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The editorial in the journal "Bioengineering" discusses the challenges posed by maxillofacial defects and the limitations of current treatments involving autologous bone grafts and prosthetic devices. The editorial highlights innovative approaches such as using biomaterials combined with stem cells for bone regeneration, exploring the impact of sintering temperatures on bone graft properties, and utilizing laser-assisted surface patterning to enhance cell organization. Reviews in the article focus on the potential of silica-based inks in 3D printing for bone tissue engineering and the use of nanomaterials in periodontal tissue engineering. Additionally, the article discusses the use of laser soldering technology for soft tissue reconstruction and a novel imaging technique for early detection of dental caries. The future of maxillofacial defect treatment lies in personalized approaches, advanced technologies, and regenerative medicine to improve patient outcomes and advance clinical practice. [Extracted from the article]