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38. Chapter Digital Transitions for a Comprehensive 3D Documentation: European Trends for Heritage Preservation

Author

Maietti, Federica and Medici, Marco

Subjects
Transitions, Cross, Modulate, Develop, Drawing, Science of Representation, thema EDItEUR::A The Arts::AM Architecture::AMC Architectural structure and design, thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBG Engineering graphics and draughting / technical drawing, thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGZ The Arts: techniques and principles
Abstract

The volume, dedicated to the 44th International Conference of the Italian Union for Drawing, investigates the theme of ‘Transitions’, which particularly effectively represents our time and the current condition of the discipline of Drawing. The term, beyond its generic meaning of an intermediate stage in a process in which a condition changes from one state to another, has always been used in various fields, from music to geophysics. In fact, the disciplines of drawing have always been confronted with themes and issues relating to transitions from one condition to another. The history of representation tells us of transformations, even epochal ones, relating to ‘drawing’, with all that such transitions entail: suffice it to think of the evolution of forms of representation, of instrumental apparatuses, of the mutability of supports, of the analogical-digital transition underway, of the new modes of communication on platforms, of the hypertrophic offer of images also on the net that confirms Guy Debord’s intuitions relating to the new spectacularisation of society. Similarly, representation triggers transitions in the prefiguration and communication of design, the anticipation and foreshadowing of future events.The challenges posed by the digital pose open questions whose scope can only be glimpsed, such as the relationship between drawing and the act of modelling, and the construction of new paradigms of visual language and communication. ‘Transitions’, almost implicitly, points to possible futures, the evolution of technique and the search for new modes of expression; at the same time, however, it can suggest silences and reflections in a process of connection between history, theory, criticism and construction.

Published
2023
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39. Preparation and in vitro function of granulocyte concentrates for transfusion to neonates using the IBM 2991 blood processor

Author

Hsi R, Connelly M, Goldfinger D, Medici Ma, and McPherson J

Subjects
Neutrophils, medicine.medical_treatment, IBM 2991, Phagocytosis, Immunology, Infant, Newborn, Cell Separation, Hematology, Leukapheresis, Biology, Granulocyte, In vitro, Blood cell, medicine.anatomical_structure, medicine, Humans, Immunology and Allergy, Blood Transfusion, Saline, Granulocytes, Whole blood
Abstract

Clinical studies have suggested that granulocyte transfusions may be of value in the treatment of septic neonatal patients who present with severe granulocytopenia. We have developed a protocol for the preparation of granulocyte concentrates from freshly collected units of whole blood, using an automated blood cell processor. The red cells were washed with saline. Then, the buffy coats were collected from the washed red cells and studied for their suitability as granulocyte concentrates for neonatal transfusion. The mean number of granulocytes per concentrate was 1.6 X 10(9) in a mean volume of 25 ml. Studies of granulocyte function, including viability, random mobility, chemotaxis, phagocytosis and nitro-blue tetrazolium reduction, demonstrated that the granulocytes were functionally unimpaired following preparation of the concentrates. These studies suggest that concentrates of functional granulocytes, suitable for transfusion to neonatal patients, can be prepared from fresh units of whole blood, using a cell processor. This procedure is more cost-effective than leukapheresis and allows for delivery of granulocytes for transfusion in a more timely fashion.

Published
1983
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40. Pneumocystis carinii Pneumonia in an Apparently Nonimmunocompromised Patient

Author

Smith S, Lee S, Medici Ma, Mohsenifar Z, and Goldbach Pd

Subjects
Adult, Male, business.industry, medicine.drug_class, Pneumonia, Pneumocystis, T-Lymphocytes, Sulfamethoxazole, Antibiotics, General Medicine, medicine.disease, Protein-Energy Malnutrition, Trimethoprim, Virology, Microbiology, Pneumonia, Pneumocystis carinii, Candidiasis, Oral, Cytomegalovirus Infections, medicine, Humans, business, medicine.drug
Published
1982
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45. Chapter H-BIM semantico come strumento di documentazione inclusiva e accesso al Nuovo Catalogo Digitale dei Beni Culturali: il caso studio di Santa Maria delle Vergini a Macerata

Author

Medici, Marco, Ferrari, Federico, and Sterpin, Andrea

Subjects
Discipline of representation, History, Semiotics, Science, Technology, thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTD Semiotics / semiology, thema EDItEUR::N History and Archaeology::NH History, thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society
Abstract

The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences.

Published
2022
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46. How to face the scientific communication today. International challenge and digital technology impact on research outputs dissemination

Author

Medici, Marco, Modugno, Valentina, and Pracucci, Alessandro

Subjects
bic Book Industry Communication::A The arts::AM Architecture, bic Book Industry Communication::A The arts::AM Architecture::AMA Theory of architecture, bic Book Industry Communication::A The arts::AM Architecture::AMC Architectural structure & design, bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues, bic Book Industry Communication::T Technology, engineering, agriculture::TT Other technologies & applied sciences
Abstract

Dissemination of scientific results is an important and necessary component of research activity. Nowadays research asks to be widely diffused and shared in a larger community in the effort to demonstrate its innovation and originality, so to enlarge network and obtain funds to keep working. In this context, PhD students, as part of scientific community and young researchers in training, have to understand the rule of publications to define the best strategy for the dissemination of their research. The present book, through the experiences of national and international PhD candidates, PhDs and Professors, is a contribute in the current opened debate on the most effective strategies and related tools to design specific actions, to highlight and improve the peculiar qualities and disciplines of each research.

Published
2017
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47. Genetic diversity of Candida albicans isolates recovered from hospital environments and patients with severe acquired brain injuries.

Author

Scordino F, Giuffrè L, Felice MR, Orlando MG, Medici MA, Marino Merlo F, and Romeo O

Subjects
Candida albicans genetics, Candida albicans isolation & purification, Candidiasis epidemiology, Environmental Microbiology, Evolution, Molecular, Female, Genetic Variation, Hand microbiology, Health Personnel, Humans, Male, Mycological Typing Techniques, Phylogeny, Brain Injuries microbiology, Candida albicans classification, Candidiasis diagnosis, Multilocus Sequence Typing methods
Abstract

Although the epidemiology of pathogenic Candida species causing invasive human diseases is changing, Candida albicans still remains the most common cause of bloodstream infections worldwide. The propensity of this pathogen to cause infections is undoubtedly the result of its unique genetic plasticity that allow it to adapt and respond quickly to a myriad of changing conditions both in the host and in the environment. For this reason, we decided to investigate the genetic diversity of this important fungal pathogen in a particular category of patients with severe neurological deficits including the hospital environments where they are hospitalized. Genetic diversity of 21 C. albicans isolates recovered from blood, hands of healthcare workers and hospital environments was evaluated by using multilocus sequence typing (MLST) which revealed a high genetic heterogeneity with a set of 18 diploid sequence types (DSTs) recovered among 21 isolates investigated. Interestingly, 13 of these 18 MLST genotypes were completely new and added to the C. albicans MLST central database. Six eBURST clonal complexes (CC-1, CC-2, CC-6, CC-9, CC-27 and CC-42) and three singletons contained all DSTs found in this study. Among all the new DSTs identified, DST3388 was the most intriguing as this genotype was recovered from a typical C. albicans isolate clustering within the MLST-Clade 13, the most divergent evolutionary lineage within C. albicans population containing only isolates with unusual phenotypes originally known as Candida africana. In conclusion, the results of this study expand our understanding of the molecular epidemiology and global population structure of C. albicans suggesting that further studies on different categories of patients and hospital environments are needed to better understand how the population of this species adapts and evolves in heterogeneous hosts and changing environments., (Copyright © 2019 Elsevier B.V. All rights reserved.)

Published
2019
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48. HSV-1\EGFP stimulates miR-146a expression in a NF-κB-dependent manner in monocytic THP-1 cells.

Author

Venuti A, Musarra-Pizzo M, Pennisi R, Tankov S, Medici MA, Mastino A, Rebane A, and Sciortino MT

Subjects
Animals, Chlorocebus aethiops, Green Fluorescent Proteins metabolism, Herpesvirus 1, Human genetics, Herpesvirus 1, Human growth & development, Humans, Interleukin-1 Receptor-Associated Kinases metabolism, MicroRNAs genetics, Mutation genetics, Phosphorylation, THP-1 Cells, Vero Cells, Virus Replication physiology, Herpesvirus 1, Human physiology, MicroRNAs metabolism, Monocytes metabolism, NF-kappa B metabolism
Abstract

The nuclear factor κB (NF-κB) pathway plays a key role in innate and adaptive immunity, cell proliferation and survival, inflammation and tumors development. MiR-146a is an immune system regulator that has anti-inflammatory function in multiple cell types and conditions. Here we demonstrate activation of canonical NF-κB pathway in monocytic cells upon HSV-1 replication. By constructing and using a recombinant HSV-1\EGFP virus, we monitored the capability of the virus to recruit NF-κB and we report that the phosphorylation of p65 protein correlates with an active virus replication at single-cell level. In addition, we found that upregulation of miR-146a during viral replication is strictly dependent on NF-κB activation and correlates with tight control of the interleukin-1 receptor-associate kinase 1 (IRAK1). Accordingly, THP-1 DN IκBα cells, expressing a dominant negative mIκBα, did not show upregulation of miR-146a upon HSV-1 infection. Our data suggest that the expression of miRNA-146a modulates NF-κB activation through targeting IRAK1 during HSV-1 replication in THP-1 cells.

Published
2019
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49. Opposite actions of urotensin II and relaxin-2 on cellular expression of fibronectin in renal fibrosis: A preliminary experimental study.

Author

Cernaro V, Medici MA, Bianco F, Santoro D, Lacquaniti A, Romeo A, Lucisano S, Buemi A, and Buemi M

Subjects
Animals, Disease Models, Animal, Fibrosis, Humans, Male, Swine, Fibronectins metabolism, Gene Expression Regulation drug effects, Kidney drug effects, Kidney pathology, Relaxin pharmacology, Urotensins pharmacology
Abstract

Our aim was to evaluate the role of urotensin II, urantide (urotensin II receptor antagonist) and relaxin-2 on the cellular expression of fibronectin as a surrogate marker for renal fibrosis. We employed LLC-PK1 renal tubular epithelial cells and assessed the influence on the fibrotic process of the above-mentioned substances by using anti-fibronectin antibodies in western blot analysis. The addition of urotensin II increased fibronectin expression. Urantide reduced the positivity for fibronectin caused by urotensin II (P<.05). The anti-fibrotic action was more evident for relaxin-2 (P<.01). Also in the model of TGF-β1-induced fibrosis, urantide and, to a greater extent, relaxin-2 were able to significantly lessen fibronectin expression (respectively, P<.05 and P<.01). In conclusion, relaxin-2 may reduce urotensin II-induced renal fibrosis., (© 2017 John Wiley & Sons Australia, Ltd.)

Published
2017
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50. HSV-1-induced activation of NF-κB protects U937 monocytic cells against both virus replication and apoptosis.

Author

Marino-Merlo F, Papaianni E, Medici MA, Macchi B, Grelli S, Mosca C, Borner C, and Mastino A

Subjects
Animals, Antibodies, Neutralizing pharmacology, DNA metabolism, Fluorescent Antibody Technique, Gene Expression Profiling, Humans, I-kappa B Proteins metabolism, Immunity, Innate drug effects, Immunity, Innate genetics, Interferon-alpha pharmacology, Intracellular Membranes metabolism, Lysosomes drug effects, Lysosomes metabolism, Mice, Monocytes drug effects, Permeability, Protein Binding drug effects, Transfection, Tumor Necrosis Factor-alpha pharmacology, U937 Cells, Apoptosis drug effects, Cytoprotection drug effects, Herpesvirus 1, Human physiology, Monocytes cytology, Monocytes virology, NF-kappa B metabolism, Virus Replication drug effects
Abstract

The transcription factor nuclear factor-kappa B (NF-κB) is a crucial player of the antiviral innate response. Intriguingly, however, NF-κB activation is assumed to favour herpes simplex virus (HSV) infection rather than restrict it. Apoptosis, a form of innate response to viruses, is completely inhibited by HSV in fully permissive cells, but not in cells incapable to fully sustain HSV replication, such as immunocompetent cells. To resolve the intricate interplay among NF-κB signalling, apoptosis and permissiveness to HSV-1 in monocytic cells, we utilized U937 monocytic cells in which NF-κB activation was inhibited by expressing a dominant-negative IκBα. Surprisingly, viral production was increased in monocytic cells in which NF-κB was inhibited. Moreover, inhibition of NF-κB led to increased apoptosis following HSV-1 infection, associated with lysosomal membrane permeabilization. High expression of late viral proteins and induction of apoptosis occurred in distinct cells. Transcriptional analysis of known innate response genes by real-time quantitative reverse transcription-PCR excluded a contribution of the assayed genes to the observed phenomena. Thus, in monocytic cells NF-κB activation simultaneously serves as an innate process to restrict viral replication as well as a mechanism to limit the damage of an excessive apoptotic response to HSV-1 infection. This finding may clarify mechanisms controlling HSV-1 infection in monocytic cells.

Published
2016
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