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Linear bis- and tris-onium ethers (I and II) have weak tubocurarine-like properties. In both series, potency increased with increase in alkyl group size. No evidence was found for a one point receptor attachment in bis-onium ethers

The tris-onium ethers (XIII, A and B) and the tetra-onium ethers (XV A, B and C), together with the corresponding polymethylene tris-onium (XIV A and B) and polymethylene tetra-onium compounds (XVI, A, B and C), have been synthesised. Replacement of a methylene group in the inter-onium polymethylene chain by an ether link almost always lowers muscle relaxant potency.