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3. Data-driven multivariate cohort selection and automated CT scan lung volume measurement identifies disease progression in Idiopathic Pulmonary Fibrosis (IPF)

Author

Manners, H, primary, Mclellan, T, additional, Kirov, K, additional, Roberts, M, additional, Kanavati, F, additional, Mckenzie, G, additional, Gallagher, D, additional, Hainsworth, J, additional, Dosanjh, D, additional, Molyneaux, P, additional, Ruggiero, A, additional, and Thillai, M, additional

Published
2022
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12. The QRISK-2 Score Identifies an Increased Cardiovascular Risk in Patients with Idiopathic Pulmonary Fibrosis at Time of Diagnosis

Author

Thillai, M., primary, Herlekar, R., additional, Denneny, E.K., additional, Aggarwal, A., additional, Tailor, B., additional, Millward, K., additional, Stoneman, V., additional, Barker, H., additional, Fiddler, C., additional, Parfrey, H., additional, SImler, N., additional, Brereton, C., additional, Jones, M.G., additional, Fletcher, S., additional, Crawshaw, A., additional, Chaudhuri, N., additional, George, P.M., additional, Murphy, A., additional, Pontoppidan, K., additional, Ravenhill, G., additional, Wilson, A., additional, wickremasinghe, M., additional, and McLellan, T., additional

Published
2020
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16. One thousand plant transcriptomes and the phylogenomics of green plants

Author

Leebens, Mack J.H., Graham, S.W, Wong, G.K-S., DeGironimo, L., Edger, P.P., Jordon-Thaden, I.E., Joya, S., Melkonian, B., Miles, N.W., Pokorny Montero, L., Quigley, C., Thomas, P., Villarreal, J.C., Augustin, M.M., Barrett, M.D., Baucom, R.S., Beerling, D.J., Benstein, R.M., Biffin, E., Brockington, S.F., Burge, D.O., Burris, J.N., Burris, K.P., Burtet-Sarramegna, V., Caicedo, A.L., Cannon, S.B., Çebi, Z., Chang, Y., Chater, C., Cheeseman, J.M., Chen, T., Clarke, N.D., Clayton, H., Covshoff, S., Crandall-Stotler, B.J., Cross, H., Determann, R., Dickson, R.C., Di Stilio, V.S., Ellis, S., Fast, E., Feja, N., Field, K.J., Filatov, D.A., Finnegan, P.M., Floyd, S.K., Fogliani, B., GarcÍa, N., Gâteblé, G., Godden, G.T., Goh, Q., Greiner, S., Harkess, A., Heaney, Mike J., Helliwell, K.E., Heyduk, K., Hibberd, J.M., Hodel, R.G.J., Hollingsworth, P.M., Johnson, M.T.J., Jost, R., Joyce, B., Kapralov, M.V., Kazamia, E., Kellogg, E.A., Koch, M.A., Von Konrat, M., Könyves, K., Kutchan, T.M., Lam, V., Larsson, A., Leitch, A.R., Lentz, R., Li, F.-W., Lowe, A.J., Ludwig, M., Manos, P.S., Mavrodiev, E., McCormick, M.K., McKain, M, McLellan, T., McNeal, J., Miller, R., Nelson, M.N., Peng, Y., Ralph, P., Real, D., Riggins, C.W., Ruhsam, M., Sage, R.F., Sakai, A.K., Scascitella, M., Schilling, E.E., Schlösser, E., Sederoff, H., Servick, S., Shaw, A.J., Shaw, S.W., Sigel, E.M., Skema, C., Smith, A.G., Smithson, A., NeilStewart, C., Stinchcombe, J.R., Szövényi, P., Tate, J.A., Tiebel, H., Trapnell, D., Villegente, M., Wang, C., Weller, S.G., Wenzel, M., Weststrand, S., Westwood, J.H., Whigham, D.F., Wulff, A.S., Yang, Y., Zhu, D., Zhuang, C., Zuidof, J., Chase, M.W., Deyholos, M.K., Graham, S.W., Pires, J. Chris, Rothfels, C.J., Chen, C., Chen, L., Cheng, S., Li, J., Li, R., Li, X., Lu, H., Ou, Y., Tan, X., Tang, J., Tian, Z., Wang, F., Wang, J., Wei, X., Wong, G. K.-S., Xu, X., Yan, Z., Yang, F., Zhong, X., Zhou, F., Zhu, Y., Zhang, Y., Yu, J., Barkman, T. J., Carpenter, E. J., Liu, T., Sun, X., Wu, S., Mirarab, S., Nguyen, N., Gitzendanner, M. A., Ayyampalayam, S., Der, J., Matasci, N., Sayyari, E., Soltis, D. E., Soltis, P. S., Stevenson, D. W., Wafula, E. K., Walls, R., Wickett, N. J., De Pamphilis, C. W., Graham, S. W, Leebens-Mack, J. H., Warnow, T., Li, Z., An, H., Arrigo, N., Baniaga, A. E., Galuska, S., Jorgensen, S. A., Kidder, T. I., Kong, H., Lu-Irving, P., Marx, H. E., Qi, X., Reardon, C. R., Sessa, E. B., Sutherland, B. L., Tiley, G. P., Welles, S. R., Yu, R., Zhan, S., Barker, M. S., Porsch, M., Ullrich, K. K., Gramzow, L., Melkonian, M., Nelson, D. R., Theißen, G., Wong, G. K. S., Grosse, I., Rensing, S. A., Quint, M., Institut de sciences exactes et appliquées (ISEA), Université de la Nouvelle-Calédonie (UNC), Apollo - University of Cambridge Repository, National Key Research and Development Program (China), Ministry of Science and Technology of the People's Republic of China, Filatov, D, One Thousand Plant Transcriptomes Initiative, and School of Plant and Environmental Sciences

Subjects
0106 biological sciences, Genome evolution, Nuclear gene, 631/208/212/2306, [SDV]Life Sciences [q-bio], Viridiplantae, 01 natural sciences, Genome, Article, Evolution, Molecular, 03 medical and health sciences, Plant evolution, Phylogenomics, Databases, Genetic, Glaucophyta, 631/449/2669, 631/181/735, Plastid, Phylogeny, 45/90, 030304 developmental biology, 45/91, Adaptive radiation, 0303 health sciences, 631/181/759/2467, Multidisciplinary, biology, Archaeplastida, fungi, Botany, food and beverages, Botanik, 15. Life on land, biology.organism_classification, Biological Evolution, Evolutionary biology, Molecular evolution, Transcriptome, Genome, Plant, 010606 plant biology & botany
Abstract

Green plants (Viridiplantae) include around 450,000–500,000 species1,2 of great diversity and have important roles in terrestrial and aquatic ecosystems. Here, as part of the One Thousand Plant Transcriptomes Initiative, we sequenced the vegetative transcriptomes of 1,124 species that span the diversity of plants in a broad sense (Archaeplastida), including green plants (Viridiplantae), glaucophytes (Glaucophyta) and red algae (Rhodophyta). Our analysis provides a robust phylogenomic framework for examining the evolution of green plants. Most inferred species relationships are well supported across multiple species tree and supermatrix analyses, but discordance among plastid and nuclear gene trees at a few important nodes highlights the complexity of plant genome evolution, including polyploidy, periods of rapid speciation, and extinction. Incomplete sorting of ancestral variation, polyploidization and massive expansions of gene families punctuate the evolutionary history of green plants. Notably, we find that large expansions of gene families preceded the origins of green plants, land plants and vascular plants, whereas whole-genome duplications are inferred to have occurred repeatedly throughout the evolution of flowering plants and ferns. The increasing availability of high-quality plant genome sequences and advances in functional genomics are enabling research on genome evolution across the green tree of life., The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.

Published
2019
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34. Gastrointestinal barrier dysfunction, endotoxin neutralizing capacity and immuno-inflammatory mediators following repeated exertional heat stress exposure

Author

Selkirk, G. A., Wright, H. E., Rhind, S. G., and McLellan, T. M.

Abstract

Recent evidence in humans has shown a greater endotoxin leakage in sedentary untrained (UT) compared with endurance trained (TR) males at core temperatures below those normally assumed to be essential for the progression of heat illness or heat stroke during acute exertional heat stress (EHS) exposure [1]. Minimal data exists examining the role of gastrointestinal (GI) barrier function, circulating immuno-inflammatory mediators and physiological heat tolerance that accompanies repeated EHS exposures and whether the same cytoprotective responses observed in TR individuals [2] may be induced during repeated EHS in UT. The purpose of this work was to examine the immuno-inflammatory cascades accompanying classical physiological adaptations in untrained males following repeated EHS exposures. Nine UT males (Age = 27 ± 2 years, VO₂peak= 52 ± 2 mL·kgLBM⁻¹·min⁻¹, 17 ± 2% body fatness) walked to exhaustion (EXH) at 4.5 km·h⁻¹ with 2% elevation in a climatic chamber (40°C, 30% R.H.) while wearing encapsulating protective clothing on 9 separate days. Venous whole blood samples were collected at baseline (PRE), 38.0C, 38.5C, 39.0C and EXH on Days 1 and 9, while PRE/EXH samples were drawn on Days 5 and 6. Samples were analyzed for endogenous endotoxin, endotoxin neutralizing capacity (ENC) and for circulating immuno-inflammatory mediators macrophage inflammatory protein (MIP)-1β, IL-6, IL-10, lipopolysaccharide binding protein (LBP), soluble (s) CD14 and extracellular (e) HSP72 by ELISA. In addition, intracellular (i) HSP72 was examined in circulating leukocyte subsets by flow cytometry. Classical physiological adaptations, including reduced HR and increased tolerance time, delta core temperature tolerated, plasma volume and sweat rates were observed during repeated EHS exposure. Mild endotoxemia (21.3 ± 5 pg/mL) was observed at EXH on Days 1, 5, 6, 9 as well as a 14% reduction in ENC (12014 ± 717 vs. 10292 ± 929 ENU/mL) from PRE to EXH on Day 1. Accompanying the changes in endogenous endotoxin and thermoregulatory adaptations were enhanced circulating levels of IL-6, IL-10, LBP, sCD14 as well as cytoprotective increases in both eHSP72 and iHSP72. These findings suggest that GI barrier dysfunction may be an important mechanism of immuno-inflammatory modulation and cytoprotective adaptations observed following repeated EHS exposures., Exercise and Immunity in Athletic Performance and a Healthy Life, 10th ISEI Symposium (International Society of Exercise and Immunology), July 11-13, 2011, Oxford, UK

Published
2011

39. Don't Dwell on it: The impact of rumination on emotional sensitivity

Author

Johnston, L., Carter, J., Mclellan, T., Johnston, L., Carter, J., and Mclellan, T.

Abstract

The relationship between level of depressive symptoms, ruminative response style and sensitivity to facial expressions of emotion was investigated among female university students. Participants were able to distinguish between facial expressions (of happiness and sadness) that were and were not associated with experience of a corresponding affective state. For sadness, there was a negative relationship between rumination and emotion sensitivity, and a positive relationship between rumination and bias. Results are discussed in terms of the influence of individual differences on sensitivity to the emotional state of interaction partners.

Published
2011

40. Caffeinated Gum Maintains Vigilance, Marksmanship, and PVT Performance During a 55 Hour Field Trial

Author

WALTER REED ARMY INST OF RESEARCH WASHINGTON DC, Kamimori, G. H., Johnson, D., Belenky, G., McLellan, T., Bell, D., WALTER REED ARMY INST OF RESEARCH WASHINGTON DC, Kamimori, G. H., Johnson, D., Belenky, G., McLellan, T., and Bell, D.

Abstract

In a 2001 report the Committee on Military Nutrition Research (CMNR) stated that military personnel are often placed in unique situations in which extended alertness is required. This is most evident in situations involving sentry duty, radar monitoring, communications, long-range air support missions, and logistical supply requirements as well as in combat itself. In addition, personnel are often required to forgo sleep in order to meet mission requirements and this inevitably leads to various degrees of sleep deprivation. It is well accepted that restricted and/or total sleep deprivation will result in a concomitant impairment in cognitive performance (for reviews see Angus et al., 1992; Dinges and Kribbs, 1991). Caffeine's ability to maintain or improve mental performance in rested, fatigued, and/or sleep deprived individuals has been well documented (for reviews see Fredholm et al., 1999; Lieberman et al., 2001; and Smith, 2002) and the CMNR (2001) has recommended caffeine for use as a fatigue countermeasure. Two important areas of concern with caffeine are how it can be delivered and the duration of its effects. Kamimori et al. (2002) have demonstrated that caffeine, administered in a chewing gum formulation, can be delivered three times faster in comparison to a capsule formulation., See also ADM001736, Proceedings for the Army Science Conference (24th) Held on 29 November - 2 December 2004 in Orlando, Florida.

Published
2004

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