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1. Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques

Author

McMahan, Katherine, Wegmann, Frank, Aid, Malika, Sciacca, Michaela, Liu, Jinyan, Hachmann, Nicole P., Miller, Jessica, Jacob-Dolan, Catherine, Powers, Olivia, Hope, David, Wu, Cindy, Pereira, Juliana, Murdza, Tetyana, Mazurek, Camille R., Hoyt, Amelia, Boon, Adrianus C. M., Davis-Gardner, Meredith, Suthar, Mehul S., Martinot, Amanda J., Boursiquot, Mona, Cook, Anthony, Pessaint, Laurent, Lewis, Mark G., Andersen, Hanne, Tolboom, Jeroen, Serroyen, Jan, Solforosi, Laura, Costes, Lea M. M., Zahn, Roland C., and Barouch, Dan H.

Published
2024
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2. Booster with Ad26.COV2.S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques

Author

Solforosi, Laura, Costes, Lea M. M., Tolboom, Jeroen T. B. M., McMahan, Katherine, Anioke, Tochi, Hope, David, Murdza, Tetyana, Sciacca, Michaela, Bouffard, Emily, Barrett, Julia, Wu, Cindy, Hachmann, Nicole, Miller, Jessica, Yu, Jingyou, He, Xuan, Jacob-Dolan, Catherine, Huber, Sietske K. Rosendahl, Dekking, Liesbeth, Chamanza, Ronnie, Choi, Ying, Boer, Karin Feddes-de, Barouch, Dan H., Schuitemaker, Hanneke, Zahn, Roland C., and Wegmann, Frank

Published
2023
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3. Immunogenicity and protective efficacy of GBP510/AS03 vaccine against SARS-CoV-2 delta challenge in rhesus macaques

Author

Jacob-Dolan, Catherine, Yu, Jingyou, McMahan, Katherine, Giffin, Victoria, Chandrashekar, Abishek, Martinot, Amanda J., Anioke, Tochi, Powers, Olivia C., Hall, Kevin, Hope, David, Miller, Jessica, Hachmann, Nichole P., Chung, Benjamin, Gardner, Sarah, Sellers, Daniel, Barrett, Julia, Lewis, Mark G., Andersen, Hanne, Kleanthous, Harry, Seo, Ki-Woen, Lee, Su Jeen, Park, Yong Wook, Kim, Hun, and Barouch, Dan H.

Published
2023
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4. Mpox infection protects against re-challenge in rhesus macaques

Author

Aid, Malika, Sciacca, Michaela, McMahan, Katherine, Hope, David, Liu, Jinyan, Jacob-Dolan, Catherine, Powers, Olivia, Barrett, Julia, Wu, Cindy, Mutoni, Audrey, Murdza, Tetyana, Richter, Hannah, Velasco, Jason, Teow, Elyse, Boursiquot, Mona, Cook, Anthony, Orekov, Tatyana, Hamilton, Melissa, Pessaint, Laurent, Ryan, Alaina, Hayes, Tammy, Martinot, Amanda J., Seaman, Michael S., Lewis, Mark G., Andersen, Hanne, and Barouch, Dan H.

Published
2023
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5. Ad26.COV2.S and SARS-CoV-2 spike protein ferritin nanoparticle vaccine protect against SARS-CoV-2 Omicron BA.5 challenge in macaques

Author

Yu, Jingyou, Thomas, Paul V., Sciacca, Michaela, Wu, Cindy, Liu, Jinyan, He, Xuan, Miller, Jessica, Hachmann, Nicole P., Surve, Nehalee, McMahan, Katherine, Jacob-Dolan, Catherine, Powers, Olivia, Hall, Kevin, Barrett, Julia, Hope, David, Mazurek, Camille R., Murdza, Tetyana, Chang, William C., Golub, Emily, Rees, Phyllis A., Peterson, Caroline E., Hajduczki, Agnes, Chen, Wei-Hung, Martinez, Elizabeth J., Hussin, Elizabeth, Lange, Camille, Gong, Hua, Matyas, Gary R., Rao, Mangala, Suthar, Mehul, Boursiquot, Mona, Cook, Anthony, Pessaint, Laurent, Lewis, Mark G., Andersen, Hanne, Bolton, Diane L., Michael, Nelson L., Joyce, M. Gordon, Modjarrad, Kayvon, and Barouch, Dan H.

Published
2023
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6. Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice

Author

Dalvie, Neil C., Rodriguez-Aponte, Sergio A., Hartwell, Brittany L., Tostanoski, Lisa H., Biedermann, Andrew M., Crowell, Laura E., Kaur, Kawaljit, Kumru, Ozan S., Carter, Lauren, Yu, Jingyou, Chang, Aiquan, McMahan, Katherine, Courant, Thomas, Lebas, Celia, Lemnios, Ashley A., Rodrigues, Kristen A., Silva, Murillo, Johnston, Ryan S., Naranjo, Christopher A., Tracey, Mary Kate, Brady, Joseph R., Whittaker, Charles A., Yun, Dongsoo, Brunette, Natalie, Wang, Jing Yang, Walkey, Carl, Fiala, Brooke, Kar, Swagata, Porto, Maciel, Lok, Megan, Andersen, Hanne, Lewis, Mark G., Love, Kerry R., Camp, Danielle L., Silverman, Judith Maxwell, Kleanthous, Harry, Joshi, Sangeeta B., Volkin, David B., Dubois, Patrice M., Collin, Nicolas, King, Neil P., Barouch, Dan H., Irvine, Darrell J., and Love, J. Christopher

Published
2021

7. A genetically engineered, stem-cell-derived cellular vaccine

Author

Cooper, Amanda, Sidaway, Adam, Chandrashekar, Abishek, Latta, Elizabeth, Chakraborty, Krishnendu, Yu, Jingyou, McMahan, Katherine, Giffin, Victoria, Manickam, Cordelia, Kroll, Kyle, Mosher, Matthew, Reeves, R. Keith, Gam, Rihab, Arthofer, Elisa, Choudhry, Modassir, Henley, Tom, and Barouch, Dan H.

Published
2022
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9. Therapeutic efficacy of an Ad26/MVA vaccine with SIV gp140 protein and vesatolimod in ART-suppressed rhesus macaques

Author

Ventura, John D., Nkolola, Joseph P., Chandrashekar, Abishek, Borducchi, Erica N., Liu, Jinyan, Mercado, Noe B., Hope, David L., Giffin, Victoria M., McMahan, Katherine, Geleziunas, Romas, Murry, Jeffrey P., Yang, Yunling, Lewis, Mark G., Pau, Maria G., Wegmann, Frank, Schuitemaker, Hanneke, Fray, Emily J., Kumar, Mithra R., Siliciano, Janet D., Siliciano, Robert F., Robb, Merlin L., Michael, Nelson L., and Barouch, Dan H.

Published
2022
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11. SARS-CoV-2 XBB.1.5 mRNA booster vaccination elicits limited mucosal immunity.

Author

Lasrado, Ninaad, Rowe, Marjorie, McMahan, Katherine, Hachmann, Nicole P., Miller, Jessica, Jacob-Dolan, Catherine, Liu, Jinyan, Verrette, Brookelynne, Gotthardt, Kristin A., Ty, Darren M., Pereira, Juliana, Mazurek, Camille R., Hoyt, Amelia, Collier, Ai-ris Y., and Barouch, Dan H.

Subjects
SARS-CoV-2, BOOSTER vaccines, SARS-CoV-2 Omicron variant, VIRUS diseases, ANTIBODY formation
Abstract

Current COVID-19 vaccines provide robust protection against severe disease but minimal protection against acquisition of infection. Intramuscularly administered COVID-19 vaccines induce robust serum neutralizing antibodies (NAbs), but their ability to boost mucosal immune responses remains to be determined. In this study, we show that the XBB.1.5 messenger RNA (mRNA) boosters result in increased serum neutralization to multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in humans, including the dominant circulating variant JN.1. In contrast, we found that the XBB.1.5 mRNA booster did not augment mucosal NAbs or mucosal IgA responses, although acute SARS-CoV-2 XBB infection substantially increased mucosal antibody responses. These data demonstrate that current XBB.1.5 mRNA boosters substantially enhance peripheral antibody responses but do not robustly increase mucosal antibody responses. Our data highlight a separation between the peripheral and mucosal immune systems in humans and emphasize the importance of developing next-generation vaccines to augment mucosal immunity to protect against respiratory virus infections. Editor's summary: mRNA vaccines for SARS-CoV-2 elicit robust antibody responses in the circulation, which aid in protection from severe disease. However, the extent to which mRNA vaccines, which are delivered intramuscularly, can elicit mucosal immune responses is unclear. In a pair of papers, Declercq et al. and Lasrado et al. come to distinct conclusions. Using human nasal swab samples in both studies, Declercq et al. show that repeated vaccination for SARS-CoV-2 promotes neutralizing antibodies in the nose, whereas Lasrado et al. observed no obvious increase in neutralizing antibody titers after booster vaccination. These differing results may be due to the number of SARS-CoV-2 vaccinations or exposures, time since last exposure, and experimental approaches, but this pair of papers underscores the need to better understand the mucosal immune response in humans. —Courtney Malo [ABSTRACT FROM AUTHOR]

Published
2024
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12. Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine

Author

Gebre, Makda S., Rauch, Susanne, Roth, Nicole, Yu, Jingyou, Chandrashekar, Abishek, Mercado, Noe B., He, Xuan, Liu, Jinyan, McMahan, Katherine, Martinot, Amanda, Martinez, David R., Giffin, Victoria, Hope, David, Patel, Shivani, Sellers, Daniel, Sanborn, Owen, Barrett, Julia, Liu, Xiaowen, Cole, Andrew C., Pessaint, Laurent, Valentin, Daniel, Flinchbaugh, Zack, Yalley-Ogunro, Jake, Muench, Jeanne, Brown, Renita, Cook, Anthony, Teow, Elyse, Andersen, Hanne, Lewis, Mark G., Boon, Adrianus C. M., Baric, Ralph S., Mueller, Stefan O., Petsch, Benjamin, and Barouch, Dan H.

Published
2022
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13. Persistent Activation of Chronic Inflammatory Pathways in Long Covid

Author

Aid, Malika, primary, McMahan, Katherine, additional, Hachmann, Nicole, additional, Miller, Jessica, additional, Borducchi, Erica, additional, Hope, David, additional, Rowe, Marjorie, additional, Schonberg, Eleanor, additional, Thai, Siline, additional, Collier, Ai-ris, additional, Mullington, Janet, additional, and Barouch, Dan, additional

Published
2024
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14. Comparison of the immunogenicity and protective efficacy of ACAM2000, MVA, and vectored subunit vaccines for Mpox in rhesus macaques

Author

Jacob-Dolan, Catherine, primary, Ty, Darren, additional, Hope, David, additional, McMahan, Katherine, additional, Liu, Jinyan, additional, Powers, Olivia C., additional, Cotter, Catherine A., additional, Sciacca, Michela, additional, Wu, Cindy, additional, Borducchi, Erica, additional, Bouffard, Emily, additional, Richter, Hannah, additional, Velasco, Jason, additional, Teow, Elyse, additional, Boursiquot, Mona, additional, Cook, Anthony, additional, Feliciano, Karen, additional, Yalley-Ogunro, Jake, additional, Seaman, Michael S., additional, Pessiant, Laurent, additional, Lewis, Mark G., additional, Andersen, Hanne, additional, Moss, Bernard, additional, and Barouch, Dan H., additional

Published
2024
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15. Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques

Author

Yu, Jingyou, Tostanoski, Lisa H., Mercado, Noe B., McMahan, Katherine, Liu, Jinyan, Jacob-Dolan, Catherine, and Chandrashekar, Abishek

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation, Janssen COVID-19 Vaccine (Vaccine) -- Testing -- Physiological aspects
Abstract

The emergence of SARS-CoV-2 variants that partially evade neutralizing antibodies poses a threat to the efficacy of current COVID-19 vaccines.sup.1,2. The Ad26.COV2.S vaccine expresses a stabilized spike protein from the WA1/2020 strain of SARS-CoV-2, and has recently demonstrated protective efficacy against symptomatic COVID-19 in humans in several geographical regions--including in South Africa, where 95% of sequenced viruses in cases of COVID-19 were the B.1.351 variant.sup.3. Here we show that Ad26.COV2.S elicits humoral and cellular immune responses that cross-react with the B.1.351 variant and protects against B.1.351 challenge in rhesus macaques. Ad26.COV2.S induced lower binding and neutralizing antibodies against B.1.351 as compared to WA1/2020, but elicited comparable CD8 and CD4 T cell responses against the WA1/2020, B.1.351, B.1.1.7, P.1 and CAL.20C variants. B.1.351 infection of control rhesus macaques resulted in higher levels of virus replication in bronchoalveolar lavage and nasal swabs than did WA1/2020 infection. Ad26.COV2.S provided robust protection against both WA1/2020 and B.1.351, although we observed higher levels of virus in vaccinated macaques after B.1.351 challenge. These data demonstrate that Ad26.COV2.S provided robust protection against B.1.351 challenge in rhesus macaques. Our findings have important implications for vaccine control of SARS-CoV-2 variants of concern. SARS-CoV-2 challenge of rhesus macaques demonstrates that the Ad26.COV2.S vaccine induces robust protection against both the WA1/2020 isolate and the B.1.351 variant of concern., Author(s): Jingyou Yu [sup.1] , Lisa H. Tostanoski [sup.1] , Noe B. Mercado [sup.1] , Katherine McMahan [sup.1] , Jinyan Liu [sup.1] , Catherine Jacob-Dolan [sup.1] [sup.2] , Abishek Chandrashekar [...]

Published
2021
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16. Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans

Author

Alter, Galit, Yu, Jingyou, Liu, Jinyan, Chandrashekar, Abishek, Borducchi, Erica N., Tostanoski, Lisa H., and McMahan, Katherine

Subjects
Medical research, Medicine, Experimental, T cells -- Research, Immune response -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The Ad26.COV2.S vaccine.sup.1-3 has demonstrated clinical efficacy against symptomatic COVID-19, including against the B.1.351 variant that is partially resistant to neutralizing antibodies.sup.1. However, the immunogenicity of this vaccine in humans against SARS-CoV-2 variants of concern remains unclear. Here we report humoral and cellular immune responses from 20 Ad26.COV2.S vaccinated individuals from the COV1001 phase I-IIa clinical trial.sup.2 against the original SARS-CoV-2 strain WA1/2020 as well as against the B.1.1.7, CAL.20C, P.1 and B.1.351 variants of concern. Ad26.COV2.S induced median pseudovirus neutralizing antibody titres that were 5.0-fold and 3.3-fold lower against the B.1.351 and P.1 variants, respectively, as compared with WA1/2020 on day 71 after vaccination. Median binding antibody titres were 2.9-fold and 2.7-fold lower against the B.1.351 and P.1 variants, respectively, as compared with WA1/2020. Antibody-dependent cellular phagocytosis, complement deposition and natural killer cell activation responses were largely preserved against the B.1.351 variant. CD8 and CD4 T cell responses, including central and effector memory responses, were comparable among the WA1/2020, B.1.1.7, B.1.351, P.1 and CAL.20C variants. These data show that neutralizing antibody responses induced by Ad26.COV2.S were reduced against the B.1.351 and P.1 variants, but functional non-neutralizing antibody responses and T cell responses were largely preserved against SARS-CoV-2 variants. These findings have implications for vaccine protection against SARS-CoV-2 variants of concern. Analysis of the immunogenicity of the Ad26.COV2.S vaccine against the B1.351 and P.1 SARS-CoV-2 variants of concern shows reduced neutralization antibody titres, but comparable T cell responses and antibody-dependent effector functions., Author(s): Galit Alter [sup.1] [sup.2] , Jingyou Yu [sup.1] , Jinyan Liu [sup.1] , Abishek Chandrashekar [sup.1] , Erica N. Borducchi [sup.1] , Lisa H. Tostanoski [sup.1] , Katherine McMahan [...]

Published
2021
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17. Correlates of protection against SARS-CoV-2 in rhesus macaques

Author

McMahan, Katherine, Yu, Jingyou, Mercado, Noe B., Loos, Carolin, Tostanoski, Lisa H., Chandrashekar, Abishek, and Liu, Jinyan

Subjects
Vaccination -- Methods, Immune response -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Recent studies have reported the protective efficacy of both natural.sup.1 and vaccine-induced.sup.2-7 immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus macaques. However, the importance of humoral and cellular immunity for protection against infection with SARS-CoV-2 remains to be determined. Here we show that the adoptive transfer of purified IgG from convalescent rhesus macaques (Macaca mulatta) protects naive recipient macaques against challenge with SARS-CoV-2 in a dose-dependent fashion. Depletion of CD8.sup.+ T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity against rechallenge with SARS-CoV-2, which suggests a role for cellular immunity in the context of waning or subprotective antibody titres. These data demonstrate that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may contribute to protection if antibody responses are suboptimal. We also show that higher antibody titres are required for treatment of SARS-CoV-2 infection in macaques. These findings have implications for the development of SARS-CoV-2 vaccines and immune-based therapeutic agents. Adoptive transfer of purified IgG from convalescent macaques protects naive macaques against SARS-CoV-2 infection, and cellular immune responses contribute to protection against rechallenge with SARS-CoV-2., Author(s): Katherine McMahan [sup.1] , Jingyou Yu [sup.1] , Noe B. Mercado [sup.1] , Carolin Loos [sup.2] [sup.3] , Lisa H. Tostanoski [sup.1] , Abishek Chandrashekar [sup.1] , Jinyan Liu [...]

Published
2021
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18. Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques

Author

McMahan, Katherine, primary, Wegmann, Frank, additional, Aid, Malika, additional, Sciacca, Michaela, additional, Liu, Jinyan, additional, Hachmann, Nicole P., additional, Miller, Jessica, additional, Jacob-Dolan, Catherine, additional, Powers, Olivia, additional, Hope, David, additional, Wu, Cindy, additional, Pereira, Juliana, additional, Murdza, Tetyana, additional, Mazurek, Camille R., additional, Hoyt, Amelia, additional, Boon, Adrianus C. M., additional, Davis-Gardner, Meredith, additional, Suthar, Mehul S., additional, Martinot, Amanda J., additional, Boursiquot, Mona, additional, Cook, Anthony, additional, Pessaint, Laurent, additional, Lewis, Mark G., additional, Andersen, Hanne, additional, Tolboom, Jeroen, additional, Serroyen, Jan, additional, Solforosi, Laura, additional, Costes, Lea M. M., additional, Zahn, Roland C., additional, and Barouch, Dan H., additional

Published
2023
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19. Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques

Author

Cadena, Anthony M., Ventura, John D., Abbink, Peter, Borducchi, Erica N., Tuyishime, Hubert, Mercado, Noe B., Walker-Sperling, Victoria, Siamatu, Mazuba, Liu, Po-Ting, Chandrashekar, Abishek, Nkolola, Joseph P., McMahan, Katherine, Kordana, Nicole, Hamza, Venous, Bondzie, Esther A., Fray, Emily, Kumar, Mithra, Fischinger, Stephanie, Shin, Sally A., Lewis, Mark G., Siliciano, Robert F., Alter, Galit, and Barouch, Dan H.

Published
2021
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20. Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

Author

Tostanoski, Lisa H., Wegmann, Frank, Martinot, Amanda J., Loos, Carolin, McMahan, Katherine, Mercado, Noe B., and Yu, Jingyou

Subjects
Biological sciences, Health
Abstract

Coronavirus disease 2019 (COVID-19) in humans is often a clinically mild illness, but some individuals develop severe pneumonia, respiratory failure and death.sup.1-4. Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in hamsters.sup.5-7 and nonhuman primates.sup.8-10 have generally reported mild clinical disease, and preclinical SARS-CoV-2 vaccine studies have demonstrated reduction of viral replication in the upper and lower respiratory tracts in nonhuman primates.sup.11-13. Here we show that high-dose intranasal SARS-CoV-2 infection in hamsters results in severe clinical disease, including high levels of virus replication in tissues, extensive pneumonia, weight loss and mortality in a subset of animals. A single immunization with an adenovirus serotype 26 vector-based vaccine expressing a stabilized SARS-CoV-2 spike protein elicited binding and neutralizing antibody responses and protected against SARS-CoV-2-induced weight loss, pneumonia and mortality. These data demonstrate vaccine protection against SARS-CoV-2 clinical disease. This model should prove useful for preclinical studies of SARS-CoV-2 vaccines, therapeutics and pathogenesis. A single immunization with an adenovirus vector-based vaccine expressing a stabilized SARS-CoV-2 spike protein induces protection against SARS-CoV-2-induced weight loss, pneumonia and mortality in hamsters., Author(s): Lisa H. Tostanoski [sup.1] , Frank Wegmann [sup.2] , Amanda J. Martinot [sup.1] [sup.3] , Carolin Loos [sup.4] [sup.5] , Katherine McMahan [sup.1] , Noe B. Mercado [sup.1] , [...]

Published
2020
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21. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Author

Mercado, Noe B., Zahn, Roland, Wegmann, Frank, Loos, Carolin, Chandrashekar, Abishek, Yu, Jingyou, Liu, Jinyan, Peter, Lauren, McMahan, Katherine, Tostanoski, Lisa H., He, Xuan, Martinez, David R., Rutten, Lucy, Bos, Rinke, van Manen, Danielle, Vellinga, Jort, Custers, Jerome, Langedijk, Johannes P., Kwaks, Ted, Bakkers, Mark J. G., Zuijdgeest, David, Rosendahl Huber, Sietske K., Atyeo, Caroline, Fischinger, Stephanie, Burke, John S., Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., Hoffman, Emily, Jacob-Dolan, Catherine, Kirilova, Marinela, Li, Zhenfeng, Lin, Zijin, Mahrokhian, Shant H., Maxfield, Lori F., Nampanya, Felix, Nityanandam, Ramya, Nkolola, Joseph P., Patel, Shivani, Ventura, John D., Verrington, Kaylee, Wan, Huahua, Pessaint, Laurent, Van Ry, Alex, Blade, Kelvin, Strasbaugh, Amanda, Cabus, Mehtap, Brown, Renita, Cook, Anthony, Zouantchangadou, Serge, Teow, Elyse, Andersen, Hanne, Lewis, Mark G., Cai, Yongfei, Chen, Bing, Schmidt, Aaron G., Reeves, R. Keith, Baric, Ralph S., Lauffenburger, Douglas A., Alter, Galit, Stoffels, Paul, Mammen, Mathai, Van Hoof, Johan, Schuitemaker, Hanneke, and Barouch, Dan H.

Published
2020
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22. Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys

Author

Borducchi, Erica N., Liu, Jinyan, Nkolola, Joseph P., Cadena, Anthony M., Yu, Wen-Han, Fischinger, Stephanie, Broge, Thomas, Abbink, Peter, Mercado, Noe B., Chandrashekar, Abishek, Jetton, David, Peter, Lauren, McMahan, Katherine, Moseley, Edward T., Bekerman, Elena, Hesselgesser, Joseph, Li, Wenjun, Lewis, Mark G., Alter, Galit, Geleziunas, Romas, and Barouch, Dan H.

Published
2018
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23. Defining the determinants of protection against SARS-CoV-2 infection and viral control in a dose-down Ad26.CoV2.S vaccine study in nonhuman primates

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Zhu, Daniel Y, Gorman, Matthew J, Yuan, Dansu, Yu, Jingyou, Mercado, Noe B, McMahan, Katherine, Borducchi, Erica N, Lifton, Michelle, Liu, Jinyan, Nampanya, Felix, Patel, Shivani, Peter, Lauren, Tostanoski, Lisa H, Pessaint, Laurent, Van Ry, Alex, Finneyfrock, Brad, Velasco, Jason, Teow, Elyse, Brown, Renita, Cook, Anthony, Andersen, Hanne, Lewis, Mark G, Lauffenburger, Douglas A, Barouch, Dan H, Alter, Galit, Massachusetts Institute of Technology. Department of Biological Engineering, Zhu, Daniel Y, Gorman, Matthew J, Yuan, Dansu, Yu, Jingyou, Mercado, Noe B, McMahan, Katherine, Borducchi, Erica N, Lifton, Michelle, Liu, Jinyan, Nampanya, Felix, Patel, Shivani, Peter, Lauren, Tostanoski, Lisa H, Pessaint, Laurent, Van Ry, Alex, Finneyfrock, Brad, Velasco, Jason, Teow, Elyse, Brown, Renita, Cook, Anthony, Andersen, Hanne, Lewis, Mark G, Lauffenburger, Douglas A, Barouch, Dan H, and Alter, Galit

Abstract

Despite the rapid creation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vaccines, the precise correlates of immunity against severe Coronavirus Disease 2019 (COVID-19) are still unknown. Neutralizing antibodies represent a robust surrogate of protection in early Phase III studies, but vaccines provide protection prior to the evolution of neutralization, vaccines provide protection against variants that evade neutralization, and vaccines continue to provide protection against disease severity in the setting of waning neutralizing titers. Thus, in this study, using an Ad26.CoV2.S dose-down approach in nonhuman primates (NHPs), the role of neutralization, Fc effector function, and T-cell immunity were collectively probed against infection as well as against viral control. While dosing-down minimally impacted neutralizing and binding antibody titers, Fc receptor binding and functional antibody levels were induced in a highly dose-dependent manner. Neutralizing antibody and Fc receptor binding titers, but minimally T cells, were linked to the prevention of transmission. Conversely, Fc receptor binding/function and T cells were linked to antiviral control, with a minimal role for neutralization. These data point to dichotomous roles of neutralization and T-cell function in protection against transmission and disease severity and a continuous role for Fc effector function as a correlate of immunity key to halting and controlling SARS-CoV-2 and emerging variants.

Published
2023

24. Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters

Author

Collier, Ai-ris Y., primary, Miller, Jessica, additional, Hachmann, Nicole P., additional, McMahan, Katherine, additional, Liu, Jinyan, additional, Bondzie, Esther A., additional, Gallup, Lydia, additional, Rowe, Marjorie, additional, Schonberg, Eleanor, additional, Thai, Siline, additional, Barrett, Julia, additional, Borducchi, Erica N., additional, Bouffard, Emily, additional, Jacob-Dolan, Catherine, additional, Mazurek, Camille R., additional, Mutoni, Audrey, additional, Powers, Olivia, additional, Sciacca, Michaela, additional, Surve, Nehalee, additional, VanWyk, Haley, additional, Wu, Cindy, additional, and Barouch, Dan H., additional

Published
2023
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25. Publisher Correction: Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Author

Mercado, Noe B., Zahn, Roland, Wegmann, Frank, Loos, Carolin, Chandrashekar, Abishek, Yu, Jingyou, Liu, Jinyan, Peter, Lauren, McMahan, Katherine, Tostanoski, Lisa H., He, Xuan, Martinez, David R., Rutten, Lucy, Bos, Rinke, van Manen, Danielle, Vellinga, Jort, Custers, Jerome, Langedijk, Johannes P., Kwaks, Ted, Bakkers, Mark J. G., Zuijdgeest, David, Huber, Sietske K. Rosendahl, Atyeo, Caroline, Fischinger, Stephanie, Burke, John S., Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Bondzie, Esther A., Dagotto, Gabriel, Gebre, Makda S., Hoffman, Emily, Jacob-Dolan, Catherine, Kirilova, Marinela, Li, Zhenfeng, Lin, Zijin, Mahrokhian, Shant H., Maxfield, Lori F., Nampanya, Felix, Nityanandam, Ramya, Nkolola, Joseph P., Patel, Shivani, Ventura, John D., Verrington, Kaylee, Wan, Huahua, Pessaint, Laurent, Van Ry, Alex, Blade, Kelvin, Strasbaugh, Amanda, Cabus, Mehtap, Brown, Renita, Cook, Anthony, Zouantchangadou, Serge, Teow, Elyse, Andersen, Hanne, Lewis, Mark G., Cai, Yongfei, Chen, Bing, Schmidt, Aaron G., Reeves, R. Keith, Baric, Ralph S., Lauffenburger, Douglas A., Alter, Galit, Stoffels, Paul, Mammen, Mathai, Van Hoof, Johan, Schuitemaker, Hanneke, and Barouch, Dan H.

Published
2021
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26. Protection against SARS-CoV-2 Omicron BA.1 variant challenge in macaques by prime-boost vaccination with Ad26.COV2.S and SpFN

Author

Yu, Jingyou, primary, Thomas, Paul V., additional, McMahan, Katherine, additional, Jacob-Dolan, Catherine, additional, Liu, Jinyan, additional, He, Xuan, additional, Hope, David, additional, Martinez, Elizabeth J., additional, Chen, Wei-Hung, additional, Sciacca, Michaela, additional, Hachmann, Nicole P., additional, Lifton, Michelle, additional, Miller, Jessica, additional, Powers, Olivia C., additional, Hall, Kevin, additional, Wu, Cindy, additional, Barrett, Julia, additional, Swafford, Isabella, additional, Currier, Jeffrey R., additional, King, Jocelyn, additional, Corbitt, Courtney, additional, Chang, William C., additional, Golub, Emily, additional, Rees, Phyllis A., additional, Peterson, Caroline E., additional, Hajduczki, Agnes, additional, Hussin, Elizabeth, additional, Lange, Camille, additional, Gong, Hua, additional, Matyas, Gary R., additional, Rao, Mangala, additional, Paquin-Proulx, Dominic, additional, Gromowski, Gregory D., additional, Lewis, Mark G., additional, Andersen, Hanne, additional, Davis-Gardner, Meredith, additional, Suthar, Mehul S., additional, Michael, Nelson L., additional, Bolton, Diane L., additional, Joyce, M. Gordon, additional, Modjarrad, Kayvon, additional, and Barouch, Dan H., additional

Published
2022
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27. CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques

Author

Liu, Jinyan, primary, Yu, Jingyou, additional, McMahan, Katherine, additional, Jacob-Dolan, Catherine, additional, He, Xuan, additional, Giffin, Victoria, additional, Wu, Cindy, additional, Sciacca, Michaela, additional, Powers, Olivia, additional, Nampanya, Felix, additional, Miller, Jessica, additional, Lifton, Michelle, additional, Hope, David, additional, Hall, Kevin, additional, Hachmann, Nicole P., additional, Chung, Benjamin, additional, Anioke, Tochi, additional, Li, Wenjun, additional, Muench, Jeanne, additional, Gamblin, Adrienne, additional, Boursiquot, Mona, additional, Cook, Anthony, additional, Lewis, Mark G., additional, Andersen, Hanne, additional, and Barouch, Dan H., additional

Published
2022
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28. Booster immunization with Ad26.COV2.S or Omicron adapted vaccine enhanced immune responses and efficacy against SARS-CoV-2 Omicron in non-human primates

Author

Solforosi, Laura, primary, Costes, Lea, additional, Tolboom, Jeroen, additional, McMahan, Katherine, additional, Anioke, Tochi, additional, Hope, David, additional, Murdza, Tetyana, additional, Sciacca, Michaela, additional, Bouffard, Emily, additional, Barrett, Julia, additional, Wu, Cindy, additional, Hachmann, Nicole, additional, Miller, Jessica, additional, Yu, Jingyou, additional, He, Xuan, additional, Jacob-Dolan, Catherine, additional, Huber, Sietske Rosendahl, additional, Dekking, Liesbeth, additional, Chamanza, Ronnie, additional, Choi, Ying, additional, Boer, Karin Feddes-de, additional, Barouch, Dan, additional, Schuitemaker, Hanneke, additional, Zahn, Roland, additional, and Wegmann, Frank, additional

Published
2022
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29. Immunogenicity of the BA.5 Bivalent mRNA Vaccine Boosters

Author

Collier, Ai-ris Y., primary, Miller, Jessica, additional, Hachmann, Nicole P., additional, McMahan, Katherine, additional, Liu, Jinyan, additional, Bondzie, Esther Apraku, additional, Gallup, Lydia, additional, Rowe, Marjorie, additional, Schonberg, Eleanor, additional, Thai, Siline, additional, Barrett, Julia, additional, Borducchi, Erica N., additional, Bouffard, Emily, additional, Jacob-Dolan, Catherine, additional, Mazurek, Camille R., additional, Mutoni, Audrey, additional, Powers, Olivia, additional, Sciacca, Michaela, additional, Surve, Nehalee, additional, VanWyk, Haley, additional, Wu, Cindy, additional, and Barouch, Dan H., additional

Published
2022
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30. A bivalent SARS-CoV-2 monoclonal antibody combination does not affect the immunogenicity of a vector-based COVID-19 vaccine in macaques

Author

Nkolola, Joseph P., primary, Yu, Jingyou, additional, Wan, Huahua, additional, Chang, Aiquan, additional, McMahan, Katherine, additional, Anioke, Tochi, additional, Jacob-Dolan, Catherine, additional, Powers, Olivia, additional, Ye, Tianyi, additional, Chandrashekar, Abishek, additional, Sellers, Daniel, additional, Barrett, Julia, additional, Loo, Yueh-Ming, additional, Esser, Mark T., additional, Carnahan, Robert H., additional, Crowe, James E., additional, and Barouch, Dan H., additional

Published
2022
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31. Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail

Author

Julg, Boris, Liu, Po-Ting, Wagh, Kshitij, Fischer, William M., Abbink, Peter, Mercado, Noe B., Whitney, James B., Nkolola, Joseph P., McMahan, Katherine, Tartaglia, Lawrence J., Borducchi, Erica N., Khatiwada, Shreeya, Kamath, Megha, LeSuer, Jake A., Seaman, Michael S., Schmidt, Stephen D., Mascola, John R., Burton, Dennis R., Korber, Bette T., and Barouch, Dan H.

Published
2017
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32. Durability of Heterologous and Homologous COVID-19 Vaccine Boosts

Author

Tan, C. Sabrina, primary, Collier, Ai-ris Y., additional, Yu, Jingyou, additional, Liu, Jinyan, additional, Chandrashekar, Abishek, additional, McMahan, Katherine, additional, Jacob-Dolan, Catherine, additional, He, Xuan, additional, Roy, Vicky, additional, Hauser, Blake M., additional, Munt, Jennifer E., additional, Mallory, Michael L., additional, Mattocks, Melissa, additional, Powers, John M., additional, Meganck, Rita M., additional, Rowe, Marjorie, additional, Hemond, Rachel, additional, Bondzie, Esther A., additional, Jaegle, Kate H., additional, Baric, Ralph S., additional, Schmidt, Aaron G., additional, Alter, Galit, additional, Le Gars, Mathieu, additional, Sadoff, Jerald, additional, and Barouch, Dan H., additional

Published
2022
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34. Reduced SARS-CoV-2 disease outcomes in Syrian hamsters receiving immune sera: Quantitative image analysis in pathologic assessments

Author

Piedra-Mora, Cesar, primary, Robinson, Sally R., additional, Tostanoski, Lisa H., additional, Dayao, Denise A. E., additional, Chandrashekar, Abishek, additional, Bauer, Katherine, additional, Wrijil, Linda, additional, Ducat, Sarah, additional, Hayes, Tammy, additional, Yu, Jingyou, additional, Bondzie, Esther A., additional, McMahan, Katherine, additional, Sellers, Daniel, additional, Giffin, Victoria, additional, Hope, David, additional, Nampanya, Felix, additional, Mercado, Noe B., additional, Kar, Swagata, additional, Andersen, Hanne, additional, Tzipori, Saul, additional, Barouch, Dan H., additional, and Martinot, Amanda J., additional

Published
2022
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35. Defining the determinants of protection against SARS-CoV-2 infection and viral control in a dose-down Ad26.CoV2.S vaccine study in nonhuman primates

Author

Zhu, Daniel Y., primary, Gorman, Matthew J., additional, Yuan, Dansu, additional, Yu, Jingyou, additional, Mercado, Noe B., additional, McMahan, Katherine, additional, Borducchi, Erica N., additional, Lifton, Michelle, additional, Liu, Jinyan, additional, Nampanya, Felix, additional, Patel, Shivani, additional, Peter, Lauren, additional, Tostanoski, Lisa H., additional, Pessaint, Laurent, additional, Van Ry, Alex, additional, Finneyfrock, Brad, additional, Velasco, Jason, additional, Teow, Elyse, additional, Brown, Renita, additional, Cook, Anthony, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Lauffenburger, Douglas A., additional, Barouch, Dan H., additional, and Alter, Galit, additional

Published
2022
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36. Characterization of immune responses in fully vaccinated individuals after breakthrough infection with the SARS-CoV-2 delta variant

Author

Collier, Ai-ris Y., primary, Brown, Catherine M., additional, McMahan, Katherine A., additional, Yu, Jingyou, additional, Liu, Jinyan, additional, Jacob-Dolan, Catherine, additional, Chandrashekar, Abishek, additional, Tierney, Dylan, additional, Ansel, Jessica L., additional, Rowe, Marjorie, additional, Sellers, Daniel, additional, Ahmad, Kunza, additional, Aguayo, Ricardo, additional, Anioke, Tochi, additional, Gardner, Sarah, additional, Siamatu, Mazuba, additional, Bermudez-Rivera, Lorraine, additional, Hacker, Michele R., additional, Madoff, Lawrence C., additional, and Barouch, Dan H., additional

Published
2022
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37. Vaccine protection against the SARS-CoV-2 Omicron variant in macaques

Author

Chandrashekar, Abishek, primary, Yu, Jingyou, additional, McMahan, Katherine, additional, Jacob-Dolan, Catherine, additional, Liu, Jinyan, additional, He, Xuan, additional, Hope, David, additional, Anioke, Tochi, additional, Barrett, Julia, additional, Chung, Benjamin, additional, Hachmann, Nicole P., additional, Lifton, Michelle, additional, Miller, Jessica, additional, Powers, Olivia, additional, Sciacca, Michaela, additional, Sellers, Daniel, additional, Siamatu, Mazuba, additional, Surve, Nehalee, additional, VanWyk, Haley, additional, Wan, Huahua, additional, Wu, Cindy, additional, Pessaint, Laurent, additional, Valentin, Daniel, additional, Van Ry, Alex, additional, Muench, Jeanne, additional, Boursiquot, Mona, additional, Cook, Anthony, additional, Velasco, Jason, additional, Teow, Elyse, additional, Boon, Adrianus C.M., additional, Suthar, Mehul S., additional, Jain, Neharika, additional, Martinot, Amanda J., additional, Lewis, Mark G., additional, Andersen, Hanne, additional, and Barouch, Dan H., additional

Published
2022
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38. A homologous or variant booster vaccine after Ad26.COV2.S immunization enhances SARS-CoV-2–specific immune responses in rhesus macaques

Author

He, Xuan, primary, Aid, Malika, additional, Chandrashekar, Abishek, additional, Yu, Jingyou, additional, McMahan, Katherine, additional, Wegmann, Frank, additional, Jacob-Dolan, Catherine, additional, Maron, Jenny S., additional, Atyeo, Caroline, additional, Wan, Huahua, additional, Sellers, Daniel, additional, Liu, Jinyan, additional, Lifton, Michelle, additional, Gardner, Sarah, additional, Bondzie, Esther A., additional, Barrett, Julia, additional, Ahmad, Kunza, additional, Anioke, Tochi, additional, Yalley-Ogunro, Jake, additional, Muench, Jeanne, additional, Goode, Adrienne, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Alter, Galit, additional, Schuitemaker, Hanneke, additional, Zahn, Roland, additional, and Barouch, Dan H., additional

Published
2022
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39. SARS-CoV-2 receptor binding domain displayed on HBsAg virus–like particles elicits protective immunity in macaques

Author

Dalvie, Neil C., primary, Tostanoski, Lisa H., additional, Rodriguez-Aponte, Sergio A., additional, Kaur, Kawaljit, additional, Bajoria, Sakshi, additional, Kumru, Ozan S., additional, Martinot, Amanda J., additional, Chandrashekar, Abishek, additional, McMahan, Katherine, additional, Mercado, Noe B., additional, Yu, Jingyou, additional, Chang, Aiquan, additional, Giffin, Victoria M., additional, Nampanya, Felix, additional, Patel, Shivani, additional, Bowman, Lesley, additional, Naranjo, Christopher A., additional, Yun, Dongsoo, additional, Flinchbaugh, Zach, additional, Pessaint, Laurent, additional, Brown, Renita, additional, Velasco, Jason, additional, Teow, Elyse, additional, Cook, Anthony, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Camp, Danielle L., additional, Silverman, Judith Maxwell, additional, Nagar, Gaurav S., additional, Rao, Harish D., additional, Lothe, Rakesh R., additional, Chandrasekharan, Rahul, additional, Rajurkar, Meghraj P., additional, Shaligram, Umesh S., additional, Kleanthous, Harry, additional, Joshi, Sangeeta B., additional, Volkin, David B., additional, Biswas, Sumi, additional, Love, J. Christopher, additional, and Barouch, Dan H., additional

Published
2022
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40. Publisher Correction: Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys

Author

Borducchi, Erica N., Liu, Jinyan, Nkolola, Joseph P., Cadena, Anthony M., Yu, Wen-Han, Fischinger, Stephanie, Broge, Thomas, Abbink, Peter, Mercado, Noe B., Chandrashekar, Abishek, Jetton, David, Peter, Lauren, McMahan, Katherine, Moseley, Edward T., Bekerman, Elena, Hesselgesser, Joseph, Li, Wenjun, Lewis, Mark G., Alter, Galit, Geleziunas, Romas, and Barouch, Dan H.

Published
2018
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41. Reduced Pathogenicity of the SARS-CoV-2 Omicron Variant in Hamsters

Author

McMahan, Katherine, primary, Giffin, Victoria, additional, Tostanoski, Lisa H., additional, Chung, Benjamin, additional, Siamatu, Mazuba, additional, Suthar, Mehul S., additional, Halfmann, Peter, additional, Kawaoka, Yoshihiro, additional, Piedra-Mora, Cesar, additional, Martinot, Amanda J., additional, Kar, Swagata, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, and Barouch, Dan H., additional

Published
2022
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43. A Novel CRISPR-Engineered, Stem Cell-Derived Cellular Vaccine

Author

Chakraborty, Krishnendu, primary, Chandrashekar, Abishek, additional, Sidaway, Adam, additional, Latta, Elizabeth, additional, Yu, Jingyou, additional, McMahan, Katherine, additional, Manickam, Cordelia, additional, Kroll, Kyle, additional, Mosher, Matthew, additional, Reeves, R. Keith, additional, Gam, Rihab, additional, Arthofer, Elisa, additional, Choudhry, Modassir, additional, Barouch, Dan H., additional, and Henley, Tom, additional

Published
2021
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44. Homologous and Heterologous Vaccine Boost Strategies for Humoral and Cellular Immunologic Coverage of the SARS-CoV-2 Omicron Variant

Author

Tan, C. Sabrina, primary, Collier, Ai-ris Y., additional, Liu, Jinyan, additional, Yu, Jingyou, additional, Chandrashekar, Abishek, additional, McMahan, Katherine, additional, Wan, Huahua, additional, He, Xuan, additional, Jacob-Dolan, Catherine, additional, Sellers, Daniel, additional, Ventura, John D., additional, Bartsch, Yannic, additional, Hauser, Blake M., additional, Munt, Jennifer E., additional, Mattocks, Melissa, additional, Stephenson, Kathryn E., additional, Vidal, Samuel J., additional, Jaegle, Kate, additional, Rowe, Marjorie, additional, Hemond, Rachel, additional, Rivera, Lorraine Bermudez, additional, Anioke, Tochi, additional, Barrett, Julia, additional, Chung, Benjamin, additional, Gardner, Sarah, additional, Gebre, Makda S., additional, Hachmann, Nicole, additional, Lifton, Michelle, additional, Miller, Jessica, additional, Nampanya, Felix, additional, Powers, Olivia, additional, Sciacca, Michaela, additional, Siamatu, Mazuba, additional, Surve, Nehalee, additional, Tostanoski, Lisa H., additional, VanWyk, Haley, additional, Wu, Cindy, additional, Baric, Ralph S., additional, Schmidt, Aaron G., additional, Alter, Galit, additional, and Barouch, Dan H., additional

Published
2021
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45. Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine

Author

Gebre, Makda S., primary, Rauch, Susanne, additional, Roth, Nicole, additional, Yu, Jingyou, additional, Chandrashekar, Abishek, additional, Mercado, Noe B., additional, He, Xuan, additional, Liu, Jinyan, additional, McMahan, Katherine, additional, Martinot, Amanda, additional, Martinez, David R., additional, Giffin, Victoria, additional, Hope, David, additional, Patel, Shivani, additional, Sellers, Daniel, additional, Sanborn, Owen, additional, Barrett, Julia, additional, Liu, Xiaowen, additional, Cole, Andrew C., additional, Pessaint, Laurent, additional, Valentin, Daniel, additional, Flinchbaugh, Zack, additional, Yalley-Ogunro, Jake, additional, Muench, Jeanne, additional, Brown, Renita, additional, Cook, Anthony, additional, Teow, Elyse, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Boon, Adrianus C. M., additional, Baric, Ralph S., additional, Mueller, Stefan O., additional, Petsch, Benjamin, additional, and Barouch, Dan H., additional

Published
2021
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46. Coronavirus Disease 2019 Messenger RNA Vaccine Immunogenicity in Immunosuppressed Individuals

Author

Collier, Ai-ris Y, primary, Yu, Jingyou, additional, McMahan, Katherine, additional, Liu, Jinyan, additional, Atyeo, Caroline, additional, Ansel, Jessica L, additional, Fricker, Zachary P, additional, Pavlakis, Martha, additional, Curry, Michael P, additional, Jacob-Dolan, Catherine, additional, Patel, Het, additional, Sellers, Daniel, additional, Barrett, Julia, additional, Rowe, Marjorie, additional, Ahmad, Kunza, additional, Gompers, Annika, additional, Aguayo, Ricardo, additional, Chandrashekar, Abishek, additional, Alter, Galit, additional, Hacker, Michele R, additional, and Barouch, Dan H, additional

Published
2021
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47. Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines

Author

Collier, Ai-ris Y., primary, Yu, Jingyou, additional, McMahan, Katherine, additional, Liu, Jinyan, additional, Chandrashekar, Abishek, additional, Maron, Jenny S., additional, Atyeo, Caroline, additional, Martinez, David R., additional, Ansel, Jessica L., additional, Aguayo, Ricardo, additional, Rowe, Marjorie, additional, Jacob-Dolan, Catherine, additional, Sellers, Daniel, additional, Barrett, Julia, additional, Ahmad, Kunza, additional, Anioke, Tochi, additional, VanWyk, Haley, additional, Gardner, Sarah, additional, Powers, Olivia, additional, Bondzie, Esther A., additional, Wan, Huahua, additional, Baric, Ralph S., additional, Alter, Galit, additional, Hacker, Michele R., additional, and Barouch, Dan H., additional

Published
2021
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48. Protective Efficacy of Rhesus Adenovirus COVID-19 Vaccines against Mouse-Adapted SARS-CoV-2

Author

Tostanoski, Lisa H., primary, Gralinski, Lisa E., additional, Martinez, David R., additional, Schaefer, Alexandra, additional, Mahrokhian, Shant H., additional, Li, Zhenfeng, additional, Nampanya, Felix, additional, Wan, Huahua, additional, Yu, Jingyou, additional, Chang, Aiquan, additional, Liu, Jinyan, additional, McMahan, Katherine, additional, Ventura, John D., additional, Dinnon, Kenneth H., additional, Leist, Sarah R., additional, Baric, Ralph S., additional, and Barouch, Dan H., additional

Published
2021
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49. Immunity elicited by natural infection or Ad26.COV2.S vaccination protects hamsters against SARS-CoV-2 variants of concern

Author

Tostanoski, Lisa H., primary, Yu, Jingyou, additional, Mercado, Noe B., additional, McMahan, Katherine, additional, Jacob-Dolan, Catherine, additional, Martinot, Amanda J., additional, Piedra-Mora, Cesar, additional, Anioke, Tochi, additional, Chang, Aiquan, additional, Giffin, Victoria M., additional, Hope, David L., additional, Wan, Huahua, additional, Bondzie, Esther A., additional, Mahrokhian, Shant H., additional, Wrijil, Linda M., additional, Bauer, Katherine, additional, Pessaint, Laurent, additional, Porto, Maciel, additional, Piegols, Joseph, additional, Faudree, Andrew, additional, Spence, Brittany, additional, Kar, Swagata, additional, Amanat, Fatima, additional, Krammer, Florian, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Wegmann, Frank, additional, Zahn, Roland, additional, Schuitemaker, Hanneke, additional, and Barouch, Dan H., additional

Published
2021
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50. Prior infection with SARS-CoV-2 WA1/2020 partially protects rhesus macaques against reinfection with B.1.1.7 and B.1.351 variants

Author

Chandrashekar, Abishek, primary, Liu, Jinyan, additional, Yu, Jingyou, additional, McMahan, Katherine, additional, Tostanoski, Lisa H., additional, Jacob-Dolan, Catherine, additional, Mercado, Noe B., additional, Anioke, Tochi, additional, Chang, Aiquan, additional, Gardner, Sarah, additional, Giffin, Victoria M., additional, Hope, David L., additional, Nampanya, Felix, additional, Patel, Shivani, additional, Sanborn, Owen, additional, Sellers, Daniel, additional, Wan, Huahua, additional, Martinot, Amanda J., additional, Baczenas, John J., additional, O’Connor, Shelby L., additional, Pessaint, Laurent, additional, Valentin, Daniel, additional, Espina, Benjamin, additional, Wattay, Lauren, additional, Ferrari, Maria G., additional, Brown, Renita, additional, Cook, Anthony, additional, Bueno-Wilkerson, Deandre, additional, Teow, Elyse, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, and Barouch, Dan H., additional

Published
2021
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