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Your search keyword '"Mcintyre, Maggie S"' showing total 7 results
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7 results on '"Mcintyre, Maggie S"'

2. Discovery of a Highly Potent, Nonabsorbable Apical Sodium-Dependent Bile Acid Transporter Inhibitor (GSK2330672) for Treatment of Type 2 Diabetes

Author

Wu, Yulin, primary, Aquino, Christopher J., additional, Cowan, David J., additional, Anderson, Don L., additional, Ambroso, Jeff L., additional, Bishop, Michael J., additional, Boros, Eric E., additional, Chen, Lihong, additional, Cunningham, Alan, additional, Dobbins, Robert L., additional, Feldman, Paul L., additional, Harston, Lindsey T., additional, Kaldor, Istvan W., additional, Klein, Ryan, additional, Liang, Xi, additional, McIntyre, Maggie S., additional, Merrill, Christine L., additional, Patterson, Kristin M., additional, Prescott, Judith S., additional, Ray, John S., additional, Roller, Shane G., additional, Yao, Xiaozhou, additional, Young, Andrew, additional, Yuen, Josephine, additional, and Collins, Jon L., additional

Published
2013
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3. Novel 4,4-Disubstituted Piperidine-Based C–C Chemokine Receptor-5 Inhibitors with High Potency against Human Immunodeficiency Virus-1 and an Improved human Ether-a-go-go Related Gene (hERG) Profile

Author

Kazmierski, Wieslaw M., primary, Anderson, Don L., additional, Aquino, Christopher, additional, Chauder, Brian A., additional, Duan, Maosheng, additional, Ferris, Robert, additional, Kenakin, Terrence, additional, Koble, Cecilia S., additional, Lang, Dan G., additional, Mcintyre, Maggie S, additional, Peckham, Jennifer, additional, Watson, Christian, additional, Wheelan, Pat, additional, Spaltenstein, Andrew, additional, Wire, Mary B., additional, Svolto, Angilique, additional, and Youngman, Michael, additional

Published
2011
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4. 6-(4-Chlorophenyl)-3-substituted-thieno[3,2-d]pyrimidin-4(3H)-one-Based Melanin-Concentrating Hormone Receptor 1 Antagonist

Author

Tavares, Francis X., primary, Al-Barazanji, Kamal A., additional, Bishop, Michael J., additional, Britt, Christy S., additional, Carlton, David L., additional, Cooper, Joel P., additional, Feldman, Paul L., additional, Garrido, Dulce M., additional, Goetz, Aaron S., additional, Grizzle, Mary K., additional, Hertzog, Donald L., additional, Ignar, Diane M., additional, Lang, Daniel G., additional, McIntyre, Maggie S., additional, Ott, Ronda J., additional, Peat, Andrew J., additional, and Zhou, Hui-Qiang, additional

Published
2006
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5. Identification and Structure–Activity Studies of Novel Ultrashort-Acting Benzodiazepine Receptor Agonists

Author

Stafford,, Jeffrey A., primary, Pacofsky,, Gregory J., additional, Cox, Richard F., additional, Cowan, Jill R., additional, Dorsey, George F., additional, Gonzales, Stephen S., additional, Jung, David K., additional, Koszalka, George W., additional, McIntyre, Maggie S., additional, Tidwell, Jeffrey H., additional, Wiard, Robert P., additional, and Feldman, Paul L., additional

Published
2002
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6. Relating the Structure, Activity, and Physical Properties of Ultrashort-Acting Benzodiazepine Receptor Agonists

Author

Pacofsky, Gregory J., primary, Stafford, Jeffrey A., additional, Cox, Richard F., additional, Cowan, Jill R., additional, Dorsey, George F., additional, Gonzales, Stephen S., additional, Kaldor, Istvan, additional, Koszalka, George W., additional, Lovell, George G., additional, McIntyre, Maggie S., additional, Tidwell, Jeffrey H., additional, Todd, Dan, additional, Whitesell, Graham, additional, Wiard, Robert P., additional, and Feldman, Paul L., additional

Published
2002
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7. Propranolol inhibits the human ether-a-go-go-related gene potassium channels

Author

Xiaozhou Yao, McIntyre, Maggie S., Lang, Daniel G., Song, Ivy H., Becherer, James D., and Hashim, Mir A.

Subjects
*ORGANIC compounds, *POTASSIUM channels, *MENTAL health, *ION channels
Abstract

Abstract: Propranolol is a noncardioselective beta-adrenergic antagonist that has been recently reported to prolong the QTc interval on the surface electrocardiogram in humans when overdosed [Farhangi, V., Sansone, R.A. (2003). QTc prolongation due to propranolol overdose. Int. J. Psychiatry Med. 33, 201−202.]. To examine the underlying mechanisms for these clinical findings, we studied the effects of propranolol on the human cardiac potassium channels encoded by the ether-a-go-go-related gene (ERG) using the whole cell voltage-clamp technique. We found that propranolol blocked hERG currents in a concentration-dependent manner with an IC50 of 9.9±1.3 μM which is relevant to the predicted plasma level of propranolol in this case report. The present study demonstrated that propranolol can inhibit hERG channels. The interaction between propranolol and hERG channels could lead to delayed cardiac repolarization and might be a molecular mechanism for the previously reported QTc prolongation when propranolol is overdosed. [Copyright &y& Elsevier]

Published
2005
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