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8. Adherence to ESPEN guidelines and associations with postoperative outcomes in upper gastrointestinal cancer resection: results from the multi-centre NOURISH point prevalence study.

Author

Deftereos I., Yeung J.M., Arslan J., Carter V.M., Isenring E., Kiss N., Cardamis A., Dorey A., Ottaway A., Maguire B., Cleeve B., Davis C., Zoanetti C., Gray C., Choong C., Douglas C., Nixon C., Platt D., Quinn E., Simpson E., Hamdorf E., McNamara E., Whelan E., Jegendran G., Moore G., Lockwood G., McNamara J., Corrigan J., Haaksma K., Fox K., Furness K., Cochrane K.W., Huynh K., Lee K.C., Hames N., Hendricks N., Page N., Brooks N., Nevin L., Parfrey L., Putrus E., Pons R., Hoevenaars R., Singh S., McCoy S., Wallin S., Mexias S., Daniells S., Storr T., Robertson T., Brown T., Deftereos I., Yeung J.M., Arslan J., Carter V.M., Isenring E., Kiss N., Cardamis A., Dorey A., Ottaway A., Maguire B., Cleeve B., Davis C., Zoanetti C., Gray C., Choong C., Douglas C., Nixon C., Platt D., Quinn E., Simpson E., Hamdorf E., McNamara E., Whelan E., Jegendran G., Moore G., Lockwood G., McNamara J., Corrigan J., Haaksma K., Fox K., Furness K., Cochrane K.W., Huynh K., Lee K.C., Hames N., Hendricks N., Page N., Brooks N., Nevin L., Parfrey L., Putrus E., Pons R., Hoevenaars R., Singh S., McCoy S., Wallin S., Mexias S., Daniells S., Storr T., Robertson T., and Brown T.

Abstract

Background: Postoperative nutrition support is an essential component of management in upper gastrointestinal (UGI) cancer resection, however there is limited knowledge of current clinical practice. This study aimed to describe the postoperative nutrition support received by patients undergoing UGI cancer resections, assess adherence with ESPEN surgical guideline recommendations, and to investigate differences between oesophageal, gastric and pancreatic surgeries. The secondary aim was to explore the association of adherence with ESPEN guidelines and provision of nutrition support, with surgical complications and length of stay (LOS). Method(s): The NOURISH point prevalence study was conducted between September 2019-June 2020 across 27 Australian tertiary centres. Malnutrition was diagnosed using subjective global assessment. Data on postoperative diet codes, prescription of nutrition support (oral (ONS), enteral (EN), parenteral (PN)) and nutritional adequacy were collected by dietitians for the first 10 days of admission. Fisher's exact test was used to determine differences in nutritional management and adherence to ESPEN guidelines between surgery types. Multivariate regression analysed associations with surgical outcomes. Result(s): Two-hundred participants were included (42% pancreatic, 33% oesophageal, 25% gastric surgery). Overall, only 34.9% (n = 53) met the guideline recommendations that were applicable to them. Early oral intake of fluids or solids (within 24 h post surgery) was initiated for 23.5% (n = 47), whilst ONS/EN/PN was initiated for 49.5% (n = 99). Only 25% of pancreatic surgeries had nutrition support initiated on the first postoperative day compared to 86.4% of oesophageal and 42.0% of gastric surgeries (p < 0.001). In those who were 'nil by mouth', EN/PN were commenced within 24 h for 51.0% (n = 78), with 18.5% and 45.2% for pancreatic and gastric surgeries compared to 86.0% in oesophageal surgeries (p < 0.001). In malnourished patients, 35.7

Published
2022

10. Structure of the VPS34 kinase domain with compound 5

Author

Hu, D.X., primary, Patel, S., additional, Chen, H., additional, Wang, S., additional, Staben, S., additional, Dimitrova, Y.N., additional, Wallweber, H.A., additional, Lee, J.Y., additional, Chan, G.K.Y., additional, Sneeringer, C.J., additional, Prangley, M.S., additional, Moffat, J.G., additional, Wu, C., additional, Schutt, L.K., additional, Salphati, L., additional, Pang, J., additional, McNamara, E., additional, Huang, H., additional, Chen, Y., additional, Wang, Y., additional, Zhao, W., additional, Lim, J., additional, Murthy, A., additional, and Siu, M., additional

Published
2021
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11. Structure of the VPS34 kinase domain with compound 14

Author

Hu, D.X., primary, Patel, S., additional, Chen, H., additional, Wang, S., additional, Staben, S., additional, Dimitrova, Y.N., additional, Wallweber, H.A., additional, Lee, J.Y., additional, Chan, G.K.Y., additional, Sneeringer, C.J., additional, Prangley, M.S., additional, Moffat, J.G., additional, Wu, C., additional, Schutt, L.K., additional, Salphati, L., additional, Pang, J., additional, McNamara, E., additional, Huang, H., additional, Chen, Y., additional, Wang, Y., additional, Zhao, W., additional, Lim, J., additional, Murthy, A., additional, and Siu, M., additional

Published
2021
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12. Adherence to ESPEN guidelines and associations with postoperative outcomes in upper gastrointestinal cancer resection: results from the multi-centre NOURISH point prevalence study.

Author

Deftereos I., Yeung J.M., Arslan J., Carter V.M., Isenring E., Kiss N., Cardamis A., Dorey A., Ottaway A., Maguire B., Cleeve B., Davis C., Zoanetti C., Gray C., Choong C., Douglas C., Nixon C., Platt D., Quinn E., Simpson E., Hamdorf E., McNamara E., Whelan E., Jegendran G., Moore G., Lockwood G., McNamara J., Corrigan J., Haaksma K., Fox K., Furness K., Cochrane K.W., Huynh K., Lee K.C., Hames N., Hendricks N., Page N., Brooks N., Nevin L., Parfrey L., Putrus E., Pons R., Hoevenaars R., Singh S., McCoy S., Wallin S., Mexias S., Daniells S., Storr T., Robertson T., Brown T., Deftereos I., Yeung J.M., Arslan J., Carter V.M., Isenring E., Kiss N., Cardamis A., Dorey A., Ottaway A., Maguire B., Cleeve B., Davis C., Zoanetti C., Gray C., Choong C., Douglas C., Nixon C., Platt D., Quinn E., Simpson E., Hamdorf E., McNamara E., Whelan E., Jegendran G., Moore G., Lockwood G., McNamara J., Corrigan J., Haaksma K., Fox K., Furness K., Cochrane K.W., Huynh K., Lee K.C., Hames N., Hendricks N., Page N., Brooks N., Nevin L., Parfrey L., Putrus E., Pons R., Hoevenaars R., Singh S., McCoy S., Wallin S., Mexias S., Daniells S., Storr T., Robertson T., and Brown T.

Abstract

Background: Postoperative nutrition support is an essential component of management in upper gastrointestinal (UGI) cancer resection, however there is limited knowledge of current clinical practice. This study aimed to describe the postoperative nutrition support received by patients undergoing UGI cancer resections, assess adherence with ESPEN surgical guideline recommendations, and to investigate differences between oesophageal, gastric and pancreatic surgeries. The secondary aim was to explore the association of adherence with ESPEN guidelines and provision of nutrition support, with surgical complications and length of stay (LOS). Method(s): The NOURISH point prevalence study was conducted between September 2019-June 2020 across 27 Australian tertiary centres. Malnutrition was diagnosed using subjective global assessment. Data on postoperative diet codes, prescription of nutrition support (oral (ONS), enteral (EN), parenteral (PN)) and nutritional adequacy were collected by dietitians for the first 10 days of admission. Fisher's exact test was used to determine differences in nutritional management and adherence to ESPEN guidelines between surgery types. Multivariate regression analysed associations with surgical outcomes. Result(s): Two-hundred participants were included (42% pancreatic, 33% oesophageal, 25% gastric surgery). Overall, only 34.9% (n = 53) met the guideline recommendations that were applicable to them. Early oral intake of fluids or solids (within 24 h post surgery) was initiated for 23.5% (n = 47), whilst ONS/EN/PN was initiated for 49.5% (n = 99). Only 25% of pancreatic surgeries had nutrition support initiated on the first postoperative day compared to 86.4% of oesophageal and 42.0% of gastric surgeries (p < 0.001). In those who were 'nil by mouth', EN/PN were commenced within 24 h for 51.0% (n = 78), with 18.5% and 45.2% for pancreatic and gastric surgeries compared to 86.0% in oesophageal surgeries (p < 0.001). In malnourished patients, 35.7

Published
2021

13. Threat of COVID-19 impacting on a quaternary healthcare service: a retrospective cohort study of administrative data

Author

McNamara, E, Saxon, L, Bond, K, Campbell, BC, Douglass, J, Dutch, MJ, Grigg, L, Johnson, D, Knott, JC, Koye, DN, Putland, M, Read, DJ, Smith, B, Thomson, BN, Williamson, DA, Tong, SY, Fazio, TN, McNamara, E, Saxon, L, Bond, K, Campbell, BC, Douglass, J, Dutch, MJ, Grigg, L, Johnson, D, Knott, JC, Koye, DN, Putland, M, Read, DJ, Smith, B, Thomson, BN, Williamson, DA, Tong, SY, and Fazio, TN

Abstract

OBJECTIVES: The threat of a pandemic, over and above the disease itself, may have significant and broad effects on a healthcare system. We aimed to describe the impact of the SARS-CoV-2 pandemic (during a relatively low transmission period) and associated societal restrictions on presentations, admissions and outpatient visits. DESIGN: We compared hospital activity in 2020 with the preceding 5 years, 2015-2019, using a retrospective cohort study design. SETTING: Quaternary hospital in Melbourne, Australia. PARTICIPANTS: Emergency department presentations, hospital admissions and outpatient visits from 1 January 2015 to 30 June 2020, n=896 934 episodes of care. INTERVENTION: In Australia, the initial peak COVID-19 phase was March-April. PRIMARY AND SECONDARY OUTCOME MEASURES: Separate linear regression models were fitted to estimate the impact of the pandemic on the number, type and severity of emergency presentations, hospital admissions and outpatient visits. RESULTS: During the peak COVID-19 phase (March and April 2020), there were marked reductions in emergency presentations (10 389 observed vs 14 678 expected; 29% reduction; p<0.05) and hospital admissions (5972 observed vs 8368 expected; 28% reduction; p<0.05). Stroke (114 observed vs 177 expected; 35% reduction; p<0.05) and trauma (1336 observed vs 1764 expected; 24% reduction; p<0.05) presentations decreased; acute myocardial infarctions were unchanged. There was an increase in the proportion of hospital admissions requiring intensive care (7.0% observed vs 6.0% expected; p<0.05) or resulting in death (2.2% observed vs 1.5% expected; p<0.05). Outpatient attendances remained similar (30 267 observed vs 31 980 expected; 5% reduction; not significant) but telephone/telehealth consultations increased from 2.5% to 45% (p<0.05) of total consultations. CONCLUSIONS: Although case numbers of COVID-19 were relatively low in Australia during the first 6 months of 2020, the impact on hospital activity was profound.

Published
2021

15. Congenital myopathies 1 – Nemaline

Author

Clayton, J., McNamara, E., Goullee, H., Conijn, S., Muthsam, K., Musk, G., Coote, D., Kijas, J., Testa, A., Taylor, R., O'Hara, M., Groth, D., Ottenheijm, C., Ravenscroft, G., Laing, N., Nowak, K., Clayton, J., McNamara, E., Goullee, H., Conijn, S., Muthsam, K., Musk, G., Coote, D., Kijas, J., Testa, A., Taylor, R., O'Hara, M., Groth, D., Ottenheijm, C., Ravenscroft, G., Laing, N., and Nowak, K.

Abstract

Ovine congenital progressive muscular dystrophy (OCPMD) was first described in Merino sheep flocks in Queensland and Western Australia (WA) in the 1960s and 70s. The most prominent feature of the disease is a distinctive gait with stiffness of the hind limbs that can be seen as early as three weeks after birth. The disease is progressive. Histopathological examination had revealed dystrophic changes specifically in slow myofibres, while electron microscopy had demonstrated abundant nemaline bodies. Therefore, it was never certain whether the disease was a dystrophy or a nemaline myopathy with dystrophic features. In this study, we performed whole genome sequencing of WA OCPMD sheep and identified a single base deletion at the splice donor site (+1) of intron 13 of the slow myofibre-specific TNNT1 gene (KT218690 c.614+1delG). All affected sheep were homozygous for this variant. Examination of TNNT1 splicing by RT-PCR showed intron retention and premature termination, which disrupts the highly conserved 14 amino acid C-terminus. The variant did not reduce TNNT1 protein levels or affect its localization but impaired its ability to modulate muscle contraction in response to Ca2+ levels. Identification of the causative variant in TNNT1 finally clarifies that the WA OCPMD sheep is in fact a large animal model of nemaline myopathy with dystrophic features. This model could now be used for testing molecular or gene therapies.

Published
2020

16. CONGENITAL MYOPATHIES 1 – NEMALINE

Author

Clayton, J., primary, McNamara, E., additional, Goullee, H., additional, Conijn, S., additional, Muthsam, K., additional, Musk, G., additional, Coote, D., additional, Kijas, J., additional, Testa, A., additional, Taylor, R., additional, O'Hara, M., additional, Groth, D., additional, Ottenheijm, C., additional, Ravenscroft, G., additional, Laing, N., additional, and Nowak, K., additional

Published
2020
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17. National scientific medical meeting 1997 abstracts

Author

Willison, H. J., Lastovica, A. J., Prendergast, M. M., Moran, A. P., Walsh, C., Flitcroft, I., Eustace, P., McMahon, C., Smith, J., Smith, O. P., Lakshmandass, G., Taylor, M. R. H., Holland, C. V., Cox, D., Good, B., Kearns, G. M., Gaffney, P., Shark, K., Frauenshuh, M., Ortmann, W., Messner, R., King, R., Rich, S., Behrens, T., Mahmud, N., Molloy, A., McPartlin, J., Scott, J. M., Weir, D. G., Walsh, K. M., Thorburn, D., Mills, P., Morris, A. J., Good, T., Cameron, S., McCruden, E. A. B., Bennett, M. W., O’Connell, J., Brady, C., Roche, D., Collins, J. K., Shanahan, F., O’Sullivant, G. C., Henry, M., Koston, S., McMahon, K., MacNee, W., FitzGerald, M. X., O’Connor, C. M., McGonagle, D., Gibbon, W., O’Connor, P., Emery, P., Murphy, M., Watson, R., Casey, E., Naidu, E., Murphy, M., Watson, R., Barnes, L., McCann, S., Murphy, M., Watson, R., Barnes, L., Sweeney, E., Barrett, E. J., Graham, H., Cunningham, R. T., Johnston, C. F., Curry, W. J., Buchanan, K. D., Courtney, C. H., McAllister, A. S., McCance, D. R., Hadden, D. R., Bell, P. M., Leslie, H., Sheridan, B., Atkinson, A. B., Kilbane, M. T., Smith, D. F., Murray, M. J., Shering, S. G., McDermott, E. W. M., O’Higgins, N. J., Smyth, P. P. A., McEneny, J., Trimble, E. R., Young, I. S., Sharpe, P., Mercer, C., McMaster, D., Young, I. S., Evans, A. E., Young, I. S., Cundick, J., Hasselwander, O., McMaster, D., McGeough, J., Savage, D., Maxwell, A. P., Evans, A. E., Kee, F., Larkin, C. J., Watson, R. G. P., Johnston, C., Ardill, J. E. S., Buchanan, K. D., McNamara, D. A., Walsh, T. N., Bouchier-Hayes, D. J., Madden, C., Timon, C., Gardiner, N., Lawler, M., O’Riordan, J., Duggan, C., McCann, S. R., Gowing, H., Braakman, E., Lawler, M., Byrne, C., Martens, A. C. M., Hagenbeek, A., McCann, S. R., Kinsella, N., Cusack, S., Lawler, M., Baker, H., White, B., Smith, O. P., Lawler, M., Gardiner, N., Molloy, K., Gowing, H., Wogan, A., McCann, S. R., McElwaine, S., Lawler, M., Hollywood, D., McCann, S. R., Mcmahon, C., Merry, C., Ryan, M., Smith, O., Mulcahy, F. M., Murphy, C., Briones, J., Gardiner, N., McCann, S. R., Lawler, M., White, B., Lawler, M., Cusack, S., Kinsella, N., Smith, O. P., Lavin, P., McCaffrey, M., Gillen, P., White, B., Smith, O. P., Thompson, L., Lalloz, M., Layton, M., Barnes, L., Corish, C., Kennedy, N. P., Flood, P., Mulligan, S., McNamara, E., Kennedy, N. P., Flood, P., Mathias, P. M., Ball, E., Duiculescu, D., Calistru, P., O’Gorman, N., Kennedy, N. P., Abuzakouk, M., Feighery, C., Brannigan, M., Pender, S., Keeling, F., Varghese, J., Lee, M., Colreavy, M., Gaffney, R., Hone, S., Herzig, M., Walsh, M., Dolan, C., Wogan, A., Lawler, M., McCann, S. R., Hollywood, D., Donovan, D., Harmey, J., Bouchier-Hayes, D. J., Haverty, A., Wang, J. H., Harmey, J. H., Redmond, H. P., Bouchier-Hayes, D. J., McGreal, G., Shering, S. G., Moriarty, M. J., Shortt, A., Kilbane, M. T., Smith, D. F., McDermott, E. W. M., O’Higgins, N. J., Smyth, P. P. A., McNamara, D. A., Harmey, J., Wang, J. H., Donovan, D., Walsh, T. N., Bouchier-Hayes, D. J., Kay, E., Pidgeon, G., Harmey, J., McNamara, D. A., Bouchier-Hayes, D. J., Dunne, P., Lambkin, H., Russell, J. M., O’Neill, A. J., Dunne, B. M., O’Donovan, M., Lawler, M., Gaffney, E. F., Gillan, J. E., Cotter, T. G., Horan, J., Jones, D., Biswas, S. K., Mulkerrin, E. C., Brady, H., O’Donnell, J., Neary, J., Healy, E., Watson, A., Keogh, B., Ryan, M., Cassidy, C., Ward, S., Stokes, E., Keoghan, F., Barrett, A., O’Connell, P., Ryall, N., O’Connell, P. A., Jenkinson, A., O’Brien, T., O’Connell, P. G., Harrison, R., Barrett, T., Bailey, D. M. D., Butler, A., Barton, D. E., Byrne, C., McElwaine, S., McCann, S. R., Lawler, M., Cusack, S., Lawler, M., White, B., Smith, O. P., Daly, G., Gill, M., Heron, S., Hawi, Z., Fitzgerald, M., Hawi, Z., Mynett-Johnson, L., Shiels, D., Kendler, K., McKeon, P., Gill, M., Straub, R., Walsh, D., Ryan, F., Barton, D. E., McCabe, D., Murphy, R., Segurado, R., Mulcahy, T., Larson, B., Comerford, C., O’Connell, R., O’Mahony, E., Gill, M., Donnelly, J., Minahan, F., O’Neill, D., Farrell, Z., O’Neill, D., Jones, D., Horan, J., Glynn, C., Biswas, S. K., Mulkerrin, E., Brady, H., Lennox, S. E., Murphy, A., Rea, I. M., McNulty, H., McMeel, C., O’Neill, D., McEvoy, H., Freaney, R., McKenna, M. J., Crowe, M., Keating, D., Colreavy, M., Hone, S., Norman, G., Widda, S., Viani, L., Galvin, Nolan, C. M., Hardiman, O., Hardiman, O., Brett, F., Droogan, O., Gallagher, P., Harmey, M., King, M., Murphy, J., Perryrnan, R., Sukumaran, S., Walsh, J., Farrell, M. A., Hughes, G., Cunningham, C., Walsh, J. B., Coakley, D., O’Neill, D., Hurson, M., Flood, P., McMonagle, P., Hardiman, O., Ryan, F., O’Sullivan, S., Merry, C., Dodd, P., Redmond, J., Mulcahy, F. M., Browne, R., Keating, S., O’Connor, J., Cassidy, B. P., Smyth, R., Sheppard, N. P., Cullivan, R., Crown, J., Walsh, N., Denihan, A., Bruce, I., Radic, A., Coakley, D., Lawlor, B. A., Bridges, P. K., O’Doherty, M., Farrington, A., O’Doherty, M., Farragher, B., Fahy, S., Kelly, R., Carey, T., Owens, J., Gallagher, O., Sloan, D., McDonough, C., Casey, P., Horgan, A., Elneihum, A., O’Neill, C., McMonagle, T., Quinn, J., Meagher, D., Murphy, P., Kinsella, A., Mullaney, J., Waddington, J. L., Rooney, S., Rooney, S., Bamford, L., Sloan, D., O’Connor, J. J., Franklin, R., O’Brien, K., Fitzpatrick, G., Laffey, J. G., Boylan, J. F., Laffey, J., Coleman, M., Boylan, J., Laffey, J. G., McShane, A. J., Boylan, J. F., Loughrey, J. P. R., Gardiner, J., McGinley, J., Leonard, I., Carey, M., Neligan, P., O’Rourke, J., Cunningham, A., Fennessy, F., Kelly, C., Bouchier-Hayes, D., Fennessy, F., Wang, J. H., Kelly, C., Bouchier-Hayes, D., Fennessy, F., Wang, J. H., Kelly, C., Bouchier-Hayes, D. J., Kellett, J., Laffey, J., Murphy, D., Regan, J., O’Keeffe, D., Mahmud, A., Hemeryck, L., Feely, J., Mahmud, A., Hemeryck, L., Hall, M., Feely, J., Menown, I. B. A., Mathew, T. P., Nesbitt, G. S., Syme, M., Young, I. S., Adgey, A. A. J., Menown, I. B. A., Turtle, F., Allen, J., Anderson, J., Adgey, A. A. J., O’Hanlon, R., Codd, M. B., Walkin, S., McCann, H. A., Sugrue, D. D., Rasheed, A. M., Chen, G., Kelly, C., Bouchier-Hayes, D. J., Leahy, A., Rasheed, A. M., Kay, E., Jina, S., Bouchier-Hayes, D. J., Leahy, A., McDowell, I., Rasheed, A. M., Wang, J. H., Wo, Q., Kelly, C., Bouchier-Hayes, D. J., Leahy, A., Shuhaibar, M. N., McGovern, E., Turtle, F., Menown, I. B. A., Manoharan, G., Kirkpatrick, R., Campbell, N. P. S., Walkin, S., Codd, M. B., O’Hanlon, R., McCarthy, C., McCann, H. A., Sugrue, D. D., Wen, Y., Killalea, S., Hall, M., Hemeryck, L., Feely, J., Fahy, C. J., Griffith, A., McGinley, J., McCabe, D., Fraser, A., Casey, E., Ryan, T., Murphy, R., Browne, M., Fenton, J., Hughes, J., Timon, C. I., Fenton, J., Curran, A., Smyth, D., Viani, L., Walsh, M., Hughes, J. P., Fenton, J., Lee, P., Kelly, A., Timon, C. I., Hughes, J. P., Fenton, J., Shine, N., Blayney, A., McShane, D. P., Timon, C. I., Hussey, J., Howlett, M., Langton, A., McEvoy, A., Slevin, J., Fitzpatrick, C., Turner, M. J., Enright, F., Goggin, N., Costigan, C., Duff, D., Osizlok, P., Wood, F., Watson, R., Fitzsimons, R. B., Flanagan, N., Enright, F., Barnes, L., Watson, R., Molloy, E., Griffin, E., Deasy, P. F., Sheridan, M., White, M. J., Moore, R., Gray, A., Hill, J., Glasgow, J. F. T., Middleton, B., Slattery, D., Donoghue, V., McMahon, A., Murphy, J., Slattery, D., McCarthy, A., Oslislok, P., Duff, D., Colreavy, M., Keogh, I., Hone, S., Walsh, M., Henry, M., Koston, S., McMahon, K., MacNee, W., FitzGerald, M. X., O’Connor, C. M., Russell, K. J., Henry, M., Fitzgerald, M. X., O’Connor, C. M., Kavanagh, P. V., McNamara, S. M., Feely, J., Barry, M., O’Brien, J. E., McCormick, P., Molony, C., Doyle, R. M., Walsh, J. B., Coakley, D., Codd, M. B., O’Connell, P. R., Dowey, L. C., McGlynn, H., Thurnham, D. I., Elborn, S. J., Flynn, L., Carton, J., Byrne, B., O’Farrelly, C., Kelehan, P., O’Herlihy, C., O’Hara, A. M., Moran, A. P., Orren, A., Fernie, B. A., Merry, C., Clarke, S., Courtney, G., de Gascun, C., Mulcahy, F. M., Merry, C., Ryan, M., Barry, M., Mulcahy, F. M., Merry, C., Ryan, M., Barry, M., Mulcahy, F. M., Byrne, M., Moylett, E., Murphy, H., Butler, K., Nourse, C., Thaker, H., Barry, C., Russell, J., Sheehan, G., Boyle, B., Hone, R., Conboy, B., Butler, C., Moris, D., Cormican, M., Flynn, J., McCormack, O., Corbally, N., Murray, A., Kirrane, S., O’Keane, C., Hone, R., Lynch, S. M., Cryan, B., Whyte, D., Morris, D., Butler, C., Cormican, M., Flynn, J., Corbett-Feeney, G., Murray, A., Corbally, N., Hone, R., Mackle, T., Colreavy, M., Perkins, J., Saidlear, C., Young, A., Eustace, P., Wrigley, M., Clifford, J., Waddington, J. L., Tighe, O., Croke, D. T., Drago, J., Sibley, D. R., Feely, J., Kelly, A., Carvalho, M., Hennessy, M., Kelly, M., Feely, J., Hughes, C., Hanlon, M., Feely, J., Sabra, K., Keane, T., Egan, D., Ryan, M., Maerry, C., Ryan, M., Barry, M., Mulcahy, F. M., Maerry, C., Ryan, M., Barry, M., Mulcahy, F. M., Sharma, S. C., Williams, D., Kelly, A., Carvalho, M., Feely, J., Williams, D., Kelly, A., Carvalho, M., Feely, J., Codd, M. B., Mahon, N. G., McCann, H. A., Sugrue, D. D., Sayers, G. M., Johnson, Z., McNamara, S. M., Kavanagh, P. V., and Feely, J.

Published
1998
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19. National Scientific Medical Meeting 1994 Abstracts

Author

Carson, K. D., Grimes, S. B., McGinley, J. M., Thornton, M. T., Mulhall, J., Bourke, A. M., McCrory, C., Marsh, B., Hone, R., Phelan, D., White, M., Fabry, J., Hughes, D., Carson, K., Donnelly, M., Shanahan, E., Fitzpatrick, G. J., Bourke, M., Warde, D., Buggy, D., Hughes, N., Taylor, A., Dowd, N., Markham, T., Blunnie, W., Nicholson, G., O’Leary, E., Cunningham, A. J., Dwyer, R., McMechan, S., Cullen, C., Dempsey, G., Wright, G., MacKenzie, G., Anderson, J., Adgey, J., Walsh, M., O’Callaghan, P., Graham, I., O’Hare, J. A., Geoghegan, M., Iman, N., Shah, P., Chander, R., Lavin, F., Daly, K., Johnston, P. W., Imam, Z., Adgey, A. A. J., Rusk, R. A., Richardson, S. G., Hale, A., Kinsella, B. M., FitzGerald, G. A., King, G., Crean, P., Gearty, G., Cawley, T., Docherty, J. R., Geraghty, J., Osborne, H., Upton, J., D’Arcy, G., Stinson, J., Cooke, T., Colgan, M. P., Hall, M., Tyrrell, J., Gaffney, K., Grouden, M., Moore, D. J., Shanik, G., Feely, J., Delanty, N., Reilly, M., Lawson, J. A., Fitzgerald, D. J., Reilly, M. P., McAdam, B. F., Bergin, C., Walshe, M. J., Herity, N. A., Allen, J. D., Silke, B., Singh, H. P., O’Neill, S., Hargrove, M., Coleman, E., Shorten, E., Aherne, T., Kelly, B. E., Hill, D. H., McIlrath, E., Morrow, B. C., Lavery, G. G., Blackwood, B., Fee, J. P. H., Kevin, L., Doran, M., Tansey, D., Boylan, I., McShane, A. J., O’Reilly, G., Tuohy, B., Grainger, P., Larkin, T., Mahady, J., Malone, J., Condon, C., Donoghue, T., O’Leary, J., Lyons, J. F., Tay, Y. K., Tham, S. N., Khoo Tan, H. S., Gibson, G., O’Grady, A., Leader, M., Walshe, J., Carmody, M., Donohoe, J., Murphy, G. M., O’Connor, W., Barnes, L., Watson, R., Darby, C., O’Moore, R., Mulcahy, F., O’Toole, E., O’Briain, D. S., Young, M. M., Buckley, D., Healy, E., Rogers, S., Ni Scannlain, N., McKenna, M. J., McBrinn, Y., Murray, B., Freaney, R., Barrett, E., Razza, Q., Abuaisha, F., Powell, D., Murray, T. M., Powell, A. M., O’Mongain, E., O’Neill, J., Kernan, R. P., O’Connor, P., Clarke, D., Fearon, U., Cunningham, S. K., McKenna, T. J., Hayes, F., Heffernan, A., Sheahan, K., Harper, R., Johnston, G. D., Atkinson, A. B., Sheridan, B., Bell, P. M., Heaney, A. P., Loughrey, G., McCance, D. R., Hadden, D. R., Kennedy, A. L., McNamara, P., O’Shaughnessy, C., Loughrey, H. C., Reid, I., Teahan, S., Caldwell, M., Walsh, T. N., McSweeney, J., Hennessy, T. P., Caldwell, M. T. P., Byrne, P. J., Hennessy, T. P. J., El-Magbri, A. A., Stevens, F. M., O’Sullivan, R., McCarthy, C. F., Laundon, J., Heneghan, M. A., Kearns, M., Goulding, J., Egan, E. L., McMahon, B. P., Hegarty, F., Malone, J. F., Merriman, R., MacMathuna, P., Crowe, J., Lennon, J., White, P., Clarke, E., Prabhakar, M. C., Ryan, E., Graham, D., Yeoh, P. L., Kelly, P., McKeogh, D., O’Keane, C., Kitching, A., Mulligan, E., Gorey, T. F., Mahmud, N., O’Connell, M., Goggins, M., Keeling, P. W. N., Weir, D. G., Kelleher, D., McDonald, G. S. A., Maguire, D., O’Sullivan, G., Harvey, B., Cherukuri, A., McGrath, J. P., Timon, C., Lawlor, P., O’Shea, J., Buckley, M., English, L., Walsh, T., O’Morain, C., Lavelle, S. M., Kanagaratnam, B., Harding, B., Murphy, B., Kavanagh, J., Kerr, D., Lavelle, E., O’Gorman, T., Liston, S., Fitzpatrick, C., Fitzpatrick, P., Turner, M., Murphy, A. W., Cafferty, D., Dowling, J., Bury, G., Kaf Al-Ghazal, S., Zimmermann, E., O’Donoghue, J., McCann, J., Sheehan, C., Boissel, L., Lynch, M., Cryan, B., Fanning, S., O’Meara, D., Fennell, J., Byrne, P. M., Lyons, D., Mulcahy, R., Pooransingh, A., Walsh, J. B., Coakley, D., O’Neill, D., Ryall, N., Connolly, P., Namushi, R., Lawler, M., Locasciulli, A., Bacigalupo, A., Humphries, P., McCann, S. R., Pamphilon, D., Reidy, M., Madden, M., Finch, T., Borton, M., Barnes, C. A., Lawlor, S. E., Gardiner, N., Egan, L. J., Orren, A., Doherty, J., Curran, C., O’Hanlon, D., Kent, P., Kerin, M., Maher, D., Given, H. F., Lynch, S., McManus, R., O’Farrelly, C., Madrigal, L., Feighery, C., O’Donoghue, D., Whelan, C. A., Rea, I. M., Stewart, M., Campbell, P., Alexander, H. D., Crockard, A. D., Morris, T. C. M., Maguire, H., Davidson, F., Kaminski, G. Z., Butler, K., Hillary, I. B., Parfrey, N. A., Crowley, B., McCreary, C., Keane, C., O’Reilly, M., Goh, J., Kennedy, M., Fitzgerald, M., Scott, T., Murphy, S., Hildebrand, J., Holliman, R., Smith, C., Kengasu, K., Riain, U. Ni, Cormican, M., Flynn, J., Glennon, M., Smith, T., Whyte, D., Keane, C. T., Barry, T., Noone, D., Maher, M., Dawson, M., Gilmartin, J. J., Gannon, F., Eljamel, M. S., Allcut, D., Pidgeon, C. N., Phillips, J., Rawluk, D., Young, S., Toland, J., Deveney, A. M., Waddington, J. L., O’Brien, D. P., Hickey, A., Maguire, E., Phillips, J. P., Al-Ansari, N., Cunney, R., Smyth, E., Sharif, S., Eljamel, M., Pidgeon, C., Maguire, E. A., Burke, E. T., Staunton, H., O’Riordan, J. I., Hutchinson, M., Norton, M., McGeeney, B., O’Connor, M., Redmond, J. M. T., Feely, S., Boyle, G., McAuliffe, F., Foley, M., Kelehan, P., Murphy, J., Greene, R. A., Higgins, J., Darling, M., Byrne, P., Kondaveeti, U., Gordon, A. C., Hennelly, B., Woods, T., Harrison, R. F., Geary, M., Sutherst, J. R., Turner, M. J., DeLancey, J. O. L, Donnelly, V. S., O’Connell, P. R., O’Herlihy, C., Barry-Kinsella, C., Sharma, S. C., Drury, L., Lewis, S., Stratton, J., Ni Scanaill, S., Stuart, B., Hickey, K., Coulter-Smith, S., Moloney, A., Robson, M. S., Murphy, M., Keane, D., Stronge, J., Boylan, P., Gonsalves, R., Blankson, S., McGuinness, E., Sheppard, B., Bonnar, J., MacDonagh-White, C. M., Kelleher, C. C., Newell, J., White, O., Young, Y., Hallahan, C., Carroll, K., Tipton, K., McDermott, E. W., Reynolds, J. V., Nolan, N., McCann, A., Rafferty, R., Sweeney, P., Carney, D., O’Higgins, N. J., Duffy, M. J., Grimes, H., Gallagher, S., O’Hanlon, D. M., Strattan, J., Lenehan, P., Robson, M., Cusack, Y. A., O’Riordain, D., Mercer, P. M., Smyth, P. P. A., Gallagher, H. J., Moule, B., Cooke, T. G., McArdle, C. S., Burke, C., Vance, A., Saidtéar, C., Early, A., Eustace, P., Maguire, L., Cullinane, A. B. P., Prosser, E. S., Coca-Prados, M., Harvey, B. J., Saidléar, C., Orwa, S., Fitzsimons, R. B., Bradley, O., Hogan, M., Zimmerman, L., Wang, J., Kuliszewski, M., Liu, J., Post, M., Premkumar, Conran, M. J., Nolan, G., Duff, D., Oslizlok, P., Denham, B., O’Connell, P. A, Birthistle, K., Hitchcock, R., Carrington, D., Calvert, S., Holmes, K., Smith, D. F., Hetherton, A. M., Mott, M. G., Oakhill, A., Foreman, N., Foot, A., Dixon, J., Walsh, S., Mortimer, G., O’Sullivan, C., Kilgallen, C. M., Sweeney, E. C., Brayden, D. J., Kelly, J. G., McCormack, P. M. E., Hayes, C., Johnson, Z., Dack, P., Hosseini, J., O’Connell, T., Hemeryck, L., Condren, L., McCormack, P., McAdam, B., Lawson, J., Keimowitz, R., O’Leary, A., Pilkington, R., Adebayo, G. I., Gaffney, P., McGettigan, P., McManus, J., O’Shea, B., Wen, Y., Killalea, S., Golden, J., Swanwick, G., Clare, A. W., Mulvany, F., Byrne, M., O’Callaghan, E., Byrne, H., Cannon, N., Kinsella, T., Cassidy, B., Shepard, N., Horgan, R., Larkin, C., Cotter, D., Coffey, V. P., Sham, P. C., Murray, L. H., Lane, A., Kinsella, A., Murphy, P., Colgan, K., Sloan, D., Gilligan, P., McEnri, J., Ennis, J. T., Stack, J., Corcoran, E., Walsh, D., Thornton, L., Temperley, I., Lawlor, E., Tobin, A., Hillary, I., Nelson, H. G., Martin, M., Ryan, F. M., Christie, M. A., Murray, D., Keane, E., Holmes, E., Hollyer, J., Strangeways, J., Foster, P., Stanwell-Smith, R., Griffin, E., Conlon, T., Hayes, E., Clarke, T., Fogarty, J., Moloney, A. C., Killeen, P., Farrell, S., Clancy, L., Hynes, M., Conlon, C., Foley-Nolan, C., Shelley, E., Collins, C., McNamara, E., Hayes, B., Creamer, E., LaFoy, M., Costigan, P., Al fnAnsari, N., Cunney, R. J., Smyth, E. G., Johnson, H., McQuoid, G., Gilmer, B., Browne, G., Keogh, J. A. B., Jefferson, A, Smith, M., Hennessy, S., Burke, C. M., Sreenan, S., Power, C. K., Pathmakanthan, S., Poulter, L. W., Chan, A., Sheehan, M., Maguire, M., O’Connor, C. M., FitzGerald, M. X., Southey, A., Costello, C. M., McQuaid, K., Urbach, V., Thomas, S., Horwitz, E. R., Mulherin, D., FitzGerald, O., Bresnihan, B., Kirk, G., Veale, D. J., Belch, J. J. F., Mofidi, A., Mofidi, R., Quigley, C., McLaren, M., Veale, D., D’Arrigo, C., Couto, J. Candal, Woof, J., Greer, M., Cree, I., Belch, J., Hone, S., Fenton, J., Hamilton, S., and McShane, D.

Published
1994
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20. Variable outcomes of human heart attack recapitulated in genetically diverse mice.

Author

Salimova, E, Nowak, KJ, Estrada, AC, Furtado, MB, McNamara, E, Nguyen, Q, Balmer, L, Preuss, C, Holmes, JW, Ramialison, M, Morahan, G, Rosenthal, NA, Salimova, E, Nowak, KJ, Estrada, AC, Furtado, MB, McNamara, E, Nguyen, Q, Balmer, L, Preuss, C, Holmes, JW, Ramialison, M, Morahan, G, and Rosenthal, NA

Abstract

Clinical variation in patient responses to myocardial infarction (MI) has been difficult to model in laboratory animals. To assess the genetic basis of variation in outcomes after heart attack, we characterized responses to acute MI in the Collaborative Cross (CC), a multi-parental panel of genetically diverse mouse strains. Striking differences in post-MI functional, morphological, and myocardial scar features were detected across 32 CC founder and recombinant inbred strains. Transcriptomic analyses revealed a plausible link between increased intrinsic cardiac oxidative phosphorylation levels and MI-induced heart failure. The emergence of significant quantitative trait loci for several post-MI traits indicates that utilizing CC strains is a valid approach for gene network discovery in cardiovascular disease, enabling more accurate clinical risk assessment and prediction.

Published
2019

24. Selected abstracts

Author

Corkery, P. P., Leek, B. F., Caulfield, B., Garrett, M., Gormley, J. P., OʼDonnell, P. M., Kennedy, N., Sayers, K., Stokes, E., Bresnihan, B., Fitzgerald, O., McGarvey, M. A., Tonra, M., Hooper, A. C. B., Barry, J., Maurer, B., Hussey, J., Gormley, J., Noble, J. G., Alves-Guerreiro, J., Lowe, A. S., Walsh, D. M., NicNiocaill, B., Harte, M., OʼConnor, W. T., OʼHara, A. M., Orren, A., Moran, A. P., Hardiman, D. A., Lee, T. C., Croke, D. T., Tolan, R., McBennett, S., Warmington, S., McGuire, M., Bradford, A., OʼHare, T., MacDermott, M., Lynch, F., OʼRegan, R. G., McLoughlin, P., Quinn, T., Ryan, J. P., Pickering, M., Campion, D. P., Jones, J. F. X., Ryan, S., McNicholas, W. T., Nolan, P., Doyle, F. J., Rackard, S. M., Beddy, P., Campbell, V. A., Bakhle, Y. S., Bell, C., Usher, C., Chan, L., Keenan, A. K., McQuaid, K. E., Cullen, V. C., Smith, E. M., Kelly, A., Lynch, M. A., Freir, D. B., Holscher, C., Herron, C. E., Pearson, H. A., Curran, B. P., OʼConnor, J. J., Quinn, A., McHale, J., Moriarty, D., OʼConnor, J., Glennon, J. C., Van Vliet, B. J., Long, S. K., Kruse, C., Gallagher, H. C., Bacon, C. L., Boland, B., Griffin, A. M., Preisler, J., OʼBrien, L., Regan, C. M., Hurley, S., Kearney, P. J., Slevin, J., Barry-Kinsella, C., Ryan, C. A., Kllleen, O., Glllan, J., Clarke, T., Matthews, T., Corcoran, D., Dunn, E., Geary, M., OʼHerlihy, C., Keane, D., OʼLeary, M. J., Morrison, J. J., Ryan, E., Gorman, W. A., Bourke, A., Larkin, J., Mayes, C., Jenkins, J., Ryan, M., Lalchandani, S., Sheil, O., Lynch, N., Costigan, C., Murphy, J. F., Bhatia, R., Foran, A., Donohue, V., McParland, P., LaSjaunais, P., Rodesch, G., McGinn, M., McAloon, J., OʼLeary, M., Astbury, K., Harmon, D., Sharkey, A., Gaffney, G., OʼRegan, G., McMahon, C., Murray, D., McDermott, C., Woolhead, E., Gillan, J., Cartmill, J. L., Harper, M. A., Al-Shabibi, N., Hanahoe, M., Wingfield, M., Larkin, J. A. M., Bell, A. H., McClure, B. G., Sweeney, L., Martin, D. H., OʼDonoghue, P., Davoren, A., Lucas, G. F., McKiernan, J., Gallagher, D. M. T., Dunne, K. P., Fulena, O., Sheridan, M., Griffin, E., White, M., Deasy, P., OʼRiordan, M., OʼGorman, C., Mongan, C., McCafferkey, M., Henry, G., McKenna, P., OʼMalley, A., Devaney, D., Kelleghan, P., Mooney, E. E., Gillan, J. E., Fitzpatrick, M., McQuillan, K., Heffron, C., Hodnett, P., Curtain, A., OʼConnor, T. C. F., Connell, T. G., Waldron, D., Gorman, W., Bolger, T., OʼKeefe, M., Murphy, J., Dolan, L. M., Traub, A. I., Slattery, M. M., Curley, A. E., Halliday, H. L., Tubman, T. R. J., Kileen, O., Riadha, H., Russell, J., Philips, R., Regan, C., Ali, I., Coughlan, A. C. J., Turner, M. J., Smith, A., OʼFlanagan, D., Igoe, D., Ryan, F., Forde, D., McArdle, E., Ko, D., Bedford, D., Hegarty, M., Dunlevy, B., Corcoran, R., Holohan, T., Feeney, A., McGee, H., Shannon, W., Condon, M., Hyland, C., Sayers, G., Feely, E., Crowley, D., OʼReilly, D., OʼConnell, T., Cronin, M., Johnson, H., Fitzgeraldi, M., Cafferkey, M., Breslin, A., Bonner, C. J., Foley, B., Fitzgerald, M., Wall, P. G., McNamara, E., Costigan, P., Prendergast, T., Foye, K., Cosgrove, C., Keane, A., Murphy, E., OʼDonnell, J., Quinlan, A., Thornton, L., Roch, E. A., Lyons, R. A., Maddocks, A., Barnes, P., Price, L., McCabe, M., Nash, P., Midha, A., Doyle, Y., Kilgallen, A., Wright, P., Ryan, T., De La Harpe, D., Harkins, V., Brennan, C., OʼConnell, V., Evans, D. S., Mhuircheartaigh, Ni J., OʼDonnell, J. M., Rhatigan, A., Shelley, E., Collins, C., Byrne, M., Murphy, A. W., Plunkett, P. K., Murray, A., Bury, G., Lynam, F., McMahon, G., Greally, T., Kane, D., Veale, D., Reece, R., Busteed, S., Bennett, M. W., Stone, M., Molloy, C., OʼConnell, J., Molloy, M. G., Shanahan, F., Guerin, J., Casey, E., Feighery, C., Lin, F., Jackson, J., Pendleton, A., Wright, G. D., Hughes, A. E., OʼGradaigh, D., Debham, I., Compston, J., McEvoy, A., Murphy, E. P., Salonen, D., Payne, P., Lax, M., Lapp, V., Inman, R., OʼRourke, K., Brennan, D., Harty, J., McCarthy, C., OʼByrne, J., Eustace, S., Chirayath, H., Liggett, N. W., Morgan, M. P., Fitzgerald, D. J., McCarthy, C. J., McCarthy, G. M., Lee, R. Z., Wai, K., Nevin, D., Leary, A. O., Lee, R., Casey, E. B., OʼLeary, A., Breen, D., Tuite, D., McInerney, D., Sim, R., Frederic, A. L., Smith, O., White, B., Murphy, M., Silke, C., OʼKeeffe, E., Fanning, N., Spence, L., Parfrey, N. A., McConnell, J. R., Crockard, A. D., Cairns, A. P., Bell, A. L., Kavanagh, O., Moyes, D. A., Finch, M., Rooney, M., Bell, A., Founas, I., El-Magbri, A., Mooney, S., Kennedy, M., Coughlan, R. J., Ramakrishnan, S. A., Gsel, A., Finnerty, O., Burns, M., Yateman, M., Camaco-Hubner, C., Matthews, C. F., Taggart, A., Fuller, K., Murphy, M. S., Phelan, M., Murphy, T. B., Wynne, F., Quane, K., Daly, M., OʼLeary, J., da Silva, I., Bermingham, N., Gogarty, M., Gallagher, L. P., OʼHara, R., Godson, C., Brady, H., Osman, H., El-Rafie, A., Foley-Nolan, D., Kirwan, P., Corcoran, O., Duffy, T., Drummond, F., Madigan, A., Williams, D., Gallagher, P., Hatton, C., Cunningham, S., FitzGerald, O., Minnock, P., Wylie, E., Egan, D., Mc Cormack, J., Shea, M. O., Evans, D., OʼLorcain, P., Comber, H., Evans, A., Jones, J., Garavan, C., Kelleher, K., Boland, M. C., Healy, R., OʼSullivan, M. B., Burke, M., Mc Donald, P., Smithson, R., Glass, J., Mason, C. A., Mullins, N., Nolan, D., McCormick, P., Coughlan, S., Dooley, S., Kelleher, C. C., Hope, A., Murphy, F., Barry, M., Sixsmith, J., MacFarlane, A., MacLeod, C., McElroy, G., OʼLoan, D., Kennedy, F., Kerr, R. M., Lim, J., Allwright, S. P. A., Bradley, F. L., Barry, J. M. G., Long, J., Parry, J. V., Creagh, D., Perry, I. J., Collins, A., Neilson, S., Colwell, N., OʼHalloran, D., OʼNeill, S., McErlain, S., Okasha, M., Gaffney, B., McCarron, P., Hinchion, R., Drew, C., Gavin, A., Fitzpatrick, D., Campbell, R., Wannamethee, S. G., Shaper, A., Friel, S., Kelleher, C., Kee, F., Atterson, C. C., Wilson, E. A., McConnell, J. M., Wheeler, S. M., Watson, J. D., Rahman, Norashikin N., Sheehan, J., Wall, C., Kelleher, B., OʼBroin, S. D., Mullan, R. N., McKeveney, P. J., Hodges, V. M., Winter, P. C., Maxwell, P., Simpson, D. A., Lappin, T. R. J., Maxwell, A. P., Eustace, J. A., Coresh, J., Kutchey, C., Te, P. L., Gimenez, L. F., Scheel, P. J., Walser, M., McMahon, R. A., Clarkson, M., Martin, F., Brady, H. R., Blake, C., OʼMeara, Y. M., Gupta, S., MacKenzie, H., Doyle, S., Fotheringham, T., Haslam, P., Logan, M. P., Conlon, P., Lee, M., Maderna, P., Cottell, D. C., Mitchell, S., Gulmann, C., Østerby, R., Bangstad, H. J., Rljdberg, S., Dempsey, M., Nathwani, S., Ryan, M. P., McMahon, B., Stenson, C., Murtagh, H., Brown, J. H., Doran, P., McGinty, A., Little, M. A., OʼBrien, E., Owens, P., Holian, J., Mee, F., Walshe, J. J., Omer, S. A., Power, D., Diamond, P., Watson, R. W., Shahsafei, A., Jiang, T., Brenner, B. M., Mackenzie, H. S., Neary, J., Dorman, A., Keoghan, M., Campbell, E., Walshe, J., Little, M., Nee, L., OʼCeallaigh, C., McGlynn, H., Bergin, E., Keane, T., Gormley, G., Watson, A., Atta, M. G., Perl, T. M., Song, X., Healy, E., Leonard, M., Lynch, J., Watson, A. J., Lappin, D., Lappin, D. W. P., Hannan, K., Burne, M., Daniels, F., Rabb, H., McBride, B., Kieran, N., Shortt, C., Codd, M., Murray, F., McCormack, A., Brown, C., Wong, C., Dorman, A. M., Keogan, M., Donohue, J., Farrell, J., Donohoe, J., OʼBroin, S., Balfe, A., Mellotte, G. J., Abraham, K. A., McGorrian, C., Wood, A. E., Neligan, M., Kelly, B. D., Finnegan, P., Cormican, M., Callaghan, J., Crean, J. K. G., Moffitt, T. A., Devlin, H. L., Garrett, P. J., Soosay, A., OʼNeill, D., Counihan, A., Hickey, D., Keogan, M. T., Harvey, K., OʼRiordan, E., Waldek, S., Kalra, P. A., OʼDonoghue, D. J., Foley, R. N., Kelliher, D., Mellotte, G., Giblin, L., Keogh, J. A. B., OʼConnell, M., OʼMeara, A., Breatnach, F., Gillick, J., Tazawa, H., Puri, P., Molloy, E., OʼNeill, A. J., Sheridan-Pereira, M., Fitzpatrick, J. M., Webb, D. W., Watson, R. W. G., Linnane, B., OʼDonnell, C., Clarke, T. A., Martin, C., McKay, M., McBrien, J., Glynn, F., OʼDonovan, C., Hall, W. W., Smith, J., Khair, K., Liesner, R., Hann, I. M., Smith, O. P., Gallagher, S., Mahony, M. J., Hilal, A., Cosgrove, J. F., Monaghan, C., Craig, B., Walsh, K., Duff, D., Slizlok, P. O., Halahakoon, C., McMillan, S., Dalzell, E. E., McCaughan, J., Redmond, A. O. B., DeCaluwe, D., Yoneda, A., Akl, U., Dempsey, E., Farrell, M., Webb, D., Elabbas, A., Fox, G., Gormally, S., Grant, B., Corkey, C. W. B., Nicholson, A., Murphy, A., OʼGrady, P., Barry, O., Stewart, M. C., Alderdice, F., Matthews, T. G., McDonnell, M., McGarvey, C., OʼRegan, M., Chróinín, Ní M., Tormey, P., Ennis, S., Green, A. J., Abbas, S., OʼMarcaigh, A., Conran, M., Crushell, E., Saidi, A., Curran, P., Donoghue, V., King, M. D., Elnazir, B., Leonard, J., Kavanagh, C., Brown, D., Corrigan, N., McCord, B., Quinn, M., OʼConnell, L., Mcdonagh, B., Awan, A., Gill, D., Kakkar, R., Warner, J. A., OʼConnor, C., Herzig, M., Twomey, A., White, M. J., Sweeney, B., Surana, R., Hodgson, A., Rafferty, M., Livingstone, W., Peake, D., Wassemer, E., Whitehouse, W., Abdullah, N., Al-Hassan, A., Oslizlok, P., OʼConnell, N., Balding, J., Livingstone, W. J., Healy, M., Mynett-Johnson, L., McAllister, I., Dick, A. C., Herron, B., Boston, V. E., Callaghan, C. O., Brien, D. O., Walsh, A., Philip, M., McShane, D., Hoey, M. C. V., Sharif, F., McDermott, M., Dillon, M., Drumm, B., Rowland, M., Imrie, C., Kelleher, S., Bourke, B., Iqbal, M., Ziedan, Y., OʼNeill, M., OʼRiordan, S., Basheer, S. M. B., OʼCallaghan, S., Chong, A., Kelly, M., Nicholson, A. J., Cooke, R., Sreenan, C., Fallon, M., Denham, B., Dowding, V., Cussen, G., McManus, V., Hensey, O., Monaghan, H., Basheer, S. N., Quinn, E., Hoey, H. M. C. V., Mohamed, S., Ramesh, R. R., Mayne, P., Tracy, E., Gormally, S. M., Curtis, E., McCallion, N., Watson, R., OʼMahony, O., Keegan, M., Ward, K., Barton, D., Poulton, J., Treacy, E., Honour, J., deCaluwe, D., Chróinín, Ni M., Cosgrove, J., Chaudhry, T. S., Long, N. M., Lynch, B., Lasjaunais, P., McDonald, D. G. M., McMenamin, J. B., Farrell, M. J., Roche, E. F., Menon, A., Buckley, C., Mackey, A., Ohlandieck, K., Das, A., Reilly, D., Killeen, O., Harper, J., Roche, E., Hoey, H., Caird, J., OʼBrien, D., Allcutt, D., Farrington, N., Murphy, J. F. A., Savage, J. M., Sands, A. J., Casey, F. A., Craig, B. G., Dornan, J. C., Johnston, J., Patterson, C., Lynch, C., Mulholland, H. C., Watkins, D. C., Young, I., Cran, G., Boreham, C. A. G., McCallion, W. A., Clements, N. F., Stevenson, M. R., Macpherson, C., Jenkins, L., Thompson, A. J., Shields, M. D., Taylor, R. T., Kerr, R., Hughes, J. L., Stewart, M., Jackson, P., Fitzpatrick, C., Rasheed, M., Colhoun, E., Bailie, A. G., Gray, S., Brown, S., Curley, A., Sweet, D. G., MacMahon, K. J., OʼConnor, C. M., Nichelson, A., Lynch, N. E., Finch, D., Foley, M., Scallan, E., Dillon, B., Lyons, S., OʼLoughlin, R., Ward, M., Nally, R., Harkin, A., Kelly, J. P., Leonard, B. E., Magee, P., Connor, T. J., Shen, Y., McCullough, G. R., McDonough, S. M., Niocaill, Nic B., Cramp, A. F. L., Hynes, M., Corkery, P., Carey, M., McGarrigle, D., Higgins, S., Murray, H., Moran, C. J., Dennedy, M. C., Brosnan, J., Morris, L., Sheppard, B. L., Black, A., Wilkins, B., Folan-Curran, J., Skelton, K., Owens, M., Nemeroff, C., Houlihan, D., OʼKeeffe, C., Nolan, N., McCormick, P. A., Baird, A. W., Raducan, I., Corcoran, P., Brennan, R., Molloy, P., Friel, A., Maher, M., Glennon, M., Smith, T., Nolan, A., Houghton, J. A., Carroll, O., Colleran, S., OʼCuinn, G., Snow, H. M., OʼRegan, D., Markos, H. F., Pollock, K., Cannon, D. M., McBean, G., OʼRiordan, A., Quinlan, L. R., Kane, M. T., Higglns, B. D., Moriarty, D. M., Fitzgerald, D., Katkada, A., Canny, G., MacMathuna, P., OʼDonoghue, D., OʼDonovan, M. M., Schuur, A. G., Murphy, K. J., Foley, A. G., ten Bruggencate, S. J. M., and Ireland, L.

Published
2000
Full Text
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27. Royal Academy of Medicine in Ireland Section of Pathology: Proceedings of meeting held 24th January, 1996

Author

Harbourne, G., Byrne, P. C., Webb, S., Hutchinson, M., Parfrey, N. A., McMenamin, M., O’Neill, A., Gaffney, E., Callagy, G., Crowe, J., O’Keane, J. C., Murphy, J., Waters, E., Madden, M., Shanahan, F., O’Sullivan, G., Lee, G., Brennan, F. K., Connolly, C. E., Cunney, R. J., McNamara, E. B., Alansari, N., Loo, B., Smyth, E. G., Duggan, C., O’Brien, D., McCann, S. R., Lynch, M., Cotter, L., Cryan, B., Greer, P., and Fanning, S.

Published
1997
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30. A technique comparison: VMAT versus Step and Shoot IMRT for intact prostate radiotherapy

Author

Hamilton, D, Keats, S, Juresic, E, Rai, R, Brazel, A, Martel, M, Cokelek, M, McGettigan, R, Harris, N, Price, S, Wright, J, Neilson, K, Richdale, K, Mudie, B, Montgomerie, D, Tran, P, Barnes, T, McNamara, E, Wilson, L, Pearce, B, Phillips, E, Lengren, J, Shephard, G, Bleasard, M, Leotta, V, Cross, A, Khuat, R, Sim, J, Yielder, J, Wearn, A, Izman, M, Tanner, L, Aditama, E, Dalrymple, L, Jones, K, Benny, K, Hayes, J, Trenberth, E, and Keyse, S

Subjects
ePosters – Radiation Therapy, ePosters – Medical Imaging, Abstracts From the 2015 Nzimrt-Air Scientific Meeting “the Cloud: Shaping Our Future” Wellington, New Zealand 24–26 July 2015
Published
2015

32. Reversal of end-stage heart failure in juvenile hemochromatosis with iron chelation therapy: a case report.

Author

Cooray, SD, Heerasing, NM, Selkrig, LA, Subramaniam, VN, Hamblin, PS, McDonald, CJ, McLean, CA, McNamara, E, Leet, AS, Roberts, SK, Cooray, SD, Heerasing, NM, Selkrig, LA, Subramaniam, VN, Hamblin, PS, McDonald, CJ, McLean, CA, McNamara, E, Leet, AS, and Roberts, SK

Abstract

BACKGROUND: Juvenile hemochromatosis is the most severe form of iron overloading phenotype. Although rare, it should be suspected in patients who present with hypogonadotropic hypogonadism, diabetes mellitus, or cardiomyopathy without a clear cause. CASE PRESENTATION: A young Serbian male presenting with end-stage heart failure was referred for extracorporeal membrane oxygenation. An endomyocardial biopsy revealed cytoplasmic iron deposits in myocytes. His condition was stabilized with biventricular assist devices and he was listed for heart transplantation. Iron chelation therapy was commenced and resulted in rapid removal of iron burden. Serial outpatient echocardiograms demonstrated myocardial recovery such that a successful biventricular assist device explant occurred 131 days after initial implant. Targeted gene sequencing revealed a loss-of-function mutation within the HJV gene, which is consistent with juvenile hemochromatosis. CONCLUSIONS: This rare case of a patient with juvenile hemochromatosis associated with a HJV mutation provides histologic evidence documenting the reversal of associated end-stage heart failure, requiring emergent mechanical circulatory support, with iron chelation therapy.

Published
2018

34. All in the Principal's Schedule

Author

McNamara, E. T.

Abstract

Lists the important and the trivial tasks included in a principal's schedule. (IRT)

Published
1977

35. CONGENITAL MYOPATHIES: NEMALINE AND TITINOPATHIES

Author

Laitila, J., primary, McNamara, E., additional, Goullee, H., additional, Wingate, C., additional, Lawlor, M., additional, Ross, J., additional, Ochala, J., additional, Griffiths, L., additional, Ravenscroft, G., additional, Sewry, C., additional, Laing, N., additional, Wallgren-Pettersson, C., additional, Pelin, K., additional, and Nowak, K., additional

Published
2018
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36. Startup thaw concept for the SP-100 space reactor power system

Author

Kirpich, A, Das, A, Choe, H, Mcnamara, E, Switick, D, and Bhandari, P

Subjects
Spacecraft Propulsion And Power
Abstract

A thaw concept for a space reactor power system which employs lithium as a circulant for both the heat-transport and the heat-rejection fluid loops is presented. An exemplary thermal analysis for a 100-kWe (i.e., SP-100) system is performed. It is shown that the design of the thaw system requires a thorough knowledge of the various physical states of the circulant throughout the system, both spatially and temporally, and that the design has to provide adequate margins for the system to avoid a structural or thermally induced damage.

Published
1990

37. Gene Expression Networks in the Murine Pulmonary Myocardium Provide Insight into the Pathobiology of Atrial Fibrillation.

Author

Boutilier, JK, Taylor, RL, Mann, T, McNamara, E, Hoffman, GJ, Kenny, J, Dilley, RJ, Henry, P, Morahan, G, Laing, NG, Nowak, KJ, Boutilier, JK, Taylor, RL, Mann, T, McNamara, E, Hoffman, GJ, Kenny, J, Dilley, RJ, Henry, P, Morahan, G, Laing, NG, and Nowak, KJ

Abstract

The pulmonary myocardium is a muscular coat surrounding the pulmonary and caval veins. Although its definitive physiological function is unknown, it may have a pathological role as the source of ectopic beats initiating atrial fibrillation. How the pulmonary myocardium gains pacemaker function is not clearly defined, although recent evidence indicates that changed transcriptional gene expression networks are at fault. The gene expression profile of this distinct cell type in situ was examined to investigate underlying molecular events that might contribute to atrial fibrillation. Via systems genetics, a whole-lung transcriptome data set from the BXD recombinant inbred mouse resource was analyzed, uncovering a pulmonary cardiomyocyte gene network of 24 transcripts, coordinately regulated by chromosome 1 and 2 loci. Promoter enrichment analysis and interrogation of publicly available ChIP-seq data suggested that transcription of this gene network may be regulated by the concerted activity of NKX2-5, serum response factor, myocyte enhancer factor 2, and also, at a post-transcriptional level, by RNA binding protein motif 20. Gene ontology terms indicate that this gene network overlaps with molecular markers of the stressed heart. Therefore, we propose that perturbed regulation of this gene network might lead to altered calcium handling, myocyte growth, and contractile force contributing to the aberrant electrophysiological properties observed in atrial fibrillation. We reveal novel molecular interactions and pathways representing possible therapeutic targets for atrial fibrillation. In addition, we highlight the utility of recombinant inbred mouse resources in detecting and characterizing gene expression networks of relatively small populations of cells that have a pathological significance.

Published
2017

40. TPM3 Deletions Cause a Hypercontractile Congenital Muscle Stiffness Phenotype

Author

Donkervoort, S., Papadaki, M., de Winter, JM., Neu, MB., Kirschner, J., Bolduc, V., Yang, ML., Gibbons, MA., Hu, Y., Dastgir, J., Leach, ME., Rutkowski, A., Foley, AR., Krüger, M., Wartchow, EP., McNamara, E., Ong, R., Nowak, KJ., Laing, NG., Clarke, NF., Ottenheijm, CAC., Marston, SB., Bönnemann, CG., Physiology, ICaR - Heartfailure and pulmonary arterial hypertension, and British Heart Foundation

Subjects
Male, Neurology & Neurosurgery, Muscle Fibers, Skeletal, 1103 Clinical Sciences, Tropomyosin, Article, Phenotype, Muscular Diseases, Child, Preschool, Mutation, Humans, Exome, Female, Respiratory Insufficiency, 1109 Neurosciences, Muscle Contraction, Sequence Deletion
Abstract

Mutations in TPM3, encoding Tpm3.12, cause a clinically and histopathologically diverse group of myopathies characterized by muscle weakness. We report two patients with novel de novo Tpm3.12 single glutamic acid deletions at positions ΔE218 and ΔE224, resulting in a significant hypercontractile phenotype with congenital muscle stiffness, rather than weakness, and respiratory failure in one patient.The effect of the Tpm3.12 deletions on the contractile properties in dissected patient myofibers was measured. We used quantitative in vitro motility assay to measure Ca(2+) sensitivity of thin filaments reconstituted with recombinant Tpm3.12 ΔE218 and ΔE224.Contractility studies on permeabilized myofibers demonstrated reduced maximal active tension from both patients with increased Ca(2+) sensitivity and altered cross-bridge cycling kinetics in ΔE224 fibers. In vitro motility studies showed a two-fold increase in Ca(2+) sensitivity of the fraction of filaments motile and the filament sliding velocity concentrations for both mutations.These data indicate that Tpm3.12 deletions ΔE218 and ΔE224 result in increased Ca(2+) sensitivity of the troponin-tropomyosin complex, resulting in abnormally active interaction of the actin and myosin complex. Both mutations are located in the charged motifs of the actin-binding residues of tropomyosin 3, thus disrupting the electrostatic interactions that facilitate accurate tropomyosin binding with actin necessary to prevent the on-state. The mutations destabilize the off-state and result in excessively sensitized excitation-contraction coupling of the contractile apparatus. This work expands the phenotypic spectrum of TPM3-related disease and provides insights into the pathophysiological mechanisms of the actin-tropomyosin complex.

Published
2015

41. Event-based surveillance of food- and waterborne diseases in Europe: ‘urgent inquiries’ (outbreak alerts) during 2008 to 2013

Author

Gossner, Céline Marie Elise, De Jong, B, Hoebe, CJ, Coulombier, D, Kornschober, C, Schmid, D, Quoilin, S, Koliou, M, Kralova, R, Marejkova, M, Ethelberg, S, Muller, L, Torpdahl, M, Nielsen, E Møller, Epstein, J, Dontsenko, I, Lienemann, T, Rimhanen-Finne, R, Kuusi, M, Siitonen, A, Silva, N Jourdan-Da, King, L, Le Hello, S, Leclercq, A, Bernard, H, Frank, C, Werber, D, Rabsch, W, Mellou, K, Krisztalovics, K, Paszti, J, Sigmundsdottir, G, Hardardottir, H, Garvey, P, McKeown, P, Cormican, M, McNamara, E, Scavia, G, Luzzi, I, Korotinska, R, Zagrebneviene, G, Gatt, A, Nygård, Karin Maria, Vold, Line, Brandal, Lin Thorstensen, Wester, Astrid Lousie, Dufour, M, Zota, L, Mikas, J, Grilc, E, Martinez, C Varela, Leon, S Herrera, Keddy, KH, Ivarsson, S, Löfdahl, M, Jernberg, C, Hedenström, I, Friesema, I, Verhoef, L, Van Pelt, W, Heck, M, Lane, C, Peters, T, Awofisayo, A, Brownlie, S, and Gerner-Smidt, P

Published
2015

45. COMMON SENSE: Cost-effective sensors, interoperable with international existing ocean observing systems, to meet EU policies requirements

Author

Cleary J., McCaul M., Diamond D., Garcia M.B.G., Diez C., Rovira C., Challiss M., Lassoued Y., Ribotti A., Saez J., Barton J., Salat J., Magni P., Antognarelli F., Borghini M., Schroeder K., Fanjul P., Hernandez D., Ni Cheallachain C., Gamboa J.V., Piwowarczyk J., Pizarro C., Moynihan E., Grozdanov A., Confalonieri F., Heckmann S., and McNamara E.

Subjects
Underwater noise, Engineering, Focus (computing), Sensor networks, business.industry, media_common.quotation_subject, Sensor development, Interoperability, Common sense, Heavy metals, Marine monitoring, computer.software_genre, Sensor web, Software, Systems engineering, Key (cryptography), Data integration, Data mining, business, computer, media_common
Abstract

The COMMON SENSE (CS) project aims to develop cost-effective, multi-functional innovative sensors to perform reliable in-situ measurements in the marine environment. The COMMON SENSE sensors will focus on key parameters including eutrophication, heavy metals, marine litter (microplastics) and underwater noise. The project will focus on increasing the availability of sensor data and observations through the development and implementation of the Common Sensor Web Platform (CSWP), a software platform that will integrate the COMMON SENSE sensor data and observations and deliver them to the Web, in standard formats and through standard interfaces.

Published
2014

47. Landfill gas monitoring network - development of wireless sensor network platforms

Author

Collins, F., Orpen, D., Mcnamara, E., Cormac Fay, and Diamond, D.

Subjects
Environmental chemistry, Telecommunication, Environmental engineering
Abstract

A wireless sensor network has been developed for the application of landfill gas monitoring, specifically sensing methane, carbon dioxide and extraction pressure. This collaborative work with the Irish Environmental Protection Agency has been motivated by the need to reduce greenhouse gas emissions as well as aiming to improve landfill gas management and utilisation. This paper describes the preliminary findings of an ongoing trial deployment of multiple sensing platforms on an active landfill facility; data has been acquired for nine months to date. The platforms have operated successfully despite adverse on-site conditions, with validity demonstrated by reasonably strong correlation with independent on-site measurements. The increased temporal and spatial resolution provided by distributed sensor platforms is discussed with regard to improving landfill gas management practice.

Published
2013

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