34 results on '"McKeever, Brian M."'
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2. Crystal Structure of Inhibitor-Bound Human 5-Lipoxygenase: Activating Protein
3. Binding of a Reduced-Peptide Inhibitor and a Statine-Containing Inhibitor to the Protease from the Human Immunodeficiency Virus
4. Structural Studies of Elastase-Inhibitor Complexes with ß-Lactams
5. Protein Crystal Growth in Microgravity
6. Structure of Human Neutrophil Elastase in Complex with a Peptide Chloromethyl Ketone Inhibitor at 1.84- angstrom Resolution
7. A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia
8. Amino acid substitution of arginine 80 in 17β-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation/reduction kinetics
9. Human Immunodeficiency Virus (Type 1) Protease: Enzymology and Three-Dimensional Structure of a New AIDS Drug Target
10. Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core
11. Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist
12. Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket
13. Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1
14. Spirocyclic ureas: Orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design
15. Optimization of orally bioavailable alkyl amine renin inhibitors
16. Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1
17. New Renin Inhibitor VTP-27999 Alters Renin Immunoreactivity and Does Not Unfold Prorenin
18. Structure-Based Design of β-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease
19. Regulation of Sphingomyelin Phosphodiesterase Acid-Like 3A Gene (SMPDL3A) by Liver X Receptors
20. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility
21. Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1
22. Expression, purification and crystallization of human 5-lipoxygenase-activating protein with leukotriene-biosynthesis inhibitors
23. Design and Synthesis of α-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPARα/γ Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity
24. The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1
25. Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors
26. Structure-BasedDesign of β-Site APPCleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’sDisease.
27. Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl design
28. New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides
29. Protein crystal growth results for shuttle flights STS-26 and STS-29
30. Expression, purification and crystallization of human 5-lipoxygenase-activating protein with leukotriene-biosynthesis inhibitors.
31. A Role for the Aspartyl Protease from the Human Immunodeficiency Virus Type 1 (HIV‐1) in the Orchestration of Virus Assembly
32. A Role for the Aspartyl Protease from the Human Immunodeficiency Virus Type 1 (HIV-1) in the Orchestration of Virus Assembly.
33. 24 - Human Immunodeficiency Virus (Type 1) Protease: Enzymology and Three-Dimensional Structure of a New AIDS Drug Target
34. Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.
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