Search

Your search keyword '"McKeown, Alex"' showing total 151 results
Start Over Author "McKeown, Alex"
151 results on '"McKeown, Alex"'

2. Education for Collaboration: The Influence of the Third Space on Professional Boundaries

Author

Knight, Laura, Crampton, Paul, McKeown, Alex, Arora, Arun, Cliffe, Charlotte, O'Keeffe, Catherine, and Griffin, Ann

Abstract

The delivery of integrated care requires the establishment of effective professional relationships that foster collaborative working across health systems. Evidence for how to prepare practitioners to work in those settings is limited. By exploring an innovative postgraduate Programme for Integrated Child Health (PICH) this article highlights the conditions by which effective collaboration can be encouraged. Our qualitative evaluation of PICH involved one-to-one semi-structured interviews with 23 postgraduate general practice and paediatric trainees and their mentors. We analysed the data using the concept of the 'third space', where multiple discourses between individuals with diverse professional backgrounds occur, enabling creative exploration of tensions inherent in new ways of working in order to identify enablers and barriers to collaboration. Our analysis identified three themes that enabled collaboration: effective communication, boundary work and educational spaces; and four themes that were barriers: traditional hierarchical professional identities, curriculum design, financial systems and workplace spaces. PICH demonstrated the value of educational spaces and their role in enabling collaborative practice, as participants explored their professional identities and those of other disciplines. Structural factors in the workplace which inhibit collaborative practice were also evident. We conclude by proposing a model for collaborative learning in third spaces based upon the recognition that, while educational programmes alone will not lead to change, they have the potential to inform the development of productive workplace spaces that will be required if collaborative practice in healthcare is to become a reality.

Published
2022

3. Chapter Is coercion ever beneficent?

Author

McKeown, Alex, Mortimer, Rose, Manzini, Arianna, and Singh, Ilina

Subjects
mental health, public health, ethics, bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPK Mental health services
Abstract

Early intervention in mental health seeks to improve the wellbeing of as many people as possible, by intervening at an early stage in the onset of illness, or by taking preventative action in ‘at risk’ populations. The paradigm is rhetorically powerful, and it is easy to talk in terms of it helping to deliver rights to health and realise social justice. However, in spite – or perhaps because – of the apparently unarguable desirability of such goals, it is harder to discuss rights to dissent. In this respect the risk of coercion is an issue that should be discussed, especially because of the stigmatizing effect that the labelling associated with early intervention may have in mental health contexts. Here we explore this issue, with a particular focus on its practical and ethical implications in relation to UK policy for treating Attention Deficit Hyperactivity Disorder and mild Conduct Disorder in young people.

Published
2019

5. Pegcetacoplan Treatment and Consensus Features of Geographic Atrophy Over 24 Months

Author

Fu, Dun Jack, primary, Bagga, Pallavi, additional, Naik, Gunjan, additional, Glinton, Sophie, additional, Faes, Livia, additional, Liefers, Bart, additional, Lima, Rosana, additional, Wignall, Georgina, additional, Keane, Pearse A., additional, Ioannidou, Estelle, additional, Ribeiro Reis, Ana Paula, additional, McKeown, Alex, additional, Scheibler, Lukas, additional, Patel, Praveen J., additional, Moghul, Ismail, additional, Pontikos, Nikolas, additional, and Balaskas, Konstantinos, additional

Published
2024
Full Text
View/download PDF

8. Deep-learning automated quantification of longitudinal OCT scans demonstrates reduced RPE loss rate, preservation of intact macular area and predictive value of isolated photoreceptor degeneration in geographic atrophy patients receiving C3 inhibition treatment

Author

Dun Jack Fu, Glinton, Sophie, Lipkova, Veronika, Faes, Livia, Liefers, Bart, Gongyu Zhang, Pontikos, Nikolas, McKeown, Alex, Scheibler, Lukas, Patel, Praveen J., Keane, Pearse A., and Balaskas, Konstantinos

Abstract

Objective To evaluate the role of automated optical coherence tomography (OCT) segmentation, using a validated deep-learning model, for assessing the effect of C3 inhibition on the area of geographic atrophy (GA); the constituent features of GA on OCT (photoreceptor degeneration (PRD), retinal pigment epithelium (RPE) loss and hypertransmission); and the area of unaffected healthy macula. To identify OCT predictive biomarkers for GA growth. Methods Post hoc analysis of the FILLY trial using a deep-learning model for spectral domain OCT (SD-OCT) autosegmentation. 246 patients were randomised 1:1:1 into pegcetacoplan monthly (PM), pegcetacoplan every other month (PEOM) and sham treatment (pooled) for 12 months of treatment and 6 months of therapy-free monitoring. Only participants with Heidelberg SD-OCT were included (n=197, single eye per participant). The primary efficacy endpoint was the square root transformed change in area of GA as complete RPE and outer retinal atrophy (cRORA) in each treatment arm at 12 months, with secondary endpoints including RPE loss, hypertransmission, PRD and intact macular area. Results Eyes treated PM showed significantly slower mean change of cRORA progression at 12 and 18 months (0.151 and 0.277 mm, p=0.0039; 0.251 and 0.396 mm, p=0.039, respectively) and RPE loss (0.147 and 0.287 mm, p=0.0008; 0.242 and 0.410 mm, p=0.00809). PEOM showed significantly slower mean change of RPE loss compared with sham at 12 months (p=0.0313). Intact macular areas were preserved in PM compared with sham at 12 and 18 months (p=0.0095 and p=0.044). PRD in isolation and intact macula areas was predictive of reduced cRORA growth at 12 months (coefficient 0.0195, p=0.01 and 0.00752, p=0.02, respectively). Conclusion The OCT evidence suggests that pegcetacoplan slows progression of cRORA overall and RPE loss specifically while protecting the remaining photoreceptors and slowing the progression of healthy retina to iRORA. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

9. Ethical, legal and social aspects of human cerebral organoids and their governance in Germany, the United Kingdom and the United States

Author

Pichl, Anja, primary, Ranisch, Robert, additional, Altinok, Ozan Altan, additional, Antonakaki, Melpomeni, additional, Barnhart, Andrew J., additional, Bassil, Katherine, additional, Boyd, J. Lomax, additional, Chinaia, Alice Andrea, additional, Diner, Sarah, additional, Gaillard, Maxence, additional, Greely, Henry T., additional, Jowitt, Joshua, additional, Kreitmair, Karola, additional, Lawrence, David, additional, Lee, Tim Nicholas, additional, McKeown, Alex, additional, Sachdev, Vorathep, additional, Schicktanz, Silke, additional, Sugarman, Jeremy, additional, Trettenbach, Katharina, additional, Wiese, Lara, additional, Wolff, Hannes, additional, and Árnason, Garðar, additional

Published
2023
Full Text
View/download PDF

10. What outcomes are important to patients with mild cognitive impairment or Alzheimer's disease, their caregivers, and health-care professionals? A systematic review

Author

Tochel, Claire, Smith, Michael, Baldwin, Helen, Gustavsson, Anders, Ly, Amanda, Bexelius, Christin, Nelson, Mia, Bintener, Christophe, Fantoni, Enrico, Garre-Olmo, Josep, Janssen, Olin, Jindra, Christoph, Jørgensen, Isabella F., McKeown, Alex, Öztürk, Buket, Ponjoan, Anna, Potashman, Michele H., Reed, Catherine, Roncancio-Diaz, Emilse, Vos, Stephanie, and Sudlow, Cathie

Published
2019
Full Text
View/download PDF

13. Deep-learning automated quantification of longitudinal OCT scans demonstrates reduced RPE loss rate, preservation of intact macular area and predictive value of isolated photoreceptor degeneration in geographic atrophy patients receiving C3 inhibition treatment

Author

Fu, Dun Jack, primary, Glinton, Sophie, additional, Lipkova, Veronika, additional, Faes, Livia, additional, Liefers, Bart, additional, Zhang, Gongyu, additional, Pontikos, Nikolas, additional, McKeown, Alex, additional, Scheibler, Lukas, additional, Patel, Praveen J, additional, Keane, Pearse A, additional, and Balaskas, Konstantinos, additional

Published
2023
Full Text
View/download PDF

14. Deep-learning automated quantification of longitudinal OCT scans demonstrates reduced RPE loss rate, preservation of intact macular area and predictive value of isolated photoreceptor degeneration in geographic atrophy patients receiving C3 inhibition treatment

Author

Fu, Dun Jack, Glinton, Sophie, Lipkova, Veronika, Faes, Livia, Liefers, Bart, Zhang, Gongyu, Pontikos, Nikolas, McKeown, Alex, Scheibler, Lukas, Patel, Praveen J, Keane, Pearse A, and Balaskas, Konstantinos

Abstract

ObjectiveTo evaluate the role of automated optical coherence tomography (OCT) segmentation, using a validated deep-learning model, for assessing the effect of C3 inhibition on the area of geographic atrophy (GA); the constituent features of GA on OCT (photoreceptor degeneration (PRD), retinal pigment epithelium (RPE) loss and hypertransmission); and the area of unaffected healthy macula.To identify OCT predictive biomarkers for GA growth.MethodsPost hoc analysis of the FILLY trial using a deep-learning model for spectral domain OCT (SD-OCT) autosegmentation. 246 patients were randomised 1:1:1 into pegcetacoplan monthly (PM), pegcetacoplan every other month (PEOM) and sham treatment (pooled) for 12 months of treatment and 6 months of therapy-free monitoring. Only participants with Heidelberg SD-OCT were included (n=197, single eye per participant).The primary efficacy endpoint was the square root transformed change in area of GA as complete RPE and outer retinal atrophy (cRORA) in each treatment arm at 12 months, with secondary endpoints including RPE loss, hypertransmission, PRD and intact macular area.ResultsEyes treated PM showed significantly slower mean change of cRORA progression at 12 and 18 months (0.151 and 0.277 mm, p=0.0039; 0.251 and 0.396 mm, p=0.039, respectively) and RPE loss (0.147 and 0.287 mm, p=0.0008; 0.242 and 0.410 mm, p=0.00809). PEOM showed significantly slower mean change of RPE loss compared with sham at 12 months (p=0.0313). Intact macular areas were preserved in PM compared with sham at 12 and 18 months (p=0.0095 and p=0.044). PRD in isolation and intact macula areas was predictive of reduced cRORA growth at 12 months (coefficient 0.0195, p=0.01 and 0.00752, p=0.02, respectively)ConclusionThe OCT evidence suggests that pegcetacoplan slows progression of cRORA overall and RPE loss specifically while protecting the remaining photoreceptors and slowing the progression of healthy retina to iRORA.

Published
2024
Full Text
View/download PDF

21. The Effect of Pegcetacoplan Treatment on Photoreceptor Maintenance in Geographic Atrophy Monitored by Artificial Intelligence–Based OCT Analysis

Author

Riedl, Sophie, primary, Vogl, Wolf-Dieter, additional, Mai, Julia, additional, Reiter, Gregor S., additional, Lachinov, Dmitrii, additional, Grechenig, Christoph, additional, McKeown, Alex, additional, Scheibler, Lukas, additional, Bogunović, Hrvoje, additional, and Schmidt-Erfurth, Ursula, additional

Published
2022
Full Text
View/download PDF

27. Machine-learning and Automatically Segmented Retinal Biomarkers Generate Spatial Heatmaps Predictive for Standard and Low Luminance Visual Acuity in Geographic Atrophy

Author

Balaskas, Konstantinos, primary, Glinton, Sophie, additional, Keenan, Tiarnan, additional, Faes, Livia, additional, Liefers, Bart, additional, Zhang, Gongyu, additional, Pontikos, Nikolas, additional, Struyven, Robbert, additional, Wagner, Siegfried, additional, McKeown, Alex, additional, Patel, Praveen, additional, Keane, Pearse, additional, and Fu, Dun Jack, additional

Published
2022
Full Text
View/download PDF

29. Ethics and professionalism in healthcare

Author

Berger, Sarah, primary, Famenka, Andrei, additional, Fragemann, Kristin, additional, Fürholzer, Katharina, additional, McKeown, Alex, additional, Rüsche, Stephanie, additional, Šendula-Pavelić, Martina, additional, Stănescu, Dorina Maria, additional, Stepurko, Tetiana, additional, Tangerding, Clemens, additional, and Yu, Christopher, additional

Published
2016
Full Text
View/download PDF

34. Veil

Author

McKeown, Alex

Published
2016

43. Revalidation and quality assurance: the application of the MUSIQ framework in independent verification visits to healthcare organisations

Author

Griffin, Ann, McKeown, Alex, Viney, Rowena, Rich, Antonia, Welland, Trevor, Gafson, Irene, and Woolf, Katherine

Abstract

Objectives We present a national evaluation of the impact of independent verification visits (IVVs) performed by National Health Service (NHS) England as part of quality assuring medical revalidation. Organisational visits are central to NHS quality assurance. They are costly, yet little empirical research evidence exists concerning their impact, and what does exist is conflicting.\ud \ud Setting The focus was on healthcare providers in the NHS (in secondary care) and private sector across England, who were designated bodies (DBs). DBs are healthcare organisations that have a statutory responsibility, via the lead clinician, the responsible officer (RO), to implement medical revalidation.\ud \ud Participants All ROs who had undergone an IVV in England in 2014 and 2015 were invited to participate. 46 ROs were interviewed. Ethnographic data were gathered at 18 observations of the IVVs and 20 IVV post visit reports underwent documentary analysis.\ud \ud Primary and secondary outcome measures Primary outcomes were the findings pertaining to the effectiveness of the IVV system in supporting the revalidation processes at the DBs. Secondary outcomes were methodological, relating to the Model for Understanding Success in Quality (MUSIQ) and how its application to the IVV reveals the relevance of contextual factors described in the model.\ud \ud Results The impact of the IVVs varied by DB according to three major themes: the personal context of the RO; the organisational context of the DB; and the visit and its impact. ROs were largely satisfied with visits which raised the status of appraisal within their organisations. Inadequate or untimely feedback was associated with dissatisfaction.\ud \ud Conclusions Influencing teams whose prime responsibility is establishing processes and evaluating progress was crucial for internal quality improvement. Visits acted as a nudge, generating internal quality review, which was reinforced by visit teams with relevant expertise. Diverse team membership, knowledge transfer and timely feedback made visits more impactful.

Published
2017

44. Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning

Author

Kermany, Daniel S., primary, Goldbaum, Michael, additional, Cai, Wenjia, additional, Valentim, Carolina C.S., additional, Liang, Huiying, additional, Baxter, Sally L., additional, McKeown, Alex, additional, Yang, Ge, additional, Wu, Xiaokang, additional, Yan, Fangbing, additional, Dong, Justin, additional, Prasadha, Made K., additional, Pei, Jacqueline, additional, Ting, Magdalene Y.L., additional, Zhu, Jie, additional, Li, Christina, additional, Hewett, Sierra, additional, Dong, Jason, additional, Ziyar, Ian, additional, Shi, Alexander, additional, Zhang, Runze, additional, Zheng, Lianghong, additional, Hou, Rui, additional, Shi, William, additional, Fu, Xin, additional, Duan, Yaou, additional, Huu, Viet A.N., additional, Wen, Cindy, additional, Zhang, Edward D., additional, Zhang, Charlotte L., additional, Li, Oulan, additional, Wang, Xiaobo, additional, Singer, Michael A., additional, Sun, Xiaodong, additional, Xu, Jie, additional, Tafreshi, Ali, additional, Lewis, M. Anthony, additional, Xia, Huimin, additional, and Zhang, Kang, additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results