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3,678 results on '"Mcintyre, Roger S."'

5. Assessing the Effects of Metabolic Disruption, Body Mass Index and Inflammation on Depressive Symptoms in Post-COVID-19 Condition: A Randomized Controlled Trial on Vortioxetine

Author

Kwan, Angela T. H., Guo, Ziji, Ceban, Felicia, Le, Gia Han, Wong, Sabrina, Teopiz, Kayla M., Rhee, Taeho Greg, Ho, Roger, Di Vincenzo, Joshua D., Badulescu, Sebastian, Meshkat, Shakila, Cao, Bing, Rosenblat, Joshua D., d’Andrea, Giacomo, Dev, Donovan A., Phan, Lee, Subramaniapillai, Mehala, and McIntyre, Roger S.

Published
2024
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9. Consciousness, Memory, and Intelligence

Author

Gill, Hartej, McIntyre, Roger S., Fiorillo, Andrea, Section editor, McGorry, Patrick D., Section editor, Volpe, Umberto, Section editor, Tasman, Allan, editor, Riba, Michelle B., editor, Alarcón, Renato D., editor, Alfonso, César A., editor, Kanba, Shigenobu, editor, Lecic-Tosevski, Dusica, editor, Ndetei, David M., editor, Ng, Chee H., editor, and Schulze, Thomas G., editor

Published
2024
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17. The clinical characterization of the adult patient with bipolar disorder aimed at personalization of management

Author

McIntyre, Roger S, Alda, Martin, Baldessarini, Ross J, Bauer, Michael, Berk, Michael, Correll, Christoph U, Fagiolini, Andrea, Fountoulakis, Kostas, Frye, Mark A, Grunze, Heinz, Kessing, Lars V, Miklowitz, David J, Parker, Gordon, Post, Robert M, Swann, Alan C, Suppes, Trisha, Vieta, Eduard, Young, Allan, and Maj, Mario

Subjects
Health Services and Systems, Health Sciences, Clinical Research, Serious Mental Illness, Patient Safety, Prevention, Behavioral and Social Science, Suicide, Mental Health, Brain Disorders, Management of diseases and conditions, 7.3 Management and decision making, 7.1 Individual care needs, Mental health, Good Health and Well Being, Bipolar disorder, clinical characterization, phenotyping, subtypes, mixed features, cognition, rapid cycling, trauma, comorbidity, social determinants, stigma, stressors, resilience, bipolar I disorder, bipolar II disorder, mania, depression, personalization, Clinical Sciences, Psychiatry, Clinical sciences, Health services and systems
Abstract

Bipolar disorder is heterogeneous in phenomenology, illness trajectory, and response to treatment. Despite evidence for the efficacy of multimodal-ity interventions, the majority of persons affected by this disorder do not achieve and sustain full syndromal recovery. It is eagerly anticipated that combining datasets across various information sources (e.g., hierarchical "multi-omic" measures, electronic health records), analyzed using advanced computational methods (e.g., machine learning), will inform future diagnosis and treatment selection. In the interim, identifying clinically meaningful subgroups of persons with the disorder having differential response to specific treatments at point-of-care is an empirical priority. This paper endeavours to synthesize salient domains in the clinical characterization of the adult patient with bipolar disorder, with the overarching aim to improve health outcomes by informing patient management and treatment considerations. Extant data indicate that characterizing select domains in bipolar disorder provides actionable information and guides shared decision making. For example, it is robustly established that the presence of mixed features - especially during depressive episodes - and of physical and psychiatric comorbidities informs illness trajectory, response to treatment, and suicide risk. In addition, early environmental exposures (e.g., sexual and physical abuse, emotional neglect) are highly associated with more complicated illness presentations, inviting the need for developmentally-oriented and integrated treatment approaches. There have been significant advances in validating subtypes of bipolar disorder (e.g., bipolar I vs. II disorder), particularly in regard to pharmacological interventions. As with other severe mental disorders, social functioning, interpersonal/family relationships and internalized stigma are domains highly relevant to relapse risk, health outcomes, and quality of life. The elevated standardized mortality ratio for completed suicide and suicidal behaviour in bipolar disorder invites the need for characterization of this domain in all patients. The framework of this paper is to describe all the above salient domains, providing a synthesis of extant literature and recommendations for decision support tools and clinical metrics that can be implemented at point-of-care.

Published
2022

32. Association between cognitive functioning, suicidal ideation and suicide attempts in major depressive disorder, bipolar disorder, schizophrenia and related disorders: A systematic review and meta-analysis

Author

Le, Gia Han, Wong, Sabrina, Haikazian, Sipan, Johnson, Danica E., Badulescu, Sebastian, Kwan, Angela T.H., Gill, Hartej, Di Vincenzo, Joshua D., Rosenblat, Joshua D., Mansur, Rodrigo, Teopiz, Kayla M., Rhee, Taeho Greg, Ho, Roger, Liao, Sonya, Cao, Bing, Schweinfurth-Keck, Nina, Vinberg, Maj, Grande, Iria, Phan, Lee, d'Andrea, Giacomo, and McIntyre, Roger S.

Published
2024
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36. Spectral signatures of psilocybin, lysergic acid diethylamide (LSD) and ketamine in healthy volunteers and persons with major depressive disorder and treatment-resistant depression: A systematic review

Author

Le, Gia Han, Wong, Sabrina, Badulescu, Sebastian, Au, Hezekiah, Di Vincenzo, Joshua D., Gill, Hartej, Phan, Lee, Rhee, Taeho Greg, Ho, Roger, Teopiz, Kayla M., Kwan, Angela T.H., Rosenblat, Joshua D., Mansur, Rodrigo B., and McIntyre, Roger S.

Published
2024
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37. Anxious and depressive symptoms and health-related quality of life in a cohort of people who recently attempted suicide: A network analysis

Author

Oliva, Vincenzo, Roberto, Natalia, Andreo-Jover, Jorge, Bobes, Teresa, Canal Rivero, Manuel, Cebriá, Anabel, Crespo-Facorro, Benedicto, de la Torre-Luque, Alejandro, Díaz-Marsá, Marina, Elices, Matilde, Fernández-Rodrigues, Verónica, Gonzalez-Pinto, Ana, Palao Tarrero, Angela, Pérez-Diez, Iván, Rodríguez-Vega, Beatriz, Ruiz-Veguilla, Miguel, Saiz, Pilar A., Seijo-Zazo, Elisa, Toll-Privat, Alba, McIntyre, Roger S., Vieta, Eduard, Grande, Iria, and Pérez-Solà, Víctor

Published
2024
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47. A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials

Author

Sforzini, Luca, Worrell, Courtney, Kose, Melisa, Anderson, Ian M, Aouizerate, Bruno, Arolt, Volker, Bauer, Michael, Baune, Bernhard T, Blier, Pierre, Cleare, Anthony J, Cowen, Philip J, Dinan, Timothy G, Fagiolini, Andrea, Ferrier, I Nicol, Hegerl, Ulrich, Krystal, Andrew D, Leboyer, Marion, McAllister-Williams, R Hamish, McIntyre, Roger S, Meyer-Lindenberg, Andreas, Miller, Andrew H, Nemeroff, Charles B, Normann, Claus, Nutt, David, Pallanti, Stefano, Pani, Luca, Penninx, Brenda WJH, Schatzberg, Alan F, Shelton, Richard C, Yatham, Lakshmi N, Young, Allan H, Zahn, Roland, Aislaitner, Georgios, Butlen-Ducuing, Florence, Fletcher, Christine, Haberkamp, Marion, Laughren, Thomas, Mäntylä, Fanni-Laura, Schruers, Koen, Thomson, Andrew, Arteaga-Henríquez, Gara, Benedetti, Francesco, Cash-Gibson, Lucinda, Chae, Woo Ri, De Smedt, Heidi, Gold, Stefan M, Hoogendijk, Witte JG, Mondragón, Valeria Jordán, Maron, Eduard, Martynowicz, Jadwiga, Melloni, Elisa, Otte, Christian, Perez-Fuentes, Gabriela, Poletti, Sara, Schmidt, Mark E, van de Ketterij, Edwin, Woo, Katherine, Flossbach, Yanina, Ramos-Quiroga, J Antoni, Savitz, Adam J, and Pariante, Carmine M

Subjects
Clinical Trials and Supportive Activities, Depression, Clinical Research, Mental Health, Brain Disorders, Serious Mental Illness, Major Depressive Disorder, Good Health and Well Being, Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant, Humans, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the present document we used a Delphi-method-based consensus approach to define TRD and PRD and to serve as operational criteria for future clinical studies, especially if conducted for regulatory purposes. We reviewed the literature and brought together a group of international experts (including clinicians, academics, researchers, employees of pharmaceutical companies, regulatory bodies representatives, and one person with lived experience) to evaluate the state-of-the-art and main controversies regarding the current classification. We then provided recommendations on how to design clinical trials, and on how to guide research in unmet needs and knowledge gaps. This report will feed into one of the main objectives of the EUropean Patient-cEntric clinicAl tRial pLatforms, Innovative Medicines Initiative (EU-PEARL, IMI) MDD project, to design a protocol for platform trials of new medications for TRD/PRD.

Published
2022

48. Making Sense of the Matrix: A Qualitative Assessment and Commentary on Connecting Psychiatric Symptom Scale Items to the Research Domain Criteria (RDoC).

Author

Citrome, Leslie, Abi-Dargham, Anissa, Bilder, Robert M, Duffy, Ruth A, Dunlop, Boadie W, Harvey, Philip D, Pizzagalli, Diego A, Tamminga, Carol A, McIntyre, Roger S, and Kane, John M

Subjects
Biological Psychology, Clinical and Health Psychology, Psychology, Applied and Developmental Psychology, Brain Disorders, Mental Health, Good Health and Well Being, Research domain criteria, anxiety, depression, mental disorder, psychosis, rating scales
Abstract

The Research Domain Criteria (RDoC) initiative aims to organize research according to domains of brain function. Dysfunction within these domains leads to psychopathology that is classically measured with rating scales. Examining the correspondence between the specific measures assessed within rating scales and RDoC domains is necessary to assess the needs for new RDoC-focused scales. Such RDoC-focused scales have the potential of allowing translation of this work into the clinical domain of measuring psychopathology and designing treatment. Here, we describe an initial qualitative assessment by a group of 10 clinician-scientists of the alignment between RDoC domains and the items within five commonly used rating scales. In this commentary, we report limited correspondence and make recommendations for future work needed to address these limitations.

Published
2022

49. Psilocybin-assisted psychotherapy for treatment resistant depression: A randomized clinical trial evaluating repeated doses of psilocybin

Author

Rosenblat, Joshua D., Meshkat, Shakila, Doyle, Zoe, Kaczmarek, Erica, Brudner, Ryan M., Kratiuk, Kevin, Mansur, Rodrigo B., Schulz-Quach, Christian, Sethi, Rickinder, Abate, Amanda, Ali, Shaun, Bawks, Jordan, Blainey, Marc G., Brietzke, Elisa, Cronin, Victoria, Danilewitz, Jessica, Dhawan, Shalini, Di Fonzo, Anthony, Di Fonzo, Melissa, Drzadzewski, Pawel, Dunlop, William, Fiszter, Hajnalka, Gomes, Fabiano A., Grewal, Smrita, Leon-Carlyle, Marisa, McCallum, Marilyn, Mofidi, Niki, Offman, Hilary, Riva-Cambrin, Jeremy, Schmidt, Joel, Smolkin, Mark, Quinn, Joan M., Zumrova, Andrea, Marlborough, Michelle, and McIntyre, Roger S.

Published
2024
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50. The rapid antidepressant effectiveness of repeated dose of intravenous ketamine and intranasal esketamine: A post-hoc analysis of pooled real-world data

Author

d'Andrea, Giacomo, Pettorruso, Mauro, Di Lorenzo, Giorgio, Rhee, Taeho Greg, Chiappini, Stefania, Carullo, Rosalba, Barlati, Stefano, Zanardi, Raffaella, Rosso, Gianluca, Di Nicola, Marco, Andriola, Ileana, Marcatili, Matteo, Clerici, Massimo, Dell'Osso, Bernardo Maria, Sensi, Stefano L., Mansur, Rodrigo B., Rosenblat, Joshua D., Martinotti, Giovanni, and McIntyre, Roger S.

Published
2024
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