Author: "McMaster University [Hamilton, Ontario]" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"McMaster University [Hamilton, Ontario]"' showing total 25,613 results

Start Over Author "McMaster University [Hamilton, Ontario]"

25,613 results on '"McMaster University [Hamilton, Ontario]"'

1. Signature sequences in diverse proteins provide evidence for the late divergence of the Order Aquificales

Author: Emma Griffiths; Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada, Radhey S. Gupta; Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada, Emma Griffiths; Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada, and Radhey S. Gupta; Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada
Abstract: The Aquificales species are presently believed to be the earliest branching lineage within Bacteria. However, the branching order of this group in different phylogenetic trees is highly variable and not resolved. In the present work, the phylogenetic placement of Aquificales was examined by means of a cladistic approach based on the shared presence or absence of definite signature sequences (consisting of conserved inserts or deletions) in many highly conserved and important proteins, e.g. RNA polymerase β(RpoB), RNA polymerase β´(RpoC), alanyl-tRNA synthetase (AlaRS), CTP synthase, inorganic pyrophosphatase (PPase), Hsp70 and Hsp60. For this purpose, fragments of the above genes that contained the signature regions were cloned from different Aquificales, species (Calderobacterium hydrogenophilum, Hydrogenobacter marinus, and Thermocrinis ruber) and the sequence data were compared with those available from all other species. The presence in Aquificales species of distinctive inserts in Hsp70 and Hsp60 that are not found in any Firmicutes, Actinobacteria, or Thermotoga-Clostridium species excluded them from these groups of Bacteria. The shared presence of prominent indels in the RpoB (>100 amino acids), RpoC (>100 amino acids) and AlaRS (4 amino acids) proteins, which are only found in the various Aquificales species, the Chlamydiae, the CFBG (Cytophaga- Flavobacteria-Bacteroides-green sulfur bacteria) group, and Proteobacteria, strongly suggests their placement within these groups of Bacteria. A specific relationship between Proteobacteria and Aquificales is suggested by the presence in inorganic pyrophosphatase of a 2-amino-acid insert that is uniquely found in these phyla. However, the Aquificales species lacked a number of other protein signatures (e.g. indels in CTP synthase and Hsp70) that are characteristic of Proteobacteria, indicating that they constitute a distinct phylum related to Proteobacteria. These results provide strong and consistent evidence that
Published: 2010

2. Definition and classification of hyperkinetic movements in childhood

Author: Nursing, School of Health Professions and Studies, University of Michigan, Flint, Michigan, USA, Deptartments of Biomedical Engineering, Biokinesiology, and Neurology, University of Southern California, Los Angeles, California, USA ; Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, DRB 140, Los Angeles, CA 90089-1111, Extramural Research Program, NIH/NINDS, Bethesda, Maryland, USA, Division of Developmental Paediatrics, University of Toronto, Toronto, Ontario, Canada, Human Motor Control Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA, Movement Disorders Center, Toronto Western Hospital and Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA, Pediatrics and Neurology, Child Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, Functional and Applied Biomechanics Section, NIH, Bethesda, Maryland, USA, Movement Disorders Clinic, Neuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel, Department of Bioengineering, Stanford University, Stanford, California, USA, Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Pediatrics and Neurology, Pediatric Movement Disorders, The Children's Hospital, University of Colorado, Aurora, Colorado, USA, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA, Neuropediatric Unit, Karolinska Institutet, Astrid Lindgren Children's Hospital, Stockholm, Sweden, Orthopaedic Hospital Center for Cerebral Palsy, Tarjan Center, University of California - Los Angeles, Los Angeles, California, USA, Movement Disorder and Tourette Syndrome Clinics, Child Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA, Department of Physical Therapy, Samuel Merritt University, Oakland, California, USA, Pediatric Rehabilitation Medicine, Gillette Children's Specialty Healthcare, St. Paul, Minnesota, USA, Departments of Neurology and Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA, Northwestern University Physical Therapy and Human Movement Sciences, Chicago, Illinois, USA, Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA, Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, Pediatrics, Developmental Pediatrics, McMaster University, Hamilton, Ontario, Canada, School of Physical Therapy, Slippery Rock University, Slippery Rock, Pennsylvania, USA, Department of Neurology, Columbia University Medical Center, New York, New York, USA, Department of Orthopedic Surgery, Stanford University Medical Center, Stanford, California, USA, Pediatric Neurology, Shriners Hospital for Children, Oregon Health & Science University, Portland, Oregon, USA, Biology, Electrical and Computer Engineering, and Physics, Northeastern University, Boston, Massachusettes, USA, Neurology and Pediatrics, Pediatric Motor Disorders Research Program, University of Utah School of Medicine, Salt Lake City, Utah, USA, Department of Biomedical Engineering and Division of Biokinesiology & Physical Therapy, The University of Southern California, Los Angeles, California, Sanger, Terence D., Chen, Daofen, Fehlings, Darcy L., Hallett, Mark, Lang, Anthony E., Mink, Jonathan W., Singer, Harvey S., Alter, Katharine, Ben-Pazi, Hilla, Butler, Erin E., Chen, Robert, Collins, Abigail, Dayanidhi, Sudarshan, Forssberg, Hans, Fowler, Eileen, Gilbert, Donald L., Gorman, Sharon L., Gormley, Mark E., Jinnah, H. A., Kornblau, Barbara, Krosschell, Kristin J., Lehman, Rebecca K., MacKinnon, Colum, Malanga, C. J., Mesterman, Ronit, Michaels, Margaret Barry, Pearson, Toni S., Rose, Jessica, Russman, Barry S., Sternad, Dagmar, Swoboda, Kathy J., Valero-Cuevas, Francisco, Nursing, School of Health Professions and Studies, University of Michigan, Flint, Michigan, USA, Deptartments of Biomedical Engineering, Biokinesiology, and Neurology, University of Southern California, Los Angeles, California, USA ; Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, DRB 140, Los Angeles, CA 90089-1111, Extramural Research Program, NIH/NINDS, Bethesda, Maryland, USA, Division of Developmental Paediatrics, University of Toronto, Toronto, Ontario, Canada, Human Motor Control Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA, Movement Disorders Center, Toronto Western Hospital and Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA, Pediatrics and Neurology, Child Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA, Functional and Applied Biomechanics Section, NIH, Bethesda, Maryland, USA, Movement Disorders Clinic, Neuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel, Department of Bioengineering, Stanford University, Stanford, California, USA, Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, Pediatrics and Neurology, Pediatric Movement Disorders, The Children's Hospital, University of Colorado, Aurora, Colorado, USA, Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, USA, Neuropediatric Unit, Karolinska Institutet, Astrid Lindgren Children's Hospital, Stockholm, Sweden, Orthopaedic Hospital Center for Cerebral Palsy, Tarjan Center, University of California - Los Angeles, Los Angeles, California, USA, Movement Disorder and Tourette Syndrome Clinics, Child Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA, Department of Physical Therapy, Samuel Merritt University, Oakland, California, USA, Pediatric Rehabilitation Medicine, Gillette Children's Specialty Healthcare, St. Paul, Minnesota, USA, Departments of Neurology and Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA, Northwestern University Physical Therapy and Human Movement Sciences, Chicago, Illinois, USA, Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA, Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, Pediatrics, Developmental Pediatrics, McMaster University, Hamilton, Ontario, Canada, School of Physical Therapy, Slippery Rock University, Slippery Rock, Pennsylvania, USA, Department of Neurology, Columbia University Medical Center, New York, New York, USA, Department of Orthopedic Surgery, Stanford University Medical Center, Stanford, California, USA, Pediatric Neurology, Shriners Hospital for Children, Oregon Health & Science University, Portland, Oregon, USA, Biology, Electrical and Computer Engineering, and Physics, Northeastern University, Boston, Massachusettes, USA, Neurology and Pediatrics, Pediatric Motor Disorders Research Program, University of Utah School of Medicine, Salt Lake City, Utah, USA, Department of Biomedical Engineering and Division of Biokinesiology & Physical Therapy, The University of Southern California, Los Angeles, California, Sanger, Terence D., Chen, Daofen, Fehlings, Darcy L., Hallett, Mark, Lang, Anthony E., Mink, Jonathan W., Singer, Harvey S., Alter, Katharine, Ben-Pazi, Hilla, Butler, Erin E., Chen, Robert, Collins, Abigail, Dayanidhi, Sudarshan, Forssberg, Hans, Fowler, Eileen, Gilbert, Donald L., Gorman, Sharon L., Gormley, Mark E., Jinnah, H. A., Kornblau, Barbara, Krosschell, Kristin J., Lehman, Rebecca K., MacKinnon, Colum, Malanga, C. J., Mesterman, Ronit, Michaels, Margaret Barry, Pearson, Toni S., Rose, Jessica, Russman, Barry S., Sternad, Dagmar, Swoboda, Kathy J., and Valero-Cuevas, Francisco
Abstract: Hyperkinetic movements are unwanted or excess movements that are frequently seen in children with neurologic disorders. They are an important clinical finding with significant implications for diagnosis and treatment. However, the lack of agreement on standard terminology and definitions interferes with clinical treatment and research. We describe definitions of dystonia, chorea, athetosis, myoclonus, tremor, tics, and stereotypies that arose from a consensus meeting in June 2008 of specialists from different clinical and basic science fields. Dystonia is a movement disorder in which involuntary sustained or intermittent muscle contractions cause twisting and repetitive movements, abnormal postures, or both. Chorea is an ongoing random-appearing sequence of one or more discrete involuntary movements or movement fragments. Athetosis is a slow, continuous, involuntary writhing movement that prevents maintenance of a stable posture. Myoclonus is a sequence of repeated, often nonrhythmic, brief shock-like jerks due to sudden involuntary contraction or relaxation of one or more muscles. Tremor is a rhythmic back-and-forth or oscillating involuntary movement about a joint axis. Tics are repeated, individually recognizable, intermittent movements or movement fragments that are almost always briefly suppressible and are usually associated with awareness of an urge to perform the movement. Stereotypies are repetitive, simple movements that can be voluntarily suppressed. We provide recommended techniques for clinical examination and suggestions for differentiating between the different types of hyperkinetic movements, noting that there may be overlap between conditions. These definitions and the diagnostic recommendations are intended to be reliable and useful for clinical practice, communication between clinicians and researchers, and for the design of quantitative tests that will guide and assess the outcome of future clinical trials. ?? 2010 Movement Disorder Society
Published: 2010

3. Plasma prolactin and severe premenstrual tension

Author: Mental Health Research Institute, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, U.S.A., Departments of Psychiatry and Neurosciences, McMaster University, Hamilton, Ontario, L8S 4J9, Canada, Department of Psychiatry, Harbor U.C.L.A. Medical Center, Torrance, CA 90509, U.S.A., Steiner, Meir, Haskett, Roger F., Carroll, Bernard J., Hays, Sally E., Rubin, Robert T., Mental Health Research Institute, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, U.S.A., Departments of Psychiatry and Neurosciences, McMaster University, Hamilton, Ontario, L8S 4J9, Canada, Department of Psychiatry, Harbor U.C.L.A. Medical Center, Torrance, CA 90509, U.S.A., Steiner, Meir, Haskett, Roger F., Carroll, Bernard J., Hays, Sally E., and Rubin, Robert T.
Abstract: It has been suggested that elevated luteal phase prolactin (PRL) levels may have an important role in causing some of the symptoms of the premenstrual tension syndrome (PMTS). Thirty-seven women suffering from severe premenstrual dysphoria were selected for this study. Single morning and afternoon serum PRL evaluations were performed during the follicular (day 9) and late luteal (day 26) phases of the menstrual cycle. PRL was measured by an established double antibody radioimmunoassay technique. All mean PRL values were within the normal range. Only afternoon mean PRL levels showed a tendency for a premenstrual increase. The significance of this statistical finding is unclear, since one-third of the subjects showed a decrease in premenstrual PRL levels. Twenty-four hour PRL secretory profiles recorded on days 9 and 26 in two women with extremely severe PMTS and in two asymptomatic matched control subjects also failed to show a significant correlation between PRL levels and PMTS. Thirty subjects participated in a treatment trial using bromocriptine. A marked rebound hyperprolactinemia was observed in a subgroup of women nine days after cessation of bromocriptine. This was associated with no detectable effect on mood, behaviour, or menstrual regularity. Thus, our data fail to show any specific relationship between PRL and PMTS.
Published: 2006

4. Multi-stage production with variable lot sizes and transportation of partial lots

Author: School of Management, University of Michigan-Dearborn, Dearborn, MI 48128, U.S.A., Faculty of Business, McMaster University, Hamilton, Ontario, Canada L8S 4M4, Drezner, Zvi, Szendrovits, Andrew Z., Wesolowsky, G.O., School of Management, University of Michigan-Dearborn, Dearborn, MI 48128, U.S.A., Faculty of Business, McMaster University, Hamilton, Ontario, Canada L8S 4M4, Drezner, Zvi, Szendrovits, Andrew Z., and Wesolowsky, G.O.
Abstract: This paper describes a model for a multi-stage production/inventory system where lots may be of different sizes. In addition, either completed lots or partial lots, called batches, may be transported to succeeding stages. The model incorporates constraints on lot and batch-sizes and thus provides a rather comprehensive set of possibilities for organizing a production/inventory system. A heuristic solution procedure is developed and is shown to be `close to optimal' by bounding.
Published: 2006

5. Toward personalization of asthma treatment according to trigger factors

Author: Luis Caraballo, Susanne Greber-Platzer, W. Pohl, Bulent Enis Sekerel, Valérie Siroux, Elena S. Fedenko, Natalia Ilina, Paolo Maria Matricardi, Harald Renz, Petra Pazderova, Zhanat Ispayeva, Elopy Sibanda, Kian Fan Chung, Nikolaos G. Papadopoulos, Hugo Van Bever, Marianne van Hage, Alexander Emelyanov, S. G. Makarova, Roxana S. Bumbacea, Carmen Panaitescu, Erika von Mutius, Faith H. A. Osier, Sebastian L. Johnston, Jin Lyu Sun, Gary W.K. Wong, R S Fassakhov, Ludmila P. Sizyakina, Kristina Borochova, Jiu-Yao Wang, Evgeny Beltyukov, Zhongshan Gao, Kari C. Nadeau, Antonina Karsonova, Marco Idzko, Snezhana Bychkovskaya, A.N. Pampura, Katarzyna Niespodziana, Peter Errhalt, Tatiana Baranovskaya, Dmitry Kudlay, M. Gotua, Natalia Astafyeva, Thomas Schlederer, Marek L. Kowalski, Rezeda Fayzullina, Musa Khaitov, Tetiana Umanets, Ksenja Riabova, Leyla Namazova-Baranova, Pedro Giavina-Bianchi, Ruby Pawankar, Mohamed-Ridha Barbouche, Zsolt Szépfalusi, Sergii Zaikov, Hae-Sim Park, Guillermo Horacio Docena, Irina Evsegneeva, Mihaela Zidarn, Michael Levin, Adnan Custovic, Jean Bousquet, Elena Kovzel, Paul M. O'Byrne, Daria Fomina, Oleksandr Nazarenko, Elena Borzova, Thomas Eiwegger, Olga Naumova, Gunilla Hedlin, Omer Kalayci, Rudolf Valenta, Vanitha Sampath, Angelika Berger, Margarita Vasileva, Alexander Karaulov, Graduate School, Medical Microbiology and Infection Prevention, AII - Inflammatory diseases, Salvy-Córdoba, Nathalie, Medizinische Universität Wien = Medical University of Vienna, Saratov State Medical University, Partenaires INRAE, Belarusian Medical Academy of Post-Graduate Education [Minsk] (BelMAPGE), Laboratoire d'immunologie clinique [Institut Pasteur de Tunis], Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), South Ural State Medical University, Russian Medical Academy for Continuous Medical Education [Moscow], Pirogov Russian National Research Medical University, Sechenov First Moscow State Medical University, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Humboldt University Of Berlin, Berlin Institute of Health (BIH), University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Krasnoyarsk State Medical University (KrasSMU), Universidad de Cartagena [Cartagena de Indias], National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Universidad Nacional de la Plata [Argentine] (UNLP), The Hospital for sick children [Toronto] (SickKids), North-Western State Medical University [St Petersburg, Russia], Krems University Hospital, Kazan Federal University (KFU), Bashkir State University (BASHEDU), NRC Institute of immunology FMBA, Moscow Russian federation, Zhejiang Gongshang University [Hangzhou] (ZJSU), Universidade de São Paulo = University of São Paulo (USP), Tbilisi State University, Astrid Lindgren Children's Hospital, Karolinska University Hospital [Stockholm], Karolinska Institutet [Stockholm], Al-Farabi Kazakh National University [Almaty] (KazNU), Faculty of Medicine [Hacettepe University], Hacettepe University = Hacettepe Üniversitesi, Nazarbayev University [Kazakhstan], Medical University of Łódź (MUL), University of Cape Town, Dmitry Rogachev National Research Center of Pediatric Hematology, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Sean N. Parker Center for Allergy and Asthma Research [Stanford], Stanford Medicine, Stanford University-Stanford University, Pirogov Russian National Reasearch Medical University Moscow, National Academy of Medical Sciences of Ukraine, Shupyk National Medical Academy of Postgraduate Education [Kiev] (SNMAPE), Michael DeGroote School of Medicine [Hamilton, ON, Canada], Faculty of Health Sciences [Hamilton, ON, Canada], McMaster University [Hamilton, Ontario]-McMaster University [Hamilton, Ontario], KEMRI-Wellcome Trust Research Programme (KWTRP), Pius Branzeu Clinical Emergency Hospital (OncoGen), University of Manchester [Manchester], National and Kapodistrian University of Athens (NKUA), Ajou University, Nippon Medical School [Tokyo, Japon], Hietzing Hospital, Karl Landsteiner Institute for Dermatological Research, Landesklinikum St. Poelten, University of Giessen and Marburg Lung Center [Gießen, Germany] (UGMLC), German Center for Lung Research, University of Zimbawe [Harare] (UZ), University of Zimbawe, National University of Science and Technology [Bulawayo], Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Southern Federal University [Rostov-on-Don] (SFEDU), Peking Union Medical College Hospital [Beijing] (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College, National University of Singapore (NUS), Center of Allergology and Clinical Immunology, Dr von Hauner Children's Hospital [Munich, Germany], Ludwig-Maximilians-Universität München (LMU), Helmholtz Centre Munich, German Centre for Lung Research, National Cheng Kung University Hospital [Tainan], The Chinese University of Hong Kong [Hong Kong], Respiratory and Allergic Diseases [Golnik, Slovenia], University Clinic of Respiratory and Allergic Diseases Golnik, University of Ljubljana, and Karl Landsteiner University of Health Sciences - Karl Landsteiner Privatuniversität für Gesundheitswissenschaften [Krems an der Donau, Austria]
Subjects: 0301 basic medicine, Allergy, MESH: Asthma, Rhinovirus, Asthma treatment, CHILDREN, EPITOPE, Disease, Microarray, medicine.disease_cause, sopenje, alergeni, Personalization, Atopy, 0302 clinical medicine, immune system diseases, astma, Immunology and Allergy, MESH: Animals, Precision Medicine, RISK, MESH: Rhinovirus, respiratorni znaki in simptomi, analiza mikromrež, Allergen, alergija in imunologija, SENSITIZATION, personalizirana medicina, Wheeze, rhinovirus, allergy and immunology, INFECTIONS, 1107 Immunology, wheeze, ATOPY, [SDV.IMM]Life Sciences [q-bio]/Immunology, medicine.symptom, Life Sciences & Biomedicine, Bioquímica, medicine.medical_specialty, MESH: Allergens, [SDV.IMM] Life Sciences [q-bio]/Immunology, precision medicine, Immunology, udc:616-097, MESH: Precision Medicine, 03 medical and health sciences, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, rinovirus, medicine, Animals, Humans, allergens, IMMUNOTHERAPY, Intensive care medicine, Asthma, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, MESH: Humans, Science & Technology, business.industry, Allergens, asthma, respiratory, medicine.disease, respiratory tract diseases, signs and symptoms, 030104 developmental biology, ANTIBODY, 030228 respiratory system, Ciencias Médicas, MESH: Biomarkers, microarray analysis, business, Biomarkers, RESPONSES
Abstract: Asthma is a severe and chronic disabling disease affecting more than 300 million people worldwide. Although in the past few drugs for the treatment of asthma were available, new treatment options are currently emerging, which appear to be highly effective in certain subgroups of patients. Accordingly, there is a need for biomarkers that allow selection of patients for refined and personalized treatment strategies. Recently, serological chip tests based on microarrayed allergen molecules and peptides derived from the most common rhinovirus strains have been developed, which may discriminate 2 of the most common forms of asthma, that is, allergen- and virus-triggered asthma. In this perspective, we argue that classification of patients with asthma according to these common trigger factors may open new possibilities for personalized management of asthma., La lista completa de autores que integran el documento puede consultarse en el archivo., Facultad de Ciencias Exactas
Published: 2020

6. Strain engineering in III-V photonic components through structuration of SiN x films

Author: Brahim Ahammou, Aysegul Abdelal, Jean-Pierre Landesman, Christophe Levallois, Peter Mascher, Department of Engineering Physics, McMaster University, Hamilton, Ontario, Institut des Fonctions Optiques pour les Technologies de l'informatiON (Institut FOTON), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), McMaster University [Hamilton, Ontario], Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 010302 applied physics, Process Chemistry and Technology, Physics::Optics, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, 7. Clean energy, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Condensed Matter::Materials Science, [SPI]Engineering Sciences [physics], 0103 physical sciences, Materials Chemistry, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Electrical and Electronic Engineering, 0210 nano-technology, Instrumentation, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; We describe work to quantify the effects of structured dielectric thin films, such as SiNx, at the surface of III-V semiconductors, in terms of strain engineering with applications to photonic components such as waveguides and lasers. We show that the strain in the semiconductor can be engineered by controlling the stress in the dielectric thin film by tuning its deposition process. In the first part of this study, we describe how we can control the amount of this built-in mechanical stress, in the case of SiNx, over a large range, from highly tensile (300 MPa) to highly compressive (-800 MPa), using two different kinds of plasma-enhanced chemical vapor deposition reactors: a standard capacitively-coupled reactor with radio-frequency excitation and an electron cyclotron resonance reactor with microwave excitation. We focused on characterizing and understanding these thin films' optical and chemical bonding properties through spectroscopic ellipsometry and Fourier transform infrared spectroscopy. We have also studied their mechanical properties experimentally using the wafer curvature measurement technique, microstructure fabrication, and nano-indentation measurements. In the second part, we show accurate
Published: 2022

7. Global prevalence and burden of meal-related abdominal pain

Author: Esther Colomier, Chloé Melchior, Joost P. Algera, Jóhann P. Hreinsson, Stine Störsrud, Hans Törnblom, Lukas Van Oudenhove, Olafur S. Palsson, Shrikant I. Bangdiwala, Ami D. Sperber, Jan Tack, Magnus Simrén, University of Gothenburg (GU), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Cognitive & Affective Neuroscience Lab (CANlab), Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USA., UNC Center for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, NC, USA., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada., Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada., Ben-Gurion University of the Negev (BGU), and douville, sabine
Subjects: Adult, Epidemiology, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Gastrointestinal Diseases, Functional gastrointestinal disorders, digestive, oral, and skin physiology, Burden, General Medicine, Gastrointestinal symptoms, Disorders of the gut-brain interaction, Abdominal Pain, Irritable Bowel Syndrome, Food, Surveys and Questionnaires, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Prevalence, Quality of Life, Global prevalence, Humans, Female, Meal-related abdominal pain
Abstract: Background Patients with disorders of gut-brain interaction (DGBI) report meal intake to be associated with symptoms. DGBI patients with meal-related symptoms may have more severe symptoms overall and worse health outcomes, but this subgroup has not been well characterized. We aimed to describe the global prevalence of meal-related abdominal pain and characterize this subgroup. Methods The data analyzed originated from the Internet survey component of the population-based Rome Foundation Global Epidemiology Study, completed in 26 countries (n = 54,127). Adult subjects were asked whether they had abdominal pain and how often this was meal-related. Respondents were categorized into “no,” “occasional,” and “frequent” meal-related abdominal pain groups based on 0%, 10–40%, and ≥50% of the pain episodes being meal-related, respectively. DGBI diagnoses, frequency of other GI symptoms, psychological distress, non-GI somatic symptoms, quality of life, and healthcare utilization were compared between groups. Mixed linear and ordinal regression was used to assess independent associations between psychological distress, non-GI somatic symptoms, quality of life, other GI symptoms, and meal-related abdominal pain. Results Overall, 51.9% of the respondents reported abdominal pain in the last 3 months, and 11.0% belonged to the group with frequent meal-related abdominal pain, which included more females and younger subjects. DGBI diagnoses were more common in subjects with frequent meal-related abdominal pain, and the frequency of several GI symptoms was associated with having more frequent meal-related abdominal pain. Having meal-related abdominal pain more frequently was also associated with more severe psychological distress, non-GI somatic symptoms, and a poorer quality of life. The group with frequent meal-related abdominal pain also more often consulted a doctor for bowel problems compared to the other groups of meal-related abdominal pain. Conclusion Reporting frequent meal-related abdominal pain is common across the globe and associated with other GI and non-GI somatic symptoms, psychological distress, healthcare utilization, and a poorer quality of life. Individuals who frequently experience meal-related abdominal pain also more frequently fulfill the diagnostic criteria for DGBI. Assessing meal-related symptoms in all DGBI patients could be of major importance to improve and individualize symptom management.
Published: 2021

8. Heart failure with preserved ejection fraction: recent concepts in diagnosis, mechanisms and management

Author: Andreas B Gevaert, Rachna Kataria, Faiez Zannad, Andrew J Sauer, Kevin Damman, Kavita Sharma, Sanjiv J Shah, Harriette G C Van Spall, Universiteit Antwerpen = University of Antwerpen [Antwerpen], Antwerp University Hospital [Edegem] (UZA), University Medical Center Groningen [Groningen] (UMCG), Massachusetts General Hospital [Boston, MA, USA], Harvard Medical School [Boston] (HMS), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), University of Kansas [Kansas City], Johns Hopkins University School of Medicine [Baltimore], Bluhm Cardiovascular Institute at Northwestern Memorial Hospital, Feinberg School of Medicine, Northwestern University [Evanston], McMaster University [Hamilton, Ontario], Population Health Research Institute, McMaster University [Hamilton, Ontario]-Hamilton General Hospital, ABG acknowledges funding from the European Society of Cardiology in form of an ESC Training Grant. SJS has received research grants from the National Institutes of Health (R01 HL107577, R01 HL127028, R01 HL140731, R01 HL149423). HGCV is funded by the Canadian Institutes of Health Research and the Heart and Stroke Foundation of Canada, and BOZEC, Erwan
Subjects: Heart Failure, Ventricular Dysfunction, Left, Angiotensins, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, cardiovascular system, Humans, Stroke Volume, Human medicine, Cardiology and Cardiovascular Medicine, Prognosis, Biology, Ventricular Function, Left, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Abstract: International audience; It is estimated that half of all patients with heart failure (HF) have HF with preserved ejection fraction (HFpEF). Yet this form of HF remains a diagnostic and therapeutic challenge. Differentiating HFpEF from other causes of dyspnoea may require advanced diagnostic methods, such as exercise echocardiography, invasive haemodynamics and investigations for ‘HFpEF mimickers’. While the classification of HF has relied heavily on cut-points in left ventricular ejection fraction (LVEF), recent evidence points towards a gradual shift in underlying mechanisms, phenotypes and response to therapies as LVEF increases. For example, among patients with HF, the proportion of hospitalisations and deaths due to cardiac causes decreases as LVEF increases. Medication classes that are efficacious in HF with reduced ejection fraction (HFrEF) have been less so at higher LVEF ranges, decreasing the risk of HF hospitalisation but not cardiovascular or all-cause death in HFpEF. These observations reflect the burden of non-cardiac comorbidities as LVEF increases and highlight the complex pathophysiological mechanisms, both cardiac and non-cardiac, underpinning HFpEF. Treatment with sodium-glucose cotransporter 2 inhibitors reduces the risk of composite cardiovascular events, driven by a reduction in HF hospitalisations; renin-angiotensin-aldosterone blockers and angiotensin-neprilysin inhibitors result in smaller reductions in HF hospitalisations among patients with HFpEF. Comprehensive management of HFpEF includes exercise as well as treatment of risk factors and comorbidities. Classification based on phenotypes may facilitate a more targeted approach to treatment than LVEF categorisation, which sets arbitrary cut-points when LVEF is a continuum. This narrative review summarises the pathophysiology, diagnosis, classification and management of patients with HFpEF.
Published: 2021

9. Nodal Sets and Morse Indices of Solutions of Super-linear Elliptic PDEs

Author: Yang, Xue-Feng
Published: 1998
Full Text: View/download PDF

10. Selective Area Growth by Hydride Vapor Phase Epitaxy and Optical Properties of InAs Nanowire Arrays

Author: Evelyne Gil, Eric Tournié, Kirsten E. Moselund, Ray R. LaPierre, Curtis Goosney, Nebile Isik Goktas, Yamina André, Heinz Schmid, Thierry Taliercio, Gabin Grégoire, Philipp Staudinger, Mohammed Zeghouane, Agnès Trassoudaine, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Department of Engineering Physics, McMaster University, Hamilton, Ontario, Department of Engineering Physics,McMaster University, Hamilton, Ontario L8S4L7, IBM Research Europe [Zürich], Institut d’Electronique et des Systèmes (IES), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Composants à Nanostructure pour le moyen infrarouge (NANOMIR), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 010302 applied physics, Materials science, business.industry, Hydride, Vapor phase, Nanowire, 02 engineering and technology, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Epitaxy, 01 natural sciences, 0103 physical sciences, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Optoelectronics, General Materials Science, 0210 nano-technology, business
Abstract: International audience; We report on the selective area growth of InAs nanowires (NWs) by the catalyst-free vapor−solid method. Well-ordered InAs NWs were grown on GaAs(111)B and Si(111) substrates patterned with a dielectric mask using hydride vapor phase epitaxy (HVPE). Vertical and high aspect ratio InAs NWs with a hexagonal shape were grown on both GaAs and Si substrates. The impact of the growth conditions on the InAs morphology was investigated. The final shape of the InAs crystal was tuned from a NW to a nanoplatelet by controlling growth conditions such as growth temperature, vapor phase composition, and mask pattern. The influence of the aperture size on the nucleation density and then on the morphology of InAs is discussed. Small openings resulted in the formation of a single nucleus per hole, which was then converted to a NW. For larger apertures, the number of nuclei increased, leading to both three-dimensional crystals and NWs. The effect of growth temperature and the III/V ratio on the kinetics and thermodynamics of InAs growth is also discussed. The growth was first optimized on a GaAs(111)B substrate and then performed on Si, which is more suitable to develop devices. Finally, the absorbance and photoluminescence measurements were carried out on the InAs NW arrays, demonstrating the high potential of HVPE-grown InAs NWs for future multispectral photo-detection devices.
Published: 2021

11. Acute kidney injury during an ultra-distance race

Author: Dany Anglicheau, Romain Jouffroy, Nicolas Mansencal, Xavier Lebreton, Anesthesiology and Intensive Care Unit [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-SAMU 75 [Paris]-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of Anesthesia, Clinical Epidemiology and Biostatistics [Hamilton, ON, Canada], Michael DeGroote School of Medicine [Hamilton, ON, Canada], Faculty of Health Sciences [Hamilton, ON, Canada], McMaster University [Hamilton, Ontario]-McMaster University [Hamilton, Ontario]-Faculty of Health Sciences [Hamilton, ON, Canada], McMaster University [Hamilton, Ontario]-McMaster University [Hamilton, Ontario], Perioperative Medicine and Surgical Research Unit [Hamilton, ON, Canada], David Braley Cardiac, Vascular and Stroke Research Institute [Hamilton, ON, Canada], Population Health Research Institute [Hamilton, ON, Canada]-Population Health Research Institute [Hamilton, ON, Canada], Laboratory of molecular mechanisms of hematologic disorders and therapeutic implications (ERL 8254 - Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche biomédicale et d’épidémiologie du sport (IRMES - EA 7329), Université Paris Descartes - Paris 5 (UPD5)-Institut national du sport, de l'expertise et de la performance (INSEP), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service Néphrologie et transplantation rénale Adultes [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de cardiologie et maladies vasculaires [CHU Ambroise Paré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Centre de Référence des Cardiomyopathies et des Troubles du Rythme Cardiaque Héréditaires ou Rares [Boulogne-Billancourt], Hôpital Ambroise Paré [AP-HP], Épidémiologie et recherches translationnelles sur les maladies rénales et cardiovasculaires (EPREC) (U1018 (Équipe 5)), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Bodescot, Myriam, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut de recherche biomédicale et d’épidémiologie du sport (IRMES - URP_7329), Institut national du sport, de l'expertise et de la performance (INSEP)-Université Paris Cité (UPCité), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Adult, Male, Physiology, Science, 030232 urology & nephrology, Renal function, Urine, 030204 cardiovascular system & hematology, Biochemistry, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Running, 03 medical and health sciences, Race (biology), chemistry.chemical_compound, 0302 clinical medicine, Complete regression, Chronic Kidney Disease, medicine, Medicine and Health Sciences, Humans, Creatinine, Multidisciplinary, business.industry, Significant difference, Acute kidney injury, Biology and Life Sciences, Kidneys, Renal System, Acute Kidney Injury, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Body Fluids, Urinary Biomarkers, Blood, chemistry, Nephrology, Creatinine increased, Medicine, Anatomy, business, Biomarkers, Research Article
Abstract: International audience; PURPOSE:Previous studies have noted consequences of ultra-distance trail running on health, but few studies are available regarding the temporal variations of renal biomarker injury during the running. The aim of this study was to assess the of kidney function parameters temporal variation during and on short-term after an ultra-distance race.METHODS:We performed an observational study with 47 subjects participating in an ultra-distance race (80 km). Urine (47 subjects) and blood (21 subjects) samples were serially collected before (baseline-km 0), during (21 and 53 km), on arrival (80 km), and 9 days after the race (d9).RESULTS:Mean serum creatinine increased during the race from 90±14 μmol/L (km0) to 136±32 μmol/L (km 80-p0.05). On day 9, no significant difference remains in blood and urine biomarkers compared to their respective baseline levels.CONCLUSIONS:During an ultra-distance race, despite an acute and transient increase in the serum creatinine levels, urinary biomarkers of AKI displayed only limited changes with a complete regression on day 9. These results suggest the absence of the short-term impact of an ultra-distance race kidney function.
Published: 2019

12. Effects of accelerated versus standard care surgery on the risk of acute kidney injury in patients with a hip fracture: a substudy protocol of the hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) international randomised controlled trial

Author: Borges, F.K., Devereaux, P.J., Cuerden, M., Bhandari, M., Guerra Farfan, Ernesto., Patel, A., Sigamani, A., Umer, M., Neary, J., Tiboni, M., Tandon, V., Ramokgopa, M.T., Sancheti, P., John, B., Lawendy, A., Balaguer-Castro, Mariano, Jenkinson, R., Ś Lȩczka, P., Nabi Nur, A., Wood, G.C.A., Feibel, R., McMahon, J.S., Biccard, B.M., Landoni, G., Szczeklik, W., Wang, C.Y., Tomas-Hernandez, Jordi, Abraham, V., Vincent, J., Harvey, V., Pettit, S., Sontrop, J., Garg, A.X., Universitat Autònoma de Barcelona, [Borges FK] Department of Medicine, McMaster University, Hamilton, Ontario, Canada. Department of Perioperative Medicine, Population Health Research Institute, Hamilton, Ontario, Canada. [Devereaux PJ] Department of Perioperative Medicine, Population Health Research Institute, Hamilton, Ontario, Canada. Departments of Health Research Methods, Evidence, and Impact (HEI), McMaster University, Hamilton, Ontario, Canada. [Cuerden M] Division of Nephrology, Department of Medicine, Western University, London, Ontario, Canada. [Bhandari M] Department of Surgery, McMaster University, Hamilton, Ontario, Canada. [Guerra-Farfán E, Tomas-Hernandez J] Servei de Cirurgia Traumatològica i Ortopèdica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Patel A] Department of Medicine, McMaster University, Hamilton, Ontario, Canada, Vall d'Hebron Barcelona Hospital Campus, Borges, F. K., Devereaux, P. J., Cuerden, M., Bhandari, M., Guerra-Farfan, E., Patel, A., Sigamani, A., Umer, M., Neary, J., Tiboni, M., Tandon, V., Ramokgopa, M. T., Sancheti, P., John, B., Lawendy, A., Balaguer-Castro, M., Jenkinson, R., Sleczka, P., Nabi Nur, A., Wood, G. C. A., Feibel, R., Mcmahon, J. S., Biccard, B. M., Landoni, G., Szczeklik, W., Wang, C. Y., Tomas-Hernandez, J., Abraham, V., Vincent, J., Harvey, V., Pettit, S., Sontrop, J., and Garg, A. X.
Subjects: Male, Therapeutics::Patient Care::Time-to-Treatment [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], accelerated surgery, 030232 urology & nephrology, Patient Care Planning, law.invention, Hip fracture, Fractures - Tractament, 0302 clinical medicine, Postoperative Complications, Randomized controlled trial, law, Fracture Fixation, Risk Factors, Protocol, Medicine, 030212 general & internal medicine, Surgical treatment, Acute kidney injury, Cirurgia ortopèdica, General Medicine, Acute Kidney Injury, 3. Good health, Insuficiència renal aguda, Therapeutics::Orthopedic Procedures [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], terapéutica::procedimientos ortopédicos [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], hip fracture, Female, Risk Adjustment, Adult, medicine.medical_specialty, enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::insuficiencia renal::lesión renal aguda [ENFERMEDADES], Risk Assessment, Time-to-Treatment, 03 medical and health sciences, Standard care, Humans, In patient, Surgical repair, Protocol (science), business.industry, Hip Fractures, medicine.disease, Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Acute Kidney Injury [DISEASES], Surgery, terapéutica::asistencia al paciente::tiempo hasta el tratamiento [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Accelerated surgery, business
Abstract: Accelerated surgery; Acute kidney injury; Hip fracture Cirugía acelerada; Lesión renal aguda; Fractura de cadera Cirurgia accelerada; Lesions renals agudes; Fractura de maluc Introduction: Inflammation, dehydration, hypotension and bleeding may all contribute to the development of acute kidney injury (AKI). Accelerated surgery after a hip fracture can decrease the exposure time to such contributors and may reduce the risk of AKI. Methods and analysis: Hip fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) is a multicentre, international, parallel-group randomised controlled trial (RCT). Patients who suffer a hip fracture are randomly allocated to either accelerated medical assessment and surgical repair with a goal of surgery within 6 hours of diagnosis or standard care where a repair typically occurs 24 to 48 hours after diagnosis. The primary outcome of this substudy is the development of AKI within 7 days of randomisation. We anticipate at least 1998 patients will participate in this substudy. Ethics and dissemination: We obtained ethics approval for additional serum creatinine recordings in consecutive patients enrolled at 70 participating centres. All patients provide consent before randomisation. We anticipate reporting substudy results by 2021. Trial registration number: NCT02027896; Pre-results. This work was supported by the following grants: Canadian Institute of Health and Research (CIHR) Foundation Award, CIHR’s Strategy for Patient Oriented Research (SPOR), through the Ontario SPOR Support Unit, which is supported by the CIHR and the Province of Ontario, as well as the Ontario Ministry of Health and Long-Term Care, and a grant from Smith & Nephew to recruit 300 patients in Spain. Grants to support this substudy were provided by the Department of Medicine at Western University. Dr Devereaux was supported by a Tier 1 Canada Research Chair in Perioperative Medicine. Dr Amit Garg was supported by the Dr Adam Linton Chair in Kidney Health Analytics and a CIHR Clinician Investigator Award.
Published: 2019

13. Rationale and design of the HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) Trial : a protocol for an international randomised controlled trial evaluating early surgery for hip fracture patients

Author: Benjamin Deheshi, Gavin C A Wood, Aamer Nabi Nur, Maria Tiboni, Leslie Gauthier, Ekaterine Popova, Masood Umer, Patrice Forget, Parag Sancheti, Flávia Kessler Borges, Alben Sigamani, Philip J. Devereaux, Iain K. Moppett, Mitchell Winemaker, Wojciech Szczeklik, Mohit Bhandari, Abdel-Rahman Lawendy, Richard Kolesar, Vikas Tandon, Mariano Balaguer-Castro, Paweł Ślęczka, Shirley Pettit, Jordi Teixidor-Serra, Victoria Avram, Michael McGillion, Giovanni Landoni, Valerie Harvey, Ernesto Guerra-Farfán, Chew Yin Wang, Bobby John, Jordi Tomas-Hernandez, Ameen Patel, Anthony Adili, John Neary, Robert J. Feibel, Justin de Beer, Mmampapatla Thomas Ramokgopa, Richard Jenkinson, Bruce M Biccard, Jessica Vincent, Kim Alvarado, Harsha Shanthanna, Institut Català de la Salut, [Borges FK] Department of Perioperative Medicine, Population Health Research Institute, Hamilton, Ontario, Canada. [Bhandari M, Avram V] Department of Surgery, McMaster University, Hamilton, Ontario, Canada. [Patel A] Department of Medicine, McMaster University, Hamilton, Ontario, Canada. [Guerra-Farfán E, Teixidor-Serra J, Tomas-Hernandez J] Servei de Cirurgia Ortopèdica i Traumatologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sigamani A] Department of Clinical Research, Narayana Health, Bangalore, India., Vall d'Hebron Barcelona Hospital Campus, Supporting clinical sciences, Anesthesiology, Borges, Flavia K, Bhandari, Mohit, Patel, Ameen, Avram, Victoria, Guerra-Farfán, Ernesto, Sigamani, Alben, Umer, Masood, Tiboni, Maria, Adili, Anthony, Neary, John, Tandon, Vika, Sancheti, Parag K, Lawendy, Abdelrahman, Jenkinson, Richard, Ramokgopa, Mmampapatla, Biccard, Bruce M, Szczeklik, Wojciech, Wang, Chew Yin, Landoni, Giovanni, Forget, Patrice, Popova, Ekaterine, Wood, Gavin, Nabi Nur, Aamer, John, Bobby, Ślęczka, Paweł, Feibel, Robert J, Balaguer-Castro, Mariano, Deheshi, Benjamin, Winemaker, Mitchell, de Beer, Justin, Kolesar, Richard, Teixidor-Serra, Jordi, Tomas-Hernandez, Jordi, Mcgillion, Michael, Shanthanna, Harsha, Moppett, Iain, Vincent, Jessica, Pettit, Shirley, Harvey, Valerie, Gauthier, Leslie, Alvarado, Kim, and Devereaux, P J
Subjects: Male, Time Factors, accelerated surgery, law.invention, 0302 clinical medicine, Postoperative Complications, Randomized controlled trial, law, Informed consent, Protocol, 030212 general & internal medicine, Stroke, Medicine(all), Hip fracture, Mortality rate, Wounds and Injuries::Fractures, Bone::Femoral Fractures::Hip Fractures [DISEASES], General Medicine, Middle Aged, Other subheadings::Other subheadings::/surgery [Other subheadings], 3. Good health, Pulmonary embolism, Research Design, hip fracture, randomised control trial, Female, medicine.medical_specialty, heridas y lesiones::fracturas óseas::fracturas del fémur::fracturas de cadera [ENFERMEDADES], 03 medical and health sciences, Health Care Facilities, Manpower, and Services::Health Services::Preventive Health Services::Early Medical Intervention [HEALTH CARE], medicine, Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics::Clinical Protocols::Clinical Trial Protocols as Topic [HEALTH CARE], Humans, Articulació coxofemoral - Cirurgia, Aged, business.industry, Hip Fractures, Otros calificadores::Otros calificadores::/cirugía [Otros calificadores], Perioperative, medicine.disease, calidad, acceso y evaluación de la atención sanitaria::calidad de la atención sanitaria::mecanismos de evaluación de la atención sanitaria::características de los estudios epidemiológicos::protocolos clínicos::protocolos de ensayos clínicos como asunto [ATENCIÓN DE SALUD], Physical therapy, instalaciones, servicios y personal de asistencia sanitaria::servicios de salud::servicios preventivos de salud::intervención médica temprana [ATENCIÓN DE SALUD], Observational study, Surgery, business, 030217 neurology & neurosurgery, Assaigs clínics
Abstract: IntroductionAnnually, millions of adults suffer hip fractures. The mortality rate post a hip fracture is 7%–10% at 30 days and 10%–20% at 90 days. Observational data suggest that early surgery can improve these outcomes in hip fracture patients. We designed a clinical trial—HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) to determine the effect of accelerated surgery compared with standard care on the 90-day risk of all-cause mortality and major perioperative complications.Methods and analysisHIP ATTACK is a multicentre, international, parallel group randomised controlled trial (RCT) that will include patients ≥45 years of age and diagnosed with a hip fracture from a low-energy mechanism requiring surgery. Patients are randomised to accelerated medical assessment and surgical repair (goal within 6 h) or standard care. The co-primary outcomes are (1) all-cause mortality and (2) a composite of major perioperative complications (ie, mortality and non-fatal myocardial infarction, pulmonary embolism, pneumonia, sepsis, stroke, and life-threatening and major bleeding) at 90 days after randomisation. All patients will be followed up for a period of 1 year. We will enrol 3000 patients.Ethics and disseminationAll centres had ethics approval before randomising patients. Written informed consent is required for all patients before randomisation. HIP ATTACK is the first large international trial designed to examine whether accelerated surgery can improve outcomes in patients with a hip fracture. The dissemination plan includes publishing the results in a policy-influencing journal, conference presentations, engagement of influential medical organisations, and providing public awareness through multimedia resources.Trial registration numberNCT02027896; Pre-results.
Published: 2019

14. Mobile technology offers novel insights into the control and treatment of allergic rhinitis: The MASK study

Author: Niels H. Chavannes, Oliver Pfaar, Peter Valentin Tomazic, Antonio Valero, Jean-François Fontaine, Sara Shamai, Gabrielle L. Onorato, Jane da Silva, Ralph Mösges, I. Annesi-Maesano, Piotr Kuna, Violeta Kvedariene, Sanna Toppila-Salmi, Arunas Valiulis, Rute Almeida, Philippe Devillier, Rafael Stelmach, Regina Roller-Wirnsberger, Sietze Reitsma, Tari Haahtela, Ioana Agache, Ruth Murray, Claus Bachert, Gert De Vries, Michael Makris, Esben Eller, Carsten Bindslev-Jensen, Josep M. Antó, João O. Malva, R. Emuzyte, Benoit Pugin, Arzu Yorgancioglu, Ana Todo-Bom, Enrica Menditto, Wienczyslawa Czarlewski, Isabelle Bosse, Ana Margarida Pereira, Mário Morais-Almeida, Cemal Cingi, Emmanuel P. Prokopakis, Ingrid Kull, José Miguel Fuentes-Pérez, Mike Bewick, João Fonseca, Alvaro A. Cruz, Aziz Sheikh, Annabelle Bédard, Mark S. Dykewicz, Xavier Basagaña, Anna Bedbrook, Sinthia Bosnic-Anticevich, Ludger Klimek, Jean Bousquet, Magnus Wickman, Joaquim Mullol, Susan Waserman, Cristiana Stellato, Dermot Ryan, Judith Garcia-Aymerich, Erik Melén, Dana Wallace, Yunuen Rocío Huerta-Villalobos, Thomas B. Casale, Sylvie Arnavielhe, Bilun Gemicioglu, Daniel Laune, Fotis Psarros, Nikos G. Papadopoulos, Bolesław Samoliński, Maria Teresa Ventura, Erkka Valovirta, Robyn E O'Hehir, Peter Hellings, V. Cardona, Michiel van Eerd, Pascal Demoly, Wytske Fokkens, Elísio Costa, Ignacio J. Ansotegui, Désirée Larenas-Linnemann, ISGlobal, Barcelona, Spain, Universitat Pompeu Fabra (UPF), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, UPRES EA220, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France, KYomed INNOV, Montpellier, France, MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France, Medical Consulting Czarlewski, Levallois, France, Medical Communications Consultant, MedScript, Dundalk, and OPC, Cambridge, United Kingdom, Center for Health Technology and Services Research–CINTESIS, Faculdade de Medicina, Universidade do Porto, and Medida, Porto, Portugal, UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal, Institute of Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, and the Ageing@Coimbra EIP-AHA Reference Site, Coimbra, Portugal, Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal, Allergy Unit, CUF-Porto Hospital and Institute, and the Center for Research in Health Technologies and information systems CINTESIS, Universidade do Porto, Porto, Portugal, Imunoalergologia, Centro Hospitalar Universitário de Coimbra and Faculty of Medicine, University of Coimbra, Coimbra, Portugal, CIRFF, Federico II University, Naples, Italy, Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Salerno, Italy, Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy, ProAR–Nucleo de Excelencia em Asma, Federal University of Bahia, and the WHO GARD Planning Group, Brazil, Pulmonary Division, Heart Institute (InCor), Hospital da Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil, Department of Internal Medicine and Allergy Clinic of Professor Polydoro Ernani de São Thiago University Hospital, Federal University of Santa Catarina (UFSC), Florianopolis, Brazil, Center of Excellence in Asthma and Allergy, Hospital Médica Sur, México City, Mexico, Hospital General Region 1, Dr Carlos Mc Gregor Sanchez Navarro' IMSS, Mexico City, Mexico, Clinic of Children's Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania, Faculty of Medicine, Vilnius University, Vilnius, Lithuania, Vilnius University Institute of Clinical Medicine, Clinic of Children's Diseases, and the Institute of Health Sciences, Department of Public Health, Vilnius, Lithuania, European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium, Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland, Center for Rhinology and Allergology, Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, Institute of Medical Statistics, and Computational Biology, Medical Faculty, University of Cologne, and CRI-Clinical Research International, Hamburg, Germany, University Hospital, Montpellier, France, Department of Otorhinolaryngology, Head and Neck Surgery, Section for Rhinology and Allergy, University Hospital Marburg, Phillipps-Universität, Marburg, Germany, Epidemiology of Allergic and Respiratory Diseases, Department Institute Pierre Louis of Epidemiology and Public Health, INSERM and UPMC Sorbonne Université, Medical School Saint Antoine, Paris, France, Allergist, La Rochelle, France, Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France, Allergist, Reims, France, Allergy Section, Department of Internal Medicine, Hospital Vall'dHebron & ARADyAL Research Network, Barcelona, Spain, Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, and Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain, Pneumology and Allergy Department CIBERES and Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, University of Barcelona, Barcelona, Spain, Department of Internal Medicine, Medical University of Graz, Graz, Austria, Department of ENT, Medical University of Graz, Graz, Austria, Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands, Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, Netherlands, iQ4U Consultants, London, United Kingdom, Allergy and Respiratory Research Group, University of Edinburgh, Edinburgh, United Kingdom, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom, Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland, Department of Lung Diseases and Clinical Immunology, University of Turku and Terveystalo allergy clinic, Turku, Finland, Allergy Unit 'D Kalogeromitros', 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, 'Attikon' University Hospital, Athens, Greece, Center for Pediatrics and Child Health, Institute of Human Development, Royal Manchester Children's Hospital, University of Manchester, and UK Allergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital 'P&A Kyriakou', University of Athens, Athens, Greece, Department of Otorhinolaryngology University of Crete School of Medicine, Heraklion, Greece, Allergy Department, Athens Naval Hospital, Athens, Greece, Eskisehir Osmangazi University, Medical Faculty, ENT Department, Eskisehir, Turkey, Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey, Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa (and the GARD Executive Committee), Manisa, Turkey, Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia, Woolcock Emphysema Centre and Local Health District, Glebe, Australia, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Central Clinical School, and the Department of Immunology, Monash University, Melbourne, Australia, Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent, Belgium, Department of Otorhinolaryngology, University Hospitals Leuven, and the Academic Medical Center, University of Amsterdam, and Euforea, Brussels, Belgium, European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Brussels, Belgium, Department of Dermatology and Allergy Centre, Odense University Hospital, Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark, Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, and Sach's Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden, Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Centre for Clinical Research Sörmland, Uppsala University, Eskilstuna, Sweden, Peercode BV, Geldermalsen, Netherlands, Transylvania University Brasov, Brasov, Romania, Department of Allergy and Immunology, Hospital Quirón Bizkaia, Erandio, Spain, Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, Mo, United States, Division of Allergy/Immunology, University of South Florida, Tampa, Fla, United States, Nova Southeastern University, Fort Lauderdale, Fla, United States, Department of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada, INSERM U 1168, VIMA: Ageing and chronic diseases Epidemiological and Public Health Approaches, Villejuif, Université Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, and Euforea, Brussels, Belgium, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), Hôpital Foch [Suresnes], Kyomed, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), MedScript Ltd, Universidade do Porto, Centre for Research in Health Technologies and Information Systems (CINTESIS), Instituto de Biologia Molecular e Celular (IBMC), University of Coimbra [Portugal] (UC), Allergy and Clinical Immunology Department, Hospital CUF-Descobertas, 'Federico II' University of Naples Medical School, Università degli studi di Bari Aldo Moro (UNIBA), Universidade Federal da Bahia (UFBA), Hospital Medica Sur, Vilnius University [Vilnius], Vilnius University Clinic of Children's Diseases, Medical University of Łódź (MUL), Medical University of Warsaw - Poland, Center for Rhinology and Allergology, Institute of Medical Statistics, Informatics and Epidemiology (IMSIE), University of Cologne, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Vall d'Hebron University Hospital [Barcelona], Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Medical University Graz, iQ4U consultants Ltd, University of Edinburgh, University of Helsinki, Suomen Terveystalo Allergy Clinic, Eskisehir Osmangazi University, Cerrahpasa Faculty of Medicine, Istanbul University, Department of Pulmonology, Manisa Celal Bayar University, Woolcock Institute of Medical Research [Sydney], The University of Sydney, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital-Monash University Building, AMREP, Ghent University Hospital, University Hospitals Leuven [Leuven], Department of Dermatology and Allergy Centre, Odense University Hospital, Institute of Environmental Medicine [Stockholm, Sweden], Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm]-Astrid Lindgren Children's Hospital, Peercode (Développement de l'application) Oudenhof 4c 4191 NW Geldermalsen, Pays-Bas., Department of Allergy and Clinical Immunology, Transylvania University of Brasov, Department of Allergy and Immunology, Hospital Quiròn Bizkaia Erandio, Saint Louis University School of Medicine [St Louis], University of South Florida [Tampa] (USF), Nova Southeastern University (NSU), McMaster University [Hamilton, Ontario], Hôpital Arnaud de Villeneuve [CHRU Montpellier], Department of Dermatology, Allergology and Venereology, HUS Inflammation Center, Ear, Nose and Throat, AII - Inflammatory diseases, Bedard, A., Basagana, X., Anto, J. M., Garcia-Aymerich, J., Devillier, P., Arnavielhe, S., Bedbrook, A., Onorato, G. L., Czarlewski, W., Murray, R., Almeida, R., Fonseca, J., Costa, E., Malva, J., Morais-Almeida, M., Pereira, A. M., Todo-Bom, A., Menditto, E., Stellato, C., Ventura, M. T., Cruz, A. A., Stelmach, R., da Silva, J., Larenas-Linnemann, D., Fuentes-Perez, J. M., Huerta-Villalobos, Y. R., Emuzyte, R., Kvedariene, V., Valiulis, A., Kuna, P., Samolinski, B., Klimek, L., Mosges, R., Pfaar, O., Shamai, S., Annesi-Maesano, I., Bosse, I., Demoly, P., Fontaine, J. -F., Cardona, V., Mullol, J., Valero, A., Roller-Wirnsberger, R. E., Tomazic, P. V., Chavannes, N. H., Fokkens, W. J., Reitsma, S., Bewick, M., Ryan, D., Sheikh, A., Haahtela, T., Toppila-Salmi, S., Valovirta, E., Makris, M., Papadopoulos, N. G., Prokopakis, E. P., Psarros, F., Cingi, C., Gemicioglu, B., Yorgancioglu, A., Bosnic-Anticevich, S., O'Hehir, R. E., Bachert, C., Hellings, P. W., Pugin, B., Bindslev-Jensen, C., Eller, E., Kull, I., Melen, E., Wickman, M., De Vries, G., van Eerd, M., Agache, I., Ansotegui, I. J., Dykewicz, M. S., Casale, T., Wallace, D., Waserman, S., Laune, D., and Bousquet, J.
Subjects: Male, Allergy, Lydia Becker Institute, Visual Analog Scale, IMPACT, Efficiency, THERAPY, Allergic rhinitis, law.invention, corticosteroids, FLUTICASONE, 0302 clinical medicine, Randomized controlled trial, law, Adrenal Cortex Hormones, conjunctiviti, conjunctivitis, Immunology and Allergy, AZELASTINE, 030212 general & internal medicine, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, Child, Aged, 80 and over, treatment, Middle Aged, WORK PRODUCTIVITY, Mobile Applications, 3. Good health, Child, Preschool, GUIDED SELF-MANAGEMENT, Histamine H1 Antagonists, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Symptom Assessment, medicine.drug, Adult, corticosteroid, medicine.medical_specialty, antihistamines, MASK, Adolescent, Visual analogue scale, Immunology, Mometasone furoate, antihistamine, Fluticasone propionate, 03 medical and health sciences, Young Adult, ResearchInstitutes_Networks_Beacons/lydia_becker_institute_of_immunology_and_inflammation, asthma, mobile health, Allergic rhiniti, medicine, QUALITY, Humans, Asthma, Aged, business.industry, Infant, Newborn, Infant, medicine.disease, Azelastine, Rhinitis, Allergic, 030228 respiratory system, 3121 General medicine, internal medicine and other clinical medicine, Physical therapy, Observational study, business, TRADITIONAL TREATMENT
Abstract: Demoly, Pascal/0000-0001-7827-7964; Chavannes, Niels/0000-0002-8607-9199; Basagana, Xavier/0000-0002-8457-1489; N.G., Papadopoulos/0000-0002-4448-3468; Almeida, Rute/0000-0001-7755-5002; Pereira, Ana Margarida/0000-0002-5468-0932; Gemicioglu, Bilun/0000-0001-5953-4881; Bedard, Annabelle/0000-0002-7842-8889; Anto, J M/0000-0002-4736-8529; Fonseca, Joao Almeida/0000-0002-0887-8796; Rodo, Xavier/0000-0003-4843-6180; stelmach, rafael/0000-0002-5132-1934; J, Garcia-Aymerich/0000-0002-7097-4586; orlando, valentina/0000-0002-8209-8878; Cardona, Victoria/0000-0003-2197-9767; yorgancioglu, arzu/0000-0002-4032-0944; Bindslev-Jensen, Carsten/0000-0002-8940-038X; VENTURA, Maria Teresa/0000-0002-2637-4583; O'Hehir, Robyn/0000-0002-3489-7595; Costa, Elisio/0000-0003-1158-1480; Malva, Joao/0000-0002-5438-4447; Pugin, Benoit/0000-0001-7132-9477; Psarros, Fotis/0000-0002-2928-150X; Kuna, Piotr/0000-0003-2401-0070 WOS:000473432800017 PubMed ID: 30951790 Background: Mobile health can be used to generate innovative insights into optimizing treatment to improve allergic rhinitis (AR) control. Objectives: A cross-sectional real-world observational study was undertaken in 22 countries to complement a pilot study and provide novel information on medication use, disease control, and work productivity in the everyday life of patients with AR. Methods: A mobile phone app (Allergy Diary, which is freely available on Google Play and Apple stores) was used to collect the data of daily visual analogue scale (VAS) scores for (1) overall allergic symptoms; (2) nasal, ocular, and asthma symptoms; (3) work; and (4) medication use by using a treatment scroll list including all allergy medications (prescribed and over-the-counter) customized for 22 countries. The 4 most common intranasal medications containing intranasal corticosteroids and 8 oral H-1-antihistamines were studied. Results: Nine thousand one hundred twenty-two users filled in 112,054 days of VASs in 2016 and 2017. Assessment of days was informative. Control of days with rhinitis differed between no (best control), single (good control for intranasal corticosteroid-treated days), or multiple (worst control) treatments. Users with the worst control increased the range of treatments being used. The same trend was found for asthma, eye symptoms, and work productivity. Differences between oral H-1-antihistamines were found. Conclusions: This study confirms the usefulness of the Allergy Diary in accessing and assessing behavior in patients with AR. This observational study using a very simple assessment tool (VAS) on a mobile phone had the potential to answer questions previously thought infeasible. Sanofi AventisSanofi-Aventis; GlaxoSmithKlineGlaxoSmithKline; North Portugal Regional Operational Programme; European Regional Development Fund (ERDF)European Union (EU); Mundipharm; Teva Pharma; AstraZenecaAstraZeneca; Boehringer IngelheimBoehringer Ingelheim; Chiesi; MEDA Pharma; Sao Paulo Research FoundationFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); NovartisNovartis; Chiesi, DBV Technologies; UCBUCB Pharma SA; SanofiSanofi-Aventis; Adamed; FAES, Berlin Chemie; ALK-Abello; Allergopharma, Allergy Therapeutics; ServierServier; ASIT biotech; Hulka; Leti and Stallergenes; Roxall, Atmos, Bionorica; ALK-Abello, Allergopharma, Stallergenes Greer, HAL Allergy Holding B.V./HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics; Biomay, Nuvo, Circassia; Novartis Pharma; Mundipharma; RocheRoche Holding; Erkko Foundation; Hal Allergy B. V.; Teva; Meda, Stallergenes; Cipla; Mundipharma, Mylan; Sanofi-AventisSanofi-Aventis P. Devillier reports personal fees from Sanofi Aventis, GlaxoSmithKline, AstraZeneca, Chiesi, Meda Pharma, and Menarini outside the submitted work. R. Almeida reports grants from Project NORTE-01-0145-FEDER-000016 (NanoSTIMA) by the North Portugal Regional Operational Programme (NORTE 2020) under the Portugal 2020 Partnership Agreement and through the European Regional Development Fund (ERDF) during the conduct of the study. A. Todo-Bom reports grants and personal fees from GlaxoSmithKline, Mundipharm, and Novartis; personal fees from Teva Pharma and AstraZeneca; and grants from Leti and Bial outside the submitted work. A. A. Cruz reports grants and personal fees from AstraZeneca; grants from GlaxoSmithKline; personal fees from Boehringer Ingelheim, Chiesi, Novartis, Eurofarma, MEDA Pharma, and Boston Scientific outside the submitted work. R. Stelmach reports grants from the Sao Paulo Research Foundation and MSD; grants and personal fees from Novartis, grants, personal fees, and nonfinancial support from AstraZeneca and Chiesi; and personal fees and nonfinancial support from Boehringer Ingelheim outside the submitted work. D. Larenas-Linnemann reports personal fees from Armstrong, AstraZeneca, Boehringer Ingelheim, Chiesi, DBV Technologies, Grunenthal, GlaxoSmithKline, MEDA, Menarini, MSD, Novartis, Pfizer, Sanofi, Siegfried, and UCB and grants from Sanofi, AstraZeneca, Novartis, UCB, GlaxoSmithKline, TEVA, Boehringer Ingelheim, and Chiesi outside the submitted work. V. Kvedariene has received payment for consultancy from GlaxoSmithKline and for lectures from StallergensGreer and Berlin-Chemie outside the submitted work. P. Kuna reports personal fees from Adamed, Boehringer Ingelheim, AstraZeneca, Chiesi, FAES, Berlin Chemie, Novartis, Polpharma, and Allergopharma outside the submitted work. R. Mosges reports personal fees from ALK-Abello, Allergopharma, Allergy Therapeutics, Hexal, Servier, Klosterfrau, Stada, UCB, and Friulchem; grants from ASIT biotech, Nuvo, Bayer, FAES, GlaxoSmithKline, MSD, Johnson & Johnson, Meda, Optima, Ursapharm, BitopAG, and Hulka; grants and personal fees from Bencard; grants from Leti and Stallergenes; grants, personal fees and nonfinancial support from Lofarma; nonfinancial support from Roxall, Atmos, Bionorica, Otonomy, and Ferrero; and personal fees and nonfinancial support from Novartis outside the submitted work. O. Pfaar reports grants and personal fees from ALK-Abello, Allergopharma, Stallergenes Greer, HAL Allergy Holding B.V./HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, and Lofarma; grants from Biomay, Nuvo, Circassia, and GlaxoSmithKline; and personal fees from Novartis Pharma, MEDA Pharma, Indoor Biotechnologies, and Pohl-Boskamp outside the submitted work. T. Haahtela reports personal fees from Mundipharma, Novartis, and Orion Pharma outside the submitted work. S. Toppila-Salmi reports other support from Biomedical Systems and Roche and grants from the Erkko Foundation outside the submitted work. N. G. Papadopoulos reports grants from Gerolymatos and personal fees from Hal Allergy B. V., Novartis Pharma AG, Menarini, Hal Allergy B. V., and Mylan outside the submitted work. S. Bosnic-Anticevich reports personal fees from Teva, Boehringer Ingelheim, Sanofi, GlaxoSmithKline, and AstraZeneca outside the submitted work. C. Bachert reports personal fees from Meda, Stallergenes, and ALK-Abello (speaker). I. J. Ansotegui reports personal fees from Hikma, Roxall, AstraZeneca, Menarini, UCB, Faes Farma, Sanofi, and Mundipharma outside the submitted work. D.; Wallace reports other from Mylan Pharmaceutical Company outside the submitted work being co-chair of the AAAAI/ACAAI Joint Task Force on Practice Parameters. J. Bousquet reports personal fees and other support from Chiesi, Cipla, Hikma, Menarini, Mundipharma, Mylan, Novartis, Sanofi-Aventis, Takeda, Teva, and Uriach outside the submitted work and other support from Kyomed. The rest of the authors declare that they have no relevant conflicts of interest.
Published: 2018

15. Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study

Author: Stephen J. Vanner, Iradj Maleki, Ammar Hassanzadeh Keshteli, Payman Adibi, Olafur S. Palsson, Dan L. Dumitrascu, Sandie R Thomson, Douglas A. Drossman, William E. Whitehead, Aurelio López-Colombo, Mashiko Setshedi, Max Schmulson, Yeong Yeh Lee, Bruno Bonaz, Oksana Stefanyuk, Jan Tack, Eamonn Martin Quigley, Enrico Corazziari, Valeria Costa, Edith N. Okeke, Magnus Simren, Timothy N. Archampong, John Kellow, Luis M. Bustos Fernandez, Uday C Ghoshal, Shrikant I. Bangdiwala, Nitesh Pratap, Viola Andresen, Motoyori Kanazawa, Suck Chei Choi, Rutaba Khatun, Leonid Lazebnik, Serhat Bor, Ram Dickman, M Masudur Rahman, Xuicai Fang, Pierre Poitras, Reuben K. Wong, Ami D. Sperber, Carlos Fernando de Magalhães Francisconi, Shin Fukudo, Peter J. Whorwell, Marc A. Benninga, Agata Mulak, Albis Hani, Javier Santos, Ari Fahrial Syam, Judith Zeevenhooven, Institut Català de la Salut, [Sperber AD] Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. [Bangdiwala SI] Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada. [Drossman DA] Center for Functional GI & Motility Disorders, University of North Carolina, Center for Education and Practice of Biopsychosocial Care, and Drossman Gastroenterology, Chapel Hill, North Carolina. [Ghoshal UC] Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow, India. [Simren M] Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. [Tack J] Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium. [Santos J] Servei d’Aparell Digestiu, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Laboratori de Neuro-Inmuno-Gastroenterologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Paediatric Gastroenterology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, ARD - Amsterdam Reproduction and Development, and Ege Üniversitesi
Subjects: Adult, Male, atención a la salud (salud pública)::salud de grupos específicos::salud global [SALUD PÚBLICA], 0301 basic medicine, Patient-Reported Outcomes Measurement Information System, medicine.medical_specialty, Adolescent, Gastrointestinal Diseases, Other subheadings::Other subheadings::/epidemiology [Other subheadings], Global Health, Enquestes, Características de la Población::demografía::estadísticas vitales::morbilidad::prevalencia [ATENCIÓN DE SALUD], Population Characteristics::Demography::Vital Statistics::Morbidity::Prevalence [HEALTH CARE], Young Adult, enfermedades del sistema digestivo::enfermedades gastrointestinales [ENFERMEDADES], 03 medical and health sciences, Age Distribution, 0302 clinical medicine, Functional gastrointestinal disorder, Quality of life, Surveys and Questionnaires, IBS, Health care, Epidemiology, Prevalence, Humans, Medicine, Sex Distribution, Health Care (Public Health)::Health of Specific Groups::Global Health [PUBLIC HEALTH], Irritable bowel syndrome, Aged, Salut mundial, DGBI, Hepatology, business.industry, Otros calificadores::Otros calificadores::/epidemiología [Otros calificadores], Gastroenterology, Odds ratio, Middle Aged, medicine.disease, Confidence interval, 030104 developmental biology, Female, 030211 gastroenterology & hepatology, epidemiology, Tracte gastrointestinal - Malalties - Epidemiologia, Digestive System Diseases::Gastrointestinal Diseases [DISEASES], business, Demography
Abstract: BACKGROUND & AIMS: Although functional gastrointestinal disorders (FGIDs), now called disorders of gut-brain interaction, have major economic effects on health care systems and adversely affect quality of life, little is known about their global prevalence and distribution. We investigated the prevalence of and factors associated with 22 FGIDs, in 33 countries on 6 continents. METHODS: Data were collected via the Internet in 24 countries, personal interviews in 7 countries, and both in 2 countries, using the Rome IV diagnostic questionnaire, Rome III irritable bowel syndrome questions, and 80 items to identify variables associated with FGIDs. Data collection methods differed for Internet and household groups, so data analyses were conducted and reported separately. RESULTS: Among the 73,076 adult respondents (49.5% women), diagnostic criteria were met for at least 1 FGID by 40.3% persons who completed the Internet surveys (95% confidence interval [CI], 39.9-40.7) and 20.7% of persons who completed the household surveys (95% CI, 20.2-21.3). FGIDs were more prevalent among women than men, based on responses to the Internet survey (odds ratio, 1.7; 95% CI, 1.6-1.7) and household survey (odds ratio, 1.3; 95% CI, 1.3-1.4). FGIDs were associated with lower quality of life and more frequent doctor visits. Proportions of subjects with irritable bowel syndrome were lower when the Rome IV criteria were used, compared with the Rome III criteria, in the Internet survey (4.1% vs 10.1%) and household survey (1.5% vs 3.5%). CONCLUSIONS: in a large-scale multinational study, we found that more than 40% of persons worldwide have FGIDs, which affect quality of life and health care use. Although the absolute prevalence was higher among Internet respondents, similar trends and relative distributions were found in people who completed Internet vs personal interviews., Ironwood; Shire; AllerganAllergan; TakedaTakeda Pharmaceutical Company Ltd; Fundamental Research Grant Scheme (FRGS) of the Ministry of Education of Malaysia [203.PPSP.6171192]; Takeda-Israel; Romanian Society of Neurogastroenterology, The study was funded, in part, by research grants from Ironwood, Shire, Allergan, and Takeda. The study in Malaysia was funded by the Fundamental Research Grant Scheme (FRGS) of the Ministry of Education of Malaysia (Reference: 203.PPSP.6171192). The study in Israel was funded by Takeda-Israel. The study in Romania was funded by the Romanian Society of Neurogastroenterology. None of the funders was involved in the planning, design, implementation, statistical analyses or any other aspect of the study including preparation of the paper or knowledge of its contents.
Published: 2021

16. The importance of gene–environment interactions in human obesity

Author: Hudson Reddon, David Meyre, Jean-Louis Guéant, Department of Clinical Epidemiology and Biostatistics [Hamilton, ON, Canada], McMaster University [Hamilton, Ontario]-Michael DeGroote Centre for Learning & Discovery, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Department of Pathology and Molecular Medicine [Hamilton, ON, Canada], McMaster University [Hamilton, Ontario], D. M. holds a Canada Research Chair in Genetics of Obesity., and Meyre, David
Subjects: 0301 basic medicine, obesity, Polygenic Obesity, polygenic, [SDV.GEN] Life Sciences [q-bio]/Genetics, heritability, Biology, Article, Developmental psychology, 03 medical and health sciences, monogenic, medicine, Animals, Humans, Measurement precision, Genetic Predisposition to Disease, Gene–environment interaction, Life Style, Human obesity, Genetics, [SDV.GEN]Life Sciences [q-bio]/Genetics, business.industry, Confounding, methodology, gene-environment interactions, General Medicine, gene–environment interactions, medicine.disease, Obesity, Genetic architecture, 3. Good health, 030104 developmental biology, Gene-Environment Interaction, Personalized medicine, business
Abstract: International audience; The worldwide obesity epidemic has been mainly attributed to lifestyle changes. However, who becomes obese in an obesity-prone environment is largely determined by genetic factors. In the last 20 years, important progress has been made in the elucidation of the genetic architecture of obesity. In parallel with successful gene identifications, the number of gene–environment interaction (GEI) studies has grown rapidly. This paper reviews the growing body of evidence supporting gene–environment interactions in the field of obesity. Heritability, monogenic and polygenic obesity studies provide converging evidence that obesity-predisposing genes interact with a variety of environmental, lifestyle and treatment exposures. However, some skepticism remains regarding the validity of these studies based on several issues, which include statistical modelling, confounding, low replication rate, underpowered analyses, biological assumptions and measurement precision. What follows in this review includes (1) an introduction to the study of GEI, (2) the evidence of GEI in the field of obesity, (3) an outline of the biological mechanisms that may explain these interaction effects, (4) methodological challenges associated with GEI studies and potential solutions, and (5) future directions of GEI research. Thus far, this growing body of evidence has provided a deeper understanding of GEI influencing obesity and may have tremendous applications in the emerging field of personalized medicine and individualized lifestyle recommendations.
Published: 2016

17. Peste noire, sélection naturelle et susceptibilité aux maladies auto-immunes ou auto-inflammatoires

Author: Christian E. Demeure, Hendrik Poinar, Luis Barreiro, Javier Pizarro-Cerdá, Yersinia, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), McMaster University [Hamilton, Ontario], University of Chicago, and NIH
Subjects: [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], génétique humaine, peste noire, [SDV.IMM]Life Sciences [q-bio]/Immunology, General Medicine, sélection naturelle, ERAP2, General Biochemistry, Genetics and Molecular Biology
Abstract: International audience; No abstract available
Published: 2023

18. Evolution of immune genes is associated with the Black Death

Author: Jennifer Klunk, Tauras P. Vilgalys, Christian E. Demeure, Xiaoheng Cheng, Mari Shiratori, Julien Madej, Rémi Beau, Derek Elli, Maria I. Patino, Rebecca Redfern, Sharon N. DeWitte, Julia A. Gamble, Jesper L. Boldsen, Ann Carmichael, Nükhet Varlik, Katherine Eaton, Jean-Christophe Grenier, G. Brian Golding, Alison Devault, Jean-Marie Rouillard, Vania Yotova, Renata Sindeaux, Chun Jimmie Ye, Matin Bikaran, Anne Dumaine, Jessica F. Brinkworth, Dominique Missiakas, Guy A. Rouleau, Matthias Steinrücken, Javier Pizarro-Cerdá, Hendrik N. Poinar, Luis B. Barreiro, McMaster Ancient DNA Center [Hamilton, Ontario], McMaster University [Hamilton, Ontario], Daicel Arbor Biosciences [Ann Arbor, MI], University of Chicago, Yersinia, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Museum of London, University of South Carolina [Columbia], University of Manitoba [Winnipeg], University of Southern Denmark (SDU), Indiana University [Bloomington], Indiana University System, Rutgers University [Newark], Rutgers University System (Rutgers), Université de Montréal (UdeM), University of Michigan [Ann Arbor], University of Michigan System, Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada], Université de Montréal (UdeM)-CHU Sainte Justine [Montréal], University of California [San Francisco] (UC San Francisco), University of California (UC), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, McGill University = Université McGill [Montréal, Canada], and This work was supported by grant R01-GM134376 to L.B.B., H.P. and J.P.-C., a grant from the Wenner-Gren Foundation to J.F.B. (8702), and the UChicago DDRCC, Center for Interdisciplinary Study of Inflammatory Intestinal Disorders (C-IID) (NIDDK P30 DK042086). The SSHRC Insight Development Grant supported the collection of the Danish samples (430-2017-01193). H.N.P. was supported by an Insight Grant no. 20008499 from the Social Sciences and Humanities Research Council of Canada (SSHRC) and The Canadian Institute for Advanced Research under the Humans and the Microbiome programme. T.P.V. was supported by NIH F32GM140568. X.C. and M. Steinrücken were supported by grant R01GM146051. We also thank the University of Chicago Genomics Facility (RRID:SCR_019196), especially P. Faber, for their assistance with RNA sequencing. H.P. thanks D. Poinar for continued support and manuscript suggestions and editing.
Subjects: Yersinia pestis, General Science & Technology, Denmark, Datasets as Topic, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, Aminopeptidases, Ancient, Genetic, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, London, Genetics, Humans, Genetic Predisposition to Disease, DNA, Ancient, Selection, Genetic, Selection, Plague, Multidisciplinary, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Prevention, Immunity, DNA, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Europe, Vector-Borne Diseases, Emerging Infectious Diseases, Infectious Diseases, Good Health and Well Being, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, Infection
Abstract: International audience; Infectious diseases are among the strongest selective pressures driving human evolution1,2. This includes the single greatest mortality event in recorded history, the first outbreak of the second pandemic of plague, commonly called the Black Death, which was caused by the bacterium Yersinia pestis3. This pandemic devastated Afro-Eurasia, killing up to 30-50% of the population4. To identify loci that may have been under selection during the Black Death, we characterized genetic variation around immune-related genes from 206 ancient DNA extracts, stemming from two different European populations before, during and after the Black Death. Immune loci are strongly enriched for highly differentiated sites relative to a set of non-immune loci, suggesting positive selection. We identify 245 variants that are highly differentiated within the London dataset, four of which were replicated in an independent cohort from Denmark, and represent the strongest candidates for positive selection. The selected allele for one of these variants, rs2549794, is associated with the production of a full-length (versus truncated) ERAP2 transcript, variation in cytokine response to Y. pestis and increased ability to control intracellular Y. pestis in macrophages. Finally, we show that protective variants overlap with alleles that are today associated with increased susceptibility to autoimmune diseases, providing empirical evidence for the role played by past pandemics in shaping present-day susceptibility to disease.
Published: 2022

19. Ni-Cu bimetallic catalytic membranes for continuous nitrophenol conversion

Author: Nan Zhang, Yichen Wu, Abdelrahman M. Awad, Emmanuel Doelsch, Charles-François de Lannoy, McMaster University [Hamilton, Ontario], Recyclage et risque (UPR Recyclage et risque), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Département Performances des systèmes de production et de transformation tropicaux (Cirad-PERSYST), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: General Chemical Engineering, [SDE]Environmental Sciences, Environmental Chemistry, General Chemistry, Industrial and Manufacturing Engineering
Abstract: International audience; Bimetallic nanocatalysts are of great interest due to their greater activity, selectivity, and chemical and electrochemical stability, compared to their monometallic counterparts. Bimetallic nanocatalysts formed from abundant and inexpensive elements provide greater opportunities for applications over noble metal catalysts. In this study, inexpensive Ni-Cu bimetallic catalytic membrane microreactors (CMMRs) were synthesized in a simple two-step process to catalytically degrade the environmental pollutant, 4-nitrophenol (4-NP), and produce the valuable feedstock, 4-aminophenol (4-AP). Ni-Cu nanoparticles were either produced by a replacement reduction reaction or a co-reduction reaction, producing either bimodal or integrated nanostructures, respectively, as demonstrated by transmission electron microscopy (TEM), while the electronic reconfiguration between bimetallic systems was verified by X-ray photoelectron spectroscopy (XPS). Compared to 4-NP batch conversion, flow-through reactions demonstrated enhanced mass transfer contributing to 2-fold higher conversion (>99%), 30-fold higher processing capacity (0.95 mol∙m−2∙h−1) and co-reduced Ni-Cu CMMRs boasted a reaction rate constant of 725.03 min−1.4-NP conversion on the Ni-Cu catalysts in the presence of NaBH4 followed the Langmuir-Hinshelwood (L-H) mechanism, and the conversion efficiency was highly dependent on flow rate, representing an optimization trade-off critical for CMMR applications. The polydopamine-assisted fabrication and the tortuous membrane pore structure contributed to the CMMRs’ stability with
Published: 2023

20. Degree of polarization of luminescence from InP under SiN stripes: fits to FEM simulations

Author: Cassidy, Daniel, Landesman, Jean-Pierre, McMaster University [Hamilton, Ontario], Institut des Fonctions Optiques pour les Technologies de l'informatiON (Institut FOTON), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: stress, [SPI]Engineering Sciences [physics], strain, degree of polarization (DOP), GaAs, cathodoluminescence (CL), SiN stripe
Abstract: International audience; Fits of 3D finite element method (FEM) simulations to the degree of polarization (DOP) of photoluminescence (PL) measured on facets under SiN stripes on InP substrates are presented. The measured data is low noise and the fits are remarkably good; lobes owing to defects (perhaps dislocations) can be seen in false colour maps of the residues from the least squares fits. It is found that the vast majority (estimated to be > 99%) of the DOP patterns can be attributed to an initial condition for the FEM simulations of biaxial strain in the SiN stripes. In addition to the fits of FEM simulations to the data and discussion of the fits: fits of error functions to PL data to find the resolution of the optical system and the location of the top surface, quantities that are required in fits of 3D FEM simulations to the data, are presented; as is presented some historical information on analysis of luminescent III-V materials and devices by analysis of the DOP of the luminescence, and some information on the dependence of the DOP of luminescence on strain for InP.
Published: 2023

21. Design and fabrication of color-generating nitride based thin-film optical filters for photovoltaic applications

Author: Paramita Bhattacharyya, Brahim Ahammou, Fahmida Azmi, Rafael Kleiman, Peter Mascher, McMaster University [Hamilton, Ontario], Institut des Fonctions Optiques pour les Technologies de l'informatiON (Institut FOTON), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS), NSERC CREATE TOP-SET Program (NSERC) [497981], and NSERC Discovery Grant [RGPIN-2019-06023]
Subjects: [SPI]Engineering Sciences [physics], Surfaces and Interfaces, Condensed Matter Physics, Surfaces, Coatings and Films
Abstract: International audience; In this paper, we present the design and fabrication of a 11-layer notch filter for photovoltaic applications. Thickness modulation has been done on a starting quarter-wave design to obtain a 11-layer final structure. For our design parameters, we considered materials with indices of 2.09 and 1.51 as high and low refractive index materials, respectively. Since this filter aims for photovoltaic applications, we defined the substrate as silicon. The design shows a reflection peak of around 73% from 350 to 467 nm with a FWHM of 79 nm along with less than 10% reflection for longer wavelengths of the remaining high transmission region of 300-1200 nm. For fabrication, we used silicon nitride and silicon oxynitride as alternating high and low refractive index materials on a silicon substrate. Layers of silicon nitride and oxynitride were deposited with an electron cyclotron resonance plasma-enhanced chemical vapor deposition reactor and characterized with variable angle spectroscopic ellipsometry and spectrophotometry.
Published: 2023

22. Degree of Polarization of Cathodoluminescence from a GaAs Facet in the Vicinity of an SiN Stripe

Author: Daniel T. Cassidy, Jean-Pierre Landesman, Merwan Mokhtari, Philippe Pagnod-Rossiaux, Marc Fouchier, Christian Monachon, McMaster University [Hamilton, Ontario], Institut des Fonctions Optiques pour les Technologies de l'informatiON (Institut FOTON), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS), 3SP Technologies, and Attolight AG
Subjects: stress, [SPI]Engineering Sciences [physics], strain, degree of polarization (DOP), General Health Professions, degree of polarization (DOP) cathodoluminescence (CL) GaAs SiN stripe stress strain, GaAs, cathodoluminescence (CL), SiN stripe
Abstract: International audience; Measurements of the cathodoluminescence (CL) and the degree of polarization (DOP) of (CL) from the facet of a GaAs substrate and in the vicinity of a SiN stripe are reported and analyzed. The deformation induced by the SiN stripe is estimated by fitting the measured DOP to 3D finite element method (FEM) simulations. The deformation is found to be more complex than an initial condition of biaxial stress in the SiN. A ratio of fit coefficients suggests that the dependence of DOP on strain is described by equations presented in Appl. Opt. 59, 5506-5520 (2020). These equations give a DOP that is either proportional to a weighted difference of the principal components of strain in the measurement plane, or proportional to the shear strain in the measurement plane, depending on the chosen orientation of the measurement axes.
Published: 2023
Full Text: View/download PDF

23. SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants

Author: Rixing Lin, Aron Kos, Juan Pablo Lopez, Julien Dine, Laura M. Fiori, Jennie Yang, Yair Ben-Efraim, Zahia Aouabed, Pascal Ibrahim, Haruka Mitsuhashi, Tak Pan Wong, El Cherif Ibrahim, Catherine Belzung, Pierre Blier, Faranak Farzan, Benicio N. Frey, Raymond W. Lam, Roumen Milev, Daniel J. Müller, Sagar V. Parikh, Claudio Soares, Rudolf Uher, Corina Nagy, Naguib Mechawar, Jane A. Foster, Sidney H. Kennedy, Alon Chen, Gustavo Turecki, McGill Group for Suicide Studies, McGill University = Université McGill [Montréal, Canada]-Douglas Mental Health University Institute, Max Plank Institute of Psychiatry, Department of Stress Neurobiology and Neurogenetics, Department of Brain Sciences, Weizmann Institute of Science, Neuroscience Division, Douglas Research Centre, Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), UMR 1253 IBrain Imagerie & Cerveau Equipe 1 : 'Psychiatrie Neuro-Fonctionnelle' (PNF), Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Mood Disorders Research Unit, University of Ottawa Institute of Mental Health Research, eBrain Lab, Simon Fraser University, Department of Psychiatry and Behavioural Neurosciences, McMaster University [Hamilton, Ontario], Department of Psychiatry, University of British Columbia, Departments of Psychiatry and Psychology, Queens University, Centre for Mental Health, Department of Psychiatry, University Health Network, Krembil Research Institute, University of Toronto, University of Michigan Hospital, Department of Psychiatry, Nova Scotia Health Authority, Mood Disorders Program, St. Joseph's Healthcare Hamilton, and St Michael’s Hospital, Li Ka Shing Knowledge Institute, Centre for Depression and Suicide Studies, Toronto
Subjects: [SDV]Life Sciences [q-bio]
Abstract: International audience; Pharmacotherapies for the treatment of major depressive disorder were serendipitously discovered almost seven decades ago. From this discovery, scientists pinpointed the monoaminergic system as the primary target associated with symptom alleviation. As a result, most antidepressants have been engineered to act on the monoaminergic system more selectively, primarily on serotonin, in an effort to increase treatment response and reduce unfavorable side effects. However, slow and inconsistent clinical responses continue to be observed with these available treatments. Recent findings point to the glutamatergic system as a target for rapid acting antidepressants. Investigating different cohorts of depressed individuals treated with serotonergic and other monoaminergic antidepressants, we found that the expression of a small nucleolar RNA, SNORD90 , was elevated following treatment response. When we increased Snord90 levels in the mouse anterior cingulate cortex (ACC), a brain region regulating mood responses, we observed antidepressive-like behaviors. We identified neuregulin 3 ( NRG3 ) as one of the targets of SNORD90 , which we show is regulated through the accumulation of N 6 -methyladenosine modifications leading to YTHDF2-mediated RNA decay. We further demonstrate that a decrease in NRG3 expression resulted in increased glutamatergic release in the mouse ACC. These findings support a molecular link between monoaminergic antidepressant treatment and glutamatergic neurotransmission.
Published: 2023

24. Magnetoelastic interactions in SrCu2(BO3)2 studied by Raman scattering experiments and first principles calculations

Author: Thirunavukkuarasu, K., Radtke, G., Lu, Z., Lazzeri, M., Christianen, P., Ballottin, M., Dabkowska, H., Gaulin, B., Smirnov, D., Jaime, M., Saúl, A., Department of Physics, Alabama A & M University, Huntsville, AL 35811, United States, Cosmochimie [IMPMC] (IMPMC_COSMO), Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Florida State University [Tallahassee] (FSU), Radboud University [Nijmegen], McMaster University [Hamilton, Ontario], Los Alamos National Laboratory (LANL), Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS]Physics [physics]
Abstract: International audience; Dynamic and static crystal lattice properties of SrCu2(BO3)2 are studied by means of Raman scattering, magnetostriction, and thermal expansion measurements in magnetic fields to 45 T. Raman experiments versus temperature reveal that some phonon modes show an unusual behavior, their frequencies soften (modes at 200 and 450 cm −1) while others harden (modes at 385 and 478 cm −1) when decreasing the temperature below 15 K. Magneto-Raman experiments show that their field dependence correlates with their respective temperature dependencies, e.g. modes that are hardened with increasing temperature also harden with applied magnetic fields and modes that become softer with temperature also soften with applied fields. We use density functional theory to successfully model and compute the energies of these modes, classifying them in two types: pantograph (modes that when decreasing the temperature) and non-pantograph. We conclude that the former involves the modification of the intra-dimer exchange interaction J and the latter the interdimer J ′. Finally, dilatometry is used to correlate field-dependent Raman modes to the closing of the spin gap as well as fractional-magnetization stripe states M = 1/4 Ms, and M = 1/3 Ms, where Ms is the saturation magnetization.
Published: 2023

25. Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke

Author: Sacco, Rl, Diener, Hc, Yusuf, S, Cotton, D, Ounpuu, S, Lawton, Wa, Palesch, Y, Martin, Rh, Albers, Gw, Bath, P, Bornstein, N, Chan, Bp, Chen, St, Cunha, L, Dahlöf, B, DE KEYSER, J, Donnan, Ga, Estol, C, Gorelick, P, Gu, V, Hermansson, K, Hilbrich, L, Kaste, M, Lu, C, Machnig, T, Pais, P, Roberts, R, Skvortsova, V, Teal, P, Toni, Danilo, Vandermaelen, C, Voigt, T, Weber, M, Yoon, Bw, Lembo, Giuseppe, Rasura, Maurizia, Sacchetti, Maria Luisa, Faculteit Medische Wetenschappen/UMCG, Gerontology, Department of neurology, University of Miami Leonard M. Miller School of Medicine (UMMSM)-University of Miami [Coral Gables], Universität Duisburg-Essen [Essen], Boehringer Ingelheim GmbH, Boehringer Ingelheim Pharmaceuticals, Population Health Research Institute, McMaster University [Hamilton, Ontario]-Hamilton General Hospital, Boehringer Ingelheim, Boehringer Ingelheim Ltd, Department of biostatistics, Bioinformatics and Epidemiology, Medical University of South Carolina [Charleston] (MUSC), Neurology and Neurological Sciences, Stanford University, Stroke Trials Unit, University of Nottingham, UK (UON), Neurology Department, Ichilov Medical Center, Division of Neurology, Department of Medicine, National University Hospital Singapore, Department of Neurology, Chang Gung Memorial Hospital [Taipei] (CGMH), Neurology department, Universidade de Coimbra [Coimbra], Institute of Medicine, Sahlgrenska University Hospital [Gothenburg], University Medical Center Groningen [Groningen] (UMCG), National Stroke Research Institute, University of Melbourne, Neurological Center for Treatment and Research, Department of Neurology and Rehabilitation, University of Illinois System, Boehringer Ingelheim Shanghai Pharmaceuticals Co Ltd, Boehringer Ingelheim AB, Helsinki University Central Hospital, Huashan Hospital [Shangai], Saint John's Medical College, Clinical Trials Methodoloy Group, McMaster University [Hamilton, Ontario], Neurology & Neurosurgery Clinic, Russian State Medical University, Department of Medicine, Neurology, Faculty of Medicine, University of British Columbia (UBC), Department of Neurological Sciences, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Cardiology Department, SUNY Downstate Medical Center, State University of New York (SUNY)-State University of New York (SUNY), Seoul National University Hospital, Service de Neurologie [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale et Comparée (NETEC), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM), Université de Limoges (UNILIM)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Sacco, Rl, Diener, Hc, Yusuf, S, Cotton, D, Ounpuu, S, Lawton, Wa, Palesch, Y, Martin, Rh, Albers, Gw, Bath, P, Bornstein, N, Chan, Bp, Chen, St, Cunha, L, Dahlof, B, DE KEYSER, J, Donnan, Ga, Estol, C, Gorelick, P, Gu, V, Hermansson, K, Hilbrich, L, Kaste, M, Lu, C, Machnig, T, Pais, P, Roberts, R, Skvortsova, V, Teal, P, Toni, D, Vandermaelen, C, Voigt, T, Weberm, Yoon, Bw, and Comi, Giancarlo
Subjects: Male, Myocardial Infarction, Angiotensin-Converting Enzyme Inhibitors, MESH: Cognition, Brain Ischemia, NON-INFERIORITY TRIALS, 0302 clinical medicine, aspirina, Secondary Prevention, Aspirin, MESH: Middle Aged, MESH: Risk, Hazard ratio, MESH: Disability Evaluation, MESH: Brain Ischemia, Dipyridamole, MESH: Follow-Up Studies, ARTERIAL ORIGIN ESPRIT, General Medicine, RANDOMIZED CONTROLLED-TRIAL, 3. Good health, MESH: Myocardial Infarction, Platelet aggregation inhibitor, Drug Therapy, Combination, MESH: Hemorrhage, medicine.medical_specialty, MESH: Ticlopidine, MESH: Delayed-Action Preparations, MESH: Drug Delivery Systems, MESH: Factor Analysis, Statistical, Hemorrhage, MESH: Drug Administration Schedule, MESH: Stroke, 03 medical and health sciences, MESH: Severity of Illness Index, Humans, Vascular Diseases, ACTIVE CONTROLLED-TRIALS, MESH: Kaplan-Meier Estimate, Aged, ictus, trial clinico, MESH: Humans, Proportional hazards model, MESH: Angiotensin II Type 1 Receptor Blockers, MESH: Retrospective Studies, medicine.disease, MESH: Benzoates, PREVENTION, MESH: International Cooperation, Delayed-Action Preparations, Benzimidazoles, Factor Analysis, Statistical, MESH: Mental Status Schedule, MESH: Female, 030217 neurology & neurosurgery, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Benzoates, MESH: Proportional Hazards Models, DOUBLE-BLIND, MESH: Double-Blind Method, Telmisartan, Stroke, MESH: Aged, MESH: Angiotensin-Converting Enzyme Inhibitors, Middle Aged, Clopidogrel, MESH: Platelet Aggregation Inhibitors, Anesthesia, MESH: Vascular Diseases, Cardiology, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.drug, Risk, Double-Blind Method, TICLOPIDINE, Internal medicine, medicine, cardiovascular diseases, MESH: Aspirin, Ticlopidine, HIGH-RISK PATIENTS, Proportional Hazards Models, CEREBRAL-ISCHEMIA, business.industry, MESH: Male, MESH: Recurrence, MESH: Drug Therapy, Combination, TRANSIENT ISCHEMIC ATTACK, MESH: Dipyridamole, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Benzimidazoles, business, Platelet Aggregation Inhibitors
Abstract: Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial; International audience; BACKGROUND: Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens--aspirin plus extended-release dipyridamole (ASA-ERDP) versus clopidogrel. METHODS: In this double-blind, 2-by-2 factorial trial, we randomly assigned patients to receive 25 mg of aspirin plus 200 mg of extended-release dipyridamole twice daily or to receive 75 mg of clopidogrel daily. The primary outcome was first recurrence of stroke. The secondary outcome was a composite of stroke, myocardial infarction, or death from vascular causes. Sequential statistical testing of noninferiority (margin of 1.075), followed by superiority testing, was planned. RESULTS: A total of 20,332 patients were followed for a mean of 2.5 years. Recurrent stroke occurred in 916 patients (9.0%) receiving ASA-ERDP and in 898 patients (8.8%) receiving clopidogrel (hazard ratio, 1.01; 95% confidence interval [CI], 0.92 to 1.11). The secondary outcome occurred in 1333 patients (13.1%) in each group (hazard ratio for ASA-ERDP, 0.99; 95% CI, 0.92 to 1.07). There were more major hemorrhagic events among ASA-ERDP recipients (419 [4.1%]) than among clopidogrel recipients (365 [3.6%]) (hazard ratio, 1.15; 95% CI, 1.00 to 1.32), including intracranial hemorrhage (hazard ratio, 1.42; 95% CI, 1.11 to 1.83). The net risk of recurrent stroke or major hemorrhagic event was similar in the two groups (1194 ASA-ERDP recipients [11.7%], vs. 1156 clopidogrel recipients [11.4%]; hazard ratio, 1.03; 95% CI, 0.95 to 1.11). CONCLUSIONS: The trial did not meet the predefined criteria for noninferiority but showed similar rates of recurrent stroke with ASA-ERDP and with clopidogrel. There is no evidence that either of the two treatments was superior to the other in the prevention of recurrent stroke. (ClinicalTrials.gov number, NCT00153062.)
Published: 2008

26. Uranium(<scp>iv</scp>) alkyl cations: synthesis, structures, comparison with thorium(<scp>iv</scp>) analogues, and the influence of arene-coordination on thermal stability and ethylene polymerization activity

Author: Nicholas R. Andreychuk, Balamurugan Vidjayacoumar, Jeffrey S. Price, Sophie Kervazo, Craig A. Peeples, David J. H. Emslie, Valérie Vallet, André S. P. Gomes, Florent Réal, Georg Schreckenbach, Paul W. Ayers, Ignacio Vargas-Baca, Hilary A. Jenkins, James F. Britten, Department of Chemistry, McMaster University, McMaster University [Hamilton, Ontario], Physico-Chimie Moléculaire Théorique (PCMT), Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (PhLAM), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), University of Manitoba [Winnipeg], NSERC of Canada for a Discovery Grant, Digital Research Alliance of Canada (previously Compute Canada) for a 2020 Resources for Research Groups (RRG) grant, NSERC, Digital Research Alliance of Canada, Canada Research Chairs for funding and computational resources, Government of Ontario for an Ontario Graduate Scholarship (OGS), McMaster University for a Richard Fuller Memorial Scholarship, ANR-11-LABX-0005,Cappa,Physiques et Chimie de l'Environnement Atmosphérique(2011), and ANR-16-IDEX-0004,ULNE,ULNE(2016)
Subjects: [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM.POLY]Chemical Sciences/Polymers, [CHIM.CRIS]Chemical Sciences/Cristallography, [CHIM.COOR]Chemical Sciences/Coordination chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, General Chemistry
Abstract: International audience; Reaction of [(XA2)U(CH2SiMe3)2] (1; XA2 = 4,5-bis(2,6-diisopropylanilido)-2,7-di-tert-butyl-9,9- dimethylxanthene) with 1 equivalent of [Ph3C][B(C6F5)4] in arene solvents afforded the arene-coordinated uranium alkyl cations, [(XA2)U(CH2SiMe3)(hn-arene)][B(C6F5)4] {arene = benzene (2), toluene (3), bromobenzene (4) and fluorobenzene (5)}. Compounds 2, 3, and 5 were crystallographically characterized, and in all cases the arene is π-coordinated. Solution NMR studies of 2-5 suggest that the binding preferences of the [(XA2)U(CH2SiMe3)]+ cation follow the order: toluene ≈ benzene > bromobenzene > fluorobenzene. Compounds 2-4 generated in C6H5R (R = H, Me or Br, respectively) showed no polymerization activity under 1 atm of ethylene. By contrast, 5 and 5-Th (the thorium analogue of 5) in fluorobenzene at 20 and 70 °C achieved ethylene polymerization activities between 16 800 and 139 200 g mol-1 h-1 atm-1, highlighting the extent to which common arene solvents such as toluene can suppress ethylene polymerization activity in sterically open f-element complexes. However, activation of [(XA2) An(CH2SiMe3)2] {M = U (1) or Th (1-Th)} with [Ph3C][B(C6F5)4] in n-alkane solvents did not afford an active polymerization catalyst due to catalyst decomposition, illustrating the critical role of PhX (X = H, Me, Br or F) coordination for alkyl cation stabilization. Gas phase DFT calculations, including fragment interaction calculations with energy decomposition and ETS-NOCV analysis, were carried out on the cationic portion of 2'-Th, 2', 3' and 5' (analogues of 2-Th, 2, 3 and 5 with hydrogen atoms in place of ligand backbone methyl and tert-butyl groups), providing insight into the nature of actinide–arene bonding, which decreases in strength in the order 2'-Th > 2' ≈ 3' > 5'.
Published: 2022

27. Inference for a gradually deteriorating system with imperfect maintenance

Author: Kamranfar, Hoda, Fouladirad, Mitra, Balakrishnan, Narayanaswamy, University of Birjand [Iran], Aix Marseille Université (AMU), and McMaster University [Hamilton, Ontario]
Subjects: Statistics and Probability, Modeling and Simulation, [MATH]Mathematics [math]
Published: 2021

28. COVID-19 and interdisciplinary research: What are the needs of researchers on aging?

Author: Parminder Raina, Audrey Patocs, Gésine L. Alders, P.J. White, DesignCORE, Humanities, South East Technological University, Kilkenny Road, Carlow, Ireland, and McMaster Institute for Research on Aging, McMaster University, Hamilton, Ontario, Canada
Subjects: Coronavirus disease 2019 (COVID-19), Process (engineering), media_common.quotation_subject, Stakeholder engagement, Session (web analytics), Education, older people, Management of Technology and Innovation, Sociology, older adults, media_common, research, Scope (project management), business.industry, pandemic, aging, COVID-19, Public relations, designCORE - SETU Carlow, Virtual collaboration, interdisciplinary research, co-design, business, Older people, Diversity (politics)
Abstract: COVID-19 has had an extreme effect on older people. Now more than ever we need collaborative approaches to address complex issues within research on aging. However, the pandemic has dramatically changed the way we conduct, interact, and organize research within interdisciplinary groups. This paper describes a case study of how an interdisciplinary institute for research on aging has managed the process of change during COVID-19 restrictions. A design lead, researcher centered approach was used to understand the needs of researchers as they adapted across 6 months. Firstly, an online survey (n=51) was conducted to understand the scope of change and needs. The survey found broad themes ranging from assistance with finding additional funding to adjusting current research proposals. Following the survey, two Co-Design Sessions were conducted. The first session (n=53) diverged thinking to scope ideas from the survey and actionable themes were created. The second session (n=36) was conducted to converge thinking and focus on solutions based on one of these themes. The results revealed a diversity of ideas addressing the needs of interdisciplinary researchers in aging. These ideas spanned from exploring the capacity to do research remotely and creating virtual collaboration spaces to rethinking stakeholder engagement. Received: 1 July 2021Accepted: 12 October 2021
Published: 2021

29. Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis

Author: Samir Jaber, Shannon M. Fernando, Robert A. Fowler, Daniel Brodie, Pierre Cardinal, Laveena Munshi, Margaret S. Herridge, Laurent Brochard, Eddy Fan, Deborah J. Cook, Andrew J.E. Seely, Behnam Sadeghirad, Alexandre Tran, Arthur S. Slutsky, Niall D. Ferguson, Morten Hylander Møller, Karen E. A. Burns, Arnaud W. Thille, Ewan C. Goligher, Bram Rochwerg, University of Ottawa [Ottawa], McMaster University [Hamilton, Ontario], University of Toronto, St. Michael's Hospital, Mount Sinai Health System, University Health Network, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, Sunnybrook Health Sciences Centre, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), University of Copenhagen = Københavns Universitet (KU), Centre hospitalier universitaire de Poitiers (CHU Poitiers), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ottawa Hospital Research Institute [Ottawa] (OHRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), University of Copenhagen = Københavns Universitet (UCPH), and MORNET, Dominique
Subjects: medicine.medical_specialty, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Critical Care and Intensive Care Medicine, medicine.disease_cause, law.invention, 03 medical and health sciences, Mechanical ventilation, 0302 clinical medicine, Randomized controlled trial, law, Oxygen therapy, Anesthesiology, medicine, Critical care medicine, 030212 general & internal medicine, Extubation failure, Critically ill, business.industry, Incidence (epidemiology), 3. Good health, [SDV] Life Sciences [q-bio], 030228 respiratory system, Meta-analysis, High-flow nasal cannula, Emergency medicine, business, Nasal cannula
Abstract: International audience; Purpose: Systematic review and network meta-analysis to investigate the efficacy of noninvasive respiratory strategies, including noninvasive positive pressure ventilation (NIPPV) and high-flow nasal cannula (HFNC), in reducing extubation failure among critically ill adults.Methods: We searched databases from inception through October 2021 for randomized controlled trials (RCTs) evaluating noninvasive respiratory support therapies (NIPPV, HFNC, conventional oxygen therapy, or a combination of these) following extubation in critically ill adults. Two reviewers performed screening, full text review, and extraction independently. The primary outcome of interest was reintubation. We used GRADE to rate the certainty of our findings.Results: We included 36 RCTs (6806 patients). Compared to conventional oxygen therapy, NIPPV (OR 0.65 [95% CI 0.52-0.82]) and HFNC (OR 0.63 [95% CI 0.45-0.87]) reduced reintubation (both moderate certainty). Sensitivity analyses showed that the magnitude of the effect was highest in patients with increased baseline risk of reintubation. As compared to HFNC, no difference in incidence of reintubation was seen with NIPPV (OR 1.04 [95% CI 0.78-1.38], low certainty). Compared to conventional oxygen therapy, neither NIPPV (OR 0.8 [95% CI 0.61-1.04], moderate certainty) or HFNC (OR 0.9 [95% CI 0.66-1.24], low certainty) reduced short-term mortality. Consistent findings were demonstrated across multiple subgroups, including high- and low-risk patients. These results were replicated when evaluating noninvasive strategies for prevention (prophylaxis), but not in rescue (application only after evidence of deterioration) situations.Conclusions: Our findings suggest that both NIPPV and HFNC reduced reintubation in critically ill adults, compared to conventional oxygen therapy. NIPPV did not reduce incidence of reintubation when compared to HFNC. These findings support the preventative application of noninvasive respiratory support strategies to mitigate extubation failure in critically ill adults, but not in rescue conditions.
Published: 2021

30. Improved Gulf Stream separation through Brinkman penalization

Author: L. Debreu, N.K.-R. Kevlahan, P. Marchesiello, Mathematics and computing applied to oceanic and atmospheric flows (AIRSEA), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université Grenoble Alpes (UGA)-Laboratoire Jean Kuntzmann (LJK), Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Department of Mathematics and Statistics [Hamilton], McMaster University [Hamilton, Ontario], Institut de Recherche pour le Développement (IRD), and NKRK was funded by an NSERC Discovery Grant.
Subjects: [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Atmospheric Science, penalization, Gulf Stream, Computer Science (miscellaneous), bathymetry, ocean modeling, Geotechnical Engineering and Engineering Geology, Oceanography, algorithms, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation
Abstract: International audience; The advantage of a smooth representation of bathymetry in terrain-following σ-coordinate ocean models is compromised by the need to avoid numerical errors on steep slopes associated with pressure gradient discretization or spurious diapycnal diffusion. Geopotential z-coordinate models avoid these errors, but greatly underrepresent the interaction of flow with a topographic slope, especially when the bathymetry is underresolved. Hybrid coordinate models are also deficient because it is difficult to find a satisfactory compromise between z and σ coordinates. With volume penalization, we do not seek a compromise, but rather a correction to the usual coordinate systems that realistically recovers continuous and steep bathymetry. The Brinkman volume penalization method studied here is a modified version of the one introduced in Debreu et al. (2020) that simplifies the numerical implementation of the penalization, increases robustness and improves its computational performance for realistic long-term simulations, while preserving accuracy. We apply this penalization method to the Gulf Stream separation problem that has puzzled modelers for decades. The method improves the representation of the flow-topography interaction and achieves realistic separation of the Gulf Stream at resolutions as coarse as 1/8◦. In addition, it provides a tool to separate the effect of eddy activity and topographic slope when changing grid resolution. This has never before been possible because at coarse resolution none of the usual coordinate systems can properly represent a steep continental slope. Our results show that realistic bathymetry is more important than eddy activity in ensuring realistic Gulf Stream separation, even though many recent studies tend to focus on the eddy activity. A steep slope can exert a stabilizing influence that promotes a strong mean slope current with strong inertia that helps it separate from the coast at the topographic curvature of Cape Hatteras. We anticipate that a successful topographic slope correction will be very valuable to climate models, as their current resolution is far from sufficient to represent western boundary currents (WBCs) using traditional coordinate systems. Our results suggest that a climate model with a 1/4◦resolution using volume penalization — and perhaps also some parameterization of the eddy-mean flow interaction to energize the WBCs — would represent ocean circulation much more realistically.
Published: 2022

31. Management of anaphylaxis due to COVID-19 vaccines in the elderly

Author: Paulo Augusto Moreira Camargos, Radolslaw Gawlik, Mirko Petrovic, Gunter J. Sturm, Kristof Nekam, Sergio Bonini, Zhanat Ispayeva, Marilyn Urrutia Pereira, Jean Bousquet, Antti Lauerma, Menachem Rottem, Arzu Yorgancioglu, Hubert Blain, Antonio Cherubini, Mário Morais-Almeida, Nathalie Salles, Charlotte G. Mortz, Sylwia Smolinska, Davor Plavec, A. Bedbrook, Torsten Zuberbier, Helga Kraxner, M. Beatrice Bilò, Sinthia Bosnic-Anticevich, Gaëtan Gavazzi, Finbarr C. Martin, Alvaro A. Cruz, K. S. Bennoor, Isabella Annesi-Maesano, Mohamed H. Shamji, Karin Hoffmann-Sommergruber, Marina Atanaskovic-Markovic, Carsten Bindslev-Jensen, Lan Tt Le, Isabel Skypala, Ana Todo-Bom, Vincenzo Patella, Lorenzo Cecchi, Charlotte Suppli Ulrik, Oscar Palomares, Joaquin Sastre, Hans Jürgen Hoffmann, Knut Brockow, Eva Untersmayr, Martin Hrubisko, Bernadette Eberlein, Aziz Sheikh, Milan Sova, Osman M. Yusuf, Violeta Kvedariene, G. Walter Canonica, Dana Wallace, Ioana Agache, Milena Sokolowska, Jos M. G. A. Schols, Susan Waserman, Stéphanie Miot, Carla Irani, Regina E Roller-Winsberger, Michael Levin, Yves Rolland, Emma Montella, Bilun Gemicioglu, Bolesław Samoliński, Stefano Del Giacco, Madda lenaIllario, Yehia El-Gamal, Olga Lourenço, Jean-Christoph Roger J-P Caubet, Luisa Brussino, Marysia Recto, De Yun Wang, Igor Kaidashev, Renaud Louis, Antonino Romano, Mario E. Zernotti, Jacques Reynes, Pedro Carreiro-Martins, Alexandra F. Santos, Marek Niedoszytko, M. Gotua, Musa Khaitov, Thomas B. Casale, Andrea Matucci, Bernardo Sousa-Pinto, Rafael Stelmach, Dejan Dokic, Joana Vitte, Motohiro Ebisawa, Maria Teresa Ventura, Joaquim Mullol, Tomas Chivato, Petr Panzner, Oliver Pfaar, Sanna Toppila-Salmi, Ioanna Tsiligianni, Wytske Fokkens, Alessandra Vultaggio, H. Neffen, Juan Carlos Ivancevich, Ya-dong Gao, Anna Sediva, Maja Hofmann, Ana Maria Carriazo, João Fonseca, Marek Jutel, A. Benetos, Nhân Pham-Thi, Mona Al-Ahmad, Arunas Valiulis, Mihaela Zidarn, Elizabeth Angier, Yoshitaka Okamoto, Montserrat Fernandez-Rivas, Cezmi A. Akdis, Philip W. Rouadi, Olivier Guérin, John Farrell, Mikaela Odemyr, George Christoff, Vera Mahler, Claus Bachert, Edward F. Knol, Wienczyslawa Czarlewski, Robyn E O'Hehir, Victoria Cardona, Ludger Klimek, Tari Haahtela, Vincent Le Moing, Branislava Milenkovic, Carmen Rondon, Kaja Julge, Jolanta Walusiak-Skorupa, Nikolaos G. Papadopoulos, Aslı Gelincik, Markus Ollert, Piotr Kuna, Leyla Namazova-Baranova, Margitta Worm, Annick Barbaud, Elena Camelia Berghea, Todor A. Popov, Derek K. Chu, María José Torres, Faradiba Sarquis Serpa, Nicola Scichilone, Amir Hamzah Abdul Latiff, Frederico S. Regateiro, Gianni Passalacqua, Humboldt-Universität zu Berlin, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Center for Rhinology and Allergology Wiesbaden, University Hospital Mannheim, Humboldt University Of Berlin, Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Transylvania University, Wrocław Medical University, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Cagliari, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Università Politecnica delle Marche [Ancona] (UNIVPM), Medical Consulting Czarlewski, Universiti Putra Malaysia, University of Southampton, Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), University of Belgrade [Belgrade], Ghent University Hospital, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Dhaka Shishu Hospital [Bangladesh], University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Odense University Hospital (OUH), Italian National Research Council, National Research Council [Italy] (CNR), The University of Sydney, Technische Universität München = Technical University of Munich (TUM), Università degli studi di Torino = University of Turin (UNITO), Universidade Federal de Minas Gerais = Federal University of Minas Gerais [Belo Horizonte, Brazil] (UFMG), IRCCS Research Hospital, Milan, Vall d'Hebron University Hospital [Barcelona], Centro Hospitalar de Lisboa Central E.P.E, University of South Florida [Tampa] (USF), Geneva University Hospital (HUG), Azienda Usl Toscana centro [Firenze], Софийски университет = Sofia University, McMaster University [Hamilton, Ontario], State University of Bahia, Institute of Public Health of Republic of North Macedonia [Skopje], Ain Shams University (ASU), Sagamihara National Hospital [Kanagawa, Japan], Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Amsterdam UMC - Amsterdam University Medical Center, Universidade do Porto = University of Porto, Wuhan University [China], CHU Grenoble, Silesian University of Medicine, Istanbul Faculty of Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Centre Hospitalier Universitaire de Nice (CHU Nice), Helsinki University Hospital [Helsinki, Finlande], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Medizinische Universität Wien = Medical University of Vienna, Aarhus University [Aarhus], Oncology Institute of St Elisabeth, University of Naples Federico II = Università degli studi di Napoli Federico II, St Joseph University, Hôtel-Dieu de France (HDF), Université Saint-Joseph de Beyrouth (USJ), Kazakh National Medical University, Servicio de Alergia e ImmunologiaBuenos Aires (Clinica Santa Isabel), Tartu University Institute of Clinical Medicine, Ukrainina Medical Stomatological Academy [Poltava, Ukraine], Federal Medicobiological Agency [Moscow, Russian Federation], University Medical Center [Utrecht], Semmelweis University [Budapest], Medical University of Łódź (MUL), Vilnius University [Vilnius], University of Medicine and Pharmacy (VIETNAM), University of Cape Town, CHU Sart Tilman, Université de Liège, University of Beira Interior [Portugal] (UBI), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), uBibliorum, Ear, Nose and Throat, AII - Inflammatory diseases, CHU Montpellier, Wroclaw Medical University [Wrocław, Pologne], University of Bari Aldo Moro (UNIBA), Service de Médecine Interne = Hôpital de jour de médecine [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sagamihara National Hospital, Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), CHU Toulouse [Toulouse], RS: CAPHRI - R1 - Ageing and Long-Term Care, Health Services Research, Bousquet J., Agache I., Blain H., Jutel M., Ventura M.T., Worm M., Del Giacco S., Benetos A., Bilo B.M., Czarlewski W., Abdul Latiff A.H., Al-Ahmad M., Angier E., Annesi-Maesano I., Atanaskovic-Markovic M., Bachert C., Barbaud A., Bedbrook A., Bennoor K.S., Berghea E.C., Bindslev-Jensen C., Bonini S., Bosnic-Anticevich S., Brockow K., Brussino L., Camargos P., Canonica G.W., Cardona V., Carreiro-Martins P., Carriazo A., Casale T., Caubet J.-C., Cecchi L., Cherubini A., Christoff G., Chu D.K., Cruz A.A., Dokic D., El-Gamal Y., Ebisawa M., Eberlein B., Farrell J., Fernandez-Rivas M., Fokkens W.J., Fonseca J.A., Gao Y., Gavazzi G., Gawlik R., Gelincik A., Gemicioglu B., Gotua M., Guerin O., Haahtela T., Hoffmann-Sommergruber K., Hoffmann H.J., Hofmann M., Hrubisko M., Illario M., Irani C., Ispayeva Z., Ivancevich J.C., Julge K., Kaidashev I., Khaitov M., Knol E., Kraxner H., Kuna P., Kvedariene V., Lauerma A., Le L.T.T., Le Moing V., Levin M., Louis R., Lourenco O., Mahler V., Martin F.C., Matucci A., Milenkovic B., Miot S., Montella E., Morais-Almeida M., Mortz C.G., Mullol J., Namazova-Baranova L., Neffen H., Nekam K., Niedoszytko M., Odemyr M., O'Hehir R.E., Okamoto Y., Ollert M., Palomares O., Papadopoulos N.G., Panzner P., Passalacqua G., Patella V., Petrovic M., Pfaar O., Pham-Thi N., Plavec D., Popov T.A., Recto M.T., Regateiro F.S., Reynes J., Roller-Winsberger R.E., Rolland Y., Romano A., Rondon C., Rottem M., Rouadi P.W., Salles N., Samolinski B., Santos A.F., S Sarquis F., Sastre J., M. G. A. Schols J., Scichilone N., Sediva A., Shamji M.H., Sheikh A., Skypala I., Smolinska S., Sokolowska M., Sousa-Pinto B., Sova M., Stelmach R., Sturm G., Suppli Ulrik C., Todo-Bom A.M., Toppila-Salmi S., Tsiligianni I., Torres M., Untersmayr E., Urrutia Pereira M., Valiulis A., Vitte J., Vultaggio A., Wallace D., Walusiak-Skorupa J., Wang D.-Y., Waserman S., Yorgancioglu A., Yusuf O.M., Zernotti M., Zidarn M., Chivato T., Akdis C.A., Zuberbier T., Klimek L., HUS Inflammation Center, University of Helsinki, and Department of Dermatology, Allergology and Venereology
Subjects: Male, Allergy, Pediatrics, Eaaci Position Paper, COVID-19 vaccines, older (adults, GUIDELINES, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine and Health Sciences, Immunology and Allergy, Medicine, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Geriatrics, MESH: Aged, RISK, Vaccines, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, people), EPINEPHRINE, Epinephrine, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, COVID -19 vaccines, Anaphylaxis, medicine.drug, older (adults/people), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), MESH: Covid-19, MESH: Epinephrine, Immunology, adrenaline, anaphylaxis, Aged, COVID-19 Vaccines, Humans, SARS-CoV-2, COVID-19, Settore MED/10 - Malattie Dell'Apparato Respiratorio, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Diabetes mellitus, Anaphylaxis/etiology, MESH: SARS-CoV-2, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, COVID‐19 vaccines, Older - Adults/people, Asthma, MESH: Humans, business.industry, adrenaline, anaphylaxis, COVID-19 vaccines, older (adults/people), medicine.disease, Obesity, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, MESH: Male, MESH: Anaphylaxis, Older, 3121 General medicine, internal medicine and other clinical medicine, business, MESH: Covid-19 vaccines, 030215 immunology
Abstract: Submitted by (omml@ubi.pt) on 2021-07-05T10:47:24Z No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Approved for entry into archive by Pessoa (pfep@ubi.pt) on 2021-07-05T10:49:11Z (GMT) No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Rejected by Pessoa (pfep@ubi.pt), reason: Rever os nomes dos autores. Depois da correção é só voltar a submeter. on 2021-07-05T10:54:19Z (GMT) Submitted by (omml@ubi.pt) on 2021-07-05T11:52:24Z No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Approved for entry into archive by Pessoa (pfep@ubi.pt) on 2021-07-05T13:34:51Z (GMT) No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Approved for entry into archive by Pessoa (pfep@ubi.pt) on 2021-07-05T13:35:49Z (GMT) No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Made available in DSpace on 2021-07-05T13:35:49Z (GMT). No. of bitstreams: 1 2021_Bousquet J_A_COVID anaphylaxis.pdf: 12561118 bytes, checksum: 2f801ee76ad2cb3cbdaa02ffabea8e09 (MD5) Previous issue date: 2021-04-02 info:eu-repo/semantics/publishedVersion
Published: 2021

32. Parameter Optimization for an Underwater Optical Wireless Vertical Link Subject to Link Misalignments

Author: Ikenna Chinazaekpere Ijeh, Steve Hranilovic, Mohammad-Ali Khalighi, Institut FRESNEL (FRESNEL), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Department of Computing and Software (McMaster University), McMaster University [Hamilton, Ontario], and Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Computer science, business.industry, Mechanical Engineering, Attenuation, Monte Carlo method, Ocean Engineering, Vertical underwater links, Silicon photomultiplier, Link misalignment, Parameter optimization, Control theory, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, Optical wireless, Wireless, Sensitivity (control systems), Electrical and Electronic Engineering, Performance improvement, Adaptive optics, business, Underwater wireless optical communications, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Communication channel
Abstract: International audience; We consider transmitter-receiver (Tx-Rx) parameter optimization for a vertical underwater wireless optical communication link under misalignment conditions. The Tx is assumed to use a light-emitting diode while the Rx uses a silicon photomultiplier that allows a high Rx sensitivity. We consider two typical application scenarios and investigate optimization of the Tx and the Rx parameters to optimize the link performance in terms of outage probability. We derive accurate analytical expressions for the distribution of the channel attenuation accounting for link misalignments, which allows for the evaluation of the link performance in terms of bit-error-rate and outage probability without resorting to costly Monte Carlo simulations. Through numerical results, we show and discuss the impact of parameter optimization on the link performance in different link configurations and for various misalignment conditions. In particular, the presented results show the significant performance improvement resulting from optimizing the Tx beam divergence and the Rx FoV in the presence of pointing errors.
Published: 2021

33. Nosocomial cluster of carbapenemase-producing Enterobacter cloacae in an intensive care unit dedicated COVID-19

Author: Olivier Belmonte, Patrick Mavingui, Jérôme Allyn, Thomas Garrigos, Pascal Cholley, Xavier Bertrand, Guillaume Miltgen, Nicolas Allou, Didier Hocquet, Marine Deleume, Nathalie Lugagne, David A. Wilkinson, Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Processus Infectieux en Milieu Insulaire Tropical (PIMIT), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IRD-Centre National de la Recherche Scientifique (CNRS), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Département d'Informatique Clinique [Saint-Denis, La Réunion], Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion], McMaster University [Hamilton, Ontario], Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)
Subjects: Microbiology (medical), medicine.medical_specialty, Short Report, Context (language use), Infectious and parasitic diseases, RC109-216, Disease cluster, beta-Lactamases, Disease Outbreaks, law.invention, Carbapenemase, Medical microbiology, Bacterial Proteins, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, law, Intensive care, Personal protective equipment, Enterobacter cloacae, medicine, Humans, Infection control, Pharmacology (medical), Intensive care unit, Intensive care medicine, Cross Infection, Infection Control, biology, Coinfection, SARS-CoV-2, business.industry, Enterobacteriaceae Infections, Public Health, Environmental and Occupational Health, COVID-19, biology.organism_classification, Intensive Care Units, Carbapenem-Resistant Enterobacteriaceae, Infectious Diseases, Cross transmission, business
Abstract: Concomitant prevention of SARS-CoV-2 and extensively drug-resistant bacteria transmission is a difficult challenge in intensive care units dedicated to COVID-19 patients. We report a nosocomial cluster of four patients carrying NDM-1 plasmid-encoded carbapenemase-producing Enterobacter cloacae. Two main factors may have contributed to cross-transmission: misuse of gloves and absence of change of personal protective equipment, in the context of COVID-19-associated shortage. This work highlights the importance of maintaining infection control measures to prevent CPE cross-transmission despite the difficult context and that this type of outbreak can potentially involve several species of Enterobacterales. Supplementary Information The online version contains supplementary material available at 10.1186/s13756-021-01022-6.
Published: 2021

34. A stable isotope toolbox for water and inorganic carbon cycle studies

Author: Sergey Assonov, Claude Hillaire-Marcel, Sang-Tae Kim, Christophe Lécuyer, Prosenjit Ghosh, Harro A. J. Meijer, Marc Blanchard, Hans Christian Steen-Larsen, Amaelle Landais, Centre de recherche sur la dynamique du système Terre (GEOTOP), École Polytechnique de Montréal (EPM)-McGill University = Université McGill [Montréal, Canada]-Université de Montréal (UdeM)-Université du Québec en Abitibi-Témiscamingue (UQAT)-Université du Québec à Rimouski (UQAR)-Concordia University [Montreal]-Université du Québec à Montréal = University of Québec in Montréal (UQAM), McMaster University [Hamilton, Ontario], Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Glaces et Continents, Climats et Isotopes Stables (GLACCIOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Indian Institute of Science [Bangalore] (IISc Bangalore), International Atomic Energy Agency [Vienna] (IAEA), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Géosciences Environnement Toulouse (GET), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Centre for Isotope Research [Groningen] (CIO), University of Groningen [Groningen], Bjerknes Centre for Climate Research (BCCR), Department of Biological Sciences [Bergen] (BIO / UiB), University of Bergen (UiB)-University of Bergen (UiB), Université de Montréal (UdeM)-McGill University = Université McGill [Montréal, Canada]-École Polytechnique de Montréal (EPM)-Concordia University [Montreal]-Université du Québec à Rimouski (UQAR)-Université du Québec à Montréal = University of Québec in Montréal (UQAM)-Université du Québec en Abitibi-Témiscamingue (UQAT), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement [Lyon] (LGL-TPE), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), and Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)
Subjects: Atmospheric Science, 010504 meteorology & atmospheric sciences, Earth science, chemistry.chemical_element, 01 natural sciences, Isotopes of oxygen, Carbon cycle, chemistry.chemical_compound, Total inorganic carbon, Water cycle, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Nature and Landscape Conservation, Earth-Surface Processes, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Isotope, Stable isotope ratio, 010401 analytical chemistry, Pollution, 0104 chemical sciences, chemistry, 13. Climate action, Environmental science, Carbonate, Carbon
Abstract: Stable isotopes of hydrogen, carbon and oxygen are used to investigate numerous physical and chemical processes in the water and inorganic carbon cycles. Measuring and comparing natural isotopic variations requires reliable primary reference materials and consistent data treatment. However, these reference materials have changed over time, while advances in technology have led to better constrained isotopic compositions of the reference materials. In this Technical Review, we provide an overview of the historical evolution of such materials, and explain their relationships across time and isotopic scales. Recommendations are provided for the measurement and reporting of isotopic compositions against the consensual VPDB and VSMOW scales in light of the newest carbonate and water reference materials distributed by the International Atomic Energy Agency. Stable isotope fractionation factors and their temperature dependence in processes specific to the water cycle (2H, 18O, 17O) and the CO2–water–carbonate system (13C, 18O) are described, including for carbonate clumped isotope thermometry. Propagation of errors is also addressed for a consistent reporting of real uncertainties of isotopic measurements and calculations. Lastly, current gaps in knowledge on the behaviour of stable isotopes in the water cycle and the CO2–water–carbonate system are highlighted for future studies. The use of isotopes has provided key insights into the Earth system, but their use can be fraught with experimental and theoretical pitfalls. This Technical Review explains the use of and fractionation factors associated with hydrogen, carbon and oxygen isotopes in water cycle and CO2–carbonate–water system studies.
Published: 2021

35. Detection of Direct Oral Anticoagulants in Patient Urine Samples by Prototype and Commercial Test Strips for DOACs - A Systematic Review and Meta-analysis

Author: Job Harenberg, Jonathan Douxfils, Ismail Elalamy, Rupert Bauersachs, Svetlana Hetjens, Mark Crowther, Jan Beyer‐Westendorf, Andrea Martini, Christel Weiss, Heidelberg University, Klinikum Darmstadt (RMB), Klinikum Darmstadt, University Hospital Carl Gustav Carus [Dresden, Germany], Technische Universität Dresden = Dresden University of Technology (TU Dresden), McMaster University [Hamilton, Ontario], Université de Namur [Namur] (UNamur), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service d'Hématologie biologique [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sechenov First Moscow State Medical University, HAL-SU, Gestionnaire, Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Subjects: medicine.medical_specialty, Point-of-care testing, Urine, 030204 cardiovascular system & hematology, Cochrane Library, direct oral anticoagulants, Test strips, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diseases of the circulatory (Cardiovascular) system, Medicine, In patient, 030212 general & internal medicine, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, business.industry, Dipstick, Odds ratio, 6. Clean water, 3. Good health, meta-analysis, DOAC Dipstick, RC666-701, Meta-analysis, Original Article, point-of-care test, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: The DOAC Dipstick accurately detects the presence or absence of factor Xa (DXI) and thrombin inhibitor (DTI) classes of direct oral anticoagulants (DOACs) in patients' urine samples on DOAC treatment. The aim of the study was to systematically review the literature and compare the performance of prototype and commercial test strips with a meta-analysis.A systematic literature search of electronic databases PubMed (MEDLINE) and Cochrane Library was performed. Heterogeneity between studies was calculated using the Chi-squared test and the I2 index. A random effects model was used to pool data to compare the performance of prototype and commercial test strips.Using PRISMA reporting guidelines, four of 1,081 publications were eligible for inclusion in the meta-analysis: three reporting on prototype (DXI n = 658, DTI n = 586) and one on commercial test strips (DXI n = 451, DTI n = 429). Sensitivity and specificity of DXI and DTI detection did not differ significantly between the prototype and commercial test strips. Odds ratios were 0.718 and 0.365 for sensitivity and 1.211 and 1.072 for specificity of DXI and DTI (p-values between 0.3334 and 1.000), respectively. The pooled sensitivity and specificity values for DXI were 0.968 (p = 0.1290, I2 47.1%) and 0.979 (p = 0.1965, I2 35.9%), and for DTI 0.993 (p = 0.1870, I2 37.5%) and 0.993 (p = 0.7380, I2 0%), respectively.Prototype and commercial DOAC test strips did not differ in their ability to detect DXI and DTI in patient urine samples. This supports the confidence in use of the DOAC Dipstick test, although it needs to be validated in specific patient populations.
Published: 2021

36. Assessment of Phase Transformations in Binary Fe–Mn Alloys: Effects of Composition and of Plastic Strain

Author: Artem Arlazarov, Hatem S. Zurob, R. Young, J. Fuller-Thomson, Olivier Bouaziz, McMaster University [Hamilton, Ontario], ArcelorMittal, Laboratoire d'Etude des Microstructures et de Mécanique des Matériaux (LEM3), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), Labex DAMAS, Université de Lorraine (UL), ANR-11-LABX-0008,DAMAS,Design des Alliages Métalliques pour Allègement des Structures(2011), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Sciences et Technologies
Subjects: Materials science, Alloy, chemistry.chemical_element, Thermodynamics, 02 engineering and technology, Manganese, engineering.material, Plasticity, ε-Martensite, SFE, Strain, [SPI]Engineering Sciences [physics], Phase (matter), Materials Chemistry, ComputingMilieux_MISCELLANEOUS, α′-Martensite, Austenite, Strain (chemistry), 020502 materials, Metals and Alloys, Phase transformation, Condensed Matter Physics, Microstructure, 0205 materials engineering, chemistry, Mechanics of Materials, Martensite, engineering
Abstract: International audience; A simple, first order description of the formation of ε- and α′-martensite in meta-stable austenitic Fe–Mn alloys containing 12–35 wt% Mn was developed. Given the initial volume fractions of ε- and α′-martensite in the non-deformed material, it is possible to calculate the evolution of phase fractions as a function of applied strain. An accurate estimate of the initial amounts of ε- and α′-martensite based solely on the Mn content of the alloy, could not be obtained due to the important role of microstructure features and processing conditions on the martensitic transformations.
Published: 2021

37. Child and adolescent diet in Late Roman Gaul: An investigation of incremental dietary stable isotopes in tooth dentine

Author: Sheri Findlay, Tracy L. Prowse, Cécile Chapelain de Seréville-Niel, L. Creighton Avery, Megan Brickley, McMaster University [Hamilton, Ontario], Department of Anthropology, Department of Pediatrics, Division of Adolescent Medicine. McMaster University, Centre Michel de Boüard - Centre de recherches archéologiques et historiques anciennes et médiévales (CRAHAM), Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Archeology, [SHS.SOCIO]Humanities and Social Sciences/Sociology, 060101 anthropology, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, 060102 archaeology, Stable isotope ratio, [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, 06 humanities and the arts, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, Biology, Ancient history, [SHS]Humanities and Social Sciences, Roman Empire, Child and adolescent, Anthropology, 0601 history and archaeology, [SHS.HIST]Humanities and Social Sciences/History, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2021

38. Global Decision Making Over Deep Variability in Feedback-Driven Software Development

Author: Joerg Kienzle, Benoit Combemale, Gunter Mussbacher, Omar Alam, Francis Bordeleau, Lola Burgueno, Gregor Engels, Jessie Galasso, Jean-Marc Jézéquel, Bettina Kemme, Sébastien Mosser, Houari Sahraoui, Maximilian Schiedermeier, Eugene Syriani, McGill University = Université McGill [Montréal, Canada], Diversity-centric Software Engineering (DiverSe), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-LANGAGE ET GÉNIE LOGICIEL (IRISA-D4), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Smart Modeling for softw@re Research and Technology (IRIT-SM@RT), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Trent University, Ecole de Technologie Supérieure [Montréal] (ETS), Open University of Catalonia [Barcelona], University of Paderborn, Université de Montréal (UdeM), and McMaster University [Hamilton, Ontario]
Subjects: Feedback Loo, [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE], MODA, Iterative Software Development
Abstract: International audience; To succeed with the development of modern software, organizations must have the agility to adapt faster to constantly evolving environments to deliver more reliable and optimized solutions that can be adapted to the needs and environments of their stakeholders including users, customers, business, development, and IT. However, stakeholders do not have sufficient automated support for global decision making, considering the increasing variability of the solution space, the frequent lack of explicit representation of its associated variability and decision points, and the uncertainty of the impact of decisions on stakeholders and the solution space. This leads to an ad-hoc decision making process that is slow, error-prone, and often favors local knowledge over global, organization-wide objectives. The Multi-Plane Models and Data (MP-MODA) framework explicitly represents and manages variability, impacts, and decision points. It enables automation and tool support in aid of a multi-criteria decision making process involving different stakeholders within a feedback-driven software development process where feedback cycles aim to reduce uncertainty. We present the conceptual structure of the framework, discuss its potential benefits, and enumerate key challenges related to tool supported automation and analysis within MP-MODA.
Published: 2022

39. Efficacy and Safety of Intravitreal Aflibercept Treat-and-Extend for Macular Edema in Central Retinal Vein Occlusion: the CENTERA Study

Author: Varun Chaudhary, Nicole Eter, Michael Larsen, Thomas Schmelter, Helmut Allmeier, Jean-François Korobelnik, Clare Bailey, Sebastian Wolf, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], University of Copenhagen = Københavns Universitet (KU), University of Münster, Universität Bern [Bern], and McMaster University [Hamilton, Ontario]
Subjects: Adult, Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, Adolescent, Recombinant Fusion Proteins, Visual Acuity, Angiogenesis Inhibitors, 610 Medicine & health, Treat and extend, Macular Edema, law.invention, 03 medical and health sciences, 0302 clinical medicine, Central retinal vein occlusion, Randomized controlled trial, law, Ophthalmology, Retinal Vein Occlusion, medicine, Humans, In patient, Dosing, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, Macular edema, Aged, 030304 developmental biology, Aflibercept, Aged, 80 and over, 0303 health sciences, business.industry, Middle Aged, medicine.disease, Clinical trial, Receptors, Vascular Endothelial Growth Factor, Treatment Outcome, Intravitreal Injections, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, 030221 ophthalmology & optometry, Female, business, Tomography, Optical Coherence, medicine.drug
Abstract: To evaluate the efficacy and safety of intravitreal aflibercept (IVT-AFL) treat-and-extend dosing in patients with macular edema secondary to central retinal vein occlusion (CRVO).CENTERA (Evaluation of a Treat and Extend Regimen of Intravitreal Aflibercept for Macular Edema Secondary to CRVO; NCT02800642) was an open-label, Phase 4 clinical study.Patients received 2 mg of IVT-AFL at baseline and every 4 weeks thereafter, until disease stability criteria were met (or until week 20), at which point treatment intervals were adjusted in 2-week increments based on functional and anatomic outcomes.From baseline to week 76, 105 patients (65.6%) (P.0001 [test against threshold of 40%]) gained ≥15 letters; and, during the treat-and-extend phase, 72 patients (45.0%) (P = 0.8822 [test against threshold of 50%]) achieved a mean treatment interval of ≥8 weeks. A last and next planned treatment interval of ≥8 weeks was achieved by 101 patients (63.1%) and by 108 patients (67.5%), respectively. Mean ± SD best-corrected visual acuity increased from 51.9 ± 16.8 letters at baseline to 72.3 ± 18.5 letters at week 76 (mean change: +20.3 ± 19.5 letters), and central retinal thickness decreased from 759.9 ± 246.0 µm at baseline to 265.4 ± 57.9 µm at week 76 (mean change: -496.1 ± 252.4 µm). The safety profile of IVT-AFL was consistent with that of previous studies.Clinically meaningful improvements in functional and anatomic outcomes were achieved with IVT-AFL treat-and-extend dosing. Most patients achieved a last actual and last intended treatment interval of ≥8 weeks; therefore, treatment intervals may have been extended even further with a longer study duration.
Published: 2021

40. Influencing Parameters on Discharge Bearing Currents in Inverter-Fed Induction Motors

Author: Cyrille Caironi, Thierry Boileau, Babak Nahid-Mobarakeh, Thibaud Plazenet, Laboratoire Énergies et Mécanique Théorique et Appliquée (LEMTA ), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Caircy, and McMaster University [Hamilton, Ontario]
Subjects: Electric motor, Bearing (mechanical), [SPI.NRJ]Engineering Sciences [physics]/Electric power, 020208 electrical & electronic engineering, Energy Engineering and Power Technology, 02 engineering and technology, Tribology, Capacitance, Automotive engineering, law.invention, Micro pitting, 020303 mechanical engineering & transports, 0203 mechanical engineering, law, 0202 electrical engineering, electronic engineering, information engineering, Environmental science, Inverter, Electrical and Electronic Engineering, ComputingMilieux_MISCELLANEOUS, Induction motor, Voltage
Abstract: This article investigates discharge bearing currents in inverter-fed electric motors. Industrial reports indicate that among prevalent bearing failures, bearing currents are one of the influent drivers leading to a variety of tribological issues and premature wear in bearings. While the root-causes of bearing currents have been extensively reported over the years, the response of bearing under voltage stress and the factors that influence bearing endangerment through electric discharges have been far less studied. An online measurement of the bearing voltage is proposed on a motor test-bench to estimate both the discharge activity and the energy of the discharges. The designed test bed allows reproduction of representative bearing currents leading to electrical micropitting. This paper presents extensive measurements results that highlight the critical operating conditions and parameters that worsen the discharge phenomenon inside bearings. Testing protocols are performed to quantify the influence of each parameter separately. While the bearing voltage magnitude play a significant role in the discharge phenomenon, other parameters such as successive startups, bearing temperature, and type of grease deserve appropriate investigations to avoid or mitigate the well-known shortened bearing life under inverter operation.
Published: 2021

41. Overview of retrospective data harmonisation in the MINDMAP project

Author: Irina Motoc, Isabel Fortier, Tina W. Wey, Steinar Krokstad, Basile Chaix, Parminder Raina, Dany Doiron, J Mark Noordzij, Frank J. van Lenthe, Martin Bobak, Rita Wissa, Erik J. Timmermans, Milagros Ruiz, Guillaume Fabre, Mariëlle A. Beenackers, Erik R. Sund, Epidemiology and Data Science, Amsterdam Reproduction & Development (AR&D), McGill University Health Center [Montreal] (MUHC), Amsterdam UMC, Erasmus University Medical Center [Rotterdam] (Erasmus MC), University College of London [London] (UCL), Utrecht University [Utrecht], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), McMaster University [Hamilton, Ontario], Gestionnaire, Hal Sorbonne Université, Amsterdam UMC - Amsterdam University Medical Center, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), APH - Mental Health, APH - Aging & Later Life, and Public Health
Subjects: Aging, Process (engineering), Medisinske Fag: 700::Klinisk medisinske fag: 750::Geriatri: 778 [VDP], [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, Retrospective data, 03 medical and health sciences, 0302 clinical medicine, Project management process, SDG 3 - Good Health and Well-being, Humans, Medicine, longitudinal studies, 030212 general & internal medicine, Original Research, Retrospective Studies, Data collection, Descriptive statistics, Matematikk og Naturvitenskap: 400::Informasjons- og kommunikasjonsvitenskap: 420::Databaser og multimediasystemer: 428 [VDP], business.industry, Public Health, Environmental and Occupational Health, methodology, Environmental Exposure, Missing data, Data science, [SDV] Life Sciences [q-bio], Data set, Variable (computer science), Mental Health, Cohort studies, epidemiology, Samfunnsvitenskap: 200::Psykologi: 260 [VDP], business
Abstract: Background The MINDMAP project implemented a multinational data infrastructure to investigate the direct and interactive effects of urban environments and individual determinants of mental well-being and cognitive function in ageing populations. Using a rigorous process involving multiple teams of experts, longitudinal data from six cohort studies were harmonised to serve MINDMAP objectives. This article documents the retrospective data harmonisation process achieved based on the Maelstrom Research approach and provides a descriptive analysis of the harmonised data generated. Methods A list of core variables (the DataSchema) to be generated across cohorts was first defined, and the potential for cohort-specific data sets to generate the DataSchema variables was assessed. Where relevant, algorithms were developed to process cohort-specific data into DataSchema format, and information to be provided to data users was documented. Procedures and harmonisation decisions were thoroughly documented. Results The MINDMAP DataSchema (v2.0, April 2020) comprised a total of 2841 variables (993 on individual determinants and outcomes, 1848 on environmental exposures) distributed across up to seven data collection events. The harmonised data set included 220 621 participants from six cohorts (10 subpopulations). Harmonisation potential, participant distributions and missing values varied across data sets and variable domains. Conclusion The MINDMAP project implemented a collaborative and transparent process to generate a rich integrated data set for research in ageing, mental well-being and the urban environment. The harmonised data set supports a range of research activities and will continue to be updated to serve ongoing and future MINDMAP research needs.
Published: 2021

42. FGF19 is Downregulated in Idiopathic Pulmonary Fibrosis and Inhibits Lung Fibrosis in Mice

Author: Aurélien Justet, Mada Ghanem, Tiara Boghanim, Mouna Hachem, Eirini Vasarmidi, Madeleine Jaillet, Aurélie Vadel, Audrey Joannes, Pierre Mordant, Philippe Bonniaud, Martin Kolb, Lei Ling, Aurélie Cazes, Hervé Mal, Arnaud Mailleux, Bruno Crestani, Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), and McMaster University [Hamilton, Ontario]
Subjects: Pulmonary and Respiratory Medicine, [SDV]Life Sciences [q-bio], Clinical Biochemistry, Cell Biology, Fibroblasts, respiratory system, Idiopathic Pulmonary Fibrosis, respiratory tract diseases, Fibroblast Growth Factors, Bleomycin, Mice, Transforming Growth Factor beta, Animals, Humans, Collagen, Myofibroblasts, Molecular Biology, Lung
Abstract: International audience; IPF is a devastating lung disease with limited therapeutic possibilities. FGF19, an endocrine FGF, was recently shown to decrease liver fibrosis. To ask whether FGF19 had anti-fibrotic properties in the lung and decipher its effects on common features associated with lung fibrogenesis. We assessed, by Elisa, FGF19 levels in plasma and bronchoalveolar lavage fluids (BALF)obtained from controls and IPF patients. In vivo, using an intravenously administered adeno11 associated virus (AAV), we overexpressed FGF19 at the fibrotic phase of two experimental models of murine lung fibrosis and assessed its effect on lung morphology, lung collagen content, fibrosis markers and pro fibrotic mediator expression, at mRNA and protein levels. In vitro, we investigated whether FGF19 could modulate the TGFβ-induced differentiation of primary human lung fibroblast into myofibroblast and the apoptosis of murine alveolar type II cell. While FGF19 was not detected in BALF, FGF19 concentration was decreased in the plasma of IPF patients compared to controls. In vivo, the overexpression of FGF19 was associated with a marked decrease of lung fibrosis and fibrosis markers, with a decrease of pro fibrotic mediator expression and lung collagen content. In vitro, FGF19 decreased alveolar type 2 epithelial cell apoptosis through the decrease of the proapoptotic BIM protein expression and prevented TGF-ß induced myofibroblast differentiation through the inhibition of JNK phosphorylation. Altogether these data identify FGF19 as an anti-fibrotic molecule with a potential therapeutic interest in fibrotic lung disorders.
Published: 2022

43. AGREE-S: AGREE II extension for surgical interventions – United European Gastroenterology and European Association for Endoscopic Surgery methodological guide

Author: Logullo, P, Florez, ID, Antoniou, GA, Markar, S, López‐Cano, M, Silecchia, G, Tsokani, S, Mavridis, D, Brouwers, M, Antoniou, SA, Sami Abdel Dayem Amer, Y, Bertolaccini, L, Alonso‐Coello, P, Akl, EA, Chand, M, Como, JJ, Borst, GJ, Di Saverio, S, Emile, S, Eom, BW, Gorter, R, Hanna, G, Immonen, K, Lai, Q, Lumen, N, Mathew, JL, Montendori, A, Moya, M, Pellino, G, Sanabria, A, Saratzis, A, Smart, N, Stefanidis, D, Zaninotto, G, Paediatric Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D), Pediatric surgery, Patricia, Logullo, Ivan D, Florez, George A, Antoniou, Sheraz, Markar, Manuel, López-Cano, Gianfranco, Silecchia, Sofia, Tsokani, Dimitrios, Mavridi, Melissa, Brouwer, Stavros A, Antoniou, Sami Abdel Dayem Amer, Yasser, Bertolaccini, Luca, Alonso-Coello, Pablo, A Akl, Elie, Chand, Manish, J Como, John, J de Borst, Gert, Di Saverio, Salomone, Emile, Sameh, Wool Eom, Bang, Gorter, Ramon, Hanna, George, Immonen, Kaisa, Lai, Quirino, Lumen, Nicolaa, L Mathew, Joseph, Montendori, Alessandro, Moya, Martin, Pellino, Gianluca, Sanabria, Alvaro, Saratzis, Athanasio, Smart, Neil, Stefanidis, Dimitrio, Zaninotto, Giovanni, Institut Català de la Salut, [Logullo P] Department Nuffield of Orthopaedics, Rheumatology & Musculoskeletal Sciences, UK EQUATOR Centre, Centre for Statistics in Medicine, University of Oxford, Oxford, UK. [Florez ID] Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada. Department of Pediatrics, University of Antioquia, Medellin, Colombia. [Antoniou GA] Department of Vascular and Endovascular Surgery, Manchester University NHS Foundation Trust, Manchester, UK. Division of Cardiovascular Sciences, School of Medical Sciences, The University of Manchester, Manchester, UK. [Markar S] Nuffield Department of Surgery, University of Oxford, Oxford, Oxfordshire, UK. Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden. [López-Cano M] Unitat de Cirurgia de la Paret Abdominal, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Silecchia G] Department of Medico‐Surgical Sciences and Translation Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy, and Vall d'Hebron Barcelona Hospital Campus
Subjects: Surgical Procedures, Operative [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], evidence, gastroenterology, factor analysis, methodology, intervenciones quirúrgicas [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], agree ii, agree-s, guidelines, quality, endoscopy, factor analysis, statistical, humans, Oncology, Operacions quirúrgiques, Factor Analysis, Statistical, Gastroenterologia, Health Occupations::Medicine::Internal Medicine::Gastroenterology [DISCIPLINES AND OCCUPATIONS], guideline, statistical, profesiones sanitarias::medicina::medicina interna::gastroenterología [DISCIPLINAS Y OCUPACIONES], Human
Abstract: Evidence; Guidelines; Quality Evidencia; Pautas; Calidad Evidència; Pautes; Qualitat Background The Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument has been developed to inform the methodology, reporting and appraisal of clinical practice guidelines. Evidence suggests that the quality of surgical guidelines can be improved, and the structure and content of AGREE II can be modified to help enhance the quality of guidelines of surgical interventions. Objective To develop an extension of AGREE II specifically designed for guidelines of surgical interventions. Methods In the tripartite Guideline Assessment Project (GAP) funded by United European Gastroenterology and the European Association for Endoscopic Surgery, (i) we assessed the quality of surgical guidelines and we identified factors associated with higher quality (GAP I); (ii) we applied correlation analysis, factor analysis and the item response theory to inform an adaption of AGREE II for the purposes of surgical guidelines (GAP II); and (iii) we developed an AGREE II extension for surgical interventions, informed by the results of GAP I, GAP II, and a Delphi process of stakeholders, including representation from interventional and surgical disciplines; the Guideline International Network (GIN); the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group; the Enhancing the QUAlity and Transparency Of health Research (EQUATOR) initiative; and representation of surgical journal editors and patient/public. Results We developed AGREE-S, an AGREE II extension for surgical interventions, which comprises 24 items organized in 6 domains; Scope and purpose, Stakeholders, Evidence synthesis, Development of recommendations, Editorial independence, and Implementation and update. The panel of stakeholders proposed 3 additional items: development of a guideline protocol, consideration of practice variability and surgical/interventional expertise in different settings, and specification of infrastructures required to implement the recommendations. Three of the existing items were amended, 7 items were rearranged among the domains, and one item was removed. The domain Rigour of Development was divided into domains on Evidence Synthesis and Development of Recommendations. The new domain Development of Recommendations incorporates items from the original AGREE II domain Clarity of Presentation. Conclusion AGREE-S is an evidence-based and stakeholder-informed extension of the AGREE II instrument, that can be used as a guide for the development and adaption of guidelines on surgical interventions. The Guideline Assessment Project (GAP) III received financial support from the United European Gastroenterology (UEG) and the European Association for Endoscopic Surgery and Other Interventional Techniques (EAES), both non-profit organizations. The funders had no role in the design or development of this project.
Published: 2022

44. Under-Sea Ice Diffusing Optical Communications

Author: Abdallah S. Ghazy, Mohammad-Ali Khalighi, Haitham S. Khallaf, Steve Hranilovic, Department of Computing and Software (McMaster University), McMaster University [Hamilton, Ontario], Institut FRESNEL (FRESNEL), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), and Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: geography, geography.geographical_feature_category, Underwater wireless optical communication, General Computer Science, 020209 energy, General Engineering, Optical communication, 02 engineering and technology, AUVs, TK1-9971, Oceanography, diffusing communication, 0202 electrical engineering, electronic engineering, information engineering, Sea ice, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, channel impulse response, 020201 artificial intelligence & image processing, General Materials Science, Electrical engineering. Electronics. Nuclear engineering, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Geology
Abstract: International audience; In this paper, we propose a novel approach to establish a reliable high-speed broadcast communication link between a group of autonomous underwater vehicles (AUVs) swarm under-sea ice. We utilize the fact that sea ice exists above the AUVs to diffuse the optical beam sent from AUV transmitter. We model this channel using a new seawater-sea ice cascaded layers (SSCL) model in which the vertical channel is divided into multiple layers based on their optical characteristics. The diffusing pattern of the SSCL model is computed using Monte Carlo numerical ray-tracing technique. We derive a quasi-analytic equation for the channel impulse response (CIR) which is valid for AUV receivers with different configurations, locations and orientations. The communication performance of underwater sea ice diffusing system is quantified via bit error rate performance, power penalty and and maximum achievable bit rate. Our results reveal that, for a snow-covered sea ice sheet with thickness of 36 cm and bare sea ice sheet with thickness 12 cm, the proposed system can achieve a broadcast communication rate of 100 Mbps with ranges up to 3.5 meters and 3 meters, respectively, with BER less than 10 −3 and average transmitted power of 100 mW. INDEX TERMS underwater wireless optical communication, diffusing communication, AUVs, channel impulse response.
Published: 2021

45. Medium term post-bariatric surgery deficit of vitamin B12 is predicted by deficit at time of surgery

Author: Jean-Louis Guéant, Didier Quilliot, Zhen Li, Rosa-Maria Guéant-Rodriguez, David Meyre, Laurent Brunaud, Alice Mangeon, M.-A. Sirveaux, Darlène Antoine, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Chirurgie Digestive Hépatobiliaire et Endocrine [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service d'Endocrinologie - Diabète - Nutrition [CHRU Nancy], Unité Multidisciplinaire de Chirurgie de l'Obésité [CHRU Nancy], McMaster University [Hamilton, Ontario], Service d'Hépato-gastro-entérologie [CHRU Nancy], This work was financed by FHU ARRIMAGE, CHRU of Nancy and University of Lorraine, the AGIR grant of Universite de Lorraine and CHRU of Nancy and the French PIA project « Lorraine Universite d’Excellence », reference ANR-15-IDEX-04-LUE., IMPACT GEENAGE, ANR-15-IDEX-0004,LUE (ISITE),Lorraine Université d'Excellence(2016), ANR-15-IDEX-0004,LUE,Isite LUE(2015), CCSD, Accord Elsevier, and ISITE - Isite LUE - - LUE2015 - ANR-15-IDEX-0004 - IDEX - VALID
Subjects: Male, 0301 basic medicine, [SDV]Life Sciences [q-bio], Bariatric Surgery, Critical Care and Intensive Care Medicine, Postoperative Complications, 0302 clinical medicine, Risk Factors, Nonalcoholic fatty liver disease, Longitudinal Studies, Micronutrients, Postoperative Period, Prospective Studies, Homocysteine, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Nutrition and Dietetics, Middle Aged, Micronutrient, Obesity, Morbid, 3. Good health, [SDV] Life Sciences [q-bio], Vitamin B 12, Preoperative Period, Cohort, Deficiency, Female, Multivitamin, Cohort study, Adult, medicine.medical_specialty, Nutritional Status, 030209 endocrinology & metabolism, 03 medical and health sciences, Folates, Predictive Value of Tests, medicine, Vitamin D and neurology, Humans, Obesity, Vitamin B12, B12, 030109 nutrition & dietetics, business.industry, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Vitamin B 12 Deficiency, medicine.disease, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Surgery, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Dietary Supplements, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Follow-Up Studies
Abstract: Summary Background Patients with morbid obesity have a high risk of deficits in micronutrients, after bariatric surgery. The reasons why systematic use of multivitamin and trace element supplements cannot prevent all deficits are complex and should deserve more attention. Little is known about the influence of micronutrient deficits at surgery. Aim This present study aimed to explore the deficit in vitamin B12 vs other micronutrients during the follow-up of a French cohort of cases with bariatric surgery under systematic multivitamin/trace elements supplementation and to determine whether it was influenced by clinical, metabolic characteristics at surgery. Methods We prospectively enrolled obese patients with bariatric surgery (laparoscopic gastric bypass or laparoscopic sleeve gastrectomy) between 2013 and 2018 (OBESEPI/ALDEPI Cohort, NCT02663388). They received a daily multivitamin/micronutrients supplement. Follow-up data at 4 visits, 2, 12, 18 and 24 months after surgery, were collected. Results The highest rate of deficits was observed at visit 1 for vitamin D (35.7%), iron (21.9%) and folate (10.2%). Except B12, the deficits of all micronutrients decreased in later visits. In contrast, cases with vitamin B12 deficit decreased from 13.5% at surgery to 2.0% at visit 1, and increased in later visits, with a maximum of 12.0% at visit 3. Vitamin B12 concentration at surgery was the single predictor of B12 deficit at visit 3. It was also associated with age, and APRI score, an index of nonalcoholic fatty liver disease (NAFLD), in multivariate analysis. Conclusions The failure of systematic supplementation with multivitamin/trace elements tablets to prevent specific deficits illustrates the need for adapted specific supplementations, in some cases. The worsening of B12 deficit rate in the 18–24 months follow-up depends in part to low B12 at time of surgery. A special consideration should be devoted to this subset of patients. The cohort study was registered at clinicaltrials.gov as NCT02663388.
Published: 2021

46. Interpolation of property-values between electron numbers is inconsistent with ensemble averaging

Author: Ayers, Paul [Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario L8S 4M1 (Canada)]
Published: 2016
Full Text: View/download PDF

47. WE-FG-BRA-06: Systematic Study of Target Localization for Bioluminescence Tomography Guided Radiation Therapy for Preclinical Research

Author: Patterson, M [McMaster University, Hamilton, Ontario, CA (Canada)]
Published: 2016
Full Text: View/download PDF

48. Systematic study of target localization for bioluminescence tomography guided radiation therapy

Author: Patterson, Michael [Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario L8S 4L8 (Canada)]
Published: 2016
Full Text: View/download PDF

49. Irradiation of rainbow trout at early life stages results in trans-generational effects including the induction of a bystander effect in non-irradiated fish

Author: Mothersill, Carmel [Department of Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario (Canada)]
Published: 2016
Full Text: View/download PDF

50. Orbital energies and nuclear forces in <scp>DFT</scp> : Interpretation and validation

Author: Carlos Cárdenas, Patrick Chaquin, Paul W. Ayers, Rubén Laplaza, Julia Contreras-García, Laboratoire de chimie théorique (LCT), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of Zaragoza - Universidad de Zaragoza [Zaragoza], Universidad de Chile = University of Chile [Santiago] (UCHILE), Centro para el Desarrollo de la Nanociencia y Nanotecnología (CEDENNA), and McMaster University [Hamilton, Ontario]
Subjects: Valence (chemistry), 010304 chemical physics, [SDV]Life Sciences [q-bio], nuclear forces, nuclear Fukui function, General Chemistry, 010402 general chemistry, Antibonding molecular orbital, 01 natural sciences, 0104 chemical sciences, Specific orbital energy, Condensed Matter::Materials Science, Computational Mathematics, Atomic orbital, Ab initio quantum chemistry methods, Quantum mechanics, 0103 physical sciences, conceptual density functional theory, Physics::Atomic and Molecular Clusters, Nuclear force, dynamic orbital forces, Molecular orbital, Density functional theory, Physics::Chemical Physics, density functional theory
Abstract: International audience; The bonding and antibonding character of individual molecular orbitals has been previously shown to be related to their orbital energy derivatives with respect to nuclear coordinates, known as dynamical orbital forces. Albeit usually derived from Koopmans' theorem, in this work we show a more general derivation from conceptual DFT, which justifies application in a broader context. The consistency of the approach is validated numerically for valence orbitals in Kohn-Sham DFT. Then, we illustrate its usefulness by showcasing applications in aromatic and antiaromatic systems and in excited state chemistry. Overall, dynamical orbital forces can be used to interpret the results of routine ab initio calculations, be it wavefunction or density based, in terms of forces and occupations.
Published: 2020

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

25,613 results on '"McMaster University [Hamilton, Ontario]"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources