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This article considers two nontraditional approaches for developing interventions to improve cognition in older adults. Neither of these approaches relies on traditional explicit training of specific abilities in the laboratory. The first technique involves the activation of automatic processes through the formation of implementation intentions that enhance the probability that a desired action will be completed, such as remembering to take medications. The second involves experimentally studying the role of active social and cognitive engagement in improving cognition. We then consider methodological issues associated with the use of these novel techniques. [ABSTRACT FROM AUTHOR]

Collaboration plays an important role in educational contexts. However, little is known about students' metacognitive beliefs about collaboration. The present study used an online survey to investigate students' beliefs toward group study/recall, their studying preferences, strategies they use when studying individually and in groups, and important characteristics of their group members. Results indicate that, although students generally perceive collaboration as beneficial, they prefer individual study, indicating that their beliefs are inconsistent with their learning preferences. Students report social learning as the primary reason for collaborative benefits but prefer to study alone to minimize distraction and increase personal accountability. Further, they use different strategies when studying individually or in a group. When studying individually, students most frequently report re-reading their notes. However, when studying in groups, students most frequently use strategies emphasizing collaboration and interaction, such as quizzing each other. Also, students prefer to work with group members who are focused, motivated, and hard working. Students' beliefs, preferences, and favored characteristics of group members are related to their frequency of using study groups. Students' metacognitive beliefs about collaboration have implications for theories of self-regulated learning and better use of collaboration in educational contexts.

In the current study, we investigated how long the effects of one single collaboration session continue to influence individual memory. Participants learned categorized word lists and prose passages individually, and then they were instructed to recall learned materials either collaboratively or individually. Following initial recall, participants completed an individual recall test after a delay of 5 min, 48 h, or 1 week. On the initial recall test, we found that collaboration reduced recall of correct items on both word lists and prose passages (collaborative inhibition), and that collaboration reduced false recall on both word lists and prose passages (error correction). However, on the subsequent individual memory test after a delay, the pattern of post collaborative effects differed across veridical and false recall. For both word lists and prose passages, post collaborative benefits on correct recall lasted 1 week. However, there were no lasting effects of error correction on subsequent false recall. These results suggest that the time course of post collaborative benefits can be long lasting, but they are selective to veridical recall. The results are explained by theories of reexposure and error correction., (© 2024. The Author(s).)

Collaborative inhibition (reduced recall in collaborative vs. nominal groups) is a robust phenomenon. However, it is possible that not everyone is as susceptible to collaborative inhibition, such as those higher in working memory capacity (WMC). In the current study, we examined the relationship between WMC and collaborative inhibition. Participants completed three shortened span tasks (automated operation span, automated reading span, symmetry span). They then viewed categorized word lists individually and then recalled the word lists alone or with a partner (Test 1), followed by an individual recall (Test 2). For correct recall, collaborative inhibition was greater among lower WMC individuals, and they showed no post collaborative benefits. Only higher WMC individuals benefited from prior collaboration. For false recall, higher WMC individuals had less false recall on Tests 1 and 2, and collaboration reduced errors on Test 1 for both lower- and higher WMC individuals. There were no lasting effects of collaboration on Test 2 errors. Furthermore, partner WMC appeared to influence recall, although this tentative finding is based on a smaller sample size. Specifically, on Test 2, participants had less false recall when their partner was higher in WMC and greater correct recall when both they and their partner were higher in WMC. We conclude that collaboration is relatively more harmful for lower WMC individuals and more beneficial for higher WMC individuals. These results inform theories of collaborative inhibition by identifying attentional control and WMC as mechanisms that moderate the magnitude of the effect. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Two experiments examined the role of spontaneous relative judgments within the social contagion of memory paradigm (Roediger, Meade, & Bergman, 2001). Participants viewed household scenes (for short or long durations) in collaboration with a confederate (with low, average, or superior memory ability) who falsely recalled incorrect items as having occurred in the scenes. Of interest was whether or not participants would spontaneously evaluate the state of their own memory relative to the state of the confederate's memory when remembering suggested information. Participant responses on a metacognitive questionnaire demonstrated that participants were aware of their own memory ability relative to the memory ability of their partner. Interestingly, this information influenced participants' remember responses on the recall test only when they felt their own memory was relatively poor. Participants make self-initiated, relative judgments of memory when working with others on a memory test, and these judgments are driven by metacognitive differences in remember responses. The results highlight the importance of metacognition in understanding relative judgments in social memory., (Copyright © 2020. Published by Elsevier B.V.)

This study examined the influence of same-age and mixed-age dyads on the collaborative inhibition effect (reduced recall in collaborative groups compared to the combined recall of the same number people who recall individually). Younger (age 18-25) and older (age 65+) adults recalled categorized word lists alone or in collaboration with a same-age or a different-age partner. On an initial recall test, the magnitude of collaborative inhibition for veridical recall was similar across dyads, regardless of age. However, age differences emerged in false recall as older adults were less likely to correct each other's errors than younger adults in same-age dyads. Older adults in same-age dyads continued to demonstrate greater false recall on a subsequent recall test, but there were no lasting costs of collaboration on subsequent recall or recognition for same-age or mixed-age dyads. Mixed-age dyads were more likely to provide a simple acknowledgment and less likely to remain silent in response to partner suggestions than were same-age partners, however, this did not affect the magnitude of collaborative inhibition. Any lasting effects of collaboration are invariant across same-age and mixed-age partners. The results demonstrate age-invariance of the retrieval strategy disruption theory and highlight collaborative process variables as complementary mechanisms of collaborative inhibition. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

These experiments are the first to investigate the impact of confederate accuracy, age, and age stereotypes in the social contagion of memory paradigm. Across two experiments, younger participants recalled household scenes with an actual (Experiment 1) or virtual (Experiment 2), older or younger confederate who suggested different proportions (0%, 33% or 100%) of false items during collaboration. In Experiment 2, positive and negative age stereotypes were primed by providing bogus background information about our older confederate before collaboration. Across both experiments, if confederates suggested false items participants readily incorporated these into their own memory reports. In Experiment 1, when no age stereotype was primed, participants adopted similar proportions of false items from younger and older confederates. Importantly, in Experiment 2, when our older confederate was presented in terms of negative ageing stereotypes, participants reported less false items and were better able to correctly identify the source of those false items.

Acute exposure to high concentrations of H 2 S causes severe brain injury and long-term neurological disorders, but the mechanisms involved are not known. To better understand the cellular and molecular mechanisms involved in acute H 2 S-induced neurodegeneration we used a broad-spectrum proteomic analysis approach to identify key molecules and molecular pathways involved in the pathogenesis of acute H 2 S-induced neurotoxicity and neurodegeneration. Mice were subjected to acute inhalation exposure of up to750 ppm of H 2 S. H 2 S induced behavioral deficits and severe lesions including hemorrhage in the inferior colliculus (IC). The IC was microdissected for proteomic analysis. Tandem mass tags (TMT) liquid chromatography mass spectrometry (LC-MS/MS)-based quantitative proteomics was applied for protein identification and quantitation. LC-MS/MS identified 598, 562, and 546 altered proteomic changes at 2 h, and on days 2 and 4 post-H 2 S exposure, respectively. Of these, 77 proteomic changes were statistically significant at any of the 3 time points. Mass spectrometry data were subjected to Perseus 1.5.5.3 statistical analysis, and gene ontology heat map clustering. Expressions of several key molecules were verified to confirm H 2 S-dependent proteomics changes. Webgestalt pathway overrepresentation enrichment analysis with Panther engine revealed H 2 S exposure disrupted several biological processes including metabotropic glutamate receptor group 1 and inflammation mediated by chemokine and cytokine signaling pathways among others. Further analysis showed that energy metabolism, integrity of blood-brain barrier, hypoxic, and oxidative stress signaling pathways were also implicated. Collectively, this broad-spectrum proteomics data has provided important clues to follow up in future studies to further elucidate mechanisms of H 2 S-induced neurotoxicity., (Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.)

This project investigated the underlying mechanisms that boost false remember responses when participants receive study words that are both semantically and phonologically similar to a critical lure. Participants completed a memory task in which they were presented with a list of words all associated with a critical lure. Included within the list of semantic associates was a target that was either semantically associated (e.g., yawn) to the critical lure (e.g., sleep) or shared the initial (e.g., slam) or final (e.g., beep) phoneme(s) with the critical lure. After hearing the list, participants recalled each list item and indicated whether they just knew it was on the list or if they instead recollected specific contextual details of that item's presentation. We found that inserting an initial phonemic overlap target boosted experiences of recollection, but only when semantically related associates were presented beforehand. The results are consistent with models of spoken word recognition and show that established semantic context plus initial phonemic overlap play important roles in boosting false recollection.

Three experiments examined the impact of partner age on the magnitude of socially suggested false memories. Young participants recalled household scenes in collaboration with an implied young or older adult partner who intentionally recalled false items. In Experiment 1, participants were presented with only the age of their partner (low age-salience context); in Experiment 2, participants were presented with the age of their partner along with a photograph and biographical information about their partner (high age-salience context); in Experiment 3, age salience was varied within the same experiment. Across experiments, participants in both the low age-salience and high age-salience contexts incorporated their partners' misleading suggestions into their own subsequent recall and recognition reports, thus demonstrating social contagion with implied partners. Importantly, the effect of partner age differed across conditions. Participants in the high age-salience context were less likely to incorporate misleading suggestions from older adult partners than from young adult partners, but participants in the low age-salience context were equally likely to incorporate suggestions from young and older adult partners. Participants discount the memory of older adult partners only when age is highly salient.

The brainstem represents a major tissue area affected by sarin organophosphate poisoning due to its function in respiratory and cardiovascular control. While the acute toxic effects of sarin on brainstem-related responses are relatively unknown, other brain areas e.g., cortex or cerebellum, have been studied more extensively. The study objective was to analyze the guinea pig brainstem toxicology response following sarin (2×LD50) exposure by proteome pathway analysis to gain insight into the complex regulatory mechanisms that lead to impairment of respiratory and cardiovascular control. Guinea pig exposure to sarin resulted in the typical acute behavior/physiology outcomes with death between 15 and 25min. In addition, brain and blood acetylcholinesterase activity was significantly reduced in the presence of sarin to 95%, and 89%, respectively, of control values. Isobaric-tagged (iTRAQ) liquid chromatography tandem mass spectrometry (LC-MS/MS) identified 198 total proteins of which 23% were upregulated, and 18% were downregulated following sarin exposure. Direct gene ontology (GO) analysis revealed a sarin-specific broad-spectrum proteomic profile including glutamate-mediated excitotoxicity, calcium overload, energy depletion responses, and compensatory carbohydrate metabolism, increases in ROS defense, DNA damage and chromatin remodeling, HSP response, targeted protein degradation (ubiquitination) and cell death response. With regards to the sarin-dependent effect on respiration, our study supports the potential interference of sarin with CO2/H(+) sensitive chemoreceptor neurons of the brainstem retrotrapezoid nucleus (RTN) that send excitatory glutamergic projections to the respiratory centers. In conclusion, this study gives insight into the brainstem broad-spectrum proteome following acute sarin exposure and the gained information will assist in the development of novel countermeasures., (Published by Elsevier B.V.)

In this study, we examined whether increasing the proportion of false information suggested by a confederate would influence the magnitude of socially introduced false memories in the social contagion paradigm Roediger, Meade, & Bergman (Psychonomic Bulletin & Review 8:365-371, 2001). One participant and one confederate collaboratively recalled items from previously studied household scenes. During collaboration, the confederate interjected 0 %, 33 %, 66 %, or 100 % false items. On subsequent individual-recall tests across three experiments, participants were just as likely to incorporate misleading suggestions from a partner who was mostly accurate (33 % incorrect) as they were from a partner who was not at all accurate (100 % incorrect). Even when participants witnessed firsthand that their partner had a very poor memory on a related memory task, they were still as likely to incorporate the confederate's entirely misleading suggestions on subsequent recall and recognition tests (Exp. 2). Only when participants witnessed firsthand that their partner had a very poor memory on a practice test of the experimental task itself were they able to reduce false memory, and this reduction occurred selectively on a subsequent individual recognition test (Exp. 3). These data demonstrate that participants do not always consider their partners' memory ability when working on collaborative memory tasks.

In three experiments, participants studied photographs of common household scenes. Following study, participants completed a category-cued recall test without feedback (Exps. 1 and 3), a category-cued recall test with feedback (Exp. 2), or a filler task (no-test condition). Participants then viewed recall tests from fictitious previous participants that contained erroneous items presented either one or four times, and then completed final recall and source recognition tests. The participants in all conditions reported incorrect items during final testing (a social contagion effect), and across experiments, initial testing had no impact on false recall of erroneous items. However, on the final source-monitoring recognition test, initial testing had a protective effect against false source recognition: Participants who were initially tested with and without feedback on category-cued initial tests attributed fewer incorrect items to the original event on the final source-monitoring recognition test than did participants who were not initially tested. These data demonstrate that initial testing may protect individuals' memories from erroneous suggestions.

In the present study, we examined the impacts of participant age and confederate age on social memory processes. During a collaborative recall phase, young and older adult participants were exposed to the erroneous memory reports of a young or an older adult confederate. On a subsequent individual recall test, young and older adult participants were equally likely to incorporate the confederates' erroneous suggestions into their memory reports, suggesting that participant age had a minimal effect on social memory processes. However, confederate age did have a marked effect: Young adult participants were less likely to incorporate misleading suggestions from older adult confederates and less likely to report "remembering" items suggested by older adult confederates. Critically, older adult participants were also less likely to incorporate misleading information from fellow older adult confederates. Both young and older adult participants discounted older adult confederates' contributions to a memory test.

In 2 experiments we examined the influence of frontal lobe function on older adults' susceptibility to false memory in a categorized list paradigm. Using a neuropsychological battery of tests developed by Glisky, Polster, and Routhieaux (1995), we designated older adults as having high- or low-frontal function. Young and older adults studied and were tested on categorized lists using free report cued recall and forced report cued recall instructions, with the latter requiring participants to produce responses even if they had to guess. Under free report cued recall instructions, frontal lobe function was a strong predictor of false memories in older adults: Older adults who scored low on tests of frontal functioning demonstrated much higher levels of false recall than younger adults, whereas levels of false recall in high-frontal older adults were more similar to those of young adults. However, after forced report cued recall, high- and low-frontal older adults performed similarly to each other, and both demonstrated higher levels of false recall than young adults. On a final recognition test, high-frontal older adults in both the free report cued recall and forced report cued recall conditions were more successful than low-frontal older adults in using source information to reduce memory errors. The results indicate that older adults show higher levels of false recall than younger adults, but type of test (free report or forced report) and neuropsychological status of older adults mediate these effects. Low-frontal older adults are particularly susceptible to producing false memories on free report tests that entail source monitoring.

Two experiments examined collaborative memory for information that was studied by all group members (shared items) and information that was studied by only a subset of group members (unshared items). In both experiments significant collaborative inhibition (reduced output of the collaborative groups relative to the pooled output of individuals) was obtained for both shared and unshared information. In Experiment 1 the magnitude of collaborative inhibition was larger for unshared items than for shared items, possibly because unshared items were less likely to be acknowledged and thus incorporated into the groups' recall. In Experiment 2 the magnitude of collaborative inhibition for shared and unshared information was equivalent once all participants were provided with the category name associated with the shared and unshared items. The results of the experiments are discussed in relation to the retrieval strategy disruption hypothesis of collaborative inhibition and the role of social process variables, such as acknowledgement, in influencing collaborative inhibition across situations involving memory of shared and unshared information.

This study examined possible age-related differences in recall, guessing, and metacognition on free recall tests and forced recall tests. Participants studied categorised and unrelated word lists and were asked to recall the items under one of the following test conditions: standard free recall, free recall with a penalty for guessing, free recall with no penalty for guessing, or forced recall. The results demonstrated interesting age differences regarding the impact of liberal test instructions (i.e., forced recall and no penalty) relative to more conservative test instructions (i.e., standard free recall and penalty) on memory performance. Specifically, once guessing was controlled, younger adults' recall of categorised lists varied in accordance with test instructions while older adults' recall of categorised lists did not differ between conservative and liberal test instructions, presumably because older adults approach standard free recall tests of categorised lists with a greater propensity towards guessing than young adults.

In two experiments, we examined age differences in collaborative inhibition (reduced recall in pairs of people, relative to pooled individuals) across repeated retrieval attempts. Younger and older adults studied categorized word lists and were then given two consecutive recall tests and a recognition test. On the first recall test, the subjects were given free-report cued recall or forced-report cued recall instructions (Experiment 1) or free recall instructions (Experiment 2) and recalled the lists either alone or in collaboration with another subject of the same age group. Free-report cued recall and free recall instructions warned the subjects not to guess, whereas forced-report cued recall instructions required them to guess. Collaborative inhibition was obtained for both younger and older adults on initial tests of free-report cued recall, forced-report cued recall, and free recall, showing that the effect generalizes across several tests for both younger and older adults. Collaborative inhibition did not persist on subsequent individual recall or recognition tests for list items. Older adults consistently falsely recalled and recognized items more than did younger adults, as had been found in previous studies. In addition, prior collaboration may exaggerate older adults' tendency toward higher false alarms on a subsequent recognition test, but only after a free recall test. The results provide generality to the phenomenon of collaborative inhibition and can be explained by invoking concepts of strategy disruption and source monitoring.

Background: The cornea is a specialized transparent connective tissue responsible for the majority of light refraction and image focus for the retina. There are three main layers of the cornea: the epithelium that is exposed and acts as a protective barrier for the eye, the center stroma consisting of parallel collagen fibrils that refract light, and the endothelium that is responsible for hydration of the cornea from the aqueous humor. Normal cornea is an immunologically privileged tissue devoid of blood vessels, but injury can produce a loss of these conditions causing invasion of other processes that degrade the homeostatic properties resulting in a decrease in the amount of light refracted onto the retina. Determining a measure and drift of phenotypic cornea state from normal to an injured or diseased state requires knowledge of the existing protein signature within the tissue. In the study of corneal proteins, proteomics procedures have typically involved the pulverization of the entire cornea prior to analysis. Separation of the epithelium and endothelium from the core stroma and performing separate shotgun proteomics using liquid chromatography/mass spectrometry results in identification of many more proteins than previously employed methods using complete pulverized cornea., Results: Rabbit corneas were purchased, the epithelium and endothelium regions were removed, proteins processed and separately analyzed using liquid chromatography/mass spectrometry. Proteins identified from separate layers were compared against results from complete corneal samples. Protein digests were separated using a six hour liquid chromatographic gradient and ion-trap mass spectrometry used for detection of eluted peptide fractions. The SEQUEST database search results were filtered to allow only proteins with match probabilities of equal or better than 10-3 and peptides with a probability of 10-2 or less with at least two unique peptides isolated within the run along with default Xcorr values. These parameters resulted in the identification of over 350 proteins, including over 225 new proteins not previously detected in the cornea by mass spectrometry. In addition, corneal layer separation resulted in identification of nearly every protein that was identified in the complete cornea assay. The epithelium and endothelium each revealed many unique proteomes specific to each layer. In the endothelium, the protein olfactomedin-like 3 was identified for the first time in the cornea by this analysis. Olfactomedin-3 is a neuronal expressed protein also known as optimedin that stimulates formation of cell adherent and cell-cell tight junctions and its expression modulates cytoskeleton organization and cell migration. However, the function of this protein in rabbit corneal endothelium is currently unknown., Conclusion: This manuscript presents a description of a more comprehensive proteomic profile for mammalian cornea compared to past methods. The use of simple dissection procedures of the tissue and the application of long chromatographic gradients, many more proteins can be identified.

The effect of expertise on collaborative memory was examined by comparing expert pilots, novice pilots, and non-pilots. Participants were presented with aviation scenarios and asked to recall the scenarios alone or in collaboration with a fellow participant of the same expertise level. Performance in the collaborative condition was compared to nominal group conditions (i.e., pooled individual performance). Results suggest that expertise differentially impacts collaborative memory performance. Non-experts (non-pilots and novices) were relatively disrupted by collaboration, while experts showed a benefit of collaboration. Verbal protocol analyses identified mechanisms related to collaborative skill and domain knowledge that may underlie experts' collaborative success. Specifically, experts were more likely than non-experts to explicitly acknowledge partner contributions by repeating back previously made statements, as well as to further elaborate on concepts in those contributions. The findings are interpreted according to the retrieval strategy disruption theory of collaborative memory and theories of grounding in communication.

The effect of an initial forced recall test on later recall and recognition tests was examined in younger and older adults. Subjects were presented with categorized word lists and given an initial test under standard cued recall instructions (with a warning against guessing) or forced recall instructions (that required guessing); subjects were later given a cued recall test for the original list items. In 2 experiments, initial forced recall resulted in higher levels of illusory memories on subsequent tests (relative to initial cued recall), especially for older adults. Older adults were more likely to say they remembered rather than knew that forced guesses had occurred in the original study episode. The effect persisted despite a strong warning against making errors in Experiment 2. When a source monitoring test was given, older adults had more difficulty than younger adults in identifying the source of items they had originally produced as guesses. If conditions encourage subjects to guess on a first memory test, they are likely to recollect these guesses as actual memories on later tests. This effect is exaggerated in older adults, probably because of their greater source monitoring difficulties. Both dual process and source monitoring theories provide insight into these findings.

The forced-recall paradigm requires participants to fill all spaces on the memory test even if they cannot remember all the list words. In the present study, the authors used that paradigm to examine the influence of implicit memory on guessing--when participants fill remaining spaces after they cannot remember list items. They measured explicit memory as the percentage of targets that participants designated as remembered from the list and implicit memory as the percentage of targets they wrote but did not designate as remembered (beyond chance level). The authors examined implicit memory on guessing with forced recall (Experiment 1), forced cued recall with younger and older adults (Experiment 2), and forced free and cued recall under a depth-of-processing manipulation (Experiment 3). They conclude that implicit memory influences guesses of targets in the forced-recall paradigm.

In this study, we examined how implicit and explicit memory for perceptual information (modality and voice) and lexical information varied across three subject groups: healthy young adults, healthy older adults, and age-matched older adults with dementia of the Alzheimer's type (DAT). These groups exhibited cross-modality (abstract) priming of the same magnitude. However, young adults produced greater modality- and voice-specific priming than the other two groups, whose performance was equivalent, suggesting that aging, but not DAT, reduced form-specific priming. Young adults demonstrated better recognition memory than healthy older adults, who in turn exhibited better recognition memory than older adults with DAT. In young adults, recognition memory was also sensitive to perceptual information. These findings indicate that aging can affect implicit memory for perceptual information, whereas DAT magnifies the effect of aging on explicit memory.

Four experiments examined social influence on the development of false memories. We employed the social contagion paradigm: A subject and a confederate see scenes and then later take turns recalling items from the scenes, with the confederate erroneously reporting some items that were not present in the scenes; on a final test, the subject reports these suggested items when instructed to recall only items from the scenes. The first two experiments showed that the social contagion effect persisted when subjects were explicitly warned about the possibility that confederates' responses might induce false memories and when they were tested via source-monitoring tests that explicitly gave the choice of attributing suggested items to the other person. Levels of false recall and recognition increased with the number of times the misleading information was suggested (Experiment 3), and subjects were more likely to incorporate the erroneous responses of an actual confederate on a recognition/source test as compared with those of a simulated confederate (Experiment 4). Collectively, the data support the claim that false memories may be transmitted between people and reveal critical factors that modulate the social contagion of memories.

We report a new paradigm for studying false memories implanted by social influence, a process we call the social contagion of memory. A subject and confederate together saw six common household scenes (e.g., a kitchen) containing many objects, for either 15 or 60 sec. During a collaborative recall test, the 2 subjects each recalled six items from the scenes, but the confederate occasionally made mistakes by reporting items not from the scene. Some intrusions were highly consistent with the scene schema (e.g., a toaster) while others were less so (e.g., oven mitts). After a brief delay, the individual subject tried to recall as many items as possible from the six scenes. Recall of the erroneous items suggested by the confederate was greater than in a control condition (with no suggestion). Further, this social contagion effect was greater when the scenes were presented for less time (15 sec) and when the intruded item was more schema consistent (e.g., the toaster). As with other forms of social influence, false memories are contagious; one person's memory can be infected by another person's errors.