217 results on '"McKew, John C."'
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2. Evaluation of chronic toxicity of cyclocreatine, a creatine analog, in Sprague Dawley rat after oral gavage administration for up to 26 weeks
3. OR21-03 Dose Responsiveness Of LUM-201 As Measured By Acute GH Response And IGF-1 And Annualized Height Velocity (AHV) Measured At 6 Months In The Interim Analysis Of The OraGrowtH212 Study In Idiopathic Pediatric Growth Hormone Deficiency (iPGHD)
4. OR21-06 Growth Response Of Oral LUM-201 In OraGrowtH210 And OraGrowtH212 Trials In Idiopathic Pediatric Growth Hormone Deficiency (iPGHD): Combined Analysis Interim Analysis Data
5. A high-throughput screening assay for determining cellular levels of total tau protein.
6. Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency
7. Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1–2 trial
8. Quantitative hydrophilic interaction chromatography–mass spectrometry analysis of N-acetylneuraminic acid and N-acetylmannosamine in human plasma
9. High-Throughput Viability Assay Using an Autonomously Bioluminescent Cell Line with a Bacterial Lux Reporter
10. ERK and β-Arrestin Interaction: A Converging Point of Signaling Pathways for Multiple Types of Cell Surface Receptors
11. Ligand-Free Signaling of G-Protein-Coupled Receptors: Relevance to μ Opioid Receptors in Analgesia and Addiction
12. Niemann–Pick Disease Type C: Induced Pluripotent Stem Cell–Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy
13. A Phenotypic Compound Screening Assay for Lysosomal Storage Diseases
14. Phenotypic screens as a renewed approach for drug discovery
15. An Alternative Direct Compound Dispensing Method Using the HP D300 Digital Dispenser
16. Evaluation of Cholesterol Reduction Activity of Methyl-β-cyclodextrin Using Differentiated Human Neurons and Astrocytes
17. New Financial and Research Models for Pediatric Orphan Drug Development: Focus on the NCATS TRND Program
18. Evaluation of chronic toxicity of cyclocreatine in beagle dogs after oral gavage administration for up to 23 weeks
19. Benzhydrylquinazolinediones: Novel cytosolic phospholipase A 2α inhibitors with improved physicochemical properties
20. A high-throughput screening assay for assessing the viability of Cryptococcus neoformans under nutrient starvation conditions
21. Benzenesulfonamide indole inhibitors of cytosolic phospholipase A 2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy
22. Blockade of cytosolic phospholipase A 2α prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses
23. Mutation Update for GNE Gene Variants Associated with GNE Myopathy
24. Development of a Predictive Enrichment Marker for the Oral GH Secretagogue LUM-201 in Pediatric Growth Hormone Deficiency
25. Corroboration of Height Velocity Prediction Markers for rhGH With an Oral GH Secretagogue Treatment in Children With GHD
26. Doubly diastereoselective indolactonizations: olefin and face selectivity in nona-2,7-diene-5-carboxylic acid cyclizations
27. Iterative enolate Claisen rearrangements: versatile route to optically pure 2,7-nonadiene-5-carboxylic acids
28. In vitro evaluation of imidazo[4,5-c]quinolin-2-ones as gametocytocidal antimalarial agents
29. Efficient Synthesis of 1,9-Substituted Benzo[h][1,6]naphthyridin-2(1H)-ones and Evaluation of their Plasmodium falciparum Gametocytocidal Activities
30. Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents
31. Synthesis of pyrazolo[1,5-[alpha]]pyrimidinone regioisomers
32. Safety, pharmacokinetics and sialic acid production after oral administration of N -acetylmannosamine (ManNAc) to subjects with GNE myopathy
33. Playing Well with Others! Initiating and sustaining successful collaborations between Industry, Academia and Government
34. Collaborative Development of 2-Hydroxypropyl-β-Cyclodextrin for the Treatment of Niemann-Pick Type C1 Disease
35. High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1
36. In vitro evaluation of imidazo[4,5 -c ]quinolin-2-ones as gametocytocidal antimalarial agents
37. High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress
38. Phase 1/2 evaluation of intrathecal 2-hydroxypropyl-β-cyclodextrin for the treatment of Niemann-Pick disease type C1
39. Efficient Synthesis of 1,9-Substituted Benzo[h][1,6]naphthyridin-2(1H)-ones and Evaluation of their Plasmodium falciparum Gametocytocidal Activities.
40. Financing translation: Analysis of the NCATS rare-diseases portfolio
41. Atypical presentation of GNE myopathy with asymmetric hand weakness
42. Mutation Update forGNEGene Variants Associated with GNE Myopathy
43. Delta-tocopherol facilitates generation of induced pluripotent stem cells from fibroblasts with Niemann-Pick disease type C
44. Chemical signatures and new drug targets for gametocytocidal drug development
45. Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs
46. Correction: Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens
47. Rapid Identification of Antifungal Compounds against Exserohilum rostratum Using High Throughput Drug Repurposing Screens
48. A quantitative high throughput assay for identifying gametocytocidal compounds
49. NIH TRND program: successes in preclinical therapeutic development
50. δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders.
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