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Your search keyword '"McLelland, Gian-Luca"' showing total 15 results
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15 results on '"McLelland, Gian-Luca"'

2. Identification of an alternative triglyceride biosynthesis pathway

Author

McLelland, Gian-Luca, Lopez-Osias, Marta, Verzijl, Cristy R. C., Ellenbroek, Brecht D., Oliveira, Rafaela A., Boon, Nicolaas J., Dekker, Marleen, van den Hengel, Lisa G., Ali, Rahmen, Janssen, Hans, Song, Ji-Ying, Krimpenfort, Paul, van Zutphen, Tim, Jonker, Johan W., and Brummelkamp, Thijn R.

Published
2023
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3. Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation

Author

Liu, Julio C.Y., primary, Ackermann, Leena, additional, Hoffmann, Saskia, additional, Gal, Zita, additional, Hendriks, Ivo A., additional, Jain, Charu, additional, Morlot, Louise, additional, Tatham, Michael H, additional, McLelland, Gian-Luca, additional, Hay, Ronald Thomas, additional, Nielsen, Michael L, additional, Brummelkamp, Thijn R, additional, Haahr, Peter, additional, and Mailand, Niels, additional

Published
2023
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7. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

Author

McLelland, Gian-Luca, primary, Goiran, Thomas, additional, Yi, Wei, additional, Dorval, Geneviève, additional, Chen, Carol X, additional, Lauinger, Nadine D, additional, Krahn, Andrea I, additional, Valimehr, Sepideh, additional, Rakovic, Aleksandar, additional, Rouiller, Isabelle, additional, Durcan, Thomas M, additional, Trempe, Jean-François, additional, and Fon, Edward A, additional

Published
2018
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8. Author response: Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

Author

McLelland, Gian-Luca, primary, Goiran, Thomas, additional, Yi, Wei, additional, Dorval, Geneviève, additional, Chen, Carol X, additional, Lauinger, Nadine D, additional, Krahn, Andrea I, additional, Valimehr, Sepideh, additional, Rakovic, Aleksandar, additional, Rouiller, Isabelle, additional, Durcan, Thomas M, additional, Trempe, Jean-François, additional, and Fon, Edward A, additional

Published
2018
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15. USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.

Author

Durcan, Thomas M, Tang, Matthew Y, Pérusse, Joëlle R, Dashti, Eman A, Aguileta, Miguel A, McLelland, Gian‐Luca, Gros, Priti, Shaler, Thomas A, Faubert, Denis, Coulombe, Benoit, and Fon, Edward A

Subjects
GENETIC mutation, UBIQUITIN ligases, PARKINSON'S disease, MITOCHONDRIA, AUTOPHAGY, PROTEINS
Abstract

Mutations in the Park2 gene, encoding the E3 ubiquitin-ligase parkin, are responsible for a familial form of Parkinson's disease ( PD). Parkin-mediated ubiquitination is critical for the efficient elimination of depolarized dysfunctional mitochondria by autophagy (mitophagy). As damaged mitochondria are a major source of toxic reactive oxygen species within the cell, this pathway is believed to be highly relevant to the pathogenesis of PD. Little is known about how parkin-mediated ubiquitination is regulated during mitophagy or about the nature of the ubiquitin conjugates involved. We report here that USP8/ UBPY, a deubiquitinating enzyme not previously implicated in mitochondrial quality control, is critical for parkin-mediated mitophagy. USP8 preferentially removes non-canonical K6-linked ubiquitin chains from parkin, a process required for the efficient recruitment of parkin to depolarized mitochondria and for their subsequent elimination by mitophagy. This work uncovers a novel role for USP8-mediated deubiquitination of K6-linked ubiquitin conjugates from parkin in mitochondrial quality control. [ABSTRACT FROM AUTHOR]

Published
2014
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