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3. Geometry in the Secondary School, A Compendium of Papers Presented in Houston, Texas, January 29, 1967, at a Joint Session of The Mathematical Association of America and The National Council of Teachers of Mathematics.

Author

National Council of Teachers of Mathematics, Inc., Reston, VA. and McNabb, W. K.

Abstract

This booklet is a collection of the papers presented at a joint session of the Mathematical Association of America and the National Council of Teachers of Mathematics during the fiftieth annual meeting of the MAA. These papers were presented under the headings of "Geometry and School Mathematics,""High School Geometry," and "School Geometry and the Future." Eight papers are presented in their entirety. An abstract of a ninth paper, "Geometry: The Cambridge Conference View" by Edwin E. Moise is also included. Authors of the individual papers do not act as spokesmen for the MAA or NCTM but express personal viewpoints. (FL)

Published
1967

19. Live Faecalibacterium prausnitzii in an apical anaerobic model of the intestinal epithelial barrier

Author

Ulluwishewa, Dulantha, Anderson, R., Young, W., Mcnabb, W., van Baarlen, P., Moughan, P., Wells, J., Roy, N., Ulluwishewa, Dulantha, Anderson, R., Young, W., Mcnabb, W., van Baarlen, P., Moughan, P., Wells, J., and Roy, N.

Abstract

© 2014 John Wiley & Sons Ltd. Faecalibacterium prausnitzii, an abundant member of the human commensal microbiota, has been proposed to have a protective role in the intestine. However, it is an obligate anaerobe, difficult to co-culture in viable form with oxygen-requiring intestinal cells. To overcome this limitation, a unique apical anaerobic model of the intestinal barrier, which enabled co-culture of live obligate anaerobes with the human intestinal cell line Caco-2, was developed. Caco-2 cells remained viable and maintained an intact barrier for at least 12h, consistent with gene expression data, which suggested Caco-2 cells had adapted to survive in an oxygen-reduced atmosphere. Live F.prausnitzii cells, but not ultraviolet (UV)-killed F.prausnitzii, increased the permeability of mannitol across the epithelial barrier. Gene expression analysis showed inflammatory mediators to be expressed at lower amounts in Caco-2 cells exposed to live F.prausnitzii than UV-killed F.prausnitzii, This, consistent with previous reports, implies that live F.prausnitzii produces an anti-inflammatory compound in the culture supernatant, demonstrating the value of a physiologically relevant co-culture system that allows obligate anaerobic bacteria to remain viable.

Published
2015

20. Edelmetalle

Author

Bloom, A., McNabb, W. M., Wogrinz, A., Haslewood, G. A. D., Strishewski, I. I., Clark, R. E. D., Zappi, E. V., Manini, Alice, Douglas, G. V., Gillis, N. B., Posharitzki, K., Schtschekin, W., Marenkow, J. A., Blinder, I. I., Freidman, S. M., Costeanu, N. D., Bihlmaier, K., Mankin, W., Forbes, E. C., Beamish, F. E., Thompson, S. O., Scott, M., Grünberg, A. A., and Pticyn, B. V.

Published
1939
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21. Edelmetalle

Author

Hegemann, Fr., Rost, Fr., Raeder, M. G., Kyllingstad, O. S., Fuchs, K., Szebellédy, L., Viczián, B., Weisberg, L., Kushner, J. B., Deischer, C. K., McNabb, W. M., Beamish, F. E., Scott, M., and Russell, J. J.

Published
1941
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22. Mammary transcriptome analysis of lactating dairy cows following administration of bovine growth hormone.

Author

McCoard, S. A., Hayashi, A. A., Sciascia, Q., Rounce, J., Sinclair, B., McNabb, W. C., and Roy, N. C.

Abstract

The galactopoietic effect of growth hormone (GH) in lactating ruminants is well established; however the mechanisms that mediate these effects are not well understood. The first objective of this study was to determine the effect of GH on the synthesis of the major casein and whey proteins. The second objective was to identify the genes and pathways that may be involved in mediating the effect of GH on milk synthesis. A single subcutaneous injection of a commercially available slow release formulation of GH (Lactatropin®), or physiological saline solution (control) was administered to non-pregnant dairy cows (n=4/group) in mid-late lactation. Milk samples were collected for composition analysis and mammary lobulo-alveolar tissue was collected postmortem 6 days post injection. Gene expression profiles were evaluated using either a 22 000 bovine complementary DNA microarray or quantitative PCR (qPCR), and microarrays were validated by qPCR. The yield of all the major casein and whey proteins was increased 32% to 41% in GH-treated cows, with the exception of α-lactalbumin yield which was elevated by 70% relative to controls. Treatment with GH treatment tended to increase the concentration of α-lactalbumin but had no effect on the concentration of any of the major milk proteins. Messenger RNA (mRNA) abundance of the major whey and casein genes, with the exception of α-s2-casein, was increased in response to GH compared with controls, which is consistent with the positive effect of GH on milk production. Treatment with GH treatment influenced the mRNA abundance of genes involved in cell growth and proliferation, transcriptional and translational regulation, actin cytoskeleton signalling, lipid metabolism and cell death. This study has provided new insights into the cell signalling that may be involved in mediating the effect of GH on milk production in the mammary gland of lactating dairy cows. [ABSTRACT FROM PUBLISHER]

Published
2016
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24. Regulation of tight junction permeability by intestinal bacteria and dietary components

Author

Ulluwishewa, Dulantha, Anderson, R., McNabb, W., Moughan, P., Wells, J., Roy, N., Ulluwishewa, Dulantha, Anderson, R., McNabb, W., Moughan, P., Wells, J., and Roy, N.

Abstract

The human intestinal epithelium is formed by a single layer of epithelial cells that separates the intestinal lumen from the underlying lamina propria. The space between these cells is sealed by tight junctions (TJ), which regulate the permeability of the intestinal barrier. TJ are complex protein structures comprised of transmembrane proteins, which interact with the actin cytoskeleton via plaque proteins. Signaling pathways involved in the assembly, disassembly, and maintenance of TJ are controlled by a number of signaling molecules, such as protein kinase C, mitogen-activated protein kinases, myosin light chain kinase, and Rho GTPases. The intestinal barrier is a complex environment exposed to many dietary components and many commensal bacteria. Studies have shown that the intestinal bacteria target various intracellular pathways, change the expression and distribution of TJ proteins, and thereby regulate intestinal barrier function. The presence of some commensal and probiotic strains leads to an increase in TJ proteins at the cell boundaries and in some cases prevents or reverses the adverse effects of pathogens. Various dietary components are also known to regulate epithelial permeability by modifying expression and localization of TJ proteins. © 2011 American Society for Nutrition.

Published
2011

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