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2. Sulfonamido carboranes as highly selective inhibitors of cancer-specific carbonic anhydrase IX

Author

Dvořanová, Jana, Kugler, Michael, Holub, Josef, Šícha, Václav, Das, Viswanath, Nekvinda, Jan, El Anwar, Suzan, Havránek, Miroslav, Pospíšilová, Klára, Fábry, Milan, Král, Vlastimil, Medvedíková, Martina, Matějková, Stanislava, Lišková, Barbora, Gurská, Soňa, Džubák, Petr, Brynda, Jiří, Hajdúch, Marián, Grüner, Bohumír, and Řezáčová, Pavlína

Published
2020
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5. Laboratory Techniques in Cellular and Molecular Medicine

Author

), Josef Srovnal Ed., additional, Janošťáková, Anna, additional, Das, Viswanath, additional, Kudlová, Natálie, additional, Stránská, Jana, additional, Buriánová, Renata, additional, Kotulová, Jana, additional, Schadich, Ermin, additional, Ondra, Martin, additional, Kubíčková, Agáta, additional, Gurská, Soňa, additional, Flodrová, Pavla, additional, Flodr, Patrik, additional, Kurfürstová, Daniela, additional, Kořínková, Gabriela, additional, Gachechiladze, Mariam, additional, Buchtová, Tereza, additional, Mistrík, Martin, additional, Trojanec, Radek, additional, Šporiková, Zuzana, additional, Řehulka, Jiří, additional, Ligasová, Anna, additional, Koberna, Karel, additional, Stanková, Jarmila, additional, Frydrych, Ivo, additional, Agrawal, Khushboo, additional, Lacey, Matthew, additional, Škrott, Zdeněk, additional, Mašek, Vlastimil, additional, Medvedíková, Martina, additional, Gurský, Ján, additional, Džubák, Petr, additional, De Sanctis, Juan B., additional, Hrubá, Lenka, additional, Václavková, Jana, additional, Holub, Dušan, additional, Oždian, Tomáš, additional, Jakoubková, Martina, additional, Petřík, Miloš, additional, Nový, Zbyněk, additional, Annadurai, Narendran, additional, Carazo, Alejandro, additional, Lišková, Barbora, additional, Koudeláková, Vladimíra, additional, Uniyal, Vaishali, additional, Drábek, Jiří, additional, Macečková, Zuzana, additional, Slavík, Hanuš, additional, Srovnal, Josef, additional, Řehulková, Alona, additional, Bartáková, Karolína, additional, and Slavkovský, Rastislav, additional

Published
2022
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6. Cytoprotective activities of kinetin purine isosteres

Author

Maková, Barbara, primary, Mik, Václav, additional, Lišková, Barbora, additional, Gonzalez, Gabriel, additional, Vítek, Dominik, additional, Medvedíková, Martina, additional, Monfort, Beata, additional, Ručilová, Veronika, additional, Kadlecová, Alena, additional, Khirsariya, Prashant, additional, Gándara Barreiro, Zoila, additional, Havlíček, Libor, additional, Zatloukal, Marek, additional, Soural, Miroslav, additional, Paruch, Kamil, additional, D'Autréaux, Benoit, additional, Hajdúch, Marián, additional, Strnad, Miroslav, additional, and Voller, Jiří, additional

Published
2021
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7. Iodinated Choline Transport-Targeted Tracers

Author

Švec, Pavel, primary, Nový, Zbyněk, additional, Kučka, Jan, additional, Petřík, Miloš, additional, Sedláček, Ondřej, additional, Kuchař, Martin, additional, Lišková, Barbora, additional, Medvedíková, Martina, additional, Kolouchová, Kristýna, additional, Groborz, Ondřej, additional, Loukotová, Lenka, additional, Konefał, Rafał Ł., additional, Hajdúch, Marián, additional, and Hrubý, Martin, additional

Published
2020
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8. Synthesis and Cytotoxic and Antiviral Activity Profiling of All‐Four Isomeric Series of Pyrido‐Fused 7‐Deazapurine Ribonucleosides

Author

Veselovská, Lucia, primary, Kudlová, Natálie, additional, Gurská, Soňa, additional, Lišková, Barbora, additional, Medvedíková, Martina, additional, Hodek, Ondřej, additional, Tloušťová, Eva, additional, Milisavljevic, Nemanja, additional, Tichý, Michal, additional, Perlíková, Pavla, additional, Mertlíková‐Kaiserová, Helena, additional, Trylčová, Jana, additional, Pohl, Radek, additional, Klepetářová, Blanka, additional, Džubák, Petr, additional, Hajdúch, Marián, additional, and Hocek, Michal, additional

Published
2020
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9. Metallacarborane Sulfamides: Unconventional, Specific, and Highly Selective Inhibitors of Carbonic Anhydrase IX

Author

Grüner, Bohumír, primary, Brynda, Jiří, additional, Das, Viswanath, additional, Šícha, Václav, additional, Štěpánková, Jana, additional, Nekvinda, Jan, additional, Holub, Josef, additional, Pospíšilová, Klára, additional, Fábry, Milan, additional, Pachl, Petr, additional, Král, Vlastimil, additional, Kugler, Michael, additional, Mašek, Vlastimil, additional, Medvedíková, Martina, additional, Matějková, Stanislava, additional, Nová, Alice, additional, Lišková, Barbora, additional, Gurská, Soňa, additional, Džubák, Petr, additional, Hajdúch, Marián, additional, and Řezáčová, Pavlína, additional

Published
2019
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10. Synthesis and Cytotoxic and Antiviral Activity Profiling of All-Four Isomeric Series of Pyrido-Fused 7-Deazapurine Ribonucleosides.

Author

Veselovská L, Kudlová N, Gurská S, Lišková B, Medvedíková M, Hodek O, Tloušťová E, Milisavljevic N, Tichý M, Perlíková P, Mertlíková-Kaiserová H, Trylčová J, Pohl R, Klepetářová B, Džubák P, Hajdúch M, and Hocek M

Subjects
Antineoplastic Agents pharmacology, Antiviral Agents pharmacology, Purines pharmacology, Ribonucleosides pharmacology, Structure-Activity Relationship, Ribonucleosides chemical synthesis
Abstract

All four isomeric series of novel 4-substituted pyrido-fused 7-deazapurine ribonucleosides possessing the pyridine nitrogen atom at different positions were designed and synthesized. The total synthesis of each isomeric fused heterocycle through multistep heterocyclization was followed by glycosylation and derivatization at position 4 by cross-coupling reactions or nucleophilic substitutions. All compounds were tested for cytostatic and antiviral activity. The most active were pyrido[4',3':4,5]pyrimidine nucleosides bearing MeO, NH 2 , MeS, or CH 3 groups at position 4, which showed submicromolar cytotoxic effects and good selectivity for cancer cells. The mechanism involved activation by phosphorylation and incorporation to DNA where the presence of the modified ribonucleosides causes double-strand breaks and apoptosis., (© 2020 Wiley-VCH GmbH.)

Published
2020
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