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8. Effects of Manidipine and Delapril in Hypertensive Patients With Type 2 Diabetes Mellitus

Author

Ruggenenti, P, Lauria, G, Iliev, IP, Fassi, A, Ilieva, AP, Rota, S, Chiurchiu, C, Barlovic, DP, Sghirlanzoni, A, Lombardi, R, Penza, P, CAVALETTI, GUIDO ANGELO, Piatti, ML, Frigeni, B, Filipponi, M, Rubis, N, Noris, G, Motterlini, N, Ene Iordache, B, Gaspari, F, Perna, A, Zaletel, J, Bossi, A, Dodesini, AR, TREVISAN, ROBERTO, Remuzzi, G, DEMAND Study Investigators, Parvanova, IA, Petrov, II, Yakymchuk, S, Arnoldi, F, Prandini, S, Kocijancic, A, Pongrac, D, Prezelj, J, Gala, T, Kersnik, M, Trevisan, G, Lepore, G, Mondo, E, Inversi, F, Mangili, R, Bruno, S, Brusegan, V, Lecchi, V, Belviso, A, Genovese, S, Pareyson, D, Camozzi, F, Cavaletti, G, Marzorati, L, MARMIROLI, PAOLA LORENA, Mattavelli, L, Tadini, S, Gherardi, G, Calini, W, Diadei, O, Rossoni, D, Villa, D, Carminati, S, Agus, E, Remuzzi, A, Giuliano, GA, Ganeva, M, Cannata, AN, Carrara, F, Cella, C, Centemeri, E, Ferrari, S, Petrò, C, Savoldelli, E, Stucchi, N, Boccardo, P, Perico, N, Peracchi, S, Gelmi, S, Mecca, G, Imbimbo, B, Alberici, M, Gardini, F, Lauria, G., Ruggenenti, P, Lauria, G, Iliev, I, Fassi, A, Ilieva, A, Rota, S, Chiurchiu, C, Barlovic, D, Sghirlanzoni, A, Lombardi, R, Penza, P, Cavaletti, G, Piatti, M, Frigeni, B, Filipponi, M, Rubis, N, Noris, G, Motterlini, N, Ene Iordache, B, Gaspari, F, Perna, A, Zaletel, J, Bossi, A, Dodesini, A, Trevisan, R, Remuzzi, G, DEMAND Study, I, Parvanova, I, Petrov, I, Yakymchuk, S, Arnoldi, F, Prandini, S, Kocijancic, A, Pongrac, D, Prezelj, J, Gala, T, Kersnik, M, Trevisan, G, Lepore, G, Mondo, E, Inversi, F, Mangili, R, Bruno, S, Brusegan, V, Lecchi, V, Belviso, A, Genovese, S, Pareyson, D, Camozzi, F, Marzorati, L, Marmiroli, P, Mattavelli, L, Tadini, S, Gherardi, G, Calini, W, Diadei, O, Rossoni, D, Villa, D, Carminati, S, Agus, E, Remuzzi, A, Giuliano, G, Ganeva, M, Cannata, A, Carrara, F, Cella, C, Centemeri, E, Ferrari, S, Petrò, C, Savoldelli, E, Stucchi, N, Boccardo, P, Perico, N, Peracchi, S, Gelmi, S, Mecca, G, Imbimbo, B, Alberici, M, and Gardini, F

Subjects
Adult, Blood Glucose, Male, Dihydropyridines, medicine.medical_specialty, Diabetic neuropathy, Urology, Renal function, Delapril, Angiotensin-Converting Enzyme Inhibitors, Kidney Function Tests, Placebo, Risk Assessment, Severity of Illness Index, Drug Administration Schedule, Piperazines, Body Mass Index, Manidipine, Double-Blind Method, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Diabetic Nephropathies, Nitrobenzenes, Aged, Dose-Response Relationship, Drug, diabetes, business.industry, Hazard ratio, Middle Aged, Calcium Channel Blockers, Prognosis, medicine.disease, Survival Rate, Treatment Outcome, Endocrinology, Diabetes Mellitus, Type 2, Hypertension, Indans, Albuminuria, Drug Therapy, Combination, Female, medicine.symptom, business, medicine.drug
Abstract

To assess whether angiotensin-converting enzyme inhibitors and third-generation dihydropyridine calcium channel blockers ameliorate diabetic complications, we compared glomerular filtration rate (GFR; primary outcome), cardiovascular events, retinopathy, and neuropathy in 380 hypertensive type 2 diabetics with albuminuria 2 (IQR: 0.16–0.50 mL/min per 1.73 m 2 ) on combined therapy, 0.36 mL/min per 1.73 m 2 (IQR: 0.18–0.53 mL/min per 1.73 m 2 ) on delapril, and 0.30 mL/min per 1.73 m 2 (IQR: 0.12–0.50 mL/min per 1.73 m 2 ) on placebo ( P =0.87 and P =0.53 versus combined therapy or delapril, respectively). Similar findings were observed when baseline GFR values were not considered for slope analyses. Albuminuria was stable in the 3 treatment groups. The hazard ratio (95% CI) for major cardiovascular events between combined therapy and placebo was 0.17 (0.04–0.78; P =0.023). Among 192 subjects without retinopathy at inclusion, the hazard ratio for developing retinopathy between combined therapy and placebo was 0.27 (0.07–0.99; P =0.048). Among 200 subjects with centralized neurological evaluation, the odds ratios for peripheral neuropathy at 3 years between combined therapy or delapril and placebo were 0.45 (0.24–0.87; P =0.017) and 0.52 (0.27–0.99; P =0.048), respectively. Glucose disposal rate decreased from 5.8±2.4 to 5.3±1.9 mg/kg per min on placebo ( P =0.03) but did not change on combined or delapril therapy. Treatment was well tolerated. In hypertensive type 2 diabetic patients, combined manidipine and delapril therapy failed to slow GFR decline but safely ameliorated cardiovascular disease, retinopathy, and neuropathy and stabilized insulin sensitivity.

Published
2011

24. Exposing open street map in the linked data cloud

Author

Bochicchio, MA, Mecca, G, Anelli, V, Cali, A, Di Noia, T, Maurino, A, Palmonari, M, Ragone, A, Anelli V. W., Cali A., Di Noia T., Maurino A., Palmonari M., Ragone A., Bochicchio, MA, Mecca, G, Anelli, V, Cali, A, Di Noia, T, Maurino, A, Palmonari, M, Ragone, A, Anelli V. W., Cali A., Di Noia T., Maurino A., Palmonari M., and Ragone A.

Abstract

Nowadays, the pervasive and mobile nature of information paves the way to a new family of location-aware services and tools. Geographical data are gaining momentum and this reflects in the growing of dedicated datasets in the Linked Data (LD) cloud. The very last version of the LD cloud diagram shows Geonames competing with DBpedia not just in terms of amount of data but also with reference to the number of links coming from/going to other datasets. Among the different Web projects, one the most important players in the geoarena, is for sure Open Street Map (OSM). It exposes a huge amount of data which is continually updated in a crowdsourced fashion. In order to make all this knowledge available as Linked Data, we developed LOSM: a SPARQL endpoint able to query the data available in OSM by an on-line translation form SPARQL syntax to a sequence of calls to the OSM overpass API.

Published
2016

46. Araneus in the Era of XML

Author

MECCA G., MERIALDO, PAOLO, ATZENI, Paolo, Mecca, G., Merialdo, Paolo, and Atzeni, Paolo

Published
1999

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