237 results on '"Medhurst, A. D."'
Search Results
2. Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease
3. SB 203186, A Potent 5-HT4 Antagonist for Cardiac 5-HT4 Receptors
4. Autoradiographical imaging of PPARγ agonist effects on PBR/TSPO binding in TASTPM mice
5. Identification of a novel 5-HT 4 receptor splice variant (r5-HT 4c1) and preliminary characterisation of specific 5-HT 4a and 5-HT 4b receptor antibodies
6. Novel histamine H 3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain
7. Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040
8. Structurally novel histamine H 3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats
9. H3 Receptor Target: Past, Present, and Future Perspectives from Worldwide H3 Experts
10. Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2
11. Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinsonʼs disease
12. Heterogeneity of histaminergic neurons in the tuberomammillary nucleus of the rat
13. Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep–wake cycle and narcoleptic episodes in Ox−/− mice
14. Characterization of histamine H3 receptors in Alzheimerʼs Disease brain and amyloid over-expressing TASTPM mice
15. Identification of a novel 5-HT4 receptor splice variant (r5-HT4c1) and preliminary characterisation of specific 5-HT4a and 5-HT4b receptor antibodies
16. Simultaneous measurement of [3H]noradrenaline release and neurogenic contraction under identical conditions, to determine the prejunctional inhibitory effects of SKF 99101H and BRL 56905 in dog saphenous vein
17. The PPARγ agonist pioglitazone is effective in the MPTP mouse model of Parkinsonʼs disease through inhibition of monoamine oxidase B
18. Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats
19. MPTP treatment of common marmosets impairs proteasomal enzyme activity and decreases expression of structural and regulatory elements of the 26S proteasome
20. Effects of 6-hydroxydopamine on pre- and post-junctional 5-HT1-like receptor-mediated responses in dog saphenous vein
21. The GABA B2 subunit is critical for the trafficking and function of native GABA B receptors
22. The GABAB2 subunit is critical for the trafficking and function of native GABAB receptors
23. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin
24. Cloning and Functional Expression of Human Short TRP7, a Candidate Protein for Store-operated Ca2+ Influx
25. mRNA distribution analysis of human TRPC family in CNS and peripheral tissues
26. Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery
27. Quantitative mRNA analysis of five C-terminal splice variants of the human 5-HT 4 receptor in the central nervous system by TaqMan real time RT-PCR
28. Cloning and Characterization of Human NTT5 and v7-3: Two Orphan Transporters of the Na+/Cl−-Dependent Neurotransmitter Transporter Gene Family
29. Cloning and functional expression of a human orthologue of rat vanilloid receptor-1
30. The use of quantitative RT-PCR to measure mRNA expression in a rat model of focal ischemia — caspase-3 as a case study
31. The use of TaqMan RT-PCR assays for semiquantitative analysis of gene expression in CNS tissues and disease models
32. Medical Audit In North America
33. Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists
34. The discovery of the benzazepine class of histamine H3 receptor antagonists
35. Regional Differential Effects of the Novel Histamine H3 Receptor Antagonist 6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) on Histamine Release in the Central Nervous System of Freely Moving Rats
36. Application of TaqMan RT-PCR for Real-Time Semiquantitative Analysis of Gene Expression in the Striatum
37. Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors
38. Molecular and pharmacological characterization of a functional tachykinin NK3 receptor cloned from the rabbit iris sphincter muscle
39. Tricyclic azepine derivatives as selective brain penetrant 5-HT 6 receptor antagonists
40. Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor
41. Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors
42. 11C-GSK189254: A Selective Radioligand for In Vivo Central Nervous System Imaging of Histamine H3 Receptors by PET
43. H3 Receptor Antagonism Enhances NCAM PSA-Mediated Plasticity and Improves Memory Consolidation in Odor Discrimination and Delayed Match-to-Position Paradigms
44. Tricyclic azepine derivatives as selective brain penetrant 5-HT6 receptor antagonists
45. Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040
46. Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain
47. P4-327: Effects of the novel 5-HT6 SB-742457 antagonist and the cholinesterase inhibitor donepezil in models of cognition
48. The novel cyclooxygenase-2 inhibitor GW637185X protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity
49. GSK189254, a Novel H3 Receptor Antagonist That Binds to Histamine H3 Receptors in Alzheimer's Disease Brain and Improves Cognitive Performance in Preclinical Models
50. O3-05-01
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