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12 results on '"Medri, Chiara"'

1. BNT162B2 mRNA COVID-19 Vaccine in Heart and Lung Transplanted Young Adults: Is an Alternative SARS-CoV-2 Immune Response Surveillance Needed?

Author

Cotugno, Nicola, Pighi, Chiara, Morrocchi, Elena, Ruggiero, Alessandra, Amodio, Donato, Medri, Chiara, Colagrossi, Luna, Russo, Cristina, Di Cesare, Silvia, Santilli, Veronica, Manno, Emma Concetta, Zangari, Paola, Giancotta, Carmela, Bernardi, Stefania, Nicolosi, Luciana, Ciofi Degli Atti, Marta, Raponi, Massimiliano, Zaffina, Salvatore, Alfieri, Sara, Kirk, Richard, Perno, Carlo Federico, Rossi, Paolo, Amodeo, Antonio, and Palma, Paolo

Published
2022
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2. How CD4+ T Cells Transcriptional Profile Is Affected by Culture Conditions: Towards the Design of Optimal In Vitro HIV Reactivation Assays

Author

Pascucci, Giuseppe Rubens, primary, Morrocchi, Elena, additional, Pighi, Chiara, additional, Rotili, Arianna, additional, Neri, Alessia, additional, Medri, Chiara, additional, Olivieri, Giulio, additional, Sanna, Marco, additional, Rasi, Gianmarco, additional, Persaud, Deborah, additional, Chahroudi, Ann, additional, Lichterfeld, Mathias, additional, Nastouli, Eleni, additional, Cancrini, Caterina, additional, Amodio, Donato, additional, Rossi, Paolo, additional, Cotugno, Nicola, additional, and Palma, Paolo, additional

Published
2023
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3. Evaluation of Safety and Immunogenicity of BNT162B2 mRNA COVID-19 Vaccine in IBD Pediatric Population with Distinct Immune Suppressive Regimens

Author

Cotugno, Nicola, primary, Franzese, Enrica, additional, Angelino, Giulia, additional, Amodio, Donato, additional, Romeo, Erminia Francesca, additional, Rea, Francesca, additional, Faraci, Simona, additional, Tambucci, Renato, additional, Profeti, Elisa, additional, Manno, Emma Concetta, additional, Santilli, Veronica, additional, Rotulo, Gioacchino Andrea, additional, Pighi, Chiara, additional, Medri, Chiara, additional, Morrocchi, Elena, additional, Colagrossi, Luna, additional, Pascucci, Giuseppe Rubens, additional, Valentini, Diletta, additional, Villani, Alberto, additional, Rossi, Paolo, additional, De Angelis, Paola, additional, and Palma, Paolo, additional

Published
2022
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4. Perinatally Human Immunodeficiency Virus–Infected Adolescents and Young Adults Demonstrate Distinct BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccine Immunogenicity

Author

Morrocchi, Elena, primary, Pighi, Chiara, additional, Pascucci, Giuseppe Rubens, additional, Cotugno, Nicola, additional, Medri, Chiara, additional, Amodio, Donato, additional, Colagrossi, Luna, additional, Ruggiero, Alessandra, additional, Manno, Emma Concetta, additional, Casamento Tumeo, Chiara, additional, Bernardi, Stefania, additional, Smolen, Kinga K, additional, Perno, Carlo Federico, additional, Ozonoff, Al, additional, Rossi, Paolo, additional, Levy, Ofer, additional, and Palma, Paolo, additional

Published
2022
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5. How CD4 + T Cells Transcriptional Profile Is Affected by Culture Conditions: Towards the Design of Optimal In Vitro HIV Reactivation Assays.

Author

Pascucci, Giuseppe Rubens, Morrocchi, Elena, Pighi, Chiara, Rotili, Arianna, Neri, Alessia, Medri, Chiara, Olivieri, Giulio, Sanna, Marco, Rasi, Gianmarco, Persaud, Deborah, Chahroudi, Ann, Lichterfeld, Mathias, Nastouli, Eleni, Cancrini, Caterina, Amodio, Donato, Rossi, Paolo, Cotugno, Nicola, and Palma, Paolo

Subjects
T cells, MONONUCLEAR leukocytes, CD4 antigen, HIV, YOUNG adults
Abstract

Most of the current assays directed at the investigation of HIV reactivation are based on cultures of infected cells such as Peripheral Blood Mononuclear Cells (PBMCs) or isolated CD4+ T cells, stimulated in vitro with different activator molecules. The culture media in these in vitro tests lack many age- and donor-specific immunomodulatory components normally found within the autologous plasma. This triggered our interest in understanding the impact that different matrices and cell types have on T cell transcriptional profiles following in vitro culture and stimulation. Methods: Unstimulated or stimulated CD4+ T cells of three young adults with perinatal HIV-infection were isolated from PBMCs before or after culture in RPMI medium or autologous plasma. Transcriptomes were sequenced using Oxford Nanopore technologies. Results: Transcriptional profiles revealed the activation of similar pathways upon stimulation in both media with a higher magnitude of TCR cascade activation in CD4+ lymphocytes cultured in RPMI. Conclusions: These results suggest that for studies aiming at quantifying the magnitude of biological mechanisms under T cell activation, the autologous plasma could better approximate the in vivo environment. Conversely, if the study aims at defining qualitative aspects, then RPMI culture could provide more evident results. [ABSTRACT FROM AUTHOR]

Published
2023
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6. BNT162B2 mRNA COVID-19 Vaccine in Heart and Lung Transplanted Young Adults: Is an Alternative SARS-CoV-2 Immune Response Surveillance Needed?

Author

Cotugno, Nicola, primary, Pighi, Chiara, additional, Morrocchi, Elena, additional, Ruggiero, Alessandra, additional, Amodio, Donato, additional, Medri, Chiara, additional, Colagrossi, Luna, additional, Russo, Cristina, additional, Di Cesare, Silvia, additional, Santilli, Veronica, additional, Manno, Emma Concetta, additional, Zangari, Paola, additional, Giancotta, Carmela, additional, Bernardi, Stefania, additional, Nicolosi, Luciana, additional, Ciofi Degli Atti, Marta, additional, Raponi, Massimiliano, additional, Zaffina, Salvatore, additional, Alfieri, Sara, additional, Kirk, Richard, additional, Perno, Carlo Federico, additional, Rossi, Paolo, additional, Amodeo, Antonio, additional, and Palma, Paolo, additional

Published
2021
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7. Humoral and Cellular Response Following Vaccination With the BNT162b2 mRNA COVID-19 Vaccine in Patients Affected by Primary Immunodeficiencies

Author

Amodio, Donato, primary, Ruggiero, Alessandra, additional, Sgrulletti, Mayla, additional, Pighi, Chiara, additional, Cotugno, Nicola, additional, Medri, Chiara, additional, Morrocchi, Elena, additional, Colagrossi, Luna, additional, Russo, Cristina, additional, Zaffina, Salvatore, additional, Di Matteo, Gigliola, additional, Cifaldi, Cristina, additional, Di Cesare, Silvia, additional, Rivalta, Beatrice, additional, Pacillo, Lucia, additional, Santilli, Veronica, additional, Giancotta, Carmela, additional, Manno, Emma Concetta, additional, Ciofi Degli Atti, Marta, additional, Raponi, Massimiliano, additional, Rossi, Paolo, additional, Finocchi, Andrea, additional, Cancrini, Caterina, additional, Perno, Carlo Federico, additional, Moschese, Viviana, additional, and Palma, Paolo, additional

Published
2021
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8. Transcriptional and phenotypic analysis of distinct T-cell subsets may reveal novel pathogenetic and diagnostic signatures of Kawasaki disease

Author

Cotugno, Nicola, primary, Sessa, Libera, additional, Pascucci, Giuseppe Rubens, additional, Ruggiero, Alessandra, additional, Di Cesare, Silvia, additional, Amodio, Donato, additional, Ferro, Giuseppina, additional, Medri, Chiara, additional, Buonsenso, Danilo, additional, Chinali, Marcello, additional, D’Anna, Carolina, additional, De Jacobis, Isabella Tarissi, additional, Villani, Alberto, additional, Rossi, Paolo, additional, Marchesi, Alessandra, additional, and Palma, Paolo, additional

Published
2021
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9. VIROLOGICAL AND IMMUNOLOGICAL FEATURES OF SARS-COV-2 INFECTED CHILDREN WITH DISTINCT SYMPTOMATOLOGY

Author

Cotugno, Nicola, primary, Ruggiero, Alessandra, additional, Pascucci, Giuseppe, additional, Bonfante, Francesco, additional, Petrara, Maria, additional, Zicari, Sonia, additional, Cifaldi, Loredana, additional, Zangari, Paola, additional, Bernardi, Stefania, additional, Cursi, Laura, additional, Medri, Chiara, additional, Santilli, Veronica, additional, Manno, Emma, additional, Amodio, Donato, additional, Linardos, Giulia, additional, Piccioni, Livia, additional, Barbieri, Maria, additional, Perrotta, Daniela, additional, Campana, Andrea, additional, Donà, Daniele, additional, Giaquinto, Carlo, additional, Team, Cactus Study, additional, Concato, Carlo, additional, Brodin, Petter, additional, Rossi, Paolo, additional, Rossi, Anita De, additional, and Palma, Paolo, additional

Published
2021
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10. Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies

Author

Cotugno, Nicola, primary, Ruggiero, Alessandra, additional, Bonfante, Francesco, additional, Petrara, Maria Raffaella, additional, Zicari, Sonia, additional, Pascucci, Giuseppe Rubens, additional, Zangari, Paola, additional, De Ioris, Maria Antonietta, additional, Santilli, Veronica, additional, Manno, E.C., additional, Amodio, Donato, additional, Bortolami, Alessio, additional, Pagliari, Matteo, additional, Concato, Carlo, additional, Linardos, Giulia, additional, Campana, Andrea, additional, Donà, Daniele, additional, Giaquinto, Carlo, additional, Brodin, Petter, additional, Rossi, Paolo, additional, De Rossi, Anita, additional, Palma, Paolo, additional, Bernardi, Stefania, additional, Romani, Lorenza, additional, Pansa, Paola, additional, Chiurchiú, Sara, additional, Finocchi, Andrea, additional, Cancrini, Caterina, additional, Lancella, Laura, additional, Cursi, Laura, additional, De Luca, Maia, additional, Cutrera, Renato, additional, Sessa, Libera, additional, Morrocchi, Elena, additional, Medri, Chiara, additional, Putignani, Lorenza, additional, Calò Carducci, F.I., additional, D’Argenio, Patrizia, additional, Ciofi degli Atti, Marta, additional, D’Amore, Carmen, additional, Piccioni, Livia, additional, Di Giuseppe, Martina, additional, Jenkner, Alessandro, additional, Giancotta, Carmela, additional, and Krzysztofiak, Andrzej, additional

Published
2021
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