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852 results on '"Mechoulam, R."'

7. Trick or treat from food endocannabinoids?

Author

Di Marzo, V, Sepe, N, De Petrocellis, L, Berger, A, Crozier, G, Fride, E, and Mechoulam, R

Subjects
Milk, Milk, Human, Animals, Humans, Cacao, Ethanolamines, Arachidonic Acids, Glycerides, Endocannabinoids, Food Analysis, Gas Chromatography-Mass Spectrometry, Cannabinoid Receptor Modulators, Human, General Science & Technology
Published
1998

9. Endogenous Cannabinoid Ligands

Author

Mechoulam, R., Shabat, S. Ben, Hanuš, L., Fride, E., Bayewitch, M., Vogel, Z., Friedman, Herman, editor, Eisenstein, Toby K., editor, Madden, John, editor, and Sharp, Burt M., editor

Published
1996
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16. A study investigating the acute dose-response effects of 13 mg and 17 mg D 9tetrahydrocannabinol on cognitive--motor skills, subjective and autonomic measures in regular users of marijuana

Author

Weinstein, A, Brickner, O, Lerman, H, Greemland, M, Bloch, M, Lester, H, Chisin, R, Sarne, Y, Mechoulam, R, Bar-Hamburger, R, Freedman, N, and Even-Sapir, E

Subjects
Motor ability -- Evaluation -- Psychological aspects -- Physiological aspects, Drug addicts -- Drug therapy, Tetrahydrocannabinol -- Dosage and administration -- Physiological aspects, Cognition -- Evaluation -- Physiological aspects -- Psychological aspects, Marijuana -- Physiological aspects -- Psychological aspects -- Dosage and administration -- Evaluation, Pharmaceuticals and cosmetics industries, Psychology and mental health, Drug therapy, Psychological aspects, Evaluation, Physiological aspects, Dosage and administration
Abstract

Keywords: attention; marijuana; maze; motor skills; THC 441 Original papersA study investigating the acute dose-response effects of 13 mg and 17 mg D 9tetrahydrocannabinol on cognitive--motor skills, subjective and autonomic [...]

Published
2008
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37. Peripubertal cannabidiol treatment rescued behavioral and neurochemical abnormalities in MAM model of schizophrenia

Author

Stark T, Ruda-Kucerova J, Iannotti FA, D'Addario C, Di Marco R, Pekarik V, Drazanova E, Piscitelli F, Bari M, Babinska Z, Giurdanella G, Di Bartolomeo M, Salomone S, Sulcova A, Maccarrone M, Wotjak CT, Starcuk Z Jr, Drago F, Mechoulam R, Di Marzo V, and Micale V.

Subjects
mental disorders, Cannabidiol, Cannabinoid CB1 receptor, MAM model, schizophrenia
Abstract

In agreement with the neurodevelopmental hypothesis of schizophrenia, prenatal exposure of rats to the antimitotic agent methylazoxymethanol acetate (MAM) at gestational day 17 produced long-lasting behavioral alterations such as social withdrawal and cognitive impairment in the social interaction test and in the novel object recognition test, respectively. At molecular level, an increased cannabinoid receptor type-1 (CB1) mRNA and protein expression which might be due to a reduction in DNA methylation at gene promoter in the prefrontal cortex (PFC), coincided with deficits in the social interaction test and in the novel object recognition test in MAM rats. Both schizophrenia-like phenotype and altered transcriptional regulation of CB1 receptors were reversed by peripubertal treatment (from PND 19 to PND 39) with the non-psychotropic phytocannabinoid cannabidiol (30 mg/kg/day), or, in part, by treatment with the cannabinoid CB1 receptor antagonist/inverse agonist AM251 (0.5 mg/kg/day), but not with haloperidol (0.6 mg/kg/day). These results suggest that early treatment with cannabidiol may prevent both the appearance of schizophrenia-like deficits as well as CB1 alterations in the PFC at adulthood, supporting that peripubertal cannabidiol treatment might be protective against MAM insult.

Published
2018

43. Recent Advances in the Chemistry of Hashish

Author

Mechoulam, R., Gaoni, Y., Ashurst, P. R., Bohlmann, F., Farkas, L., Gaoni, Y., Kling, H., Mechoulam, R., Morrison, G. A., Pallos, L., Romo, J., De Vivar, A. Romo, Sutherland, J. K., Waldschmidt-Leitz, E., Wieland, Th., and Zechmeister, L., editor

Published
1967
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