Search

Your search keyword '"McMillan, Nigel A.J."' showing total 131 results
Start Over Author "McMillan, Nigel A.J."
131 results on '"McMillan, Nigel A.J."'

8. Immune responses in children after vaccination with a typhoid Vi-tetanus toxoid conjugate vaccine in Bangladesh

Author

Khanam, Farhana, primary, Babu, Golap, additional, Rahman, Nazia, additional, Liu, Xinxue, additional, Rajib, Nazmul Hasan, additional, Ahmed, Shams Uddin, additional, Hossen, Md Ismail, additional, Biswas, Prasanta Kumar, additional, Kelly, Sarah, additional, Thesis-Nyland, Katherine, additional, Mujadidi, Yama, additional, McMillan, Nigel A.J., additional, Pollard, Andrew J, additional, Clemens, John D, additional, and Qadri, Firdausi, additional

Published
2023
Full Text
View/download PDF

10. Data from Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer

Author

Gabrielli, Brian, primary, Bokhari, Fawzi, primary, Ranall, Max V., primary, Oo, Zay Yar, primary, Stevenson, Alexander J., primary, Wang, Weili, primary, Murrell, Melanie, primary, Shaikh, Mushfiq, primary, Fallaha, Sora, primary, Clarke, Daniel, primary, Kelly, Madison, primary, Sedelies, Karin, primary, Christensen, Melinda, primary, McKee, Sara, primary, Leggatt, Graham, primary, Leo, Paul, primary, Skalamera, Dubravka, primary, Soyer, H. Peter, primary, Gonda, Thomas J., primary, and McMillan, Nigel A.J., primary

Published
2023
Full Text
View/download PDF

11. Supplementary Tables S2, S3 from Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer

Author

Gabrielli, Brian, primary, Bokhari, Fawzi, primary, Ranall, Max V., primary, Oo, Zay Yar, primary, Stevenson, Alexander J., primary, Wang, Weili, primary, Murrell, Melanie, primary, Shaikh, Mushfiq, primary, Fallaha, Sora, primary, Clarke, Daniel, primary, Kelly, Madison, primary, Sedelies, Karin, primary, Christensen, Melinda, primary, McKee, Sara, primary, Leggatt, Graham, primary, Leo, Paul, primary, Skalamera, Dubravka, primary, Soyer, H. Peter, primary, Gonda, Thomas J., primary, and McMillan, Nigel A.J., primary

Published
2023
Full Text
View/download PDF

12. Supplementary Methods and Supplementary Figures S1-S13 from Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer

Author

Gabrielli, Brian, primary, Bokhari, Fawzi, primary, Ranall, Max V., primary, Oo, Zay Yar, primary, Stevenson, Alexander J., primary, Wang, Weili, primary, Murrell, Melanie, primary, Shaikh, Mushfiq, primary, Fallaha, Sora, primary, Clarke, Daniel, primary, Kelly, Madison, primary, Sedelies, Karin, primary, Christensen, Melinda, primary, McKee, Sara, primary, Leggatt, Graham, primary, Leo, Paul, primary, Skalamera, Dubravka, primary, Soyer, H. Peter, primary, Gonda, Thomas J., primary, and McMillan, Nigel A.J., primary

Published
2023
Full Text
View/download PDF

13. Supplementary Table S1 from Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer

Author

Gabrielli, Brian, primary, Bokhari, Fawzi, primary, Ranall, Max V., primary, Oo, Zay Yar, primary, Stevenson, Alexander J., primary, Wang, Weili, primary, Murrell, Melanie, primary, Shaikh, Mushfiq, primary, Fallaha, Sora, primary, Clarke, Daniel, primary, Kelly, Madison, primary, Sedelies, Karin, primary, Christensen, Melinda, primary, McKee, Sara, primary, Leggatt, Graham, primary, Leo, Paul, primary, Skalamera, Dubravka, primary, Soyer, H. Peter, primary, Gonda, Thomas J., primary, and McMillan, Nigel A.J., primary

Published
2023
Full Text
View/download PDF

14. Supplementary Figures 1 - 5 from MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells

Author

Plummer, Prue N., primary, Freeman, Ruth, primary, Taft, Ryan J., primary, Vider, Jelena, primary, Sax, Michael, primary, Umer, Brittany A., primary, Gao, Dingcheng, primary, Johns, Christopher, primary, Mattick, John S., primary, Wilton, Stephen D., primary, Ferro, Vito, primary, McMillan, Nigel A.J., primary, Swarbrick, Alexander, primary, Mittal, Vivek, primary, and Mellick, Albert S., primary

Published
2023
Full Text
View/download PDF

15. Supplementary Methods and Figure Legend from MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells

Author

Plummer, Prue N., primary, Freeman, Ruth, primary, Taft, Ryan J., primary, Vider, Jelena, primary, Sax, Michael, primary, Umer, Brittany A., primary, Gao, Dingcheng, primary, Johns, Christopher, primary, Mattick, John S., primary, Wilton, Stephen D., primary, Ferro, Vito, primary, McMillan, Nigel A.J., primary, Swarbrick, Alexander, primary, Mittal, Vivek, primary, and Mellick, Albert S., primary

Published
2023
Full Text
View/download PDF

16. Data from MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells

Author

Plummer, Prue N., primary, Freeman, Ruth, primary, Taft, Ryan J., primary, Vider, Jelena, primary, Sax, Michael, primary, Umer, Brittany A., primary, Gao, Dingcheng, primary, Johns, Christopher, primary, Mattick, John S., primary, Wilton, Stephen D., primary, Ferro, Vito, primary, McMillan, Nigel A.J., primary, Swarbrick, Alexander, primary, Mittal, Vivek, primary, and Mellick, Albert S., primary

Published
2023
Full Text
View/download PDF

17. Supplementary Figures 9 - 10 from MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells

Author

Plummer, Prue N., primary, Freeman, Ruth, primary, Taft, Ryan J., primary, Vider, Jelena, primary, Sax, Michael, primary, Umer, Brittany A., primary, Gao, Dingcheng, primary, Johns, Christopher, primary, Mattick, John S., primary, Wilton, Stephen D., primary, Ferro, Vito, primary, McMillan, Nigel A.J., primary, Swarbrick, Alexander, primary, Mittal, Vivek, primary, and Mellick, Albert S., primary

Published
2023
Full Text
View/download PDF

18. Supplementary Figure 11 from MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells

Author

Plummer, Prue N., primary, Freeman, Ruth, primary, Taft, Ryan J., primary, Vider, Jelena, primary, Sax, Michael, primary, Umer, Brittany A., primary, Gao, Dingcheng, primary, Johns, Christopher, primary, Mattick, John S., primary, Wilton, Stephen D., primary, Ferro, Vito, primary, McMillan, Nigel A.J., primary, Swarbrick, Alexander, primary, Mittal, Vivek, primary, and Mellick, Albert S., primary

Published
2023
Full Text
View/download PDF

19. Supplementary Figures 6 - 8 from MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells

Author

Plummer, Prue N., primary, Freeman, Ruth, primary, Taft, Ryan J., primary, Vider, Jelena, primary, Sax, Michael, primary, Umer, Brittany A., primary, Gao, Dingcheng, primary, Johns, Christopher, primary, Mattick, John S., primary, Wilton, Stephen D., primary, Ferro, Vito, primary, McMillan, Nigel A.J., primary, Swarbrick, Alexander, primary, Mittal, Vivek, primary, and Mellick, Albert S., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Tables 1 - 8 from MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells

Author

Plummer, Prue N., primary, Freeman, Ruth, primary, Taft, Ryan J., primary, Vider, Jelena, primary, Sax, Michael, primary, Umer, Brittany A., primary, Gao, Dingcheng, primary, Johns, Christopher, primary, Mattick, John S., primary, Wilton, Stephen D., primary, Ferro, Vito, primary, McMillan, Nigel A.J., primary, Swarbrick, Alexander, primary, Mittal, Vivek, primary, and Mellick, Albert S., primary

Published
2023
Full Text
View/download PDF

21. The interplay between WASH practices and vaccination with oral cholera vaccines in protecting against cholera in urban Bangladesh: Reanalysis of a cluster-randomized trial

Author

Chowdhury, Fahima, primary, Aziz, Asma Binte, additional, Ahmmed, Faisal, additional, Ahmed, Tasnuva, additional, Kang, Sophie SY, additional, Im, Justin, additional, Park, Juyeon, additional, Tadesse, Birkneh Tilahun, additional, Islam, Md. Taufiqul, additional, Kim, Deok Ryun, additional, Hoque, Masuma, additional, Pak, Gideok, additional, Khanam, Farhana, additional, McMillan, Nigel A.J., additional, Liu, Xinxue, additional, Zaman, Khalequ, additional, Khan, Ashraful Islam, additional, Kim, Jerome H., additional, Marks, Florian, additional, Qadri, Firdausi, additional, and Clemens, John D., additional

Published
2023
Full Text
View/download PDF

30. A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19

Author

Idris, Adi, primary, Davis, Alicia, additional, Supramaniam, Aroon, additional, Acharya, Dhruba, additional, Kelly, Gabrielle, additional, Tayyar, Yaman, additional, West, Nic, additional, Zhang, Ping, additional, McMillan, Christopher L.D., additional, Soemardy, Citradewi, additional, Ray, Roslyn, additional, O’Meally, Denis, additional, Scott, Tristan A., additional, McMillan, Nigel A.J., additional, and Morris, Kevin V., additional

Published
2021
Full Text
View/download PDF

31. Complete protection by a single dose skin patch delivered SARS-CoV-2 spike vaccine

Author

McMillan, Christopher L.D., primary, Choo, Jovin J.Y., additional, Idris, Adi, additional, Supramaniam, Aroon, additional, Modhiran, Naphak, additional, Amarilla, Alberto A., additional, Isaacs, Ariel, additional, Cheung, Stacey T.M., additional, Liang, Benjamin, additional, Bielefeldt-Ohmann, Helle, additional, Azuar, Armira, additional, Acharya, Dhruba, additional, Kelly, Gabrielle, additional, Fernando, Germain J.P., additional, Landsberg, Michael J., additional, Khromykh, Alexander A., additional, Watterson, Daniel, additional, Young, Paul R., additional, McMillan, Nigel A.J., additional, and Muller, David A., additional

Published
2021
Full Text
View/download PDF

32. Both treated and untreated tumors are eliminated by short hairpin RNA-based induction of target-specific immune responses

Author

Gu, Wenyi, Cochrane, Melanie, Leggatt, Graham R., Payne, Elizabeth, Choyce, Allison, Zhou, Fang, Tindle, Robert, and McMillan, Nigel A.J.

Subjects
Immune response -- Research, Tumors -- Care and treatment, Tumors -- Genetic aspects, RNA -- Health aspects, Cancer -- Care and treatment, Cancer -- Research, Cancer -- Genetic aspects, Science and technology
Abstract

RNA interference (RNAi) for cancer treatment relies on the ability to directly kill cancer cells via down-regulation of target genes, but issues of delivery and efficacy have limited clinical adoption. Furthermore, current studies using immune-deficient animal models disregard potential interactions with the adaptive immune system. It has previously been observed that certain viral antigens appear to be more rapidly presented to the immune system than normal proteins due to the production of defective ribosomal products by the virus. Given that RNAi could potentially result in the generation of truncated mRNAs, we wondered whether a similar mechanism of immune presentation of a target gene was possible. Here we show that RNAi-cleaved mRNAs can be translated into incomplete protein, and if cleavage was downstream of cytotoxic T cell epitopes, resulted in increased presentation of target protein and the generation of a tumor-protective immune response. We show that mice inoculated with tumor cells treated with such short hairpin RNAs (shRNAs) were protected from subsequent challenge with untreated tumors. However, protection was only found if shRNAs were targeted downstream of the dominant cytotoxic T cell (CTL) epitope. Our work suggests that RNAi can alter immunity to targets and shows that not all tumor cells require direct RNAi exposure for treatment to be effective in vivo, pointing the way to a new class of RNAi-based therapy. antigen presentation | cancer | CTL epitope | RNAi

Published
2009

43. Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer

Author

Gabrielli, Brian, primary, Bokhari, Fawzi, additional, Ranall, Max V., additional, Oo, Zay Yar, additional, Stevenson, Alexander J., additional, Wang, Weili, additional, Murrell, Melanie, additional, Shaikh, Mushfiq, additional, Fallaha, Sora, additional, Clarke, Daniel, additional, Kelly, Madison, additional, Sedelies, Karin, additional, Christensen, Melinda, additional, McKee, Sara, additional, Leggatt, Graham, additional, Leo, Paul, additional, Skalamera, Dubravka, additional, Soyer, H. Peter, additional, Gonda, Thomas J., additional, and McMillan, Nigel A.J., additional

Published
2015
Full Text
View/download PDF

46. MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells

Author

Plummer, Prue N., primary, Freeman, Ruth, additional, Taft, Ryan J., additional, Vider, Jelena, additional, Sax, Michael, additional, Umer, Brittany A., additional, Gao, Dingcheng, additional, Johns, Christopher, additional, Mattick, John S., additional, Wilton, Stephen D., additional, Ferro, Vito, additional, McMillan, Nigel A.J., additional, Swarbrick, Alexander, additional, Mittal, Vivek, additional, and Mellick, Albert S., additional

Published
2013
Full Text
View/download PDF

50. Polymeric siRNA delivery vectors: knocking down cancers with polymeric-based gene delivery systems.

Author

Ardana, Aditya, Whittaker, Andrew K., McMillan, Nigel A.J., and Thurecht, Kristofer J.

Subjects
SMALL interfering RNA, CANCER treatment, CANCER chemotherapy, ANTISENSE RNA, TUMOR treatment
Abstract

One of the most promising routes for cancer therapy that has evolved over the previous decade is the use of small-interfering RNA ( siRNA) as a means of switching off genes that are responsible for tumour development. However, while siRNA and gene/antisense therapies provide alternatives to conventional chemotherapies, significant hurdles related to the delivery and efficacy of treatment must still be overcome before this technology can be used as an effective treatment for cancer and other diseases. This review highlights the issues associated with siRNA therapy in vivo, and describes the various approaches that are being explored using polymers as delivery vectors. In particular, the review focuses on targeted delivery as a means of improving efficacy of the gene therapy. © 2014 Society of Chemical Industry [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results