1. Evaluation of the Pharmaceutical Quality of Different Brands of Ranitidine Tablets Manufactured in Bangladesh: A Pharmaceutical and Public Health Prospective
- Author
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Masud Rana, Nahlah Elkudssiah Ismail, Abu Nayem Md. Al-Noman Howlader, Md. Moklesur Rahman Sarker, Mohammed Faisal Bin Karim, Rehana Akter, Ali Asghar Raju, Md. Salman Rashid, and Long Chiau Ming
- Subjects
medicine.medical_specialty ,media_common.quotation_subject ,030231 tropical medicine ,Medicine (miscellaneous) ,law.invention ,Ranitidine ,03 medical and health sciences ,0302 clinical medicine ,Drug control ,law ,Medicine ,Pharmacology (medical) ,Quality (business) ,General Pharmacology, Toxicology and Pharmaceutics ,health care economics and organizations ,media_common ,Active ingredient ,Traditional medicine ,business.industry ,Public health ,Drug Counterfeiting ,Ranitidine Hydrochloride ,Pharmacopoeia ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Drug counterfeiting and production of substandard drug is a global problem. This study was aimed to assess the pharmaceutical quality of ranitidine hydrochloride tablets manufactured in Bangladesh. Tablets were collected from different parts of Bangladesh and quality parameters were evaluated according to the United States Pharmacopoeia and the British Pharmacopoeial methods. The potency of tablets was measured spectrophotometrically. Weight variation and disintegration time were performed according to pharmaceutical monographs. Among 43 brands tested, 8 failed to comply with the USP specification (active ingredient: 90±10%) due to containing of less amount of ranitidine of which 6 brands were spurious and 2 were substandard in nature. Two brands did not comply with the specification for weight variation of tablets whereas all brands passed disintegration time test. The findings clearly demonstrate the production of substandard ranitidine tablets in Bangladesh. The drug control authority of Bangladesh should take effective steps to prevent the production of substandard drugs to secure public health.
- Published
- 2016
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