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1. Sleep characteristics and cardio-metabolic comorbidities in the OSA-COPD overlap syndrome: Data from the European Sleep Apnea Database (ESADA)

Author: van Zeller, M, primary, K. Basoglu, O, additional, Verbraecken, J, additional, Lombardi, C, additional, T. Mcnicholas, W, additional, Pepin, J L, additional, Steiropoulos, P, additional, Sliwinski, P, additional, Correia, D, additional, R. Bonsignore, M, additional, E. Schiza, S, additional, Hedner, J, additional, Grote, L, additional, and Drummond, M, additional
Published: 2022
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2. Obstructive sleep apnoea in adult patients post-tonsillectomy

Author: Riha, R, Kotoulas, S, Pataka, A, Kvamme, J, Joppa, P, Hedner, J, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Grote, L, Kent, B, Lena, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pepin, J, Plywaczewski, R, Pretl, M, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Sliwinski, P, Staats, R, Steiropoulos, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, Riha R. L., Kotoulas S. -. C., Pataka A., Kvamme J. A., Joppa P., Hedner J., Anttalainen U., Barbe F., Bonsignore M. R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Grote L., Kent B. D., Lena L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., McNicholas W. T., Montserrat J. M., Parati G., Penzel T., Pepin J. L., Plywaczewski R., Pretl M., Rodenstein D., Roisman G., Ryan S., Saaresranta T., Schiza S. E., Schulz R., Sliwinski P., Staats R., Steiropoulos P., Tasbakan M. S., Tkacova R., Varoneckas G., Verbraecken J., Vitols A., Vrints H., Zielinski J., Riha, R, Kotoulas, S, Pataka, A, Kvamme, J, Joppa, P, Hedner, J, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Grote, L, Kent, B, Lena, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pepin, J, Plywaczewski, R, Pretl, M, Rodenstein, D, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Sliwinski, P, Staats, R, Steiropoulos, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vitols, A, Vrints, H, Zielinski, J, Riha R. L., Kotoulas S. -. C., Pataka A., Kvamme J. A., Joppa P., Hedner J., Anttalainen U., Barbe F., Bonsignore M. R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Grote L., Kent B. D., Lena L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., McNicholas W. T., Montserrat J. M., Parati G., Penzel T., Pepin J. L., Plywaczewski R., Pretl M., Rodenstein D., Roisman G., Ryan S., Saaresranta T., Schiza S. E., Schulz R., Sliwinski P., Staats R., Steiropoulos P., Tasbakan M. S., Tkacova R., Varoneckas G., Verbraecken J., Vitols A., Vrints H., and Zielinski J.
Abstract: Background: The impact of removing the upper airway lymphoid tissue and in particular, tonsillectomy, in adults with OSA has not been demonstrated in large populations. Aims: To compare the severity of OSA and the prevalence of cardiovascular, metabolic and respiratory co-morbidities between patients with OSA who had undergone previous tonsillectomy and those who had not. Methods: The 19,711 participants in this study came from the European sleep apnea database (ESADA) which comprises data from unselected adult patients aged 18–80 years with a history of symptoms suggestive of OSA referred to sleep centers throughout Europe. Results: There were no differences between the two groups in terms of sex ratio and age (146 patients with previous tonsillectomy vs. 19565 patients without). Patients who had undergone tonsillectomy had a lower body mass index (29.3 ± 5.2 kg/m2 vs 32.2 ± 6.6 kg/m2, p < 0.001), lower subjective sleep latency (17.1 ± 17.8 min vs 25.5 ± 30.4 min, p = 0.001), lower ODI (15.7 ± 18.3 events/hour vs 30.7 ± 26.1 events/hour, p < 0.001), and SpO2<90% time during sleep (21.8 ± 47.5 min vs 52.6 ± 80.8 min, p < 0.001). OSA patients with tonsillectomy had a lower prevalence of Type II diabetes mellitus (p = 0.001), hypertension (p < 0.001) and a higher prevalence of hyperlipidemia (p < 0.001) and were less likely to be commenced on CPAP (p < 0.001). Conclusion: In a large population of almost 20,000 OSA patients from across Europe, patients who had undergone tonsillectomy presented with less severe OSA at time of diagnosis, and had a lower prevalence of Type II diabetes mellitus and cardiovascular co-morbidities.
Published: 2021

3. The effects of various pharmacological treatments on sleep

Author: Bassetti, C L, Paunino, T, McNicholas, W, Bassetti, C L ( C L ), Paunino, T ( T ), McNicholas, W ( W ), Landolt, Hans-Peter; https://orcid.org/0000-0003-0887-9403, Werth, Esther, Bassetti, C L, Paunino, T, McNicholas, W, Bassetti, C L ( C L ), Paunino, T ( T ), McNicholas, W ( W ), Landolt, Hans-Peter; https://orcid.org/0000-0003-0887-9403, and Werth, Esther
Published: 2021

4. Sleep apnoea management in Europe during the COVID-19 pandemic – Data from the European Sleep Apnoea Database (ESADA)

Author: Grote, L, Mcnicholas, W, Hedner, J, Anttalainen, U, Saaresranta, T, Basoglu, O, Gunduz, C, Tasbakan, S, Bouloukaki, I, Schiza, S, Bonsignore, M, Marrone, O, Petitjean, M, Roisman, G, Fietze, I, Laharnar, N, Penzel, T, Zou, D, Kent, B, Ryan, S, Kvamme, J, Bailly, S, Pepin, J, Tamisier, R, Lombardi, C, Parati, G, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Joppa, P, Verbraecken, J, Petiet, E, Trakada, G, Ludka, O, Buskova, J, Hein, H, Drummond, M, van Zeller, M, Dogas, Z, Galic, T, Gouveris, H, Mihaicuta, S, Randerath, W, Herkenrath, S, Fanfulla, F, Testelmans, D, Grote L., McNicholas W. T., Hedner J., Anttalainen U., Saaresranta T., Basoglu O. K., Gunduz C., Tasbakan S., Bouloukaki I., Schiza S. E., Bonsignore M. R., Marrone O., Petitjean M., Roisman G., Fietze I., Laharnar N., Penzel T., Zou D., Kent B. D., Ryan S., Kvamme J. A., Bailly S., Pepin J. -L., Tamisier R., Lombardi C., Parati G., Pataka A., Plywaczewski R., Sliwinski P., Pretl M., Riha R., Staats R., Steiropoulos P., Joppa P., Verbraecken J., Petiet E., Trakada G., Ludka O., Buskova J., Hein H., Drummond M., van Zeller M., Dogas Z., Galic T., Gouveris H., Mihaicuta S., Randerath W., Herkenrath S., Fanfulla F., Testelmans D., Grote, L, Mcnicholas, W, Hedner, J, Anttalainen, U, Saaresranta, T, Basoglu, O, Gunduz, C, Tasbakan, S, Bouloukaki, I, Schiza, S, Bonsignore, M, Marrone, O, Petitjean, M, Roisman, G, Fietze, I, Laharnar, N, Penzel, T, Zou, D, Kent, B, Ryan, S, Kvamme, J, Bailly, S, Pepin, J, Tamisier, R, Lombardi, C, Parati, G, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Staats, R, Steiropoulos, P, Joppa, P, Verbraecken, J, Petiet, E, Trakada, G, Ludka, O, Buskova, J, Hein, H, Drummond, M, van Zeller, M, Dogas, Z, Galic, T, Gouveris, H, Mihaicuta, S, Randerath, W, Herkenrath, S, Fanfulla, F, Testelmans, D, Grote L., McNicholas W. T., Hedner J., Anttalainen U., Saaresranta T., Basoglu O. K., Gunduz C., Tasbakan S., Bouloukaki I., Schiza S. E., Bonsignore M. R., Marrone O., Petitjean M., Roisman G., Fietze I., Laharnar N., Penzel T., Zou D., Kent B. D., Ryan S., Kvamme J. A., Bailly S., Pepin J. -L., Tamisier R., Lombardi C., Parati G., Pataka A., Plywaczewski R., Sliwinski P., Pretl M., Riha R., Staats R., Steiropoulos P., Joppa P., Verbraecken J., Petiet E., Trakada G., Ludka O., Buskova J., Hein H., Drummond M., van Zeller M., Dogas Z., Galic T., Gouveris H., Mihaicuta S., Randerath W., Herkenrath S., Fanfulla F., and Testelmans D.
Published: 2020

5. Long-term positive airway pressure therapy is associated with reduced total cholesterol levels in patients with obstructive sleep apnea: data from the European Sleep Apnea Database (ESADA)

Author: Gunduz, C, Basoglu, O, Kvamme, J, Verbraecken, J, Anttalainen, U, Marrone, O, Steiropoulos, P, Roisman, G, Joppa, P, Hein, H, Trakada, G, Hedner, J, Grote, L, Petiet, E, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Tkacova, R, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Pataka, A, Saaresranta, T, Plywaczewski, R, Sliwinski, P, Bielicki, P, Gunduz C., Basoglu O. K., Kvamme J. A., Verbraecken J., Anttalainen U., Marrone O., Steiropoulos P., Roisman G., Joppa P., Hein H., Trakada G., Hedner J., Grote L., Petiet E., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Tkacova R., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Pataka A., Saaresranta T., Plywaczewski R., Sliwinski P., Bielicki P., Gunduz, C, Basoglu, O, Kvamme, J, Verbraecken, J, Anttalainen, U, Marrone, O, Steiropoulos, P, Roisman, G, Joppa, P, Hein, H, Trakada, G, Hedner, J, Grote, L, Petiet, E, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Tkacova, R, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Pataka, A, Saaresranta, T, Plywaczewski, R, Sliwinski, P, Bielicki, P, Gunduz C., Basoglu O. K., Kvamme J. A., Verbraecken J., Anttalainen U., Marrone O., Steiropoulos P., Roisman G., Joppa P., Hein H., Trakada G., Hedner J., Grote L., Petiet E., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Tkacova R., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Pataka A., Saaresranta T., Plywaczewski R., Sliwinski P., and Bielicki P.
Abstract: Background and aim: Obstructive sleep apnea (OSA) is an independent risk factor for dyslipidemia. The current study examined the effects of positive airway pressure (PAP) treatment on lipid status in the European Sleep Apnea Database (ESADA). Methods: The prospective cohort study enrolled 1564 OSA subjects (74% male, mean age 54 ± 11y, body mass index (BMI) 32.7 ± 6.6 kg/m2 and apnea-hypopnea index (AHI) 40.3 ± 24.4 n/h) undergoing PAP therapy for at least three months (mean 377.6 ± 419.5 days). Baseline and follow-up total cholesterol (TC) from nine centers were analyzed. Repeated measures and logistic regression tests (adjusted for age, sex, weight changes, lipid lowering medication, PAP compliance, and treatment duration) were used to compare changes in TC concentration. Incident risk for a coronary heart disease event (CHD) was used to compute a Framingham CHD risk score (estimated from age, BMI, blood pressure, and TC). Results: Adjusted means of TC decreased from 194.2 mg/dl to 189.3 mg/dl during follow-up (p = 0.019). A clinically significant (10%) reduction of TC at PAP follow-up was observed in 422 patients (27%). Duration of PAP therapy was identified as independent predictor for TC reduction, which implies an approximately 10% risk reduction for incident CHD events (from 26.7% to 24.1% in men and from 11.2% to 10.1% in women, p < 0.001 respectively). Conclusion: This observational study demonstrates a reduction of TC after long-term PAP treatment. The close association between TC concentration and cardiovascular (CV) mortality suggests that identification and treatment of OSA may have a beneficial effect on overall CV risk due to this mechanism. This possibility needs to be evaluated in prospective randomized studies.
Published: 2020

6. Mild obstructive sleep apnea increases hypertension risk, challenging traditional severity classification

Author: Bouloukaki, I, Grote, L, Mcnicholas, W, Hedner, J, Verbraecken, J, Parati, G, Lombardi, C, Basoglu, O, Pataka, A, Marrone, O, Steiropoulos, P, Bonsignore, M, Schiza, S, Bouloukaki I., Grote L., McNicholas W. T., Hedner J., Verbraecken J., Parati G., Lombardi C., Basoglu O. K., Pataka A., Marrone O., Steiropoulos P., Bonsignore M. R., Schiza S. E., Bouloukaki, I, Grote, L, Mcnicholas, W, Hedner, J, Verbraecken, J, Parati, G, Lombardi, C, Basoglu, O, Pataka, A, Marrone, O, Steiropoulos, P, Bonsignore, M, Schiza, S, Bouloukaki I., Grote L., McNicholas W. T., Hedner J., Verbraecken J., Parati G., Lombardi C., Basoglu O. K., Pataka A., Marrone O., Steiropoulos P., Bonsignore M. R., and Schiza S. E.
Abstract: Study Objectives: The association of mild obstructive sleep apnea (OSA) with important clinical outcomes remains unclear. We aimed to investigate the association between mild OSA and systemic arterial hypertension (SAH) in the European Sleep Apnea Database cohort. Methods: In a multicenter sample of 4,732 participants, we analyzed the risk of mild OSA (subclassified into 2 groups: MildAHI 5-<11/h (apnea-hypopnea index [AHI], 5 to <11 events/h) and mildAHI 11-<15/h (AHI, .11 to <15 events/h) compared with nonapneic snorers for prevalent SAH after adjustment for relevant confounding factors including sex, age, smoking, obesity, daytime sleepiness, dyslipidemia, chronic obstructive pulmonary disease, type 2 diabetes, and sleep test methodology (polygraphy or polysomnography). Results: SAH prevalence was higher in the mildAHI 11-<15/h OSA group compared with the mildAHI 5-<11/h group and nonapneic snorers (52% vs 45% vs 30%; P < -001). Corresponding adjusted odds ratios for SAH were 1.789 (mildAHI 11-<15/h; 95% confidence interval [CI], 1.49.2.15) and 1.558 (mildAHI 5-<11/h; 95%, CI, 1.34.1.82), respectively (P <.001). In sensitivity analysis, mildAHI 11-<15/h OSA remained a significant predictor for SAH both in the polygraphy (odds ratio, 1.779; 95% CI, 1.403.2.256; P < -001) and polysomnography groups (odds ratio, 1.424; 95% CI, 1.047.1.939; P = .025). Conclusions: Our data suggest a dose-response relationship betweenmild OSA and SAH risk, starting from 5 events/h in polygraphy recordings and continuing with a further risk increase in the 11-to <150-events/h range. These findings potentially introduce a challenge to traditional thresholds of OSA severity and may help to stratify participants with OSA according to cardiovascular risk.
Published: 2020

7. Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database

Author: Lombardi, C, Parati, G, Soranna, D, Zambon, A, Sliwinski, P, Roisman, G, Pepin, J, Schiza, S, Riha, R, Joppa, P, Fietze, I, Hedner, J, Grote, L, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Dogas, Z, Dorkova, Z, Escourrou, P, Hein, H, Kvamme, J, Levy, P, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Pataka, A, Penzel, T, Petiet, E, Plywaczewski, R, Pretl, M, Ryan, S, Saaresranta, T, Schulz, R, Tasbakan, M, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Lombardi C., Parati G., Soranna D., Zambon A., Sliwinski P., Roisman G., Pepin J. -L., Schiza S., Riha R., Joppa P., Fietze I., Hedner J., Grote L., Anttalainen U., Barbe F., Bonsignore M. R., Basoglu O. K., Bielicki P., Dogas Z., Dorkova Z., Escourrou P., Hein H., Kvamme J. A., Levy P., Marrone O., Masa J. F., McNicholas W. T., Montserrat J. M., Pataka A., Penzel T., Petiet E., Pepin J. L., Plywaczewski R., Pretl M., Riha R. L., Ryan S., Saaresranta T., Schulz R., Tasbakan M. S., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Verbraecken J., Lombardi, C, Parati, G, Soranna, D, Zambon, A, Sliwinski, P, Roisman, G, Pepin, J, Schiza, S, Riha, R, Joppa, P, Fietze, I, Hedner, J, Grote, L, Anttalainen, U, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Dogas, Z, Dorkova, Z, Escourrou, P, Hein, H, Kvamme, J, Levy, P, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Pataka, A, Penzel, T, Petiet, E, Plywaczewski, R, Pretl, M, Ryan, S, Saaresranta, T, Schulz, R, Tasbakan, M, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Lombardi C., Parati G., Soranna D., Zambon A., Sliwinski P., Roisman G., Pepin J. -L., Schiza S., Riha R., Joppa P., Fietze I., Hedner J., Grote L., Anttalainen U., Barbe F., Bonsignore M. R., Basoglu O. K., Bielicki P., Dogas Z., Dorkova Z., Escourrou P., Hein H., Kvamme J. A., Levy P., Marrone O., Masa J. F., McNicholas W. T., Montserrat J. M., Pataka A., Penzel T., Petiet E., Pepin J. L., Plywaczewski R., Pretl M., Riha R. L., Ryan S., Saaresranta T., Schulz R., Tasbakan M. S., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., and Verbraecken J.
Abstract: Background and objective: OSA and PLMS are known to induce acute BP swings during sleep. Our current study aimed to address the independent effect of PLMS on BP in an unselected OSA patient cohort. Methods: This cross-sectional analysis included 1487 patients (1110 males, no previous hypertension diagnosis or treatment, mean age: 52.5 years, mean BMI: 30.5 kg/m2) with significant OSA (defined as AHI ≥ 10) recruited from the European Sleep Apnoea Cohort. Patients underwent overnight PSG. Patients were stratified into two groups: patients with significant PLMS (PLMSI > 25 events/hour of sleep) and patients without significant PLMS (PLMSI < 25 events/hour of sleep). SBP, DBP and PP were the variables of interest. For each of these, a multivariate regression linear model was fitted to evaluate the relationship between PLMS and outcome adjusting for sociodemographic and clinical covariates (gender, age, BMI, AHI, ESS, diabetes, smoking and sleep efficiency). Results: The univariate analysis of SBP showed an increment of BP equal to 4.70 mm Hg (P < 0.001) in patients with significant PLMS compared to patients without significant PLMS. This increment remained significant after implementing a multivariate regression model (2.64 mm Hg, P = 0.044). No significant increment of BP was observed for DBP and PP. Conclusion: PLMS is associated with a rise in SBP regardless of AHI, independent of clinical and sociodemographic confounders. A PLMS phenotype may carry an increased risk for cardiovascular disease in OSA patients.
Published: 2020

8. Activity of Dorsal Medullary Respiratory Neurons in Awake Rats

Author: Martial, F. P., Dunleavy, M., Jones, J. F. X., Nolan, P., O’Regan, R. G., McNicholas, W., Bradford, A., Pequignot, Jean-Marc, editor, Gonzalez, Constancio, editor, Nurse, Colin A., editor, Prabhakar, Nanduri R., editor, and Dalmaz, Yvette, editor
Published: 2003
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9. Comment to the editorial by KS Park and EW Kang “Is only fixed positive airway pressure a robust tool for kidney protection in patients with obstructive sleep apnea?”

Author: Marrone, O, Cibella, F, Pepin, J, Grote, L, Verbraecken, J, Saaresranta, T, Kvamme, J, Basoglu, O, Lombardi, C, Mcnicholas, W, Hedner, J, Bonsignore, M, Marrone O., Cibella F., Pepin J. -L., Grote L., Verbraecken J., Saaresranta T., Kvamme J. A., Basoglu O. K., Lombardi C., McNicholas W. T., Hedner J., Bonsignore M. R., Marrone, O, Cibella, F, Pepin, J, Grote, L, Verbraecken, J, Saaresranta, T, Kvamme, J, Basoglu, O, Lombardi, C, Mcnicholas, W, Hedner, J, Bonsignore, M, Marrone O., Cibella F., Pepin J. -L., Grote L., Verbraecken J., Saaresranta T., Kvamme J. A., Basoglu O. K., Lombardi C., McNicholas W. T., Hedner J., and Bonsignore M. R.
Published: 2019

10. Use of the Clinical Global Impression scale in sleep apnea patients – Results from the ESADA database

Author: Dieltjens, M, Verbraecken, J, Hedner, J, Vanderveken, O, Steiropoulos, P, Kvamme, J, Saaresranta, T, Tkacova, R, Marrone, O, Dogas, Z, Schiza, S, Grote, L, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Hein, H, Basoglu, O, Tasbakan, M, Varoneckas, G, Joppa, P, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Escourrou, P, Roisman, G, Pretl, M, Vitols, A, Galic, T, Pataka, A, Anttalainen, U, Sliwinski, P, Plywaczewski, R, Bielicki, P, Zielinski, J, Dieltjens M., Verbraecken J. A., Hedner J., Vanderveken O. M., Steiropoulos P., Kvamme J. A., Saaresranta T., Tkacova R., Marrone O., Dogas Z., Schiza S., Grote L., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Hein H., Basoglu O. K., Tasbakan M. S., Varoneckas G., Joppa P., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Escourrou P., Roisman G., Pretl M., Vitols A., Galic T., Pataka A., Anttalainen U., Sliwinski P., Plywaczewski R., Bielicki P., Zielinski J., Dieltjens, M, Verbraecken, J, Hedner, J, Vanderveken, O, Steiropoulos, P, Kvamme, J, Saaresranta, T, Tkacova, R, Marrone, O, Dogas, Z, Schiza, S, Grote, L, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Ludka, O, Rodenstein, D, Masa, J, Bouloukaki, I, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Schulz, R, Zou, D, Pepin, J, Levy, P, Bailly, S, Lavie, L, Lavie, P, Hein, H, Basoglu, O, Tasbakan, M, Varoneckas, G, Joppa, P, Staats, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Bonsignore, M, Escourrou, P, Roisman, G, Pretl, M, Vitols, A, Galic, T, Pataka, A, Anttalainen, U, Sliwinski, P, Plywaczewski, R, Bielicki, P, Zielinski, J, Dieltjens M., Verbraecken J. A., Hedner J., Vanderveken O. M., Steiropoulos P., Kvamme J. A., Saaresranta T., Tkacova R., Marrone O., Dogas Z., Schiza S., Grote L., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Ludka O., Rodenstein D., Masa J. F., Bouloukaki I., Kent B., McNicholas W. T., Ryan S., Riha R. L., Schulz R., Zou D., Pepin J. L., Levy P., Bailly S., Lavie L., Lavie P., Hein H., Basoglu O. K., Tasbakan M. S., Varoneckas G., Joppa P., Staats R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Bonsignore M. R., Escourrou P., Roisman G., Pretl M., Vitols A., Galic T., Pataka A., Anttalainen U., Sliwinski P., Plywaczewski R., Bielicki P., and Zielinski J.
Abstract: Objective/Background: The Clinical Global Impression scale (CGI) reflects the clinician's assessment of the disease impact on patient's global functioning. We assessed predictors of CGI scale rating in patients with obstructive sleep apnea (OSA). Patients/Methods: Consecutive patients with suspected OSA (n = 7581) were identified in the European Sleep Apnea Database (ESADA). Anthropometrics, comorbidities, apnea severity obtained by polygraphy or polysomnography, and daytime sleepiness [Epworth Sleepiness Scale (ESS)] were assessed. The CGI 7-point scale was completed at the end of the diagnostic process (CGI-severity, ie, CGI-S) and, in a subpopulation, at treatment follow-up (CGI-Improvement). Results: CGI-S was rated mild to moderate in 44% of patients. CGI rating at any given apnea intensity was worse in women than in men (p < 0.01). Patients undergoing polygraphy (n = 5075) were more frequently rated as severely ill compared to those studied with polysomnography (19.0% vs 13.0%, p < 0.001). In patients aged ≤65 years, CGI scoring was generally better than in the elderly despite a similar degree of OSA (eg, ‘normal, not ill’ 24.2% vs 15.3%, p < 0.01, respectively). Independent predictors of CGI rating included age, BMI, AHI, ESS, cardio-metabolic comorbidities, and diagnosis based on polygraphy. CGI-improvement rating (Beta = −0.406, p < 0.01) was superior to sleep apnea severity or ESS-score (Beta = 0.052 and −0.021, p = 0.154 and 0.538 respectively) at baseline for prediction of good CPAP compliance at follow-up. Conclusions: CGI rating is confounded by gender, age class and the type of sleep diagnostic method. As OSA phenotypes differ, CGI may contribute as a clinical tool to reflect the significance of clinical disease.
Published: 2019

11. Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA)

Author: Gunduz, C, Basoglu, O, Hedner, J, Bonsignore, M, Hein, H, Staats, R, Bouloukaki, I, Roisman, G, Pataka, A, Sliwinski, P, Ludka, O, Pepin, J, Grote, L, Steiropoulos, P, Verbraecken, J, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Rodenstein, D, Masa, J, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Kvamme, J, Schulz, R, Zou, D, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Joppa, P, Tkacova, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Marrone, O, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Anttalainen, U, Saaresranta, T, Plywaczewski, R, Bielicki, P, Gunduz C., Basoglu O. K., Hedner J., Bonsignore M. R., Hein H., Staats R., Bouloukaki I., Roisman G., Pataka A., Sliwinski P., Ludka O., Pepin J. L., Grote L., Steiropoulos P., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Rodenstein D., Masa J. F., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Kvamme J. A., Schulz R., Zou D., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Joppa P., Tkacova R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Marrone O., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Anttalainen U., Saaresranta T., Plywaczewski R., Bielicki P., Gunduz, C, Basoglu, O, Hedner, J, Bonsignore, M, Hein, H, Staats, R, Bouloukaki, I, Roisman, G, Pataka, A, Sliwinski, P, Ludka, O, Pepin, J, Grote, L, Steiropoulos, P, Verbraecken, J, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Rodenstein, D, Masa, J, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Kvamme, J, Schulz, R, Zou, D, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Joppa, P, Tkacova, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Marrone, O, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Anttalainen, U, Saaresranta, T, Plywaczewski, R, Bielicki, P, Gunduz C., Basoglu O. K., Hedner J., Bonsignore M. R., Hein H., Staats R., Bouloukaki I., Roisman G., Pataka A., Sliwinski P., Ludka O., Pepin J. L., Grote L., Steiropoulos P., Verbraecken J., Petiet E., Trakada G., Montserrat J. M., Fietze I., Penzel T., Rodenstein D., Masa J. F., Schiza S., Kent B., McNicholas W. T., Ryan S., Riha R. L., Kvamme J. A., Schulz R., Zou D., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M. S., Varoneckas G., Joppa P., Tkacova R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Marrone O., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Anttalainen U., Saaresranta T., Plywaczewski R., and Bielicki P.
Abstract: Background and objective: Obstructive sleep apnoea (OSA) and hyperlipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and prevalence of hyperlipidaemia in patients of the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 11 892 patients (age 51.9 ± 12.5 years, 70% male, body mass index (BMI) 31.3 ± 6.6 kg/m2, mean oxygen desaturation index (ODI) 23.7 ± 25.5 events/h) investigated for OSA. The independent odds ratio (OR) for hyperlipidaemia in relation to measures of OSA (ODI, apnoea-hypopnoea index, mean and lowest oxygen saturation) was determined by means of general linear model analysis with adjustment for important confounders such as age, BMI, comorbidities and study site. Results: Hyperlipidaemia prevalence increased from 15.1% in subjects without OSA to 26.1% in those with severe OSA, P < 0.001. Corresponding numbers in patients with diabetes were 8.5% and 41.5%, P < 0.001. Compared with ODI quartile I, patients in ODI quartiles II-IV had an adjusted OR (95% CI) of 1.33 (1.15–1.55), 1.37 (1.17–1.61) and 1.33 (1.12–1.58) (P < 0.001), respectively, for hyperlipidaemia. Obesity was defined as a significant risk factor for hyperlipidaemia. Subgroups of OSA patients with cardio-metabolic comorbidities demonstrated higher prevalence of HL. In addition, differences in hyperlipidaemia prevalence were reported in European geographical regions with the highest prevalence in Central Europe. Conclusion: Obstructive sleep apnoea, in particular intermittent hypoxia, was independently associated with the prevalence of hyperlipidaemia diagnosis.
Published: 2019

12. Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA)

Author: Anttalainen, U, Grote, L, Fietze, I, Riha, R, Ryan, S, Staats, R, Hedner, J, Saaresranta, T, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Esquinas, C, Hayes, L, Joppa, P, Kurki, S, Kvamme, J, Tamisier, R, Lombardi, C, Marrone, O, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pepin, J, Pretl, M, Roisman, G, Schiza, S, Schulz, R, Sliwinski, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vrints, H, Anttalainen U., Grote L., Fietze I., Riha R. L., Ryan S., Staats R., Hedner J., Saaresranta T., Barbe F., Bonsignore M. R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Esquinas C., Hayes L., Joppa P., Kurki S., Kvamme J. A., Tamisier R., Lombardi C., Marrone O., McNicholas W. T., Montserrat J. M., Parati G., Pataka A., Penzel T., Pepin J. L., Pretl M., Roisman G., Schiza S. E., Schulz R., Sliwinski P., Tasbakan M. S., Tkacova R., Varoneckas G., Verbraecken J., Vrints H., Anttalainen, U, Grote, L, Fietze, I, Riha, R, Ryan, S, Staats, R, Hedner, J, Saaresranta, T, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Esquinas, C, Hayes, L, Joppa, P, Kurki, S, Kvamme, J, Tamisier, R, Lombardi, C, Marrone, O, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pepin, J, Pretl, M, Roisman, G, Schiza, S, Schulz, R, Sliwinski, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vrints, H, Anttalainen U., Grote L., Fietze I., Riha R. L., Ryan S., Staats R., Hedner J., Saaresranta T., Barbe F., Bonsignore M. R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Esquinas C., Hayes L., Joppa P., Kurki S., Kvamme J. A., Tamisier R., Lombardi C., Marrone O., McNicholas W. T., Montserrat J. M., Parati G., Pataka A., Penzel T., Pepin J. L., Pretl M., Roisman G., Schiza S. E., Schulz R., Sliwinski P., Tasbakan M. S., Tkacova R., Varoneckas G., Verbraecken J., and Vrints H.
Abstract: Purpose: The aim of the current study was to further investigate the concept of previously reported high occurrence of comorbidities in obstructive sleep patients (OSA) with insomnia-like symptoms. We hypothesized that this finding at least partly is mediated by nocturnal hypoxia. Moreover, we speculated that the spectrum of the clinical OSA phenotypes differs between European geographical regions. Methods: Cohort of the European Sleep Apnea Database (n = 17,325; 29.9% females) was divided into five subcohorts according to geographical region (North, East, South, West, Central) and further into four clinical presentation phenotypes based on daytime symptoms (EDS) and characteristics suggestive of insomnia. Results: The insomnia phenotype (alone or together with EDS) dominated in all European regions. Isolated insomnia, however, was less common in the West. Insomnia phenotype was associated with the highest proportion of cardiovascular comorbidity (51.7% in the insomnia vs. 43.9% in the EDS type). Measures of nocturnal hypoxemia were independently associated with cardiovascular comorbidity in phenotypes with insomnia-like symptoms. The burden of comorbidities was high across all geographical regions and clinical phenotypes. Regional differences were clinically relevant for age (48 vs. 54 years), BMI (29 vs. 34 kg/m2), and ODI (15 vs. 32/h). Conclusion: High prevalence of particularly cardiovascular comorbidity among patients with insomnia-like symptoms was linked to nocturnal hypoxemia. Considerable differences in clinical presentation were found among OSA patients across Europe. Our data underline that physicians should ask their patients with suspected OSA also for insomnia symptoms. It remains to be explored if a reduction of nocturnal hypoxemia predicts the improvement of insomnia symptoms.
Published: 2019

13. Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA)

Author: Anttalainen, Ulla, Grote, L., Fietze, I., Riha, R. L., Ryan, S., Staats, R., Hedner, J., Saaresranta, T., Anttalainen, U., Barbe, F., Bonsignore, M. R., Basoglu, O., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I, Esquinas, C., Hayes, L., Joppa, P., Kurki, S., Kvamme, J. A., Tamisier, R., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pepin, J. L., Pretl, M., Roisman, G., Schiza, S. E., Schulz, R., Sliwinski, P., Steiropoulos, P., Tasbakan, M. S., Tkacova, R., Varoneckas, G., Verbraecken, J., Vrints, H., Anttalainen, U, Grote, L, Fietze, I, Riha, R, Ryan, S, Staats, R, Hedner, J, Saaresranta, T, Barbe, F, Bonsignore, M, Basoglu, O, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Esquinas, C, Hayes, L, Joppa, P, Kurki, S, Kvamme, J, Tamisier, R, Lombardi, C, Marrone, O, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pepin, J, Pretl, M, Roisman, G, Schiza, S, Schulz, R, Sliwinski, P, Tasbakan, M, Tkacova, R, Varoneckas, G, Verbraecken, J, Vrints, H, Anttalainen U., Grote L., Fietze I., Riha R.L., Ryan S., Staats R., Hedner J., Saaresranta T., Barbe F., Bonsignore M.R., Basoglu O., Bielicki P., Bouloukaki I., Dogas Z., Dorkova Z., Escourrou P., Esquinas C., Hayes L., Joppa P., Kurki S., Kvamme J.A., Tamisier R., Lombardi C., Marrone O., McNicholas W.T., Montserrat J.M., Parati G., Pataka A., Penzel T., Pepin J.L., Pretl M., Roisman G., Schiza S.E., Schulz R., Sliwinski P., Tasbakan M.S., Tkacova R., Varoneckas G., Verbraecken J., Vrints H., Ege Üniversitesi, and ESADA Study Collaborators
Subjects: Adult, Male, medicine.medical_specialty, Insomnia, Neurology, Comorbidity, Settore MED/10 - Malattie Dell'Apparato Respiratorio, Nocturnal, Hypoxemia, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Sleep Initiation and Maintenance Disorders, Internal medicine, mental disorders, Prevalence, Humans, Medicine, Hypoxia, Sleep Apnea, Obstructive, business.industry, Sleep Breathing Physiology and Disorders • Original Article, Sleep apnea, Middle Aged, Cardiovascular disease, Phenotype, Hypoxia (medical), medicine.disease, Circadian Rhythm, nervous system diseases, Europe, 030228 respiratory system, Otorhinolaryngology, Cardiovascular Diseases, Cohort, Female, Human medicine, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: WOS: 000482433800011, PubMed ID: 30467691, Purpose The aim of the current study was to further investigate the concept of previously reported high occurrence of comorbidities in obstructive sleep patients (OSA) with insomnia-like symptoms. We hypothesized that this finding at least partly is mediated by nocturnal hypoxia. Moreover, we speculated that the spectrum of the clinical OSA phenotypes differs between European geographical regions. Methods Cohort of the European Sleep Apnea Database (n = 17,325; 29.9% females) was divided into five subcohorts according to geographical region (North, East, South, West, Central) and further into four clinical presentation phenotypes based on daytime symptoms (EDS) and characteristics suggestive of insomnia. Results The insomnia phenotype (alone or together with EDS) dominated in all European regions. Isolated insomnia, however, was less common in the West. Insomnia phenotype was associated with the highest proportion of cardiovascular comorbidity (51.7% in the insomnia vs. 43.9% in the EDS type). Measures of nocturnal hypoxemia were independently associated with cardiovascular comorbidity in phenotypes with insomnia-like symptoms. The burden of comorbidities was high across all geographical regions and clinical phenotypes. Regional differences were clinically relevant for age (48 vs. 54 years), BMI (29 vs. 34 kg/m(2)), and ODI (15 vs. 32/h). Conclusion High prevalence of particularly cardiovascular comorbidity among patients with insomnia-like symptoms was linked to nocturnal hypoxemia. Considerable differences in clinical presentation were found among OSA patients across Europe. Our data underline that physicians should ask their patients with suspected OSA also for insomnia symptoms. It remains to be explored if a reduction of nocturnal hypoxemia predicts the improvement of insomnia symptoms., European Union COST action B26; European Respiratory Society (ERS); ResMed Inc.; Philips Respironics Inc., The ESADA network has received support from the European Union COST action B26. The European Respiratory Society (ERS) supports the ESADA for the second period as a Clinical Research Collaboration (CRC) (2015-2017 and 2018-2020). Unrestricted seeding grants from ResMed Inc. and Philips Respironics Inc. for establishment of the organization and the database are gratefully acknowledged.
Published: 2018

14. Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database

Author: Gündüz, Canan, Basoglu, Ozen K., Hedner, Jan, Zou, Ding, Bonsignore, Maria R., Hein, Holger, Staats, Richard, Pataka, Athanasia, Barbe, Ferran, Sliwinski, Pavel, Kent, Brian D., Pepin, Jean Lois, Grote, Ludger, Anttalainen, U., Barbé, F., Bonsignore, M. R., Basoglu, O. K., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I., Grote, L., Hedner, J., Hein, H., Joppa, P., Kvamme, J. A., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schiza, S., Schulz, R., Sliwinski, P., Pepin, J. L., Petiet, Erna, Tasbakan, M. S., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Verbraecken, J., Vitols, A., Gündüz, C, Basoglu, O, Hedner, J, Zou, D, Bonsignore, M, Hein, H, Staats, R, Pataka, A, Barbe, F, Sliwinski, P, Kent, B, Pepin, J, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Joppa, P, Kvamme, J, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Petiet, E, Tasbakan, M, Tkacova, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Vitols, A, Gunduz, C, Hender, J, and Lepin, J
Subjects: Male, obesity, Databases, Factual, cholesterol, dyslipidemia, hypoxia, obesity, sleep apnoea, Gastroenterology, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Hypolipidemic Agents, Oxygen saturation (medicine), Sleep Apnea, Obstructive, medicine.diagnostic_test, Sleep apnea, Middle Aged, Europe, Quartile, Cardiovascular Diseases, Cohort, Female, lipids (amino acids, peptides, and proteins), Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, Internal medicine, medicine, Humans, Triglycerides, Dyslipidemias, hypoxia, Cholesterol, business.industry, Cholesterol, HDL, dyslipidemia, cholesterol, Cholesterol, LDL, ta3121, medicine.disease, Obesity, nervous system diseases, respiratory tract diseases, Cross-Sectional Studies, 030228 respiratory system, chemistry, Lipid profile, business, sleep apnoea, 030217 neurology & neurosurgery, Dyslipidemia
Abstract: Background and objective: Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 8592 patients without physician-diagnosed hyperlipidaemia or reported intake of a lipid-lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnoea–hypopnoea index (AHI): 25.7 ± 25.9 events/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profile (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and fasting triglycerides (TG)) was determined by means of general linear model analysis. Results: There was a dose response relationship between TC and ODI (mean ± SE (mg/dL): 180.33 ± 2.46, 184.59 ± 2.42, 185.44 ± 2.42 and 185.73 ± 2.44; P < 0.001 across ODI quartiles I–IV). TG and LDL concentrations were better predicted by AHI than by ODI. HDL-C was significantly reduced in the highest AHI quartile (mean ± SE (mg/dL): 48.8 ± 1.49 vs 46.50 ± 1.48; P = 0.002, AHI quartile I vs IV). Morbid obesity was associated with lower TC and higher HDL-C values. Lipid status was influenced by geographical location with the highest TC concentration recorded in Northern Europe. Conclusion: OSA severity was independently associated with cholesterol and TG concentrations.
Published: 2018

15. Reliability of the Turkish version of the European Obstructive Sleep Apnea Screening (EUROSAS) questionnaire for drivers

Author: Peker, Yüksel (ORCID 0000-0001-9067-6538 & YÖK ID 234103); Çelik, Yeliz, Özaydın, A. N.; Çetinkaya, R.; Kabadayı, E.; Karaküçük, A. G.; McNicholas, W. T., Peker, Yüksel (ORCID 0000-0001-9067-6538 & YÖK ID 234103); Çelik, Yeliz, and Özaydın, A. N.; Çetinkaya, R.; Kabadayı, E.; Karaküçük, A. G.; McNicholas, W. T.
Abstract: Purpose: the European Union Driver License Committee recently developed a questionnaire as a screening tool for obstructive sleep apnea (OSA) named the European Obstructive Sleep Apnea Screening (EUROSAS) questionnaire for drivers. We sought to address the reliability of the Turkish version of this questionnaire. Methods: the EUROSAS was translated into Turkish. Using a ""test-retest approach"", data were collected twice with a 15-day interval among 150 participants (50 professional male drivers [PMD], 50 non-professional male drivers [NPMD], and 50 non-professional female drivers [NPFD]). The EUROSAS score ranges between 2 and 25, with scores >= 10 suggesting the presence of OSA. Results: the median EUROSAS scores in the first test were 8.0 (interquartile range [IQR] 6.8-12.0) in PMD, 8.0 (IQR 6.0-11.0) in NPMD, and 5.0 (IQR 4.0-8.0) in NPFD (p< 0.001). Corresponding values in the retest were 9.5 (IQR 7.0-13.0), 8.0 (IQR 6.0-10.0), and 5.0 (IQR 4.0-8.0), respectively (p< 0.001). The EUROSAS score >= 10 was found among 34% in the first test and 50% in the retest in PMD (ns), 34% vs 24% in NPMD (ns), and 8% vs 16% in NPFD (ns). There was a positive correlation between the tests (r= 0.864,p< 0.001), and Cronbach's alpha value for the whole group was 0.477 (0.514 for PMD, 0.512 for NPMD, and 0.543 NPFD, respectively). Conclusions: the EUROSAS-Turkish version is easy to understand and is reproducible. However, the test-retest reliability level is poor among the Turkish drivers. Further validation of the questionnaire by objective sleep studies and fitness-to-drive testing is necessary.
Published: 2021

16. Irish thoracic society: Proceeds of annual scientific meeting held Friday & Saturday 8th & 9th November, 1996

Author: Coakley, R., O’Neill, S., Coakley, R., Glynn, P., O’Neill, S., Finlay, G. A., Russell, K. J., McMahon, K., D’Arcy, E. M., Masterson, J. B., Fitzgerald, M. X., O’Connor, C. M., O’Driscoll, L. R., Finlay, G. A., Fitzgerald, M. X., O’Connor, C. M., McGarvey, L. P. A., Forsythe, P., Heaney, L. G., MacMahon, J., Ennis, M., Leonard, C., Tormey, V., Burke, C. M., Poulter, L. W., Keatings, V. M., FitzGerald, M. X., Barnes, P. J., Harty, H. R., Corfield, D. R., Adams, L., Schwartzstein, R. M., Kiely, J. F., Buckley, A., Shiels, P., Deegan, P. C., Maurer, B., McNicholas, W. T., Dunlop, K. A., Martin, B., Riley, M., Shields, M. D., Glynn, P., Kilgallen, I., Coakley, R., O’Neill, S., McElvaney, N. G., Cervantes-Laurean, D., Wehr, N., Gabriele, K., Robinson, W., Moss, J., Levine, R. L., Urbach, V., Walsh, D., Harvey, B., McElroy, M. C., Pittet, J-F., Allen, L., Wiener-Kroonish, J., Dobbs, L. G., O’Donnell, D. M., McMahon, K. J., O’Connor, C., Fitzgerald, M. X., McGuirk, P., Mahon, B., Griffin, F., Mills, K. H. G., Murphy, R., Brijker, F., Mulloy, E., Cohen Tervaert, J. W., Walshe, J., O’Neill, S., McGarvey, L. P. A., Heaney, L. G., Lowry, R. C., Shepherd, D. R. T., MacMahon, J., Gamble, L. A., Carton, C., Memon, R., Winter, D., Chan, A., Aherne, T., O’Reilly, P., Harbison, J. A., McNicholas, W. T., O’Callaghan, S., Mulloy, E., Keane, M., McKenna, M., Woods, S., O’Neill, S., Lamon, A., Leonard, C., Faul, J., Murphy, M., Burke, C. M., Tormey, V., Riley, M., Porszasz, J., Engelen, M. P. K. J., Brundage, B., Wasserman, K., Sweeney, M., O’Regan, R. G., McLoughlin, P., Sweeney, M., Honner, V., Sinnott, B., O’Regan, R. G., McLoughlin, P., Kilgallen, I., O’Neill, S., McGrath, D. S., Kiely, J., Cryan, B., Bredin, C. P., McGrath, D. S., Shortt, C., Stack, M., Kelleher, N., Bredin, C. P., Russell, K. J., McRedmond, J., Mulkerji, N., Keatings, V., Fitzgerald, M. X., O’Connor, C. M., Boylan, G. M., McElroy, M. C., Dobbs, L. G., Forsythe, P., McGarvey, L. P. A., Cross, L. J. M., Ennis, M., Heaney, L. G., MacMahon, J., Davern, S., O’Connor, C. M., McDonnell, T. J., Kiely, J. L., Lawless, G., Cunningham, S., McNicholas, W. T., Lordan, J., Clancy, L., Manning, P., Plunkett, P., Donaghy, D., Kiely, J., McDonnell, T. J., Ben Musbah, F., Loftus, B. G., Ben Musbah, F., Loftus, B. G., Rutherford, R., Watson, S. N. E., Gilmartin, J. J., Henry, M., Mullins, G., Brennan, N., Kiely, J. L., Deegan, P. C., and McNicholas, W. T.
Published: 1998
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17. Medico-legal implications of sleep apnoea syndrome: Driving license regulations in Europe

Author: Alonderis, A., Barbé, F., Bonsignore, M., Calverley, P., De Backer, W., Diefenbach, K., Donic, V., Fanfulla, F., Fietze, I., Franklin, K., Grote, L., Hedner, J., Jennum, P., Krieger, J., Levy, P., McNicholas, W., Montserrat, J., Parati, G., Pascu, M., Penzel, T., Riha, R., Rodenstein, D., Sanna, A., Schulz, R., Sforza, E., Sliwinski, P., Tomori, Z., Tonnesen, P., Varoneckas, G., Zielinski, J., and Kostelidou, K.
Published: 2008
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18. The wake-up bus sleep study: falling asleep at the wheel in 19 European countries: P518

Author: Goncalves, M. A., Amici, R., Peigneux, P., Lucas, R., Åkerstedt, T., Cirignotta, F. C., Horne, J., Léger, D., McNicholas, W., Partinen, M., Santos, Téran J., and Grote, L.
Published: 2014

19. Metabolic effects of OSA: 223

Author: McNicholas, W.
Published: 2014

20. Hyperlipidaemia prevalence and cholesterol control in obstructive sleep apnoea: Data from the European sleep apnea database (ESADA)

Author: Gunduz, C., Basoglu, O. Kacmaz, Hedner, J., Bonsignore, M. R., Hein, H., Staats, R., Bouloukaki, I, Roisman, G., Pataka, A., Sliwinski, P., Ludka, O., Pepin, J. L., Grote, L., Steiropoulos, P., Verbraecken, Johan, Petiet, E., Trakada, G., Montserrat, J. M., Fietze, I, Penzel, T., Ondrej, L., Rodenstein, D., Masa, J. F., Schiza, S., Kent, B., McNicholas, W. T., Ryan, S., Riha, R. L., Kvamme, J. A., Schulz, R., Zou, D., Pepina, J. L., Levy, P., Bailly, S., Lavie, L., Lavie, P., Basoglu, O. K., Tasbakan, M. S., Varoneckas, G., Joppa, P., Tkacova, R., Barbe, F., Lombardi, C., Parati, G., Drummond, M., van Zeller, M., Marrone, O., Petitjean, M., Pretl, M., Vitols, A., Dogas, Z., Galic, T., Anttalainen, U., Saaresranta, T., Plywaczewski, R., Bielicki, P., Gunduz, C, Basoglu, O, Hedner, J, Bonsignore, M, Hein, H, Staats, R, Bouloukaki, I, Roisman, G, Pataka, A, Sliwinski, P, Ludka, O, Pepin, J, Grote, L, Steiropoulos, P, Verbraecken, J, Petiet, E, Trakada, G, Montserrat, J, Fietze, I, Penzel, T, Rodenstein, D, Masa, J, Schiza, S, Kent, B, Mcnicholas, W, Ryan, S, Riha, R, Kvamme, J, Schulz, R, Zou, D, Levy, P, Bailly, S, Lavie, L, Lavie, P, Tasbakan, M, Varoneckas, G, Joppa, P, Tkacova, R, Barbe, F, Lombardi, C, Parati, G, Drummond, M, van Zeller, M, Marrone, O, Petitjean, M, Pretl, M, Vitols, A, Dogas, Z, Galic, T, Anttalainen, U, Saaresranta, T, Plywaczewski, R, Bielicki, P, Tıp Fakültesi, Gunduz C., Basoglu O.K., Hedner J., Bonsignore M.R., Hein H., Staats R., Bouloukaki I., Roisman G., Pataka A., Sliwinski P., Ludka O., Pepin J.L., Grote L., Steiropoulos P., Verbraecken J., Petiet E., Trakada G., Montserrat J.M., Fietze I., Penzel T., Rodenstein D., Masa J.F., Schiza S., Kent B., McNicholas W.T., Ryan S., Riha R.L., Kvamme J.A., Schulz R., Zou D., Levy P., Bailly S., Lavie L., Lavie P., Tasbakan M.S., Varoneckas G., Joppa P., Tkacova R., Barbe F., Lombardi C., Parati G., Drummond M., van Zeller M., Marrone O., Petitjean M., Pretl M., Vitols A., Dogas Z., Galic T., Anttalainen U., Saaresranta T., Plywaczewski R., Bielicki P., SALAS, Danielle, Biruni University [Istanbul] (BU), Ege university, University of Gothenburg (GU), Sahlgrenska University Hospital [Gothenburg], Università degli studi di Palermo - University of Palermo, CNR-IBIM : National Research Council-Institute of Biomedicine and Molecular Immunology, St. Adolf-Stift Hospital [Reinbek, Germany] (SASH), Hospital de Santa Maria [Lisboa], University of Crete [Heraklion] (UOC), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), General Hospital of Thessaloniki George Papanikolaou, Institute of Tuberculosis and Lung Diseases [Warsaw, Poland] (ITLD), University Hospital Brno, St. Anne’s University Hospital [Brno], Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Universitaire [Grenoble] (CHU), European Sleep Apnoea Database collaborators: P Steiropoulos, J Verbraecken, E Petiet, G Trakada, J M Montserrat, I Fietze, T Penzel, D Rodenstein, J F Masa, S Schiza, B Kent, W T McNicholas, S Ryan, R L Riha, J A Kvamme, R Schulz, D Zou, J L Pépin, P Levy, S Bailly, L Lavie, P Lavie, M S Tasbakan, G Varoneckas, P Joppa, R Tkacova, F Barbé, C Lombardi, G Parati, M Drummond, M van Zeller, O Marrone, M Petitjean, M Pretl, A Vitols, Z Dogas, T Galic, U Anttalainen, T Saaresranta, R Plywaczewski, P Bielicki, and European Sleep Apnoea Database Col
Subjects: Male, 0301 basic medicine, [SDV]Life Sciences [q-bio], Polysomnography, Hyperlipidemias, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 030204 cardiovascular system & hematology, computer.software_genre, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Diabetes mellitus, Prevalence, Internal Medicine, Humans, Medicine, cholesterol, hyperlipidaemia, hypoxia, obesity, sleep apnoea, Obesity, Sleep Apnea, Obstructive, Database, business.industry, Confounding, Sleep apnea, Odds ratio, Middle Aged, medicine.disease, respiratory tract diseases, [SDV] Life Sciences [q-bio], Europe, Cross-Sectional Studies, 030104 developmental biology, Quartile, Cardiovascular Diseases, Cohort, Female, Human medicine, business, Body mass index, computer
Abstract: Gunduz C, Basoglu OK, Hedner J, et al; onbehalf of the European Sleep Apnoea Databasecollaborators (Biruni University; Ege University;Gothenburg University; Sahlgrenska UniversityHospital; University of Palermo; CNR Institute ofBiomedicine and Molecular Immunology; St. AdolfStift; Hospital de Santa Maria; University of Crete;Antoine-Beclere Hospital; G. PapanikolaouHospital; Institute of Tuberculosis and LungDiseases; University Hospital Brno; St. Ann’sUniversity Hospital; Universite ́ Grenoble Alpes)Hyperlipidaemia prevalence and cholesterolcontrol in obstructive sleep apnoea: Data from theEuropean sleep apnea database (ESADA).J InternMed2019;286: 676–688.Background and objective.Obstructive sleep apnoea(OSA) and hyperlipidaemia are independent riskfactors for cardiovascular disease. This studyinvestigates the association between OSA andprevalence of hyperlipidaemia in patients of theEuropean Sleep Apnea Database (ESADA) cohort.Methods.The cross-sectional analysis included11 892 patients (age 51.9 12.5 years, 70% male,body mass index (BMI) 31.3 6.6 kg/m2, meanoxygen desaturation index (ODI) 23.7 25.5events/h) investigated for OSA. The independentodds ratio (OR) for hyperlipidaemia in relation tomeasures of OSA (ODI, apnoea-hypopnoea index,mean and lowest oxygen saturation) was deter-mined by means of general linear model analysiswith adjustment for important confounders suchas age, BMI, comorbidities and study site.Results.Hyperlipidaemia prevalence increased from15.1% in subjects without OSA to 26.1% in thosewith severe OSA,P
Published: 2019

21. Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort

Author: Basoglu, O, Zou, D, Tasbakan, M, Hedner, J, Ryan, S, Verbraecken, J, Escourrou, P, Antalainen, U, Kvamme, J, Bonsignore, M, Schiza, S, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Dogas, Z, Fietze, I, Hein, H, Joppa, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pépin, J, Petiet, E, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Saaresranta, T, Schulz, R, Sliwinski, P, Pepin, J, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Basoglu, Ozen K., Zou, Ding, Tasbakan, Mehmet S., Hedner, Jan, Ryan, Silke, Verbraecken, Johan, Escourrou, Pierre, Antalainen, Ulla, Kvamme, John A., Bonsignore, Maria R., Schiza, Sofia, Grote, Ludger, Anttalainen, U., Barbé, F., Bielicki, P., Dogas, Z., Fietze, I., Hein, H., Joppa, P., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Petiet, E., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Pepin, J. L., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Vitols, A., Basoglu, O, Zou, D, Tasbakan, M, Hedner, J, Ryan, S, Verbraecken, J, Escourrou, P, Antalainen, U, Kvamme, J, Bonsignore, M, Schiza, S, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Dogas, Z, Fietze, I, Hein, H, Joppa, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pépin, J, Petiet, E, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Saaresranta, T, Schulz, R, Sliwinski, P, Pepin, J, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Basoglu, Ozen K., Zou, Ding, Tasbakan, Mehmet S., Hedner, Jan, Ryan, Silke, Verbraecken, Johan, Escourrou, Pierre, Antalainen, Ulla, Kvamme, John A., Bonsignore, Maria R., Schiza, Sofia, Grote, Ludger, Anttalainen, U., Barbé, F., Bielicki, P., Dogas, Z., Fietze, I., Hein, H., Joppa, P., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Petiet, E., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Pepin, J. L., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., and Vitols, A.
Abstract: The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1,415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m2, apnea–hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analysed. Overall, body mass index (0.0 [95% confidence interval, −0.1 to 0.2] kg/m2) and neck circumference (0.0 (95% confidence interval, −0.1 to 0.1] cm) were unchanged after positive airway pressure treatment compared with baseline (follow-up duration 1.1 ± 1.0 years and compliance 5.2 ± 2.1 hr per day). However, in non-obese (body mass index <30 kg/m2) patients, positive airway pressure treatment was associated with an increased body mass index and waist circumference (0.4 [0.3–0.5] kg/m2 and 0.8 [0.4–1.2] cm, respectively, all p < 0.05), and weight gain was significantly associated with higher positive airway pressure compliance and longer positive airway pressure treatment duration. In the obese subgroup, body mass index was reduced after positive airway pressure treatment (−0.3 [−0.5 to −0.1] kg/m2, p < 0.05) mainly in patients with a strong reduction in Epworth Sleepiness Scale. In conclusion, positive airway pressure therapy was not found to systematically change body mass index in the European Sleep Apnea Database cohort, but the response was heterogeneous. Our findings suggest that weight gain may be restricted to an obstructive sleep apnea phenotype without established obesity. Lifestyle intervention needs to be considered in both lean and obese patients with obstructive slee
Published: 2018

22. Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database

Author: Gündüz, C, Basoglu, O, Hedner, J, Zou, D, Bonsignore, M, Hein, H, Staats, R, Pataka, A, Barbe, F, Sliwinski, P, Kent, B, Pepin, J, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Joppa, P, Kvamme, J, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Petiet, E, Tasbakan, M, Tkacova, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Vitols, A, Gündüz, Canan, Basoglu, Ozen K., Hedner, Jan, Zou, Ding, Bonsignore, Maria R., Hein, Holger, Staats, Richard, Pataka, Athanasia, Barbe, Ferran, Sliwinski, Pavel, Kent, Brian D., Pepin, Jean Lois, Grote, Ludger, Anttalainen, U., Barbé, F., Bonsignore, M. R., Basoglu, O. K., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I., Grote, L., Hedner, J., Hein, H., Joppa, P., Kvamme, J. A., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schiza, S., Schulz, R., Sliwinski, P., Pepin, J. L., Petiet, Erna, Tasbakan, M. S., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Verbraecken, J., Vitols, A., Gündüz, C, Basoglu, O, Hedner, J, Zou, D, Bonsignore, M, Hein, H, Staats, R, Pataka, A, Barbe, F, Sliwinski, P, Kent, B, Pepin, J, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Bouloukaki, I, Dogas, Z, Dorkova, Z, Escourrou, P, Fietze, I, Joppa, P, Kvamme, J, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Penzel, T, Pépin, J, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Ryan, S, Saaresranta, T, Schiza, S, Schulz, R, Petiet, E, Tasbakan, M, Tkacova, R, Steiropoulos, P, Varoneckas, G, Verbraecken, J, Vitols, A, Gündüz, Canan, Basoglu, Ozen K., Hedner, Jan, Zou, Ding, Bonsignore, Maria R., Hein, Holger, Staats, Richard, Pataka, Athanasia, Barbe, Ferran, Sliwinski, Pavel, Kent, Brian D., Pepin, Jean Lois, Grote, Ludger, Anttalainen, U., Barbé, F., Bonsignore, M. R., Basoglu, O. K., Bielicki, P., Bouloukaki, I., Dogas, Z., Dorkova, Z., Escourrou, P., Fietze, I., Grote, L., Hedner, J., Hein, H., Joppa, P., Kvamme, J. A., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schiza, S., Schulz, R., Sliwinski, P., Pepin, J. L., Petiet, Erna, Tasbakan, M. S., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Verbraecken, J., and Vitols, A.
Abstract: Background and objective: Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 8592 patients without physician-diagnosed hyperlipidaemia or reported intake of a lipid-lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnoea–hypopnoea index (AHI): 25.7 ± 25.9 events/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profile (total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and fasting triglycerides (TG)) was determined by means of general linear model analysis. Results: There was a dose response relationship between TC and ODI (mean ± SE (mg/dL): 180.33 ± 2.46, 184.59 ± 2.42, 185.44 ± 2.42 and 185.73 ± 2.44; P < 0.001 across ODI quartiles I–IV). TG and LDL concentrations were better predicted by AHI than by ODI. HDL-C was significantly reduced in the highest AHI quartile (mean ± SE (mg/dL): 48.8 ± 1.49 vs 46.50 ± 1.48; P = 0.002, AHI quartile I vs IV). Morbid obesity was associated with lower TC and higher HDL-C values. Lipid status was influenced by geographical location with the highest TC concentration recorded in Northern Europe. Conclusion: OSA severity was independently associated with cholesterol and TG concentrations.
Published: 2018

23. Sleep staging using cardiorespiratory signals

Author: Redmond, S. J., de Chazal, P., O'Brien, C., Ryan, S., McNicholas, W. T., and Heneghan, C.
Published: 2007
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24. EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke [guidelines]

Author: Bassetti, C. L. A., Randerath, W, Vignatelli, L, Ferini-Strambi, L, Brill, A.-K., Bonsignore, M R, Grote, L, Jennum, P, Leys, D, Minnerup, J, Nobili, L, Tonia, T., Morgan, R, Kerry, J, Riha, R, McNicholas, W T, and Papavasileiou, V
Subjects: mental disorders, cardiovascular diseases, 610 Medicine & health, 360 Social problems & social services
Abstract: BACKGROUND Sleep disorders are highly prevalent in the general population and may be linked in a bidirectional fashion to stroke, which is one of the leading causes of morbidity and mortality. AIM Four major scientific societies established a task force of experts in neurology, stroke, respiratory medicine, sleep medicine and methodology to critically evaluate the evidence regarding potential links and the impact of therapy. MATERIALS AND METHODS Thirteen research questions were evaluated in a systematic literature search using a stepwise hierarchical approach: first, systematic reviews and meta-analyses; second, primary studies post-dating the systematic reviews/meta-analyses. A total of 445 studies were evaluated and 88 were included. Statements were generated regarding current evidence and clinical practice. RESULTS Severe obstructive sleep apnoea (OSA) doubles the risk for incident stroke, especially in young to middle-aged patients. Continuous positive airway pressure (CPAP) may reduce stroke risk, especially in treatment-compliant patients. The prevalence of OSA is high in stroke patients and can be assessed by polygraphy. Severe OSA is a risk factor for recurrence of stroke and may be associated with stroke mortality, whilst CPAP may improve stroke outcome. It is not clear if insomnia increases stroke risk, whilst the pharmacotherapy of insomnia may increase it. Periodic limb movements in sleep (PLMS), but not restless limb syndrome (RLS), may be associated with an increased risk of stroke. Preliminary data suggest a high frequency of post-stroke insomnia and RLS and their association with a less favourable stroke outcome, whilst treatment data are scarce. DISCUSSION/CONCLUSION Overall, the evidence base is best for OSA relationship with stroke and supports active diagnosis and therapy. Research gaps remain especially regarding insomnia and RLS/PLMS relationships with stroke.
Published: 2020
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25. A network-based analysis of the association between comorbidities in patients with obstructive sleep apnea using the ESADA network database

Author: Nikolaidis, C., Bailly, S., Mihaicuta, S., Grote, L., McNicholas, W. T., Verbraecken, J., Steiropoulos, P., and Ege Üniversitesi
Abstract: [No abstract available], European Sleep Res Soc
Published: 2020

26. Clinical judgement in mild OSA patients from the European Sleep Apnoea Database (ESADA) study

Author: Bouloukaki, I., Bonsignore, M. R., Grote, L., McNicholas, W. T., Hedner, J., Verbraecken, J., Mihaicuta, S., and Ege Üniversitesi
Subjects: [No Keyword]
Abstract: [No Abstract Available], European Sleep Res Soc
Published: 2020

27. Sex-related differences in young obstructive sleep apnea (OSA) patients: cross-sectional data from the European Sleep Apnea Database (ESADA)

Author: Conti, G., Marrone, O., Steiropoulos, P., Basoglu, O., Ludka, O., Randerath, W., McNicholas, W., Hedner, J., Grote, L., Bonsignore, M., Conti, G., Marrone, O., Steiropoulos, P., Basoglu, O., Ludka, O., Randerath, W., McNicholas, W., Hedner, J., Grote, L., and Bonsignore, M.
Published: 2020

28. EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke

Author: Bassetti, C. L. A., Randerath, W., Vignatelli, L., Ferini-Strambi, L., Brill, A. -K., Bonsignore, M. R., Grote, L., Jennum, P., Leys, D., Minnerup, J., Nobili, L., Tonia, T., Morgan, R., Kerry, J., Riha, R., McNicholas, W. T., Papavasileiou, V., Bassetti, C. L. A., Randerath, W., Vignatelli, L., Ferini-Strambi, L., Brill, A. -K., Bonsignore, M. R., Grote, L., Jennum, P., Leys, D., Minnerup, J., Nobili, L., Tonia, T., Morgan, R., Kerry, J., Riha, R., McNicholas, W. T., and Papavasileiou, V.
Abstract: Background Sleep disorders are highly prevalent in the general population and may be linked in a bidirectional fashion to stroke, which is one of the leading causes of morbidity and mortality. Aim Four major scientific societies established a task force of experts in neurology, stroke, respiratory medicine, sleep medicine and methodology to critically evaluate the evidence regarding potential links and the impact of therapy. Materials and methods Thirteen research questions were evaluated in a systematic literature search using a stepwise hierarchical approach: first, systematic reviews and meta-analyses; second, primary studies post-dating the systematic reviews/meta-analyses. A total of 445 studies were evaluated and 88 were included. Statements were generated regarding current evidence and clinical practice. Results Severe obstructive sleep apnoea (OSA) doubles the risk for incident stroke, especially in young to middle-aged patients. Continuous positive airway pressure (CPAP) may reduce stroke risk, especially in treatment-compliant patients. The prevalence of OSA is high in stroke patients and can be assessed by polygraphy. Severe OSA is a risk factor for recurrence of stroke and may be associated with stroke mortality, whilst CPAP may improve stroke outcome. It is not clear if insomnia increases stroke risk, whilst the pharmacotherapy of insomnia may increase it. Periodic limb movements in sleep (PLMS), but not restless limb syndrome (RLS), may be associated with an increased risk of stroke. Preliminary data suggest a high frequency of post-stroke insomnia and RLS and their association with a less favourable stroke outcome, whilst treatment data are scarce. Discussion/Conclusion Overall, the evidence base is best for OSA relationship with stroke and supports active diagnosis and therapy. Research gaps remain especially regarding insomnia and RLS/PLMS relationships with stroke.
Published: 2020

29. Irish thoracic society: Proceedings of Meeting held November, 1691 in Belfast

Author: Smyth, E. T., Wright, S. C., Sinnamon, D. G., Evans, A. E., MacMahon, J., Loughrey, C., Riley, M., Varghese, G., Buick, J. B., Lowry, R. C., Costello, R., McNicholas, W. T., Quigley, C., Long, M., Conlon, P., Walker, F., Fitzgerald, P., O’Neill, S. J., O’Connor, C. M., Rook, G., FitzGerald, M. X., Subbareddy, K., Luke, D., McGovern, E., Karim, A. F., Luke, D. A., Hogan, F. P., O’Sullivan, M. P., O’Sullivan, M., Grant, W., Walsh, M., Reynolds, S. P., Phillips, A., Richards, R., Jones, K. P., Cunnane, G., Kelly, P., Corcoran, P., Clancy, L., Lyons, D. J., Keating, J., Mulcahy, F., Hartley, P., Goodman, P. G., Houlihan, K. P., Singh, H. P., Aherne, T., Attwood, S. E. A., Wood, A. E., Sweeney, J. P., Hegarty, V., Scott, T., Keane, C., Walsh, J. B., Coakley, D., Donnelly, S., Robinson, C., Zamani, A., McGregor, I., Gordon, M., Steedman, D., Pollock, A., Haslett, C., Cordon, S. M., Elborn, J. S., Rayner, R. J., Hiller, E. J., Shale, D. J., Sinclair, H., Allwright, S., Prichard, J., Macleod, D., Vanderputten, W., O’Briann, D. S., Prichard, J. S., Khan, A., Power, C. K., Morris, A. M., Sreenan, S. K., Burke, C. M., Power, C., Byrne, P., Jarrett, S. J., Hogan, T., Hurson, B., Poulter, L., Clarkson, K., O’Connell, F., Norris, A., Coffey, F., Sreenan, S., Burke, C., MacManus, K., Ritchie, A., Gibbons, J., Stevenson, M., McAuley, W. J., McGuigan, J., Gibbons, J. R., Whiteside, M., Tolan, M., Danton, M., Tolan, M., McGuigan, J. A., Gibbons, J. R. P., Clements, W. B., Kinley, J. K., Johnston, C. F., Gibbons, T. R. P., Buchanan, K. D., Ogunnaike, H. O., Al-Jilaihawi, A. N., Prakash, D., Ghareeb, E. M., Ritchie, A. J., Cosgrove, A. P., O’Donnell, A. F., Neligan, M. C., O’Connor, B. J., Barnes, P. J., O’Connor, B., Donaghy, D., Mulloy, E., McNicholas, W., Northridge, D., Henderson, E., Stanford, C. F., Nichols, P., Dargie, H., Stewart, E. J., Cinnamond, M. J., Nicholls, D. P., Moore, H., Finnegan, P., Gibson, G., Abernethy, E., Plant, L., Bredin, C. P., Murray, J. G., Breathnach, E., Eustace, S., Phelan, N., and Ennis, J. T.
Published: 1992
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30. Modulating effect of respiration on atrioventricular conduction time assessed using PR interval variation

Author: Shouldice, R., Heneghan, C., Nolan, P., Nolan, P. G., and McNicholas, W.
Published: 2002
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31. Chronic kidney disease in European patients with obstructive sleep apnea: the ESADA cohort study

Author: Marrone, O, Battaglia, S, Steiropoulos, P, Basoglu, O, Kvamme, J, Ryan, S, Pepin, J, Verbraecken, J, Grote, L, Hedner, J, Bonsignore, M, Anttalainen, U, Saaresranta, T, Barbé, F, Tasbakan, S, Bielicki, P, Kumor, M, Dumitrascu, R, Schulz, R, Escourrou, P, Roisman, G, Fietze, I, Penzel, T, Kent, B, Mcnicholas, W, Lévy, P, Pépin, J, Tamisier, R, Lavie, L, Lavie, P, Masa, J, Montserrat, J, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Rodenstein, D, Tkacova, R, Varoneckas, G, Vrints, H, Vitols, A., LOMBARDI, CAROLINA, PARATI, GIANFRANCO, ESADA Study Grp, Marrone, O., Battaglia, S., Steiropoulos, P., Basoglu, O., Kvamme, J., Ryan, S., Pepin, J., Verbraecken, J., Grote, L., Hedner, J., Bonsignore, M., Marrone, O, Battaglia, S, Steiropoulos, P, Basoglu, O, Kvamme, J, Ryan, S, Pepin, J, Verbraecken, J, Grote, L, Hedner, J, Bonsignore, M, Anttalainen, U, Saaresranta, T, Barbé, F, Tasbakan, S, Bielicki, P, Kumor, M, Dumitrascu, R, Schulz, R, Escourrou, P, Roisman, G, Fietze, I, Penzel, T, Kent, B, Mcnicholas, W, Lévy, P, Pépin, J, Tamisier, R, Lavie, L, Lavie, P, Lombardi, C, Parati, G, Masa, J, Montserrat, J, Pataka, A, Plywaczewski, R, Sliwinski, P, Pretl, M, Riha, R, Rodenstein, D, Tkacova, R, Varoneckas, G, Vrints, H, and Vitols, A
Subjects: Male, Comorbidity, Body Mass Index, Cohort Studies, Behavioral Neuroscience, 0302 clinical medicine, Risk Factors, Prevalence, obstructive sleep apnea, Aged, 80 and over, Sex Characteristics, Sleep Apnea, Obstructive, Medicine (all), Sleep apnea, General Medicine, Middle Aged, Europe, Hypertension, Cardiology, nephropathy, epidemiology, Female, Glomerular Filtration Rate, Cohort study, Adult, medicine.medical_specialty, Adolescent, Polysomnography, Cognitive Neuroscience, Renal function, Settore MED/10 - Malattie Dell'Apparato Respiratorio, ta3111, Nephropathy, Young Adult, 03 medical and health sciences, Internal medicine, medicine, Humans, Obesity, Renal Insufficiency, Chronic, Aged, Heart Failure, hypoxia, business.industry, medicine.disease, Oxygen, Obstructive sleep apnea, Cross-Sectional Studies, 030228 respiratory system, Heart failure, Physical therapy, Human medicine, business, Body mass index, 030217 neurology & neurosurgery, Kidney disease
Abstract: The cross-sectional relationship of obstructive sleep apnea with moderate to severe chronic kidney disease, defined as an estimated glomerular filtration rate = 30) was found in 34% of subjects. The lowest nocturnal oxygen saturation was 81 +/- 10.2%. Chronic kidney disease prevalence in the whole sample was 8.7% or 6.1%, according to the Modification of Diet in Renal Disease or the Chronic Kidney Disease-Epidemiology Collaboration equations, respectively. Subjects with lower estimated glomerular filtration rate were older, more obese, more often female, had worse obstructive sleep apnea and more co-morbidities (P < 0.001, each). With both equations, independent predictors of estimated glomerular filtration rate < 60 were: chronic heart failure; female gender; systemic hypertension; older age; higher body mass index; and worse lowest nocturnal oxygen saturation. It was concluded that in obstructive sleep apnea, chronic kidney disease is largely predicted by co-morbidities and anthropometric characteristics. In addition, severe nocturnal hypoxaemia, even for only a small part of the night, may play an important role as a risk factor for kidney dysfunction.
Published: 2016

32. Sleep-disordered breathing in the elderly

Author: Bonsignore, M.R., primary and McNicholas, W., additional
Published: 2009
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33. Royal Academy of Medicine in Ireland Section of Biomedical Sciences: Proceedings of Summer Meeting held June 22nd–23rd, 1999

Author: Glasgow, P. D., Hill, I. D., Baxter, G. D., Allen, J. M., Cramp, A. F. L., Noble, J. G., Lowe, A. S., Walsh, D. M., Ryan, S., O’Regan, R. G., McNicholas, W. T., Nolan, P., Corkery, P. P., Leek, B. F., Carroll, O., O’Cuinn, G., Keane, F. M., Clarke, C. R., Robson, T., McKeown, S. R., Moore, S. D., Hirst, D., Sergeant, G. P., Hollywood, M. A., McHale, N. G., Thornbury, K. D., McCloskey, K. D., Magee, P. J., Barnett, C. R., Downes, C. S., Humphrey, R., McGuigan, A., Hutchinson, C., Hannigan, B. M., Saleshando, G., O’Connor, J. J., Curran, B. P., O’Neill, L. A. J., Kerrigan, S. W., Quinn, M., Fitzerald, D. J., Cox, D., Dunne, E. M., Herron, C. E., O’Loinsigh, E., Boland, G., O’Boyle, K. M., Cullen, V. C., Mackarel, A. J., O’Connor, C. M., Keenan, A. K., Cannon, D. M., McBean, G., Baird, A. W., Frizelle, H. P., Moriarty, D. C., McGuire, M., Bradford, A., Ryan, J. P., Quinn, T., Walker, M. D., Hirst, D. G., Hurley, D. A., McDonough, S. M., Moore, A., Lagan, K. M., Dusoir, A. E., Wilson, S., Sweeney, C., Curtis, T. M., Scholfield, C. N., O’Connor, S., Kilbride, E., McLoughlin, P., Gallagher, C. G., Harty, H. R., and Gormley, B. -A.
Published: 1999
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34. EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke

Author: Bassetti, C. L. A., primary, Randerath, W., additional, Vignatelli, L., additional, Ferini‐Strambi, L., additional, Brill, A.‐K., additional, Bonsignore, M. R., additional, Grote, L., additional, Jennum, P., additional, Leys, D., additional, Minnerup, J., additional, Nobili, L., additional, Tonia, T., additional, Morgan, R., additional, Kerry, J., additional, Riha, R., additional, McNicholas, W. T., additional, and Papavasileiou, V., additional
Published: 2020
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35. Challenges and perspectives in obstructive sleep apnoea

Author: Randerath W., Bassetti C. L., Bonsignore M. R., Farre R., Ferini-Strambi L., Grote L., Hedner J., Kohler M., Martinez-Garcia M. -A., Mihaicuta S., Montserrat J., Pepin J. -L., Pevernagie D., Pizza F., Polo O., Riha R., Ryan S., Verbraecken J., McNicholas W. T., Randerath, W., Bassetti, C. L., Bonsignore, M. R., Farre, R., Ferini-Strambi, L., Grote, L., Hedner, J., Kohler, M., Martinez-Garcia, M. -A., Mihaicuta, S., Montserrat, J., Pepin, J. -L., Pevernagie, D., Pizza, F., Polo, O., Riha, R., Ryan, S., Verbraecken, J., and Mcnicholas, W. T.
Subjects: Europe, Sleep Apnea, Obstructive, Polysomnography, Humans, Comorbidity, Societies, Medical
Abstract: Obstructive sleep apnoea (OSA) is a major challenge for physicians and healthcare systems throughout the world. The high prevalence and the impact on daily life of OSA oblige clinicians to offer effective and acceptable treatment options. However, recent evidence has raised questions about the benefits of positive airway pressure therapy in ameliorating comorbidities. An international expert group considered the current state of knowledge based on the most relevant publications in the previous 5 years, discussed the current challenges in the field, and proposed topics for future research on epidemiology, phenotyping, underlying mechanisms, prognostic implications and optimal treatment of patients with OSA. The group concluded that a revision to the diagnostic criteria for OSA is required to include factors that reflect different clinical and pathophysiological phenotypes and relevant comorbidities (e.g. nondipping nocturnal blood pressure). Furthermore, current severity thresholds require revision to reflect factors such as the disparity in the apnoea–hypopnoea index (AHI) between polysomnography and sleep studies that do not include sleep stage measurements, in addition to the poor correlation between AHI and daytime symptoms such as sleepiness. Management decisions should be linked to the underlying phenotype and consider outcomes beyond AHI.
Published: 2018

36. Change in weight and central obesity by positive airway pressure treatment in obstructive sleep apnea patients: longitudinal data from the ESADA cohort

Author: Basoglu, Ozen K., Zou, Ding, Tasbakan, Mehmet S., Hedner, Jan, Ryan, Silke, Verbraecken, Johan, Escourrou, Pierre, Antalainen, Ulla, Kvamme, John A., Bonsignore, Maria R., Schiza, Sofia, Grote, Ludger, Anttalainen, U., Barbé, F., Bielicki, P., Dogas, Z., Fietze, I., Hein, H., Joppa, P., Levy, P., Lombardi, C., Marrone, O., Masa, J. F., McNicholas, W. T., Montserrat, J. M., Parati, G., Pataka, A., Penzel, T., Pépin, J. L., Petiet, E., Plywaczewski, R., Pretl, M., Riha, R. L., Roisman, G., Ryan, S., Saaresranta, T., Schulz, R., Sliwinski, P., Pepin, J. L., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Vitols, A., Basoglu OK, Zou D, Tasbakan MS, Hedner J, Ryan S, Verbraecken J, Escourrou P, Antalainen U, Kvamme JA, Bonsignore MR, Schiza S, Grote L, ESADA Study Group., ESADA Study Grp, Basoglu, O, Zou, D, Tasbakan, M, Hedner, J, Ryan, S, Verbraecken, J, Escourrou, P, Antalainen, U, Kvamme, J, Bonsignore, M, Schiza, S, Grote, L, Anttalainen, U, Barbé, F, Bielicki, P, Dogas, Z, Fietze, I, Hein, H, Joppa, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Mcnicholas, W, Montserrat, J, Parati, G, Pataka, A, Penzel, T, Pépin, J, Petiet, E, Plywaczewski, R, Pretl, M, Riha, R, Roisman, G, Saaresranta, T, Schulz, R, Sliwinski, P, Pepin, J, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, and Vitols, A
Subjects: Data Analysis, Male, Time Factors, Excessive daytime sleepiness, Weight Gain, excessive daytime sleepine, Body Mass Index, Cohort Studies, Behavioral Neuroscience, 0302 clinical medicine, Positive airway pressure, Medicine, Longitudinal Studies, Prospective Studies, obstructive sleep apnea, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, Epworth Sleepiness Scale, Sleep apnea, General Medicine, Middle Aged, weight, central obesity, positive airway pressure, ESADA cohort, Europe, Obesity, Abdominal, Cardiology, Female, Waist Circumference, medicine.symptom, Adult, medicine.medical_specialty, Cognitive Neuroscience, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, Internal medicine, Humans, Aged, business.industry, Body Weight, body weight, central obesity, excessive daytime sleepiness, obstructive sleep apnea, positive airway pressure, ta3121, medicine.disease, Obesity, respiratory tract diseases, Obstructive sleep apnea, 030228 respiratory system, Human medicine, business, Body mass index, Weight gain, 030217 neurology & neurosurgery
Abstract: The effect of positive airway pressure treatment on weight and markers of central obesity in patients with obstructive sleep apnea remains unclear. We studied the change in body weight and anthropometric measures following positive airway pressure treatment in a large clinical cohort. Patients with obstructive sleep apnea with positive airway pressure treatment from the European Sleep Apnea Database registry (n = 1, 415, 77% male, age 54 ± 11 [mean ± SD] years, body mass index 31.7 ± 6.4 kg/m2, apnea–hypopnea index 37 ± 24 n per hr, Epworth Sleepiness Scale 10.2 ± 5.0) were selected. Changes in body mass index and neck/waist/hip circumferences at baseline and at follow-up visit were analysed. Overall, body mass index (0.0 [95% confidence interval, −0.1 to 0.2] kg/m2) and neck circumference (0.0 (95% confidence interval, −0.1 to 0.1] cm) were unchanged after positive airway pressure treatment compared with baseline (follow-up duration 1.1 ± 1.0 years and compliance 5.2 ± 2.1 hr per day). However, in non- obese (body mass index
Published: 2018

37. Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?

Author: Ryan, S, Taylor, C T, and McNicholas, W T
Published: 2009
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38. Examination of inter-night variability of apnoea-hypopnoea index estimation from a combined Holter-oximeter: P199

Author: BOYLE, P., GARVEY, J., CHUA, C., DE CHAZAL, P., SHOULDICE, R., HENEGHAN, C., and MCNICHOLAS, W. T.
Published: 2008

39. Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study

Author: Pataka, Athanasia Bonsignore, Maria R. Ryan, Silke Riha, Renata L. Pepin, Jean-Louis Schiza, Sofia Basoglu, Ozen K. and Sliwinski, Pawel Ludka, Ondrej Steiropoulos, Paschalis and Anttalainen, Ulla McNicholas, Walter T. Hedner, Jan Grote, Ludger Steiropoulos, P. Verbraecken, J. Petiet, E. and Trakada, G. Montserrat, J. M. Fietze, I. Penzel, T. and Ludka, O. Rodenstein, D. Masa, J. F. Bouloukaki, I. and Schiza, S. Kent, B. McNicholas, W. T. Ryan, S. Riha, R. L. Kvamme, J. A. Schulz, R. Grote, L. Hedner, J. and Pepin, J-L. Levy, P. Lavie, L. Lavie, P. Hein, H. and Basoglu, O. K. Tasbakan, M. S. Varoneckas, G. Joppa, P. and Safarik, P. J. Tkacova, R. Staats, R. Barbe, F. and Lombardi, C. Parati, G. Drummond, M. van Zeller, M. and Bonsignore, M. R. Marrone, O. Escourrou, P. Roisman, G. and Pretl, M. Vitols, A. Dogas, Z. Galic, T. Pataka, A. and Anttalainen, U. Saaresranta, T. Sliwinski, P. Plywaczewski, R. Bielicki, P. ESADA Study Grp
Published: 2019

40. Irish Thoracic Society: Proceedings of Annual Scientific Meeting held in Dublin on 4th & 5th November, 1994

Author: Feeney, T., O’Muire, O., Gilmartin, J. J., Manning, P., Sinclair, H., Clancy, L., O’Connell, F., Springall, D. R., Polak, J. M., Thomas, V. E., Fuller, R. W., Pride, N. B., Lyons, R. A., Leonard, C., Faul, J., Tormey, V. J., Poulter, L. W., Burke, C. M., Pathmakanthan, S., Barry, M. C., Wang, J. H., Kelly, C. J., Burke, P. E., Sheehan, S. J., Redmond, H. P., Bouchier-Hayes, D., Abdih, H., Watson, R. W. G., Burke, P., Egan, J. J., Barber, L., Lomax, J., Fox, A., Craske, J., Yonan, N., Rahman, A. N., Deiraniya, A. K., Carroll, K. B., Turner, A., Woodcock, A. A., McNeill, K., Bookless, B., Gould, K., Corris, P., Higgenbottam, T., Webb, A., Woodcock, A., McManus, K., Miller, D., Allen, M., Ilstrup, D., Deschamps, C., Trastek, V., Pairolero, P., Cotter, T. P., Vaughan, C., Kealy, W. P., Duggan, P. F., Curtain, A., Bredin, C. P., Waite, A., Maguire, C. P., Ryan, J., O’Neill, D., Coakley, D., Walsh, J. B., Kilgallen, I., O’Neill, S., Ryan, M., O’Connor, C. M., McDonnell, T., Lowry, R. C., Buick, J. B., Magee, T. R. A., O’Riordan, D., Hayes, J., O’Connor, C., FitzGerald, M. X., Cosgrave, C., Costello, C., Deegan, P. C., McNicholas, W. T., Nugent, A. M., Lyons, J., Gleadhill, I., MacMahon, J., Stevenson, E. C., Heaney, L. G., Shields, M. D., Cadden, I. S., Taylor, R., Ennis, M., Kharitonov, S. A., O’Connor, J., Owens, W. A., O’Kane, H., Cleland, J., Gladstone, D. J., Sarsam, M., Graham, A. N. J., Anikin, V., McGuigan, J. A., Curry, R. C., Varghese, G., Keelan, P., Rutherford, R., O’Keeffe, D., McCarthy, P., Gilmartin, J. J., Moore, H., Balbernie, E., Gilmartin, J. J., Coakley, R., Keane, M., Costello, R., Byrne, P., McKeogh, D., McLoughlin, P., Finlay, G., Concannon, D., McKeown, D., Kelly, P., Tanner, W. A., Bouchier-Hayes, D. J., Arumugasamy, M., Yacoub, K., O’Leary, G., Stokes, K., Geraghty, J., Osborne, H., O’Dwyer, R., Gilliland, R., Saleem, S. M., Aherne, T., Power, C. K., Burke, C. H., Byrne, A., Murphy, J. F. A., Sharkey, R., Mulloy, E., Sharkey, K., Long, M., Birchall, M. A., Moorat, A., Henderson, J., Jacques, L., Cahill, P., Condron, C., Royston, D., Murphy, J., and Neill, S. O.
Published: 1995
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41. Irish thoracic society: Proceedings of Annual Meeting held in Galway on November 6th & 7th, 1992

Author: Quigley, C., Mofidi, R., Liu, G., O’Connor, C., FitzGerald, M. X., Johnson, H., MacDonnell, T., Lee, B., Kelly, E., Doherty, E., McCarthy, J. F., Hurley, J., Wood, A. E., Lynch, V. P., Ellias, E., Tahir, M., Asad Ali, S., Istarabadi, M., Hussain, R., McGovern, Ms. E., Luke, D. A., Murphy, M., Mealy, K., Little, D., Burke, P., O’Neill, S., Broe, P., Guidon, M., Long, M., Reid, P. T., MacMahon, J., Babu, M. V. S., Watson, J. B. G., O’Halloran, E. T., Kumar, P., Shortt, C., Murphy, S., Hegarty, V., Scott, T., Keane, C. T., Walsh, J. B., Coakley, D., Clancy, L., Corcoran, P., Kelly, P., Healy, T., Moore, H., Cormican, M., Flynn, J., Gilmartin, J. J., O’Connor, H., Power, W., McNicholas, N., Lindsay, P. J., Noone, D., Glennon, M., Smith, T., Gannon, F., O’Dwyer, R., Stack, N., Kyne, K., McHale, E., Sidhu, P., O’ Sullivan, R., Callaghan, J., Wilkinson, P., McKenzie, G., O’Connor, C. M., Ryan, M., Shanahan, P., O’Donnel, N., Conlon, P., O’Neill, G., Long, H., Carmody, M., Keogh, B., Donohoe, J., Walshe, J., Lyons, D. J., Madrigal, L., Luke, D., McKinley, R. K., Jamison, J. P., Sreenan, S. K., Power, C. K., Pathmakanthan, S., Burke, C. M., Poulter, L. W., O’Donovan, D. A., Bouchier-Hayes, D. M., Kelly, C., Grace, P., Redmond, H. P., Monkhouse, W. S., Bouchier-Hayes, D., Bourke, W. J., McDonnell, T. J., Cotter, T. P., Bredin, C. P., Hayes, J. P., Ward, K., Muldowney, F., Othman, S., Conroy, R., Collum, C., Durity, M., Power, J., Gaffney, K., Southey, A., Keane, J., Byrne, N., Hayes, J., Magee, T. R. A., Buick, J. B., Lowry, R. C., Kelly, C. J., Shou, J., Gallagher, H., Daly, J. M., Bouchier-Hayes, D, Donnelly, S. C., Haslett, C., Grant, I. S., Streiter, R. M., Kunkel, S. L., Walz, A., Robertson, C. R., Carter, D. C., Pollock, A. J., O’Neill, M., Dockrell, D., Rooney, M., Memon, I., Loftus, B. G., Mulcahy, R., Periappuram, Murphy, P., Mulroy, Sr. M., Taylor, M. R. H., Costello, R., McNicholas, W. T., Watson, R. G. W., and O’Neill, S. J.
Published: 1993
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42. Clinical phenotypes and comorbidity in European sleep apnoea patients

Author: Saaresranta T., Hedner J., Bonsignore M. R., Riha R. L., McNicholas W. T., Penzel T., Anttalainen U., Kvamme J. A., Pretl M., Sliwinski P., Verbraecken J., Grote L., Barbe F., Basoglu B., Bielicki P., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Hayes L., Kumor M., Kurki S., Lavie L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., Montserrat J. M., Parati G., Pataka A., Pepin J. L., Plywaczewski R., Rodenstein D., Roisman G., Ryan S., Schulz R., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Vitols A., Vrints H., Zielinski J., Saaresranta, T, Hedner, J, Bonsignore, M, Riha, R, Mcnicholas, W, Penzel, T, Anttalainen, U, Kvamme, J, Pretl, M, Sliwinski, P, Verbraecken, J, Grote, L, Barbe, F, Basoglu, B, Bielicki, P, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kumor, M, Kurki, S, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Montserrat, J, Parati, G, Pataka, A, Pepin, J, Plywaczewski, R, Rodenstein, D, Roisman, G, Ryan, S, Schulz, R, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Vrints, H, Zielinski, J, ESADA Study Group, Ege Üniversitesi, ESADA Study Grp, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Saaresranta, T., Hedner, J., Bonsignore, M., Riha, R., Mcnicholas, W., Penzel, T., Anttalainen, U., Kvamme, J., Pretl, M., Sliwinski, P., Verbraecken, J., Grote, L., Barbé, F., Basoglu, B., Bielicki, P., Dorkova, Z., Escourrou, P., Fietze, I., Esquinas, C., Hayes, L., Kumor, M., Kurki, S., Lavie, L., Lavie, P., Levy, P., Lombardi, C., Marrone, O., Masa, J., Montserrat, J., Parati, G., Pataka, A., Pépin, J., Plywaczewski, R., Rodenstein, D., Roisman, G., Ryan, S., Schulz, R., Tkacova, R., Staats, R., Steiropoulos, P., Varoneckas, G., Vitols, A., Vrints, H., and Zielinski, J.
Subjects: Male, Pulmonology, Physiology, Apnea, medicine.medical_treatment, lcsh:Medicine, Comorbidity, Polysomnography, Cardiovascular Medicine, Medicine (all), Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), THERAPY, Body Mass Index, 0302 clinical medicine, Risk Factors, Positive airway pressure, Medicine and Health Sciences, Insomnia, Medicine, Prospective Studies, Continuous positive airway pressure, lcsh:Science, Prospective cohort study, Clinical Neurophysiology, Aged, 80 and over, Hypersomnia, Multidisciplinary, medicine.diagnostic_test, Sleep apnea, Middle Aged, DEPRESSION, PREVALENCE, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, Phenotype, Neurology, Physiological Parameters, Cardiovascular Diseases, CARDIOVASCULAR-DISEASE, Female, InformationSystems_MISCELLANEOUS, medicine.symptom, Engineering sciences. Technology, Hypopnea, INSOMNIA SYMPTOMS, Research Article, Adult, medicine.medical_specialty, Sleep Apnea, Adolescent, POSITIVE AIRWAY PRESSURE, Settore MED/10 - Malattie Dell'Apparato Respiratorio, White People, Young Adult, 03 medical and health sciences, Sleep Apnea Syndromes, DAYTIME, stomatognathic system, Comorbiditat, Diagnostic Medicine, Internal medicine, mental disorders, Humans, COMMON, Aged, HYPOPNEA, HYPERTENSION, business.industry, lcsh:R, Body Weight, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Biology and Life Sciences, ta3121, medicine.disease, Dyssomnias, respiratory tract diseases, nervous system diseases, ComputingMethodologies_PATTERNRECOGNITION, 030228 respiratory system, Physical therapy, lcsh:Q, Sleep Disorders, Physiological Processes, Sleep, business, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract: PubMed ID: 27701416, Background Clinical presentation phenotypes of obstructive sleep apnoea (OSA) and their association with comorbidity as well as impact on adherence to continuous positive airway pressure (CPAP) treatment have not been established. Methods A prospective follow-up cohort of adult patients with OSA (apnoea-hypopnoea index (AHI) of ?5/h) from 17 European countries and Israel (n = 6,555) was divided into four clinical presentation phenotypes based on daytime symptoms labelled as excessive daytime sleepiness ("EDS") and nocturnal sleep problems other than OSA (labelled as "insomnia"): 1) EDS (daytime+/nighttime-), 2) EDS/insomnia (daytime+/nighttime+), 3) non-EDS/noninsomnia (daytime-/nighttime-), 4) and insomnia (daytime-/nighttime+) phenotype. Results The EDS phenotype comprised 20.7%, the non-EDS/non-insomnia type 25.8%, the EDS/ insomnia type 23.7%, and the insomnia phenotype 29.8% of the entire cohort. Thus, clinical presentation phenotypes with insomnia symptoms were dominant with 53.5%, but only 5.6% had physician diagnosed insomnia. Cardiovascular comorbidity was less prevalent in the EDS and most common in the insomnia phenotype (48.9% vs. 56.8%, p
Published: 2016

43. Intranasal corticosteroid therapy for obstructive sleep apnoea in patients with co-existing rhinitis

Author: Kiely, J L, Nolan, P, and McNicholas, W T
Published: 2004

44. Sarcoidosis presenting as upper extremity venous thrombosis

Author: McLaughlin, A M and McNicholas, W T
Published: 2003

45. Selected abstracts

Author: Corkery, P. P., Leek, B. F., Caulfield, B., Garrett, M., Gormley, J. P., OʼDonnell, P. M., Kennedy, N., Sayers, K., Stokes, E., Bresnihan, B., Fitzgerald, O., McGarvey, M. A., Tonra, M., Hooper, A. C. B., Barry, J., Maurer, B., Hussey, J., Gormley, J., Noble, J. G., Alves-Guerreiro, J., Lowe, A. S., Walsh, D. M., NicNiocaill, B., Harte, M., OʼConnor, W. T., OʼHara, A. M., Orren, A., Moran, A. P., Hardiman, D. A., Lee, T. C., Croke, D. T., Tolan, R., McBennett, S., Warmington, S., McGuire, M., Bradford, A., OʼHare, T., MacDermott, M., Lynch, F., OʼRegan, R. G., McLoughlin, P., Quinn, T., Ryan, J. P., Pickering, M., Campion, D. P., Jones, J. F. X., Ryan, S., McNicholas, W. T., Nolan, P., Doyle, F. J., Rackard, S. M., Beddy, P., Campbell, V. A., Bakhle, Y. S., Bell, C., Usher, C., Chan, L., Keenan, A. K., McQuaid, K. E., Cullen, V. C., Smith, E. M., Kelly, A., Lynch, M. A., Freir, D. B., Holscher, C., Herron, C. E., Pearson, H. A., Curran, B. P., OʼConnor, J. J., Quinn, A., McHale, J., Moriarty, D., OʼConnor, J., Glennon, J. C., Van Vliet, B. J., Long, S. K., Kruse, C., Gallagher, H. C., Bacon, C. L., Boland, B., Griffin, A. M., Preisler, J., OʼBrien, L., Regan, C. M., Hurley, S., Kearney, P. J., Slevin, J., Barry-Kinsella, C., Ryan, C. A., Kllleen, O., Glllan, J., Clarke, T., Matthews, T., Corcoran, D., Dunn, E., Geary, M., OʼHerlihy, C., Keane, D., OʼLeary, M. J., Morrison, J. J., Ryan, E., Gorman, W. A., Bourke, A., Larkin, J., Mayes, C., Jenkins, J., Ryan, M., Lalchandani, S., Sheil, O., Lynch, N., Costigan, C., Murphy, J. F., Bhatia, R., Foran, A., Donohue, V., McParland, P., LaSjaunais, P., Rodesch, G., McGinn, M., McAloon, J., OʼLeary, M., Astbury, K., Harmon, D., Sharkey, A., Gaffney, G., OʼRegan, G., McMahon, C., Murray, D., McDermott, C., Woolhead, E., Gillan, J., Cartmill, J. L., Harper, M. A., Al-Shabibi, N., Hanahoe, M., Wingfield, M., Larkin, J. A. M., Bell, A. H., McClure, B. G., Sweeney, L., Martin, D. H., OʼDonoghue, P., Davoren, A., Lucas, G. F., McKiernan, J., Gallagher, D. M. T., Dunne, K. P., Fulena, O., Sheridan, M., Griffin, E., White, M., Deasy, P., OʼRiordan, M., OʼGorman, C., Mongan, C., McCafferkey, M., Henry, G., McKenna, P., OʼMalley, A., Devaney, D., Kelleghan, P., Mooney, E. E., Gillan, J. E., Fitzpatrick, M., McQuillan, K., Heffron, C., Hodnett, P., Curtain, A., OʼConnor, T. C. F., Connell, T. G., Waldron, D., Gorman, W., Bolger, T., OʼKeefe, M., Murphy, J., Dolan, L. M., Traub, A. I., Slattery, M. M., Curley, A. E., Halliday, H. L., Tubman, T. R. J., Kileen, O., Riadha, H., Russell, J., Philips, R., Regan, C., Ali, I., Coughlan, A. C. J., Turner, M. J., Smith, A., OʼFlanagan, D., Igoe, D., Ryan, F., Forde, D., McArdle, E., Ko, D., Bedford, D., Hegarty, M., Dunlevy, B., Corcoran, R., Holohan, T., Feeney, A., McGee, H., Shannon, W., Condon, M., Hyland, C., Sayers, G., Feely, E., Crowley, D., OʼReilly, D., OʼConnell, T., Cronin, M., Johnson, H., Fitzgeraldi, M., Cafferkey, M., Breslin, A., Bonner, C. J., Foley, B., Fitzgerald, M., Wall, P. G., McNamara, E., Costigan, P., Prendergast, T., Foye, K., Cosgrove, C., Keane, A., Murphy, E., OʼDonnell, J., Quinlan, A., Thornton, L., Roch, E. A., Lyons, R. A., Maddocks, A., Barnes, P., Price, L., McCabe, M., Nash, P., Midha, A., Doyle, Y., Kilgallen, A., Wright, P., Ryan, T., De La Harpe, D., Harkins, V., Brennan, C., OʼConnell, V., Evans, D. S., Mhuircheartaigh, Ni J., OʼDonnell, J. M., Rhatigan, A., Shelley, E., Collins, C., Byrne, M., Murphy, A. W., Plunkett, P. K., Murray, A., Bury, G., Lynam, F., McMahon, G., Greally, T., Kane, D., Veale, D., Reece, R., Busteed, S., Bennett, M. W., Stone, M., Molloy, C., OʼConnell, J., Molloy, M. G., Shanahan, F., Guerin, J., Casey, E., Feighery, C., Lin, F., Jackson, J., Pendleton, A., Wright, G. D., Hughes, A. E., OʼGradaigh, D., Debham, I., Compston, J., McEvoy, A., Murphy, E. P., Salonen, D., Payne, P., Lax, M., Lapp, V., Inman, R., OʼRourke, K., Brennan, D., Harty, J., McCarthy, C., OʼByrne, J., Eustace, S., Chirayath, H., Liggett, N. W., Morgan, M. P., Fitzgerald, D. J., McCarthy, C. J., McCarthy, G. M., Lee, R. Z., Wai, K., Nevin, D., Leary, A. O., Lee, R., Casey, E. B., OʼLeary, A., Breen, D., Tuite, D., McInerney, D., Sim, R., Frederic, A. L., Smith, O., White, B., Murphy, M., Silke, C., OʼKeeffe, E., Fanning, N., Spence, L., Parfrey, N. A., McConnell, J. R., Crockard, A. D., Cairns, A. P., Bell, A. L., Kavanagh, O., Moyes, D. A., Finch, M., Rooney, M., Bell, A., Founas, I., El-Magbri, A., Mooney, S., Kennedy, M., Coughlan, R. J., Ramakrishnan, S. A., Gsel, A., Finnerty, O., Burns, M., Yateman, M., Camaco-Hubner, C., Matthews, C. F., Taggart, A., Fuller, K., Murphy, M. S., Phelan, M., Murphy, T. B., Wynne, F., Quane, K., Daly, M., OʼLeary, J., da Silva, I., Bermingham, N., Gogarty, M., Gallagher, L. P., OʼHara, R., Godson, C., Brady, H., Osman, H., El-Rafie, A., Foley-Nolan, D., Kirwan, P., Corcoran, O., Duffy, T., Drummond, F., Madigan, A., Williams, D., Gallagher, P., Hatton, C., Cunningham, S., FitzGerald, O., Minnock, P., Wylie, E., Egan, D., Mc Cormack, J., Shea, M. O., Evans, D., OʼLorcain, P., Comber, H., Evans, A., Jones, J., Garavan, C., Kelleher, K., Boland, M. C., Healy, R., OʼSullivan, M. B., Burke, M., Mc Donald, P., Smithson, R., Glass, J., Mason, C. A., Mullins, N., Nolan, D., McCormick, P., Coughlan, S., Dooley, S., Kelleher, C. C., Hope, A., Murphy, F., Barry, M., Sixsmith, J., MacFarlane, A., MacLeod, C., McElroy, G., OʼLoan, D., Kennedy, F., Kerr, R. M., Lim, J., Allwright, S. P. A., Bradley, F. L., Barry, J. M. G., Long, J., Parry, J. V., Creagh, D., Perry, I. J., Collins, A., Neilson, S., Colwell, N., OʼHalloran, D., OʼNeill, S., McErlain, S., Okasha, M., Gaffney, B., McCarron, P., Hinchion, R., Drew, C., Gavin, A., Fitzpatrick, D., Campbell, R., Wannamethee, S. G., Shaper, A., Friel, S., Kelleher, C., Kee, F., Atterson, C. C., Wilson, E. A., McConnell, J. M., Wheeler, S. M., Watson, J. D., Rahman, Norashikin N., Sheehan, J., Wall, C., Kelleher, B., OʼBroin, S. D., Mullan, R. N., McKeveney, P. J., Hodges, V. M., Winter, P. C., Maxwell, P., Simpson, D. A., Lappin, T. R. J., Maxwell, A. P., Eustace, J. A., Coresh, J., Kutchey, C., Te, P. L., Gimenez, L. F., Scheel, P. J., Walser, M., McMahon, R. A., Clarkson, M., Martin, F., Brady, H. R., Blake, C., OʼMeara, Y. M., Gupta, S., MacKenzie, H., Doyle, S., Fotheringham, T., Haslam, P., Logan, M. P., Conlon, P., Lee, M., Maderna, P., Cottell, D. C., Mitchell, S., Gulmann, C., Østerby, R., Bangstad, H. J., Rljdberg, S., Dempsey, M., Nathwani, S., Ryan, M. P., McMahon, B., Stenson, C., Murtagh, H., Brown, J. H., Doran, P., McGinty, A., Little, M. A., OʼBrien, E., Owens, P., Holian, J., Mee, F., Walshe, J. J., Omer, S. A., Power, D., Diamond, P., Watson, R. W., Shahsafei, A., Jiang, T., Brenner, B. M., Mackenzie, H. S., Neary, J., Dorman, A., Keoghan, M., Campbell, E., Walshe, J., Little, M., Nee, L., OʼCeallaigh, C., McGlynn, H., Bergin, E., Keane, T., Gormley, G., Watson, A., Atta, M. G., Perl, T. M., Song, X., Healy, E., Leonard, M., Lynch, J., Watson, A. J., Lappin, D., Lappin, D. W. P., Hannan, K., Burne, M., Daniels, F., Rabb, H., McBride, B., Kieran, N., Shortt, C., Codd, M., Murray, F., McCormack, A., Brown, C., Wong, C., Dorman, A. M., Keogan, M., Donohue, J., Farrell, J., Donohoe, J., OʼBroin, S., Balfe, A., Mellotte, G. J., Abraham, K. A., McGorrian, C., Wood, A. E., Neligan, M., Kelly, B. D., Finnegan, P., Cormican, M., Callaghan, J., Crean, J. K. G., Moffitt, T. A., Devlin, H. L., Garrett, P. J., Soosay, A., OʼNeill, D., Counihan, A., Hickey, D., Keogan, M. T., Harvey, K., OʼRiordan, E., Waldek, S., Kalra, P. A., OʼDonoghue, D. J., Foley, R. N., Kelliher, D., Mellotte, G., Giblin, L., Keogh, J. A. B., OʼConnell, M., OʼMeara, A., Breatnach, F., Gillick, J., Tazawa, H., Puri, P., Molloy, E., OʼNeill, A. J., Sheridan-Pereira, M., Fitzpatrick, J. M., Webb, D. W., Watson, R. W. G., Linnane, B., OʼDonnell, C., Clarke, T. A., Martin, C., McKay, M., McBrien, J., Glynn, F., OʼDonovan, C., Hall, W. W., Smith, J., Khair, K., Liesner, R., Hann, I. M., Smith, O. P., Gallagher, S., Mahony, M. J., Hilal, A., Cosgrove, J. F., Monaghan, C., Craig, B., Walsh, K., Duff, D., Slizlok, P. O., Halahakoon, C., McMillan, S., Dalzell, E. E., McCaughan, J., Redmond, A. O. B., DeCaluwe, D., Yoneda, A., Akl, U., Dempsey, E., Farrell, M., Webb, D., Elabbas, A., Fox, G., Gormally, S., Grant, B., Corkey, C. W. B., Nicholson, A., Murphy, A., OʼGrady, P., Barry, O., Stewart, M. C., Alderdice, F., Matthews, T. G., McDonnell, M., McGarvey, C., OʼRegan, M., Chróinín, Ní M., Tormey, P., Ennis, S., Green, A. J., Abbas, S., OʼMarcaigh, A., Conran, M., Crushell, E., Saidi, A., Curran, P., Donoghue, V., King, M. D., Elnazir, B., Leonard, J., Kavanagh, C., Brown, D., Corrigan, N., McCord, B., Quinn, M., OʼConnell, L., Mcdonagh, B., Awan, A., Gill, D., Kakkar, R., Warner, J. A., OʼConnor, C., Herzig, M., Twomey, A., White, M. J., Sweeney, B., Surana, R., Hodgson, A., Rafferty, M., Livingstone, W., Peake, D., Wassemer, E., Whitehouse, W., Abdullah, N., Al-Hassan, A., Oslizlok, P., OʼConnell, N., Balding, J., Livingstone, W. J., Healy, M., Mynett-Johnson, L., McAllister, I., Dick, A. C., Herron, B., Boston, V. E., Callaghan, C. O., Brien, D. O., Walsh, A., Philip, M., McShane, D., Hoey, M. C. V., Sharif, F., McDermott, M., Dillon, M., Drumm, B., Rowland, M., Imrie, C., Kelleher, S., Bourke, B., Iqbal, M., Ziedan, Y., OʼNeill, M., OʼRiordan, S., Basheer, S. M. B., OʼCallaghan, S., Chong, A., Kelly, M., Nicholson, A. J., Cooke, R., Sreenan, C., Fallon, M., Denham, B., Dowding, V., Cussen, G., McManus, V., Hensey, O., Monaghan, H., Basheer, S. N., Quinn, E., Hoey, H. M. C. V., Mohamed, S., Ramesh, R. R., Mayne, P., Tracy, E., Gormally, S. M., Curtis, E., McCallion, N., Watson, R., OʼMahony, O., Keegan, M., Ward, K., Barton, D., Poulton, J., Treacy, E., Honour, J., deCaluwe, D., Chróinín, Ni M., Cosgrove, J., Chaudhry, T. S., Long, N. M., Lynch, B., Lasjaunais, P., McDonald, D. G. M., McMenamin, J. B., Farrell, M. J., Roche, E. F., Menon, A., Buckley, C., Mackey, A., Ohlandieck, K., Das, A., Reilly, D., Killeen, O., Harper, J., Roche, E., Hoey, H., Caird, J., OʼBrien, D., Allcutt, D., Farrington, N., Murphy, J. F. A., Savage, J. M., Sands, A. J., Casey, F. A., Craig, B. G., Dornan, J. C., Johnston, J., Patterson, C., Lynch, C., Mulholland, H. C., Watkins, D. C., Young, I., Cran, G., Boreham, C. A. G., McCallion, W. A., Clements, N. F., Stevenson, M. R., Macpherson, C., Jenkins, L., Thompson, A. J., Shields, M. D., Taylor, R. T., Kerr, R., Hughes, J. L., Stewart, M., Jackson, P., Fitzpatrick, C., Rasheed, M., Colhoun, E., Bailie, A. G., Gray, S., Brown, S., Curley, A., Sweet, D. G., MacMahon, K. J., OʼConnor, C. M., Nichelson, A., Lynch, N. E., Finch, D., Foley, M., Scallan, E., Dillon, B., Lyons, S., OʼLoughlin, R., Ward, M., Nally, R., Harkin, A., Kelly, J. P., Leonard, B. E., Magee, P., Connor, T. J., Shen, Y., McCullough, G. R., McDonough, S. M., Niocaill, Nic B., Cramp, A. F. L., Hynes, M., Corkery, P., Carey, M., McGarrigle, D., Higgins, S., Murray, H., Moran, C. J., Dennedy, M. C., Brosnan, J., Morris, L., Sheppard, B. L., Black, A., Wilkins, B., Folan-Curran, J., Skelton, K., Owens, M., Nemeroff, C., Houlihan, D., OʼKeeffe, C., Nolan, N., McCormick, P. A., Baird, A. W., Raducan, I., Corcoran, P., Brennan, R., Molloy, P., Friel, A., Maher, M., Glennon, M., Smith, T., Nolan, A., Houghton, J. A., Carroll, O., Colleran, S., OʼCuinn, G., Snow, H. M., OʼRegan, D., Markos, H. F., Pollock, K., Cannon, D. M., McBean, G., OʼRiordan, A., Quinlan, L. R., Kane, M. T., Higglns, B. D., Moriarty, D. M., Fitzgerald, D., Katkada, A., Canny, G., MacMathuna, P., OʼDonoghue, D., OʼDonovan, M. M., Schuur, A. G., Murphy, K. J., Foley, A. G., ten Bruggencate, S. J. M., and Ireland, L.
Published: 2000
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46. Clinical phenotypes and comorbidity in European sleep apnoea patients

Author: Saaresranta, T, Hedner, J, Bonsignore, M, Riha, R, Mcnicholas, W, Penzel, T, Anttalainen, U, Kvamme, J, Pretl, M, Sliwinski, P, Verbraecken, J, Grote, L, Barbe, F, Basoglu, B, Bielicki, P, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kumor, M, Kurki, S, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Montserrat, J, Parati, G, Pataka, A, Pepin, J, Plywaczewski, R, Rodenstein, D, Roisman, G, Ryan, S, Schulz, R, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Vrints, H, Zielinski, J, Saaresranta T., Hedner J., Bonsignore M. R., Riha R. L., McNicholas W. T., Penzel T., Anttalainen U., Kvamme J. A., Pretl M., Sliwinski P., Verbraecken J., Grote L., Barbe F., Basoglu B., Bielicki P., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Hayes L., Kumor M., Kurki S., Lavie L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., Montserrat J. M., Parati G., Pataka A., Pepin J. L., Plywaczewski R., Rodenstein D., Roisman G., Ryan S., Schulz R., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Vitols A., Vrints H., Zielinski J., Saaresranta, T, Hedner, J, Bonsignore, M, Riha, R, Mcnicholas, W, Penzel, T, Anttalainen, U, Kvamme, J, Pretl, M, Sliwinski, P, Verbraecken, J, Grote, L, Barbe, F, Basoglu, B, Bielicki, P, Dorkova, Z, Escourrou, P, Fietze, I, Esquinas, C, Hayes, L, Kumor, M, Kurki, S, Lavie, L, Lavie, P, Levy, P, Lombardi, C, Marrone, O, Masa, J, Montserrat, J, Parati, G, Pataka, A, Pepin, J, Plywaczewski, R, Rodenstein, D, Roisman, G, Ryan, S, Schulz, R, Tkacova, R, Staats, R, Steiropoulos, P, Varoneckas, G, Vitols, A, Vrints, H, Zielinski, J, Saaresranta T., Hedner J., Bonsignore M. R., Riha R. L., McNicholas W. T., Penzel T., Anttalainen U., Kvamme J. A., Pretl M., Sliwinski P., Verbraecken J., Grote L., Barbe F., Basoglu B., Bielicki P., Dorkova Z., Escourrou P., Fietze I., Esquinas C., Hayes L., Kumor M., Kurki S., Lavie L., Lavie P., Levy P., Lombardi C., Marrone O., Masa J. F., Montserrat J. M., Parati G., Pataka A., Pepin J. L., Plywaczewski R., Rodenstein D., Roisman G., Ryan S., Schulz R., Tkacova R., Staats R., Steiropoulos P., Varoneckas G., Vitols A., Vrints H., and Zielinski J.
Abstract: Background Clinical presentation phenotypes of obstructive sleep apnoea (OSA) and their association with comorbidity as well as impact on adherence to continuous positive airway pressure (CPAP) treatment have not been established. Methods A prospective follow-up cohort of adult patients with OSA (apnoea-hypopnoea index (AHI) of ≥5/h) from 17 European countries and Israel (n = 6,555) was divided into four clinical presentation phenotypes based on daytime symptoms labelled as excessive daytime sleepiness ("EDS") and nocturnal sleep problems other than OSA (labelled as "insomnia"): 1) EDS (daytime+/nighttime-), 2) EDS/insomnia (daytime+/nighttime+), 3) non-EDS/noninsomnia (daytime-/nighttime-), 4) and insomnia (daytime-/nighttime+) phenotype. Results The EDS phenotype comprised 20.7%, the non-EDS/non-insomnia type 25.8%, the EDS/ insomnia type 23.7%, and the insomnia phenotype 29.8% of the entire cohort. Thus, clinical presentation phenotypes with insomnia symptoms were dominant with 53.5%, but only 5.6% had physician diagnosed insomnia. Cardiovascular comorbidity was less prevalent in the EDS and most common in the insomnia phenotype (48.9% vs. 56.8%, p<0.001) despite more severe OSA in the EDS group (AHI 35.0±25.5/h vs. 27.9±22.5/h, p<0.001, respectively). Psychiatric comorbidity was associated with insomnia like OSA phenotypes independent of age, gender and body mass index (HR 1.5 (1.188-1.905), p<0.001). The EDS phenotype tended to associate with higher CPAP usage (22.7 min/d, p = 0.069) when controlled for age, gender, BMI and sleep apnoea severity. Conclusions Phenotypes with insomnia symptoms comprised more than half of OSA patients and were more frequently linked with comorbidity than those with EDS, despite less severe OSA. CPAP usage was slightly higher in phenotypes with EDS.
Published: 2016

47. Neudefinition der Baveno-Klassifikation für obstruktive Schlafapnoe.

Author: Matthes, S, Treml, M, Grote, L, Hedner, J, Ryan, S, Schiza, S, Verbraecken, J, McNicholas, W, Pataka, A, Sliwinski, P, Basoglu, Ö, Bonsignore, M, Pépin, J, and Randerath, W
Published: 2024
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48. Irish thoracic society

Author: Coakley, R., OʼNeill, S., Glynn, P., Finlay, G. A., Russell, K. J., McMahon, K., DʼArcy, E. M., Masterson, J. B., Fitzgerald, M. X., OʼConnor, C. M., OʼDriscoll, L. R., McGarvey, L. P. A., Heaney, L. G., MacMahon, J., Leonard, C., Tormey, V., Burke, C. M., Poulter, L. W., Keatings, V. M., Barnes, P. J., Harty, H. R., Corfield, D. R., Adams, L., Schwartzstein, R. M., Kiely, J. F., Buckley, A., Shiels, P., Deegan, P. C., Maurer, B., McNicholas, W. T., Dunlop, K. A., Martin, B., Riley, M., Shields, M. D., Kilgallen, I., McElvaney, N. G., Cervantes-Laurean, D., Wehr, N., Gabriele, K., Robinson, W., Moss, J., Levine, R. L., Urbach, V., Walsh, D., Harvey, B., McElroy, M. C., Pittet, J F., Allen, L., Wiener-Kroonish, J., Dobbs, L. G., OʼDonnell, D. M., McMahon, K. J., OʼConnor, C., McGuirk, P., Mahon, B., Griffin, F., Mills, K. H. G., Murphy, R., Brijker, F., Mulloy, E., Cohen Tervaert, J. W., Walshe, J., Lowry, R. C., Shepherd, D. R. T., Gamble, L. A., Carton, C., Memon, R., Winter, D., Chan, A., Aherne, T., OʼReilly, P., Harbison, J. A., OʼCallaghan, S., Keane, M., McKenna, M., Woods, S., Lamon, A., Faul, J., Murphy, M., Porszasz, J., Engelen, M. P. K. J., Brundage, B., Wasserman, K., Sweeney, M., OʼRegan, R. G., McLoughlin, P., Honner, V., Sinnott, B., McGrath, D. S., Kiely, J., Cryan, B., Bredin, C. P., Shortt, C., Stack, M., Kelleher, N., McRedmond, J., Mulkerji, N., Keatings, V., Boylan, G. M., Forsythe, P., Cross, L. J. M., Ennis, M., Davern, S., McDonnell, T. J., Kiely, J. L., Lawless, G., Cunningham, S., Lordan, J., Clancy, L., Manning, P., Plunkett, P., Donaghy, D., Musbah, Ben F., Loftus, B. G., Rutherford, R., Watson, S. N. E., Gilmartin, J. J., Henry, M., Mullins, G., and Brennan, N.
Published: 1998
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49. Royal Academy of Medicine in Ireland section of medicine: Proceedings of case reports meeting held in RCPI on November 24th, 1993

Author: Keaveny, A., Mulcahy, H., Stack, W., Kelly, D., O’Donoghue, D. P., Cunnane, G., Pope, F. M., Fitzgetrald, O., Gibson, G., Devlin, J., Murphy, G. M., Buckley, M., O’Morain, C., Donohoe, P., McNicholas, W. T., Todd, A., O’Morain, C., Hayes, F., White, B., and Carney, D. N.
Published: 1994
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50. Royal academy of medicine in Ireland section of medicine: Proceedings of registrar’s prize meeting held in the royal college of physicians, april 28th 1993.

Author: Sheahan, N., Chan, R., Hemeryck, L., Stinson, J., Clancy, L., Feely, J., Fiad, T. M., Culliton, M., Cunningham, S. K., Dunbar, J., McKenna, T. J., Liston, R., Deegan, P. C., McCreery, C., Costello, R., Maurer, B., McNicholas, W. T., Herity, N. A., McCarthy, J., Redmond, H. P., Bouchier-Hayes, D., Donnell, R. O, Gibson, G., O’Grady, T., Carmody, M., Donohoe, J., Walsh, J., Leader, M., Murphy, G. M., Abuaisha, F., Geoghegan, M., and O’Hare, J. A.
Published: 1993
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