper limbs and progressively involving weakness of the lower limbs. The patient did not have any comorbid illnesses rather than recent gastrointestinal infections. In the progress of the disease, he developed respiratory complications for which he needed ventilator support and with all supportive care and keen monitoring, the patient was weaned off from the ventilator, a tracheostomy done, and improved. Thus presenting a case of Guillain Barre syndrome with an unusual descending type of paralysis and with all other typical symptoms of this condition, who have been treated with high dose IV immunoglobulin, creates awareness in view of diagnosing the disease even with unusual presentation would save the life of the patient, instead presenting the usual case scenario or rare disease case.

COVID-19 was originated in Wuhan, China, in December 2019 and has been declared a pandemic disease by WHO. The number of infected cases continues unabated and so far, no specific drug approved for targeted therapy. Hence, there is a need for drug discovery from traditional medicine. Tiryaq-e-Wabai is a well-documented formulation in Unani medicine for its wide use as prophylaxis during epidemics of cholera, plague and other earlier epidemic diseases. The objective of the current study is to generate in-silico evidence and evaluate the potency of Tiryaq-e-Wabai against SARS-CoV-2 spike (S) glycoprotein and main protease (3CLpro). The structures of all phytocompounds used in this study were retrieved from PubChem database and some were built using Marvin Sketch. The protein structure of the SARS-CoV-2 S glycoprotein and 3CLpro was retrieved from the PDB ID: 6LZG and 7BQY respectively. AutoDock Vina was used to predict top ranking poses with best scores. The results of the molecular docking showed that phytocompounds of Tiryaq-e-Wabai exhibited good docking power with spike glycoprotein and 3CLpro. Among tested compounds Crocin from Zafran and Aloin A from Sibr showed strong binding to spike glycoprotein and 3CLpro respectively. Molecular dynamics simulation confirmed the stability of the S glycoprotein-Crocin and 3CLpro-Aloin A complexes. The Unani formulation Tiryaq-e-Wabai has great potential to inhibit the SARS-CoV-2, which have to be substantiated with further in-vitro and in-vivo studies. Keywords: In-silico study, SARS-CoV-2, Tiryaq-e-Wabai, Unani formulation, Crocin, Aloin A

Most of the chronic kidney diseases will not produce any symptoms till it reaches an advanced stage. In medicolegal autopsies most of the cases are brought with an unknown pathology. This cross sectional study was conducted to assess the gross and histopathological findings of kidney in medicolegal autopsies in the Department of Forensic Medicine and Toxicology of a tertiary care teaching institute in Imphal from 2018 to 2020. Kidney samples from a total of 170 medicolegal cases, comprising of 135 males and 35 females (M:F = 3.8:1), were examined. The prevalence of kidney findings in the present study was 77%. The commonest kidney pathology encountered was tubular necrosis (51.8%) followed by glomerulosclerosis (15.9%). Acute tubular necrosis was found more commonly in deaths due to trauma resulting in shock, haemorrhage and asphyxia. Incidental findings included a case of right solitary kidney and a rare case of right crossed fused renal ectopia. Even though these conditions of the kidneys were not directly responsible for the death of the individuals, they could have contributed to these deaths up to some extent. Keywords: Medicolegal autopsy, Kidney pathology, Histopathological examination.

Standardization of herbal drugs is an essential aspect while considering the quality of the herbal drug, consistency in bioactive content and therapeutic efficacy. The roots

Objectives The current pandemic caused by Severe Acute Respiratory Syndrome Corona-Virus 2 (SARS-CoV-2) has become a global health menace with significant morbidity and mortality besides huge socioeconomic implications. Despite the approval of few vaccines for the prevention of the disease, the discovery of safe and effective countermeasures especially from natural sources is of paramount importance, as the number of cases continues escalating. Arq Ajīb has long been used for various diseases and its ingredients have been reported for antiviral, antimicrobial, antipyretic, anti-inflammatory, antioxidant activities. The present study investigates the inhibitory effect of phytocompound of Arq Ajīb on potential drug targets of SARS-CoV-2. Methods The structures of phytocompounds present in Arq Ajīb were retrieved from PubChem database and some were illustrated using Marvin Sketch. SARS-CoV-2 S glycoprotein (PDB ID: 6LZG) and 3CLpro (PDB ID: 7BQY) were selected as the target protein. Dock Prep module in UCSF Chimera software was used for receptor structure processing. AutoDock Vina was used to calculate the binding affinities between the protein and ligands and to predict most promising compounds with best scores. Results Molecular docking results predicted that the phytocompounds of Arq Ajīb had good binding affinity and interaction with S glycoprotein and 3CLpro. Quercetin and Isorhoifolin from Mentha arvensis were identified as promising candidates with the potential to interact with 3CLpro and spike glycoprotein and inhibit the viral replication and its entry into the host. Conclusions Arq Ajīb may prove valuable for developing novel therapeutic candidate for COVID-19; however, it has to be substantiated further with in-vitro and in-vivo studies.

The authors have requested that this preprint be removed from Research Square.

The current pandemic caused by Severe Acute Respiratory Syndrome Corona-Virus 2 (SARS-CoV-2) has become a global health menace with significant morbidity and mortality besides huge socioeconomic implications. Despite the approval of few vaccines for the prevention of the disease, the discovery of safe and effective countermeasures especially from natural sources is of paramount importance, as the number of cases continues escalating. Arq Ajīb has long been used for various diseases and its ingredients have been reported for antiviral, antimicrobial, antipyretic, anti-inflammatory, antioxidant activities. The present study investigates the inhibitory effect of phytocompound of Arq Ajīb on potential drug targets of SARS-CoV-2.The structures of phytocompounds present in Arq Ajīb were retrieved from PubChem database and some were illustrated using Marvin Sketch. SARS-CoV-2 S glycoprotein (PDB ID: 6LZG) and 3CLMolecular docking results predicted that the phytocompounds of Arq Ajīb had good binding affinity and interaction with S glycoprotein and 3CLArq Ajīb may prove valuable for developing novel therapeutic candidate for COVID-19; however, it has to be substantiated further with

In this paper, we have used Kaiser Bessel window in the family of FIR filter design, for noise removing in ECG wave form, noise occurs due to outer surface of the thermal and electromagnetics field, FPGA is used to design and implement the Kaiser filter, three blocks are arranged in Verilog with wires, output is find out in Modelsim and Xilinx, Digital step value is find out in Xilinx and analog continues value is find out in Modelsim, circuit design done through ISIS proteus, Kaiser is very simple design like hamming, but Kaiser has beta variable for control the filter threshold, it has high efficiently and low power consumption. For sample we have three electrodes for analysis the heart electronics function. Low pass filter utilized for remove the high frequency noise from ECG

The Internet of Things is a revolution in the direction towards the digitalization of our physical world. The Internet of Things (IoT) is a global platform for society that facilitates advanced services by linking physical and virtual things based on current and emerging information and communication technologies. With the exponential growth in the number of Internet users over the last decade, the Internet has become a part of our life, and IoT is the newest evolving digital technology in home automation. Home automation is used to help maintain pleasant living conditions inside the home. In this regard, we will briefly introduce the IoT for home automation and to gain new experience in home appliances control. The control and monitoring of the home appliances involves user interaction in this part the customization is introduced to minimize the effort of the user.

Without autopsies, hospitals bury their mistakes. However, not every hospital death is autopsied. As a result,experts say, diagnostic errors are missed, opportunities to improve medical treatment are lost and health-carestatistics are skewed. In this 10 year retrospective study, hospital death cases which were brought for autopsywere analyzed with respect to year wise incidence, sex and age wise incidence, reasons for hospitalizationand cause of death to ascertain whether the deaths were due to medical negligence or due to natural courseof events of the disease. The findings reveal that 40% of the cases were due to negligence. This substantialloss could have been prevented if timely intervention was done. The study aims to highlight this importantaspect of medical practice.

The COVID-19 pandemic is threatening the worldwide population. A huge population of world is suffering from this disease and no specific vaccine for this pandemic disease has been developed.The main symptoms of this disease are fever, cough,shortness of breathand tirednessetc. The Ministry of AYUSH has issued various guidelines to prevent this disease by taking immunity boosters and prophylaxis as defence against any disease. In Unani system of medicines, many drugs of plant origin are mentioned in classical literature for strengthening and increasing the immunity of humans. Since, the drug Behidana is being given to COVID-19 patients as prophylaxis regime, it has become necessary to authenticate and develop its pharmacopoeial standards so that quality raw material can be provided to needy mass. The present study is aimed to develop identity, purity and strength of drug using pharmacognostical, physico-chemical and quality control methods. &nbsp

Fatal road traffic accident cases with skull fractures were studied for three years from July 2015 to June 2018 from the medicolegal autopsy cases coming to the Mortuary of the Regional Institute of Medical Sciences, Imphal. The patterns of skull fractures in various types of victims involved in accidents with different types of vehicles were analyzed in detail. It was observed that skull fractures were encountered most commonly in pedestrian victims.Of the various types of skull fractures, comminuted fracture was observed in maximum number of cases (31.5%). Preventive and interventional measures in the form of wearing helmets by two wheeler riders ,strict implementation of traffic rules and prompt emergency services especially neurosurgery facilities which can help in reducing the incidence of road traffic accident fatalities are suggested.

Hydroponics is a technology that can contribute to fulfilling demand for vegetables year-round even where normal agricultural practices cannot be undertaken. However, it is still in its nascent sta...

Objective: Detection and classification of abnormalities in Magnetic Resonance (MR) brain images in medical field is very much needed. The proposed brain tumor classification system composed of denoising, feature extraction and classification. Noise is one of the major problems in the medical image and due to that retrieval of useful information from the image is difficult. The proposed method for denoising an image is PURE-LET transform. Methods: This method preserves the diagnostic property of the images. In feature extraction, combination of Modified Multi-Texton Histogram (MMTH) and Multi-Texton Microstructure Descriptor (MTMD) is used and then Gray Level Co-occurrence Matrix (GLCM) and Gray Level Run Length Matrix (GLRLM)are used to extract the feature from the image to compare performance. In classification, classifiers like Support Vector Machine (SVM), K Nearest Neighbors (KNN) and Extreme Learning Machine (ELM)are trained by the extracted features and are used to classify the images. Result: The performance of feature extraction methods with three different classifiers are compared in terms of the performance metrics like sensitivity, specificity, and accuracy. Conclusion: The result shows that the combination of MMTH and MTMD with SVM shows the highest accuracy of 95%.