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Your search keyword '"McLaughlin, Emily C."' showing total 24 results
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24 results on '"McLaughlin, Emily C."'

1. Canadian 24-Hour Movement Guidelines for Adults aged 18–64 years and Adults aged 65 years or older: an integration of physical activity, sedentary behaviour, and sleep

Author

Ross, Robert, primary, Chaput, Jean-Philippe, additional, Giangregorio, Lora M., additional, Janssen, Ian, additional, Saunders, Travis J., additional, Kho, Michelle E., additional, Poitras, Veronica J., additional, Tomasone, Jennifer R., additional, El-Kotob, Rasha, additional, McLaughlin, Emily C., additional, Duggan, Mary, additional, Carrier, Julie, additional, Carson, Valerie, additional, Chastin, Sebastien F., additional, Latimer-Cheung, Amy E., additional, Chulak-Bozzer, Tala, additional, Faulkner, Guy, additional, Flood, Stephanie M., additional, Gazendam, Mary Kate, additional, Healy, Genevieve N., additional, Katzmarzyk, Peter T., additional, Kennedy, William, additional, Lane, Kirstin N., additional, Lorbergs, Amanda, additional, Maclaren, Kaleigh, additional, Marr, Sharon, additional, Powell, Kenneth E., additional, Rhodes, Ryan E., additional, Ross-White, Amanda, additional, Welsh, Frank, additional, Willumsen, Juana, additional, and Tremblay, Mark S., additional

Published
2020
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17. Allylic oxidations catalyzed by dirhodium caprolactamate via aqueous tert-butyl hydroperoxide: the role of the tert-butylperoxy radical

Author

McLaughlin, Emily C., Hojae Choi, Kan Wang, Chiou, Grace, and Doyle, Michael P.

Subjects
Catalysis -- Analysis, Oxidation-reduction reaction -- Analysis, Rhodium -- Chemical properties, Tertiary butyl compounds -- Chemical properties
Abstract

The application of dirhodium(II) caprolactamate as an efficient engine for the production of the tert-butylperoxy radical and selective reagent for hydrogen atom abstraction is demonstrated. The mechanistic implications arising from studies of allylic oxidation with enones provide new insights into factors that control product formation.

Published
2009

18. Propargylic oxidations catalyzed by dirhodium caprolactamate in water: efficient access to [alpha],[beta]-acetylenic ketones

Author

McLaughlin, Emily C. and Doyle, Michael P.

Subjects
Ketones -- Chemical properties, Organometallic compounds -- Chemical properties, Oxidation-reduction reaction -- Analysis, Rhodium -- Chemical properties
Abstract

The selective C-H oxidation of alkynes to propargylic ketones was performed by using dirhohdium caprolactamate ([Rh.sub.2][(cap).sub.4]) with 70 percent w/w aqueous tert-butyl hydroperoxide as a highly effective catalytic oxidation protocol. The oxidation in aqueous solvent under mild condition with yields about 80 percent of [alpha],[beta]-acetylenic carbonyl compounds was found.

Published
2008

19. Structural insights into the interactions of xpt riboswitch with novel guanine analogues: a molecular dynamics simulation study

Author

Jain, Swapan S., Uddhavesh B. Sonavane, Mallikarjunachari V.N. Uppuladinne, McLaughlin, Emily C., Weiqing Wang, Sheneil Black, and Joshi, Rajendra R.

Abstract

Ligand recognition in purine riboswitches is a complex process requiring different levels of conformational changes. Recent efforts in the area of purine riboswitch research have focused on ligand analogue binding studies. In the case of the guanine xanthine phosphoribosyl transferase (xpt) riboswitch, synthetic analogues that resemble guanine have the potential to tightly bind and subsequently influence the genetic expression of xpt mRNA in prokaryotes. We have carried out 25 ns Molecular Dynamics (MD) simulation studies of the aptamer domain of the xpt G-riboswitch in four different states: guanine riboswitch in free form, riboswitch bound with its cognate ligand guanine, and with two guanine analogues SJ1 and SJ2. Our work reveals novel interactions of SJ1 and SJ2 ligands with the binding core residues of the riboswitch. The ligands proposed in this work bind to the riboswitch with greater overall stability and lower root mean square deviations and fluctuations compared to guanine ligand. Reporter gene assay data demonstrate that the ligand analogues, upon binding to the RNA, lower the genetic expression of the guanine riboswitch. Our work has important implications for future ligand design and binding studies in the exciting field of riboswitches.

Published
2014
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20. Guidance for Entering Academics in Organic Chemistry.

Author

McLaughlin, Emily C., College, Bard, Forbes, David C., and Doyle, Michael P.

Subjects
COLLEGE teachers, ORGANIC chemistry education in universities & colleges, CHEMISTRY students, JOB performance, PROFESSIONAL ethics, CURRICULUM
Abstract

The article presents guidelines for college teachers to teach organic chemistry in the U.S. These guidelines include inquiring about the internal support available for teachers at an institution, regular performance assessments of full-time, tenure-track teachers, and writing a proposal for research support. It provides information on the traditional curriculums for chemistry courses, student recruitment and mentoring, and professional ethics.

Published
2013

21. Structural insights into the interactions of xptriboswitch with novel guanine analogues: a molecular dynamics simulation study

Author

Jain, Swapan S., Sonavane, Uddhavesh B., Uppuladinne, Mallikarjunachari V.N., McLaughlin, Emily C., Wang, Weiqing, Black, Sheneil, and Joshi, Rajendra R.

Abstract

Ligand recognition in purine riboswitches is a complex process requiring different levels of conformational changes. Recent efforts in the area of purine riboswitch research have focused on ligand analogue binding studies. In the case of the guanine xanthine phosphoribosyl transferase (xpt) riboswitch, synthetic analogues that resemble guanine have the potential to tightly bind and subsequently influence the genetic expression of xptmRNA in prokaryotes. We have carried out 25 ns Molecular Dynamics (MD) simulation studies of the aptamer domain of the xptG-riboswitch in four different states: guanine riboswitch in free form, riboswitch bound with its cognate ligand guanine, and with two guanine analogues SJ1 and SJ2. Our work reveals novel interactions of SJ1 and SJ2 ligands with the binding core residues of the riboswitch. The ligands proposed in this work bind to the riboswitch with greater overall stability and lower root mean square deviations and fluctuations compared to guanine ligand. Reporter gene assay data demonstrate that the ligand analogues, upon binding to the RNA, lower the genetic expression of the guanine riboswitch. Our work has important implications for future ligand design and binding studies in the exciting field of riboswitches.

Published
2015
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22. Structural insights into the interactions of xpt riboswitch with novel guanine analogues: a molecular dynamics simulation study.

Author

Jain SS, Sonavane UB, Uppuladinne MV, McLaughlin EC, Wang W, Black S, and Joshi RR

Subjects
Aptamers, Nucleotide chemistry, Base Sequence, Gene Expression Regulation, Bacterial, Genes, Reporter, Guanine physiology, Hydrogen Bonding, Inverted Repeat Sequences, Molecular Dynamics Simulation, Nucleic Acid Conformation, Pentosyltransferases genetics, Thermodynamics, Transcriptional Activation, beta-Galactosidase biosynthesis, beta-Galactosidase genetics, Guanine analogs & derivatives, Guanine chemistry, Pentosyltransferases chemistry, Riboswitch
Abstract

Ligand recognition in purine riboswitches is a complex process requiring different levels of conformational changes. Recent efforts in the area of purine riboswitch research have focused on ligand analogue binding studies. In the case of the guanine xanthine phosphoribosyl transferase (xpt) riboswitch, synthetic analogues that resemble guanine have the potential to tightly bind and subsequently influence the genetic expression of xpt mRNA in prokaryotes. We have carried out 25 ns Molecular Dynamics (MD) simulation studies of the aptamer domain of the xpt G-riboswitch in four different states: guanine riboswitch in free form, riboswitch bound with its cognate ligand guanine, and with two guanine analogues SJ1 and SJ2. Our work reveals novel interactions of SJ1 and SJ2 ligands with the binding core residues of the riboswitch. The ligands proposed in this work bind to the riboswitch with greater overall stability and lower root mean square deviations and fluctuations compared to guanine ligand. Reporter gene assay data demonstrate that the ligand analogues, upon binding to the RNA, lower the genetic expression of the guanine riboswitch. Our work has important implications for future ligand design and binding studies in the exciting field of riboswitches.

Published
2015
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23. Intramolecular photocycloaddition of dioxenones with alkynes: formation of secondary photoproducts from cyclobutene photoadducts.

Author

Winkler JD and McLaughlin EC

Subjects
Cyclization, Molecular Structure, Photochemistry, Alkenes chemistry, Alkynes chemistry, Cyclobutanes chemistry, Dioxanes chemistry, Heterocyclic Compounds, 3-Ring chemistry
Abstract

[Reaction: see text] Intramolecular photocycloaddition of 4 leads to the formation of cyclobutene photoadduct 5. Secondary photoreaction of 5 then affords either cyclobutane 19 or the bridged product 7, as a function of R (H or TMS).

Published
2005
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24. Tandem Diels-Alder/fragmentation approach to the synthesis of eleutherobin.

Author

Winkler JD, Quinn KJ, MacKinnon CH, Hiscock SD, and McLaughlin EC

Subjects
Anthozoa chemistry, Cyclization, Indicators and Reagents, Molecular Conformation, Alkaloids chemical synthesis, Antineoplastic Agents chemical synthesis, Diterpenes
Abstract

[reaction: see text] A synthesis of 28, the carbon framework of the eleutherobin aglycone, is reported in a 15-step sequence from readily available starting materials. The tandem Diels-Alder reaction of 6 and 7 to produce 18, in which three new rings and six new stereocenters are formed, is a key step in the reaction sequence.

Published
2003
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