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1. Association of dynamic contrast-enhanced MRI and 18F-Fluorodeoxyglucose PET/CT parameters with neoadjuvant therapy response and survival in esophagogastric cancer

Author

Withey, Samuel J., primary, Owczarczyk, Kasia, additional, Grzeda, Mariusz T., additional, Yip, Connie, additional, Deere, Harriet, additional, Green, Mike, additional, Maisey, Nick, additional, Davies, Andrew R., additional, Cook, Gary J., additional, Goh, Vicky, additional, Baker, C.R., additional, Bell, J., additional, Chang, F., additional, Chicklore, S., additional, Cominos, M., additional, Coombes, A., additional, Dunn, J.N., additional, George, S., additional, Gill-Barman, B., additional, Gossage, J.A., additional, Gourtsoyianni, S., additional, Green, A., additional, Griffin, N., additional, Hill, M., additional, Hynes, O., additional, Iezzi, C., additional, Jacques, A., additional, Kelly, M., additional, Mahadeva, U., additional, McEwan, R., additional, Meenan, J., additional, Neji, R., additional, Ngan, S., additional, Padormo, F., additional, Qureshi, A., additional, Reyhani, A., additional, Sharkey, A.R., additional, Spence, J., additional, Subesinghe, M., additional, Tham, G., additional, Waters, J., additional, and Zeki, S.S., additional

Published
2023
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5. Royal academy of medicine in Ireland section of bioengineering: Proceedings of meeting held in dundalk, co. louth, in february 1998.

Author

McAlinden, M. G., Magowan, J., Wilson, D. J., Insley, G., Ferris, P., Prendergast, P. J., Rice, J., Blayney, A. W., Dalstra, M., Walsh, M., McGloughlin, T., Grace, P., Colgan, D., Bray, D., McCormack, B. A. O., Reilly, R., Tancred, D., Carr, A. J., McCormack, B. A. O., Leyland, N. S., Meenan, J., Boyd, A., Akay, M., O’Dwyer, B., McCormack, B. A. O., Dunne, N. J., Ryan, K., Orr, J. F., Stungo, B., Brennan, E. G., O’Hare, N. J., Walsh, M. J., Jordan, M. F., Rasheed, A. M., Kelly, C., Kay, E., Bouchier-Hayes, D. J., Leahy, A., Maher, S. A., O’Reilly, D., Foley, J., Gillan, M. A., Cole, J. S., Raghunathan, S., O’Reilly, M. J. G., Kenny, T., Foley, J., Hourigan, T. F., Lyons, G. M., Cox, S. L., Kernohan, W. G., Fitzpatrick, C., Kernohan, W. G., Dempsey, G. J., Millar, I., Kelly, S., Charlwood, A. P., O’Brien, S., Beverland, D. E., Kavanagh, A., McGloughlin, T., Neligan, M. F., McKenna, J., Laracy, P., Moran, D., O’Beirne, J., Charlwood, A. P., Kelly, S., Nixon, J. R., Beverland, D. E., Kenny, P., Maher, S. A., Murphy, L. A., Prendergast, P. J., O’Rourke, S. K., O’Donoghue, D., Gilchrist, M. D., Caulfield, B., O’Brien, B., Simms, C., Lyons, C. G., Brady, C. L., Badran, S., Clifford, P. M., Burden, D. J., Orr, J. F., Taylor, D., Hill, R., Griffin, S., De Barra, E., Brook, I., Reytil, P., Blades, M., O’Reilly, J. P., Masterson, B. F., Macauley, D., Toner, M., Walker, J., Gillan, J., Boyd, A., Meenan, J., Akay, M., Leyland, N. S., Murphy, H., McNamara, P., Jones, E., Kelly, P., Rajah, L., Dhaif, B., Colville, J., Waide, D. V., Waide, D. V., Lawlor, G., McCormack, A., Carr, A. J., McCartney, W., McNamara, B. P., Connolly, P., Devitt, A., McElwaine, J., O’Reilly, P., Maher, S. A., Eames, M. H. A., Cosgrove, A. P., Baker, R. J., Condron, J., Coyle, E., Nugent, D., Webb, J., Black, N. D., Mclntyre, M., Lowery, M., O’Malley, M., Vaughan, L., Sweeney, P. C., Lyons, G. M., McGiven, R., Collins, A. D., Gibson, M. J., Lyons, G. M., Clernon, G. F., Wilcox, D. J., Shanahan, A., Buckley, P. J., Hanna, S., McGrellis, N., Orr, J. F., Fennel, B., Hill, R., Akinmade, A., Mitchell, A., Pintado, M. R., Douglas, W. H., Ryan, E. E., Savage, E. J., Orr, J. F., Mitchell, E., Silbermann, M., Mullett, H., Ranjith, P., Burke, T., Hill, R., Dorreil, P., Watters, E. P., Spedding, P. L., Grimshaw, J., M Bowler, D. J., Felle, P., Allen, D., McCormack, B. A. O., Moran, R., Lennon, A. B., McCormack, B. A. O., Prendergast, P. J., Thompson, N. S., Cosgrove, A. P., Baker, R. J., Saunders, J. L., Taylor, T., Grimson, J., Grimson, W., Azuaje, F., Black, N. D., Adamson, K., Lopes, P., Dubitzky, W., Wu, X., White, J., Murtagh, F., Campbell, J. G., Adamson, K., O’Tiarnaigh, R. I., Cormack, W. A., Hume, A., Starck, J. L., Lardillier, P., Kernohan, W. G., Mao, W. E., Bell, D., Chambers, M. G. A., McCammon, C., Leane, G. E., Lyons, G. M., Lyons, D. J., Lacrox, D., Murphy, L. A., Prendergast, P. J., FitzPatrick, D. P., McClorey, M., Meenen, J., O’Brien, F. J., Lee, T. C., Pellegrini, F., Dickson, G. R., and Taylor, D.

Published
1998
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10. Epidemiology

Author

Fixa, B., Komárková, O., Krejsek, K., Bures, J., Nozicka, Z., Giorcelli, W., Rodi, M., Camisasca, G., Martinotti, R. G., Mendall, M. A., Goggin, P. M., Molineaux, Nicola, Levy, Joanne, Toosy, T., Strachan, D., Northfield, T. C., Vorobjova, T., Vassiljev, V., Kisand, K., Wadström, T., Uibo, R., Zotz, R. B., Xu, S. G., Recklinghausen, G. von, Meusers, P., Goebell, H., Rhee, K. H, Youn, H. S., Paik, S. K., Lee, W. K., Cho, M. J., Park, C. K., Li, Yuyuan, Hu, Pinjin, Du, Guoguang, Wong, Zhijin, Hazell, Stuart L., Mitchell, Hazel M., Korwin, J. D. de, Remot, P., Hartemann, Ph, Catelle, A., Conroy, M. C., Schmitt, J., Stolte, M., Wellens, E., Bethke, B., Ritter, M., Eidt, H., Zanten, S. Veldhuyzen van, Best, L., Bezanson, G., Marrie, T., Poniewierka, E., Gosciniak, G., Matysiak-Budnik, T., Quatrini, M., Boni, F., Baldassarri, A. R., Vecchi, A. De, Castelnovo, C., Viganò, E., Tenconi, L., Bianchi, P. A., Carlucci, A., Ferrini, G., Bianco, I, Larcinese, G., Sciascio, A. Di, Fly, G. F., Hauge, T., Persson, J., Coelho, L. G. V., Teixeira, M. M., Passos, M. C. F., Givisiez, C. B., Santos, C. M. F. R., Rodrigues, C. J. S., Chausson, Y., Castro, L. P., Hyvärinen, Hannu, Seppälä, Kari, Kivilaakso, Eero, Kosunen, Timo, Gormse, Martin, Pilotto, A., Vianello, F., Tornaboni, D., Dotto, P., Battaglia, G., Binda, F., Mario, F. Di, Donisi, P. M., Pasini, M., Benve-nuti, M. E., Stracca-Pansa, V., Pasquino, M., Jablonowski, H., Szelényi, H., Hengels, K. J., Strohmeyer, G., Banatvala, N., Mayo, K., Megraud, F., Jennings, R., Deeks, J. J., Feldman, R. A., Bulighin, G., Ederie, A., Pilati, S., Franzin, G., Zamboni, G., Maran, M., Musola, R., Tobin, A., Hackman, R. C., McDonald, G. B., Fatela, N., Cristino, J. Melo, Monteiro, L., Ramalho, F., Saragoça, A., Salgado, M. J., Moura, M. Cameiro de, Pretolani, S., Gasbarrini, G., Bonvicini, F., Baraldini, M., Tonelli, E., Gatto, M. R. A., Ghironzi, G. C., égraud, F. M, Bouchard, S., Lubcvzumiska-Kowalska, W., Knapik, Z., Meenan, J., Goggins, M., Shahi, C., Keeling, P. W. N., Keane, C., Weir, D. G., Vaira, D., Miglioli, M., Mulè, P., Holten, J., Menegati, M., Biasco, G., Vergura, M., Nannetti, A., Barbara, L., Boschini, A., Begnini, M., Menegatti, M., Ghira, C., D’Errico, A., Evans, D. G., Asnicar, M. A., Evans, D. J., Graham, D. Y., Lee, C. H., Coschieri, M., Fosse, T., Paul, M. C. St., Michiels, J. R., Delmont, J. P., Péroux, J. L., Pradier, C., Rampai, P., Pazzi, P., Merighi, A., Gamberini, S., Scarliarini, R., Bicochi, R., Libanore, M., Bisi, G., and Gulllini, S.

Published
1992
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11. Irish society of gastroenterology: Proceedings Of Meeting Held

Author

Cotter, L. A., Healy, M., Buckley, M., O’Morain, C., Keane, C., O’Moore, R. R., Dickey, W., Roberts, G., Orr, G., Porter, K., McCrory, D., Halliday, M. I., Hoper, M., Crockard, A., Rowlands, B. J., Chua, A., Dinan, T., Dunbar, B., Weir, D. G., Keeling, P. W. N., Johnston, B. T., Collins, J. S. A., McFarland, R. J., Love, A. H. G., Darzi, A., Speakman, C. T. N., Spigelman, A., Henry, M. M., fnTanner, W. A., fnMcEntee, G. P., fnKeane, F. B., Tighe, O., Bennett, M., Mulcahy, H., Williams, N. N., Duignan, J. P., Bouchier-Hayes, D., O’Donoghue, D., Croke, D. T., Hill, A. D., Walsh, T. N., Hennessy, T. P. J., Goggin, M., Joyce, W. P., Prendergast, C., Gibney, E., Traynor, O. J., Hyland, J., O’Brien, S., Fitzgerald, M. X., Hegarty, J. E., Leahy, A., Grace, P., Qureshi, A., Leader, M., Broe, P., Eustace, S., Blake, N., McDevitt, J., Feighery, C. F., O’Farrelly, C., Kelleher, D., O’Connell, M. A., Stokes, M. A., Hill, G. L., Gaffney, P., O’Leary, J., Doyle, C., Hogan, J., Gaffney, Anne, Attwood, S. E. A., Murphy, P., Stephens, R. B., Wilson, R. H., Gilliland, R., Kee, F., Sloan, J. M., Moorehead, R. J., ’Suilleabhain, G., Horgan, A., Kirwan, W. O., Deans, G. T., Heatley, M., Williamson, K., Parks, T. G., Rowland, B. J., Spence, R. A. J., Mealy, K., Burke, P., Herlyn, M., Redmond, H. P., Clery, A. P., Deasy, J. M., Austin, O., Meenan, J., Canili, R. J., Mathias, P. M., Beattie, S., Hamilton, H., Geoghegan, J. G., Cheng, C. A., Lawson, D. C., Pappas, T. N., Collins, R., Beatie, S., Collins, J. K., O’Sullivan, G., Corbett, A., Clements, W. D. B., MacMathuna, P., Lombard, M., Gimson, A., Westaby, D., Williams, R., Duggan, M., Lennon, J., Crowe, J., Ritchie, A. J., Johnston, F., McGuigan, J., Gibbons, J. R. P., Buchanan, K. D., Gilvarry, J. M., Robinson, R., Fielding, J. F., Lawler, M., Humphries, P., Sheils, O., O’Briain, D. S., McCarthy, J., McDermott, M., Hourihane, D., Gallagher, H., Barry, M., Lennon, F., Hederman, W. P., O’Connell, P. R., Gorey, T. F., Fitzpatrick, J. M., Daly, J. M., Carthy, J. E., Redmond, H., Croake, D., Grace, P. A., Campbell, G., Maguire, O., Lynch, S., Atwood, J., Madrigal, L., Attwood, J., Murphy, A., Shovlin, P., Hegarty, J., Egleston, V., Mealy, K., MacErlean, D. P., Johnston, S., O’Malley, K., McEntee, G., Smyth, E., Moran, B., Plant, G., Rees, M., Brindley, N., Osborne, H., Lane, B., Lynch, G., Geraghty, J., Murphy, D., O’Brien, M., and Harte, P.

Published
1992
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12. Irish Society of Gastroenterology: Proceedings of meeting held in Dublin, 7th & 8th June, 1991

Author

Campbell, W. J., Parks, T. G., Spence, R. A. J., Nevin, N. C., Jazrawi, S., Walsh, T. N., Byrne, P. J., Li, H., Hennessy, T. P. J., Hill, A. D. K., Bolger, C., Prendiville, E. J., Corbett, A., O’Sullivan, G., Collins, J. K., O’Sullivan, M., Nolan, S., O’Donoghue, M., O’Donoghue, Brenda, McCabe, D., O’Brien, S., Dowsett, J., Fitzgerald, M. X., Hegarty, J. E., Madrigal, L., Lynch, S., Kelleher, D., Feighery, C., Weir, D. G., O’Farrelly, C., Feighery, C., Weir, D. G., O’Farrelly, C., Meenan, J., Mulcahy, F., Keeling, P. W. N., Mulcahy, H., Patchett, S., Afdhal, N., O’Donoghue, D. P., Toner, M., Daly, I. L., McCarthy, C., Collins, R., Beattie, S., Keane, C., O’Morain, C., McEniff, N., Hamilton, S., O’Donnell, M. D., Nolan, N. P., Foster-Smith, E., McGeeney, K. F., Burke, G., Joyce, W. P., Delaney, P. V., Choo, K. F., Stevens, F. M., Maher, M., Waldron, R., Caldwell, M. T. P., Murchan, P., Beesley, W., Feeley, T. M., Tanner, W. A., Keane, F. V. B., Stokes, M. A., Hill, G. L., O’Connor, H. J., Redmond, P. L., Dickey, W., Watson, R. G. P., Porter, K. G., Xia, H. X., Daw, M. A., Keane, C. T., O’Morain, C. A., Gardiner, K. R., Abderson, N. H., McCaigue, M. D., Erwin, P. J., Halliday, M. I., Rowlands, B. J., Attwood, S. E. A., Mealy, K., McGrath, J., Abbasakoor, F., Stephens, R. B., Nicholson, P., Mealy, K., Hyland, J., Traynor, O., Grosjean, I., O’Brien, F., Irwin, S. T., Barry, M., Mealy, K., Hyland, J., Traynor, O. J., Tan, K. C., Guiney, E. J., O’Grady, J., Williams, R., Attwood, S. E. A., McGrath, J. P., Stephens, R. B., Byrne, J., Timon, D., Armstrong, C., and Quill, D. S.

Published
1991
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14. Performance of first trimester maternal screening biomarkers pregnancy-associated plasma protein a (PAPP-A) and free beta human chorionic gonadotropin (FBHCG) on the Atellica® IM Analyzer

Author

Williams, L., primary, Poynton, S., additional, Graham, L., additional, Wilkie, M., additional, Williamson, E., additional, Smith, L., additional, Rybacka, A., additional, Smith, N., additional, Zhang, X., additional, Meenan, J., additional, Lei, J., additional, and Clouet, J.C., additional

Published
2019
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25. Lymph node regression and survival following neoadjuvant chemotherapy in oesophageal adenocarcinoma

Author

Davies, A R, primary, Myoteri, D, additional, Zylstra, J, additional, Baker, C R, additional, Wulaningsih, W, additional, Van Hemelrijck, M, additional, Maisey, N, additional, Allum, W H, additional, Smyth, E, additional, Gossage, J A, additional, Lagergren, J, additional, Cunningham, D, additional, Green, M, additional, Kelly, M, additional, Ngan, S, additional, Qureshi, A, additional, Gaya, A, additional, Griffin, N, additional, Jacques, A, additional, Goh, V, additional, Deere, H, additional, Chang, F, additional, Mahadeva, U, additional, Gill-Barman, B, additional, George, S, additional, Dunn, J, additional, Zeki, S, additional, Meenan, J, additional, Hynes, O, additional, Tham, G, additional, Iezzi, C, additional, Dellaportas, D, additional, Cowie, A, additional, Knight, W, additional, and Valeri, N, additional

Published
2018
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35. Oesophageal cancer staging by the nurse endosonographer

Author

Doig, L., Vu, C.K.F., Anderson, S., and Meenan, J.

Subjects
Practice, Care and treatment, Research, Nurses -- Practice -- Research, Esophageal cancer -- Care and treatment -- Research
Abstract

Background: Opportunities to acquire the breadth of training acquired to meet the demands of diagnostic (oesophageal cancer) and interventional (lung cancer, pancreatic cystic lesions) EUS are few and hinder the [...]

Published
2004

38. Mediators of mucosal inflammation: Implications for therapy

Author

VanDullemen, H, Meenan, J, Stronkhorst, A, Tytgat, GNJ, VanDenenter, SJH, University of Groningen, and Center for Liver, Digestive and Metabolic Diseases (CLDM)

Subjects
therapy, INTERLEUKIN-1 RECEPTOR ANTAGONIST, ACTIVE ULCERATIVE-COLITIS, NEUTROPHIL DE-GRANULATION, inflammatory bowel disease, GROWTH-FACTOR-BETA, cytokines inflammatory mediators, GROUP-II PHOSPHOLIPASE-A2, BOWEL-DISEASE, EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS, CROHNS-DISEASE, PLATELET-ACTIVATING-FACTOR, TUMOR-NECROSIS-FACTOR
Abstract

Treatment of inflammatory bowel disease remains a challenge. The major shortcoming in the development of new therapeutic approaches is the fact that the cause of inflammatory bowel disease is still unknown. Recognition of the importance of the arachidonic acid cascade of inflammatory mediators presents the opportunity to specifically inhibit or antagonize leukotriene B4, thromboxane, platelet activating factor, or phospholipase. Interleukins and cytokines have more recently been defined as targets for specific therapy. The results of these specific immune modulating studies are not only important from a therapeutic point of view, but substantially contribute to our understanding of the pathogenic cascades in IBD. In this review, several targets for novel therapeutic intervention are discussed.

Published
1997

39. Preferential expression of the mucosal homing receptor integrin alpha 4 beta 7 in gastrointestinal non-Hodgkin's lymphomas

Author

Drillenburg, P., van der Voort, R., Koopman, G., Dragosics, B., van Krieken, J. H., Kluin, P., Meenan, J., Lazarovits, A. I., Radaszkiewicz, T., Pals, S. T., and Other departments

Subjects
immune system diseases, hemic and lymphatic diseases
Abstract

Recent studies have identified the integrin alpha 4 beta 7 as a mucosal homing receptor that mediates lymphocyte migration to the intestinal mucosa by binding to MAdCAM-1, a vascular recognition molecule (addressin) selectively expressed on mucosal endothelium. In the present study, we have assessed the expression of alpha 4 beta 7 on B- and T-cell non-Hodgkin's lymphomas of different primary localization and on related normal lymphocytes. Among B-lineage lymphomas, expression of alpha 4 beta 7 was present in the majority of cases of malignant lymphomatous polyposis of the intestine and low-grade lymphoma of the mucosa-associated lymphoid tissue/monocytoid B-cell lymphoma and in some cases of precursor B-cell lymphoma. CLL/small lymphocytic lymphoma, (nodal) mantle cell lymphoma, follicular center cell lymphoma, Burkitt's lymphoma, and diffuse large B-cell lymphoma were virtually always alpha 4 beta 7 negative, as was the case when localized in the mucosa-associated lymphoid tissue. The normal B cells of the follicle mantles and part of the B cells of the extrafollicular B-cell compartment of lymphoid tissues expressed moderate levels of alpha 4 beta 7. By contrast, follicular center cells were alpha 4 beta 7 negative. Among T-lineage lymphomas, expression of alpha 4 beta 7 was also strongly related to the primary localization; in mucosal, nodal, and cutaneous T cell lymphomas the percentage of positive cases was 56%, 17%, and 0%, respectively. All cases of precursor T-cell lymphoma were alpha 4 beta 7 negative. High expression of alpha 4 beta 7 was found on a subset of peripheral blood memory T cells as well as on lymphocytes in the intestinal mucosa. We conclude that non-Hodgkin's lymphomas that are related to mucosa-associated B- and T-lymphocyte populations selectively express the mucosal homing receptor alpha 4 beta 7. The presence of this receptor underscores their distinctive character and may play an important role in determining their characteristic mucosal dissemination pattern

Published
1997

40. Attenuation of the inflammatory response in an animal colitis model by neutrophil inhibitory factor, a novel beta 2-integrin antagonist

Author

Meenan, J., Hommes, D. W., Mevissen, M., Dijkhuizen, S., Soule, H., Moyle, M., Büller, H. R., ten Kate, F. W., Tytgat, G. N., van Deventer, S. J., and Other departments

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

Neutrophils are significant effector cells in acute inflammatory bowel disease. Recruitment of these cells is dependent on beta 2-integrin-mediated adhesion and transmigration. The efficacy of neutrophil inhibitory factor (NIF), an antagonist of the beta 2-integrin CD11b/CD18, in ameliorating inflammation was tested in an animal model of acute colitis. Immune-complex colitis was induced in groups of rabbits by using various formalin concentrations (2%, 0.75%, and 0.5%). Animals were treated with rNIF, 10 mg/kg. After they had been killed the mucosal appearance was scored, and tissue saved for histology and quantitation of myeloperoxidase (MPO), leukotriene B4 (LTB4), prostaglandin E2 (PGE2), and thromboxane B2 (TXB2). In the 2% formalin group therapy with rNIF resulted in lower LTB4 (p

Published
1996

41. Metastatic Lymph Node Impostor in Pancreatic Cystadenocarcinoma

Author

Vu CKF, Chang F, Doig L, Meenan J, Vu CKF, Chang F, Doig L, and Meenan J

Abstract

CONTEXT: Lymph node involvement in pancreatic cancer is a predictor of poor patient long-term survival. The detection of multiple metastatic peri-pancreatic nodes by EUS-FNA may dissuade the surgeon from undertaking a curative pancreatic resection. CASE REPORT: We report an interesting case of a man with chronic lymphocytic leukemia, who presented with the diagnostic problem of a pancreatic solid-cystic lesion and multiple malignant-looking peri-pancreatic lymphadenopathy on EUS. EUS-FNA yielded chronic lymphocytic leukaemia involvement in the peri-pancreatic lymph nodes and a markedly elevated CEA in the cystic fluid. The absence of adenocarcinoma involvement of the lymph nodes prompted surgery on the pancreatic lesion with a curative intent. Pancreatic mucinous cystadenocarcinoma was diagnosed and a sub-total pancreatectomy was performed with clear resection margins. All 30 resected peri-pancreatic lymph nodes showed chronic lymphocytic leukemia involvement only. CONCLUSIONS: This case illustrates that abnormal lymphadenopathy adjacent to a primary pancreatic lesion may not necessarily be due to the latter. Systemic lymphoproliferative disease, as in this case, can masquerade as metastatic adenocarcinoma lymph nodes on EUS. EUS-FNA is useful in diagnosing lymphoproliferative disease.

Published
2005

45. Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease

Author

Ansari, A, Hassan, Cesare, Duley, J, Marinaki, A, Shobowale Bakre, E, Seed, P, Meenan, J, Yim, A, Sanderson, J., Ansari, A, Hassan, Cesare, Duley, J, Marinaki, A, Shobowale Bakre, E, Seed, P, Meenan, J, Yim, A, and Sanderson, J.

Abstract

Azathioprine therapy is discontinued in one-third of patients with inflammatory bowel disease because of toxicity or a lack of clinical response. Patients with thiopurine methyltransferase (TPMT) deficiency are intolerant to azathioprine, whilst carriers are at increased risk of side-effects.

Published
2002

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