Search

Your search keyword '"Mecarelli, Oriano"' showing total 467 results
Start Over Author "Mecarelli, Oriano"
467 results on '"Mecarelli, Oriano"'

4. Brivaracetam as Early Add-On Treatment in Patients with Focal Seizures: A Retrospective, Multicenter, Real-World Study

Author

Lattanzi, Simona, Canafoglia, Laura, Canevini, Maria Paola, Casciato, Sara, Cerulli Irelli, Emanuele, Chiesa, Valentina, Dainese, Filippo, De Maria, Giovanni, Didato, Giuseppe, Di Gennaro, Giancarlo, Falcicchio, Giovanni, Fanella, Martina, Ferlazzo, Edoardo, Gangitano, Massimo, La Neve, Angela, Mecarelli, Oriano, Montalenti, Elisa, Morano, Alessandra, Piazza, Federico, Pizzanelli, Chiara, Pulitano, Patrizia, Ranzato, Federica, Rosati, Eleonora, Tassi, Laura, and Di Bonaventura, Carlo

Published
2022
Full Text
View/download PDF

6. Do changes in SSEP amplitude over time predict the outcome of comatose survivors of cardiac arrest?

Author

Scarpino, Maenia, Lolli, Francesco, Lanzo, Giovanni, Carrai, Riccardo, Spalletti, Maddalena, Valzania, Franco, Lombardi, Maria, Audenino, Daniela, Contardi, Sara, Grazia Celani, Maria, Marrelli, Alfonso, Mecarelli, Oriano, Minardi, Chiara, Minicucci, Fabio, Politini, Lucia, Vitelli, Eugenio, Peris, Adriano, Amantini, Aldo, Grippo, Antonello, and Sandroni, Claudio

Published
2022
Full Text
View/download PDF

8. Adjunctive Brivaracetam in Older Patients with Focal Seizures: Evidence from the BRIVAracetam add‑on First Italian netwoRk Study (BRIVAFIRST)

Author

Lattanzi, Simona, Canafoglia, Laura, Canevini, Maria Paola, Casciato, Sara, Cerulli Irelli, Emanuele, Chiesa, Valentina, Dainese, Filippo, De Maria, Giovanni, Didato, Giuseppe, Falcicchio, Giovanni, Fanella, Martina, Ferlazzo, Edoardo, Gangitano, Massimo, Giorgi, Filippo Sean, La Neve, Angela, Mecarelli, Oriano, Montalenti, Elisa, Morano, Alessandra, Piazza, Federico, Pulitano, Patrizia, Quarato, Pier Paolo, Ranzato, Federica, Rosati, Eleonora, Tassi, Laura, and Di Bonaventura, Carlo

Published
2022
Full Text
View/download PDF

9. Motor and Nonmotor Epileptic Seizures

Author

Minicucci, Fabio, Aguglia, Umberto, de Falco, Fabrizio Antonio, Mecarelli, Oriano, Michelucci, Roberto, Tinuper, Paolo, Micieli, Giuseppe, editor, Cavallini, Anna, editor, Ricci, Stefano, editor, Consoli, Domenico, editor, and Edlow, Jonathan A., editor

Published
2021
Full Text
View/download PDF

10. Traduzione e adattamento alla lingua italiana del glossario dei termini più comunemente usati dagli elettroencefalografisti clinici e proposta per il formato del referto EEG (Revisione IFCN 2017)

Author

Alvisi, Lara, Cantalupo, Gaetano, Eleopra, Roberto, Guerra, Angelo, Lori, Silvia, Marinelli, Lucio, Tassi, Laura, Tinuper, Paolo, Vigevano, Federico, Strigaro, Gionata, Bisulli, Francesca, Assenza, Giovanni, Mecarelli, Oriano, Grippo, Antonello, and Meletti, Stefano

Published
2022
Full Text
View/download PDF

11. Adjunctive Brivaracetam in Focal Epilepsy: Real-World Evidence from the BRIVAracetam add-on First Italian netwoRk STudy (BRIVAFIRST)

Author

Lattanzi, Simona, Canafoglia, Laura, Canevini, Maria Paola, Casciato, Sara, Chiesa, Valentina, Dainese, Filippo, De Maria, Giovanni, Didato, Giuseppe, Falcicchio, Giovanni, Fanella, Martina, Ferlazzo, Edoardo, Fisco, Giacomo, Gangitano, Massimo, Giallonardo, Anna Teresa, Giorgi, Filippo Sean, La Neve, Angela, Mecarelli, Oriano, Montalenti, Elisa, Piazza, Federico, Pulitano, Patrizia, Quarato, Pier Paolo, Ranzato, Federica, Rosati, Eleonora, Tassi, Laura, and Di Bonaventura, Carlo

Published
2021
Full Text
View/download PDF

12. Defining the phenotypic spectrum of SLC6A1 mutations

Author

Johannesen, Katrine M, Gardella, Elena, Linnankivi, Tarja, Courage, Carolina, Martin, Anne Saint, Lehesjoki, Anna‐Elina, Mignot, Cyril, Afenjar, Alexandra, Lesca, Gaetan, Abi‐Warde, Marie‐Thérèse, Chelly, Jamel, Piton, Amélie, Merritt, J Lawrence, Rodan, Lance H, Tan, Wen‐Hann, Bird, Lynne M, Nespeca, Mark, Gleeson, Joseph G, Yoo, Yongjin, Choi, Murim, Chae, Jong‐Hee, Czapansky‐Beilman, Desiree, Reichert, Sara Chadwick, Pendziwiat, Manuela, Verhoeven, Judith S, Schelhaas, Helenius J, Devinsky, Orrin, Christensen, Jakob, Specchio, Nicola, Trivisano, Marina, Weber, Yvonne G, Nava, Caroline, Keren, Boris, Doummar, Diane, Schaefer, Elise, Hopkins, Sarah, Dubbs, Holly, Shaw, Jessica E, Pisani, Laura, Myers, Candace T, Tang, Sha, Tang, Shan, Pal, Deb K, Millichap, John J, Carvill, Gemma L, Helbig, Kathrine L, Mecarelli, Oriano, Striano, Pasquale, Helbig, Ingo, Rubboli, Guido, Mefford, Heather C, and Møller, Rikke S

Subjects
Behavioral and Social Science, Neurodegenerative, Neurosciences, Genetics, Epilepsy, Clinical Research, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Neurological, Adolescent, Adult, Anticonvulsants, Ataxia, Child, Child, Preschool, Cohort Studies, Electroencephalography, Epilepsies, Myoclonic, Epilepsies, Partial, Epilepsy, Generalized, Female, GABA Plasma Membrane Transport Proteins, Genetic Association Studies, Humans, Intellectual Disability, Language Development Disorders, Male, Mutation, Mutation, Missense, Neurodevelopmental Disorders, Phenotype, Treatment Outcome, Valproic Acid, Young Adult, epilepsy, epilepsy genetics, MAE, SLC6A1, MAE, SLC6A1, Clinical Sciences, Neurology & Neurosurgery
Abstract

ObjectivePathogenic SLC6A1 variants were recently described in patients with myoclonic atonic epilepsy (MAE) and intellectual disability (ID). We set out to define the phenotypic spectrum in a larger cohort of SCL6A1-mutated patients.MethodsWe collected 24 SLC6A1 probands and 6 affected family members. Four previously published cases were included for further electroclinical description. In total, we reviewed the electroclinical data of 34 subjects.ResultsCognitive development was impaired in 33/34 (97%) subjects; 28/34 had mild to moderate ID, with language impairment being the most common feature. Epilepsy was diagnosed in 31/34 cases with mean onset at 3.7 years. Cognitive assessment before epilepsy onset was available in 24/31 subjects and was normal in 25% (6/24), and consistent with mild ID in 46% (11/24) or moderate ID in 17% (4/24). Two patients had speech delay only, and 1 had severe ID. After epilepsy onset, cognition deteriorated in 46% (11/24) of cases. The most common seizure types were absence, myoclonic, and atonic seizures. Sixteen cases fulfilled the diagnostic criteria for MAE. Seven further patients had different forms of generalized epilepsy and 2 had focal epilepsy. Twenty of 31 patients became seizure-free, with valproic acid being the most effective drug. There was no clear-cut correlation between seizure control and cognitive outcome. Electroencephalography (EEG) findings were available in 27/31 patients showing irregular bursts of diffuse 2.5-3.5 Hz spikes/polyspikes-and-slow waves in 25/31. Two patients developed an EEG pattern resembling electrical status epilepticus during sleep. Ataxia was observed in 7/34 cases. We describe 7 truncating and 18 missense variants, including 4 recurrent variants (Gly232Val, Ala288Val, Val342Met, and Gly362Arg).SignificanceMost patients carrying pathogenic SLC6A1 variants have an MAE phenotype with language delay and mild/moderate ID before epilepsy onset. However, ID alone or associated with focal epilepsy can also be observed.

Published
2018

19. Migraine

Author

Davassi, Chiara, Pulitano, Patrizia, Mecarelli, Oriano, and Mecarelli, Oriano, editor

Published
2019
Full Text
View/download PDF

26. Artifacts

Author

Brienza, Marianna, Davassi, Chiara, Mecarelli, Oriano, and Mecarelli, Oriano, editor

Published
2019
Full Text
View/download PDF

34. Ambulatory EEG

Author

Brienza, Marianna, Davassi, Chiara, Mecarelli, Oriano, and Mecarelli, Oriano, editor

Published
2019
Full Text
View/download PDF

37. The management of epilepsy in clinical practice: Do the timing and severity of the disease influence the priorities of patients and the caring physicians? Data from the EPINEEDS study

Author

Pulitano, Patrizia, Cagnetti, Claudia, Baldinelli, Sara, La Neve, Angela, Tappatà, Maria, Francavilla, Teresa, De Maria, Giovanni, Sofia, Vito, Giuliano, Loretta, Mainieri, Greta, Fatuzzo, Daniela, Belcastro, Vincenzo, Elia, Maurizio, D'Orsi, Giuseppe, Lalla, Alessandra, Salmaggi, Andrea, Brigo, Francesco, Magaudda, Adriana, Pisani, Francesco, Galletta, Santi, Pisani, Laura R., Raffaele, Massimo, Cosenza, Domenico, Villani, Flavio S., Quintas, Rui M.M., Cervellione, Rosa, Borroni, Simona, Meletti, Stefano, Ferrarese, Carlo, Barbella, Giuseppina, Di Francesco, Jacopo, Bogliun, Graziella, Beretta, Simone, Galimberti, Carlo A., Cantisani, Teresa A., Cecconi, Michela, Celani, Maria G., Papetti, Rossella, Giorgi, Filippo S., Aguglia, Umberto, Gasparini, Sara, Ferlazzo, Edoardo, Manganotti, Paolo, Crichiutti, Giovanni, Bravar, Giulia, Enia, Gabriele, Giussani, Giorgia, Bianchi, Elisa, Mecarelli, Oriano, and Beghi, Ettore

Published
2021
Full Text
View/download PDF

39. Models of care and relevance of territorial management in assisting persons with epilepsy

Author

Mecarelli, Oriano and Mecarelli, Oriano

Abstract

Epilepsy is a widespread social disease that affects people of all ages and often involves both diagnostic and therapeutic difficulties. Beyond seizure control, it is necessary to ensure people with epilepsy a good quality of life and respect for human rights, seeking to increase self-management capacity and break down stigma. People with epilepsy should have privileged access to specialized epilepsy centers, where multidisciplinary care is possible. These centers, organized by different levels of complexity, should be uniformly distributed throughout the country and networked together. The scientific community and health care organizations must therefore design all necessary strategies so that knowledge about epilepsy improves among the general population and the most effective pathways of care are effectively implemented.

Published
2024

40. Correction to: Adjunctive Brivaracetam in Focal Epilepsy: Real‑World Evidence from the BRIVAracetam add‑on First Italian netwoRk Study (BRIVAFIRST)

Author

Lattanzi, Simona, Canafoglia, Laura, Canevini, Maria Paola, Casciato, Sara, Chiesa, Valentina, Dainese, Filippo, De Maria, Giovanni, Didato, Giuseppe, Falcicchio, Giovanni, Fanella, Martina, Ferlazzo, Edoardo, Fisco, Giacomo, Gangitano, Massimo, Giallonardo, Anna Teresa, Giorgi, Filippo Sean, La Neve, Angela, Mecarelli, Oriano, Montalenti, Elisa, Piazza, Federico, Pulitano, Patrizia, Quarato, Pier Paolo, Ranzato, Federica, Rosati, Eleonora, Tassi, Laura, and Di Bonaventura, Carlo

Published
2021
Full Text
View/download PDF

43. Targeted re-sequencing in malformations of cortical development: genotype-phenotype correlations

Author

Accogli, Andrea, Severino, Mariasavina, Riva, Antonella, Madia, Francesca, Balagura, Ganna, Iacomino, Michele, Carlini, Barbara, Baldassari, Simona, Giacomini, Thea, Croci, Carolina, Pisciotta, Livia, Messana, Tullio, Boni, Antonella, Russo, Angelo, Bilo, Leonilda, Tonziello, Rosa, Coppola, Antonietta, Filla, Alessandro, Mecarelli, Oriano, Casalone, Rosario, Pisani, Francesco, Falsaperla, Raffaele, Marino, Silvia, Parisi, Pasquale, Ferretti, Alessandro, Elia, Maurizio, Luchetti, Anna, Milani, Donatella, Vanadia, Francesca, Silvestri, Laura, Rebessi, Erika, Parente, Eliana, Vatti, Giampaolo, Mancardi, Maria Margherita, Nobili, Lino, Capra, Valeria, Salpietro, Vincenzo, Striano, Pasquale, and Zara, Federico

Published
2020
Full Text
View/download PDF

45. Use, experience and perspectives of high-density EEG among Italian epilepsy centers: a national survey

Author

Nucera, Bruna, primary, Perulli, Marco, additional, Alvisi, Lara, additional, Bisulli, Francesca, additional, Bonanni, Paolo, additional, Canafoglia, Laura, additional, Cantalupo, Gaetano, additional, Ferlazzo, Edoardo, additional, Granvillano, Alice, additional, Mecarelli, Oriano, additional, Meletti, Stefano, additional, Strigaro, Gionata, additional, Tartara, Elena, additional, and Assenza, Giovanni, additional

Published
2023
Full Text
View/download PDF

46. Motor and Nonmotor Epileptic Seizures

Author

Minicucci, Fabio, primary, Aguglia, Umberto, additional, de Falco, Fabrizio Antonio, additional, Mecarelli, Oriano, additional, Michelucci, Roberto, additional, and Tinuper, Paolo, additional

Published
2020
Full Text
View/download PDF

49. N°307 – Validation of a machine learning algorithm for the prediction of first anti-seizure medication response in focal epilepsy: A multicenter cross-sectional study

Author

Ricci, Lorenzo, primary, Croce, Pierpaolo, additional, Zappasodi, Filippo, additional, di Lazzaro, Vincenzo, additional, Ferreri, Florinda, additional, Sensi, Stefano L., additional, Dono, Fedele, additional, Nucera, Bruna, additional, Brigo, Francesco, additional, Izzi, Francesca, additional, Placidi, Fabio, additional, Pulitano, Patrizia, additional, Mecarelli, Oriano, additional, Tombini, Mario, additional, and Assenza, Giovanni, additional

Published
2023
Full Text
View/download PDF

50. Adjunctive brivaracetam and sustained seizure frequency reduction in very active focal epilepsy.

Author

Lattanzi, Simona, Canafoglia, Laura, Canevini, Maria Paola, Casciato, Sara, Cerulli Irelli, Emanuele, Chiesa, Valentina, Dainese, Filippo, De Maria, Giovanni, Didato, Giuseppe, Di Gennaro, Giancarlo, Falcicchio, Giovanni, Fanella, Martina, Ferlazzo, Edoardo, Gangitano, Massimo, La Neve, Angela, Mecarelli, Oriano, Montalenti, Elisa, Morano, Alessandra, Piazza, Federico, and Pizzanelli, Chiara

Subjects
PARTIAL epilepsy, SEIZURES (Medicine), TERMINATION of treatment
Abstract

Objective: This study aimed to explore the effectiveness of brivaracetam (BRV) according to baseline seizure frequency and past treatment history in subjects with focal epilepsy who were included in the Brivaracetam Add‐On First Italian Network Study (BRIVAFIRST). Methods: BRIVAFIRST was a 12‐month retrospective, multicenter study including adults prescribed adjunctive BRV. Study outcomes included sustained seizure response (SSR), sustained seizure freedom (SSF), and the rates of treatment discontinuation and adverse events (AEs). Baseline seizure frequency was stratified as <5, 5–20, and >20 seizures per month, and the number of prior antiseizure medications (ASMs) as <5 and ≥6. Results: A total of 994 participants were included. During the 1‐year study period, SSR was reached by 45.8%, 39.3%, and 22.6% of subjects with a baseline frequency of <5, 5–20, and >20 seizures per month (p <.001); the corresponding figures for the SSF were 23.4%, 9.8%, and 2.8% (p <.001). SSR was reached by 51.2% and 26.5% participants with a history of 1–5 and ≥6 ASMs (p <.001); the corresponding rates of SSF were 24.7% and 4.5% (p <.001). Treatment discontinuation due to lack of efficacy was more common in participants with >20 seizures compared to those with <5 seizures per month (25.8% vs. 9.3%, p <.001), and in participants with history of ≥6 prior ASMs compared to those with history of 1–5 ASMs (19.6% vs. 12.2%, p =.002). There were no differences in the rates of BRV withdrawal due to AEs and the rates of AEs across the groups of participants defined according to the number of seizures at baseline and the number of prior ASMs. Significance: The baseline seizure frequency and the number of previous ASMs were predictors of sustained seizure frequency reduction with adjunctive BRV in subjects with focal epilepsy. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results