Search

Your search keyword '"Meder, B."' showing total 369 results
Start Over Author "Meder, B."
369 results on '"Meder, B."'

8. Gene diagnostics for cardiovascular diseases

Author

Schulze-Bahr, E., primary, Klaassen, S., additional, Gerull, B., additional, von Kodolitsch, Y., additional, Landmesser, U., additional, Rieß, O., additional, Meder, B., additional, and Schunkert, H., additional

Published
2023
Full Text
View/download PDF

9. Visual-spatial dynamics drive adaptive social learning in immersive environments

Author

Wu, C., https://orcid.org/0000-0002-2215-572X, Deffner, D., Kahl, B., Meder, B., Ho, M., and Kurvers, R.

Abstract

Humans are uniquely capable social learners. Our capacity to learn from others across short and long timescales is a driving force behind the success of our species. Yet there are seemingly maladaptive patterns of human social learning, characterized by both overreliance and underreliance on social information. Recent advances in animal research have incorporated rich visual and spatial dynamics to study social learning in ecological contexts, showing how simple mechanisms can give rise to intelligent group dynamics. However, similar techniques have yet to be translated into human research, which additionally requires integrating the sophistication of human individual and social learning mechanisms. Thus, it is still largely unknown how humans dynamically adapt social learning strategies to different environments and how group dynamics emerge under realistic conditions. Here, we use a collective foraging experiment in an immersive Minecraft environment to provide unique insights into how visual-spatial interactions give rise to adaptive, specialized, and selective social learning. Our analyses show how groups adapt to the demands of the environment through specialization rather than homogeneity and through the adaptive deployment of selective imitation rather than indiscriminate copying. We test these mechanisms using computational modeling, providing a deeper understanding of the cognitive mechanisms that dynamically influence social decision-making in ecological contexts. Specialization of learning strategies and selective attention thus offer insights into the adaptive foundations of human social learning.

Published
2023

11. Developmental changes in learning resemble stochastic optimization

Author

Giron, A., Ciranka, S., Schulz, E., van den Bos, W., Ruggeri, A., https://orcid.org/0000-0002-0839-1929, Meder, B., and Wu, C.

Abstract

Analogies to stochastic optimization are common in developmental psychology, describing a gradual reduction in randomness over the lifespan. Yet for lack of concrete empirical comparison, there is ambiguity in how to interpret this analogy. Using data from n=281 participants ages 5 to 55, we show that "cooling off'" does not only apply to the single dimension of randomness. Rather, development resembles a stochastic optimization process in the space of learning strategies, which we characterize along key dimensions of reward generalization, uncertainty-directed exploration, and random temperature. What begins as large tweaks in the parameters that define learning during childhood, plateaus and converges in adulthood. The developmental trajectory of human parameters is strikingly similar to several stochastic optimization algorithms, yet we begin to observe a divergence around adolescence. Remarkably, none of the optimization algorithms discovered reliably better regions of the strategy space than adult participants, suggesting an incredible efficiency of human development.

Published
2023

12. Decrease of RNA editing in the failing heart leads to induction of circRNAs

Author

Kokot, K, primary, Kneuer, J, additional, John, D, additional, Rebs, S, additional, Mueller, M, additional, Haas, J, additional, Thiele, H, additional, Mueller, O J, additional, Hille, S, additional, Leuschner, F, additional, Dimmeler, S, additional, Streckfuss-Boemeke, K, additional, Meder, B, additional, Laufs, U, additional, and Boeckel, J N, additional

Published
2022
Full Text
View/download PDF

13. Natural History of MYH7-Related Dilated Cardiomyopathy

Author

Frutos, F. de, Ochoa, J.P., Navarro-Peñalver, M., Baas, A, Bjerre, J.V., Zorio, E., Méndez, I., Lorca, R., Verdonschot, J.A.J., García-Granja, P.E., Bilinska, Z., Fatkin, D., Fuentes-Cañamero, M.E., García-Pinilla, J.M., García-Álvarez, M.I., Girolami, F., Barriales-Villa, R., Díez-López, C., Lopes, L.R., Wahbi, K., García-Álvarez, A., Rodríguez-Sánchez, I., Rekondo-Olaetxea, J., Rodríguez-Palomares, J.F., Gallego-Delgado, M., Meder, B., Kubanek, M., Hansen, F.G., Restrepo-Córdoba, M.A., Palomino-Doza, J., Ruiz-Guerrero, L., Sarquella-Brugada, G., Perez-Perez, A.J., Bermúdez-Jiménez, F.J., Ripoll-Vera, T., Rasmussen, T.B., Jansen, Mark, Sabater-Molina, M., Brunner, H.G., Elliot, P.M., Garcia-Pavia, P., Frutos, F. de, Ochoa, J.P., Navarro-Peñalver, M., Baas, A, Bjerre, J.V., Zorio, E., Méndez, I., Lorca, R., Verdonschot, J.A.J., García-Granja, P.E., Bilinska, Z., Fatkin, D., Fuentes-Cañamero, M.E., García-Pinilla, J.M., García-Álvarez, M.I., Girolami, F., Barriales-Villa, R., Díez-López, C., Lopes, L.R., Wahbi, K., García-Álvarez, A., Rodríguez-Sánchez, I., Rekondo-Olaetxea, J., Rodríguez-Palomares, J.F., Gallego-Delgado, M., Meder, B., Kubanek, M., Hansen, F.G., Restrepo-Córdoba, M.A., Palomino-Doza, J., Ruiz-Guerrero, L., Sarquella-Brugada, G., Perez-Perez, A.J., Bermúdez-Jiménez, F.J., Ripoll-Vera, T., Rasmussen, T.B., Jansen, Mark, Sabater-Molina, M., Brunner, H.G., Elliot, P.M., and Garcia-Pavia, P.

Abstract

Contains fulltext : 287886.pdf (Publisher’s version ) (Open Access), BACKGROUND: Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES: We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS: We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 ± 19.2 years) recruited from 29 international centers. RESULTS: At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% ± 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of ≤35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS: MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare.

Published
2022

15. RBM20-related cardiomyopathy: current understanding and future options

Author

Koelemen, J., Gotthardt, M., Steinmetz, L.M., and Meder, B.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

Splice regulators play an essential role in the transcriptomic diversity of all eukaryotic cell types and organ systems. Recent evidence suggests a contribution of splice-regulatory networks in many diseases, such as cardiomyopathies. Adaptive splice regulators, such as RNA-binding motif protein 20 (RBM20) determine the physiological mRNA landscape formation, and rare variants in the RBM20 gene explain up to 6% of genetic dilated cardiomyopathy (DCM) cases. With ample knowledge from RBM20-deficient mice, rats, swine and induced pluripotent stem cells (iPSCs), the downstream targets and quantitative effects on splicing are now well-defined and the prerequisites for corrective therapeutic approaches are set. This review article highlights some of the recent advances in the field, ranging from aspects of granule formation to 3D genome architectures underlying RBM20-related cardiomyopathy. Promising therapeutic strategies are presented and put into context with the pathophysiological characteristics of RBM20-related diseases.

Published
2021

16. Diagnostic value of circulating microRNAs compared to high-sensitivity troponin T for the detection of non-ST-segment elevation myocardial infarction

Author

Biener, M, primary, Giannitsis, E G, additional, Thum, T, additional, Baer, C, additional, Costa, A, additional, Andrzejewski, T, additional, Stoyanov, K M, additional, Vafaie, M, additional, Meder, B, additional, Katus, H A, additional, De Gonzalo Calvo, D, additional, and Mueller-Hennessen, M, additional

Published
2021
Full Text
View/download PDF

17. The human cell atlas of the hypertrophic heart reveals impaired inter-cellular cross-talks

Author

Nicin, L, primary, Bruening, R S, additional, Kattih, B, additional, Glaser, S F, additional, Abplanalp, W T, additional, Schroeter, S M, additional, Arsalan, M, additional, Holubec, T, additional, Emrich, F, additional, Meder, B, additional, Reich, C, additional, Walther, T, additional, Zeiher, A M, additional, John, D, additional, and Dimmeler, S, additional

Published
2021
Full Text
View/download PDF

19. Reduced RNA editing in the failing human heart mediates alternative circular RNA splicing

Author

Kokot, K, primary, Kneuer, J, additional, John, D, additional, Moebius-Winkler, M, additional, Mueller, M, additional, Andritschke, M, additional, Gaul, S, additional, Sheikh, B, additional, Haas, J, additional, Thiele, H, additional, Leuschner, F, additional, Dimmeler, S, additional, Meder, B, additional, Laufs, U, additional, and Boeckel, J N, additional

Published
2021
Full Text
View/download PDF

20. The long non-coding RNA Heat4 is upregulated in heart failure and decreases the immune response of non-classical monocytes

Author

Kneuer, J, primary, Meinecke, T, additional, Weiss, R, additional, Gaul, S, additional, Haas, J, additional, Meder, B, additional, Garfias-Veitel, T, additional, Von Haehling, S, additional, Kogel, A, additional, Keller, T, additional, Speer, T, additional, Thiele, H, additional, Lurz, P, additional, Laufs, U, additional, and Boeckel, J.-N, additional

Published
2021
Full Text
View/download PDF

23. What makes a good query? Prospects for a comprehensive theory of human information acquisition

Author

Crupi, Nelson Jd, and Meder B

Subjects
Information retrieval, Text mining, Computer science, business.industry, Information acquisition, business
Abstract

Searching for information in a goal-directed manner is central for learning, diagnosis, and prediction. Children continuously ask questions to learn new concepts, doctors do medical tests to diagnose their patients, and scientists perform experiments to test their theories. But what makes a good question? What principles govern human information acquisition and how do people decide which query to conduct to achieve their goals? What challenges need to be met to advance theory and psychology of human inquiry? Addressing these issues, we introduce the conceptual and mathematical ideas underlying different models of the value of information, what purpose these models serve in psychological research, and how they can be integrated in a unified formal framework. We also discuss the conflict between short- and long-term efficiency of prominent methods for query selection, and the resulting normative and methodological implications for studying human sequential search. A final point of discussion concerns the relations between probabilistic (Bayesian) models of the value of information and heuristic search strategies, and the insights than can be gained from bridging different levels of analysis and types of models. We conclude by discussing open questions and challenges that research needs to address to build a comprehensive theory of human information acquisition.

Published
2021
Full Text
View/download PDF

25. Prevalence and clinical outcomes of dystrophin-associated dilated cardiomyopathy without severe skeletal myopathy

Author

Restrepo-Cordoba M, Wahbi K, Florian A, Jimenez-Jaimez J, Politano L, Arad M, Climent-Paya V, Garcia-Alvarez A, Hansen R, Larranaga-Moreira J, Kubanek M, Lopes L, Ros A, Jurcut R, Rasmussen T, Ruiz-Guerrero L, Pribe-Wolferts R, Palomino-Doza J, Bilinska Z, Rodriguez-Palomares J, Van Loon R, Elorz M, Quarta G, Inarritu M, Verdonschot J, Stojkovic T, Shomanova Z, Bermudez-Jimenez F, Palladino A, Freimark D, Garcia-Alvarez M, Jorda P, Dominguez F, Ochoa J, Girolami F, Brugada R, Meder B, Barriales-Villa R, Mogensen J, Laforet P, Yilmaz A, Elliott P, Garcia-Pavia P, and European Genetic Cardiomyopathies

Subjects
Dystrophin, Myopathy, DMD, cardiovascular system, Dilated cardiomyopathy, Heart failure, cardiovascular diseases, musculoskeletal system, complex mixtures
Abstract

Aims Dilated cardiomyopathy (DCM) associated with dystrophin gene (DMD) mutations in individuals with mild or absent skeletal myopathy is often indistinguishable from other DCM forms. We sought to describe the phenotype and prognosis of DMD associated DCM in DMD mutation carriers without severe skeletal myopathy. Methods and results At 26 European centres, we retrospectively collected clinical characteristics and outcomes of 223 DMD mutation carriers (83% male, 33 +/- 15 years). A total of 112 individuals (52%) had DCM at first evaluation [n = 85; left ventricular ejection fraction (LVEF) 34 +/- 11.2%] or developed DCM (n = 27; LVEF 41.3 +/- 7.5%) after a median follow-up of 96 months (interquartile range 5-311 months). DCM penetrance was 45% in carriers older than 40 years. DCM appeared earlier in males and was independent of the type of mutation, presence of skeletal myopathy, or elevated serum creatine kinase levels. Major adverse cardiac events (MACE) occurred in 22% individuals with DCM, 18% developed end-stage heart failure and 9% sudden cardiac death or equivalent. Skeletal myopathy was not associated with survival free of MACE in patients with DCM. Decreased LVEF and increased left ventricular end-diastolic diameter at baseline were associated with MACE. Individuals without DCM had favourable prognosis without MACE or death during follow-up. Conclusions DMD-associated DCM without severe skeletal myopathy is characterized by incomplete penetrance but high risk of MACE, including progression to end-stage heart failure and ventricular arrhythmias. DCM onset is the major determinant of prognosis with similar survival regardless of the presence of skeletal myopathy.

Published
2021

26. Deep assessment of human disease-associated ribosomal RNA modifications using Nanopore direct RNA sequencing - doi: https://doi.org/10.1101/2021.11.10.467884

Author

Naarman - de Vries, Isabel S., Zorbas, Christiane, Lemsara, Amina, Bencun, M, Schudy, S, Meder, B, Eschenbach, Jessica, Lafontaine, Denis, Dieterich, Christoph, Naarman - de Vries, Isabel S., Zorbas, Christiane, Lemsara, Amina, Bencun, M, Schudy, S, Meder, B, Eschenbach, Jessica, Lafontaine, Denis, and Dieterich, Christoph

Abstract

info:eu-repo/semantics/published

Published
2021

27. Impact of atrial fibrillation on outcome in takotsubo syndrome: Data from the international Takotsubo registry

Author

El-Battrawy, I., Cammann, V. L., Kato, K., Szawan, K. A., Di Vece, D., Rossi, A., Wischnewsky, M., Hermes-Laufer, J., Gili, S., Citro, R., Bossone, E., Neuhaus, M., Franke, J., Meder, B., Jaguszewski, M., Noutsias, M., Knorr, M., Heiner, S., D'Ascenzo, F., Dichtl, W., Burgdorf, C., Kherad, B., Tschope, C., Sarcon, A., Shinbane, J., Rajan, L., Michels, G., Pfister, R., Cuneo, A., Jacobshagen, C., Karakas, M., Koenig, W., Pott, A., Meyer, P., Arroja, J. D., Banning, A., Cuculi, F., Kobza, R., Fischer, T. A., Vasankari, T., Juhani Airaksinen, K. E., Napp, L. C., Budnik, M., Dworakowski, R., Maccarthy, P., Kaiser, C., Osswald, S., Galiuto, Leonarda, Chan, C., Bridgman, P., Beug, D., Delmas, C., Lairez, O., Gilyarova, E., Shilova, A., Gilyarov, M., Kozel, M., Tousek, P., Winchester, D. E., Galuszka, J., Ukena, C., Poglajen, G., Carrilho-Ferreira, P., Hauck, C., Paolini, C., Bilato, C., Kobayashi, Y., Prasad, A., Rihal, C. S., Liu, K., Schulze, P. C., Bianco, M., Jorg, L., Rickli, H., Pestana, G., Nguyen, T. H., Bohm, M., Maier, L. S., Pinto, F. J., Widimsky, P., Felix, S. B., Opolski, G., Braun-Dullaeus, R. C., Rottbauer, W., Hasenfuss, G., Pieske, B. M., Schunkert, H., Thiele, H., Bauersachs, J., Katus, H. A., Horowitz, J. D., Di Mario, C., Munzel, T., Crea, Filippo, Bax, J. J., Luscher, T. F., Ruschitzka, F., Duru, F., Borggrefe, M., Ghadri, J. R., Akin, I., Templin, C., Galiuto L. (ORCID:0000-0002-6831-479X), Crea F. (ORCID:0000-0001-9404-8846), El-Battrawy, I., Cammann, V. L., Kato, K., Szawan, K. A., Di Vece, D., Rossi, A., Wischnewsky, M., Hermes-Laufer, J., Gili, S., Citro, R., Bossone, E., Neuhaus, M., Franke, J., Meder, B., Jaguszewski, M., Noutsias, M., Knorr, M., Heiner, S., D'Ascenzo, F., Dichtl, W., Burgdorf, C., Kherad, B., Tschope, C., Sarcon, A., Shinbane, J., Rajan, L., Michels, G., Pfister, R., Cuneo, A., Jacobshagen, C., Karakas, M., Koenig, W., Pott, A., Meyer, P., Arroja, J. D., Banning, A., Cuculi, F., Kobza, R., Fischer, T. A., Vasankari, T., Juhani Airaksinen, K. E., Napp, L. C., Budnik, M., Dworakowski, R., Maccarthy, P., Kaiser, C., Osswald, S., Galiuto, Leonarda, Chan, C., Bridgman, P., Beug, D., Delmas, C., Lairez, O., Gilyarova, E., Shilova, A., Gilyarov, M., Kozel, M., Tousek, P., Winchester, D. E., Galuszka, J., Ukena, C., Poglajen, G., Carrilho-Ferreira, P., Hauck, C., Paolini, C., Bilato, C., Kobayashi, Y., Prasad, A., Rihal, C. S., Liu, K., Schulze, P. C., Bianco, M., Jorg, L., Rickli, H., Pestana, G., Nguyen, T. H., Bohm, M., Maier, L. S., Pinto, F. J., Widimsky, P., Felix, S. B., Opolski, G., Braun-Dullaeus, R. C., Rottbauer, W., Hasenfuss, G., Pieske, B. M., Schunkert, H., Thiele, H., Bauersachs, J., Katus, H. A., Horowitz, J. D., Di Mario, C., Munzel, T., Crea, Filippo, Bax, J. J., Luscher, T. F., Ruschitzka, F., Duru, F., Borggrefe, M., Ghadri, J. R., Akin, I., Templin, C., Galiuto L. (ORCID:0000-0002-6831-479X), and Crea F. (ORCID:0000-0001-9404-8846)

Abstract

BACKGROUND: Atrial fibrillation (AF) is a major risk factor for mortality. The prevalence, clinical correlates, and prognostic impact of AF in Takotsubo syndrome (TTS) have not yet been investigated in a large patient cohort. This study aimed to investigate the prevalence, clinical correlates, and prognostic impact of AF in patients with TTS. METHODS AND RESULTS: Patients with TTS were enrolled from the International Takotsubo Registry, which is a multinational network with 26 participating centers in Europe and the United States. Patients were dichotomized according to the presence or absence of AF at the time of admission. Of 1584 patients with TTS, 112 (7.1%) had AF. The mean age was higher (P<0.001), and there were fewer women (P=0.046) in the AF than in the non-AF group. Left ventricular ejection fraction was significantly lower (P=0.001), and cardiogenic shock was more often observed (P<0.001) in the AF group. Both in-hospital (P<0.001) and long-term mortality (P<0.001) were higher in the AF group. Multivariable Cox regression analysis revealed that AF was independently associated with higher long-term mortality (hazard ratio, 2.31; 95% CI, 1.50– 3.55; P<0.001). Among patients with AF on admission, 42% had no known history of AF before the acute TTS event, and such patients had comparable in-hospital and long-term outcomes compared with those with a history of AF. CONCLUSIONS: In patients presenting with TTS, AF on admission is significantly associated with increased in-hospital and long-term mortality rates. Whether antiarrhythmics and/or cardioversion are beneficial in TTS with AF should thus be tested in a future trial. REGISTRATION: URL: https://www.clini​caltr​ials.gov; Unique identifier: NCT01947621.

Published
2021

28. Prognostic impact of acute pulmonary triggers in patients with takotsubo syndrome: new insights from the International Takotsubo Registry

Author

Kato, K., Cammann, V. L., Napp, L. C., Szawan, K. A., Micek, J., Dreiding, S., Levinson, R. A., Petkova, V., Wurdinger, M., Patrascu, A., Sumalinog, R., Gili, S., Clarenbach, C. F., Kohler, M., Wischnewsky, M., Citro, R., Vecchione, C., Bossone, E., Neuhaus, M., Franke, J., Meder, B., Jaguszewski, M., Noutsias, M., Knorr, M., Heiner, S., D'Ascenzo, Francesca, Dichtl, W., Burgdorf, C., Kherad, B., Tschope, C., Sarcon, A., Shinbane, J., Rajan, L., Michels, G., Pfister, R., Cuneo, A., Jacobshagen, C., Karakas, M., Koenig, W., Pott, A., Meyer, P., Roffi, M., Banning, A., Wolfrum, M., Cuculi, F., Kobza, R., Fischer, T. A., Vasankari, T., Airaksinen, K. E. J., Budnik, M., Dworakowski, R., Maccarthy, P., Kaiser, C., Osswald, S., Galiuto, Leonarda, Chan, C., Bridgman, P., Beug, D., Delmas, C., Lairez, O., Gilyarova, E., Shilova, A., Gilyarov, M., El-Battrawy, I., Akin, I., Kozel, M., Tousek, P., Winchester, D. E., Galuszka, J., Ukena, C., Poglajen, G., Carrilho-Ferreira, P., Hauck, C., Paolini, C., Bilato, C., Sano, M., Ishibashi, I., Takahara, M., Himi, T., Kobayashi, Y., Prasad, A., Rihal, C. S., Liu, K., Schulze, P. C., Bianco, M., Jorg, L., Rickli, H., Pestana, G., Nguyen, T. H., Bohm, M., Maier, L. S., Pinto, F. J., Widimsky, P., Felix, S. B., Opolski, G., Braun-Dullaeus, R. C., Rottbauer, W., Hasenfuss, G., Pieske, B. M., Schunkert, H., Borggrefe, M., Thiele, H., Bauersachs, J., Katus, H. A., Horowitz, J. D., Di Mario, Clara, Munzel, T., Crea, Filippo, Bax, J. J., Luscher, T. F., Ruschitzka, F., Ghadri, J. R., Templin, C., D'Ascenzo F., Galiuto L. (ORCID:0000-0002-6831-479X), Di Mario C., Crea F. (ORCID:0000-0001-9404-8846), Kato, K., Cammann, V. L., Napp, L. C., Szawan, K. A., Micek, J., Dreiding, S., Levinson, R. A., Petkova, V., Wurdinger, M., Patrascu, A., Sumalinog, R., Gili, S., Clarenbach, C. F., Kohler, M., Wischnewsky, M., Citro, R., Vecchione, C., Bossone, E., Neuhaus, M., Franke, J., Meder, B., Jaguszewski, M., Noutsias, M., Knorr, M., Heiner, S., D'Ascenzo, Francesca, Dichtl, W., Burgdorf, C., Kherad, B., Tschope, C., Sarcon, A., Shinbane, J., Rajan, L., Michels, G., Pfister, R., Cuneo, A., Jacobshagen, C., Karakas, M., Koenig, W., Pott, A., Meyer, P., Roffi, M., Banning, A., Wolfrum, M., Cuculi, F., Kobza, R., Fischer, T. A., Vasankari, T., Airaksinen, K. E. J., Budnik, M., Dworakowski, R., Maccarthy, P., Kaiser, C., Osswald, S., Galiuto, Leonarda, Chan, C., Bridgman, P., Beug, D., Delmas, C., Lairez, O., Gilyarova, E., Shilova, A., Gilyarov, M., El-Battrawy, I., Akin, I., Kozel, M., Tousek, P., Winchester, D. E., Galuszka, J., Ukena, C., Poglajen, G., Carrilho-Ferreira, P., Hauck, C., Paolini, C., Bilato, C., Sano, M., Ishibashi, I., Takahara, M., Himi, T., Kobayashi, Y., Prasad, A., Rihal, C. S., Liu, K., Schulze, P. C., Bianco, M., Jorg, L., Rickli, H., Pestana, G., Nguyen, T. H., Bohm, M., Maier, L. S., Pinto, F. J., Widimsky, P., Felix, S. B., Opolski, G., Braun-Dullaeus, R. C., Rottbauer, W., Hasenfuss, G., Pieske, B. M., Schunkert, H., Borggrefe, M., Thiele, H., Bauersachs, J., Katus, H. A., Horowitz, J. D., Di Mario, Clara, Munzel, T., Crea, Filippo, Bax, J. J., Luscher, T. F., Ruschitzka, F., Ghadri, J. R., Templin, C., D'Ascenzo F., Galiuto L. (ORCID:0000-0002-6831-479X), Di Mario C., and Crea F. (ORCID:0000-0001-9404-8846)

Abstract

Aims: Acute pulmonary disorders are known physical triggers of takotsubo syndrome (TTS). This study aimed to investigate prevalence of acute pulmonary triggers in patients with TTS and their impact on outcomes. Methods and results: Patients with TTS were enrolled from the International Takotsubo Registry and screened for triggering factors and comorbidities. Patients were categorized into three groups (acute pulmonary trigger, chronic lung disease, and no lung disease) to compare clinical characteristics and outcomes. Of the 1670 included patients with TTS, 123 (7%) were identified with an acute pulmonary trigger, and 194 (12%) had a known history of chronic lung disease. The incidence of cardiogenic shock was highest in patients with an acute pulmonary trigger compared with those with chronic lung disease or without lung disease (17% vs. 10% vs. 9%, P = 0.017). In-hospital mortality was also higher in patients with an acute pulmonary trigger than in the other two groups, although not significantly (5.7% vs. 1.5% vs. 4.2%, P = 0.13). Survival analysis demonstrated that patients with an acute pulmonary trigger had the worst long-term outcome (P = 0.002). The presence of an acute pulmonary trigger was independently associated with worse long-term mortality (hazard ratio 2.12, 95% confidence interval 1.33–3.38; P = 0.002). Conclusions: The present study demonstrates that TTS is related to acute pulmonary triggers in 7% of all TTS patients, which accounts for 21% of patients with physical triggers. The presence of acute pulmonary trigger is associated with a severe in-hospital course and a worse long-term outcome.

Published
2021

31. Precision medicine: myocardial fibrosis burden and genotype predict outcome in non-ischemic dilated cardiomyopathy (DCM)

Author

Kayvanpour, E, primary, Sedaghat-Hamedani, F, additional, Levinson, R.T, additional, Li, D, additional, Miersch, T, additional, Gi, W.T, additional, Grabe, N, additional, Lahrmann, B, additional, Taeger, T, additional, Frankenstein, L, additional, Uhlmann, L, additional, Herpel, E, additional, Katus, H.A, additional, Saez-Rodriguez, J, additional, and Meder, B, additional

Published
2020
Full Text
View/download PDF

32. Age-Related Variations in Takotsubo Syndrome

Author

Cammann, V. L., Szawan, K. A., Stahli, B. E., Kato, K., Budnik, M., Wischnewsky, M., Dreiding, S., Levinson, R. A., Di Vece, D., Gili, S., Citro, R., Bossone, E., Neuhaus, M., Franke, J., Meder, B., Jaguszewski, M., Noutsias, M., Knorr, M., Heiner, S., D'Ascenzo, F., Dichtl, W., Burgdorf, C., Kherad, B., Tschope, C., Sarcon, A., Shinbane, J., Rajan, L., Michels, G., Pfister, R., Cuneo, A., Jacobshagen, C., Karakas, M., Koenig, W., Pott, A., Meyer, P., Roffi, M., Banning, A., Wolfrum, M., Cuculi, F., Kobza, R., Fischer, T. A., Vasankari, T., Airaksinen, K. E. J., Napp, L. C., Dworakowski, R., Maccarthy, P., Kaiser, C., Osswald, S., Galiuto, Leonarda, Chan, C., Bridgman, P., Beug, D., Delmas, C., Lairez, O., Gilyarova, E., Shilova, A., Gilyarov, M., El-Battrawy, I., Akin, I., Polednikova, K., Tousek, P., Winchester, D. E., Galuszka, J., Ukena, C., Poglajen, G., Carrilho-Ferreira, P., Hauck, C., Paolini, C., Bilato, C., Kobayashi, Y., Shoji, T., Ishibashi, I., Takahara, M., Himi, T., Din, J., Al-Shammari, A., Prasad, A., Rihal, C. S., Liu, K., Schulze, P. C., Bianco, M., Jorg, L., Rickli, H., Pestana, G., Nguyen, T. H., Bohm, M., Maier, L. S., Pinto, F. J., Widimsky, P., Felix, S. B., Braun-Dullaeus, R. C., Rottbauer, W., Hasenfuss, G., Pieske, B. M., Schunkert, H., Borggrefe, M., Thiele, H., Bauersachs, J., Katus, H. A., Horowitz, J. D., Di Mario, C., Munzel, T., Crea, Filippo, Bax, J. J., Luscher, T. F., Ruschitzka, F., Ghadri, J. R., Opolski, G., Templin, C., Galiuto L. (ORCID:0000-0002-6831-479X), Crea F. (ORCID:0000-0001-9404-8846), Cammann, V. L., Szawan, K. A., Stahli, B. E., Kato, K., Budnik, M., Wischnewsky, M., Dreiding, S., Levinson, R. A., Di Vece, D., Gili, S., Citro, R., Bossone, E., Neuhaus, M., Franke, J., Meder, B., Jaguszewski, M., Noutsias, M., Knorr, M., Heiner, S., D'Ascenzo, F., Dichtl, W., Burgdorf, C., Kherad, B., Tschope, C., Sarcon, A., Shinbane, J., Rajan, L., Michels, G., Pfister, R., Cuneo, A., Jacobshagen, C., Karakas, M., Koenig, W., Pott, A., Meyer, P., Roffi, M., Banning, A., Wolfrum, M., Cuculi, F., Kobza, R., Fischer, T. A., Vasankari, T., Airaksinen, K. E. J., Napp, L. C., Dworakowski, R., Maccarthy, P., Kaiser, C., Osswald, S., Galiuto, Leonarda, Chan, C., Bridgman, P., Beug, D., Delmas, C., Lairez, O., Gilyarova, E., Shilova, A., Gilyarov, M., El-Battrawy, I., Akin, I., Polednikova, K., Tousek, P., Winchester, D. E., Galuszka, J., Ukena, C., Poglajen, G., Carrilho-Ferreira, P., Hauck, C., Paolini, C., Bilato, C., Kobayashi, Y., Shoji, T., Ishibashi, I., Takahara, M., Himi, T., Din, J., Al-Shammari, A., Prasad, A., Rihal, C. S., Liu, K., Schulze, P. C., Bianco, M., Jorg, L., Rickli, H., Pestana, G., Nguyen, T. H., Bohm, M., Maier, L. S., Pinto, F. J., Widimsky, P., Felix, S. B., Braun-Dullaeus, R. C., Rottbauer, W., Hasenfuss, G., Pieske, B. M., Schunkert, H., Borggrefe, M., Thiele, H., Bauersachs, J., Katus, H. A., Horowitz, J. D., Di Mario, C., Munzel, T., Crea, Filippo, Bax, J. J., Luscher, T. F., Ruschitzka, F., Ghadri, J. R., Opolski, G., Templin, C., Galiuto L. (ORCID:0000-0002-6831-479X), and Crea F. (ORCID:0000-0001-9404-8846)

Abstract

Background: Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients. Objectives: This study aimed to investigate age-related differences in TTS. Methods: Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: ≤50 years, middle-age: 51 to 74 years, elderly: ≥75 years). Baseline characteristics, hospital course, as well as short- and long-term mortality were compared among groups. Results: Of 2,098 TTS patients, 242 (11.5%) patients were ≤50 years of age, 1,194 (56.9%) were 51 to 74 years of age, and 662 (31.6%) were ≥75 years of age. Younger patients were more often men (12.4% vs. 10.9% vs. 6.3%; p = 0.002) and had an increased prevalence of acute neurological (16.3% vs. 8.4% vs. 8.8%; p = 0.001) or psychiatric disorders (14.1% vs. 10.3% vs. 5.6%; p < 0.001) compared with middle-aged and elderly TTS patients. Furthermore, younger patients had more often cardiogenic shock (15.3% vs. 9.1% vs. 8.1%; p = 0.004) and had a numerically higher in-hospital mortality (6.6% vs. 3.6% vs. 5.1%; p = 0.07). At multivariable analysis, younger (odds ratio: 1.60; 95% confidence interval: 0.86 to 3.01; p = 0.14) and older age (odds ratio: 1.09; 95% confidence interval: 0.66 to 1.80; p = 0.75) were not independently associated with in-hospital mortality using the middle-aged group as a reference. There were no differences in 60-day mortality rates among groups. Conclusions: A substantial proportion of TTS patients are younger than 50 years of age. TTS is associated with severe complications requiring intensive care, particularly in younger patients.

Published
2020

34. Diagnostik und Therapie der kardialen Sarkoidose

Author

Skowasch, D., additional, Gaertner, F., additional, Marx, N., additional, Meder, B., additional, Müller-Quernheim, J., additional, Pfeifer, M., additional, Schrickel, J. W., additional, Yilmaz, A., additional, and Grohé, C., additional

Published
2019
Full Text
View/download PDF

35. Diagnostik und Therapie der kardialen Sarkoidose

Author

Skowasch, D., primary, Gaertner, F., additional, Marx, N., additional, Meder, B., additional, Müller-Quernheim, J., additional, Pfeifer, M., additional, Schrickel, J. W., additional, Yilmaz, A., additional, and Grohé, C., additional

Published
2019
Full Text
View/download PDF

42. Identification and functional characterization of hypoxia-induced endoplasmic reticulum stress regulating lncRNA (HypERlnc) in pericytes

Author

Bischoff, F.C., Werner, A., John, D., Boeckel, J.-N., Melissari, M.-T., Grote, P., Glaser, S.F., Demolli, S., Uchida, S., Michalik, K.M., Meder, B., Katus, H.A., Haas, J., Chen, W., Pullamsetti, S.S., Seeger, W., Zeiher, A.M., Dimmeler, S., and Zehendner, C.M.

Subjects
Cancer Research, Cardiovascular and Metabolic Diseases
Abstract

RATIONALE: Pericytes are essential for vessel maturation and endothelial barrier function. Long noncoding RNAs regulate many cellular functions, but their role in pericyte biology remains unexplored. OBJECTIVE: Here, we investigate the effect of hypoxia-induced endoplasmic reticulum stress regulating long noncoding RNAs (HypERlnc, also known as ENSG00000262454) on pericyte function in vitro and its regulation in human heart failure and idiopathic pulmonary arterial hypertension. METHODS AND RESULTS: RNA sequencing in human primary pericytes identified hypoxia-regulated long noncoding RNAs, including HypERlnc. Silencing of HypERlnc decreased cell viability and proliferation and resulted in pericyte dedifferentiation, which went along with increased endothelial permeability in cocultures consisting of human primary pericyte and human coronary microvascular endothelial cells. Consistently, Cas9-based transcriptional activation of HypERlnc was associated with increased expression of pericyte marker genes. Moreover, HypERlnc knockdown reduced endothelial-pericyte recruitment in Matrigel assays (P

Published
2017

43. P3198Long noncoding RNA NEAT1 controls ROS production in macrophages and is suppressed in post-myocardial infarction patients

Author

Poller, W, primary, Gast, M, additional, Nakagawa, S, additional, Haas, J, additional, Nath, N, additional, Mueller, C, additional, Hirose, T, additional, Rauch, U, additional, Skurk, C, additional, Rauch, B, additional, Blankenberg, S, additional, Kuss, A, additional, Meder, B, additional, Landmesser, U, additional, and Zeller, T, additional

Published
2018
Full Text
View/download PDF

45. 4925Genomic structural variations analysis in dilated cardiomyopathy detects cardiac dysregulation of important RNA species

Author

Haas, J H, primary, Mester, S M, additional, Lai, A L, additional, Frese, K S F, additional, Sedaghat-Hamedani, F S H, additional, Kayvanpour, E K, additional, Boeckel, J N B, additional, Amr, A A, additional, Dietrich, C D, additional, Bordalo, D M B, additional, Korbel, J K, additional, Keller, A K, additional, Katus, H A K, additional, Posch, A P, additional, and Meder, B M, additional

Published
2018
Full Text
View/download PDF

48. Simple trees in complex forests: Growing Take The Best by Approximate Bayesian Computation

Author

Schulz, E., Speekenbrink, M., and Meder, B.

Subjects
FOS: Computer and information sciences, Applications (stat.AP), Statistics - Applications
Abstract

How can heuristic strategies emerge from smaller building blocks? We propose Approximate Bayesian Computation as a computational solution to this problem. As a first proof of concept, we demonstrate how a heuristic decision strategy such as Take The Best (TTB) can be learned from smaller, probabilistically updated building blocks. Based on a self-reinforcing sampling scheme, different building blocks are combined and, over time, tree-like non-compensatory heuristics emerge. This new algorithm, coined Approximately Bayesian Computed Take The Best (ABC-TTB), is able to recover a data set that was generated by TTB, leads to sensible inferences about cue importance and cue directions, can outperform traditional TTB, and allows to trade-off performance and computational effort explicitly.

Published
2016

50. P3381Collagen volume fraction, MMP-2, TIMP-1, GDF-15, and OPN are predictors of adverse outcome in non-ischemic dilated cardiomyopathy

Author

Kayvanpour, E., primary, Sedaghat-Hamedani, F., additional, Li, D.T., additional, Lahrmann, B., additional, Lai, A., additional, Amr, A., additional, Tugrul, O.F., additional, Taeger, T., additional, Herpel, E., additional, Frankenstein, L., additional, Hoefer, I.E., additional, Grabe, N., additional, Stock, C.H., additional, Katus, H.A., additional, and Meder, B., additional

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results