16 results on '"Md. Ali Mujtaba"'
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2. A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer
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Sudharshan Reddy Dachani, Mohammed Kaleem, Md. Ali Mujtaba, Nilesh Mahajan, Sayyed A. Ali, Ali F Almutairy, Danish Mahmood, Md. Khalid Anwer, Mohammad Daud Ali, and Sanjay Kumar
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Chemistry ,QD1-999 - Published
- 2024
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3. Novel Therapeutic Approach in PEGylated Chitosan Nanoparticles of Apigenin for the Treatment of Cancer via Oral Nanomedicine
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Md Ali Mujtaba, Nawaf M. Alotaibi, Sultan M. Alshehri, Mohammad Yusuf, Md Khalid Anwer, Mohammad Akhlaquer Rahman, and Arshiya Parveen
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apigenin ,Box–Behnken design ,antioxidant ,chitosan ,nanoparticles ,Organic chemistry ,QD241-441 - Abstract
The goal of this study was to optimize and formulate apigenin (APG)-loaded pegylated chitosan nanoparticles (PEGylated-CNPs) via ionic gelation techniques using the Box–Behnken design (BBD). Three individual variables, X1(chitosan: TPP concentration), X2 (PEG-400 concentration), and X3 (sonication time), were investigated for their influence on response variables (Y1—particle size (PS); Y2—drug entrapment efficiency (DEE); and Y3—zeta potential (ZP). The optimized formula of APG-PEGylated CNPs was picked from the statistical design and was then examined for physical, morphological, release characterization, anti-oxidant, and anti-tumor potential. The average PS, PDI, %DEE, and ZP were found to be 139.63 ± 5.67 nm, 0.296 ± 0.014, 79.55 ± 3.12%, and 24.68 ± 1.84 mV, respectively. The optimized APG formulation was chosen and reformulated based on the desirability function. Results of the observed and predicted values of responses through the BBD process were found to be nearly identical. The resulting APG-PEGylated CNPs were spherical and smooth, according to surface morphology studies. The release study revealed that PEGylated-CNPs exhibited biphasic release patterns distinguished by an initial burst release of APG only at early phases accompanied by a delayed release near 24 h. Furthermore, APG-PEGylated CNPs demonstrated statistically increased antioxidant activities and cytotoxicity against MCF-7 cells compared to pure APG. Based on the findings, it is possible to conclude that BBD was efficient in optimizing the PEGylated CNPs formulation and recognizing the impacts of formulation variables. In conclusion, the developed formulation has a significant potential for anticancer therapy.
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- 2022
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4. A Systematic Review of Chronic Diseases and Their Prevalence Among the Population of Northern Borders Province (NBP) in Saudi Arabia
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Ebtihag O Alenzi, Waseem Fatima, Abdelbasset Amara, Mohd Imran, Syed Sajid Hussain Shah, Amal Ahmed Elbilgahy, Manal S Fawzy, Lobna M Abu-Negm, Md Ali Mujtaba, Ingrid Jacinto-Caspillo, and Awdah M Al-Hazimi
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General Medicine ,General Nursing - Published
- 2023
5. Antibacterial efficacy of garlic oil nano-emulsion
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Khidir A.M. Hassan and MD Ali Mujtaba
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garlic oil nano-emulsion ,essential oils ,anti-bacterial ,characteristics ,properties ,Agriculture (General) ,S1-972 ,Food processing and manufacture ,TP368-456 - Abstract
Garlic oils have promising possibilities for a wide range of applications in the food and pharmaceutical industries. Their widespread utilization is limited as they are lipophilic and highly volatile. Furthermore, they also possess strong odor and low physicochemical stability. Therefore, the present study aims to investigate the characteristics of garlic oil nano-emulsion through investigating its antibacterial activity. The emulsion was prepared and the size distribution and zeta potential of the nanoparticles were investigated using a Nicomp Z3000 particle size analyzer. S. aureus and E. coli specimens were impregnated with garlic oil and garlic oil nano-emulsions. The results indicated that the mean particle diameter was 36.3 nm, polydispersity index was 0.527, and average zeta potential was −26.23 mV. Garlic oil nano-emulsion was more effective against S. aureus than E. coli. Moreover, the antibacterial activity of garlic oil nano-emulsion was lower than regular garlic oil. The study concluded that modifications are to be made with respect to particle size, concentration, and zeta potential.
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- 2019
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6. Development, Characterization, and Evaluation of α-Mangostin-Loaded Polymeric Nanoparticle Gel for Topical Therapy in Skin Cancer
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Shadab Md, Nabil A. Alhakamy, Thikryat Neamatallah, Samah Alshehri, Md Ali Mujtaba, Yassine Riadi, Ammu K. Radhakrishnan, Habibullah Khalilullah, Manish Gupta, and Md Habban Akhter
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α-Mangostin ,polymeric nanoparticle ,skin cancer ,gel ,Behnken design ,MTT assay ,Science ,Chemistry ,QD1-999 ,Inorganic chemistry ,QD146-197 ,General. Including alchemy ,QD1-65 - Abstract
The aim of this study was to prepare and evaluate α-mangostin-loaded polymeric nanoparticle gel (α-MNG-PLGA) formulation to enhance α-mangostin delivery in an epidermal carcinoma. The poly (D, L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were developed using the emulsion–diffusion–evaporation technique with a 3-level 3-factor Box–Behnken design. The NPs were characterized and evaluated for particle size distribution, zeta potential (mV), drug release, and skin permeation. The formulated PLGA NPs were converted into a preformed carbopol gel base and were further evaluated for texture analysis, the cytotoxic effect of PLGA NPs against B16-F10 melanoma cells, and in vitro radical scavenging activity. The nanoscale particles were spherical, consistent, and average in size (168.06 ± 17.02 nm), with an entrapment efficiency (EE) of 84.26 ± 8.23% and a zeta potential of −25.3 ± 7.1 mV. Their drug release percentages in phosphate-buffered solution (PBS) at pH 7.4 and pH 6.5 were 87.07 ± 6.95% and 89.50 ± 9.50%, respectively. The release of α-MNG from NPs in vitro demonstrated that the biphasic release system, namely, immediate release in the initial phase, was accompanied by sustained drug release. The texture study of the developed α-MNG-PLGA NPs gel revealed its characteristics, including viscosity, hardness, consistency, and cohesiveness. The drug flux from α-MNG-PLGA NPs gel and α-MNG gel was 79.32 ± 7.91 and 16.88 ± 7.18 µg/cm2/h in 24 h, respectively. The confocal study showed that α-MNG-PLGA NPs penetrated up to 230.02 µm deep into the skin layer compared to 15.21 µm by dye solution. MTT assay and radical scavenging potential indicated that α-MNG-PLGA NPs gel had a significant cytotoxic effect and antioxidant effect compared to α-MNG gel (p < 0.05). Thus, using the developed α-MNG-PLGA in treating skin cancer could be a promising approach.
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- 2021
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7. Stability Testing of Amoxicillin Nano-suspension as Promising Tool for Drug Delivery System
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Md Ali Mujtaba and Lina Eltaib
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While nano-suspension amoxicillin is one of the approaches for improving dissolution rate of amoxicillinan antibiotic used widely. Stabilizing these nanodosage forms is always a challenge. The present study utilizes nanoprecipitation solvent evaporation technique for preparation of amoxicillin nanoparticles andproposed stability study approach of the same. The methodology was based on investigating stability of amoxicillin nano suspension in vitro, the optimized drug(polymer ratio re-formulated into nano-suspensions) and we compared our results with marketed suspensions. Samples were initially characterized and then subjected to stability testing at ambient temperature and relative humidity up to 6 months assayed using a validated HPLC method. During initial characterization, increase in saturation solubility and dissolution rate observed in all samples. During stability testing, there was gradual decrease in saturation solubility and dissolution rate of the samples, over the period of 3 months. This study considers long-term isothermal measurements, consistent with short-term non-isothermal (accelerating) measurements, providing predictive model to calculate the isothermal degradation periods. As per our results, we agree with the possibility to calculate the value of kinetic constants based on a fixed degradation limit, regardless of the shape of the curve. The accuracy of the prediction would be assessed by comparison of estimated shelf life versus data coming from traditional stability studies.
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- 2021
8. An Updated Review on Therapeutic Potential and Recent Advances in Drug Delivery of Berberine: Current Status and Future Prospect
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Md Ali Mujtaba
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- 2021
9. List of contributors
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Syed Sufian Ahmad, Faraha Ahmed, Hibah M. Aldawsari, Nabil A. Alhakamy, Javed Ali, Sanjula Baboota, Samir Bhargava, null Bhavna, Shweta Dang, Anmol Dogra, G.N.K. Ganesh, Sonal Gupta, Abdullah Habeeballah, Shrikant Joshi, Gajanan Kalyankar, Shahid Karim, Mohammad Ahmed Khan, Sabna Kotta, Shobhit Kumar, Sandesh Lodha, Shadab Md, Ashish Mishra, Suresh K. Mohankumar, Md Ali Mujtaba, Gulam Mustafa, Jasjeet Kaur Narang, Abhijeet Ojha, Hetal Patel, Syed Arman Rabbani, Sadat Shafi, Rajesh Sharma, Shrestha Sharma, and Harmanpreet Singh
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- 2022
10. Solid-Phase Extraction (SPE) Technique to Quantify Cefdinir in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
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Md Tauquir Alam, Md Ali Mujtaba, Afzal Hussain, Abuzer Ali, Mohd Imran, Md Abul Barkat, and Sherif A Abdel-Gawad
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General Medicine ,Analytical Chemistry - Abstract
A biosensitive analysis method development and validation was performed for accurate and rapid quantification of cefdinir (CDR) in human plasma by a liquid chromatography–tandem mass spectrometry technique coupled with electrospray ionization. Analysis was carried out using a C18 column with a flow rate of 1.0 mL/min and operating temperature of 30.0 ± 1°C. The drug was eluted by optimizing the m/z ratios of 396.20 → 227.20 and 428.17 → 241.10, for cefdinir and IS (internal standard), respectively. The intraday precision (%CV) for Cefdinir ranged from 2.8% and 6.7% as lower limit of quantification of quality control (LLOQ QC) and higher level of quantification of quality control (HQC QC), respectively, whereas these value were found to be as 3.0% and 5.6% for LLOQ and HQC, respectively after interday precision. Moreover, accuracy ranged from 107.70% (HQC QC) to 95.5% (LLOQ QC). The extraction mean recovery was found to be 83.91 ± 6.0% for cefdinir and 76.7 ± 6.23% for IS. The drug was stable throughout the analysis period. It was possible to analyze several plasma samples every day since each sample took
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- 2021
11. Nanoemulsions to Preserve/Process Bioactive and Nutritional Food Compounds: Contemporary Research and Applications
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Farrukh Zeeshan, Nabil A. Alhakamy, Md. Ali Mujtaba, Shadab, Wei-Meng Lim, and Khaled M. Hosny
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Engineering ,business.industry ,Process (engineering) ,Biochemical engineering ,business - Published
- 2021
12. Molecular Targets and Nanoparticulate Systems Designed for the Improved Therapeutic Intervention in Glioblastoma Multiforme
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Md. Habban Akhter, Md. Ali Mujtaba, Saima Amin, Javed Ahmad, Mohammad Zaki Ahmad, Md. Rizwanullah, Javed Ali, and Md. Akram Minhaj
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Drug ,Polymers ,medicine.medical_treatment ,media_common.quotation_subject ,Antineoplastic Agents ,02 engineering and technology ,03 medical and health sciences ,0302 clinical medicine ,Cell Line, Tumor ,Drug Discovery ,Biomarkers, Tumor ,Medicine ,Animals ,Humans ,Molecular Targeted Therapy ,Adverse effect ,media_common ,Chemotherapy ,Drug Carriers ,business.industry ,Brain Neoplasms ,Cancer ,General Medicine ,Genetic Therapy ,021001 nanoscience & nanotechnology ,medicine.disease ,Lipids ,Xenograft Model Antitumor Assays ,Blood-Brain Barrier ,030220 oncology & carcinogenesis ,Drug delivery ,Cancer research ,Molecular targets ,Nanoparticles ,0210 nano-technology ,business ,Glioblastoma ,Drug metabolism - Abstract
Glioblastoma multiforme (GBM) is the most aggressive and fatal CNS related tumors, which is responsible for about 4% of cancer-related deaths. Current GBM therapy includes surgery, radiation, and chemotherapy. The effective chemotherapy of GBM is compromised by two barriers, i. e., the blood-brain barrier (BBB) and the blood tumor barrier (BTB). Therefore, novel therapeutic approaches are needed. Nanoparticles are one of the highly efficient drug delivery systems for a variety of chemotherapeutics that have gained massive attention from the last three decades. Perfectly designed nanoparticles have the ability to cross BBB and BTB and precisely deliver the chemotherapeutics to GBM tissue/cells. Nanoparticles can encapsulate both hydrophilic and lipophilic drugs, genes, proteins, and peptides, increase the stability of drugs by protecting them from degradation, improve plasma half-life, reduce adverse effects and control the release of drugs/genes at the desired site. This review focussed on the different signaling pathways altered in GBM cells to understand the rationale behind selecting new therapeutic targets, challenges in the drug delivery to the GBM, various transport routes in brain delivery, and recent advances in targeted delivery of different drug and gene loaded various lipidic, polymeric and inorganic nanoparticles in the effective management of GBM.
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- 2020
13. Epidemiology, risk, myths, pharmacotherapeutic management and socio economic burden due to novel COVID-19: A recent update
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Ambreen Shoaib, Md. Ali Mujtaba, Mohammad Daud Ali, Nawazish Alam, Md. Sarfaraz Alam, Md. Sajid Ali, Sarfaraz Ahmad, M. Ali, Ayaz Ahmad, and Md. Salahuddin Ansari
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medicine.medical_specialty ,business.industry ,Public health ,International community ,Outbreak ,Disease ,Review article ,Epidemiology ,Pandemic ,medicine ,Pharmacology (medical) ,China ,Socioeconomics ,business ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) - Abstract
The novel human coronavirus disease (COVID-19) is the major pandemic throughout the globe and its occurrence is due to the presence of severe acute respiratory syndrome coronavirus (SARS-CoV2). That began from Wuhan, Hubei province of China in late 2019 and afterward drastically spread worldwide. It effects around 213 countries and territories around the globe and have reported a total of 8,128,490 confirmed cases of COVID-19. As an unprecedented global pandemic it sweeps the planet and affects each and every human being either physically, mentally or economically. The most common symptoms of COVID-19 are pyrexia, tiredness, and dry cough but in some cases it is asymptomatic. It can be diagnosed by a health care provider based on symptoms and confirmed through laboratory tests. Till date there is not even a single drug or vaccine that can be used for the effective treatment for this disease. The international community is to introduce a global synchronized strength to prevent the outbreak that needs a strong public health response, high level political commitment and sufficient funding. The aim of this review article is to summarise the recent state of awareness, epidemiology and social impact on surrounding due to outbreak of COVID-19 pandemic.
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- 2020
14. Nanocarriers in advanced drug targeting: setting novel paradigm in cancer therapeutics
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Javed Ahmad, Md. Rizwanullah, Md. Habban Akhter, Md. Ali Mujtaba, Saima Amin, and Mohamed Jawed Ahsan
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Combination therapy ,medicine.medical_treatment ,Biomedical Engineering ,Pharmaceutical Science ,Medicine (miscellaneous) ,Nanotechnology ,02 engineering and technology ,03 medical and health sciences ,0302 clinical medicine ,Drug Delivery Systems ,Neoplasms ,medicine ,Animals ,Humans ,Drug Carriers ,business.industry ,Cancer ,General Medicine ,021001 nanoscience & nanotechnology ,medicine.disease ,Nanoshell ,Nanostructures ,Radiation therapy ,Targeted drug delivery ,030220 oncology & carcinogenesis ,Drug delivery ,Nanomedicine ,Nanocarriers ,0210 nano-technology ,business ,Biotechnology - Abstract
Cancer has been growing nowadays consequently high number of death ascertained worldwide. The medical intervention involves chemotherapy, radiation therapy and surgical removal. This conventional technique lacking targeting potential and harm the normal cells. In drug treatment regimen, the combination therapy is preferred than single drug treatment module due to higher internalization of chemotherapeutics in the cancer cells both by enhance permeation retention effect and by direct cell apoptosis. The cancer therapeutics involves different methodologies of delivering active moiety to the target site. The active and passive transport mode of chemotherapeutic targeting utilizes advance nanocarriers. The nanotechnological strategic treatment applying advance nanocarrier greatly helps in mitigating the cancer prevalence. The nanocarrier-incorporating nanodrug directed for specific area appealed scientist across the globe and issues to be addressed in this regard. Therefore, various techniques and approaches invented to meet the objectives. With the advances in nanomedicine and drug delivery, this review briefly focused on various modes of nanodrug delivery including nanoparticles, liposomes, dendrimer, quantum dots, carbon nanotubes, metallic nanoparticles, nanolipid carrier (NLC), gold nanoshell, nanosize cantilevers and nanowire that looks promising and generates a novel horizon in cancer therapeutics.
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- 2017
15. Self-Emulsifying Drug Delivery System for Enhanced Oral Delivery of Tenofovir: Formulation, Physicochemical Characterization, and Bioavailability Assessment
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Nilesh Mahajan, Md Ali Mujtaba, Ritesh Fule, Sonali Thakre, Md Sayeed Akhtar, Sirajudeen S. Alavudeen, Md Khalid Anwer, Mohammed F. Aldawsari, Danish Mahmood, and Md Sarfaraz Alam
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Chemistry ,QD1-999 - Published
- 2024
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16. Nanovesicles based drug targeting to control tumor growth and metastasis
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Azim Ansari, Afzal Hussain, Raju Wadekar, Mohammad A. Altamimi, Abdul Malik, Md Ali Mujtaba, Mohammad Yousuf Ansari, Mohd Usman Mohd Siddique, and Sameer N. Goyal
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Cancers ,Nanovesicles ,Mechanistic perspectives of absorption ,Exosomes and neutrophils ,Combination therapy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Cancer is still a global challenge for healthcare professional and scientists due to complicated pathological pathways, inefficient early diagnosis, and limited safe delivery system at economic treatment cost. Despite these, other factors (life style, environmental problem, socio-economic issues, patient related complications, expensive therapy, and genetic history of oncogene) played significant role to spread and complicate treatment. However, various novel carriers have been explored and reported for effective and efficient drug delivery using polymers and lipid. Among them, vesicular systems are considered as the most biocompatible and safe for delivery of hydrophilic and lipophilic drug candidates. Therefore, the present review addressed various forms of nanovesicular systems with their benefits, progressive development stages, and mechanistic insights for drug targeting (active and passive), specific cancer wise nanovesicles, exosomes, and commercial products with potential clinical applications. The review primarily highlighted the major findings of nanovesicles employed to control solid tumor when a chemotherapeutic drug was used in specific vesicles based nanocarriers. Notably, miscellaneous exosomes, blood cells-based drug delivery (neutrophils and leukocytes), pH-responsive nanovesicles improved drug therapy by targeting tumor tissues and high drug access in the site of action. Finally, co-administration of chemotherapeutic drugs (combination therapy) further revealed convincing therapeutic outcomes as compared to standalone.
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- 2023
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