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Image degradation generally occurs due to transmission channel error, camera misfocus, atmospheric turbulence, relative object-camera motion, etc. Such degradations are unavoidable while a scene is captured through a camera. As degraded images are having less scientific values, restoration of such images is extremely essential in many practical applications. Visual information transmitted in the form of digital images is becoming a major method of communication in the modern age, but the image obtained after transmission is often corrupted with noise. The received image needs processing before it can be used in applications. Image denoising involves the manipulation of the image data to produce a visually high quality image. Salt & pepper (Impulse) noise and the additive white Gaussian noise and blurredness are the types of noise that occur during transmission and capturing. To remove these types of noise we have many filters like mean filter, median filter, inverse filter, wiener filter. No single filter can remove both type of noise. In this paper, attempts have been made to recover images from their degraded observations. Various degradations including, Gaussian noise and salt-n-pepper has been considered, and to recover the image hybrid filter approach has been proposed.

Context: GLP-1 receptor agonists (GLP-1 RA) are unique antidiabetic agents that have the ability to lower blood glucose without causing hypoglycemia, while at the same time promoting weight loss. Information on the efficacy and safety of GLP-1 RA in the Indian diabetic population is limited. Aims: (1) To evaluate the effect of GLP-1 RA, Liraglutide on glycemic control, and weight in obese Indian patients with type 2 diabetes. (2) To study the adverse event profile of Liraglutide in these patients in real-world clinical setting. Settings and Design: Observational study conducted in a tertiary care hospital. Materials and Methods: Liraglutide was prescribed to 196 obese patients with type 2 diabetes who had poor glycemic control on oral medications ± insulin. The initial dose of Liraglutide was 0.6 mg, which was up-titrated to 1.2 mg after 1 week; further up-titration to 1.8 mg was done based on tolerance. Dipeptidyl peptidase-IV (DPP-IV) inhibitors were discontinued and dose of other medications adjusted according to clinical judgment during the study period. Results: Mean age of patients was 49.9 ± 9.6 years. Three month data were available for 175 patients out of a total of 196. At 3 months, glycosylated hemoglobin (HbA1c) was 7.6 ± 0.9% vs. 9.2 ± 1.9% at baseline (P = 0.007) and mean body weight was 96.0 ± 16.5 kg vs. 100.1 ± 17.5 kg at baseline (P < 0.001). Most common adverse events were nausea, burping, and eructation (10%). Conclusion: Liraglutide significantly improves glycemic control with low risk of hypoglycemia and is associated with significant weight loss in obese Indian patients with type 2 diabetes mellitus.